keyword
MENU ▼
Read by QxMD icon Read
search

osteoarthritis and obesity

keyword
https://www.readbyqxmd.com/read/28642544/resistin-promotes-the-abnormal-type-i-collagen-phenotype-of-subchondral-bone-in-obese-patients-with-end-stage-hip-osteoarthritis
#1
Ashleigh M Philp, Rebecca L Collier, Liam M Grover, Edward T Davis, Simon W Jones
The purpose of this study was to determine the effect of adiposity on the architecture and composition of hip OA subchondral bone, and to examine the pathological role of adipokines. Femoral heads were collected from normal-weight or over-weight/obese patients with hip OA. Structural parameters of subchondral bone were determined by MicroCT and type I collagen α1/α2 ratio was determined by SDS PAGE and by qRT-PCR in ex-vivo bone explants. The serum concentration of adipokines was determined by Luminex. The effect of resistin on primary OA osteoblasts was determined by analysis of Wnt pathway signal transduction, bone nodule formation, and osteoblast metabolic activity...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631699/-lower-extremity-venous-diseases-in-primary-knee-osteoarthritis
#2
O M Lesnyak, E V Zubareva, M G Goncharova, D M Maksimov
AIM: To establish a possible association between knee osteoarthritis (OA) and lower extremity venous diseases ((LEVDs) on the basis of thorough clinical and instrumental studies. SUBJECTS AND METHODS: A case-control study recruiting 40-60-year-old women was conducted. A study group included 85 women with knee OA; a control group consisted of 50 women without this condition. The patients of both groups underwent assessment of complaints and goal-directed objective examination to identify joint diseases and chronic LEVDs, knee X-ray study, and duplex scanning of the lower extremity veins...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28615667/il-6-secretion-in-osteoarthritis-patients-is-mediated-by-chondrocyte-synovial-fibroblast-cross-talk-and-is-enhanced-by-obesity
#3
Mark J Pearson, Dietmar Herndler-Brandstetter, Mohammad A Tariq, Thomas A Nicholson, Ashleigh M Philp, Hannah L Smith, Edward T Davis, Simon W Jones, Janet M Lord
Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. No differences in either peripheral blood or local lymphocyte populations were found between obese and normal-weight hip OA patients...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609388/can-dance-based-aquatic-exercise-improve-functionality-in-obese-women-with-knee-osteoarthritis
#4
Charrlotte Seib, Debra Anderson
No abstract text is available yet for this article.
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28606092/hyperlipidemic-microenvironment-conditionates-damage-mechanisms-in-human-chondrocytes-by-oxidative-stress
#5
Daniel Medina-Luna, Mónica Guadalupe Santamaría-Olmedo, Yessica Zamudio-Cuevas, Karina Martínez-Flores, Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, Denise Clavijo-Cornejo, Cristina Hernández-Díaz, Anell Olivos-Meza, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz, Carlos Pineda, Francisco Blanco, Anthony M Reginato, Alberto López-Reyes
BACKGROUND: Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this study was to evaluate the effect of free fatty acids (FFA) in human chondrocytes (HC) expression of proinflammatory factors and reactive oxygen species (ROS). METHODS: HC were exposed to two different concentrations of FFA in order to evaluate the secretion of adipokines through cytokines immunoassays panel, quantify the protein secretion of FFA-treated chondrocytes, and fluorescent cytometry assays were performed to evaluate the reactive oxygen species (ROS) production...
June 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28600365/effect-of-physical-activity-and-dietary-restriction-interventions-on-weight-loss-and-the-musculoskeletal-function-of-overweight-and-obese-older-adults-with-knee-osteoarthritis-a-systematic-review-and-mixed-method-data-synthesis
#6
Asma S Alrushud, Alison B Rushton, Archontissa M Kanavaki, Carolyn A Greig
BACKGROUND: Despite the clinical recommendation of exercise and diet for people with knee osteoarthritis (OA), there are no systematic reviews synthesising the effectiveness of combining physical activity and dietary restriction interventions on the musculoskeletal function of overweight and obese older adults with knee OA. OBJECTIVE: To evaluate the effectiveness of combined physical activity and dietary restriction programmes on body weight, body mass index (BMI) and the musculoskeletal function of overweight and obese older adults with knee OA...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28594499/medial-unicompartmental-knee-arthroplasty
#7
Andrew Barrister Richardson, Michael J Morris
Unicompartmental knee arthroplasty (UKA) has substantial benefits, including lower perioperative morbidity and earlier recovery, compared with total knee arthroplasty. The traditionally strict indications for UKA have been challenged by studies that expanded the indications based on a diagnosis of anteromedial osteoarthritis of the knee and demonstrated successful outcomes. The Nuffield criteria no longer prohibit patients from UKA based on age, obesity, anterior knee pain, or involvement of the patellofemoral joint...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28589161/arthroscopic-mechanical-chondroplasty-of-the-knee-is-beneficial-for-treatment-of-focal-cartilage-lesions-in-the-absence-of-concurrent-pathology
#8
Devon E Anderson, Michael B Rose, Aaron J Wille, Jack Wiedrick, Dennis C Crawford
BACKGROUND: Articular cartilage lacks the ability for intrinsic repair after acute injury, and focal articular cartilage lesions cause significant morbidity worldwide. Arthroscopic debridement (chondroplasty) represents the majority of cartilage procedures of the knee; however, limited data exist regarding outcomes after chondroplasty performed in isolation of concurrent procedures or not as a primary treatment for osteoarthritis (OA). HYPOTHESIS: Arthroscopic mechanical chondroplasty is beneficial for patients with a focal cartilage lesion of the knee in the absence of meniscal pathology or OA...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28573383/increased-expression-of-damage-associated-molecular-patterns-damps-in-osteoarthritis-of-human-knee-joint-compared-to-hip-joint
#9
John H Rosenberg, Vikrant Rai, Matthew F Dilisio, Todd D Sekundiak, Devendra K Agrawal
Osteoarthritis (OA) is a degenerative disease characterized by the destruction of cartilage. The greatest risk factors for the development of OA include age and obesity. Recent studies suggest the role of inflammation in the pathogenesis of OA. The two most common locations for OA to occur are in the knee and hip joints. The knee joint experiences more mechanical stress, cartilage degeneration, and inflammation than the hip joint. This could contribute to the increased incidence of OA in the knee joint. Damage-associated molecular patterns (DAMPs), including high-mobility group box-1, receptor for advanced glycation end products, and alarmins (S100A8 and S100A9), are released in the joint in response to stress-mediated chondrocyte and cartilage damage...
June 1, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28571180/gastroesophageal-reflux-disease-and-its-association-with-body-mass-index-clinical-and-endoscopic-study
#10
Bhumika Vaishnav, Arvind Bamanikar, Pragati Maske, Anudeep Reddy, Sukanya Dasgupta
INTRODUCTION: Obesity is rapidly becoming a pandemic and poses a serious health risk to the individuals. Abdominal obesity is quite common in India and is a prime risk factor for diseases like diabetes, coronary artery disease, Gastroesophageal Reflux Disease (GERD), osteoarthritis etc. A complex and multifactorial aetiopathogenesis of GERD exists in presence of obesity. The current study focuses on high Body Mass Index (BMI), a marker of obesity, as a risk factor for GERD and aims for a better understanding of their complex association...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28552637/variance-in-infra-patellar-fat-pad-volume-does-the-body-mass-index-matter-data-from-osteoarthritis-initiative-participants-without-symptoms-or-signs-of-knee-disease
#11
Birgit Burda, Eva Steidle-Kloc, Torben Dannhauer, Wolfgang Wirth, Anja Ruhdorfer, Felix Eckstein
The infra-patellar fat pad (IPFP) has been proposed to represent an endocrine link between obesity and knee osteoarthritis (OA). The purpose of the current study has been to explore the extent to which IPFP volume is related to body mass index (BMI). A total of 152 participants (age 56±7 years) without knee OA were studied. These consisted of 19 men and 19 women of normal weight (BMI 18.5-25), 19/19 pre-obese (BMI 25-30), 19/19 obese class I (BMI 30-35) and 19/19 obese class II (BMI 35-40), who were matched 1:1 for age and height...
May 25, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28545773/influence-of-body-mass-index-on-sagittal-knee-range-of-motion-and-gait-speed-recovery-1-year-after-total-knee-arthroplasty
#12
Alice Bonnefoy-Mazure, Pierre Martz, Stéphane Armand, Yoshimasa Sagawa, Domizio Suva, Katia Turcot, Hermes H Miozzari, Anne Lübbeke
BACKGROUND: The purpose of this prospective study was to investigate the influence of body mass index (BMI) on gait parameters preoperatively and 1 year after total knee arthroplasty (TKA). METHODS: Seventy-nine patients were evaluated before and 1 year after TKA using clinical gait analysis. The gait velocity, the knee range of motion (ROM) during gait, their gains (difference between baseline and 1 year after TKA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), quality of life, and patient satisfaction were assessed...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28544753/no-association-between-metabolic-syndrome-and-radiographic-hand-osteoarthritis-data-from-the-framingham-study
#13
Mette P Strand, Tuhina Neogi, Jingbo Niu, David T Felson, Ida K Haugen
OBJECTIVE: To explore whether metabolic syndrome (MetS) and its components are associated with hand OA using longitudinal data from the Framingham study. METHODS: In our cross-sectional analyses we included 1089 persons (age 50-75 years), of whom 785 had 7-year longitudinal radiographs. Of these, 586 with no hand OA at baseline were included in analyses on hand OA incidence. We explored associations between and MetS and its components (central obesity, hypertension, diabetes, triglyceridemia, low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with Kellgren-Lawrence grade≥2) using logistic regression analyses with adjustment for age, sex and body mass index (BMI)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544542/conditional-macrophage-depletion-increases-inflammation-and-does-not-inhibit-the-development-of-osteoarthritis-in-obese-mafia-mice
#14
Chia-Lung Wu, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, Farshid Guilak
OBJECTIVE: Macrophages are believed to play a critical role in the inflammation associated with the development of osteoarthritis (OA) in obesity. The objective of the study was to investigate whether short-term, systemic depletion of macrophages would mitigate OA following injury in obese mice. METHODS: CSF-1R-GFP(+) Macrophage Fas-Induced Apoptosis (MaFIA) transgenic mice that allow conditional depletion of macrophages were placed on a high-fat diet and underwent surgery to induce knee OA...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28540111/age-sex-body-mass-index-education-and-social-support-influence-functional-results-after-total-knee-arthroplasty
#15
Tomas Sveikata, Narunas Porvaneckas, Paulius Kanopa, Alma Molyte, Dalius Klimas, Valentinas Uvarovas, Algirdas Venalis
INTRODUCTION: Total knee arthroplasty (TKA) is an effective treatment for knee osteoarthritis. Patient-reported outcome after TKA is influenced by multiple patient-related factors. The aim of this study was to prospectively evaluate preoperative patient-related factors and to compare the self-reported outcomes 1 year after TKA among groups differing by age, sex, body mass index (BMI), education, and social support level. METHODS: 314 patients, who underwent TKA in Vilnius Republican University Hospital between the end of 2012 and the middle of 2014, were included in a study...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28539134/does-metformin-protect-against-osteoarthritis-an-electronic-health-record-cohort-study
#16
Lauren A Barnett, Kelvin P Jordan, John J Edwards, Danielle A van der Windt
BACKGROUND: Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes. OBJECTIVE: The aim is to investigate whether metformin reduces the risk of OA. METHODS: This was a cohort study set within the Consultations in Primary Care Archive, with 3217 patients with type 2 diabetes. Patients at 13 general practices with recorded type 2 diabetes in the baseline period (2002-2003) and no prior record of OA were identified...
May 25, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28535729/quantitative-genetics-of-circulating-hyaluronic-acid-ha-and-its-correlation-with-hand-osteoarthritis-and-obesity-related-phenotypes-in-a-community-based-sample
#17
Jai Prakash, Gulzhan Gabdulina, Svetlana Trofimov, Gregory Livshits
BACKGROUND: One of the potential molecular biomarkers of osteoarthritis (OA) is hyaluronic acid (HA). HA levels may be related to the severity and progression of OA. However, little is known about the contribution of major risk factors for osteoarthritis, e.g., obesity-related phenotypes and genetics to HA variation. AIM: To clarify the quantitative effect of these factors on HA. METHODS: An ethnically homogeneous sample of 911 apparently healthy European-derived individuals, assessed for radiographic hand osteoarthritis (RHOA), HA, leptin, adiponectin, and several anthropometrical measures of obesity-related phenotypes...
May 24, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28530520/cardiovascular-disease-and-gout-real-world-experience-evaluating-patient-characteristics-treatment-patterns-and-health-care-utilization
#18
Michael H Pillinger, Sripal Bangalore, Alyssa B Klein, Scott Baumgartner, Robert Morlock
BACKGROUND: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone. OBJECTIVE: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530065/-the-relationship-between-overweight-obesity-and-knee-osteoarthritis
#19
REVIEW
Tal Frenkel Rutenberg, Michael Drexler
The prevalence of overweight and obesity in the western world is growing, and with it there is a growing number of patients with osteoarthritis, a condition that leads to pain and disability. The association between body weight and osteoarthritis is mediated by both mechanical and humeral factors such as growth factors, hormones and mediators of the immune system. This review will present the mechanisms which lead to osteoarthritis, and will discuss available treatments which are suitable for the overweight and obese population, along with promising emerging new treatments...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28528004/potential-contributions-of-skeletal-muscle-contractile-dysfunction-to-altered-biomechanics-in-obesity
#20
REVIEW
Lance M Bollinger
Obesity alters whole body kinematics and joint kinetics during activities of daily living which are thought to contribute to increased risk of musculoskeletal injury, development of lower extremity joint osteoarthritis (OA), and physical disability. To date, it has widely been accepted that excess adipose tissue mass is the major driver of biomechanical alterations in obesity. However, it is well established that obesity is a systemic disease affecting numerous, if not all, organ systems of the body. Indeed, obesity elicits numerous adaptations within skeletal muscle, including alterations in muscle structure (ex...
July 2017: Gait & Posture
keyword
keyword
116006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"