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Maternal fetal

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https://www.readbyqxmd.com/read/29778069/differential-correlations-between-maternal-hair-levels-of-tobacco-and-alcohol-with-fetal-growth-restriction-clinical-subtypes
#1
Sally Sabra, Ebba Malmqvist, Laura Almeida, Eduard Gratacos, Maria Dolores Gomez Roig
Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Therefore, a case-control study was conducted in Barcelona, Spain...
January 4, 2018: Alcohol
https://www.readbyqxmd.com/read/29777348/the-effect-of-labor-epidural-analgesia-on-maternal-fetal-outcomes-a-retrospective-cohort-study
#2
Qian Wang, Sheng-Xing Zheng, Yu-Fei Ni, Yuan-Yuan Lu, Bing Zhang, Qing-Quan Lian, Ming-Pin Hu
PURPOSE: To evaluate the impact of labor epidural analgesia on maternal-fetal safety outcomes in a signal Chinese academic medical center. METHODS: A single-intervention impact study was conducted at The Second Affiliated Hospital, Wenzhou Medical University. The study period was divided into three phases: (1) baseline phase: from January 1 and June 30, 2009 when no analgesic method was routinely employed during labor; (2) phase-in period: the epidural analgesia was implemented 8 a...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29776967/multicentre-study-of-maternal-and-neonatal-outcomes-in-individuals-with-prader-willi-syndrome
#3
Preeti Singh, Ranim Mahmoud, June-Anne Gold, Jennifer L Miller, Elizabeth Roof, Roy Tamura, Elisabeth Dykens, Merlin G Butler, Dan J Driscoll, Virginia Kimonis
INTRODUCTION: Prader-Willi syndrome (PWS) is a complex genetic disorder associated with three different genetic subtypes: deletion of the paternal copy of 15q11-q13, maternal UPD for chromosome 15 and imprinting defect. Patients are typically diagnosed because of neonatal hypotonia, dysmorphism and feeding difficulties; however, data on the prenatal features of PWS are limited. OBJECTIVE: The aim of the study was to identify and compare frequencies of prenatal and neonatal clinical features of PWS among the three genetic subtypes...
May 18, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#4
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29775414/venoarterial-communication-mediates-arterial-wall-shear-stress-induced-maternal-uterine-vascular-remodeling-during-pregnancy
#5
Nga Ling Ko, Liam John, Aaron Gelinne, Maurizio Mandala, George Osol
Although expansive remodeling of the maternal uterine circulation during pregnancy is essential for maintaining uteroplacental perfusion and normal fetal growth, the underlying physiological mechanisms are not well understood. Using a rat model, surgical approaches were used to alter uterine hemodynamics and wall shear stress (WSS) in order to evaluate the effects of WSS and venoarterial communication (e.g. transfer of placentally derived growth signals from post-placental veins to pre-placental arteries) on gestational uterine vascular remodeling...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29774647/effect-of-the-fetal-movement-count-on-maternal-fetal-attachment
#6
Esra Güney, Tuba Uçar
AIM: This study aimed to determine the effect of fetal movement counting on maternal-fetal attachment. METHODS: This study was a randomized controlled trial, conducted with experimental and control groups, each including 55 pregnant women from six family health centers in the Malatya Province, located in the east of Turkey. The data were collected by using a Personal Information Form and the Maternal Antenatal Attachment Scale. Training for fetal movement counting was provided to the experimental group...
May 17, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29774596/epidemiological-analysis-of-maternal-lipid-levels-during-the-second-trimester-in-pregnancy-and-the-risk-of-adverse-pregnancy-outcome-adjusted-by-pregnancy-bmi
#7
Chao-Yan Yue, Chun-Mei Ying
BACKGROUND: Pregnancy is accompanied by profound changes in lipid metabolism. We aimed to assess whether effects of second trimester body mass index and maternal lipid concentrations are associated with an increased risk of adverse pregnancy outcomes. METHODS: We investigated the serum levels of maternal lipids during the second trimester in pregnancy, and analyzed associations between the lipid levels and the risk of adverse pregnancy outcome. Seven hundred and seventy-four pregnant women were enrolled in this study between February 2016 and June 2016...
May 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#8
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#9
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#10
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29773978/effects-of-sevoflurane-exposure-during-mid-pregnancy-on-learning-and-memory-in-offspring-rats-beneficial-effects-of-maternal-exercise
#11
Ziyi Wu, Xingyue Li, Yi Zhang, Dongyi Tong, Lili Wang, Ping Zhao
Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29773943/retrospective-review-of-maternal-and-fetal-outcomes-in-patients-with-gestational-diabetes-mellitus-in-an-indigent-prenatal-clinic
#12
Sara W Reece, Harish S Parihar, Mark Martinez
No abstract text is available yet for this article.
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29772265/administration-of-low-dose-triclosan-to-pregnant-ewes-results-in-placental-uptake-and-reduced-estradiol-sulfotransferase-activity-in-fetal-liver-and-placenta
#13
Erin N Jackson, Laura Rowland-Faux, Margaret O James, Charles E Wood
Sulfonation is a major pathway of estrogen biotransformation with a role in regulating estrogen homeostasis in humans and sheep. Previous in vitro studies found that triclosan is an especially potent competitive inhibitor of ovine placental estrogen sulfotransferase, with Kic of <0.1 nM. As the placenta is the main organ responsible for estrogen synthesis in pregnancy in both women and sheep, and the liver is another site of estrogen biotransformation, this study examined the effects of triclosan exposure of pregnant ewes on placental and hepatic sulfotransferase activity...
May 14, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29772225/maternal-one-carbon-metabolism-through-increased-oxidative-stress-and-disturbed-angiogenesis-can-influence-placental-apoptosis-in-preeclampsia
#14
REVIEW
Vaishali V Kasture, Deepali P Sundrani, Sadhana R Joshi
Adequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12 ) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women with preeclampsia. Homocysteine is known to be involved in the formation of free radicals leading to increased oxidative stress...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29772083/effects-of-prenatal-stress-on-anxiety-and-depressive-like-behaviors-are-sex-specific-in-prepubertal-rats
#15
Ann Mary Iturra-Mena, Marcia Arriagada-Solimano, Ariane Luttecke-Anders, Alexies Dagnino-Subiabre
The fetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of stress on physiology and behavior. The aim of this study was to determine the physiological and behavioral effects of prenatal stress during the prepubertal period of female and male rats. We subjected pregnant Sprague-Dawley rats to a restraint stress protocol from gestational day 14 until 21, a critical period for fetal brain susceptibility to stress effects. Male and female offspring were subsequently assessed at postnatal day 24 for anxiety- and depressive-like behaviors, and spontaneous social interaction...
May 17, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29772054/oxycodone-pharmacokinetics-and-fetal-exposure-after-intravenous-or-epidural-administration-to-the-ewe
#16
Mari Kinnunen, Hannu Kokki, Heidi Hautajärvi, Heikki Huhta, Veli-Pekka Ranta, Juha Räsänen, Hanna-Marja Voipio, Merja Kokki
INTRODUCTION: There are limited data of oxycodone pharmacokinetics during pregnancy and on fetal exposure after maternal administration. The present study describes the pharmacokinetics of intravenous oxycodone in pregnant sheep and fetal exposure after intravenous and epidural administration. MATERIAL AND METHODS: 10 pregnant sheep received 0.1 mg·kg-1 oxycodone intravenously -bolus, and blood samples were collected up to 24 hours. Seven days later, the ewes were randomized to receive 0...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29771989/bacterial-dna-is-present-in-the-fetal-intestine-and-overlaps-with-that-in-the-placenta-in-mice
#17
Keith A Martinez, Joann Romano-Keeler, Joseph P Zackular, Daniel J Moore, Robert M Brucker, Christopher Hooper, Shufang Meng, Naoko Brown, Simon Mallal, Jeff Reese, David M Aronoff, Hakdong Shin, Maria Gloria Dominguez-Bello, Jörn-Hendrik Weitkamp
Bacterial DNA has been reported in the placenta and amniotic fluid by several independent groups of investigators. However, it's taxonomic overlap with fetal and maternal bacterial DNA in different sites has been poorly characterized. Here, we determined the presence of bacterial DNA in the intestines and placentas of fetal mice at gestational day 17 (n = 13). These were compared to newborn intestines (n = 15), maternal sites (mouth, n = 6; vagina, n = 6; colon, n = 7; feces, n = 8), and negative controls to rule out contamination...
2018: PloS One
https://www.readbyqxmd.com/read/29771920/maternal-human-telomerase-reverse-transcriptase-variants-are-associated-with-preterm-labor-and-preterm-premature-rupture-of-membranes
#18
Caroline Marrs, Kevin Chesmore, Ramkumar Menon, Scott Williams
OBJECTIVE: Premature aging and short telomere lengths of fetal tissues are associated with spontaneous preterm labor (PTL) and preterm premature rupture of membranes (pPROM). Maintenance of telomere length is performed by the enzyme telomerase. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase, and its dysfunction affects telomere shortening. This study assessed whether maternal or fetal genetic variations in the hTERT gene are associated with PTL or pPROM. METHODS: A case (PTL or pPROM) control (term birth) genetic association study was conducted in 654 non-Hispanic white mothers (438 term, 162 PTL, 54 pPROM) and 502 non-Hispanic white newborns (346 term, 116 PTB, 40 pPROM)...
2018: PloS One
https://www.readbyqxmd.com/read/29770967/developmental-programming-of-renal-function-nephron-endowment-and-beyond
#19
Andrew G Woodman, Stephane L Bourque
In the face of adversity, the fetal kidney doesn't fare well. When resources are limiting due to pregnancy complications such as placental insufficiency, maternal hypoxia, or nutrient deficiencies, kidney development is often compromised, showing signs of reduced growth, defective nephrogenesis, and abnormal morphology. This article is protected by copyright. All rights reserved.
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29770761/low-birth-weight-is-associated-with-increased-fat-intake-in-school-aged-boys
#20
Adrianne R Bischoff, André K Portella, Catherine Paquet, Roberta Dalle Molle, Aida Faber, Narendra Arora, Robert D Levitan, Patrícia P Silveira, Laurette Dube
Evidence suggests that both high and low birth weight children have increased the risk for obesity and the metabolic syndrome in adulthood. Previously we have found altered feeding behaviour and food preferences in pre-school children and adults born with low birth weight. In this study, we investigated if birth weight was associated with different intake of fat, carbohydrate and/or protein at 6-12 years of age. This is a cross-sectional study where 255 guardians answered online and telephone questions including anthropometrics and demographic data, parental family food rules (food control, encouragement and restriction) and a complete web-based FFQ for their children (130 boys and 125 girls)...
June 2018: British Journal of Nutrition
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