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Amit K. Verma

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https://www.readbyqxmd.com/read/28087116/application-of-whole-exome-sequencing-in-elucidating-the-phenotype-and-genotype-spectrum-of-junctional-epidermolysis-bullosa-a-preliminary-experience-of-a-tertiary-care-centre-in-india
#1
Vamsi K Yenamandra, Shamsudheen K Vellarikkal, Manoj Kumar, Madhumita R Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata B Ray, Amit K Dinda, Madhulika Kabra, Punit Kaur, Vinod K Sharma, Gomathy Sethuraman
BACKGROUND: Junctional epidermolysis bullosa (JEB) is a diverse group of genodermatoses associated with extreme skin fragility. Despite several well-characterized genetic studies, molecular diagnosis of this heterogeneous group is still challenging. Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing (WES) as a fast and efficient diagnostic strategy in several genodermatoses. OBJECTIVE: In view of the scarcity and need of molecular studies for JEB in India, we sought to explore the potential of WES in understanding the mutational spectrum of this rare, in certain subtypes lethal, sub-group of EB...
December 29, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28031539/recurrent-genetic-defects-on-chromosome-5q-in-myeloid-neoplasms
#2
Naoko Hosono, Hideki Makishima, Reda Mahfouz, Bartlomiej Przychodzen, Kenichi Yoshida, Andres Jerez, Thomas LaFramboise, Chantana Polprasert, Michael J Clemente, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Masashi Sanada, Edward Cui, Amit K Verma, Michael A McDevitt, Alan F List, Yogen Saunthararajah, Mikkael A Sekeres, Jacqueline Boultwood, Seishi Ogawa, Jaroslaw P Maciejewski
BACKGROUND: Deletion of chromosome 5q (del(5q)) is the most common karyotypic abnormality in myeloid neoplasms. MATERIALS AND METHODS: To define the pathogenic molecular features associated with del(5q), next-generation sequencing was applied to 133 patients with myeloid neoplasms (MDS; N = 69, MDS/MPN; N = 5, sAML; N = 29, pAML; N = 30) with del(5q) as a sole abnormally or a part of complex karyotype and results were compared to molecular features of patients diploid for chr5...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28018062/non-union-fracture-neck-femur-in-a-toddler-reconstructed-by-valgus-osteotomy-a-minimally-invasive-approach
#3
Amit Sharma, Anurag Tiwari, Tarun Verma, Lalit Maini
BACKGROUND: Non-union is one of the devastating complications of fracture neck of femur. Though a very rarely encountered entity in a toddler (1-3 years paediatric age group), non-united femoral neck fractures are reported in developing countries because of mismanagement by quacks and delay in referrals. For operative treatment, many different procedures have been described, including close/open reduction and internal fixation using K-wires, cannulated screws, fibula or nails. There is no evidence in the literature that one or other implant influences the rate of postoperative complications, such as avascular femoral head necrosis or coxa vara...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27847209/in-vivo-study-for-anti-hyperglycemic-potential-of-aqueous-extract-of-basil-seeds-ocimum-basilicum-linn-and-its-influence-on-biochemical-parameters-serum-electrolytes-and-haematological-indices
#4
Sachin Chaudhary, Amit Semwal, Hitesh Kumar, Harish Chandra Verma, Amit Kumar
The study introduced anti-hyperglycemic influence of aqueous extract of Ocimum basilicum seeds (AEOBS) in Streptozotocin (STZ) induced diabetic rats and estimating its potential to ameliorate altered level of biochemical parameters, serum electrolytes level and haematological indices along with its effect on body weight of treated rats. The albino rats were selected to observe oral glucose tolerance test by oral intake of aq. glucose solution (4g/kg, body weight) in normal rats and estimation of blood glucose level after administration of AEOBS at 250mg/kg, 500mg/kg and standard drug glibenclamide at 0...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27753658/immunohistochemical-expression-of-antitissue-transglutaminase-2-in-tissue-injuries-an-interpretation-beyond-celiac-disease
#5
Prasenjit Das, Ramakant Rawat, Anil K Verma, Geetika Singh, Archana G Vallonthaiel, Rajni Yadav, Gaurav P S Gahlot, Amit K Dinda, Vineet Ahuja, Siddhartha Datta Gupta, Sanjay K Agarwal, Govind K Makharia
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27651574/a-retrospective-case-control-study-evaluating-the-role-of-mifepristone-for-induction-of-labor-in-women-with-previous-cesarean-section
#6
Chanderdeep Sharma, Anjali Soni, Pawan K Soni, Suresh Verma, Ashok Verma, Amit Gupta
OBJECTIVE: To investigate the role of "mifepristone" for induction of labor (IOL) in pregnant women with prior cesarean section (CS). METHODS: In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27542713/dihydroxyselenolane-dhs-supplementation-improves-survival-following-whole-body-irradiation-wbi-by-suppressing-tissue-specific-inflammatory-responses
#7
Amit Kunwar, Prachi Verma, H N Bhilwade, Michio Iwaoka, K Indira Priyadarsini
Dihydroxyselenolane (DHS), a simple water-soluble organoselenium compound, was evaluated for radioprotection in BALB/c mice after whole-body irradiation (WBI) (8Gy (60)Co, 1Gy/min), by monitoring 30-d post-irradiation survival and biochemical/histological changes in radiosensitive organs. Intraperitoneal administration of DHS at 2mg/kg for five consecutive days before irradiation and three times per week during the post-irradiation period showed maximum benefit (40% improvement in 30 d post-irradiation survival)...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27530498/prospective-evaluation-of-intra-operative-quick-parathyroid-hormone-assay-as-an-early-predictor-of-post-thyroidectomy-hypocalcaemia
#8
Ashwini C Reddy, Gyan Chand, M Sabaretnam, Anjali Mishra, Gaurav Agarwal, Amit Agarwal, A K Verma, S K Mishra
BACKGROUND: Hypocalcaemia following total thyroidectomy is a major contributing factor in delayed hospital discharge and dissuading surgeons from day care thyroidectomy. We prospectively evaluated the utility of Intra-operative serum quick parathyroid hormone level measurement twenty minutes after total thyroidectomy in predicting post-operative hypocalcemia. MATERIAL AND METHODS: Prospective longitudinal study which included patients undergoing total thyroidectomy for benign or malignant thyroid disorders at SGPGIMS, Lucknow, India from November 2013 to February 2015...
October 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27493460/indian-national-association-for-study-of-the-liver-inasl-guidance-for-antiviral-therapy-against-hcv-infection-update-2016
#9
REVIEW
Pankaj Puri, Vivek A Saraswat, Radha K Dhiman, Anil C Anand, Subrat K Acharya, Shivaram P Singh, Yogesh K Chawla, Deepak N Amarapurkar, Ajay Kumar, Anil Arora, Vinod K Dixit, Abraham Koshy, Ajit Sood, Ajay Duseja, Dharmesh Kapoor, Kaushal Madan, Anshu Srivastava, Ashish Kumar, Manav Wadhawan, Amit Goel, Abhai Verma, Shalimar, Gaurav Pandey, Rohan Malik, Swastik Agrawal
India contributes significantly to the global burden of HCV. While the nucleoside NS5B inhibitor sofosbuvir became available in the Indian market in March 2015, the other directly acting agents (DAAs), Ledipasvir and Daclatasvir, have only recently become available in the India. The introduction of these DAA in India at a relatively affordable price has led to great optimism about prospects of cure for these patients as not only will they provide higher efficacy, but combination DAAs as all-oral regimen will result in lower side effects than were seen with pegylated interferon alfa and ribavirin therapy...
June 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27479769/endoscopic-combined-intrarenal-surgery-for-simultaneous-renal-and-ureteral-stones-a-retrospective-study
#10
Ramanitharan Manikandan, Jayesh Kumar Mittal, Lalgudi Narayanan Dorairajan, Amit Kumar Mishra, Kodakkatil Sreenivasan Sreerag, Anil Verma
PURPOSE: The management of simultaneous renal and ureteral calculi usually require staged procedure or change of position from supine lithotomy for ureterorenoscopic lithotripsy to prone for conventional percutaneous nephrolithotomy (PCNL). We review our experience with endoscopic combined intrarenal surgery (ECIRS) in the management of this condition. MATERIALS AND METHODS: A total of 43 patients with simultaneous renal and ureteral calculi underwent ECIRS in Galdakao-modified supine Valdivia (GMSV) position from June 2012 to March 2016...
October 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27468288/phenotypic-and-marker-assisted-genetic-enhancement-of-parental-lines-of-rajalaxmi-an-elite-rice-hybrid
#11
Amit K Dash, Ravi N Rao, G J N Rao, Ram L Verma, Jawahar L Katara, Arup K Mukherjee, Onkar N Singh, Torit B Bagchi
The cytoplasmic male sterile line system comprising CRMS 32A and its maintainer line CRMS 32B is a popular choice for the development of new hybrids in India as CRMS 32A, having Kalinga 1 cytoplasm (other than WA), is a viable alternative to WA cytoplasm. However, both lines are susceptible to bacterial blight (BB), a major disease on rice. As enhancement of host plant resistance is the most effective and economical strategy to control this disease, four resistance genes (Xa4, xa5, xa13, and Xa21) were transferred from a BB pyramid line of IR64, into the A and B lines using a marker-assisted backcrossing (MAB) breeding strategy...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27356050/progenitor-cell-mobilization-by-gamma-tocotrienol-a-promising-radiation-countermeasure
#12
Vijay K Singh, Oluseyi O Fatanmi, Amit Verma, Victoria L Newman, Stephen Y Wise, Patricia L P Romaine, Allison N Berg
This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). GT3 protects mice against high doses of ionizing radiation and induces high levels of granulocyte colony-stimulating factor (G-CSF). GT3-induced G-CSF in conjunction with AMD3100 (a chemokine receptor antagonist clinically used to improve the yield of mobilized progenitors) mobilizes progenitors; these mobilized progenitors mitigate injury when infused to mice exposed to acute, high-dose ionizing radiation...
August 2016: Health Physics
https://www.readbyqxmd.com/read/27291252/microbial-keratinases-industrial-enzymes-with-waste-management-potential
#13
Amit Verma, Hukum Singh, Shahbaz Anwar, Anirudha Chattopadhyay, Kapil K Tiwari, Surinder Kaur, Gurpreet Singh Dhilon
Proteases are ubiquitous enzymes that occur in various biological systems ranging from microorganisms to higher organisms. Microbial proteases are largely utilized in various established industrial processes. Despite their numerous industrial applications, they are not efficient in hydrolysis of recalcitrant, protein-rich keratinous wastes which result in environmental pollution and health hazards. This paved the way for the search of keratinolytic microorganisms having the ability to hydrolyze "hard to degrade" keratinous wastes...
June 13, 2016: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/27144332/analysis-of-overall-survival-in-a-large-multiethnic-cohort-reveals-absolute-neutrophil-count-of-1-100-as-a-novel-prognostic-cutoff-in-african-americans
#14
Ioannis Mantzaris, Yiting Yu, Pavlos Msaouel, Anthony P Lam, Murali Janakiram, Ellen W Friedman, Ulrich Steidl, Amit K Verma
Although absolute neutrophil counts (ANC) below 1.5x103/uL are used to define neutropenia as a marker of increased susceptibility to infections, their relationship with survival has not been examined. Since low counts trigger extensive investigations, determining prognostic cutoffs especially for different ethnicities and races is critical.A multiethnic cohort of 27,760 subjects, 65 years old and above, was utilized to evaluate the association of neutropenia with overall survival in different ethnicities and races...
18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27076671/association-of-hemoglobin-concentration-with-total-and-cause-specific-mortality-in-a-cohort-of-postmenopausal-women
#15
Geoffrey C Kabat, Mimi Y Kim, Amit K Verma, JoAnn E Manson, Lawrence S Lessin, Victor Kamensky, Juan Lin, Sylvia Wassertheil-Smoller, Thomas E Rohan
Anemia and low and high levels of hemoglobin have been associated with increased mortality and morbidity. However, most studies have measured hemoglobin at only 1 time point, and few studies have considered possible reverse causation. We used data from the Women's Health Initiative, in which baseline hemoglobin was measured in 160,081 postmenopausal women and year 3 hemoglobin was measured in 75,658 participants, to examine the associations of hemoglobin concentration with total mortality, coronary heart disease mortality, and cancer mortality...
May 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27014452/systemic-mastocytosis-presenting-as-cardiac-tamponade-with-cd25-pericardial-mast-cells
#16
Vineeth K Sukrithan, Jason N Salamon, Giorgi Berulava, Nicholas E Sibinga, Amit Verma
In this first-in-literature case, we describe a patient with Systemic mastocytosis presenting with life-threatening cardiac tamponade associated with the presence of aberrant mast cells in the pericardium. Procedures involving surgical incisions through the pericardium in such cases can lead to uncontrolled mast cell degranulation leading to circulatory collapse.
March 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/26762603/identification-of-internal-control-genes-in-milk-derived-mammary-epithelial-cells-during-lactation-cycle-of-indian-zebu-cow
#17
Pradeep Jatav, Monika Sodhi, Ankita Sharma, Sandeep Mann, Amit Kishore, Umesh K Shandilya, Ashok K Mohanty, Ranjit S Kataria, Poonam Yadav, Preeti Verma, Surinder Kumar, Dhruba Malakar, Manishi Mukesh
The present study aims to evaluate the suitability of 10 candidate genes, namely GAPDH, ACTB, RPS15A, RPL4, RPS9, RPS23, HMBS, HPRT1, EEF1A1 and UBI as internal control genes (ICG) to normalize the transcriptional data of mammary epithelial cells (MEC) in Indian cows. A total of 52 MEC samples were isolated from milk of Sahiwal cows (major indigenous dairy breed of India) across different stages of lactation: Early (5-15 days), Peak (30-60 days), Mid (100-140 days) and Late (> 240 days). Three different statistical algorithms: geNorm, Normfinder and BestKeeper were used to assess the suitability of these genes...
March 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/26612120/masterly-inactivity-in-infantile-haemangioma-does-it-still-hold-relevance
#18
Nitin Sharma, Minu Bajpai, Ajay Verma, Shasanka Shekhar Panda, Amit K Singh
BACKGROUND: Haemangiomas are a source of concern to the parents. It has long been advised to plan a conservative management and counsel the attendants in various literatures owing to the spontaneous regression in these cases. We tried to find out the role of conservative management in our setup. The objective of this study was to assess the effect of conservative management in infantile haemangiomas. MATERIALS AND METHODS: This was a retrospective study from January 2001 to December 2012 including infants with haemangioma in low risk locations...
July 2015: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/26585386/polyketide-quinones-are-alternate-intermediate-electron-carriers-during-mycobacterial-respiration-in-oxygen-deficient-niches
#19
Amitesh Anand, Priyanka Verma, Anil Kumar Singh, Sandeep Kaushik, Rajesh Pandey, Ce Shi, Harneet Kaur, Manbeena Chawla, Chandra Kumar Elechalawar, Dhirendra Kumar, Yong Yang, Neel S Bhavesh, Rajkumar Banerjee, Debasis Dash, Amit Singh, Vivek T Natarajan, Anil K Ojha, Courtney C Aldrich, Rajesh S Gokhale
Mycobacterium tuberculosis (Mtb) adaptation to hypoxia is considered crucial to its prolonged latent persistence in humans. Mtb lesions are known to contain physiologically heterogeneous microenvironments that bring about differential responses from bacteria. Here we exploit metabolic variability within biofilm cells to identify alternate respiratory polyketide quinones (PkQs) from both Mycobacterium smegmatis (Msmeg) and Mtb. PkQs are specifically expressed in biofilms and other oxygen-deficient niches to maintain cellular bioenergetics...
November 19, 2015: Molecular Cell
https://www.readbyqxmd.com/read/26492324/application-of-spectrum-shifting-methodology-to-restore-nai-tl-recorded-gamma-spectra-shifted-due-to-temperature-variations-in-the-environment
#20
Pratip Mitra, Arup Singha Roy, Amit K Verma, Amar D Pant, M S Prakasha, S Anilkumar, A Vinod Kumar
A method has been standardized for restoring a shifted differential pulse height spectrum from a scintillator based gamma ray spectrometer recorded at measurement temperature, to the position of a desired spectrum, recorded at a reference temperature. The method is based on the assumption that the spectrum obtained at measurement temperature represents the same statistical distribution as that at reference temperature but with different energy scales. A computer program has been developed for calculation of the transformation between the energy scales and for the restoration of the shifted spectrum...
January 2016: Applied Radiation and Isotopes
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