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osteoarthritis and obesity

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https://www.readbyqxmd.com/read/28077692/reference-curves-for-the-australian-canadian-hand-osteoarthritis-index-in-the-middle-aged-dutch-population
#1
Féline P B Kroon, Sofia Ramiro, Patrick Royston, Saskia Le Cessie, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints. METHODS: Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45-65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1-5 vs >5)...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28072592/metabolic-syndrome-associated-osteoarthritis
#2
Alice Courties, Jérémie Sellam, Francis Berenbaum
PURPOSE OF REVIEW: Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings. RECENT FINDINGS: Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28065772/multimorbidity-in-middle-aged-adults-with-cerebral-palsy
#3
Nicole Cremer, Edward A Hurvitz, Mark D Peterson
BACKGROUND: Individuals with cerebral palsy have less lean body mass, greater relative adiposity, and lower fitness and physical activity participation; and yet, the prevalence of age-related multimorbidity in this population has yet to be established. PURPOSE: To examine the prevalence of lifestyle-related chronic conditions and multimorbidity in a sample of middle-aged adults with cerebral palsy. METHODS: A clinic-based sample of middle-aged adults with cerebral palsy was examined using Electronic Medical Records Search Engine (EMERSE) software...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28039964/degenerative-joint-diseases-and-neuroinflammation
#4
REVIEW
Mariella Fusco, Stephen D Skaper, Stefano Coaccioli, Antonella Paladini, Giustino Varrassi
Rheumatic and joint diseases, as exemplified by osteoarthritis and rheumatoid arthritis, are among the most widespread painful and disabling pathologies across the globe. Given the continuing rise in life expectancy, their prevalence is destined to grow. Osteoarthritis, a degenerative joint disease, is, in particular, on its way to becoming the fourth leading cause of disability worldwide by 2020, with the rising incidence of obesity in addition to age being important factors. It is estimated that 25% of osteoarthritic individuals are unable to perform daily activities...
December 31, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28013331/correlations-between-serum-adipocytokine-concentrations-disease-stage-radiological-status-and-total-body-fat-content-in-the-patients-with-primary-knee-osteoarthritis
#5
Magdalena Richter, Tomasz Trzeciak, Jakub Dalibor Rybka, Wiktoria Suchorska, Ewelina Augustyniak, Michał Lach, Małgorzata Kaczmarek, Jacek Kaczmarczyk
PURPOSE: The study was designed to investigate whether serum concentrations of leptin, resistin and adiponectin in obese and normal-weight patients with primary knee osteoarthritis (OA) correlate with clinical and radiological stages of the disease and percentage of total body fat. METHODS: Seventy-three patients with knee OA, divided into obese and normal-weight groups, were clinically evaluated according to the Knee Society Score (KSS), and radiologically assessed using Kellgren and Lawrence scale...
December 24, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/28011119/benefits-of-bariatric-surgery-before-elective-total-joint-arthroplasty-is-there-a-role-for-weight-loss-optimization
#6
Emanuel E Nearing, Tyler M Santos, Mark S Topolski, Andrew J Borgert, Kara J Kallies, Shanu N Kothari
BACKGROUND: The association between obesity and osteoarthritis is well established, as is the increased risk of postoperative complications after total knee arthroplasty (TKA) and total hip arthroplasty (THA) among patients with obesity. OBJECTIVE: To evaluate the outcomes after TKA/THA based on whether the surgery was performed before or after bariatric surgery. SETTING: Integrated, multispecialty, community teaching hospital. METHODS: The medical records of all patients who underwent bariatric surgery from 2001 to 2014 were reviewed...
November 9, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27994266/secretory-activity-of-subcutaneous-abdominal-adipose-tissue-in-male-patients-with-rheumatoid-arthritis-and-osteoarthritis-association-with-clinical-and-laboratory-data
#7
Ewa Kontny, Agnieszka Zielińska, Krystyna Księżopolska-Orłowska, Piotr Głuszko
INTRODUCTION: Adipose tissue exerts widespread effects on the metabolism and immune system, but its activity differs between the genders. In the general population low-grade adipose tissue inflammation contributes to development of diseases of affluence. Little is known about the systemic impact of peripheral fat tissue in osteoarthritis (OA) and rheumatoid arthritis (RA), characterized by chronic, low- and high-grade systemic inflammation, respectively. To clarify this we evaluated the secretory activity of subcutaneous abdominal adipose tissue (SAAT) obtained from male patients affected with RA (n = 21) and OA (n = 13), and assessed its association with body mass and composition, demographic, clinical and laboratory data...
2016: Reumatologia
https://www.readbyqxmd.com/read/27939623/factors-associated-with-meniscal-body-extrusion-on-knee-mri-in-overweight-and-obese-women
#8
F Zhang, S M Bierma-Zeinstra, E H G Oei, A Turkiewicz, M Englund, J Runhaar
OBJECTIVE: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). DESIGN: We used baseline data of the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study, Netherlands, comprising overweight or obese women aged 50-60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1...
December 7, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27927675/is-body-mass-index-associated-with-patellofemoral-pain-and-patellofemoral-osteoarthritis-a-systematic-review-and-meta-regression-and-analysis
#9
Harvi F Hart, Christian J Barton, Karim M Khan, Henrik Riel, Kay M Crossley
BACKGROUND: Patellofemoral pain (PFP) occurs frequently, and may be related to patellofemoral osteoarthritis (PFOA). Obesity is associated with increased risk of knee OA. This systematic review involves a meta-regression and analysis to determine the relationship between body mass index (BMI) and PFP and PFOA, and to determine the link between BMI and interventional outcomes. METHODS: We searched seven electronic databases and reference lists of relevant papers and systematic reviews, for cross-sectional, prospective, human-based observational and interventional studies reporting BMI in individuals with PFP or PFOA compared to healthy controls...
December 7, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27925193/systemic-and-local-adipose-tissue-in-knee-osteoarthritis
#10
REVIEW
Elisa Belluzzi, Hamza El Hadi, Marnie Granzotto, Marco Rossato, Roberta Ramonda, Veronica Macchi, Raffaele De Caro, Roberto Vettor, Marta Favero
Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the major joint affected. The symptoms of osteoarthritis include limited range of motion, joint swelling, and pain causing disability. There are no disease modifying drugs available, and treatments are mainly focused on pain management. Total knee replacement performed at the end stage of the disease is considered the only cure available. It has been found that obese people have an increased risk to develop not only knee but also hand osteoarthritis...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27919582/external-validation-of-a-prognostic-model-for-predicting-nonresponse-following-knee-arthroplasty
#11
Daniel L Riddle, Gregory J Golladay, William A Jiranek, Robert A Perera
BACKGROUND: Instruments designed to predict the extent of pain and function following knee arthroplasty (KA) recovery has strong potential to guide patients and clinicians in shared decision making. Our purpose was to test the external validity of a recently developed prognostic instrument designed to estimate the probability of nonresponse following KA. METHODS: We used data from the Osteoarthritis Initiative (OAI), a 9-year multisite National Institutes of Health study designed to examine the natural history of knee osteoarthritis in 4796 subjects...
November 15, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27917705/efficacy-of-argane-oil-on-metabolic-syndrome-in-a-moroccan-knee-osteoarthritis-population
#12
Jamila Essouiri, Fatima Ezzahra Abourazzak, Faiza Lazrak, Adil Najdi, Nadia Benaicha, Taoufik Harzy, Mourad Errasfa
Five medical conditions characterizes metabolic syndrome: abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoproteins cholesterol. When a patient has three of the five above parameters, he is called to have metabolic syndrome, and these conditions represents a key element in cardiovascular diseases. On the other hand, knee osteoarthritis is a degenerative disease which was shown to be affected by some of the parameters of metabolic syndrome...
December 4, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27908299/the-infrapatellar-fat-pad-induces-inflammatory-and-degradative-effects-in-articular-cells-but-not-through-leptin-or-adiponectin
#13
Jean-Baptiste Gross, Cecile Guillaume, Pascale Gegout-Pottie, Pascal Reboul, Jean-Yves Jouzeau, Didier Mainard, Nathalie Presle
OBJECTIVES: Based on a novel approach suggesting a role of adipose tissue in osteoarthritis (OA), we aimed to determine whether the infrapatellar fat pad (IFP) may affect joint cell functions through adipokines. METHODS: The conditioned media of IFP and subcutaneous adipose tissue from OA patients were used to determine the production of leptin and adiponectin, and to stimulate chondrocytes and fibroblast-like synoviocytes (FLS). Blocking experiments were carried out to evaluate the contribution of adipokines to IFP effects...
November 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27905906/discordance-between-self-reported-arthritis-and-musculoskeletal-signs-and-symptoms-in-older-women
#14
Tkt Lo, Lynne Parkinson, Michelle Cunich, Julie Byles
BACKGROUND: Arthritis is a gendered disease where women have a higher prevalence and more disability than men with arthritis of the same age. Health survey data is a major source of information for monitoring of the burden of arthritis. The validity of self-reported arthritis and the determinants of its accuracy among women have not been thoroughly studied. The objectives of this study were to: 1) examine the agreement between self-report diagnosed arthritis and musculoskeletal signs and symptoms in community-living older women; 2) estimate the sensitivity, specificity, and predictive values of self-reported arthritis; and 3) assess the factors associated with the disagreement...
December 1, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27895368/does-obesity-affects-early-infection-after-total-knee-arthroplasty-a-comparison-of-obese-vs-non-obese-patients
#15
Waseem Ahmed, Riaz Hussain Lakdawala, Yasir Mohib, Aurangzeb Qureshi, Rizwan Haroon Rashid
Surgical site infection (SSI) is a disastrous complication after total knee arthroplasty (TKA) which can cause prosthesis loosening and may end up in septicaemia. The incidence of infection reported to be in the range of 0.3-12.4% for primary TKA. Significantly higher infection rate is found in the morbidly obese patients. The current study compared the immediate rate of post-total knee replacement wound infection in the obese versus non-obese population. The cross-sectional study was conducted at Aga Khan University Hospital (AKUH) and comprised patients undergoing TKA for primary knee osteoarthritis...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27889689/osteoarthritis-and-type-2-diabetes-mellitus-what-are-the-links
#16
REVIEW
Alice Courties, Jérémie Sellam
Osteoarthritis (OA) is the most frequent joint disorder and one of the leading cause of disability. During a long time, it was considered as the consequence of aging and mechanical stress on cartilage. Recent advances in the knowledge of OA have highlighted that it is a whole joint disease with early modifications of synovium and subchondral bone but also that it is associated with obesity and metabolic syndrome through systemic mechanisms. In the past year, type 2 diabetes has been described in two meta-analyzes as an independent risk factor for OA...
December 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27884778/expression-of-adipokines-in-osteoarthritis-osteophytes-and-their-effect-on-osteoblasts
#17
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVE: Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with the pathogenesis of OA. Therefore, the effect of adipokines on bone and cartilage forming cells and osteophyte development was analyzed...
November 22, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27881997/relationship-of-anthropometric-measures-with-knee-osteoarthritis-in-diabetes-mellitus
#18
Saera Suhail Kidwai, Shaista Anwar Siddiqi, Lubna Nazir, Tahira Parveen Umer
OBJECTIVE: To determine the frequency of knee osteoarthritis in adult patients with Diabetes mellitus and its association with body mass index (BMI) in kg/m(2) and waist circumference (WC). METHODS: This is a cross-sectional comparative study at a tertiary hospital based in an industrial area of Karachi. Patient population comprised of all adult diabetic subjects. Clinical and demographic data was obtained with detailed musculoskeletal examination on all patients...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27865814/obesity-and-the-role-of-bariatric-surgery-in-the-surgical-management-of-osteoarthritis-of-the-hip-and-knee-a-review-of-the-literature
#19
REVIEW
Bryan D Springer, Jonathan T Carter, Alexander S McLawhorn, Keith Scharf, Mitchell Roslin, Kara J Kallies, John M Morton, Shanu N Kothari
Obesity accelerates the development of osteoarthritis of the knee and hip by exerting deleterious effects on joints through both biomechanical and also systemic inflammatory changes. The objective of this review was to evaluate the impact of obesity on lower limb biomechanics and total joint arthroplasty outcomes, as well as weight changes after joint arthroplasty and the role of bariatric surgery among patients requiring joint arthroplasty. The currently published data indicate that weight loss increases swing time, stride length, gait speed, and lower extremity range of motion...
September 14, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27861714/factors-influencing-transitions-between-frailty-states-in-elderly-adults-the-progetto-veneto-anziani-longitudinal-study
#20
Caterina Trevisan, Nicola Veronese, Stefania Maggi, Giovannella Baggio, Elena Debora Toffanello, Sabina Zambon, Leonardo Sartori, Estella Musacchio, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: To investigate frailty state transitions in a cohort of older Italian adults to identify factors exacerbating or improving frailty conditions. DESIGN: Population-based longitudinal study with mean follow-up of 4.4 years. SETTING: Community. PARTICIPANTS: Individuals enrolled in the Progetto Veneto Anziani (Pro.V.A.) (N = 2,925; n = 1,179 male, n = 1,746 female; mean age 74.4 ± 7.3). MEASUREMENTS: Frailty was identified at baseline and follow-up based on the presence of at least three Fried criteria; prefrailty was defined as the presence of one or two Fried criteria...
November 14, 2016: Journal of the American Geriatrics Society
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