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osteoarthritis and obesity

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https://www.readbyqxmd.com/read/28490838/adipokine-contribution-to-the-pathogenesis-of-osteoarthritis
#1
REVIEW
Daniel Azamar-Llamas, Gabriela Hernández-Molina, Bárbara Ramos-Ávalos, Janette Furuzawa-Carballeda
Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28484796/fusion-of-the-subtalar-joint-for-post-traumatic-arthrosis-a-study-of-functional-outcomes-and-non-unions
#2
Patrick Ziegler, Jan Friederichs, Sven Hungerer
BACKGROUND: The aim of this prospective cohort study was to quantify the rate of non-unions after arthrodesis of the subtalar joint, to identify risk factors and to evaluate the functional outcome. METHODS: Patients with subtalar fusion from 2000 to 2013 and pre-existing post-traumatic osteoarthritis of the subtalar joint were analysed for risk factors like revision surgery, infection history in the area of operation, obesity, diabetes, cigarette smoking and alcohol abuse...
May 8, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28478692/do-i-really-want-to-be-going-on-a-bloody-diet-gendered-narratives-in-older-men-with-painful-knee-osteoarthritis
#3
Francine Toye, Jonathan Room, Karen L Barker
PURPOSE: Small reductions in body weight can decrease osteoarthritic knee pain. Intuitively this should provide a strong incentive for weight-loss. However many people undergoing knee joint replacement (KJR) are categorised as obese. Gender theories can help us to understand differential responses to illness and therefore make an important contribution to rehabilitation. We aimed to explore barriers to weight loss in a group of older men with osteoarthritis. MATERIALS AND METHODS: We conducted 12 in-depth interviews, before and 1 year after surgery, with six obese men listed for KJR...
May 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28474284/damage-associated-molecular-patterns-in-the-pathogenesis-of-osteoarthritis-potentially-novel-therapeutic-targets
#4
REVIEW
John H Rosenberg, Vikrant Rai, Matthew F Dilisio, Devendra K Agrawal
Osteoarthritis (OA) is a chronic disease that degrades the joints and is often associated with increasing age and obesity. The two most common sites of OA in adults are the knee and hip joints. Increased mechanical stress on the joint from obesity can cause the articular cartilage to degrade and release damage-associated molecular patterns (DAMPs). These DAMPs are involved in various molecular pathways that interact with nuclear factor-kappa B and result in the transcription of inflammatory cytokines and activation of matrix metalloproteinases that progressively destroy cartilage...
May 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28470947/lifetime-risk-of-symptomatic-hand-osteoarthritis-the-johnston-county-osteoarthritis-project
#5
Jin Qin, Kamil E Barbour, Louise B Murphy, Amanda E Nelson, Todd A Schwartz, Charles G Helmick, Kelli D Allen, Jordan B Renner, Nancy A Baker, Joanne M Jordan
OBJECTIVE: Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors. METHODS: Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population-based prospective cohort study among residents of Johnston County, North Carolina...
May 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28463057/is-weight-loss-associated-with-less-progression-of-changes-in-knee-articular-cartilage-among-obese-and-overweight-patients-as-assessed-with-mr-imaging-over-48-months-data-from-the-osteoarthritis-initiative
#6
Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Gabby B Joseph, Nattagan Chanchek, Julio B Guimaraes, John Mbapte Wamba, Luca Facchetti, Charles E McCulloch, Thomas M Link
Purpose To investigate the association of weight loss with progression of cartilage changes at magnetic resonance (MR) imaging over 48 months in overweight and obese participants compared with participants of stable weight. Materials and Methods The institutional review boards of the four participating centers approved this HIPAA-compliant study. Included were (a) 640 participants (mean age, 62.9 years ± 9.1 [standard deviation]; 398 women) who were overweight or obese (body mass index cutpoints of 25 and 30 kg/m(2), respectively) from the Osteoarthritis Initiative, with risk factors for osteoarthritis or mild to moderate radiographic findings of osteoarthritis, categorized into groups with (a) weight loss of more than 10% (n = 82), (b) weight loss of 5%-10% (n = 238), or (c) stable weight (n = 320) over 48 months...
May 2, 2017: Radiology
https://www.readbyqxmd.com/read/28461646/how-are-obesity-and-body-composition-related-to-patellar-cartilage-a-systematic-review
#7
Sultana Monira Hussain, Mae Chyi Tan, Krista Stathakopoulos, Flavia M Cicuttini, Yuanyuan Wang, Louisa Chou, Donna M Urquhart, Anita E Wluka
OBJECTIVE: The aim of this review was to systematically examine the evidence for an association between measures of obesity [weight and body mass index (BMI)] and body composition (fat mass and fat-free mass) and patellar cartilage, assessed using magnetic resonance imaging. METHODS: Three electronic databases (MEDLINE, EMBASE, and CINAHL) were searched up to April 2016 using full text and MeSH terms to identify studies examining the associations between obesity and body composition, and patellar cartilage...
May 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28455181/discharge-to-inpatient-facilities-after-total-hip-arthroplasty-is-associated-with-increased-postdischarge-morbidity
#8
Michael C Fu, Andre M Samuel, Peter K Sculco, Catherine H MacLean, Douglas E Padgett, Alexander S McLawhorn
BACKGROUND: Discharge disposition accounts for significant variability in costs after elective total hip arthroplasty (THA). Therefore, institutions must evaluate the short-term clinical outcomes associated with postdischarge care options. The present study intends to characterize the associations between short-term morbidity after primary THA and discharge destination. METHODS: Primary elective unilateral THA cases performed for osteoarthritis were identified in the American College of Surgeons National Surgical Quality Improvement Program registry from 2011 to 2014...
March 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28429341/hyalone%C3%A2-in-the-treatment-of-symptomatic-hip-oa-data-from-the-antiage-register-seven-years-of-observation
#9
A Migliore, U Massafra, B Frediani, E Bizzi, E Sinelnikov Yzchaki, G Gigliucci, M Cassol, S Tormenta
OBJECTIVE: Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain. The aim of this study is to report the data of efficacy of US-guided HyalOne®/Hyalubrix® 60 injections in a large population of patients with hip osteoarthritis, repeated at least 2 times per year for up to seven years. PATIENTS AND METHODS: This is a prospective, post-marketing, cohort study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28425275/associations-between-obesity-and-the-radiographic-phenotype-in-knee-osteoarthritis
#10
Mehmet Derya Demirağ, Seçil Özkan, Şeminur Haznedaroğlu, Evin Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Göker
BACKGROUND/AIM: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. MATERIALS AND METHODS: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28419770/pilot-survey-of-the-health-of-massachusetts-dentists
#11
Romesh P Nalliah, Alan Budd, Veerasathpurush Allareddy
AIM: Dentistry is a career that is very rewarding because of the direct opportunity to deliver essential health services to patients in need. Dentistry is also very demanding; mentally, physically, and even emotionally. Little is known about the health of dentists and how it compares to the health of the general population. The aim of the present study was to report on the general health and health practices of dentists in Massachusetts. METHODS: A medical health and health practices survey was developed from the Delaware Valley Community Health Center and customized...
April 16, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28399156/presence-of-il-17-in-synovial-fluid-identifies-a-potential-inflammatory-osteoarthritic-phenotype
#12
Sarah J B Snelling, Sylvette Bas, Gabor J Puskas, Stephanie G Dakin, Domizio Suva, Axel Finckh, Cem Gabay, Pierre Hoffmeyer, Andrew J Carr, Anne Lübbeke
PURPOSE: Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28392856/impact-of-physical-activity-in-cardiovascular-and-musculoskeletal-health-can-motion-be-medicine
#13
REVIEW
Gannon L Curtis, Morad Chughtai, Anton Khlopas, Jared M Newman, Rafay Khan, Shervin Shaffiy, Ali Nadhim, Anil Bhave, Michael A Mont
Physical activity is a well-known therapeutic tool for various types of medical conditions, including vasculopathic diseases such as coronary artery disease, stroke, type 2 diabetes, and obesity. Additionally, increased physical activity has been proposed as a therapy to improve musculoskeletal health; however, there are conflicting reports about physical activity potentially leading to degenerative musculoskeletal disease, especially osteoarthritis (OA). Additionally, although physical activity is known to have its benefits, it is unclear as to what amount of physical activity is the most advantageous...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28390430/impact-of-the-body-mass-index-on-perioperative-immunological-disturbances-in-patients-with-hip-and-knee-arthroplasty
#14
Simon Jasinski-Bergner, Anna-Luise Radetzki, Janine Jahn, David Wohlrab, Heike Kielstein
BACKGROUND: Obesity increases the risk for knee and hip joint implantation and negatively contributes to wound healing. In this study, in 52 patients undergoing hip and knee arthroplasty the amount of peripheral immune effector cells pre- and post-operative, as well as the expression of certain soluble factors affecting the functions of immune effector cells were investigated. METHODS: The peripheral immune cells and the expression of the soluble factors were determined by flow cytometry and correlated to each other in dependency of the BMI, the sex, and the kind of arthroplasty...
April 8, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28374624/elevated-serum-leptin-levels-are-associated-with-low-vitamin-d-sarcopenic-obesity-poor-muscle-strength-and-physical-performance-in-knee-osteoarthritis
#15
Pacharee Manoy, Wilai Anomasiri, Pongsak Yuktanandana, Aree Tanavalee, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
CONTEXT: The associations between serum leptin, vitamin D status, sarcopenic obesity, muscle strength and physical performance in osteoarthritis (OA) remain uncertain. OBJECTIVE: To analyse the relationships between serum leptin, vitamin D status, muscle strength and physical performance in OA patients. METHODS: A total of 208 knee OA patients were enrolled. Serum leptin, vitamin D, muscle strength and physical performance were evaluated. RESULTS: OA patients with sarcopenic obesity had significantly higher serum leptin levels than those with non-sarcopenic obesity...
April 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28366049/does-obesity-influence-early-outcome-of-fixed-bearing-unicompartmental-knee-arthroplasty
#16
Yew Lok Woo, Yong Qiang Jerry Chen, Mun Chun Lai, Kheng Jin Darren Tay, Shi-Lu Chia, Ngai Nung Lo, Seng Jin Yeo
Obesity is a known major contributing risk factor for knee osteoarthritis (OA). It is also believed that obese unicompartmental knee arthroplasty (UKA) patients tend to have poorer outcome and possible early failure. The purpose of this study is to investigate the early outcome of obese UKA patients in a single institution. Patients who underwent fixed bearing medial UKA in between year 2005 and 2010 were included in this study. They were divided into four groups based on Body Mass Index (BMI): 25 kg/m(2) (Control); 25-29...
January 1, 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28355375/influence-of-morbid-obesity-on-physical-capacity-knee-related-symptoms-and-overall-quality-of-life-a-cross-sectional-study
#17
Lilian Sarli Tamura, Everton Cazzo, Elinton Adami Chaim, Sérgio Rocha Piedade
Objective: To evaluate the impact of morbid obesity on physical capacity, joint-related symptoms, and on the overall quality of life. Method: Cross-sectional study carried out at a university hospital, enrolling 39 individuals admitted to a bariatric surgery service. Physical capacity was assessed by Six-Minute Walk Test (SMWT) and the Borg rating of perceived exertion (RPE). Knee-related symptoms were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Lysholm Score...
February 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28351706/baseline-meniscal-extrusion-associated-with-incident-knee-osteoarthritis-after-30-months-in-overweight-and-obese-women
#18
J A van der Voet, J Runhaar, P van der Plas, D Vroegindeweij, E H Oei, S M A Bierma-Zeinstra
OBJECTIVE: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline. METHODS: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m(2)) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS)...
March 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28347438/corrigendum-to-obesity-is-associated-with-higher-absolute-tibiofemoral-contact-and-muscle-forces-during-gait-with-and-without-knee-osteoarthritis-clin-biomech-jan-31-2016-79-86
#19
G T Harding, M J Dunbar, C L Hubley-Kozey, W D Stanish, J L Astephen Wilson
No abstract text is available yet for this article.
March 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28336036/physical-function-and-physical-activity-in-obese-adults-after-total-knee-arthroplasty
#20
REVIEW
Webb A Smith, Audrey Zucker-Levin, William M Mihalko, Michael Williams, Mark Loftin, James G Gurney
Obese patients are more likely to have osteoarthritis and total knee arthroplasty (TKA). This investigation sought to evaluate physical function, activity level, and quality of life (QOL). Obese participants near 1-year postsurgical follow-up appointment were recruited. Evaluation included QOL and activity questionnaire, medical histories, anthropometrics, strength, and aerobic capacity. Sixty participants completed assessments. Obese TKA patients have physical performance limitations and low physical activity levels 1 year after surgery and completion of postoperative rehabilitation...
April 2017: Orthopedic Clinics of North America
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