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https://www.readbyqxmd.com/read/29776950/clinical-effects-and-safety-of-electroacupuncture-for-the-treatment-of-post-stroke-depression-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#1
Xue-Bin Li, Jie Wang, An-Ding Xu, Jian-Min Huang, Lan-Qing Meng, Rui-Ya Huang, Jing Xu
OBJECTIVE: The aim of this systematic review was to assess the efficacy/effectiveness and safety of electroacupuncture (EA) in the treatment of post-stroke depression (PSD). METHODS: A comprehensive literature search in the Pubmed, Embase, CENTRAL, ISI Web of Science, CNKI and Wanfang databases was conducted, and all relevant randomised controlled trials (RCTs) were screened for eligibility by two independent reviewers. The Cochrane Collaboration's tool and Jadad score were used to assess the risk of bias of included studies, and only RCTs scoring ≥3 were included in a meta-analysis...
May 18, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29769065/prevalence-patterns-and-predictors-of-depression-treatment-among-community-dwelling-older-adults-with-stroke-in-the-united-states-a-cross-sectional-study
#2
Sandipan Bhattacharjee, Majed Al Yami, Sawsan Kurdi, David Rhys Axon
BACKGROUND: Depression is one of the most common psychiatric conditions among stroke survivors and is associated with several negative health outcomes. However, little is known about the depression treatment patterns among stroke survivors. The objective of this study was to examine national-level prevalence, patterns and predictors of depression treatment among community-dwelling stroke survivors. METHODS: This study adopted a retrospective, cross-sectional study design using multiple years of Medical Expenditure Panel Survey (MEPS) (2002-2012) data...
May 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29762694/comparative-study-of-postmortem-concentrations-of-antidepressants-in-several-different-matrices
#3
Åse Marit Leere Øiestad, Ritva Karinen, Sidsel Rogde, Stian Nilsen, Kari-Beate Boye Eldor, Gerd-Wenche Brochmann, Marianne Arnestad, Elisabeth Leere Øiestad, Mariana Dadalto Peres, Lena Kristoffersen, Vigdis Vindenes
Peripheral blood (PB) is considered to be the golden standard for measuring postmortem drug concentrations. In several cases, PB is however not available, but information regarding drug findings might still be crucial in order to determine the cause of death. Antidepressants are frequently detected in postmortem samples from forensic toxicology cases, but the literature investigating concentrations in other matrices than peripheral and heart blood is limited.We here describe a study for comparison of concentrations for a large number of different drugs in six different matrices...
May 14, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29747656/maternal-drug-use-and-the-risk-of-anorectal-malformations-systematic-review-and-meta-analysis
#4
REVIEW
Nadine Zwink, Ekkehart Jenetzky
BACKGROUND: Origin of anorectal malformations (ARM) are considered multifactorial. Several genetic and non-genetic risk factors are discussed in literature. Maternal periconceptional medical drug use as possible risk factor, however, has not been reviewed systematically. METHODS: Studies published between 1977 and April 2017 were reviewed through systematic search in PubMed, ISI Web of Knowledge and Scopus databases. Furthermore, related and cross-referencing publications were reviewed...
May 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29746436/the-relation-between-dosage-serum-concentrations-and-clinical-outcome-in-children-and-adolescents-treated-with-sertraline-a-naturalistic-study-erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#6
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738811/hypobaric-hypoxia-exposure-in-rats-differentially-alters-antidepressant-efficacy-of-the-selective-serotonin-reuptake-inhibitors-fluoxetine-paroxetine-escitalopram-and-sertraline
#7
Shami Kanekar, Chandni S Sheth, Hendrik J Ombach, Paul R Olson, Olena V Bogdanova, Matthew Petersen, Chloe E Renshaw, Young-Hoon Sung, Kristen E D'Anci, Perry F Renshaw
Treatment-resistant depression, a chronic condition that affects 30% of depressed patients on antidepressants, is highly linked to suicidal behavior. Chronic hypoxia exposure via living at altitude (hypobaric hypoxia) or with chronic hypoxic diseases is demographically linked to increased risk for depression and suicide. We previously demonstrated that housing rats at altitude for a week incrementally increases depression-like behavior in the forced swim test (FST) in females, but not males. In animal models, high altitude exposure reduces brain serotonin, and selective serotonin reuptake inhibitors (SSRIs) can lose efficacy when brain serotonin levels are low...
May 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29732211/efficacy-of-sertraline-and-gabapentin-in-the-treatment-of-urethral-pain-syndrome-retrospective-results-of-a-single-institutional-cohort
#8
Özer Ural Cakici, Nurullah Hamidi, Emre Ürer, Emrah Okulu, Onder Kayigil
Introduction: Urethral pain syndrome is a subgroup of chronic pelvic pain syndromes and comprises a relatively challenging patient group in urological practice. Several different treatments have been used for the management of the condition from a mostly empirical basis. In this article, we present the results of a small cohort of young male patients treated with sertraline and gabapentin therapy. Material and methods: The data of 52 patients was retrospectively evaluated and 31 patients' data was included in this study...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29727988/effects-of-waterborne-antidepressants-on-non-target-animals-living-in-the-aquatic-environment-a-review
#9
REVIEW
Pavla Sehonova, Zdenka Svobodova, Petra Dolezelova, Petra Vosmerova, Caterina Faggio
After application, antidepressants, like other pharmaceuticals, are excreted from human body in their native form or as metabolites and enter the aquatic environment via different pathways. As concentrations of antidepressant residues in water continue to increase, their effects on non-target animals are being discussed. The aim of this study is to summarize current knowledge about the effects of wateborne antidepressants on non-target animals living in surface waters - invertebrates, fish and amphibians. Selective serotonin reuptake inhibitors such as fluoxetine, sertraline, and citalopram have been found to effect behavior, reproduction, and development in both invertebrates and vertebrates...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727969/contamination-profiles-mass-loadings-and-sewage-epidemiology-of-neuropsychiatric-and-illicit-drugs-in-wastewater-and-river-waters-from-a-community-in-the-midwestern-united-states
#10
Allie J Skees, Katelyn S Foppe, Bommanna Loganathan, Bikram Subedi
In this study, residues of the neuropsychiatric and illicit drugs including stimulants, opioids, hallucinogens, antischizophrenics, sedatives, and antidepressants were determined in influent and effluent samples from a small wastewater treatment plant, a receiving creek, and river waters in the Four Rivers region of the Midwestern United States. Nineteen neuropsychiatric drugs, eight illicit drugs, and three metabolites of illicit drugs were detected and quantitated in the water samples using HPLC-MS/MS. Residual concentrations of the drugs varied from below the detection limit to sub-μg/L levels...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726758/pharmacotherapy-for-the-treatment-of-depression-in-patients-with-alzheimer-s-disease-a-treatment-resistant-depressive-disorder
#11
Madia Lozupone, Maddalena La Montagna, Francesca D'Urso, Carla Piccininni, Rodolfo Sardone, Vittorio Dibello, Gianluigi Giannelli, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Nicola Quaranta, Davide Seripa, Antonello Bellomo, Giancarlo Logroscino, Francesco Panza
Pharmacotherapy for the treatment of depressive disorders in Alzheimer's Disease (AD) represents a clinical challenge. pharmacological options are often attempted after a period of watchful waiting (8-12 weeks). monoaminergic antidepressant drugs have shown only modest or null clinical benefits, maybe because the etiology of depressive symptoms in ad patients is fundamentally different from that of nondemented subjects. Areas covered: The following article looks at the selective serotonin reuptake inhibitor sertraline, which is one of the most frequently studied antidepressant medications in randomized controlled trials (RCTs)...
May 4, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29723928/effect-of-abcb1-c3435t-polymorphism-on-pharmacokinetics-of-antipsychotics-and-antidepressants
#12
Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
P-glycoprotein, encoded by ABCB1, is an ATP-dependent drug efflux pump which exports substances outside the cell. Some studies described connections between C3435T polymorphism T allele and lower P-glycoprotein expression; therefore homozygous T/T could show higher plasma levels. Our aim was to evaluate the effect of C3435T on pharmacokinetics of 4 antipsychotics (olanzapine, quetiapine, risperidone and aripiprazole) and 4 antidepressants (trazodone, sertraline, agomelatine and citalopram). The study included 473 healthy volunteers receiving a single oral dose of one of these drugs, genotyped by real-time PCR...
May 3, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29723689/development-and-validation-of-a-test-to-identify-drugs-that-cause-idiosyncratic-drug-induced-liver-injury
#13
Andreas Benesic, Isabelle Rotter, Diana Dragoi, Sabine Weber, Marie-Luise Buchholtz, Alexander L Gerbes
BACKGROUND & AIMS: Idiosyncratic drug-induced liver injury (iDILI) is one of the most challenging diagnoses in hepatology. It is frequently impossible to identify the agent that has caused iDILI in patients who take multiple medicines. We developed an in vitro method to identify drugs that cause liver injury in patients, based on drug toxicity to monocyte-derived hepatocyte-like (MH) cells from patient blood samples. We then collected data on patients who were re-exposed to drugs found to be toxic in the MH test to validate test performance...
April 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29708207/ssri-associated-bruxism-a-systematic-review-of-published-case-reports
#14
REVIEW
Andrew R Garrett, Jason S Hawley
Purpose of review: Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports. Recent findings: Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29707579/cognitive-behavior-therapy-as-augmentation-for-sertraline-in-treating-patients-with-persistent-postural-perceptual-dizziness
#15
Yi-Chuan Yu, Hui Xue, Ying-Xin Zhang, Jiying Zhou
Background: Persistent postural-perceptual dizziness (PPPD) is a common vestibular disorder. This study was conducted to assess whether the addition of cognitive behavior therapy (CBT) could significantly improve the efficacy and acceptability of sertraline in treating PPPD. Methods: PPPD patients were recruited and randomly assigned to control and experiment groups. Patients in both groups received sertraline 50-200 mg/day, and only patients in the experiment group received CBT (twice a week, one hour per time)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29706306/psychiatric-comedication-in-patients-with-epilepsy
#16
Magdalena Bosak, Katarzyna Cyranka, Dominika Dudek, Monika Kowalik, Patrycja Mołek, Agnieszka Słowik
Psychiatric disorders are more common in patients with epilepsy than in the general population. The aims of the study were to assess the frequency and type of psychotropic drug usage in patients with epilepsy, to assess the risk factors for their use, and to assess their proconvulsive potential and the risk of interactions with antiepileptic drugs. This 20-month prospective study included patients treated at the university hospital outpatient clinic. Psychotropic drugs have been classified according to the Anatomical Therapeutic Chemical Classification System...
April 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29689343/leveraging-genetics-to-enhance-the-efficacy-of-ptsd-pharmacotherapies
#17
REVIEW
Mark W Miller
Progress in PTSD pharmacotherapy has lagged far behind that of other major mental illnesses. Unfortunately, due to the enormous costs and lengthy process involved in bringing drugs to market, delivering new treatments to patients with PTSD in the near future will remain a challenge. However, by capitalizing on recent advances in the pharmacogenetics of antidepressants, precision psychiatry approaches can be leveraged to optimize the delivery of currently-available medications in a fraction of the time and cost required to develop novel therapeutics...
April 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29688573/antidepressants-for-the-treatment-of-people-with-co-occurring-depression-and-alcohol-dependence
#18
REVIEW
Roberta Agabio, Emanuela Trogu, Pier Paolo Pani
BACKGROUND: Alcohol dependence is a major public health problem characterized by recidivism, and medical and psychosocial complications. The co-occurrence of major depression in people entering treatment for alcohol dependence is common, and represents a risk factor for morbidity and mortality, which negatively influences treatment outcomes. OBJECTIVES: To assess the benefits and risks of antidepressants for the treatment of people with co-occurring depression and alcohol dependence...
April 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29683701/exploring-evidence-of-a-dissociative-subtype-in-ptsd-baseline-symptom-structure-etiology-and-treatment-efficacy-for-those-who-dissociate
#19
Mark S Burton, Norah C Feeny, Arin M Connell, Lori A Zoellner
OBJECTIVE: With the inclusion of a dissociative subtype, recent changes to the DSM-5 diagnosis of posttraumatic stress disorder (PTSD) have emphasized the role of dissociation in the experience and treatment of the disorder. However, there is a lack of research exploring the clinical impact for highly dissociative groups receiving treatment for PTSD. The current study examined the presence and clinical impact of a dissociative subtype in a sample of individuals receiving treatment for chronic PTSD...
May 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29682241/drug-administration-adjustments-for-elderly-patients-with-dysphagia-a-case-report
#20
Patrícia de Carvalho Mastroianni, Marcela Forgerini
An elderly patient, aged 76 years, diagnosed with dysphagia, depression, hypothyroidism, Alzheimer's disease and mild cognitive deficit, was identified with sertraline and levothyroxine- drug-related problems. Medication Therapy Management (MTM) was used to adjust therapy to the patient's needs by macerating sertraline tablets and solubilizing them in 10-30 mL of orange juice. The patient was advised to take levothyroxine after fasting. Six months later, pharmaceutical follow-up identified an increase in the Mini-Mental State Exam score from 22 to 26 and a decrease in the Clinical Dementia Rating (CDR) scale score from 1...
January 2018: Dementia & Neuropsychologia
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