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osteoarthritis and obesity

Mamdooh Abdullah Gari, Mohammed AlKaff, Haneen S Alsehli, Ashraf Dallol, Abdullah Gari, Muhammad Abu-Elmagd, Roaa Kadam, Mohammed F Abuzinadah, Mazin Gari, Adel M Abuzenadah, Kalamegam Gauthaman, Heba Alkhatabi, Mohammed M Abbas
BACKGROUND: Osteoarthritis (OA) is a progressive joint disease characterized by gradual degradation of extracellular matrix (ECM) components in the cartilage and bone. The ECM of cartilage is a highly specified structure that is mainly composed of type II collagen and provides tensile strength to the tissue via aggrecan and proteoglycans. However, changes in the ECM composition and structure can lead to loss of collagen type II and network integrity. Several risk factors have been correlated with OA including age, genetic predisposition, hereditary factors, obesity, mechanical injuries, and joint trauma...
October 10, 2016: BMC Medical Genetics
Behzad Heidari, Karimollah Hajian-Tilaki, Mansour Babaei
BACKGROUND: Several factors are associated with the development or exacerbation of pain in knee osteoarthritis (KOA). In this study, we reviewed this context based on relevant studies. METHODS: Recent published studies which have addressed the relationship between pain and KOA were summarized. RESULTS: Correlates of the clinical, demographic features, laboratory tests and abnormalities on radiographic as well as magnetic resonance imaging (MRI) with the knee pain have been discussed...
2016: Caspian Journal of Internal Medicine
Wei-Jei Lee
Obesity is a pan-endemic health problem in both developed and developing countries, in both western and eastern countries. It increases risk for many common diseases, including type 2 diabetes, dyslipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, osteoarthritis, cancers and depression etc.. Although the incidence of obesity in Asia is relatively low, Asian patients tend to have similar incidence of obesity related metabolic syndrome at lower BMI level comparing to Caucasians because of central obesity...
September 2016: Journal of Hypertension
Nicolas Reina, Etienne Cavaignac, Régis Pailhé, Aymeric Pailliser, Nicolas Bonnevialle, Pascal Swider, Jean-Michel Laffosse
Overweight is a risk factor for osteoarthritis on the knees. Subchondral trabecular bone (SCTB) densification has been shown to be associated with cartilage degeneration. This study analyzed the microarchitectural changes in the SCTB of tibial plateaus to validate the hypothesis that the degree of remodeling is correlated with a patient's body weight. Twenty-one tibial plateaus were collected during total knee arthroplasty from 21 patients (15 women and 6 men). These patients had a mean age of 70.4 years (49-81), mean weight of 74...
October 17, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Terry K Morgan, Emilie Jensen, Jeong Lim, Russell Riggs
BACKGROUND: Intra-articular hyaluronic acid (HA) injection is an intermediate option between analgesics and knee joint replacement in patients with osteoarthritis (OA). Our objective was to test whether image-guided HA injections may improve knee OA outcomes after 6 months of treatment independent of potential covariates. METHODS: This is a retrospective case series with multivariate outcome-based analysis of 207 consecutive adult patients with mild to severe knee OA treated at a single out-patient clinic employing fluoroscopy-guided HA injections...
December 2015: Sports Medicine—Open
Chandra Prakash Pal, Pulkesh Singh, Sanjay Chaturvedi, Kaushal Kumar Pruthi, Ashok Vij
BACKGROUND: Among the chronic rheumatic diseases, hip and knee osteoarthritis (OA) is the most prevalent and is a leading cause of pain and disability in most countries worldwide. Its prevalence increases with age and generally affects women more frequently than men. OA is strongly associated with aging and heavy physical occupational activity, a required livelihood for many people living in rural communities in developing countries. Determining region-specific OA prevalence and risk factor profiles will provide important information for planning future cost effective preventive strategies and health care services...
September 2016: Indian Journal of Orthopaedics
Sunderajhan Sekar, Ross Crawford, Yin Xiao, Indira Prasadam
Osteoarthritis is a progressive, age-related disease characterized by the degradation of the cartilage, abnormal bone remodelling, and joint pain eventually leading to disability. The occurrence of clinically diagnosed OA and the incidence of disability show geographic variations, which suggests that lifestyle and factors such as diet play a vital role in the formation and progression of OA. Obesity is associated with a state of low-grade inflammation and increased plasma concentrations of fatty acids such as the saturated fatty acids (SFA)...
October 13, 2016: Journal of Cellular Biochemistry
Johanne Martel-Pelletier, Andrew J Barr, Flavia M Cicuttini, Philip G Conaghan, Cyrus Cooper, Mary B Goldring, Steven R Goldring, Graeme Jones, Andrew J Teichtahl, Jean-Pierre Pelletier
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a multifactorial disease that affects the whole joint. An intricate relationship between local and systemic factors modulates its clinical and structural presentations, leading to a common final pathway of joint destruction...
October 13, 2016: Nature Reviews. Disease Primers
A Dell'Isola, R Allan, S L Smith, S S P Marreiros, M Steultjens
BACKGROUND: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. METHODS: The aim of this study is to identify the current evidence for the existence of groups of variables which point towards the existence of distinct clinical phenotypes in the KOA population. A systematic literature search in PubMed was conducted...
October 12, 2016: BMC Musculoskeletal Disorders
Jeffrey B Driban, Alina C Stout, Grace H Lo, Charles B Eaton, Lori Lyn Price, Bing Lu, Mary F Barbe, Timothy E McAlindon
BACKGROUND: We evaluated agreement among several definitions of accelerated knee osteoarthritis (AKOA) and construct validity by comparing their individual associations with injury, age, obesity, and knee pain. METHODS: We selected knees from the Osteoarthritis Initiative that had no radiographic knee osteoarthritis [Kellgren-Lawrence (KL) 0 or 1] at baseline and had high-quality quantitative medial joint space width (JSW) measures on two or more consecutive visits (n = 1655 knees, 1143 participants)...
October 2016: Therapeutic Advances in Musculoskeletal Disease
Anna Koskinen-Kolasa, Katriina Vuolteenaho, Riku Korhonen, Teemu Moilanen, Eeva Moilanen
BACKGROUND: Previous studies provide evidence that adipokine leptin increases production of catabolic and proinflammatory factors in chondrocytes and serves as a link between obesity and osteoarthritis (OA). However, the magnitude of the response to leptin treatment varies greatly between chondrocytes from different donor patients. In the present study, we investigated the regulatory role of suppressor of cytokine signaling-3 (SOCS-3) in the leptin-induced responses in OA cartilage. METHODS: Cartilage and synovial fluid samples from 97 patients with OA undergoing knee replacement surgery were collected...
October 3, 2016: Arthritis Research & Therapy
Rebecca Moyer, Wolfgang Wirth, Felix Eckstein
OBJECTIVE: To investigate the interaction between malalignment and body mass index (BMI) on cartilage thickness change in patients with knee osteoarthritis (OA). METHODS: Femorotibial cartilage thickness was measured from baseline to 2-years in 558 knees with radiographic OA. Cartilage thickness was determined in the central weight-bearing medial (cMFTC) and lateral (cLFTC) compartments. Femorotibial angle (FTA) was stratified into neutral, minor and definite malalignment...
October 1, 2016: Arthritis Care & Research
Elizabeth Salt, Amanda T Wiggins, Mary Kay Rayens, Brent J Morris, David Mannino, Andrew Hoellein, Ryan P Donegan, Leslie J Crofford
OBJECTIVE: Inconclusive findings about infection risks, importantly the use of immunosuppressive medications in patients who have undergone large-joint total joint arthroplasty, challenge efforts to provide evidence-based perioperative total joint arthroplasty recommendations to improve surgical outcomes. Thus, the aim of this study was to describe risk factors for developing a post-operative infection in patients undergoing TJA of a large joint (total hip arthroplasty, total knee arthroplasty, or total shoulder arthroplasty) by identifying clinical and demographic factors, including the use of high-risk medications (i...
August 24, 2016: Seminars in Arthritis and Rheumatism
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C Barrow, Baoji Xu, Michael D Cameron, Theodore M Kamenecka, Anutosh Chakraborty
OBJECTIVE: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inositol pyrophosphate (5-IP7) biosynthetic enzyme, inositol hexakisphosphate kinase-1 (IP6K1), protects mice from high fat diet (HFD) induced obesity (DIO) and insulin resistance. Yet, whether this pathway is a valid pharmacologic target in obesity/T2D is not known...
October 2016: Molecular Metabolism
Kate M O'Brien, Amanda Williams, John Wiggers, Luke Wolfenden, Serene Yoong, Elizabeth Campbell, Steven J Kamper, James McAuley, John Attia, Chris Oldmeadow, Christopher M Williams
Background: These trials are the first randomised controlled trials of telephone-based weight management and healthy lifestyle interventions for low back pain and knee osteoarthritis. This article describes the protocol and statistical analysis plan. Method: These trials are parallel randomised controlled trials that investigate and compare the effect of a telephone-based weight management and healthy lifestyle intervention for improving pain intensity in overweight or obese patients with low back pain or knee osteoarthritis...
September 13, 2016: Brazilian Journal of Physical Therapy
Sladjana Vasilic-Brasnjevic, Jelena Marinkovic, Hristina Vlajinac, Nadja Vasiljevic, Branko Jakovljevic, Marina Nikic, Milos Maksimovic
AIM: The aim of the present study was to investigate the association of the body mass index (BMI) and waist circumference (WC) with the severity of radiographic severity of knee osteoarthritis (rKOA) Methods. A cross-sectional study had been applied during the research which included 150 patients diagnosed at the General Hospital in Užice and Health Center in Arilje (Serbia). The study included patients over the age of 50 diagnosed with OA according to The European League Against Rheumatism (EULAR) criteria...
March 23, 2016: Acta Reumatológica Portuguesa
Wafa Haj Hamad, Marwa Maraoui, Mouna Sghir, Mohamed Guedria, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: The aim of our study was firstly to determine the frequency and the characteristics of metabolic syndrome in patients with knee osteoarthritis and secondly to assess the functional consequences of this combination. MATERIAL/PATIENTS AND METHODS: This is a prospective study including patients with knee OA referred to the department of physical medicine of Mahdia. In all patients, we sought the clinical and biological criteria for metabolic syndrome (according to NCEP - ATP III) and determined the radiological grade of knee OA according to Kellgren and Lawrence (KL)...
September 2016: Annals of Physical and Rehabilitation Medicine
Catherine Dziri, Ines Aloulou, Ines Loubiri, Meriem Rekik, Fatma Zohra Ben Salah, Anouer Abdallah
OBJECTIVE: Knee osteoarthritis is the most common site of osteoarthritis in Tunisia with a prevalence according to Tunisian League Anti-Rheumatic (LITAR) of 27.3%. The functional impact of knee osteoarthritis can cause major disability. The objective of this study is to identify priority disability of knee osteoarthritis by evaluating the Mactar index. MATERIAL/PATIENTS AND METHODS: Prospective descriptive study in the department of physical and rehabilitation medicine at Kassab Institute for six months with adult subjects suffering from knee pain associated with radiographically confirmed knee OA...
September 2016: Annals of Physical and Rehabilitation Medicine
C-D Liao, Y-C Huang, Y-S Chiu, T-H Liou
OBJECTIVE: Obesity may influence postoperative rehabilitation outcomes after total knee replacement (TKR). The aim of this study was to evaluate the effects of body mass index (BMI) on the progression of inpatient rehabilitation using continuous passive motion (CPM) and its treatment outcomes. PARTICIPANTS AND SETTING: A retrospective study was conducted in a rehabilitation centre. In total, 354 patients undergoing primary TKR were enrolled through medical chart review...
May 9, 2016: Physiotherapy
Fei Wang, Lei Shi, Qing-Yun Xue
BACKGROUND: The relationship between hand osteoarthritis (HOA) and systemic metabolic factors is unclear. The aim of this study was to investigate the prevalence of systemic metabolic factors including obesity, hypertension, diabetes mellitus, and atherosclerosis in symptomatic patients with HOA and the association between these systemic metabolic factors and symptomatic HOA in the Chinese Han population aged 40 years and above. METHODS: A cross-sectional survey was conducted on Chinese Han population aged 40 years and above in six centers in China...
2016: Chinese Medical Journal
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