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https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#1
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29649543/fate-of-recurrent-or-persistent-varicocele-in-the-era-of-assisted-reproduction-technology-microsurgical-subinguinal-redo-varicocelectomy-versus-observation
#2
Selahittin Çayan, Erdem Akbay
OBJECTIVE: To compare sperm parameters, serum hormone levels, pregnancy and miscarriage rates between the infertile men with recurrent or persistent varicocele who underwent microsurgical subinguinal redo varicocelectomy or had observation only. METHODS: The study included 217 primary infertile men with recurrent or persistent varicocele. The patients were divided into two groups: 120 men underwent microsurgical subinguinal redo varicocelectomy, and 97 had observation only...
April 9, 2018: Urology
https://www.readbyqxmd.com/read/29627606/gestational-exposure-to-ziram-disrupts-rat-fetal-leydig-cell-development
#3
Jianpeng Liu, Yiyan Wang, Yinghui Fang, Chaobo Ni, Leikai Ma, Wenwen Zheng, Suhao Bao, Xiaoheng Li, Qingquan Lian, Ren-Shan Ge
Ziram is an endocrine disruptor and may cause birth abnormality of the male reproductive system. However, the effects of ziram on fetal Leydig cell (FLC) development are still unknown. The objective of the present study was to determine the endocrine-disrupting effect of ziram on rat FLC development after gestational exposure. Pregnant Sprague Dawley dams were randomly divided into 5 groups and were gavaged with 0 (corn oil, the control), 1, 2, 4, or 8 mg/kg ziram from gestational day 12 (GD12) to GD21. FLC development was evaluated by measuring serum testosterone, FLC number and distribution, and the expression levels of Leydig and Sertoli cell genes...
March 21, 2018: Chemosphere
https://www.readbyqxmd.com/read/29627429/gestational-exposure-to-tetrabutyltin-blocks-rat-fetal-leydig-cell-development
#4
Yaoyao Dong, Yu Zhao, Qiqi Zhu, Zhe Wang, Yuanyuan Shan, Benson T Akingbemi, Ruijie Chen, Lihe Zhu, Ren-Shan Ge
Tetrabutyltin is a stable organotin and may exhibit endocrine disrupting properties. Herein, we investigated effects of tetrabutyltin on the development of rat fetal Leydig cells, which support differentiation of the male reproductive tract in late gestation. Female pregnant Sprague Dawley rats were gavaged with tetrabutyltin (0, 100, 200, and 500 mg/kg) from gestational day (GD) 12 to GD 21. Tetrabutyltin dose-dependently decreased testicular testosterone levels (0.756 ± 0.208 and 0.813 ± 0.277 ng/testis at the 200 and 500 mg/kg doses, respectively) compared to control (1...
April 5, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29627420/exercise-training-causes-a-partial-improvement-through-increasing-testosterone-and-enos-for-erectile-function-in-middle-aged-rats
#5
Dae Yun Seo, Sung Ryul Lee, Hyo Bum Kwak, Hyuntea Park, Kyo Won Seo, Yeon Hee Noh, Kang-Moon Song, Ji-Kan Ryu, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
PURPOSE: Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and penile eNOS levels in aging rats. METHODS: A total of 14 young (2-month-old) and 14 middle-aged (18-month-old) Sprague Dawley rats were randomly assigned to either untrained control (young control, [YC], middle-aged control, [MC]) or endurance exercise-trained (young exercise, [YE], middle-aged exercise, [ME]) groups with seven rats per group...
April 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29626673/assessment-of-gonadotropins-and-testosterone-hormone-levels-in-regular-mitragyna-speciosa-korth-users
#6
Darshan Singh, Vikneswaran Murugaiyah, Shahrul Bariyah Sahul Hamid, Vicknasingam Kasinather, Michelle Su Ann Chan, Eric Tatt Wei Ho, Oliver Grundmann, Nelson Jeng Yeou Chear, Sharif Mahsufi Mansor
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels. AIM OF THE STUDY: Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29623702/testosterone-replacement-muscle-strength-and-physical-function
#7
REVIEW
You Seon Nam, Gyeongsil Lee, Jae Moon Yun, Belong Cho
Muscle strength and physical function decrease in older men, as do testosterone levels. Nonetheless, the effects of testosterone replacement therapy on muscle strength and physical function remain inconclusive and equivocal. We conducted a rapid systematic review, the results of which showed that testosterone replacement does not affect muscle strength (measured by hand grip strength and leg muscle strength), although it may increase physical function (measured by the 6-minute walk test, Physical Activity Scale for the Elderly score, and other physical performance tests)...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29623694/which-exercise-is-better-for-increasing-serum-testosterone-levels-in-patients-with-erectile-dysfunction
#9
Jeong Kyun Yeo, Seung Ik Cho, Sun Gu Park, Seok Jo, Jeong Ku Ha, Jeong Woo Lee, Sung Yong Cho, Min Gu Park
PURPOSE: We investigated the correlations of serum total testosterone (TT) levels with body composition and physical fitness parameters in patients with erectile dysfunction (ED) to know the best exercise for testosterone deficiency. MATERIALS AND METHODS: Eighty-seven ED patients underwent serum TT assessment as well as body composition and basic exercise testing. The bioelectrical impedance analysis was used to assess body composition. Seven types of basic exercise tests were used to determine physical fitness...
January 26, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29621671/microcystin-leucine-arginine-mediates-apoptosis-and-engulfment-of-leydig-cell-by-testicular-macrophages-resulting-in-reduced-serum-testosterone-levels
#10
Yabing Chen, Jing Wang, Xiang Chen, Dongmei Li, Xiaodong Han
Microcystin-leucine arginine (MC-LR) causes decline of serum testosterone levels resulting in impaired spermatogenesis; however, the underlying molecular mechanisms are not fully understood. In this study, we aimed to investigate the effects of MC-LR exposure on the number of Leydig cells (LCs) in testis. Following chronic low dose exposure to MC-LR, the number of LCs was markedly decreased while macrophages were significantly increased. Then, we established a co-culture system to study the interaction between macrophages and LCs in the presence of MC-LR...
March 17, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29619752/is-a-previously-or-currently-reduced-testosterone-level-in-male-patients-with-type-2-diabetes-mellitus-a-risk-factor-for-the-development-of-coronary-artery-disease-a-systematic-review-and-meta-analysis
#11
Feng Huang
INTRODUCTION: We aimed to systematically investigate the association between testosterone level and cardiovascular risk in male patients with type 2 diabetes mellitus (T2DM) by comparing male T2DM patients with low testosterone levels to male T2DM patients with normal testosterone levels at baseline in terms of the number of cases of coronary artery disease (CAD). METHODS: Online databases were carefully searched for studies relating to testosterone, diabetes mellitus, and cardiovascular risk by using the search terms 'testosterone,' 'diabetes mellitus,' and 'coronary artery/cardiovascular disease...
April 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29615651/low-testosterone-in-apoe-ldl-receptor-double-knockout-mice-is-associated-with-rarefied-testicular-capillaries-together-with-fewer-and-smaller-leydig-cells
#12
Kai Steinfeld, Daniela Beyer, Christian Mühlfeld, Andrea Mietens, Gerrit Eichner, Bora Altinkilic, Marian Kampschulte, Qingkui Jiang, Gabriele A Krombach, Thomas Linn, Wolfgang Weidner, Ralf Middendorff
The testis as a site for atherosclerotic changes has so far attracted little attention. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone levels previously observed in extreme ages of this model. In KO mice, overall testosterone levels were reduced whereas the adrenal gland-specific corticosterone was increased excluding a general defect of steroid hormone production...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614340/maternal-lipopolysaccharide-exposure-results-in-glucose-metabolism-disorders-and-sex-hormone-imbalance-in-male-offspring
#13
Mei Zhao, Li Yuan, Man-Man Yuan, Li-Li Huang, Chang Su, Yuan-Hua Chen, Yu-Ying Yang, Yan Hu, De-Xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29611653/the-evaluation-of-blood-concentrations-of-testosterone-17%C3%AE-oestradiol-and-anti-mu%C3%A2-llerian-hormone-in-dogs-with-cryptorchidism-and-testicular-tumours
#14
L Hornakova, T Vrbovska, M Pavl'ak, A Valencakova-Agyagosova, M Halo, J Hajurka
Cryptorchidism and testicular tumours are very common disorders in dogs genitalia. The aim of the present study was o obtain an overview of serum 17β-oestradiol, anti-Muellerian hormone (AMH) and testosterone levels in intact dogs compared to dogs with different testicular tumours and dogs with cryptorchidism. Testosterone, AMH and 17β-oestradiol concentrations were measured in peripheral and local spermatic venous blood in dogs with unilateral cryptorchidism (n=8), dogs with neoplastic testicular diseases (n=8) and in a control group of mature intact dogs (n=8)...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29610568/longer-ta-repeat-but-not-v89l-polymorphisms-in-the-srd5a2-gene-may-confer-acne-risk-in-the-chinese-population
#15
Xue Hu, Wei Ding, Xinye Jin, Jia Wang, Dajin Zou, Yue Chen
Introduction: Several studies have reported that the V89L and TA repeat polymorphisms [(TA)n] of the SRD5A2 gene were associated with SRD5A2 activity. The activity of dihydrotestosterone, which is converted from testosterone by SRD5A2, is responsible for sebum secretion and the formation of acne. We hypothesized that abnormalities in SRD5A2 action could contribute to the formation of acne. Aim: To study whether the structural change of the SRD5A2 gene may affect the risk of acne in patients with normal serum testosterone levels...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29605576/effects-of-maternal-dietary-selenium-se-enriched-yeast-on-testis-development-testosterone-level-and-testicular-steroidogenesis-related-gene-expression-of-their-male-kids-in-taihang-black-goats
#16
Lei Shi, Ruigao Song, Xiaolei Yao, Yunli Duan, Youshe Ren, Chunxiang Zhang, Wenbin Yue, Fulin Lei
To investigate the effects of maternal dietary selenium (Se-enriched yeast) on testis development, testosterone level and steroidogenesis-related gene expression in testis of their male kids, selected pregnant Taihang Black Goats were randomly allotted to four treatment groups. They were fed the basal gestation and lactation diets supplemented with 0 (control), 0.5, 2.0 and 4.0 mg of Se/kg DM. Thirty days after weaning, testes were collected from the kids. After the morphological development status of testis was examined, tissue samples were collected for analyzing testosterone concentration and histological parameters...
March 26, 2018: Theriogenology
https://www.readbyqxmd.com/read/29604466/pon1-promoter-polymorphisms-contribute-to-pcos-susceptibility-and-phenotypic-outcomes-in-indian-women
#17
Roshan Dadachanji, Nuzhat Shaikh, Anushree Patil, Nalini Shah, Srabani Mukherjee
Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model...
March 28, 2018: Gene
https://www.readbyqxmd.com/read/29602044/effects-of-environmentally-relevant-sub-chronic-atrazine-concentrations-on-african-clawed-frog-xenopus-laevis-survival-growth-and-male-gonad-development
#18
Cornelius Rimayi, David Odusanya, Jana M Weiss, Jacob de Boer, Luke Chimuka, Felix Mbajiorgu
Sub-chronic toxicity of environmentally relevant atrazine concentrations on exposed tadpoles and adult male African clawed frogs (Xenopus laevis) was evaluated in a quality controlled laboratory for 90 days. The aim of this study was to determine the effects of atrazine on the survival, growth and gonad development of African clawed frogs. After exposure of tadpoles to atrazine concentrations of 0 (control), 0.01, 200 and 500 μg L-1 in water, mortality rates of 0, 0, 3.3 and 70% respectively were recorded for the 90 day exposure period...
March 23, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#19
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS & METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29600542/a-new-2-testosterone-gel-formulation-a-comparison-with-currently-available-topical-preparations
#20
REVIEW
S Arver, C Stief, J de la Rosette, T H Jones, A Neijber, D Carrara
Testosterone gel formulations have become a popular testosterone replacement therapy in patients with hypogonadism since their advent in the year 2000. The gel formulations restore testosterone levels to mid-normal physiological levels (14-17.5 nmol/L) as early as within 24 h, and help alleviate the signs and symptoms of testosterone deficiency, thereby leading to an improved quality of life. Although testosterone gels have a favourable efficacy and safety profile as compared to injectable and patch formulations, risk of secondary exposure poses a challenge...
March 30, 2018: Andrology
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