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https://www.readbyqxmd.com/read/28822243/chrysin-induced-sperm-parameters-and-fatty-acid-profile-changes-improve-reproductive-performance-of-roosters
#1
Ali Sami Amin Altawash, Ahmad Zare Shahneh, Hossein Moravej, Mahdi Ansari
Having antioxidant and androgenic effects, Chrysin was orally administrated to roosters and reproductive performance including sperm quality and fatty acid composition, testis index, fertility and hatchability rates as well as blood testosterone concentration were assessed. Twenty eight 40-week-old Ross 308 roosters were individually housed, equally divided into four groups and received different levels of capsulated Chrysin including 0 (Ch0), 25 (Ch25), 50 (Ch50) or 75 (Ch75) mg/bird/day for 12 consecutive weeks...
August 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/28820276/attenuation%C3%A2-of-sulfite-induced-testicular-injury-in-rats-by-zingiber-officinale-roscoe
#2
Akbar Afkhami Fathabad, Shahnaz Shekarforoush, Maryam Hoseini, Zahra Ebrahimi
Sulfite salts, including sodium metabisulfte, are widely used as preservatives in foods and pharmaceutical agents. Previous studies suggest that oxidative stress may be an important mediator of testicular injury. The present study was designed to elucidate the effect of exposure to sodium metabisulfite by gavage without or with Zingiber officinale (ginger) extract on the rat testes. Thirty-two male Wistar rats were randomly divided into control, ginger-treated (500 mg/kg/day), sodium metabisulfite- (SMB-) treated (260 mg/kg/day), and SMB + ginger- (SZ-) treated groups...
August 18, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28817891/re-characterising-the-safety-of-clomiphene-citrate-in-male-patients-through-prostate-specific-antigen-haematocrit-and-testosterone-levels
#3
Craig Niederberger
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28816715/testosterone-therapy-improves-erectile-function-and-libido-in-hypogonadal-men
#4
Paul J Rizk, Taylor P Kohn, Alexander W Pastuszak, Mohit Khera
PURPOSE OF REVIEW: Erectile dysfunction and decreased libido are common complaints in the older male population. Recent studies have elucidated the role testosterone therapy (TTh) can play in men with low testosterone levels. The aim of this review is to provide an overview of these findings and the utility of TTh. We specifically examine the role of TTh on erectile function, coadministration with phosphodiesterase type 5 inhibitors, and libido. RECENT FINDINGS: Recent publications suggest that TTh improves mild erectile dysfunction, though may be less useful in men with more severe erectile dysfunction...
August 14, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28816201/risk-factors-and-the-prognosis-of-sexual-dysfunction-in-male-patients-with-pituitary-adenomas-a-multivariate-analysis
#5
Wen-Jian-Long Zhou, Shun-Chang Ma, Min Zhao, Chang Liu, Xiu-Dong Guan, Zhao-Shi Bao, Gui-Jun Jia, Wang Jia
The impact of sexual dysfunction (SD) is distressing to many male patients with pituitary adenomas which affect both physical and psychological health. The research explored to identify risk factors affecting sexual function and the prognosis of male patients with pituitary adenomas. Two hundred and fifty-four male patients, who aged between 18 and 60 (mean ± s.d.: 44.16 ± 10.14) years and diagnosed with pituitary adenomas, were retrospectively analyzed. One hundred and fifty-nine patients (62.6%) complained of SD prior to surgery...
August 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28814452/medical-ovariectomy-in-menopausal-breast-cancer-patients-with-high-testosterone-levels
#6
Giorgio Secreto, Paola Muti, Milena Sant, Elisabetta Meneghini, Vittorio Krogh
Five years of adjuvant therapy with anti-estrogens reduce the incidence of disease progression by about 50% in estrogen receptor-positive breast cancer patients, but late relapse can still occur after that anti-estrogens have been discontinued. In these patients, excessive androgen production may account for renewed excessive estrogen formation and increased risk of late relapse. In the 50% of patients who do not benefit with anti-estrogens, the effect of therapy is limited by de novo or acquired resistance to treatment...
August 16, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28809938/perinatal-testosterone-exposure-potentiates-vascular-dysfunction-by-er%C3%AE-suppression-in-endothelial-progenitor-cells
#7
Weiguo Xie, Mingming Ren, Ling Li, Yin Zhu, Zhigang Chu, Zhigang Zhu, Qiongfang Ruan, Wenting Lou, Haimou Zhang, Zhen Han, Xiaodong Huang, Wei Xiang, Tao Wang, Paul Yao
Recent clinical cohort study shows that testosterone therapy increases cardiovascular diseases in men with low testosterone levels, excessive circulating androgen levels may play a detrimental role in the vascular system, while the potential mechanism and effect of testosterone exposure on the vascular function in offspring is still unknown. Our preliminary results showed that perinatal testosterone exposure in mice induces estrogen receptor β (ERβ) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect...
2017: PloS One
https://www.readbyqxmd.com/read/28807505/delayed-ejaculation-and-associated-complaints-relationship-to-ejaculation-times-and-serum-testosterone-levels
#8
Abraham Morgentaler, Paula Polzer, Stanley Althof, Alexander Bolyakov, Craig Donatucci, Xiao Ni, Ankur B Patel, Shehzad Basaria
BACKGROUND: Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. AIM: To examine in an observational study estimated intravaginal ejaculatory latency time (IELT) and masturbatory ejaculation latency time (MELT) in men self-reporting DE, assess the association of IELT and MELT with serum testosterone levels, and determine whether correlation with demographic and sexual parameters exist...
August 11, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28804590/feminizing-adrenocortical-carcinoma-without-gynecomastia
#9
Farida Chentli, Fadila Chabour, Djafer Bouchibane, Nouria Nouar
Malignant feminizing adrenocortical tumors are exceedingly rare. Their main presentation is gynecomastia. In these estrogen secreting tumors (with or without other adrenocortical hormones) lack of gynecomastia is exceptional as in our case. A 44-year-old man presented with abdominal pain. Radiological assessment revealed a tumor measuring 120 × 95 mm in the retroperitoneal area with numerous metastases. Pathological examination pleaded for an adrenal origin with a Weiss's score of 5. Six months later, the tumor relapsed, and he had a second surgery and was sent for hormone assessment...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28802821/association-of-sex-hormones-with-metabolic-syndrome-among-egyptian-males
#10
Iman Z Ahmed, Maram M Mahdy, Hussein El Oraby
BACKGROUND: Studies have shown that testosterone and estradiol (E2) are associated with metabolic syndrome (MetS). To our knowledge, few studies, if any about the association of endogenous sex hormones with MetS have been done in Egypt. AIM: To study the relation between endogenous sex hormones and MetS among Egyptian males. SUBJECTS AND METHOD: For the study, 80 Egyptian males were enrolled: 40 males with MetS and 40 healthy age-matched males...
August 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28800500/sb223412-a-neurokinin-3-receptor-selective-antagonist-suppresses-testosterone-secretion-in-male-guinea-pigs
#11
Sho Nakamura, Yoshiko Ito, Koki Yamamoto, Chudai Takahashi, Mingdao Dai, Miyu Tanahashi, Yoshihisa Uenoyama, Hiroko Tsukamura, Shinya Oishi, Kei-Ichiro Maeda, Fuko Matsuda
Guinea pigs are important zoo animals and have been recommended for animal-assisted activities or therapy, however there are problems concerning testosterone inducing aggressive or sexual behaviors in male guinea pigs. Testicular testosterone secretion is regulated by pulsatile gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release in mammals. The mechanism generating GnRH/LH pulses is thought to be governed by kisspeptin neurons, which coexpress neurokinin B (NKB) and dynorphin A (Dyn), in the arcuate nucleus (ARC)...
July 31, 2017: Theriogenology
https://www.readbyqxmd.com/read/28799438/structural-evaluation-of-the-peritubular-sheath-of-rat-s-testes-after-administration-of-ribavirin-a-possible-impact-on-the-testicular-function
#12
Shaima M Almasry, Zeinab A Hassan, Wael M Elsaed, Yasser M Elbastawisy
Effects of ribavirin on the structure of peritubular sheath (PS) of seminiferous tubules and on testicular functions were studied. We found that ribavirin at a dose of 4 mg/kg/day for 4 weeks produced a significant reduction in testosterone level (6.3 ± 0.2; P < 0.001) and in spermatogenic score count (3.8 ± 0.2; P < 0.001) compared to control values. The thickness of PS (17.8 ± 1.13) and tubular lumen perimeter (1024.7 ± 67) was significantly increased compared to controls (10...
August 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28792252/rosa-damascena-mill-essential-oil-has-protective-effect-against-testicular-damage-in-diabetic-rats
#13
Somayeh Hamedi, Tahoora Shomali, Aliakbar Haghighat
This study investigates the protective effect of Rosa damascena essential oil on diabetes-induced testicular damage in rats. Thirty-six male Wistar rats were randomly divided into 6 equal groups: Group I: negative control (no treatment); Group II: positive control (diabetic by alloxan injection); Groups III-VI that rendered diabetic and received, respectively, 50, 100, 200, and 400 µg/kg/day rose oil, orally for 28 days. Rose oil did not significantly change body weight and blood glucose level as compared to positive control...
August 9, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28782904/role-of-olfactory-reactions-nociception-and-immunoendocrine-shifts-in-addictive-disorders
#14
Elena Masterova, Tatiana Nevidimova, Dariya Savochkina, Valentina Nikitina, Olga Lobacheva, Tamara Vetlugina, Nikolay Bokhan
BACKGROUND AND OBJECTIVES: Addictive pathology is associated with nervous, immune, and endocrine shifts. Meanwhile, the nature of intersystemic relationship lying beneath addictive disorders remains unclear. The purpose of the study was to identify neuroimmunoendocrine markers of addictive disorders in male subjects defining the nature of their interaction. METHODS: The study enrolled 69 subjects aged 18-43 years: 59 males and 10 females divided into those with addictive disorders (n = 39) and conditionally healthy subjects (n = 30)...
August 7, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28782738/trials-of-testosterone-replacement-reporting-cardiovascular-adverse-events
#15
Thiago Gagliano-Jucá, Shehzad Basaria
The numbers of testosterone prescriptions written have increased several-fold worldwide, but the incidence of pathological hypogonadism due to hypothalamic, pituitary, and testicular disease has remained unchanged. Most of these prescriptions are being dispensed to middle-aged and older men who have experienced age-related decline in serum testosterone levels; a subset of the population in which benefits of testosterone replacement is at best, modest. Recently, some randomized controlled trials have reported increased cardiovascular events in men (mainly older men and those with prevalent cardiovascular disease) with testosterone use, and a few recent meta-analyses have confirmed these findings...
August 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28777369/-obstructive-sleep-apnea-syndrome-and-age-related-hypohonadism
#16
I M Madaeva, O N Berdina, N V Semenova, V V Madaev, L V Rychkova, L I Kolesnikova
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a common disease that causes a different spectrum of life processes violations in the continuum of 'sleep-wakefulness'. OSAS in combination with age-specific hypogonadism as a systemic pathology requires certain interdisciplinary approaches involving both the correction of the obstruction, and testosterone therapy in men with hypogonadism. AIM: Assessment of the effect of combined use of CPAP (Continuous Positive Airway Pressure) and testosterone replacement therapy (transdermal form - Androgel) on indicators of polysomnography monitoring (PSG) with simultaneous study of erectile function and testosterone secretion...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28772110/leydig-cell-dysfunction-systemic-inflammation-and-metabolic-syndrome-in-long-term-testicular-cancer-survivors
#17
M Bandak, N Jørgensen, A Juul, J Lauritsen, P S Oturai, J Mortensen, P Hojman, J W Helge, G Daugaard
BACKGROUND: Twenty to thirty percent of testicular cancer (TC) survivors have elevated serum levels of luteinising hormone (LH) with or without corresponding low testosterone levels (Leydig cell dysfunction) during clinical follow-up for TC. However, it remains to be clarified if this subgroup of TC survivors has an increased long-term risk of systemic inflammation and metabolic syndrome (MetS) when compared with TC survivors with normal Leydig cell function during follow-up. PATIENTS AND METHODS: TC survivors with Leydig cell dysfunction and a control group of TC survivors with normal Leydig cell function during follow-up were eligible for participation in the study...
July 31, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28771887/acsl3-promotes-intratumoral-steroidogenesis-in-prostate-cancer-cells
#18
Toshiro Migita, Ken-Ichi Takayama, Tomohiko Urano, Daisuke Obinata, Kazutaka Ikeda, Tomoyoshi Soga, Satoru Takahashi, Satoshi Inoue
Long-chain acyl-coenzyme A (CoA) synthetase 3 (ACSL3) is an androgen-responsive gene involved in the generation of fatty acyl-CoA esters. ACSL3 is expressed in both androgen-sensitive and castration-resistant prostate cancer (CRPC). However, its role in prostate cancer remains elusive. We overexpressed ACSL3 in androgen-dependent LNCaP cells and examined the downstream effectors of ACSL3. Furthermore, we examined the role of ACSL3 in the androgen metabolism of prostate cancer. ACSL3 overexpression led to upregulation of several genes such as aldo-keto reductase 1C3 (AKR1C3) involved in steroidogenesis, which utilizes adrenal androgen dehydroepiandrosterone sulfate (DHEAS) as substrate, and downregulated androgen-inactivating enzyme UDP-glucuronosyltransferase 2 (UGT2B)...
August 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28771486/analysis-of-seminal-plasma-from-brown-bear-ursus-arctos-during-the-breeding-season-its-relationship-with-testosterone-levels
#19
L Anel-López, C Ortega-Ferrusola, C Martínez-Rodríguez, M Álvarez, S Borragán, C Chamorro, F J Peña, L Anel, P de Paz
Seminal plasma (SP) plays an important role in the motility, viability and maintenance of the fertilizing capacity of mammalian spermatozoa. This study is the first on brown bear (Ursus arctos) SP components, and has two main objectives: 1) to define the SP composition in bear ejaculate and 2) to identify variations in SP composition in relation to high and low levels of testosterone in serum during the breeding season. Forty-eight sperm samples from 30 sexually mature male brown bears (Ursus arctos) were obtained by electroejaculation, and their serum testosterone levels were assessed to sort the animals into 2 groups (high and low testosterone levels, threshold 5 ng/dl)...
2017: PloS One
https://www.readbyqxmd.com/read/28770683/plasma-testosterone-levels-increase-with-expression-of-male-ornaments-during-mating-but-not-incubation-in-japanese-barn-swallows
#20
Masaru Hasegawa, Emi Arai, Megumi Sato, Hidetsugu Sakai
Recent experimental studies involving the manipulation of sexual traits have demonstrated that sexual trait expression feeds back to testosterone levels, perhaps via social interactions, reinforcing the linkage between sexual trait expression and testosterone levels during the mating period. However, information on this reinforcement under the natural variation of sexual traits remains limited. Using Japanese barn swallows, Hirundo rustica gutturalis, in which extra-pair paternity is quite rare (< 3%), we studied the relationship between plasma testosterone level and a male sexual trait, throat patch size, during the mating and incubation periods...
August 2017: Zoological Science
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