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Amit K. Verma

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https://www.readbyqxmd.com/read/29775225/cytokines-and-chemokines-differentially-regulate-innate-immune-cell-trafficking-during-post-kala-azar-dermal-leishmaniasis
#1
Ashish K Singh, Vidya N R Das, Ajay Amit, Manas R Dikhit, Vijaya Mahantesh, Shubhankar K Singh, Shyam Naryan, Krishna Pandey, Pradeep Das, Neena Verma, Sanjiva Bimal
Post kala-azar dermal leishmaniasis (PKDL) is often considered to be the anthroponotic reservoir of visceral leishmaniasis (VL) in India. A better understanding of the host immune-response in dermal lesions of PKDL patients is therefore of utmost significance to minimize such patients and to restrict VL transmission. Although the innate immune response is known to play an important role in parasite clearance from dermal lesions, the actual contribution of innate cells to the pathogenicity of PKDL is poorly understood...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29599340/myelodysplastic-syndrome-and-sweet-s-syndrome-are-associated-with-a-mutation-in-isocitrate-dehydrogenase-1
#2
Rose Snyder, Tiffany Libby, Patricia Raciti, Bijal Amin, Mark Jacobson, Dinesh Rakheja, Kirsten Fleming, Matthias Bartenstein, Changcheng Zhu, Swati Goel, Amit K Verma, Aditi Shastri
BACKGROUND: Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29504866/diagnostic-challenges-of-adult-t-cell-leukemia-lymphoma-in-north-america-a-clinical-histological-and-immunophenotypic-correlation-with-a-workflow-proposal
#3
Michael J Licata, Murali Janakiram, Stephanie Tan, Yanan Fang, Urvi A Shah, Amit K Verma, Yanhua Wang
Adult T-cell leukemia-lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1) and little is known about ATLL endemic to the Caribbean basin and Latin America, designated as western ATLL (W-ATLL). Due to extensive systemic involvement and nonspecific clinical presentation, the initial diagnosis in this cohort can be very challenging. We have diagnosed 60 patients with W-ATLL over a 14-year period. ATLL involves the peripheral blood, bone marrow, and cerebrospinal fluid (CSF) in 98, 87, and 52% cases, respectively; while lymphadenopathy, pulmonary infiltrates, splenomegaly, and hepatomegaly was present in 90, 82, 48, and 45% patients, respectively...
May 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29486969/design-and-synthesis-of-1-4-substituted-1h-1-2-3-triazolo-quinazolin-4-3h-ones-by-huisgen-1-3-dipolar-cycloaddition-with-pi3k%C3%AE-isoform-selective-activity
#4
M Srinivas, Anup Singh Pathania, Priya Mahajan, Praveen K Verma, Santosh S Chobe, Fayaz A Malik, Amit Nargotra, Ram A Vishwakarma, Sanghapal D Sawant
A strategy for construction of medicinally important 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones has been devised and presented here. The compounds have been synthesized using one-pot multicomponent strategy under microwave assisted conditions. Triazolyl-quinazolinone based D-ring modified analogs are designed based on IC87114 scaffold, which is first known isoform selective inhibitor of PI3Kδ. Herein, we identified two triazolyl-quinazolinone compounds (5a and 5l) based on same scaffold with PI3Kγ specific inhibitory potential, the selectivity towards this isoform is well supported by in silico results, wherein, these compounds show better interaction and affinity and inhibitory activity for PI3Kγ rather than PI3Kδ...
April 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29384060/nanocarrier-based-advances-in-drug-delivery-to-tumor-an-overview
#5
Ankit Jain, Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava, Sanjay K Jain
BACKGROUND: Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in the 1-100 nm size regime in at least one dimension. OBJECTIVE: Nanotechnology in drug delivery has been evidenced into nanocarriers that possess distinct properties both in vitro and in vivo, which may be used in targeting drugs to various diseases especially tumors...
January 30, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29378433/passive-delivery-of-protein-drugs-through-transdermal-route
#6
Bivek Chaulagain, Ankit Jain, Ankita Tiwari, Amit Verma, Sanjay K Jain
Skin is the largest external organ in the human body but its use for therapeutic purposes has been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and optimum polarity are fortunate enough to be used on skin therapeutics. But, at a time where modern therapeutics is slowly shifting from use of small molecular drugs towards the use of macromolecular therapeutic agents such as peptides, proteins and nucleotides in origin, skin therapeutics need to be evolved accordingly to cater the delivery of these agents...
January 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29351081/characterization-of-phosphate-transporter-s-and-understanding-their-role-in-leishmania-donovani-parasite
#7
K J Sindhu, Amit Kumar Kureel, Sheetal Saini, Smita Kumari, Pankaj Verma, Ambak Kumar Rai
Inorganic phosphate (Pi) is shown to be involved in excretion of methylglyoxal (MG) in the promastigote form of Leishmania donovani parasite. Absence of Pi leads to its accumulation inside the parasite. Accumulation of MG is toxic to the parasite and utilizes glyoxylase as well as excretory pathways for its detoxification. In addition, Pi is also reported to regulate activities of ectoenzymes and energy metabolism (glucose to pyruvate) etc. Thus, it is known to cumulatively affect the growth of Leishmania parasite...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29241763/eltrombopag-reduces-clinically-relevant-thrombocytopenic-events-in-higher-risk-mds-and-aml
#8
Aditi Shastri, Amit K Verma
No abstract text is available yet for this article.
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29204925/ultrasound-based-triggered-drug-delivery-to-tumors
#9
REVIEW
Ankit Jain, Ankita Tiwari, Amit Verma, Sanjay K Jain
Over the past few decades, applications of ultrasound (US) in drug delivery have been documented widely for local and site-specific release of bioactives in a controlled manner, after acceptable use in mild physical therapy for tendinitis and bursitis, and for high-energy applications in fibroid ablation, cataract removal, bone fracture healing, etc. US is a non-invasive, efficient, targetable and controllable technique. Drug delivery can be enhanced by applying directed US in terms of targeting and intracellular uptake...
February 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29108238/sites-of-extranodal-involvement-are-prognostic-in-patients-with-stage-1-follicular-lymphoma
#10
Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S Londono, Amit K Verma, Stefan K Barta
Objectives: Follicular lymphoma (FL) is the most common indolent B cell lymphoma in the United States and a quarter of patients present with stage I disease. The objective of this study was to examine if primary site of disease influences survival in early stage lymphoma. Results: The most common extranodal primary sites were the integumentary system (8%), followed by the GI tract (6.4%) and head & neck (5.6%). We stratified patients into a pre-rituximab era (1983-1998) and the rituximab era (1999-2011)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097284/mechanism-of-radioprotection-by-dihydroxy-1-selenolane-dhs-effect-of-fatty-acid-conjugation-and-role-of-glutathione-peroxidase-gpx
#11
Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K Indira Priyadarsini
Dihydroxy-1-selenolane (DHS) previously reported to exhibit radioprotective activity was investigated to understand its mechanism of action in CHO cells of epithelial origin. DHS pre-treatment at 25 μM for 16 h significantly protected CHO cells from radiation (4-11 Gy)-induced delayed mitotic cell death. Further to examine, how increased cellular uptake can influence this mechanism, studies have been performed with DHS-C6 , a lipophilic conjugate of DHS. Accordingly CHO cells pre-treated with DHS-C6 , showed increased survival against radiation exposure...
January 2018: Biochimie
https://www.readbyqxmd.com/read/28970655/liraglutide-as-an-alternative-to-insulin-for-glycemic-control-in-intensive-care-unit-a-randomized-open-label-clinical-study
#12
Vishesh Verma, Narendra Kotwal, Vimal Upreti, Monish Nakra, Yashpal Singh, K Anand Shankar, Amit Nachankar, K V S Hari Kumar
BACKGROUND: Intravenous insulin is the cornerstone in the management of hyperglycemia in the Intensive Care Unit (ICU). We studied the efficacy of liraglutide compared with insulin in the ICU. MATERIALS AND METHODS: In this prospective, open-labeled, randomized study, we included 120 patients (15-65 years, either sex) admitted to ICU with capillary blood glucose (CBG) between 181 and 300 mg/dl. We excluded patients with secondary diabetes and APACHE score >24...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28714383/novel-mannich-bases-as-potential-anticonvulsants-syntheses-characterization-and-biological-evaluation
#13
Amit Kumar Keshari, Aseem Tewari, Shweta Singh Verma, Shailendra K Saraf
BACKGROUND: Mannich bases are known to be an important pharmacophore or bioactive leads in the synthesis of various potential agents that have a variety of therapeutic activities like anticancer, antipsychotic, anticonvulsant, antimalarial, anti-inflammatory, antibacterial and so forth. Thus, in the present research, conjugation of moieties like 1,5-benzoxazepines and 1,5-benzothiazepines with secondary amines like piperazine, methyl piperazine and morpholine was carried out in a Mannich base with an anticipation of good anticonvulsant activity...
July 17, 2017: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28708503/effect-of-dietary-supplementation-of-omega-3-polyunsaturated-fatty-acid-pufa-rich-fish-oil-on-reproductive-performance-of-the-goat-capra-hircus
#14
RANDOMIZED CONTROLLED TRIAL
Ajit Singh Mahla, Ravjibhai K Chaudhari, Atul Kumar Verma, Amit Kumar Singh, Sanjay Kumar Singh, Gyanendra Singh, Mihir Sarkar, Narayan Dutta, Harendra Kumar, Narayanan Krishnaswamy
Dietary supplementation of n-3 PUFA decreases the luteolytic PGF2α and improves the pregnancy rate in the dairy cow. However, its effect in the goat is not known. Accordingly, we studied the effect of supplementation of n-3 PUFA rich Fish oil (FO) on different reproductive events in the goat. Cycling goats (n = 30) were divided into two equal groups and fed an isocaloric and isonitrogenous diet supplemented with either FO (TRT; n = 15) or palm oil (PO) (CON; n = 15) @ 0.6 mL/kg body weight for 72 days during the breeding season...
September 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28684379/pharmacokinetics-directed-intravenous-busulfan-combined-with-high-dose-melphalan-and-bortezomib-as-a-conditioning-regimen-for-patients-with-multiple-myeloma
#15
Stefan K Barta, Rishi Jain, Amithaba Mazumder, Jason Carter, Lawrence Almanzar, Roy Browne, Samira Shahnaz, Richard Elkind, David Kaminetzky, Ramakrishna Battini, Olga Derman, Noah Kornblum, Amit Verma, Ira Braunschweig
BACKGROUND: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has a well-established role in the treatment of patients with multiple myeloma. Melphalan 200 mg/m(2) (Mel200) is the most commonly used preparative regimen. Several studies have provided evidence for potential synergism and safety when combining bortezomib (Btz) or busulfan (Bu) with melphalan (Mel). PATIENTS AND METHODS: We conducted a prospective phase II study to investigate the safety and efficacy of conditioning with pharmacokinetics (PK)-directed intravenous (IV) Bu with Btz and Mel...
October 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28675459/stimulation-of-adrenergic-activity-by-desipramine-enhances-hematopoietic-stem-and-progenitor-cell-mobilization-along-with-g-csf-in-multiple-myeloma-a-pilot-study
#16
Aditi Shastri, Anjali Budhathoki, Stefan K Barta, Noah Kornblum, Olga Derman, Ramakrishna Battini, Radha Raghupathy, Amit K Verma, Paul S Frenette, Ira Braunschweig, Murali Janakiram
Hematopoietic stem cell (HSC) release is positively regulated by the sympathetic nervous system through the β3 adrenergic receptor. Preclinical studies have demonstrated that the combination of desipramine and G-CSF resulted in improved HSC mobilization. Here, we present the results of an open-label single-arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G-SCF to induce HSC mobilization. The primary endpoint was safety of the combination including engraftment kinetics...
October 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28636756/chemical-composition-and-allelopathic-antibacterial-antifungal-and-antiacetylcholinesterase-activity-of-fish-mint-houttuynia-cordatathunb-from-india
#17
Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Ajay Kumar, Hina Iqbal, Rajesh K Verma, Debabrata Chanda, Amit Chauhan, Dharmendra Saikia
Fish-mint (Houttuynia cordataThunb.), belonging to family Saururaceae, has long been used as food and traditional herbal medicine. The present study was framed to assess the changes occurring in the essential-oil composition of H. cordata during annual growth and to evaluate allelopathic, antibacterial, antifungal, and antiacetylcholinesterase activities. The essential-oil content ranged from 0.06 - 0.14% and 0.08 - 0.16% in aerial parts and underground stem, respectively. The essential oils were analysed by GC-FID, GC/MS, and NMR (1 H and13 C)...
October 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28585369/chemical-composition-and-antibacterial-antifungal-allelopathic-and-acetylcholinesterase-inhibitory-activities-of-cassumunar-ginger
#18
Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Sajendra K Verma, Hina Iqbal, Debabrata Chanda, Rajesh K Verma, Mahendra P Darokar, Amit Chauhan, Manish K Kandwal
BACKGROUND: Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae), commonly known as cassumunar-ginger, is a folk remedy for the treatment of inflammations, sprains, rheumatism and asthma. The aim of the present study was to assess the chemical composition, and antibacterial, antifungal, allelopathic and acetylcholinesterase inhibitory activities of the essential oil of Z. montanum originating from India. RESULTS: The hydrodistilled essential oil of Z. montanum rhizome was analyzed using gas chromatography-flame ionization detection and gas chromatography-mass spectrometry...
January 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28503683/cellular-evaluation-of-diselenonicotinamide-dsna-as-a-radioprotector-against-cell-death-and-dna-damage
#19
M Raghuraman, Prachi Verma, Amit Kunwar, Prasad P Phadnis, V K Jain, K Indira Priyadarsini
Diselenonicotinamide (DSNA), a synthetic organoselenium compound, was evaluated for its radioprotective effect in cellular models. A clonogenic assay in Chinese Hamster Ovary (CHO) cells and an apoptosis assay in murine splenic lymphocytes indicated that pre-treatment with DSNA at a concentration of 25 μM significantly protected them from radiation-induced cell death. Upon irradiation (1-12 Gy), dose-response studies were carried out under similar treatment conditions, and its dose modification factor (DMF) was estimated to be 1...
June 1, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28486913/pharmacophore-3d-qsar-models-and-dynamic-simulation-of-1-4-benzothiazines-for-colorectal-cancer-treatment
#20
Amit Rai, Vinit Raj, Mohamed H Aboumanei, Ashok K Singh, Amit K Keshari, Suraj P Verma, Sudipta Saha
AIM AND OBJECTIVE: Interleukin-6 has become an attractive protein target. This is found in the progression of colon cancer. It performs various functions in the colon cancer cells such as inflammation, activates various cell types signaling and also promotes proliferation in colon cancer cells. It is a valid target to develop anticolon cancer drug. The purpose of our study is to develop the Three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) models, pharmacophore modeling and docking study as well as MD simulation to find out the novel potent inhibitors that bind with Interleukin-6 in colon cancer treatment...
2017: Combinatorial Chemistry & High Throughput Screening
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