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https://www.readbyqxmd.com/read/29343694/sertraline-paroxetine-and-chlorpromazine-are-rapidly-acting-anthelmintic-drugs-capable-of-clinical-repurposing
#1
Janis C Weeks, William M Roberts, Caitlyn Leasure, Brian M Suzuki, Kristin J Robinson, Heather Currey, Phurpa Wangchuk, Ramon M Eichenberger, Aleen D Saxton, Thomas D Bird, Brian C Kraemer, Alex Loukas, John M Hawdon, Conor R Caffrey, Nicole F Liachko
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for anthelmintic activity against the soil nematode Caenorhabditis elegans. From this screen, we found that the neuromodulatory drugs sertraline, paroxetine, and chlorpromazine kill C. elegans at multiple life stages including embryos, developing larvae and gravid adults...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325311/-effects-of-trimetazidine-a-myocardial-metabolism-agent-on-regulating-5-hydroxytrytamine-system-of-rats-with-myocardial-infarction-and-or-depression
#2
(no author information available yet)
Objective: 5-Hydroxytrytamine (5-HT) system was reported to be associated with myocardial infarction (MI) and depression. The aim of the present study was to study the effect of trimetazidine on 5-HT in MI and/or depression rats. Methods: Ninety rats were divided into three groups: trimetazidine, sertraline and saline groups (n=30 in each group), and pretreated with trimetazidine, sertarline, or saline, respectively, by gavage once a day for 4 weeks. Thereafter, each group was further divided into three subgroups: MI subgroup, depression subgroup, and MI+ depression subgroup...
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29287236/moderators-and-predictors-of-response-to-cognitive-behaviour-therapy-for-pediatric-obsessive-compulsive-disorder-a-systematic-review
#3
Cynthia Turner, Beth O'Gorman, Archana Nair, Richard O'Kearney
We report a systematic review of moderators of CBT efficacy for pediatric OCD relative to other treatments. CENTRAL, MEDLINE, EMBASE, CINAHL, and PsycINFO were searched for RCTs reporting on effect moderation for CBT outcomes. Five studies (N = 365) examined 17 variables with three significant moderators identified. Compared to pill-placebo, CBT monotherapy was not effective for children with a family history of OCD but was for those without a family history. For children with a family history, CBT plus sertraline efficacy was attenuated but remained significant...
December 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29286926/effects-of-in-utero-exposure-to-selective-serotonin-reuptake-inhibitors-and-venlafaxine-on-term-and-preterm-infants
#4
A N Hogue, M E Temple-Cooper, M Lagzdins, S Worley, J Scwersenski, R Floyd, F Saker
OBJECTIVE: We hypothesized that in-utero SSRI exposure affects Apgar scores and immediate post-delivery oxygen requirements. STUDY DESIGN: SSRI in-utero exposure was assessed retrospectively in preterm neonates ≥ 28 weeks gestation and term neonates. Primary outcome was Apgar <7 at five minutes and delivery room oxygen requirements. Secondary endpoints included one-minute Apgar, length of stay, birth weight, and NICU admission. RESULTS: Fifty-one preterm and 117 term neonates were exposed to a SSRI; mostly to sertraline...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29276648/sertraline-induced-hemichorea
#5
Emilia M Gatto, Victoria Aldinio, Virginia Parisi, Gabriel Persi, Gustavo Da Prat, Maria Bres Bullrich, Pilar Sanchez, Galeno Rojas
Background: Hemichorea-hemiballism is a syndrome secondary to different etiologies. Drug-induced hemichorea is a rare syndrome related to selective serotonin reuptake inhibitors. To the best of our knowledge, no previous cases of hemichorea associated with sertraline have been reported. Case Report: A 65-year-old female noticed hemichorea 1 week after initiation of sertraline. After extensive investigations, other causes of hemichorea were excluded. Hemichorea remitted after sertraline withdrawal...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29276354/multidimensional-approaches-for-a-case-of-severe-adult-obsessive-compulsive-disorder
#6
Zhongyong Shi, Xinchun Mei, Yingbo Zhu, Yu Shuai, Yupeng Chen, Yujie Wu, Yuan Shen
Obsessive-compulsive disorder (OCD) is a chronic, distressing and substantially impairing neuropsychiatric disorder, characterized by obsessions or compulsions. The current case describes a 44-year-old adult female diagnosed with OCD. The patient had an incomplete response to several SSRIs alone during her past treatment, and led a poor-quality life for at least three years. Current multidimensional approaches, including combined cognitive behavioral therapy (CBT) and the Selective Serotonin Reuptake Inhibitor (SSRI, Sertraline) with a small dose of antipsychotics (Aripiprazole) for augmentation, as well as familial support and resources from the internet were provided for the patient for six months...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29273901/systematic-review-of-combined-pharmacotherapy-for-the-treatment-of-alcohol-use-disorder-in-patients-without-comorbid-conditions
#7
REVIEW
Andrew C Naglich, Austin Lin, Sidarth Wakhlu, Bryon H Adinoff
BACKGROUND: Previous reviews have examined the use of theoretically supported combinations of drugs for the treatment of alcohol use disorder. This review seeks to examine the strengths and limitations of current clinical evidence for the use of combined pharmacological interventions intended to treat alcohol use disorder. OBJECTIVES: The objective of this review was to identify combinations of pharmacological treatments for alcohol use disorder, and assess the strength of clinical evidence for these treatments...
December 22, 2017: CNS Drugs
https://www.readbyqxmd.com/read/29259144/antidepressants-for-depression-associated-with-traumatic-brain-injury-a-meta-analytical-study-of-randomised-controlled-trials
#8
A Paraschakis, A H Katsanos
INTRODUCTION: Depression following traumatic brain injury is experienced by 16% to 60% of affected patients. The present study aimed to update the best evidence-based pharmacological treatments for tackling such chronic and debilitating disorders. METHODS: We systematically reviewed and meta-analysed randomised controlled trials published from 1990 until August 2017 that compared the efficacy of antidepressants with placebo in the treatment of post-traumatic brain injury depression...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29244076/reference-brain-blood-concentrations-of-citalopram-duloxetine-mirtazapine-and-sertraline
#9
Michael Nedahl, Sys Stybe Johansen, Kristian Linnet
Postmortem blood samples may not accurately reflect antemortem drug concentrations, as the levels of some drugs increase due to postmortem redistribution (PMR). The brain has been suggested as an alternative sampling site. The anatomically secluded site of the brain limits redistribution and prolongs the detection window, thereby enabling sampling from deceased individuals where blood is no longer suitable for analysis. We report concentrations in brain tissue and blood from 91 cases for the four antidepressants citalopram, duloxetine, mirtazapine and sertraline...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29241359/antidepressant-outcomes-predicted-by-genetic-variation-in-corticotropin-releasing-hormone-binding-protein
#10
Chloe P O'Connell, Andrea N Goldstein-Piekarski, Charles B Nemeroff, Alan F Schatzberg, Charles Debattista, Tania Carrillo-Roa, Elisabeth B Binder, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Leanne M Williams
OBJECTIVE: Genetic variation within the hypothalamic-pituitary-adrenal (HPA) axis has been linked to risk for depression and antidepressant response. However, these associations have yet to produce clinical gains that inform treatment decisions. The authors investigated whether variation within HPA axis genes predicts antidepressant outcomes within two large clinical trials. METHOD: The test sample comprised 636 patients from the International Study to Predict Optimized Treatment in Depression (iSPOT-D) who completed baseline and 8-week follow-up visits and for whom complete genotyping data were available...
December 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29235396/brain-derived-neurotrophic-factor-bdnf-serum-level-in-women-with-first-episode-depression-correlation-with-clinical-and-metabolic-parameters
#11
Maria Skibinska, Pawel Kapelski, Aleksandra Rajewska-Rager, Joanna Pawlak, Aleksandra Szczepankiewicz, Beata Narozna, Joanna Twarowska-Hauser, Monika Dmitrzak-Weglarz
BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences neuron differentiation during development, as well as the synaptic plasticity and neuron survival in adulthood. BDNF has been implicated in the pathogenesis of psychiatric disorders and its serum level is a potential biomarker for depression. The aim of this study was to examine serum levels of BDNF in first-episode depression and its correlation with clinical and metabolic parameters. MATERIALS AND METHODS: The study was performed on a group of 60 women: 30 diagnosed with a first-episode of depression and 30 healthy controls...
December 13, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29233783/transcranial-direct-current-stimulation-of-20-and-30-minutes-combined-with-sertraline-for-the-treatment-of-depression
#12
Elena L Pavlova, Alexandra A Menshikova, Roman V Semenov, Ekaterina N Bocharnikova, Galina N Gotovtseva, Tatiana A Druzhkova, Anna G Gersamia, Anna A Gudkova, Alla B Guekht
BACKGROUND: Transcranial direct current stimulation (tDCS) can be an effective treatment for depression, however, the duration of the stimulation session, among other parameters, needs to be optimized. METHODS: 69 mild to moderately depressed patients (age 37.6±10.5years, 19 men) were randomized into three groups - 30-, 20-minute or sham tDCS. 10 daily sessions of anodal/sham tDCS of the left DLPFC (0.5mA; electrode 3,5×7cm) combined with 50mg/day of sertraline were performed...
December 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29208964/reduced-anxiety-is-associated-with-the-accumulation-of-six-serotonin-reuptake-inhibitors-in-wastewater-treatment-effluent-exposed-goldfish-carassius-auratus
#13
D B D Simmons, E S McCallum, S Balshine, B Chandramouli, J Cosgrove, J P Sherry
Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205633/a-combined-connectivity-mapping-and-pharmacoepidemiology-approach-to-identify-existing-medications-with-breast-cancer-causing-or-preventing-properties
#14
John Busby, Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Chris R Cardwell
PURPOSE: We applied a novel combined connectivity mapping and pharmacoepidemiological approach to identify medications that alter breast cancer risk. METHODS: The connectivity mapping process identified 6 potentially cancer-causing (meloxicam, azithromycin, rizatriptan, citalopram, rosiglitazone, and verapamil) and 4 potentially cancer-preventing (bendroflumethiazide, sertraline, fluvastatin, and budesonide) medications that were suitable for pharmacoepidemiological investigation...
December 4, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29202289/concentrating-mixtures-of-neuroactive-pharmaceuticals-and-altered-neurotransmitter-levels-in-the-brain-of-fish-exposed-to-a-wastewater-effluent
#15
Arthur David, Anke Lange, Charles R Tyler, Elizabeth M Hill
Fish can be exposed to a variety of neuroactive pharmaceuticals via the effluent discharges from wastewater treatment plants and concerns have arisen regarding their potential impacts on fish behaviour and ecology. In this study, we investigated the uptake of 14 neuroactive pharmaceuticals from a treated wastewater effluent into blood plasma and brain regions of roach (Rutilus rutilus) after exposure for 15days. We show that a complex mixture of pharmaceuticals including, 6 selective serotonin reuptake inhibitors, a serotonin-noradrenaline reuptake inhibitor, 3 atypical antipsychotics, 2 tricyclic antidepressants and a benzodiazepine, concentrate in different regions of the brain including the telencephalon, hypothalamus, optic tectum and hindbrain of effluent-exposed fish...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29198213/presence-of-neuroticism-and-antidepressant-remission-rates-in-late-life-depression-results-from-the-neurobiology-of-late-life-depression-nbold-study
#16
David C Steffens, Rong Wu, James J Grady, Kevin J Manning
Neuroticism in older adults is common yet understudied, particularly its effects on depression treatment outcomes. We hypothesized that presence of high neuroticism would be associated with lower 12-week remission rates in older depressed sertraline-treated patients. In this longitudinal cohort study, 43 depressed older adults completed the Revised NEO Personality Inventory (NEO PI-R). A study psychiatrist administered the Montgomery Ǻsberg Depression Rating Scale (MADRS), and the Cumulative Illness Rating Scale (CIRS, a measure of medical burden) at baseline, and the MADRS at each clinical visit...
December 4, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29197244/systematic-assessment-of-different-solvents-for-the-extraction-of-drugs-of-abuse-and-pharmaceuticals-from-an-authentic-hair-pool
#17
Milena M Madry, Thomas Kraemer, Markus R Baumgartner
Hair analysis has been established as a prevalent tool for retrospective drug monitoring. In this study, different extraction solvents for the determination of drugs of abuse and pharmaceuticals in hair were evaluated for their efficiency. A pool of authentic hair from drug users was used for extraction experiments. Hair was pulverized and extracted in triplicate with seven different solvents in a one- or two-step extraction. Three one- (methanol, acetonitrile, and acetonitrile/water) and four two-step extractions (methanol two-fold, methanol and methanol/acetonitrile/formate buffer, methanol and methanol/formate buffer, and methanol and methanol/hydrochloric acid) were tested under accurately equal experimental conditions...
November 23, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29196989/mixed-approach-retrospective-analyses-of-suicide-and-suicidal-ideation-for-brand-compared-with-generic-central-nervous-system-drugs
#18
Ning Cheng, Md Motiur Rahman, Yasser Alatawi, Jingjing Qian, Peggy L Peissig, Richard L Berg, C David Page, Richard A Hansen
INTRODUCTION: Several different types of drugs acting on the central nervous system (CNS) have previously been associated with an increased risk of suicide and suicidal ideation (broadly referred to as suicide). However, a differential association between brand and generic CNS drugs and suicide has not been reported. OBJECTIVES: This study compares suicide adverse event rates for brand versus generic CNS drugs using multiple sources of data. METHODS: Selected examples of CNS drugs (sertraline, gabapentin, zolpidem, and methylphenidate) were evaluated via the US FDA Adverse Event Reporting System (FAERS) for a hypothesis-generating study, and then via administrative claims and electronic health record (EHR) data for a more rigorous retrospective cohort study...
December 2, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29192458/-exploring-the-clinical-characters-of-shugan-jieyu-capsule-through-text-mining
#19
Zheng-Ping Pu, Jiang-Ming Xia, Wei Xie, Jin-Cai He
The study was main to explore the clinical characters of Shugan Jieyu capsule through text mining. The data sets of Shugan Jieyu capsule were downloaded from CMCC database by the method of literature retrieved from May 2009 to Jan 2016. Rules of Chinese medical patterns, diseases, symptoms and combination treatment were mined out by data slicing algorithm, and they were demonstrated in frequency tables and two dimension based network. Then totally 190 literature were recruited. The outcomess suggested that SC was most frequently correlated with liver Qi stagnation...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29185803/better-tolerance-of-citalopram-in-a-breastfed-infant-who-could-not-tolerate-sertraline-and-paroxetine
#20
Faruk Uguz
Postpartum depression is frequently observed in women. First-line antidepressants in treatment of postpartum depression are selective serotonin reuptake inhibitors (SSRIs). Although SSRIs are well tolerated by most breastfed infants, some adverse events may arise in exposed infants. This report presents the case of an infant of a breastfeeding woman using citalopram without any problem after sertraline and paroxetine were discontinued due to adverse events in the infant.
November 29, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
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