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https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#1
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29026487/seasonal-variations-and-correlations-between-vitamin-d-and-total-testosterone-levels
#2
Moo-Yeol Sim, Soo-Hyun Kim, Kwang-Min Kim
BACKGROUND: Some studies have provided evidence for a possible association between vitamin D and testosterone levels; however, the evidence from studies in Koreans is inconsistent. In addition, insufficient evidence is available to support an association between seasonal variations in vitamin D and testosterone levels in Koreans. Therefore, we aimed to investigate the association between vitamin D and testosterone levels, and between seasonal variations in these levels in Korean men. METHODS: This cross-sectional study included 1,559 men, aged 25-86 years, who underwent a medical examination...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29025356/associations-between-sleep-deprivation-and-salivary-testosterone-levels-in-male-university-students-a-prospective-cohort-study
#3
Mahmoud Suleiman Abu-Samak, Beisan Ali Mohammad, May Ibrahim Abu-Taha, Luai Zidan Hasoun, Shady Helmi Awwad
Sleep deprivation is a common health problem that is growing rapidly worldwide and it is associated with short- and long-term impacts on health. The aim of this study was to detect potential predictors of salivary testosterone (sT) association with sleep deprivation in Arab male university students. In this prospective cohort study, 77 university male students in the age range of 18 to 26 years were divided into two groups, sleep-deprived (SD) participants and non-sleep-deprived (NSD) participants. Sleep deprivation was defined as sleeping less than 5 hr per night...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29023546/steroid-hormones-and-psychological-responses-to-soccer-matches-insights-from-a-systematic-review-and-meta-analysis
#4
Maamer Slimani, Julien S Baker, Foued Cheour, Lee Taylor, Nicola Luigi Bragazzi
The present systematic review and meta-analysis aimed to assess the perturbations in hormonal and psychological homeostasis in response to soccer match-play. These perturbations were explored according to match outcome (i.e., win versus loss), gender, type of contest (i.e., competitive versus non-competitive fixtures) and competitive level (i.e., novice versus high-level). The review was conducted according to the Population/Intervention or Exposure/Comparison/Outcome(s) (PICO) criteria and the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/29022899/transplanted-human-p75-positive-stem-leydig-cells-replace-disrupted-leydig-cells-for-testosterone-production
#5
Min Zhang, Jiancheng Wang, Chunhua Deng, Mei Hua Jiang, Xin Feng, Kai Xia, Weiqiang Li, Xingqiang Lai, Haipeng Xiao, Ren-Shan Ge, Yong Gao, Andy Peng Xiang
Previous studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a promising approach for the treatment of hypogonadism. Here, we isolated human SLCs prospectively and explored the potential therapeutic benefits of human SLC transplantation for hypogonadism treatment. In adult human testes, p75 neurotrophin receptor positive (p75(+)) cells expressed the known SLC marker nestin, but not the LC lineage marker hydroxysteroid dehydrogenase-3β (HSD3β)...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#6
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29018642/pulmonary-embolism-secondary-to-testosterone-enhancing-herbal-supplement-use
#7
Steven M Nguyen, Nway Ko Ko, Asad S Sattar, Esra Gucuk Ipek, Sayed Ali
Decreased testosterone levels in men are often a normal sign of aging. Testosterone replacement therapy (TRT) is a well-established option for those with symptomatic hypogonadism related to low testosterone levels. Conversely, designer herbal supplements in the context of testosterone supplementation are poorly studied, yet remain popular among aging men who seek the well-known, often enhancing, effects of testosterone that involve muscle mass and sexual function/drive. In 2014, the Food and Drug Administration (FDA) issued a warning about the significant risk of venous clots secondary to testosterone product use...
August 6, 2017: Curēus
https://www.readbyqxmd.com/read/28994489/short-term-resource-allocation-during-extensive-athletic-competition
#8
Daniel P Longman, Sean P Prall, Eric C Shattuck, Ian D Stephen, Jay T Stock, Jonathan C K Wells, Michael P Muehlenbein
OBJECTIVES: Following predictions from life history theory, we sought to identify acute trade-offs between reproductive effort (as measured by psychological arousal) and somatic maintenance (via functional measures of innate immunity) during conditions of severe energetic imbalance. METHODS: Sixty-six male ultramarathon runners (ages 20 to 37 years) were sampled before and after a lengthy race. Saliva and sera were collected for testosterone and immunological analyses (hemolytic complement activity and bacterial killing ability)...
October 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28994096/impaired-expression-of-testicular-androgen-receptor-and-collagen-fibers-in-the-testis-of-diabetic-rats-under-haart-the-role-of-hypoxis-hemerocallidea
#9
Onanuga O Ismail, Jegede I Ayoola, Offor Ugochukwu, Ogedengbe O Oluwatosin, Peter I Aniekan, Naidu C S Edwin, Azu O Onyemaechi
INTRODUCTION: Wide spectrum of alterations associated with highly active antiretroviral therapy (HAART) has been reported. The current study aimed at evaluating the role of Hypoxis hemerocallidea (HH) aqueous extract on the testosterone levels, expression of androgen receptors and collagen fibers in the testes of streptozotocin-nicotinamide-induced diabetic rats under HAART regimen. MATERIAL AND METHODS: Sixty two adult male Sprague-Dawley rats (189.0 ± 4.5 g) were divided into eight groups (8 animals in each treatment groups and 6 rats in the control group)...
October 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28993599/circulating-gonadotropins-and-testicular-hormones-during-sexual-maturation-and-annual-changes-in-male-bottlenose-dolphins-tursiops-truncatus
#10
Etsuko Katsumata, Sukanya Jaroenporn, Yoko Ueda, Kazutoshi Arai, Hiroshi Katsumata, Gen Watanabe, Kazuyoshi Taya
To reveal the reproductive biology in male bottlenose dolphins (Tursiops truncatus), circulating gonadotropins (follicle stimulating hormone [FSH] and luteinizing hormone [LH]) and testicular hormones (testosterone and inhibin) were monitored for 8 -12 years in 2 captive bottlenose dolphins (Mars and Regulus). During the study period, Mars was undergoing sexual maturation, whereas Regulus was already mature at the beginning of the study. Assuming that Mars had reached sexual maturity when the significant increase in circulating testosterone levels was observed, serum concentration of inhibin was higher in the sexually immature stage than in the mature stage, whereas the serum concentration of FSH was higher in the sexually mature stage than in the immature stage...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28993561/a-missense-variant-rs4645843-in-tnf-%C3%AE-gene-is-a-risk-factor-of-polycystic-ovary-syndrome-in-the-uygur-population
#11
Shan Li, Lei Zhao, Xiao-Hui Wan
Polycystic ovary syndrome (PCOS) is a complex endocrine syndrome, resulting from the interaction of gene variants and environmental factors. PCOS is viewed as a proinflammatory state and is characterized by hyperandrogenism, hyperinsulinemia, and over-weight. In China, the incidence of PCOS is higher in the Uygur population than that in the Chinese Han population. The association of the tumor necrosis factor α (TNF-α) gene with PCOS remains to be clarified. Here, we investigated the association of TNF-α polymorphisms with PCOS in the Uygur population (393 patients with PCOS and 381 healthy subjects)...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28992603/sex-steroid-hormones-and-sex-hormone-binding-globulin-levels-cyp17-msp-ai-34t-c-and-cyp19-codon-39-trp-arg-variants-in-children-with-developmental-stuttering
#12
Hiwa Mohammadi, Mohammad Taghi Joghataei, Zohreh Rahimi, Faezeh Faghihi, Habibolah Khazaie, Hashem Farhangdoost, Masoud Mehrpour
Developmental stuttering is known to be a sexually dimorphic and male-biased speech motor control disorder. In the present case-control study, we investigated the relationship between developmental stuttering and steroid hormones. Serum levels of testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), oestradiol, progesterone, cortisol, and sex hormone binding globulin (SHBG), as well as the 2nd/4th digit ratio (2D:4D), an indicator of prenatal testosterone level, were compared between children who stutter (CWS) and children who do not stutter (CWNS)...
October 6, 2017: Brain and Language
https://www.readbyqxmd.com/read/28990951/testosterone-replacement-therapy-and-cardiovascular-events
#13
Alp Burak Çatakoğlu, Muammer Kendirci
A low testosterone level and hypogonadism are associated with cardiovascular disease. Aging, chronic health problems, and obesity are all associated with a low testosterone level as well as the presence and severity of cardiovascular disease. Testosterone is increasingly prescribed for patients with clinical hypogonadism and a low testosterone level. The information we have is still contradictory regarding testosterone replacement therapy (TRT) and its association with adverse cardiovascular events. Older patients and patients who are susceptible to cardiovascular diseases could be at risk with a testosterone prescription...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28990055/defective-insulin-signaling-and-the-protective-effects-of-dimethyldiguanide-during-follicular-development-in-the-ovaries-of-polycystic-ovary-syndrome
#14
Fan Wang, Shaobing Wang, Zhenghong Zhang, Qingqiang Lin, Yiping Liu, Yijun Xiao, Kaizhuan Xiao, Zhengchao Wang
It is established that the physiological effects of insulin are primarily mediated by the insulin signaling pathway. However, a defective insulin signaling is closely associated with the clinical manifestations of polycystic ovary syndrome (PCOS), which include excess androgen levels, insulin resistance and anovulation, and is involved in the pathophysiology of PCOS at the molecular level. Dimethyldiguanide (DMBG) has been widely employed to alleviate reproduction dysfunction in women with PCOS, however, the exact mechanism of this effect remains unclear...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986172/nicotine-affects-rat-leydig-cell-function-in-vivo-and-vitro-via-down-regulating-some-key-steroidogenic-enzyme-expressions
#15
Xiaoling Guo, Huang Wang, Xiaolong Wu, Xianwu Chen, Yong Chen, Jingjing Guo, Xiaoheng Li, Qingquan Lian, Ren-Shan Ge
Nicotine is consumed largely as a component of cigarettes and has a potential effect on pubertal development of Leydig cells in males. To investigate its effects, 49-day-old male Sprague Dawley rats received intraperitoneal injections of nicotine (0.5 or 1 mg/kg/day) for 2 weeks and immature Leydig cells were isolated from the testes of 35-day-old rats and treated with nicotine (0.05-50 μM). Serum hormones, Leydig cell number and related gene expression levels after in vivo treatment were determined and medium androgen levels were measured and cell cycle, apoptosis, mitochondrial membrane potential (△Ψm), and reactive oxygen species (ROS) of Leydig cells after in vitro treatment were measured...
October 3, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28985536/perfluorooctane-sulfonate-impairs-rat-leydig-cell-development-during-puberty
#16
Lili Li, Xiaoheng Li, Xianwu Chen, Yong Chen, Jianpeng Liu, Fenfen Chen, Fei Ge, Leping Ye, Qingquan Lian, Ren-Shan Ge
Perfluorooctane sulfonate (PFOS) possibly delays male sexual development. However, its effects on pubertal Leydig cell development are unclear. The objective of the present study was to investigate the effects of in vivo PFOS exposure on rat Leydig cell development during puberty. Immature male Sprague Dawley rats were gavaged 5 or 10 mg/kg PFOS on postnatal day 35 for 21 days. Compared to the control (0 mg/kg), PFOS lowered serum testosterone levels without altering luteinizing hormone and follicle-stimulating hormone levels on postnatal day 56...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28984502/the-association-between-hypogonadism-symptoms-with-serum-testosterone-fsh-and-lh-in-men
#17
Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Mojtaba Mehrdad
OBJECTIVES: This study aimed to determine the relationship of hypogonadism symptoms with the levels of sex hormones in men. METHODS: This cross-sectional study was conducted on 140 men aged above 40 years. Data collections were conducted by Aging Male Scales (AMS) questionnaire and some sociodemographic variables. Then, 3 ml blood serum was sampled for testosterone (free and total), FSH and LH. Data were analyzed by descriptive and analytical statistics. RESULTS: Mean age score was 52...
October 6, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28983616/abnormal-expression-levels-of-bmp15-smad1-are-associated-with-granulosa-cell-apoptosis-in-patients-with-polycystic-ovary-syndrome
#18
Xiangrong Cui, Xuan Jing, Xueqing Wu, Xingyu Bi, Junfen Liu, Zhijing Long, Xiuping Zhang, Dongdong Zhang, Hongxiang Jia, Dan Su, Kai Huo
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive dysfunction and metabolism in women of childbearing age. An increasing number of studies have suggested that the bone morphogenetic protein 15 (BMP15) signalling pathway serves an important role in the pathogenesis of PCOS; however, the full mechanism remains unknown. The present study revealed that intrinsic follicular dysplasia may be associated with regulation disorders of ovarian granulosa cell apoptosis. Compared with the control group, body mass index, luteinising hormone and testosterone levels were significantly increased (P<0...
September 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982870/both-high-and-low-serum-total-testosterone-levels-indicate-poor-prognosis-in-patients-with-prostate-cancer
#19
Kouji Izumi, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Yoshifumi Kadono, Atsushi Mizokami
BACKGROUND/AIM: Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prognostic biomarker for prostate cancer, its usability is still controversial. We examined the potential and characteristics of TT as a biomarker. PATIENTS AND METHODS: Serum TT levels of patients who underwent prostate biopsy were measured, and prostate cancer-specific survival (PCaSS), overall survival (OS), and the correlation between staging and serum TT level were analyzed...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982028/effect-of-age-and-castration-on-serum-anti-m%C3%A3-llerian-hormone-concentration-in-male-alpacas
#20
Michela Ciccarelli, Ahmed Tibary, Alexis J Campbell, Alan J Conley
The synthesis of anti-Müllerian Hormone (AMH) by the Sertoli cells in males is crucial for sexual differentiation. There are no studies on AMH in Camelids. The objectives of this research were to 1) compare AMH serum concentrations in prepubertal and adult male alpacas and 2) determine the effect of castration on these concentrations in adult males to provide a validation of a commercial AMH test in alpacas. Serum samples were obtained from 15 prepubertal animals (5 for each age groups of 6, 7 and 8 months) and from 5 adult males (age 5-9 years), pre- and 24 h post-castration...
September 28, 2017: Theriogenology
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