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https://www.readbyqxmd.com/read/29923212/statin-medications-and-the-risk-of-gynecomastia
#1
Sean C Skeldon, Bruce Carleton, James Brophy, Mohit Sodhi, Mahyar Etminan
OBJECTIVE: Case reports have suggested an increased risk of gynecomastia with HMG-CoA reductase inhibitors (i.e. statins). A recent meta-analysis also found that statins decrease circulating testosterone levels in men. We investigated whether statin use was associated with an increased risk of gynecomastia. DESIGN: Case control study. PATIENTS: A cohort of patients from a random sample of 9,053,240 US subjects from the PharMetrics Plus™ health claims database from 2006 to 2016 was created...
June 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29923211/beneficial-effect-of-apple-vinegar-on-reproductive-parameters-in-male-rat-model-of-nonalcoholic-fatty-liver-disease
#2
Fahimeh Mohammadghasemi, Masumeh Abbasi, Kamran Rudkhaneei, Monireh Aghajany-Nasab
Nonalcoholic fatty liver disease (NAFLD) is associated with low testosterone levels in serum. The aim of this study was to evaluate the effect of apple vinegar on fertility indices in a rat model of NAFLD. To study this effect, 32 adult male rats were divided into four groups: A-normal diet, B-high-fat diet (HFD), C-apple vinegar and D-HFD plus apple vinegar. At the end of the week 22, the Lee index, serum lipid profiles, liver enzymes, glucose and total antioxidant levels (TAC) in serum were determined. In addition, liver and testis tissue homogenate, histopathology, serum testosterone and sperm parameters were measured and HOMA-IR calculated...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29916947/factors-associated-with-developing-vaginal-dryness-symptoms-in-women-transitioning-through-menopause-a-longitudinal-study
#3
L Elaine Waetjen, Sybil L Crawford, Po-Yin Chang, Barbara D Reed, Rachel Hess, Nancy E Avis, Sioban D Harlow, Gail A Greendale, Sheila A Dugan, Ellen B Gold
OBJECTIVE: To evaluate factors associated with incident self-reported vaginal dryness and the consequences of this symptom across the menopausal transition in a multiracial/ethnic cohort of community-dwelling women. METHODS: We analyzed questionnaire and biomarker data from baseline and 13 approximately annual visits over 17 years (1996-2013) from 2,435 participants in the Study of Women's Health Across the Nation, a prospective cohort study. We used discrete-time Cox proportional-hazards regression to identify predictors of incident vaginal dryness and to evaluate vaginal dryness as a predictor of pain during intercourse and changes in sexual intercourse frequency...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29915504/effects-of-intratesticular-injection-of-zinc-based-solution-in-rats-in-combination-with-anti-inflammatory-and-analgesic-drugs-during-chemical-sterilization
#4
Simone Regina Barros de Macêdo, Luiz André Rodrigues de Lima, Sandra Maria de Torres, Vinícius Vasconcelos Gomes de Oliveira, Rosana Nogueira de Morais, Christina Alves Peixoto, Bruno Mendes Tenorio, Valdemiro Amaro da Silva Junior
Aim: Chemical sterilization is a non-surgical method of contraception based on compounds injected into the testis to induce infertility. However, these injections can cause discomfort and pain able to impair the recovery of animals after this treatment. The objective of this study was to investigate if anti-inflammatories or pain relievers inhibited the sterilizing effect of zinc gluconate-based solution on the testis. Materials and Methods: Adult rats were treated in groups: G1 (control), G2 (dimethyl sulfoxide + dipyrone); G3 (dipyrone/zinc); G4 (dipyrone + celecoxib/zinc); G5 (dipyrone + meloxicam/zinc), and G6 (dipyrone + dexamethasone/zinc) in a single dose per day during 7 days...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#5
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29904126/effect-of-testosterone-treatment-on-bone-remodelling-markers-and-mineral-density-in-obese-dieting-men-in-a-randomized-clinical-trial
#6
Mark Ng Tang Fui, Rudolf Hoermann, Brendan Nolan, Michelle Clarke, Jeffrey D Zajac, Mathis Grossmann
To assess the effect of testosterone treatment on bone remodelling and density in dieting obese men, 100 obese men aged 53 years (interquartile range 47-60) with a total testosterone level <12 nmol/L receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). Pre-specified outcomes were between-group differences (mean adjusted difference, MAD) in serum c-telopeptide (CTx), N-terminal propeptide of type 1 procollagen (P1NP) and bone mineral density (BMD)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904069/exposure-to-an-anti-androgenic-herbicide-negatively-impacts-reproductive-physiology-and-fertility-in-xenopus-tropicalis
#7
F Orton, M Säfholm, E Jansson, Y Carlsson, A Eriksson, J Fick, T Uren Webster, T McMillan, M Leishman, B Verbruggen, T Economou, C R Tyler, C Berg
Amphibians are threatened on a global scale and pollutants may be contributing to population declines, but how chemicals impact on their reproduction is poorly understood. We conducted a life cycle analysis to investigate the impacts of early life exposure to two anti-androgens (exposure until completion of metamorphosis;stage 66): flutamide, (50 µg/L)/linuron (9 and 45 µg/L)) on sexual development and breeding competence in Xenopus tropicalis. Our analyses included: mRNA levels of dmrt1, cyp17, amh, cyp19, foxl2 and ar (tadpoles/metamorphs), gonadal histomorphology (metamorphs/adults), mRNA levels of ar/gr (adult male brain/gonad/forelimb), testosterone/corticosterone levels (adult males), secondary sexual characteristics (forelimb width/nuptial pad: adult males) and breeding competence (amplexus/fertility: adult males)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902490/decreased-h3k9ac-level-of-star-mediated-testicular-dysplasia-induced-by-prenatal-dexamethasone-exposure-in-male-offspring-rats
#8
Min Liu, Biao Chen, Linguo Pei, Qi Zhang, Yunfei Zou, Hao Xiao, Jin Zhou, Liaobin Chen, Hui Wang
Prenatal dexamethasone exposure (PDE) could induce testicular developmental toxicity in adults. The present study aims to confirm its intrauterine origination, and to explore its potential intrauterine programming mechanism. The pregnant rats were respectively injected subcutaneously with 0.2 and 0.8 mg/kg⋅d dexamethasone during gestational days (GD) 9 to 20. The testes and serum of offspring rats were collected on GD20 and postnatal week (PW) 12. In vivo, PDE significantly induced the abnormal testicular morphology in offspring from GD20 to PW12...
June 11, 2018: Toxicology
https://www.readbyqxmd.com/read/29902186/no-relationship-between-autistic-traits-and-salivary-testosterone-concentrations-in-men-from-the-general-population
#9
Diana Weiting Tan, Murray T Maybery, Michael W Clarke, Renata Di Lorenzo, Melissa O Evans, Michael Mancinone, Christina Panos, Andrew J O Whitehouse
It is suggested that testosterone may play a part in the higher prevalence of Autism Spectrum Disorder (ASD) in males compared to females. Previous studies have reported elevated postnatal testosterone levels in children and women with ASD but not in men. We compared levels of salivary testosterone across 67 undergraduate males (Mage 19.5 yrs, SD 1.92) selected for low, mid-range and high levels of autistic traits assessed using the Autism-spectrum Quotient. Analyses revealed no significant differences in testosterone concentrations across the three groups...
2018: PloS One
https://www.readbyqxmd.com/read/29901265/adipose-tissue-is-a-potential-source-of-hyperandrogenism-in-obese-female-rats
#10
Isabel Viola Wagner, Lena Sahlin, Iuliia Savchuk, Nora Klöting, Konstantin Svechnikov, Olle Söder
OBJECTIVE: Obesity in females is often associated with metabolic complications and hyperandrogenism, but the sources of androgens are not completely understood. Therefore, this study investigated whether adipose tissue could be a source of androgens promoting hyperandrogenism development in obese female rats. METHODS: Gene expression of steroidogenic enzymes and testosterone levels were determined in periovarian and inguinal adipose tissue and in the supernatant of cultured preadipocytes and adipocytes...
June 14, 2018: Obesity
https://www.readbyqxmd.com/read/29899137/retinoic-acid-receptor-signaling-is-necessary-in-steroidogenic-cells-for-normal-spermatogenesis-and-epididymal-function
#11
Estela J Jauregui, Debra Mitchell, Traci Topping, Cathryn A Hogarth, Michael D Griswold
Spermatogenesis in mammals is a very complex, highly organized process, regulated in part by testosterone and retinoic acid (RA). There is a significant amount known about how RA and testosterone signaling pathways independently regulate this process, but there is almost no information regarding whether these two signaling pathways directly interact and whether RA is critical for steroidogenic cell function. This study utilized a transgenic mouse line that expresses a dominant negative form of RA receptor α (RAR-DN) and the steroidogenic cell-specific Cre mouse line, Cyp17 iCre, to generate male mice with steroidogenic cells unable to perform RA signaling...
June 13, 2018: Development
https://www.readbyqxmd.com/read/29897474/insulin-resistance-hyperinsulinemia-and-lh-relative-roles-in-peripubertal-obesity-associated-hyperandrogenemia
#12
Christine M Burt Solorzano, Karen L Knudsen, Amy D Anderson, Eleanor G Hutchens, Jessicah S Collins, James T Patrie, John C Marshall, Christopher R McCartney
Context: Peripubertal obesity is associated with variable hyperandrogenemia, but precise mechanisms remain unclear. Objective: To assess the roles of insulin resistance, hyperinsulinemia, and luteinizing hormone (LH) in peripubertal obesity-associated hyperandrogenemia. Design: Cross-sectional analysis. Setting: Academic clinical research unit. Participants: Eleven obese (body mass index-for-age ≥ 95%) peripubertal girls...
April 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29895278/observational-study-on-the-prognostic-value-of-testosterone-and-adiposity-in-postmenopausal-estrogen-receptor-positive-breast-cancer-patients
#13
Elisabetta Venturelli, Annalisa Orenti, Aline S C Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli
BACKGROUND: Despite the clear endocrine-metabolic relationship between androgenic activity and adiposity, the role of androgens in breast cancer prognosis according to patient's adiposity is scarcely explored. Here, we aimed at investigating the prognostic value of circulating testosterone in association with patient's body mass index (BMI). METHODS: Circulating testosterone and BMI were evaluated at breast cancer diagnosis in 460 estrogen receptor (ER)-positive postmenopausal patients...
June 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29895265/reintroducing-testosterone-in-the-db-db-mouse-partially-restores-normal-glucose-metabolism-and-insulin-resistance-in-a-leptin-independent-manner
#14
Koichi Yabiku, Keiko Nakamoto, Akihiro Tokushige
BACKGROUND: Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arteriosclerosis, obesity and diabetes. However, these findings have not been verified by testosterone replacement in animal models and whether or not testosterone acts directly by activating AR to enhance leptin signaling, or indirectly by its conversion into estrogen remains unclear...
June 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29893704/association-between-low-testosterone-levels-and-sarcopenia-in-cirrhosis-a-cross-sectional-study
#15
Carlos Moctezuma-Velázquez, Gavin Low, Marina Mourtzakis, Mang Ma, Kelly W Burak, Puneeta Tandon, Aldo J Montano-Loza
INTRODUCTION AND AIM: Sarcopenia is an independent predictor of mortality in cirrhosis. Hypogonadism is common in cirrhosis and has been associated with sarcopenia in non-cirrhotic chronic liver disease populations. The aim of this study is to investigate if sarcopenia is associated with low testosterone levels in patients with cirrhosis. MATERIAL AND METHODS: This is a retrospective analysis of prospectively collected data of 211 cirrhotic patients undergoing evaluation for liver transplantation...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29890281/mechanisms-of-testosterone-deficiency-related-endothelial-dysfunction
#16
EDITORIAL
Alexios S Antonopoulos, Charalambos Antoniades
Evidence from clinical studies suggests that patients with low testosterone levels are at increased cardiovascular disease risk. Even though the exact mechanisms remain poorly understood, low plasma testosterone is associated with a pro-atherogenic lipid profile, insulin resistance and increased levels of pro-inflammatory mediators, and vascular dysfunction which is typically observed in patients with hypogonadism. Furthermore, recent evidence suggests that testosterone deficiency has also direct adverse effects on endothelium and nitric oxide bioavailability...
June 8, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29888533/the-catch-checklist-to-investigate-adult-onset-hypogonadism
#17
REVIEW
G Defeudis, R Mazzilli, D Gianfrilli, A Lenzi, A M Isidori
Adult-onset hypogonadism is a syndrome often underdiagnosed, undertreated, or incompletely explored. There are various reasons for this: firstly, undefined age range of men in whom testosterone levels should be investigated and then no definitive serum cutoff point for the diagnosis of hypogonadism; and finally, variable and non-specific signs and symptoms; men and physicians do not pay adequate attention to sexual health. All these factors make the diagnostic criteria for hypogonadism controversial. The evaluation of the clinical features and causes of this syndrome, its link with age, the role of testosterone and other hormone levels, and the presence of any comorbidities are all useful factors in the investigation of this population...
June 10, 2018: Andrology
https://www.readbyqxmd.com/read/29887939/di-2-ethylhexyl-phthalate-increases-obesity-induced-damage-to-the-male-reproductive-system-in-mice
#18
Jian Zhao, Shi Ren, Chunyu Liu, Li Huo, Zheng Liu, Lingling Zhai
Objective: This study evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) and obesity on male reproductive organ function in male mice and the potential mechanism of male secondary hypogonadism (SH) in such mice. Methods: 140 mice were assigned to six groups for 12 weeks: normal, DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high. The effects of DEHP and obesity upon the reproductive organs were determined by measuring sperm count and motility, relative testis and epididymis weight, hormone level, and pathological changes...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29887901/effect-of-chamomile-capsule-on-lipid-and-hormonal-related-parameters-among-women-of-reproductive-age-with-polycystic-ovary-syndrome
#19
Maryam Heidary, Zahra Yazdanpanahi, Mohammad Hossain Dabbaghmanesh, Mohammad Ebrahin Parsanezhad, Masoumeh Emamghoreishi, Marzieh Akbarzadeh
Background: According to traditional herbal medicine, chamomile has been considered as one of the herbal remedies for patients with polycystic ovary syndrome (PCOS). The study aimed to investigate the effect of chamomile on lipid and hormonal parameters in women of reproductive age with PCOS. Materials and Methods: This study is a randomized clinical trial which was conducted on 80 women (40 patients in each group) of childbearing age with PCO. The intervention group received 370 mg oral capsules of chamomile three times a day for 3 months...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29887899/comparison-of-salivary-testosterone-levels-in-different-phases-of-bipolar-i-disorder-and-control-group
#20
Sabra Mousavizadegan, Mohsen Maroufi
Background: Testosterone is considered as a primary sex hormone, also known as an important anabolic steroid, that may involve in various mental disorders such as bipolar I disorder (BID). The goal of this study was to compare the testosterone salivary levels between different phases of BID and its association with the clinical features of BID. Materials and Methods: In a case-control study, 15 patients in the mania phase, 10 patients in the depression phase, and 16 in the euthymia phase were selected as patient groups...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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