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https://www.readbyqxmd.com/read/28823024/effect-of-kaempferia-parviflora-extract-on-knee-osteoarthritis
#1
Hiroko Kobayashi, Ryo Suzuki, Kei Sato, Takatoshi Ogami, Hiroshi Tomozawa, Masahito Tsubata, Koji Ichinose, Masaki Aburada, Wataru Ochiai, Kiyoshi Sugiyama, Tsutomu Shimada
Knee osteoarthritis (OA) is becoming more prevalent worldwide due to increases in the numbers of elderly and obese patients. Currently, pharmaceutical medicines used for the treatment of OA are for symptomatic therapy and therefore new therapeutic agents are needed. Kaempferia parviflora (KP) is a plant growing naturally in Southeast Asia and has various pharmacological effects including an anti-inflammatory effect, but no effect on OA has yet been reported. We therefore conducted a search for the effects KP and the active components of KP extract (KPE) exert on OA as well as its mechanism of action...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28821939/analgesic-use-in-patients-with-knee-and-or-hip-osteoarthritis-referred-to-an-outpatient-center-a-cross-sectional-study-within-the-amsterdam-osteoarthritis-cohort
#2
Jesper Knoop, Joyce van Tunen, Martin van der Esch, Leo D Roorda, Joost Dekker, Marike van der Leeden, Willem F Lems
Although analgesics are widely recommended in current guidelines, underuse and inadequate prescription of analgesics seem to result in suboptimal treatment effects in patients with knee and/or hip osteoarthritis (OA). This study aimed (i) to describe the use of analgesics; and (ii) to determine factors that are related to analgesic use in patients with knee and/or hip OA referred to an outpatient center. A cross-sectional study with data from 656 patients with knee and/or hip OA referred to an outpatient center (Amsterdam Osteoarthritis (AMS-OA) cohort) was conducted...
August 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28800775/lack-of-high-bmi-related-features-in-adipocytes-and-inflammatory-cells-in-the-infrapatellar-fat-pad-ifp
#3
Anja J de Jong, Inge R Klein-Wieringa, Stefan N Andersen, Joanneke C Kwekkeboom, Linda Herb-van Toorn, Badelog J E de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J L van der Heide, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch, Annemarie M Zuurmond, Vedrana Stojanovic-Susulic, Rob G H H Nelissen, René E M Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
BACKGROUND: Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and molecular body mass index (BMI)-related features in the IFP of OA patients. METHODS: Patients with knee OA (N = 155, 68% women, mean age 65 years, mean (SD) BMI 29...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28770095/demography-and-disorders-of-german-shepherd-dogs-under-primary-veterinary-care-in-the-uk
#4
Dan G O'Neill, Noel R Coulson, David B Church, Dave C Brodbelt
BACKGROUND: The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are now in decline in the UK. Accurate demographic and disorder data could assist with breeding and clinical prioritisation. The VetCompass(TM) Programme collects clinical data on dogs under primary veterinary care in the UK. This study included all VetCompass(TM) dogs under veterinary care during 2013...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28767924/elderly-with-knee-osteoarthritis-should-perform-nutritional-assessment-integrative-literature-review
#5
Isabelle Ferreira da Silva Souza, Rosa Sá de Oliveira Neta, Juliana Maria Gazzola, Marcelo Cardoso de Souza
To review scientific literature to assess nutritional status of elderly patients with osteoarthritis in the last 16 years. This is an integrative literature review that included articles published in national and international journals indexed in PubMed, SciELO and BIREME. We selected 14 articles, and English language was predominant. The year of publication of articles ranged from 2006 to 2016, and most of papers were cross-sectional studies. To gather papers and for posterior evaluate, we used a validated data collection instrument and the included studies were critical analyzed by reading, gathering and analysis of articles...
April 2017: Einstein
https://www.readbyqxmd.com/read/28765981/-anatomic-stabilization-of-chronic-lateral-instability-of-the-ankle-gold-technique
#6
REVIEW
T Diermeier, B Scheiderer, L Lacheta, A B Imhoff
OBJECTIVES: Anatomical reconstruction of the lateral ligament complex in the ankle. INDICATIONS: Chronic lateral ankle instability. CONTRAINDICATIONS: Severe osteoarthritis, obesity, hindfoot varus, general contraindications (infection, circulatory disorders, diabetic foot syndrome). SURGICAL TECHNIQUE: Anatomical V‑shaped reconstruction of the lateral ligament complex with half of the peroneus brevis tendon and additional retinaculum stabilization...
August 1, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28762210/association-between-the-severity-of-symptomatic-knee-osteoarthritis-and-cumulative-metabolic-factors
#7
Emi Yasuda, Ryuichi Nakamura, Ryo Matsugi, Shinsuke Goto, Yasunori Ikenaga, Kazunari Kuroda, Syunsuke Nakamura, Yasuo Katsuki, Tatsuo Katsuki
BACKGROUND: The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades. AIMS: To clarify the relationship between cumulative MS factors and symptomatic KOA. METHODS: A cross-sectional survey involving 119 women aged 45-88 years who were scheduled to undergo knee surgery was conducted. They were stratified into tertiles of symptoms as assessed by the Japanese Orthopedic Association score for KOA...
July 31, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28756278/effects-of-dietary-weight-loss-with-and-without-exercise-on-interstitial-matrix-turnover-and-tissue-inflammation-biomarkers-in-adults-with-knee-osteoarthritis-the-intensive-diet-and-exercise-for-arthritis-trial-idea
#8
R F Loeser, D P Beavers, A C Bay-Jensen, M A Karsdal, B J Nicklas, A Guermazi, D J Hunter, S P Messier
OBJECTIVE: To examine the effects of dietary weight loss, with and without exercise, on selected soluble biomarkers in overweight and obese older adults with symptomatic knee osteoarthritis (OA). DESIGN: Blood samples were analyzed from 429 participants in the Intensive Diet and Exercise for Arthritis (IDEA) trial randomized to either an 18 month exercise control group (E), weight loss diet (D), or D + E. C1M, C2M, C3M and CRPM biomarkers and interleukin-6 (IL-6) were quantitated using ELISAs...
July 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28747541/obesity-a-serious-etiologic-factor-for-male-subfertility-in-modern-society
#9
Yue Liu, Zhide Ding
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder resulting from behavioral, environmental and heritable causes. Such malfunction increases the risk of developing hypertension, diabetes, cardiovascular disease, respiratory problems, osteoarthritis and cancer. Meanwhile, the negative impact of obesity on male reproduction is gradually being recognized. According to clinical investigations and animal experiments, obesity is correlated with reductions in sperm concentration and motility, increases in sperm DNA damage and changes in reproductive hormonal levels...
July 26, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28747328/long-term-weight-loss-maintenance-in-obese-patients-with-knee-osteoarthritis-a-randomized-trial
#10
Pia Christensen, Marius Henriksen, Else M Bartels, Anthony R Leeds, Thomas Meinert Larsen, Henrik Gudbergsen, Birgit F Riecke, Arne Astrup, Berit L Heitmann, Mikael Boesen, Robin Christensen, Henning Bliddal
Background: A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear.Objective: We aimed to determine the effect of intermittent LED compared with daily meal replacements on weight-loss maintenance and number of knee replacements over 3 y.Design: The design was a randomized trial with participants aged >50 y who had knee osteoarthritis and a body mass index [BMI (in kg/m(2))] ≥30. Participants were recruited from the osteoarthritis outpatient clinic at Copenhagen University Hospital in Frederiksberg, Denmark; they had previously completed a 68-wk lifestyle intervention trial and achieved an average weight loss of 10...
July 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28734667/characterization-of-cartilage-defects-detected-by-mri-in-kellgren-lawrence-grade-0-or-1-knees
#11
Kenji Taguchi, Ko Chiba, Narihiro Okazaki, Yasuo Kido, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita, Masataka Uetani, Makoto Osaki
INTRODUCTION: Osteoarthritis of the knee is generally evaluated by plain X-rays, which are incapable of detecting small cartilage damage. There are some patients who have small cartilage defects on MRI with no abnormal findings on plain X-rays. In this study, the prevalence and regional characteristics of cartilage defects detected by MRI were studied in cases with normal X-ray findings (Kellgren-Lawrence grade 0 and 1). Relationships between the cartilage defects and OA risk factors such as obesity and leg alignment were also investigated...
July 19, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28724854/improvement-of-pulmonary-function-after-comprehensive-obesity-rehabilitation-program-in-obese-patients
#12
Tamao Takahashi, Satoru Ebihara, Masahiro Kohzuki
Obesity is a major risk factor of cardiovascular, osteoarthritis, metabolic and pulmonary disorders, and exercise is an efficient method for treating obesity. However, obese patients often complain of dyspnea on exertion, which makes it difficult to continue exercise program. Obesity is also known to have an adverse effect on pulmonary function. The purpose of this study was to examine the effects of a comprehensive obesity rehabilitation (COR) program on pulmonary function in Japanese patients with morbid obesity...
July 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28719557/functional-gain-and-pain-relief-after-total-joint-replacement-according-to-obesity-status
#13
Wenjun Li, David C Ayers, Courtland G Lewis, Thomas R Bowen, Jeroan J Allison, Patricia D Franklin
BACKGROUND: Obesity has been associated with lower function and more pain before and after total hip or knee replacement (THR or TKR). We examined the changes between preoperative and postoperative function and pain in a large representative U.S. cohort to determine if there was a relationship to obesity status. METHODS: Preoperative and 6-month postoperative data on function (Short Form-36 Physical Component Summary [PCS] score), joint pain (Hip disability and Osteoarthritis Outcome Score and Knee injury and Osteoarthritis Outcome Score), and body mass index (BMI) were collected from a national sample of 2,040 patients who had undergone THR and 2,964 who had undergone TKR from May 2011 to March 2013...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28718060/innate-immune-responses-and-osteoarthritis
#14
REVIEW
Evangelia Kalaitzoglou, Timothy M Griffin, Mary Beth Humphrey
PURPOSE OF THE REVIEW: Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory responses that contribute to OA progression and are the focus of this review. RECENT FINDINGS: Recent studies have identified risk factors for OA progression including increased innate immune responses secondary to aging-associated myeloid skewing, obesity-related myeloid activation, and synovial tissue hyperplasia with activated macrophage infiltration...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28711879/the-prevalence-incidence-and-progression-of-hand-osteoarthritis-in-relation-to-body-mass-index-smoking-and-alcohol-consumption
#15
Ida K Haugen, Karin Magnusson, Aleksandra Turkiewicz, Martin Englund
OBJECTIVE: To estimate the extent that overweight/obesity, smoking, and alcohol are associated with prevalence and longitudinal changes of radiographic hand osteoarthritis (OA). METHODS: Participants from the Osteoarthritis Initiative (n = 1232) were included, of whom 994 had 4-year followup data. In analyses on incident hand OA, only persons without hand OA at baseline were included (n = 406). Our exposure variables were overweight/obesity [body mass index (BMI), waist circumference], smoking (current/former, smoking pack-yrs), and alcohol consumption (drinks/week)...
July 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28710026/systematic-review-of-the-impact-of-osteoarthritis-on-health-outcomes-for-comorbid-disease-in-older-people
#16
REVIEW
L Parkinson, D L Waters, L Franck
OBJECTIVE: A systematic review was undertaken examining the impact of comorbid osteoarthritis on health outcomes for people aged 50 years or older with cardiovascular disease, diabetes or obesity. DESIGN: The protocol is registered in PROSPERO (CRD42015023417). Relevant electronic databases and grey literature were systematically searched for studies published in English between January 2005 and December 2016. Two reviewers independently screened studies for selection using predetermined inclusion and exclusion criteria, and independently completed methodological quality review...
July 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28696356/rapamycin-maintains-the-chondrocytic-phenotype-and-interferes-with-inflammatory-cytokine-induced-processes
#17
Andrea De Luna-Preitschopf, Hannes Zwickl, Stefan Nehrer, Markus Hengstschläger, Mario Mikula
Osteoarthritis (OA) is hallmarked by a progressive degradation of articular cartilage. Besides risk factors including trauma, obesity or genetic predisposition, inflammation has a major impact on the development of this chronic disease. During the course of inflammation, cytokines such as tumor necrosis factor-alpha(TNF-α) and interleukin (IL)-1β are secreted by activated chondrocytes as well as synovial cells and stimulate the production of other inflammatory cytokines and matrix degrading enzymes. The mTORC1 inhibitor rapamycin is a clinical approved immunosuppressant and several studies also verified its chondroprotective effects in OA...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28696168/point-of-no-return-for-improvement-of-cartilage-quality-indicated-by-dgemric-before-and-after-weight-loss-in-patients-with-knee-osteoarthritis-a-cohort-study
#18
Stine Hangaard, Henrik Gudbergsen, Marie Skougaard, Henning Bliddal, Janus D Nybing, Carl Johan Tiderius, Mikael Boesen
Background It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose To demonstrate a parallel change in cartilage morphology. Material and Methods Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28695973/what-is-the-impact-of-body-mass-index-on-cardiovascular-and-musculoskeletal-health
#19
Morad Chughtai, Anton Khlopas, Jared M Newman, Gannon L Curtis, Nipun Sodhi, Prem N Ramkumar, Rafay Khan, Shervin Shaffiy, Ali Nadhim, Anil Bhave, Michael A Mont
Obesity has become a major public health concern over the past several decades and has been shown to be associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, osteoarthritis (OA), and certain types of cancer. The impact of excess weight on cardiovascular and musculoskeletal health is not well-summarized in the literature, and there are some contradictory reports. Therefore, the purpose of this study was to assess the impact of body mass index (BMI) on: 1) cardiovascular outcomes; 2) osteoarthritis risk and progression; and 3) total knee arthroplasty outcomes (TKA)...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28695875/can-bariatric-surgery-delay-the-need-for-knee-replacement-in-morbidly-obese-osteoarthritis-patients
#20
Lajja Rishi, Mohit Bhandari, Ravindra Kumar
OBJECTIVE: The objective of the study was to find the weight reduction pattern and its outcome on knee pain and function in osteoarthritis (OA) morbidly obese patients' post-bariatric surgery with dietary and exercise changes. METHODOLOGY: Thirty morbidly obese (body mass index [BMI] >40 kg/m2) OA patients gave consent for bariatric surgery. Despite wearisome lifestyle modifications for weight loss and knee pain, satisfactory results were not retrieved. We took consent from all the patients predetermined for knee replacement in future because of pain and disability as recommended by knee replacement surgeon...
July 7, 2017: Journal of Minimal Access Surgery
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