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https://www.readbyqxmd.com/read/28721216/switch-to-restoration-therapy-in-a-testosterone-treated-central-hypogonadism-with-erythrocytosis
#1
B Cangiano, C Cacciatore, L Persani, M Bonomi
We describe a case of severe erythrocytosis caused by testosterone replacement therapy in a 66-year-old man affected with hypogonadotropic hypogonadism (HH) determining osteoporosis, resolved by switching to restoration therapy with clomiphene citrate. The patient complained fatigue, loss of libido and defective erections and a spontaneous vertebral fracture despite bisphosphonate therapy and vitamin D supplementation. The examinations proved isolated HH and he was therefore treated with testosterone gel with regression of specific manifestations but elevated hemoglobin and hematocrit values...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28721134/osteoporosis-in-men
#2
REVIEW
Waldemar Misiorowski
Osteoporotic fractures are the leading cause of morbidity and mortality among aging men. 30% of all hip fractures occur in men, and mortality resulting from not only the hip fracture, but also the spine and other major osteoporotic fractures, is significantly higher in men than in women. As in women, hypogonadism is the best documented risk factor for developing osteoporosis in men. In older men, testosterone levels are negatively correlated with the risk of fractures, and it seems that this age-related testosterone deficiency should not be considered as one of the many causes of secondary osteoporosis, rather one of the major and most important mechanisms of senile osteoporosis...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28721133/late-onset-hypogonadism
#3
REVIEW
Piotr Dudek, Jarosław Kozakowski, Wojciech Zgliczyński
In Poland, the number of men over the age of 50 years exceeds 6 million. It is estimated that about 2-6% of this population develops symptoms of late-onset hypogonadism (LOH). In men, testosterone deficiency increases slightly with age. LOH is a clinically and biochemically defined disease of older men with serum testosterone level below the reference parameters of younger healthy men and with symptoms of testosterone deficiency, manifested by pronounced disturbances of quality of life and harmful effects on multiple organ systems...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28717276/testosterone-versus-clomiphene-citrate-in-managing-symptoms-of-hypogonadism-in-men
#4
Pranav Dadhich, Ranjith Ramasamy, Jason Scovell, Nathan Wilken, Larry Lipshultz
INTRODUCTION: Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS: 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. These men were also compared to eugonadal men who were not on CC or TST during the same period...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28712786/the-relationship-between-hot-flashes-and-testosterone-recovery-after-12-months-of-androgen-suppression-for-men-with-localised-prostate-cancer-in-the-ascende-rt-trial
#5
M Dosani, W J Morris, S Tyldesley, T Pickles
AIMS: This study describes the proportion of men who experienced hot flashes (flashes), and the testosterone level at onset, peak frequency and cessation of flashes after 12 months of androgen deprivation therapy (ADT) in men undergoing curative-intent external beam radiation therapy (± brachytherapy boost). We also aimed to characterise testosterone recovery in this population. MATERIALS AND METHODS: This was a pre-specified secondary analysis of the ASCENDE-RT clinical trial...
July 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28712059/a-combination-of-testosterone-and-white-blood-cell-count-as-a-predictive-factor-of-overall-survival-in-localized-prostate-cancer
#6
Daniel Taussky, Denis Souliéres, Laurent Azoulay, Hui Yin, Houda Bahig, Jean-Paul Bahary, Guila Delouya
BACKGROUND: It has been shown that neutrophil count or an elevated neutrophil-to-lymphocyte ratio (NLR) as well as testosterone levels are separately associated with increased mortality in patients with localized prostate cancer. OBJECTIVE: We tested a combination of testosterone levels and white blood cell (WBC) counts to predict overall survival (OS) in a prospective cohort of patients treated with radiotherapy for localized prostate cancer. PATIENTS AND METHODS: The 381 patients included in this study were prospectively enrolled in phase 2 or 3 studies...
July 15, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28712040/the-effect-of-targeted-therapy-for-genitourinary-malignancies-on-sexual-function-and-fertility
#7
REVIEW
Bradley C Holland, Zubin Shetty, Shaheen Alanee
PURPOSE OF REVIEW: Targeted therapy for genitourinary cancer is being used at an increasing rate. These medications show great survival benefit but are relatively lacking in long-term adverse effect data. With increasing survivability, measures to improve quality of life must be considered for GU cancer and a large proponent of this is sexual function. RECENT FINDINGS: mTOR inhibitors have shown an effect on testosterone levels and may have a link to abnormal semen parameters...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28707057/application-of-testosterone-supplementation-in-semen-to-improve-sperm-motility-in-asthenozoospermic-males
#8
Isarin Thanaboonyawat, Panicha Chantrapanichkul, Somsin Petyim, Chidchanok Kaewjunun, Pitak Laokirkkiat, Roungsin Choavaratana
PURPOSE: To evaluate the effect of different concentrations and durations of seminal testosterone supplementation upon the motility of sperm from asthenozoospermic males. METHODS: Semen was collected from 41 infertile men with asthenozoospermia. After liquefaction, 200 μL was extracted from each semen sample and divided equally into five groups for a negative control, a vehicle control, and three experimental portions mixed with 4.75, 7.75, and 17.75 nmol/L of testosterone, respectively...
July 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28706413/virilization-in-a-postmenopausal-female-due-to-androgen-secreting-ovarian-dermoid-cyst
#9
Murali Subbaiah, Gowri Dorairajan, Debasis Gochhait, G Vijayalakshmi
Virilizing ovarian dermoid cysts are very rare. The source of androgen in these cysts may be tumors such as Sertoli-Leydig cell tumor or Leydig cell hyperplasia. A 52-year-old postmenopausal female with virilization was found to have an ovarian dermoid cyst on ultrasound. Her serum testosterone levels were elevated. Leydig cell hyperplasia within the dermoid cyst was found to be the source of androgen in this patient.
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28706184/testosterone-promotes-either-dominance-or-submissiveness-in-the-ultimatum-game-depending-on-players-social-rank
#10
Yukako Inoue, Taiki Takahashi, Robert P Burriss, Sakura Arai, Toshikazu Hasegawa, Toshio Yamagishi, Toko Kiyonari
Endogenous testosterone promotes behaviours intended to enhance social dominance. However, recent research suggests that testosterone enhances strategic social behaviour rather than dominance seeking behaviour. This possibility has not been tested in a population whose members are known to vary in social status. Here, we explored the relationship between pre-existing social status and salivary testosterone level among members of a rugby team at a Japanese university, where a strong seniority norm maintains hierarchical relationships...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705923/maternal-and-female-fetal-testosterone-levels-are-associated-with-maternal-age-and-gestational-weight-gain
#11
Theodora Kunovac-Kallak, Charlotte Hellgren, Alkistis Skalkidou, Lotta Sandelin-Francke, Kumari Ubhayasekera, Jonas Bergquist, Ove Axelsson, Erika Comasco, Rebecca Campbell, Inger Sundstrom Poromaa
OBJECTIVE: Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood, and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses...
July 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28704075/arecoline-cannot-alter-testicular-dysfunction-and-pineal-activation-caused-by-noise-in-wistar-rat
#12
Indraneel Saha, Aniruddha Chatterjee, Urmi Chatterji, B R Maiti
Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Noise exposure (100 dB, 6 h daily, 10 days) caused pineal stimulation ultrastructurally and at indoleamines level. Leydig cell dysfunction with fall of testosterone level and suppression of sex accessories were noticed...
July 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28699484/immune-response-to-native-lipoproteins-induces-visceral-obesity-and-aortic-wall-injury-in-rats-the-role-of-testosterone
#13
Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Marina Marina Anikaeva, Daria Suntsova, Alexandr Sidorov, Elena Stolyarova
OBJECTIVES: The underlying mechanism of atherosclerosis and visceral obesity remains unknown. The purpose of this study was to test the hypothesis that atherosclerosis and visceral obesity are caused by an immune response to native plasma lipoproteins, and the atherogenic and adipogenic effects of the antibodies to native lipoproteins stem from the androgen deficiency that is created. METHODS: Wistar rats were immunized with native human (nh) low-density (LDL) or high-density lipoproteins (HDL)...
July 11, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28698282/circulating-sex-steroids-co-regulate-adipose-tissue-immune-cell-populations-in-healthy-men
#14
Katya B Rubinow, Jing Chao, Derek Hagman, Mario Kratz, Brian Van Yserloo, Nilesh W Gaikwad, John K Amory, Stephanie T Page
Male hypogonadism results in changes in body composition characterized by increases in fat mass. Resident immune cells influence energy metabolism in adipose tissue and could promote increased adiposity through paracrine effects. We hypothesized that manipulation of circulating sex steroid levels in healthy men would alter adipose tissue immune cell populations. Subjects (n=44 men, 19-55 years of age) received 4 weeks of treatment with the GnRH receptor antagonist acyline with daily administration of 1) placebo gel, 2) 1...
July 11, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28695864/the-role-of-the-serum-testosterone-levels-as-a-predictor-of-prostate-cancer-in-patients-with-atypical-small-acinar-proliferation-at-the-first-prostate-biopsy
#15
Lucio Dell'Atti, Andrea B Galosi
The current literature does not support the usefulness of clinical markers on predicting which patients with atypical small acinar proliferation (ASAP) are more likely to progress to prostate cancer (PCa). Androgens have long been considered to be the potential risk factors for PCa. However, the role of testosterone is controversial. The present study aims to analyze the relationship between serum testosterone (TS) levels and the diagnosis of PCa after a first prostate biopsy in patients affected by ASAP. This retrospective study included 143 patients diagnosed with ASAP in an initial transrectal ultrasound-guided prostate biopsy for suspicious PCa according to the European Association of Urology guidelines...
July 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28693116/long-term-follow-up-of-a-child-with-klinefelter-syndrome-and-achondroplasia-from-infancy-to-16-years
#16
Jessica D Arditi, Loretta Thomaidis, Helen Frysira, Artemis Doulgeraki, George P Chrousos, Christina Kanaka-Gantenbein
BACKGROUND: Achondroplasia (ACH), an autosomal dominant skeletal dysplasia, occurs in approximately 1:20,000 births. On the other hand, 47,XXY aneuploidy (Klinefelter syndrome [KS]) is the most common sex chromosome disorder, with a prevalence of approximately 1:600 males. To the best of our knowledge, only five cases of patients presenting both ACH and KS have been reported to date in the international literature. However, none of these cases has been longitudinally followed during the entire childhood...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28692609/human-semen-quality-sperm-dna-damage-and-the-level-of-reproductive-hormones-in-relation-to-urinary-concentrations-of-parabens
#17
Joanna Jurewicz, Michał Radwan, Bartosz Wielgomas, Emila Dziewirska, Anetta Karwacka, Anna Klimowska, Paweł Kałużny, Paweł Radwan, Michał Bochenek, Wojciech Hanke
OBJECTIVE: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]. METHODS: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method...
July 7, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28690571/the-correlation-among-neural-dynamic-processing-of-conflict-control-testosterone-and-cortisol-levels-in-10-year-old-children
#18
Fangfang Shangguan, Tongran Liu, Xiuying Liu, Jiannong Shi
Cognitive control is related to goal-directed self-regulation abilities, which is fundamental for human development. Conflict control includes the neural processes of conflict monitoring and conflict resolution. Testosterone and cortisol are essential hormones for the development of cognitive functions. However, there are no studies that have investigated the correlation of these two hormones with conflict control in preadolescents. In this study, we aimed to explore whether testosterone, cortisol, and testosterone/cortisol ratio worked differently for preadolescent's conflict control processes in varied conflict control tasks...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28689186/acupuncture-attenuates-hyperglycaemia-and-improves-ovarian-function-in-female-rats-subjected-to-continuous-light-exposure
#19
Xuezhi Kang, Lina Jia, Yaming Li, Xu Zhang
OBJECTIVE: Exposure to unnatural light cycles is increasingly associated with obesity and the metabolic syndrome. The purpose of this study was to examine the effects of electroacupuncture (EA) on glucose metabolism and ovarian function in female rats subjected to long-term continuous light exposure. METHODS: Female Sprague-Dawley rats (n=24) were divided into three experimental groups: an LD group that was maintained under a normal light-dark cycle (healthy control); an LL group that was exposed to continuous light for 21 weeks but remained untreated; and an LL+EA group that received EA at ST36 and SP6 during weeks 17 to 21 of continuous light exposure...
July 8, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28682787/in-utero-virilization-secondary-to-a-maternal-krukenberg-tumor-case-report-and-review-of-literature
#20
Carmen Bustamante, Alfonso Hoyos-Martínez, Daniela Pirela, Alejandro Díaz
BACKGROUND: Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). High maternal androgens can cross the placenta producing virilization of the female fetus...
July 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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