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https://www.readbyqxmd.com/read/28088112/a-current-perspective-on-the-oncopreventive-and-oncolytic-properties-of-selective-serotonin-reuptake-inhibitors
#1
REVIEW
Daniel P Radin, Parth Patel
Current cancer research strongly focuses on identifying novel pathways that can be selectively exploited in the clinic and identifying drugs capable of exploiting cancer vulnerabilities. Occasionally, drugs identified to exploit a cancer-specific vulnerability are on the market for clinical indications in another disease area. Rebranding them as anti-cancer drugs is a process commonly referred to as drug repurposing and is typically a faster method than bringing a novel drug to market. Selective serotonin reuptake inhibitors (SSRIs) are primarily used for treating several types of depression, but over the past two decades mounting evidence suggests that drugs in this class have oncolytic properties and reduce the risk of certain cancers...
January 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076642/activity-rest-rhythm-of-depressed-adolescents-undergoing-therapy-case-studies
#2
Maria Eugênia Mesquita, Maria Eliza Finazzi, Bruno Gonçalves, Lee Fu-I, Leandro L Duarte, José Ricardo Lopes, José Alberto Del-Porto, Luiz Menna-Barreto
Introduction: Disorders of circadian rhythms have been reported in studies of both depressed children and of depressed adolescents. The aim of this study was to evaluate whether there is a relationship between the 24-hour spectral power (24h SP) of the activity/rest rhythm and the clinical course of depression in adolescents. Methods: Six 14 to 17-year-old adolescents were recruited for the study. They were all suffering from major depressive disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, as identified by the Schedule for Affective Disorders and Schizophrenia for School Aged Children: Present and Lifetime Version (K-SADS-PL)...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28074989/-antidepressants-agents-in-breast-cancer-patients-using-tamoxifen-review-of-basic-and-clinical-evidence
#3
María Elisa Irarrázaval O, Leonardo Gaete G
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed to women with breast cancer not only for depression, but also for anxiety and hot flashes. Some AD are substrates or inhibitors of the Tmf metabolic pathway. Therefore there may be interactions when Tmf and AD are prescribed simultaneously. Oncologic protection afforded by Tmf may become less effective or null when AD are indicated, especially in poor metabolizing patients...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28066013/premenstrual-dysphoric-disorder-general-overview-treatment-strategies-and-focus-on-sertraline-for-symptom-onset-dosing
#4
Chittaranjan Andrade
No abstract text is available yet for this article.
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28052847/subcellular-partitioning-and-intra-macrophage-selectivity-of-antimicrobial-compounds-against-mycobacterium-tuberculosis
#5
Michael D Schump, Douglas M Fox, Carolyn R Bertozzi, Lee W Riley
The efficacy of antimicrobial drugs against Mycobacterium tuberculosis (Mtb), an intracellular bacterial pathogen, is generally first established by testing compounds against bacteria in axenic culture. However, inside of infected macrophages bacteria encounter an environment which differs substantially from broth culture and are subject to important host-dependent pharmacokinetic phenomena which modulate drug activity. Here we describe how pH dependent partitioning drives asymmetric antimicrobial drug distribution in Mtb infected macrophages...
January 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28050183/the-effects-of-sertraline-in-controlling-refractory-hypertension-in-women-with-premenstrual-syndrome
#6
Fatemeh Ranjbar, Fariborz Akbarzadeh, Mahboub Asadlou
Objective: The aim of this study was to evaluate the effect of Premenstrual Syndrome (PMS) treatment with selective serotonin reuptake inhibitor (SSRI) on treatment response of refractory hypertension of the patients. Method: This was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and PMS at the same time. We obtained informed consent from 40 patients who had inclusion criteria and selected 20 patients for the intervention (sertraline 50 mg daily) and 20 for the control groups...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28045289/temporal-precedence-in-the-identification-of-mediators-of-change-a-brief-comment-on-mediators-of-change-in-the-child-adolescent-multimodal-treatment-study-kendall-et-al-2016
#7
Scott T Gaynor
OBJECTIVE: Comment on the issue of temporal precedence and the implications for interpreting the results of the mediation analyses in the Child/Adolescent Multimodal Treatment Study. METHOD: Review of Kendall et al. (2016). RESULTS: Kendall et al. reported that residualized (baseline to posttreatment) change in coping efficacy, but not anxious self-talk, mediated residualized (baseline to follow-up) change in anxiety symptoms in cognitive-behavior therapy (CBT), sertraline (SRT), and CBT + SRT compared to placebo...
January 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28043905/association-of-liver-injury-from-specific-drugs-or-groups-of-drugs-with-polymorphisms-in-hla-and-other-genes-in-a-genome-wide-association-study
#8
Paola Nicoletti, Guruprasad P Aithal, Einar S Bjornsson, Raul J Andrade, Ashley Sawle, Marco Arrese, Huiman X Barnhart, Emmanuelle Bondon-Guitton, Paul H Hayashi, Fernando Bessone, Alfonso Carvajal, Ingolf Cascorbi, Elizabeth T Cirulli, Naga Chalasani, Anita Conforti, Sally A Coulthard, Mark J Daly, Christopher P Day, John F Dillon, Robert J Fontana, Jane I Grove, Pär Hallberg, Nelia Hernández, Luisa Ibáñez, Gerd A Kullak-Ublick, Tarja Laitinen, Dominique Larrey, M Isabel Lucena, Anke H Maitland-van der Zee, Jennifer H Martin, Mariam Molokhia, Munir Pirmohamed, Elizabeth E Powell, Shengying Qin, Jose Serrano, Camilla Stephens, Andrew Stolz, Mia Wadelius, Paul B Watkins, Aris Floratos, Yufeng Shen, Matthew R Nelson, Thomas J Urban, Ann K Daly
BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS: We performed a GWAS of 862 persons with DILI and 10588 population-matched controls. The first set of cases was recruited prior to May 2009 in Europe (n=137) or the USA (n=274). The second set of cases were identified from May 2009 through May 2013 from international collaborative studies performed in Europe, the USA and South America...
December 30, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28034283/in-silico-studies-revealed-multiple-neurological-targets-for-the-antidepressant-molecule-ursolic-acid
#9
Rajeev K Singla, Luciana Scotti, Ashok K Dubey
BACKGROUND: Ursolic acid, a bioactive pentacyclic triterpenoid had been evaluated for its interaction with the neurological targets associated with antidepressant drugs. Current study was to mechanistically analyze the probable site of action for ursolic acid on the target proteins. METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology. RESULTS: Results revealed its non-selective antidepressant action with strong binding affinity towards LeuT and MAO-A proteins, which was found to be comparable with the reference ligands like chlorgyline, clomipramine, sertraline and deprenyl / selegiline...
December 29, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/28013355/effect-of-sildenafil-on-the-activity-of-some-antidepressant-drugs-and-electroconvulsive-shock-treatment-in-the-forced-swim-test-in-mice
#10
Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Piotr Wlaź
Sildenafil, a potent and selective inhibitor of phosphodiesterase type 5, is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. It is often taken by patients suffering from depression and receiving antidepressant drug treatment. However, its influence on the efficacy of antidepressant treatment was not sufficiently studied. Therefore, the aim of the present study was to investigate the influence of sildenafil on the anti-immobility action of several antidepressant drugs (i.e...
December 24, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28012414/the-effect-of-sertraline-and-8-oh-dpat-on-the-ptz_induced-seizure-threshold-role-of-the-nitrergic-system
#11
Azhdar Heydari, Shima Davoudi
PURPOSE: Serotonin is a key regulatory neurotransmitter in the CNS which plays an important role in seizure through different receptors, especially the 5HT1A subtype. The role of sertraline through the 5HT1A receptor and nitric oxide interaction on the PTZ-induced seizure threshold was investigated in this study. METHOD: In this study, 70 white male mice were randomly divided into 10 groups including intact control, sham-control and eight experimental groups which received sertraline, 8-OH-DPAT, WAY100635, WAY100635+sertraline, WAY100635+8-OH-DPAT, L-NAME, L-NAME+sertraline and L-NAME+8-OH-DPAT...
December 15, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28010130/treatment-of-alcohol-use-disorder-and-co-occurring-ptsd
#12
Mandrill Taylor, Ismene Petrakis, Elizabeth Ralevski
BACKGROUND: Alcohol use disorder (AUD) is a serious psychiatric disorder with medical, psychiatric, and social consequences. In individuals with comorbid post-traumatic stress disorder (PTSD), treatment outcomes are notably worse in comparison with treatment outcomes associated with either disorder occurring alone. There is a growing literature evaluating treatments, both pharmacotherapy and psychotherapy focused, in individuals with co-occurring AUD and PTSD. The main objective of this review was to evaluate pharmacotherapy and psychotherapy studies that were specifically designed to evaluate the treatment of individuals with comorbid AUD and PTSD...
December 23, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28005135/psychopharmacotherapy-in-pregnancy-and-breastfeeding
#13
Salvatore Giovanni Vitale, Antonio Simone Laganà, Maria Rosaria Anna Muscatello, Valentina Lucia La Rosa, Veronica Currò, Gianluca Pandolfo, Rocco Antonio Zoccali, Antonio Bruno
Importance: Fifteen percent to 20% of pregnant women suffer from mental disorders, and 86% of them are not treated due to potential teratogenic risks for the fetus. Several drugs seem to be safe during pregnancy but knowledge regarding risks of antenatal exposure to drugs is still limited. Objective: The aim of this article is to provide a review of literature, data, and a clinical guideline concerning the treatment and management of mental disorders during pregnancy and lactation...
December 2016: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/27976631/sertraline-induced-reproductive-toxicity-in-male-rats-evaluation-of-possible-underlying-mechanisms
#14
Ozlem Atli, Merve Baysal, Gozde Aydogan-Kilic, Volkan Kilic, Seyda Ucarcan, Burak Karaduman, Sinem Ilgin
This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted...
December 13, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27976164/nepeta-menthoides-boiss-buhse-freeze-dried-aqueous-extract-versus-sertraline-in-the-treatment-of-major-depression-a-double-blind-randomized-controlled-trial
#15
S Kolouri, A Firoozabadi, A Salehi, M M Zarshenas, S A Dastgheib, M Heydari, H Rezaeizadeh
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27966486/selective-serotonin-reuptake-inhibitor-sertraline-inhibits-voltage-dependent-k-channels-in-rabbit-coronary-arterial-smooth-muscle-cells
#16
Han Sol Kim, Hongliang Li, Hye Won Kim, Sung Eun Shin, Il-Whan Choi, Amy L Firth, Hyoweon Bang, Young Min Bae, Won Sun Park
We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline decreased the Kv channel current in a dose-dependent manner, with an IC50 value of 0.18 mu M and a slope value (Hill coefficient) of 0.61. Although the application of 1 mu M sertraline did not affect the steady-state activation curves, sertraline caused a significant, negative shift in the inactivation curves...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27966422/-rhabdomyolysis-after-lifting-ikea-bags-in-a-man-using-sertraline
#17
Ingvild Kummen, Thomas Giver Jensen
We present a case of a 28-year-old male, using sertraline, who experienced progressive oedema in both upper extremities after having lifted two IKEA bags weighing 20 kg each from his car up to the third floor. Blood creatine kinase (CK) level was measured 5,260 U/l, and the patient was admitted for oral rehydration with the diagnosis rhabdomyolysis. The MRI showed swelling in the triceps muscles and latissimus dorsi muscles resulting in compression of the brachial vein. We discuss the pathomechanism behind the increased CK level and the swelling, and the possible effect sertraline may have had on the development of rhabdomyolysis...
December 12, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27938775/a-woman-in-her-60s-with-fever-and-altered-mental-status-in-a-psychiatric-hospital
#18
Benjamin C Kalivas, Andrew J Goodwin
A woman in her 60s with a history of hepatitis C with cirrhosis and major depressive disorder with psychotic features was admitted to the inpatient psychiatric unit for suicidal ideation. She was initially treated with a combination of sertraline and paliperidone. The paliperidone was subsequently changed to risperidone and ultimately to olanzapine. She developed worsening mental status and was then treated for catatonia with benzodiazepines. Over 2 days, her mental status continued to worsen and she developed fever and tachycardia...
December 2016: Chest
https://www.readbyqxmd.com/read/27930704/in-vitro-antifungal-activity-of-sertraline-and-synergistic-effects-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-clinical-trichosporon-asahii-isolates
#19
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is the major pathogen of invasive trichosporonosis which occurred mostly in immunocompromised patients. The biofilms formation ability of T. asahii may account for resistance to antifungal drugs and results a high mortality rate. Sertraline, a commonly prescribed antidepressant, has been demonstrated to show in vitro and in vivo antifungal activities against many kinds of pathogenic fungi, especially Cryptococcus species. In the present study, the in vitro activities of sertraline alone or combined with fluconazole, voriconazole, itraconazole, caspofungin and amphotericin B against planktonic forms and biofilms of 21 clinical T...
2016: PloS One
https://www.readbyqxmd.com/read/27928252/effects-of-passion-flower-extract-as-an-add-on-treatment-to-sertraline-on-reaction-time-in-patients-%C3%A2-with-generalized-anxiety-disorder-a-double-blind-placebo-controlled-study
#20
Mandana Nojoumi, Padideh Ghaeli, Samrand Salimi, Ali Sharifi, Firoozeh Raisi
Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software...
July 2016: Iranian Journal of Psychiatry
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