Shilpi Jain, Sanjeev Kumar, Lilin Lai, Susanne Linderman, Ansa A Malik, Madison L Ellis, Sucheta Godbole, Daniel Solis, Malaya K Sahoo, Kareem Bechnak, Isabel Paredes, Ralph Tanios, Bahaa Kazzi, Serena M Dib, Matthew B Litvack, Sonia T Wimalasena, Caroline Ciric, Christina Rostad, Richard West, I-Ting Teng, Danyi Wang, Sri Edupuganti, Peter D Kwong, Nadine Rouphael, Benjamin A Pinsky, Daniel C Douek, Jens Wrammert, Alberto Moreno, Mehul S Suthar
The rapid emergence of divergent SARS-CoV-2 variants has led to an update of the COVID-19 booster vaccine to a monovalent version containing the XBB.1.5 spike. To determine the neutralization breadth following booster immunization, we collected blood samples from 24 individuals pre- and post-XBB.1.5 mRNA booster vaccination (∼1 month). The XBB.1.5 booster improved both neutralizing activity against the ancestral SARS-CoV-2 strain (WA1) and the circulating Omicron variants, including EG.5.1, HK.3, HV...
February 5, 2024: bioRxiv