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Gsk3 AND Pioglitazone

Nasim-Sadat Kajabadi, Ali Ghoochani, Maryam Peymani, Kamran Ghaedi, Abbas Kiani-Esfahani, Motahareh-Sadat Hashemi, Mohammad Hossein Nasr-Esfahani, Hossein Baharvand
Although human pluripotent stem cells (hPSCs) provide valuable sources for regenerative medicine, their applicability is dependent on obtaining both suitable up-scaled and cost effective cultures. The Rho-associated kinase (ROCK) inhibitor Y-27632 permits hPSC survival upon dissociation; however, cloning efficiency is often still low. Here we have shown that pioglitazone, a selective peroxisome proliferative-activated receptor-γ agonist, along with Y-27632 synergistically diminished dissociation-induced apoptosis and increased cloning efficiency (2-3-fold versus Y-27632) without affecting pluripotency of hPSCs...
October 23, 2015: Journal of Biological Chemistry
Teresa Ponce-Lopez, Gustavo Liy-Salmeron, Enrique Hong, Alfredo Meneses
Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinesterase (AChE) inhibitors, or improving glucose utilization drugs have reported a beneficial effect in ICV STZ-treated rats. In the present study the post-training administration of a glycogen synthase kinase (GSK3) inhibitor, lithium; antidementia drugs: phenserine and memantine, and insulin sensitizer, pioglitazone on memory function of ICV STZ-rats was assessed...
December 2, 2011: Brain Research
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