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https://www.readbyqxmd.com/read/27926912/cranioplasty-after-craniectomy-in-a-pediatric-population-single-center-experience-from-a-developing-country
#1
Muhammad Waqas, Badar Ujjan, Yousaf Bashir Hadi, Faizuddin Najmuddin, Altaf Ali Laghari, Swaleha Khalid, Muhammad Ehsan Bari, Umar Farooq Bhatti
Cranioplasty is a frequently performed procedure in neurosurgery. The pediatric population for this procedure is distinct from the adult one because of the growing skulls and thinner bones of the calvarium. A paucity of data on the outcomes of this procedure in the pediatric population has been identified repeatedly. We conducted a retrospective cohort study to investigate the outcomes in a pediatric population that underwent cranioplasty after craniectomy at our institute in a developing-world country. Our cohort showed no association of complication rate or cosmetic outcomes with the timing of cranioplasty, area of skull defect, type of implant used, or method of storage...
December 8, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27926909/dexamethasone-implant-in-chronic-diabetic-macular-edema-resistant-to-intravitreal-ranibizumab-treatment
#2
Ozlem Eski Yucel, Ertugrul Can, Hilal Eser Ozturk, Hakki Birinci, Yuksel Sullu
PURPOSE: The aim of this study was to assess the efficacy of a single intravitreal dexamethasone implant (IDI) over 6 months in eyes with chronic diabetic macular edema (DME) that were resistant to intravitreal ranibizumab (IR) treatment. METHODS: This retrospective study was conducted at the Ondokuz Mayis University Hospital, Samsun, Turkey. Efficacy outcomes were considered as the change from baseline in best corrected visual acuity (BCVA) and central macular thickness (CMT)...
December 8, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27926827/decoding-hand-gestures-from-primary-somatosensory-cortex-using-high-density-ecog
#3
Mariana P Branco, Zachary V Freudenburg, Erik J Aarnoutse, Martin G Bleichner, Mariska J Vansteensel, Nick F Ramsey
Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Still, target areas for BCI are not confined to M1, and more brain regions may provide suitable BCI control signals. A logical candidate is the primary somatosensory cortex (S1), which not only shares similar somatotopic organization to M1, but also has been suggested to have a role beyond sensory feedback during movement execution...
December 4, 2016: NeuroImage
https://www.readbyqxmd.com/read/27926686/orthopaedic-trauma-care-capacity-assessment-and-strategic-planning-in-ghana-mapping-a-way-forward
#4
Barclay T Stewart, Adam Gyedu, Gavin Tansley, Dominic Yeboah, Forster Amponsah-Manu, Charles Mock, Wilfred Labi-Addo, Robert Quansah
BACKGROUND: Orthopaedic conditions incur more than 52 million disability-adjusted life years annually worldwide. This burden disproportionately affects low and middle-income countries, which are least equipped to provide orthopaedic care. We aimed to assess orthopaedic capacity in Ghana, describe spatial access to orthopaedic care, and identify hospitals that would most improve access to care if their capacity was improved. METHODS: Seventeen perioperative and orthopaedic trauma care-related items were selected from the World Health Organization's Guidelines for Essential Trauma Care...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27926579/the-influence-of-coronary-plaque-morphology-assessed-by-optical-coherence-tomography-on-final-microvascular-function-after-stenting-in-patients-with-st-elevation-myocardial-infarction
#5
Giovanni L De Maria, Niket Patel, Mathias Wolfrum, Gregor Fahrni, George Kassimis, Italo Porto, Sam Dawkins, Robin P Choudhury, John C Forfar, Bernard D Prendergast, Keith M Channon, Rajesh K Kharbanda, Hector M Garcia-Garcia, Adrian P Banning
OBJECTIVES: The index of microcirculatory resistance (IMR) provides a reproducible assessment of the status of coronary microvasculature in patients with ST-elevation myocardial infarction (STEMI). Frequency-domain optical coherence tomography (FD-OCT) enables detailed assessment of the morphology of coronary plaque.We sought to determine the influence of the initial culprit coronary plaque anatomy within the infarct-related artery on IMR after stenting in STEMI. PATIENTS AND METHODS: In 25 STEMI patients IMR was measured immediately before and after stent implantation...
December 6, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27926564/systematic-review-and-meta-analysis-of-prophylactic-mesh-during-primary-stoma-formation-to-prevent-parastomal-hernia
#6
Stephen J Chapman, Benjamin Wood, Thomas M Drake, Neville Young, David G Jayne
BACKGROUND: Implantation of mesh at the time of stoma formation may reduce the rate of parastomal hernia. Until recently, the evidence has been limited to only a few small randomized controlled trials. OBJECTIVE: We present an updated systematic review and meta-analysis to assess the effect of mesh prophylaxis on rates of parastomal hernia. We examine ongoing and unpublished trials via online registries and propose recommendations for future research. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Library were searched up to March 2016 for published randomized controlled trials...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926562/long-term-experience-of-magnetic-anal-sphincter-augmentation-in-patients-with-fecal-incontinence
#7
Jeremy Sugrue, Paul-Antoine Lehur, Robert D Madoff, Shane McNevin, Steen Buntzen, Søren Laurberg, Anders Mellgren
BACKGROUND: Magnetic anal sphincter augmentation is a novel technique for the treatment of patients with fecal incontinence. OBJECTIVE: The current study reports the long-term effectiveness and safety of this new treatment modality. DESIGN: This was a prospective multicenter pilot study. SETTINGS: The study was performed at 4 clinical sites in Europe and the United States. PATIENTS: The cohort included patients with severe fecal incontinence for ≥6 months who had previously failed conservative therapy and were implanted with a magnetic anal sphincter device between 2008 and 2011...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926489/suppression-of-immune-regulatory-cells-with-combined-therapy-of-celecoxib-and-sunitinib-in-renal-cell-carcinoma
#8
Qi Zhao, Jianming Guo, Guomin Wang, Yiwei Chu, Xiaoyi Hu
OBJECTIVE: To observe the the potential benefit of sunitinib in combination with cyclooxygenase-2(COX-2) inhibitor in renal cell carcinoma therapy. METHODS: 769-p cell lines were treated with sunitinib, celecoxib, or in combination at different concentrations respectively. We investigated the expression of granulocyte-macrophage colony stimulating factor (GM-CSF) in 769-p and cell proliferation in vitro. BALB/c mice implanted with Renca cells were divided into 4 groups and administered orally by gavage with sunitinib, COX-2 inhibitor (celecoxib) monotherapy or combination, and PBS respectively...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926465/freestyle-stentless-bioprosthesis-for-aortic-valve-therapy-17-year-clinical-results
#9
Juergen Ennker, Markus Meilwes, Joern Pons-Kuehnemann, Bernd Niemann, Philippe Grieshaber, Ina C Ennker, Andreas Boening
BACKGROUND: Aortic valve replacement with stentless bioprostheses has been shown to produce lower aortic gradients than stented bioprostheses, thus facilitating left ventricular mass regression and preventing heart failure. We sought to determine the long-term results of stentless biological aortic valve replacement over a 17-year follow-up. METHODS: Between 1996 and 2012, 2551 patients underwent isolated aortic valve replacement with a stentless prosthesis (Medtronic Freestyle) at a single center...
November 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27925774/influence-of-backscatter-radiation-on-cranial-reconstruction-implants
#10
Yoshiaki Sakamoto, Naoyoshi Koike, Hideyuki Takei, Mari Ohno, Tomoru Miwa, Kazunari Yoshida, Naoyuki Shigematsu, Kazuo Kishi
OBJECTIVES: We aimed to evaluate backscatter dose variations in different cranial bone implant materials in an experimental model designed to simulate postoperative radiotherapy. METHODS: We assessed the radiation backscatter doses associated with sheet and mesh type titanium plates and hydroxyapatite (HAP) samples (porosity, 35%, 50%, and 85%). The samples were irradiated with 6 MV and 10 MV photon beams from a linear accelerator. Measurements were obtained using an ionization chamber and radiochromic films cut from the same batch...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27925636/on-the-2d-simplification-of-3d-bone-implant-systems-application-to-a-femoral-cementless-hip-stem
#11
Fernando J Quevedo González, Michael Reimeringer, Natalia Nuño
Three-dimensional (3D) finite element (FE) models are commonly used to analyze the mechanical behavior of the bone under different conditions (i.e. before and after arthroplasty). They can provide detailed information but they are numerically expensive and this limits their use in cases where large or numerous simulations are required. On the other hand, 2D models show less computational cost but the precision of results depends on the approach used for the simplification. Two main questions arise: are the 3D results adequately represented in a 2D section of the model? Which approach should be used to build a 2D model that provides reliable results compared to the 3D model? In this paper, we first evaluate if the plane used for generating the 2D models of bone-implant systems adequately represents the results of the full 3D model...
December 7, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27925634/influence-of-implant-surface-texture-design-on-peri-acetabular-bone-ingrowth-a-mechanobiology-based-finite-element-analysis
#12
Kaushik Mukherjee, Sanjay Gupta
The fixation of uncemented acetabular components largely depends on the amount of bone ingrowth, which is influenced by the design of the implant surface texture. The objective of this numerical study is to evaluate the effect of these implant texture design factors on bone ingrowth around an acetabular component. The novelty of this study lies in comparative Finite Element analysis of 3D microscale models of the implant-bone interface, considering patient-specific mechanical environment, host bone material property and implant-bone relative displacement, in combination with sequential mechanoregulatory algorithm and design of experiment based statistical framework...
December 7, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27925592/enzyme-free-scalable-dna-digital-design-techniques-a-review
#13
Aby Konampurath George, Harpreet Singh
With the recent developments in DNA nanotechnology, DNA has been used as the basic building block for the design of nanostructures, autonomous molecular motors, various devices, and circuits. DNA is considered as a possible candidate for replacing silicon for designing digital circuits in a near future, especially in implantable medical devices, because of its parallelism, computational powers, small size, light weight, and compatibility with bio-signals. The research in DNA digital design is in early stages of development, and electrical and computer engineers are not much attracted towards this field...
December 2, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27925583/modeling-electrode-place-discrimination-in-cochlear-implant-stimulation
#14
Xiao Gao, David Bruce Grayden, Mark D McDonnell
OBJECTIVE: By modeling the cochlear implant (CI) electrode-to-nerve interface and quantifying electrode discriminability in the model, we address the questions of how many individual channels can be distinguished by CI recipients and the extent to which performance might be improved by inserting electrodes deeper into the cochlea. METHOD: We adapt an artificial neural network to model electrode discrimination, as well as a commonly used psychophysical measure (four-interval forcedchoice) in CI stimulation and predict how well the locations of the stimulating electrodes can be inferred from simulated auditory nerve spiking patterns...
December 1, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27925461/in-it-for-the-long-haul-the-cytocompatibility-of-aged-graphene-oxide-and-its-degradation-products
#15
Brian D Holt, Anne M Arnold, Stefanie A Sydlik
Synthetic biomaterials are poised to transform medicine; however, current synthetic options have yet to ideally recapitulate the desirable properties of native tissue. Thus, the development of new synthetic biomaterials remains an active challenge. Due to its excellent properties, including electrical conductivity, water dispersibility, and capacity for functionalization, graphene oxide (GO) holds potential for myriads of applications, including biological devices. While many studies have evaluated the compatibility of freshly prepared GO, understanding the compatibility of GO as it ages in an aqueous environment is crucial for its safe implementation in long-term biological applications...
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27925441/anodized-3d-printed-titanium-implants-with-dual-micro-and-nano-scale-topography-promote-interaction-with-human-osteoblasts-and-osteocyte-like-cells
#16
Karan Gulati, Matthew Prideaux, Masakazu Kogawa, Luis Lima-Marques, Gerald J Atkins, David M Findlay, Dusan Losic
The success of implantation of materials into bone is governed by effective osseointegration, requiring biocompatibility of the material and the attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nano-scale topography have been suggested as essential. In this study, we present bone implants based on 3D-printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron-sized spherical particles and vertically aligned titania nanotubes...
December 7, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27925339/incidence-of-cardiac-perforation-with-conventional-and-with-leadless-pacemaker-systems-a-systematic-review-and-meta-analysis
#17
Mate Vamos, Julia W Erath, Alexander P Benz, Zsolt Bari, Gabor Z Duray, Stefan H Hohnloser
INTRODUCTION: Two leadless pacemaker (PM) systems were recently developed to avoid pocket- and lead-related complications. As leadless PMs are implanted with a large delivery catheter, cardiac perforation remains a major safety concern. We aimed to provide a literature review on incidence of cardiac perforation with conventional and with leadless PM systems. METHODS AND RESULTS: A systematic review over the last 25 years for studies reporting data on PM lead perforation was performed...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27925332/left-atrial-appendage-closure-with-the-new-occlutech%C3%A2-device-first-in-man-experience-and-neurological-outcome
#18
Barbara Bellmann, Steffen Schnupp, Peter Kühnlein, Christian Javernik, Caroline Kleinecke, Andreas Rillig, Ulf Landmesser, Johannes Brachmann, Jai-Wun Park
AIMS: Percutaneous left atrial appendage closure (LAAC) is a valuable treatment option for stroke prevention in patients with atrial fibrillation and a HAS-BLED-Score ≥ 3. Determinants of procedural safety events and neurological outcome of the patients with the Occlutech Device (OD) are not established yet. METHODS AND RESULTS: Between 2012 and 2016, 30 patients underwent LAAC using the OD. This is a prospective, study. Neurological examination and transesophageal echocardiography was performed directly before and after the procedure and after 1, 3 and 12 months...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27925308/impact-of-calcified-target-lesions-on-the-outcome-of-percutaneous-coronary-intervention-for-acute-coronary-syndrome-insights-from-the-base-acs-trial
#19
Pasi P Karjalainen, Wail Nammas, Kari Kervinen, Adam de Belder, Fernando Rivero-Crespo, Antti Ylitalo, Juhani K E Airaksinen
OBJECTIVES: We performed a post hoc analysis of outcome in patients with, versus those without, calcified target lesions from the BASE ACS trial. BACKGROUND: The outcome of contemporary stent implantation in patients with calcified lesions presenting with acute coronary syndrome is unknown. METHODS: The BASE ACS trial randomized 827 patients (1:1) presenting with acute coronary syndrome to receive either titanium-nitride-oxide-coated stents or everolimus-eluting stents...
December 7, 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27925240/closed-reduction-and-fluoroscopic-assisted-percutaneous-pinning-of-42-physeal-fractures-in-37-dogs-and-4-cats
#20
Christina L Boekhout-Ta, Stanley E Kim, Alan R Cross, Antonio Pozzi, Richard Evans
OBJECTIVE: To report complications and clinical outcome of dogs and cats that underwent fluoroscopic-assisted percutaneous pinning (FAPP) of physeal fractures. STUDY DESIGN: Retrospective study. ANIMALS: Client-owned dogs (n = 37) and cats (n = 4). MATERIALS AND METHODS: Records (August 2007-August 2014) of physeal fractures treated with FAPP in 3 hospitals were evaluated. Data collected included signalment, fracture characteristics (etiology, location, duration, Salter-Harris classification, preoperative and postoperative displacement), surgical information (implant size, surgical duration), and outcome assessment information (functional outcome, radiographic outcome, and complications)...
December 7, 2016: Veterinary Surgery: VS
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