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https://www.readbyqxmd.com/read/29035931/bioactive-lipids-in-osteoarthritis-risk-or-benefit
#1
Andreea Ioan-Facsinay, Margreet Kloppenburg
PURPOSE OF REVIEW: Lipids are bioactive molecules that can affect several biological functions. Technological developments allowing identification of novel lipid species and the study of their function have led to a significant advance in our understanding of lipid biology and their involvement in various diseases. This is particularly relevant for diseases associated with obesity in which lipid accumulation could be involved in pathogenesis. Here, we focus on osteoarthritis, a chronic joint disease aggravated by obesity, and will present the latest findings regarding the involvement of lipids in disease development and progression...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28975074/cooled-radiofrequency-ablation-of-genicular-nerves-for-knee-osteoarthritis-pain-a-protocol-for-patient-selection-and-case-series
#2
Rajiv D Reddy, Zachary L McCormick, Ben Marshall, Ryan Mattie, David R Walega
BACKGROUND: Chronic knee pain from osteoarthritis (OA) is common in the aging and the obese population. Radiofrequency ablation of the genicular nerves has been introduced as a potential surgery-sparing treatment for chronic knee pain from OA, yet only two outcome studies have been published and optimal patient selection for this procedure has not been established. OBJECTIVES: We describe a standardized protocol for selecting patients for cooled radiofrequency ablation (C-RFA) of the genicular nerves, as well as the clinical outcomes of four patients ages 63-65 years...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28973836/general-and-abdominal-obesity-as-risk-factors-for-late-life-mobility-limitation-after-total-knee-or-hip-replacement-for-osteoarthritis-among-women
#3
Aladdin H Shadyab, Wenjun Li, Charles B Eaton, Andrea Z LaCroix
OBJECTIVE: To investigate associations of body mass index (BMI), waist circumference (WC), and waist-hip ratio (WHR) with survival to age 85 with mobility limitation or death before age 85 among older women with total knee (TKR) or total hip (THR) replacement for osteoarthritis. METHODS: This was a prospective study of women (aged 65-79 years at baseline) from the Women's Health Initiative recruited during 1993-1998 and followed through 2012. Women's Health Initiative data were linked to Medicare claims data to determine TKR (n=1,867) and THR (n=944) for osteoarthritis...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28969948/the-effect-of-body-mass-index-on-clinical-outcomes-in-patients-without-radiographic-evidence-of-degenerative-joint-disease-after-arthroscopic-partial-meniscectomy
#4
Melissa A Kluczynski, John M Marzo, William M Wind, Marc S Fineberg, Geoffrey A Bernas, Michael A Rauh, Zehua Zhou, Jiwei Zhao, Leslie J Bisson
PURPOSE: To examine the effect of obesity on clinical outcomes at 1 year after arthroscopic partial meniscectomy. METHODS: We conducted a secondary analysis of the ChAMP (Chondral Lesions and Meniscus Procedures) randomized controlled trial (N = 256). The visual analog scale for pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), range of motion, and presence of effusion were assessed preoperatively and at 1 year after arthroscopic partial meniscectomy...
September 29, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28963268/can-osteoarthritis-predict-mortality
#5
Rebecca J Cleveland, Leigh F Callahan
Osteoarthritis is the most common musculoskeletal condition. Due to the aging population and rising obesity worldwide, the projected increase in osteoarthritis is expected to be substantial. Since osteoarthritis has been associated with disability and many chronic conditions such as obesity, diabetes, and cardiovascular disease, it is important to consider its impact on mortality.
September 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28957570/sarcopenic-obesity-is-more-prevalent-in-osteoarthritis-than-rheumatoid-arthritis-are-different-processes-involved
#6
Lara Vlietstra, Kim Meredith-Jones, Simon Stebbings, J Haxby Abbott, Gareth J Treharne, Debra L Waters
No abstract text is available yet for this article.
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28956662/leptin-alone-and-in-combination-with-interleukin-1-beta-induced-cartilage-degradation-potentially-inhibited-by-epa-and-dha
#7
Thanyaluck Phitak, Kanchanit Boonmaleerat, Peraphan Pothacharoen, Dumnoensun Pruksakorn, Prachya Kongtawelert
Osteoarthritis (OA) is the most common form of arthritis. Obesity has been believed to be an important risk factor for OA development and the progression of not only load-bearing joints, but low-load-bearing joints as well. Increased leptin has been the focus of a link between obesity and OA. In this study, the effects of pathological (100ng/ml) or supra-pathological (10μg/ml) concentrations of leptin alone or in combination with IL1β on cartilage metabolisms were studied in porcine cartilage explant. The involved mechanisms were examined in human articular chondrocytes (HACs)...
September 28, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28953085/efficacy-and-treatment-response-of-intra-articular-corticosteroid-injections-in-patients-with-symptomatic-knee-osteoarthritis
#8
Elizabeth G Matzkin, Emily J Curry, Qingwu Kong, Miranda J Rogers, Michael Henry, Eric L Smith
INTRODUCTION: Intra-articular corticosteroid injections are often used for short-term pain relief in patients with knee osteoarthritis (OA). This study investigates the efficacy of intra-articular corticosteroid injections in patients with symptomatic knee OA and factors that affect treatment response. METHODS: This prospective, multicentered cohort study had 100 participants with radiographic evidence of knee OA enrolled. Participants received one corticosteroid injection into the affected knee and were evaluated before the injection (baseline) and at 3 weeks, 6 weeks, 3 months, and 6 months after the injection...
October 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28941552/race-sex-and-risk-factors-in-radiographic-worsening-of-knee-osteoarthritis
#9
Ernest R Vina, Di Ran, Erin L Ashbeck, Charles Ratzlaff, C Kent Kwoh
OBJECTIVES: Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences. METHODS: Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN)...
August 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28940031/the-role-of-thermal-balneotherapy-in-the-treatment-of-obese-patient-with-knee-osteoarthritis
#10
Stefano Masiero, Filippo Vittadini, Costanza Ferroni, Anna Bosco, Roberto Serra, Anna Chiara Frigo, Antonio Frizziero
Osteoarthritis (OA) is the most common form of arthritis clinically characterized by joint pain, functional limitation, and reduced quality of life. Several studies have shown a clear link between obesity and higher risk of knee OA. According to the multifactorial OA pathogenesis, the management of this condition requires a multidisciplinary approach. The objective of this study is to evaluate hydrokinesitherapy effects in thermal setting in obese patients with knee OA. Fifty-three patients were assessed for eligibility, of which 33 refused the treatment, while 10 patients dropped out after the enrollment for personal reasons or inability to adhere to the program...
September 22, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28937501/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#11
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937470/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#12
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28916548/do-comorbidities-play-a-role-in-hand-osteoarthritis-disease-burden-data-from-the-hand-osteoarthritis-in-secondary-care-cohort
#13
Wendy Damman, Rani Liu, Féline P B Kroon, Monique Reijnierse, Tom W J Huizinga, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: Because the association and its clinical relevance between comorbidities and primary hand osteoarthritis (OA) disease burden is unclear, we studied this in patients with hand OA from our Hand OSTeoArthritis in Secondary care (HOSTAS) cohort. METHODS: Cross-sectional data from the HOSTAS study were used, including consecutive patients with primary hand OA. Nineteen comorbidities were assessed: 18 self-reported (modified Charlson index and osteoporosis) and obesity (body mass index ≥ 30 kg/m(2))...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28905144/knee-osteoarthritis-and-associated-cardio-metabolic-clusters-in-a-tertiary-hospital-in-nigeria
#14
Abubakar Yerima, Olufemi Adelowo
Osteoarthritis (OA) of the knee is the most common type of arthritis all over the world. Obesity is the strongest modifiable risk factor and causes OA through a combination metabolic factors and mechanical loading. This study aimed to determine the frequency of metabolic syndrome (Mets) among patients with knee OA and its relationship with pain and functional status. This was a descriptive hospital-based cross-sectional study involving patients with knee OA. Pain was measured using a 0-10 numeric rating visual analog scale (VAS)...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28899843/a-machine-learning-approach-for-the-identification-of-new-biomarkers-for-knee-osteoarthritis-development-in-overweight-and-obese-women
#15
N Lazzarini, J Runhaar, A C Bay-Jensen, C S Thudium, S M A Bierma-Zeinstra, Y Henrotin, J Bacardit
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low sensitivity. Therefore, there is a need for new biomarkers to correctly identify early knee OA. METHOD: We have created an analytics pipeline based on machine learning to identify small models (having few variables) that predict the 30-months incidence of knee OA (using multiple clinical and structural OA outcome measures) in overweight middle-aged women without knee OA at baseline...
September 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28892670/the-influence-of-sex-and-obesity-on-gait-biomechanics-in-people-with-severe-knee-osteoarthritis-scheduled-for-arthroplasty
#16
K L Paterson, L Sosdian, R S Hinman, T V Wrigley, J Kasza, M Dowsey, P Choong, K L Bennell
BACKGROUND: Sex and body mass may influence knee biomechanics associated with poor total knee arthroplasty (TKA) outcomes for knee osteoarthritis (OA). This study aimed to determine if gait differed between men and women, and overweight and class I obese patients with severe knee OA awaiting TKA. METHODS: 34 patients with severe knee OA (average age 70.0 (SD 7.2) years, body mass index 30.3 (4.1kg/m(2))) were recruited from a TKA waiting list. Three-dimensional gait analysis was performed at self-selected walking speed...
September 5, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28889010/pain-in-osteoarthritis-implications-for-optimal-management
#17
Anne-Priscille Trouvin, Serge Perrot
Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of people having OA pain, and creating a huge burden related to disability and health care costs. OA-related pain, has been classically considered to be a nociceptive pain condition. Clinicians have considered pain to be an alarm signal, correlated to the intensity of joint degradation...
September 6, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28872394/abdominal-circumference-versus-body-mass-index-as-predictors-of-lower-extremity-overuse-injury-risk
#18
Nathaniel S Nye, Drew S Kafer, Cara H Olsen, David H Carnahan, Paul F Crawford
BACKGROUND: Abdominal circumference (AC) is superior to body mass index (BMI) as a measure of risk for various health outcomes. Our objective was to compare AC and BMI as predictors of lower extremity overuse injury (LEOI) risk. METHODS: Retrospective review of electronic medical records of 79,868 United States Air Force personnel over a 7-year period (2005-2011) for incidence of new LEOI. Subjects were stratified by BMI and AC. Injury risk for BMI/AC subgroups was calculated using Kaplan-Meier curves and Cox proportional hazards regression...
September 5, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28861196/patellofemoral-joint-arthroplasty-early-results-and-functional-outcome-of-the-zimmer-gender-solutions-patello-femoral-joint-system
#19
Donald Osarumwense, Farhan Syed, Obi Nzeako, Segun Akilapa, Omer Zubair, Jon Waite
BACKGROUND: Improved knee prosthesis designs have led to an increase in the use of patellofemoral arthroplasty as a primary treatment option in recent times. We report the early results and outcomes of the Zimmer Gender Solutions Patello-Femoral Joint (PFJ) system used to treat isolated patellofemoral osteoarthritis (PFA). METHODS: We retrospectively reviewed and analysed data of patients who underwent PFJ replacement (PFJR) at our institution with a minimum follow-up of 2 years...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28860877/maintenance-of-the-paraspinal-muscles-may-protect-against-radiographic-knee-osteoarthritis
#20
Koichiro Azuma, Yasushi Sera, Takuma Shinjo, Michiyo Takayama, Eisuke Shiomi, Suketaka Momoshima, Yasushi Iwao, Hiroyuki Ishida, Hideo Matsumoto
BACKGROUND: Knee osteoarthritis (OA) is an increasing health problem worldwide. So far, only obesity and quadriceps weakness are identified as modifiable risk factors for knee OA. Core muscle strengthening is becoming increasingly popular among older adults because of its ability to enhance the activities of daily living during old age. This study investigated the associations of the size and quality of the abdominal trunk muscles with radiographic knee osteoarthritis (RKOA). METHODS: From 2012 to 2016, data were collected from 146 males and 135 females (age 63...
2017: Open Access Rheumatology: Research and Reviews
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