keyword
MENU ▼
Read by QxMD icon Read
search

Maternal fetal

keyword
https://www.readbyqxmd.com/read/29353259/non-invasive-prenatal-testing-of-pregnancies-at-risk-for-phenylketonuria
#1
Huikun Duan, Ning Liu, Zhenhua Zhao, Yiqian Liu, Yin Wang, Zhifeng Li, Mengnan Xu, David S Cram, Xiangdong Kong
BACKGROUND: Phenylketonuria (PKU) is a common metabolic disorder caused predominately by mutations in the phenylalanine hydroxylase (PAH) gene. The aim of the study was to design and validate the performance of a non-invasive prenatal test (NIPT) for PKU using circulating single molecule amplification and resequencing technology (cSMART). METHODS: A total of 18 couples at genetic risk for having a child with PKU were recruited to the study. Gold standard invasive prenatal diagnosis (IPD) was performed on amniocyte or villus cell DNA by Sanger sequencing, targeting the known parental PAH mutations...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353134/knowledge-attitudes-and-practices-of-pregnant-women-in-martinique-in-the-immediate-aftermath-of-the-zika-virus-outbreak
#2
J Delet, A Cabié, S Merle, J-L Voluménie, A Monthieux
INTRODUCTION: The WHO and the HCSP recognize the Zika virus as a public health problem of international concern primarily because of the foetal risks. During the epidemic in Martinique, several modifications to the normal obstetrical follow-up were set up and information had to be delivered to pregnant women about these modifications, the attitudes to prevent infection and the signs motivating additional visits. The objective of our work was to evaluate the knowledge, attitudes and practices of pregnant women in Martinique about the risks associated with Zika infection during pregnancy in the immediate aftermath of the epidemic...
January 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29352601/regulating-needs-exploring-the-role-of-insulin-like-growth-factor-2-signalling-in-materno-fetal-resource-allocation
#3
Amanda Nancy Sferruzzi-Perri
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function...
January 11, 2018: Placenta
https://www.readbyqxmd.com/read/29352600/placental-control-of-metabolic-adaptations-in-the-mother-for-an-optimal-pregnancy-outcome-what-goes-wrong-in-gestational-diabetes
#4
David J Hill
As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are likely to exist, each also exerts indirect actions to ensure fetal nutritional availability through modulation of the maternal insulin/insulin-like growth factor axis. Peripheral insulin resistance results from the increasing levels of GH-V in the maternal circulation and is counter-balanced by an increase in insulin availability through an expansion of maternal pancreatic β-cell mass...
January 9, 2018: Placenta
https://www.readbyqxmd.com/read/29352147/pre-conception-maternal-erythrocyte-saturated-to-unsaturated-fatty-acid-ratio-predicts-pregnancy-after-natural-cycle-frozen-embryo-transfer
#5
Christopher C Onyiaodike, Heather M Murray, Ruiqi Zhang, Barbara J Meyer, Fiona Jordan, E Ann Brown, Robert J B Nibbs, Helen Lyall, Naveed Sattar, Scott M Nelson, Dilys J Freeman
The environment for embryo implantation and fetal growth and development is affected by maternal nutritional, metabolic and health status. The aim of this prospective, cohort study was to test whether plasma metabolic and inflammatory biomarkers can predict pregnancy resulting from in vitro fertilisation (IVF). Women with a natural menstrual cycle undergoing frozen embryo transfer (FET) were recruited and fasting baseline blood samples were collected a mean of 3.4 days prior to the luteinising hormone (LH) surge and a non-fasting blood sample was taken on the day of FET...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352068/maternal-fetal-disposition-and-metabolism-of-retrorsine-in-pregnant-rats
#6
Xia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng, Hui Wang
Pyrrolizidine alkaloids (PAs) are extensively synthesized by plants and are commonly present in herbs and foodstuffs, which exhibit hepatotoxicity requiring metabolic activation by cytochrome P450 (CYP) 3A to form the electrophilic metabolites-pyrrolic ester. PAs also cause embryo toxicity, but the metabolic profiles of PAs in fetus and placenta have been far from clear. In this study, we determined the basal metabolic activation of retrorsine (RTS) in rat maternal liver, placenta and fetal liver in vitro, and examined the fetal toxicity and bioactivation of RTS in vivo...
January 19, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29351561/preconception-use-of-cart-by-hiv-positive-pregnant-women-increases-the-risk-of-infants-being-born-small-for-gestational-age
#7
Ingrid J M Snijdewind, Colette Smit, Mieke H Godfried, Rachel Bakker, Jeannine F J B Nellen, Vincent W V Jaddoe, Elisabeth van Leeuwen, Peter Reiss, Eric A P Steegers, Marchina E van der Ende
BACKGROUND: The benefits of combination anti-retroviral therapy (cART) in HIV-positive pregnant women (improved maternal health and prevention of mother to child transmission [pMTCT]) currently outweigh the adverse effects due to cART. As the variety of cART increases, however, the question arises as to which type of cART is safest for pregnant women and women of childbearing age. We studied the effect of timing and exposure to different classes of cART on adverse birth outcomes in a large HIV cohort in the Netherlands...
2018: PloS One
https://www.readbyqxmd.com/read/29351483/prenatal-exposure-to-diesel-exhaust-pm2-5-causes-offspring-%C3%AE-cell-dysfunction-in-adulthood
#8
Minjie Chen, Shuai Liang, Xiaobo Qin, Li Zhang, Lianglin Qiu, Sufang Chen, Ziying Hu, Yanyi Xu, Wanjun Wang, Yuhao Zhang, Qi Cao, Zhekang Ying
BACKGROUND: Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure to ambient fine particulate matter (PM2.5) is associated with various fetal abnormalities, suggesting that it may program offspring's susceptibility to diabetes. In the present study, we therefore examined whether maternal exposure to diesel exhaust PM2.5 (DEP), one of the major sources of ambient PM2...
December 26, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351419/maternal-nutrient-restriction-in-guinea-pigs-as-an-animal-model-for-studying-growth-restricted-offspring-with-post-natal-catch-up-growth
#9
Catherine L Nevin, Evan Formosa, Yohei Maki, Brad Matushewski, Timothy R H Regnault, Bryan S Richardson
We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs with fetal growth restriction (FGR) on offspring body and organ weights, hypothesizing that FGR-MNR animals will show catch-up growth, but with organ-specific differences. Guinea pig sows were fed ad libitum (Control) or 70% of the control diet from 4 week`s pre-conception, switching to 90% at mid-pregnancy (MNR). Control newborns >95g (appropriate for gestational age or AGA, N=37) and MNR newborns <85g (FGR, N=37) were monitored until neonatal (~25 days) or adult (~110 days) necropsy...
January 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29350490/chronic-exposure-to-high-doses-of-selenium-in-the-first-trimester-of-pregnancy-case-report-and-brief-literature-review
#10
Luisa D'Oria, Massimo Apicella, Carmen De Luca, Angelo Licameli, Caterina Neri, Marcella Pellegrino, Daniela Simeone, Marco De Santis
BACKGROUND: Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE: A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestational week (g.w.) 7 to 12, due to a prescription error. The patient experienced nausea, vomiting, hand and foot paresthesia, followed by fatigue, loss of fingernails and hair...
January 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29350128/between-a-rock-a-bye-and-a-hard-place-mood-disorders-during-the-peripartum-period
#11
Michael Thomson, Verinder Sharma
Mood disorders including major depressive disorder and bipolar disorder are common during and after pregnancy. Timely identification and appropriate management of mood episodes is essential to maximize maternal well-being and minimize adverse outcomes. Failure to do so results in maternal suffering and impaired child bonding, and has the potential for devastating outcomes including suicide and infanticide. Women are routinely screened for unipolar depression during or after pregnancy but not for bipolar disorder, in spite of the fact that childbirth is associated with a major risk for onset or exacerbation of bipolar disorder...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29349843/pregnancy-after-bariatric-surgery-maternal-and-fetal-outcomes-of-39-pregnancies-and-a-literature-review
#12
Maria Manuel Costa, Sandra Belo, Pedro Souteiro, João S Neves, Daniela Magalhães, Rita B Silva, Sofia C Oliveira, Paula Freitas, Ana Varela, Joana Queirós, Davide Carvalho
AIM: We aimed to evaluate the impact of bariatric surgery (BS) on maternal and fetal outcomes. METHODS: A retrospective, descriptive, observational study of 39 pregnant women who underwent BS in our institution between 2010 and 2014 was carried out. A sample of women who became pregnant after BS was evaluated, based on data concerning pregnancy, childbirth, and newborns. RESULTS: Of the 1182 patients who underwent BS at our institution during the study period, 1016 (85...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29349772/does-the-use-of-diagnostic-technology-reduce-fetal-mortality
#13
Jostein Grytten, Irene Skau, Rune Sørensen, Anne Eskild
OBJECTIVE: To examine the effect that the introduction of new diagnostic technology in obstetric care has had on fetal death. DATA SOURCE: The Medical Birth Registry of Norway provided detailed medical information for approximately 1.2 million deliveries from 1967 to 1995. Information about diagnostic technology was collected directly from the maternity units, using a questionnaire. STUDY DESIGN: The data were analyzed using a hospital fixed-effects regression with fetal mortality as the outcome measure...
January 19, 2018: Health Services Research
https://www.readbyqxmd.com/read/29349587/the-danish-medical-birth-register
#14
REVIEW
Mette Bliddal, Anne Broe, Anton Pottegård, Jørn Olsen, Jens Langhoff-Roos
The Danish Medical Birth Register was established in 1973. It is a key component of the Danish health information system. The register enables monitoring of the health of pregnant women and their offspring, it provides data for quality assessment of the perinatal care in Denmark, and it is used extensively for research. The register underwent major changes in construction and content in 1997, and new variables have been added during the last 20 years. The aim was to provide an updated description of the register focusing on structure, content, and coverage since 1997...
January 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29348623/fetal-vitamin-d-concentration-and-growth-adiposity-and-neurodevelopment-during-infancy
#15
H Wang, X D Yu, L S Huang, Q Chen, F X Ouyang, X Wang, J Zhang
BACKGROUND/OBJECTIVES: To determine the association between cord blood 25-hydroxyvitamin D (25(OH)D) concentration with growth, adiposity and neurodevelopment during infancy. SUBJECTS/METHODS: Serum 25(OH)D was measured in cord blood by the liquid chromatography tandem mass spectrometry (LC-MS/MS) from the Shanghai's "Allergy and Obesity Cohort study" (n = 1244). Weight, length, head circumference, and body mass index (BMI) z-scores for age were calculated based on World Health Organization Standard (at 6 months, 1 years, and 2 years)...
January 18, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29348260/the-canadian-preterm-birth-network-a-study-protocol-for-improving-outcomes-for-preterm-infants-and-their-families
#16
Prakesh S Shah, Sarah D McDonald, Jon Barrett, Anne Synnes, Kate Robson, Jonathan Foster, Jean-Charles Pasquier, K S Joseph, Bruno Piedboeuf, Thierry Lacaze-Masmonteil, Karel O'Brien, Sandesh Shivananda, Nils Chaillet, Petros Pechlivanoglou
BACKGROUND: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. METHODS: Our national cohort will include 24 maternal-fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29347926/handheld-ultrasound-to-avert-maternal-and-neonatal-deaths-in-2-regions-of-the-philippines-an-ibuntis%C3%A2-intervention-study
#17
Godofreda V Dalmacion, Ramon T Reyles, Antonia E Habana, Lalaine Mae V Cruz, Maricelle C Chua, Analyn T Ngo, Milagros J Tia-Jocson, Emmanuel S Baja
BACKGROUND: The major causes of maternal and neonatal mortality in the Philippines are hemorrhages and obstructed labor due to placental implantation abnormalities (PIAs), twin pregnancies and fetal malpresentations. All of which are all easily detected by ultrasound. However, women in rural areas and low-income groups do not have access to ultrasound during their prenatal care. We aimed to provide additional evidence on the benefits of handheld ultrasound (HU) for screening pregnancy related abnormalities in order to avert maternal and neonatal deaths...
January 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29345098/influence-of-maternal-obesity-on-fetal-growth-at-different-periods-of-pregnancies-with-normal-glucose-tolerance
#18
Kei Tanaka, Miho Matsushima, Tomoko Izawa, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
AIM: We aimed to examine the influence of maternal obesity on fetal growth in utero at different periods of pregnancies with normal glucose tolerance. METHODS: A retrospective cohort study on 356 pregnant women with normal glucose tolerance was conducted. The women were categorized by pre-pregnancy body mass index (BMI) as obese (OB; BMI ≥ 25.0 kg/m2 ) or non-obese (n-OB). Z-scores of the fetal abdominal circumference (AC) and the rate of fetal macrosomia (AC ≥ 90th percentile) at 19, 30, and 36 gestational weeks (GW) were compared between the two groups...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29344930/maternal-prenatal-stress-and-infant-dna-methylation-a-systematic-review
#19
REVIEW
David W Sosnowski, Carolyn Booth, Timothy P York, Ananda B Amstadter, Wendy Kliewer
Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as a candidate mechanism through which maternal prenatal stress can influence fetal HPA axis functioning. The goal of this systematic review was to summarize the literature examining the associations among maternal prenatal stress, DNA methylation of commonly studied HPA axis candidate genes, and infant HPA axis functioning...
January 18, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29343868/galectin-13-a-different-prototype-galectin-does-not-bind-%C3%AE-galacto-sides-and-forms-dimers-via-intermolecular-disulfide-bridges-between-cys-136-and-cys-138
#20
Jiyong Su, Yue Wang, Yunlong Si, Jin Gao, Chenyang Song, Linlin Cui, Runjie Wu, Guihua Tai, Yifa Zhou
During pregnancy, placental protein-13 (galectin-13) is highly expressed in the placenta and fetal tissue, and less so in maternal serum that is related to pre-eclampsia. To understand galectin-13 function at the molecular level, we solved its crystal structure and discovered that its dimer is stabilized by two disulfide bridges between Cys136 and Cys138 and six hydrogen bonds involving Val135, Val137, and Gln139. Native PAGE and gel filtration demonstrate that this is not a crystallization artifact because dimers also form in solution...
January 17, 2018: Scientific Reports
keyword
keyword
11599
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"