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osteoarthritis and obesity

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https://www.readbyqxmd.com/read/29691790/operation-change-a-new-paradigm-addressing-behavior-change-and-musculoskeletal-health-disparities
#1
Lynne C Jones, Yashika Watkins, Duanny Alva
BACKGROUND: In this study, we examined the implementation and efficacy of Operation Change, a community-based, culturally sensitive program to stimulate behavioral changes in activity level and improve musculoskeletal health in African-American (AA) and Hispanic/Latina (H/L) women with obesity and early-stage osteoarthritis. METHODS: Sixty-two women (32 AA and 30 H/L), 40-75 years old, with nontraumatic knee pain and body mass index values > 30, participated in a 12-week program of presentations, motivational interviewing, goal setting, and physical activities...
April 24, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#2
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29669931/targeting-the-gut-microbiome-to-treat-the-osteoarthritis-of-obesity
#3
Eric M Schott, Christopher W Farnsworth, Alex Grier, Jacquelyn A Lillis, Sarah Soniwala, Gregory H Dadourian, Richard D Bell, Madison L Doolittle, David A Villani, Hani Awad, John P Ketz, Fadia Kamal, Cheryl Ackert-Bicknell, John M Ashton, Steven R Gill, Robert A Mooney, Michael J Zuscik
Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel approach to treat the OA of obesity. Here, we report that - compared with the lean murine gut - obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29665829/effect-of-a-low-intensity-self-management-lifestyle-intervention-on-knee-pain-in-community-based-young-to-middle-aged-rural-women-a-cluster-randomised-controlled-trial
#4
Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R E Brady, Helena Teede, Flavia M Cicuttini
BACKGROUND: Knee pain is common with obesity and weight gain being important risk factors. Previous clinical trials have focused on overweight or obese adults with knee pain and osteoarthritis and demonstrated modest effects of intense weight loss programs on reducing knee pain despite very significant weight loss. There has been no lifestyle intervention that targets community-based adults to test its effect on prevention of knee pain. We aimed to determine the effect of a simple low-intensity self-management lifestyle intervention (HeLP-her), proven in randomised controlled trials to improve lifestyle and prevent weight gain, on knee pain in community-based young to middle-aged rural women...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29665085/carpal-tunnel-release-lifetime-prevalence-annual-incidence-and-risk-factors
#5
Mohammad-Hossein Pourmemari, Markku Heliövaara, Eira Viikari-Juntura, Rahman Shiri
INTRODUCTION: We estimated the lifetime prevalence and incidence of carpal tunnel release (CTR), and identified risk factors for CTR. METHODS: Study population consisted of individuals aged >30 years living in Finland during 2000-2001 (N=6256), and was linked to the Finnish Hospital Discharge Register from 2000 to 2011. RESULTS: Lifetime prevalence of CTR was 3.1% and incidence rate was 1.73 per 1000 person-years. Female sex (adjusted hazard ratio (HR)=1...
April 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29659687/obesity-interventions-for-older-adults-diet-as-a-determinant-of-physical-function
#6
Connie W Bales, Kathryn N Porter Starr
Throughout the world, a high prevalence of obesity in older populations has created a new phenotype of frailty: the obese, functionally frail older adult. The convergence of the obesity epidemic with global graying will undoubtedly increase the prevalence of this concern. Barriers to treatment include ambiguities about the appropriate level of obesity that should trigger an intervention, due to age-related physiologic changes and a lack of consensus on specific criteria and cutoffs. Moreover, obesity interventions for this population have been limited by concerns about negative effects on lean mass, bone mineral density, and even mortality...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#7
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29652820/diet-quality-and-nutrient-intake-of-urban-overweight-and-obese-primarily-african-american-older-adults-with-osteoarthritis
#8
Sevasti Vergis, Linda Schiffer, Tiffany White, Andrew McLeod, Neda Khudeira, Andrew Demott, Marian Fitzgibbon, Susan Hughes, Lisa Tussing-Humphreys
Diet quality may be a unique target for preventing and managing obesity-related osteoarthritis (OA). Using the Healthy Eating Index-2010 (HEI-2010), this study examined the nutrient intake and diet quality of 400 urban overweight and obese primarily African American older adults with self-reported lower extremity OA. Associations between sociodemographic and health-related factors and diet quality were explored. Participants (mean age 67.8 years, SD 5.9) were included. Habitual dietary intake was assessed using a food frequency questionnaire (FFQ)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29642931/bariatric-surgery-improves-knee-function-and-not-knee-pain-in-the-early-postoperative-period
#9
Amre Hamdi, Alia T Albaghdadi, Bayan Ghalimah, Abdullah Alnowiser, Anas Ahmad, Abdulmalik Altaf
BACKGROUND: Obesity remains the strongest predictor of knee osteoarthritis (OA). Studies have reported improvement in knee pain and function post-bariatric surgery secondary to weight loss and reduced mechanical loading, yet others found increased rates of total knee arthroplasty (TKA) in that patient population. To address this controversy, our study aimed to further assess the effect of surgically induced, "rapid" weight loss on knee pain and function. METHODS: Obese patients with chronic knee pain, who were undergoing bariatric surgery, were enrolled and surveyed preoperatively and 3 months postoperatively...
April 11, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29620639/the-role-of-leptin-in-osteoarthritis
#10
REVIEW
Moqi Yan, Junxin Zhang, Huilin Yang, Ye Sun
BACKGROUND: The pathogenesis of osteoarthritis (OA) is not clear; leptin may be related to its pathogenesis. METHODS: We reviewed articles on leptin in OA, chondrocytes, and in vitro experiments. It is concluded that leptin may lead to OA via some signaling pathways. At the same time, the concentration of leptin in vitro experiments and OA/rheumatoid arthritis (RA) patients was summarized. RESULTS: Leptin levels in serum and synovial fluid of OA/RA patients were higher than normal person...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619934/assessing-synovitis-with-conventional-static-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-knee-osteoarthritis
#11
Robert Gc Riis
Knee osteoarthritis (KOA) is one of the most common causes of physical disability in the elderly population. With an increasing ageing and obese population, the prevalence of KOA is expected to rise substantially. The needs for a better understanding of the disease and tools that can predict the course of the disease, for example following treatment, are therefore imperative. 

Inflammation has over the last years been recognised as an important factor for both the symptomatology and disease course in KOA...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619124/the-value-of-phenotypes-in-knee-osteoarthritis-research
#12
REVIEW
Fred R T Nelson
Background: Over the past decade, phenotypes have been used to help categorize knee osteoarthritis patients relative to being subject to disease, disease progression, and treatment response. A review of potential phenotype selection is now appropriate. The appeal of using phenotypes is that they most rely on simple physical examination, clinically routine imaging, and demographics. The purpose of this review is to describe the panoply of phenotypes that can be potentially used in osteoarthritis research...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29617634/surgical-weight-loss-to-improve-functional-status-trajectories-following-total-knee-arthroplasty-swift-trial-rationale-design-and-methods
#13
Peter N Benotti, Christopher D Still, G Craig Wood, Jamie L Seiler, Christopher J Seiler, Shane P Thomas, Anthony T Petrick, Michael Suk, Brian A Irving
Total Knee Arthroplasty (TKA, also known as total knee replacement) is a highly effective surgical intervention for the restoration of physical function and improving quality of life in patients with disabling knee osteoarthritis. Recent data suggest that obesity is a major risk factor in the pathogenesis and progression of knee osteoarthritis, with increases in body mass index (BMI, kg/m2 ) directly correlating with the prevalence of knee osteoarthritis. However, recent data also suggest that there are increased risks associated with TKAs when performed in patients with morbid obesity (BMI > 40 kg/m2 )...
April 1, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29613922/risk-reduction-compared-with-access-to-care-quantifying-the-trade-off-of-enforcing-a-body-mass-index-eligibility-criterion-for-joint-replacement
#14
Nicholas J Giori, Derek F Amanatullah, Shalini Gupta, Thomas Bowe, Alex H S Harris
BACKGROUND: Morbidly obese patients with severe osteoarthritis benefit from successful total joint arthroplasty. However, morbid obesity increases the risk of complications. Because of this, some surgeons enforce a body mass index (BMI) eligibility criterion above which total joint arthroplasty is denied. In this study, we investigate the trade-off between avoiding complications and restricting access to care when enforcing BMI-based eligibility criteria for total joint arthroplasty. METHODS: In this retrospective cohort study, the Veterans Health Administration (VHA) Corporate Data Warehouse (CDW) and Veterans Affairs Surgical Quality Improvement Program (VASQIP) databases were reviewed for patients undergoing total joint arthroplasty from October 2011 through September 2014...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29606151/fto-variant-is-not-associated-with-osteoarthritis-in-the-chinese-han-population-replication-study-for-a-genome-wide-association-study-identified-risk-loci
#15
Jin Dai, Pu Ying, Dongquan Shi, Huacheng Hou, Ye Sun, Zhihong Xu, Dongyang Chen, Guoqiang Zhang, Ming Ni, Huajian Teng, Yan Wang, Qing Jiang
BACKGROUND: Osteoarthritis is the most prevalent form of arthritis worldwide and is the major cause of pain and loss of function in elderly people. A signal of the fat mass and obesity-associated (FTO) gene had been reported in a genome-wide association study of osteoarthritis. The FTO polymorphism (rs8044769) might exert its effect on osteoarthritis through obesity, because it was reported as a body mass index-associated single-nucleotide polymorphism. And replication studies showed inconsistent results for this association...
April 2, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29602559/predictive-value-of-early-structural-changes-on-radiographs-and-mri-for-incident-clinical-and-radiographic-knee-osteoarthritis-in-overweight-and-obese-women
#16
Claudia Bernadette Maria Bijen, Jos Runhaar, Joanne Bernadine Marie Rijkels-Otters, Edwin Hong Gwan Oei, Sebastia Margaretha Agatha Bierma-Zeinstra
OBJECTIVE: To determine the predictive value of tibiofemoral (TF), patellofemoral (PF) MRI osteoarthritis (OA), and Kellgren and Lawrence grade 1 (KLG1) for the incidence of knee OA (clinical and/or radiological signs) at 2.5 and 6.5 years follow-up in a high-risk cohort. METHODS: Data of the PROOF study were used, consisting of middle-aged obese women without clinical (ACR-criteria) knee OA and free of radiographic signs (KLG < 2) at baseline. To determine the relation between MRI defined knee OA and KLG1 at baseline with clinical (ACR criteria) or radiographic OA (KLG ≥ 2) at the follow-up points, sensitivity, specificity, likelihood ratios and pre-test and post-test probabilities were calculated...
March 27, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29599843/platelet-rich-plasma-shows-beneficial-effects-for-patients-with-knee-osteoarthritis-by-suppressing-inflammatory-factors
#17
Guilin Huang, Sha Hua, Tuanmin Yang, Jianbing Ma, Wenxing Yu, Xiujin Chen
Knee osteoarthritis is a degenerative disease that may develop due ageing, obesity, strain, congenital abnormal joints, joint deformity or trauma. It is caused by many factors, such as degradation of articular cartilage injury, joint edge and subchondral bone hyperplasia of reactivity. Platelet-rich plasma (PRP) is an autologous blood sample that contains highly concentrated platelets and multiple cell growth factors. PRP promotes synovial cell proliferation and differentiation and may recover cartilage morphology...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29599027/predictors-of-the-effect-of-bariatric-surgery-on-knee-osteoarthritis-pain
#18
Shannon X Chen, Fernando A Bomfim, Heekoung A Youn, Christine Ren-Fielding, Jonathan Samuels
INTRODUCTION: Bariatric surgery reduces obesity and knee osteoarthritis (OA) pain, but some patients improve more than others. We aimed to identify characteristics that predict this knee pain improvement. METHODS: We reviewed NYU Langone Health bariatrics records (2002-2015) and called eligible patients reporting pre-operative knee pain. Patients were asked to rate their pain on a 10-point scale at three time points: before surgery, one year post-surgery, and time of survey administration...
February 8, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29594113/interplay-of-inflammatory-mediators-with-epigenetics-and-cartilage-modifications-in-osteoarthritis
#19
REVIEW
Swarna Raman, Una FitzGerald, J Mary Murphy
Osteoarthritis (OA), a degenerative disease of diarthrodial joints, is influenced by mechanical and inflammatory factors with aging, obesity, chronic injuries, and secondary diseases thought to be major factors driving the process of articular cartilage degeneration. Chondrocytes, the cellular component of cartilage, reside in an avascular environment and normally have limited potential to replicate. However, extrinsic factors such as injury to the joint or intrinsic alterations to the chondrocytes themselves can lead to an altered phenotype and development of OA...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29589988/laparoscopic-sleeve-gastrectomy-for-morbid-obesity-at-a-veterans-affairs-medical-center
#20
Matthew Skancke, Clint Schoolfield, Robert Grossman, Jennifer C Kerns, Nicole Abel, Fredrick Brody
BACKGROUND: Class III obesity is a global health emergency associated with an increase in the incidence of many other diseases such as type 2 diabetes mellitus, hypertension, hyperlipidemia, cancer, obstructive sleep apnea, nonalcoholic fatty liver disease, osteoarthritis, infertility, and mental health disorders. Minimal work has been published regarding the efficacy of laparoscopic sleeve gastrectomy (LSG) in the veteran population to surgically manage morbid obesity. DESIGN: Retrospective analysis of LSG performed at a Veterans Affairs Medical Center (VAMC) between 2010 and 2017...
March 28, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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