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Relational binding and memory

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https://www.readbyqxmd.com/read/29783061/enhanced-extinction-of-aversive-memories-in-mice-lacking-sparc-related-protein-containing-immunoglobulin-domains-1-spig1-fstl4
#1
Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Noda
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity related to learning and memory. We previously reported that SPARC-related protein-containing immunoglobulin domains 1 (SPIG1, also known as Follistatin-like protein 4, FSTL4) binds to pro-BDNF and negatively regulates BDNF maturation; however, its neurological functions, particularly in learning and memory, have not yet been elucidated. We herein examined the electrophysiological and behavioral phenotypes of Spig1-knockout (Spig1-KO) mice...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29775775/knowledge-and-learning-of-verb-biases-in-amnesia
#2
Rachel Ryskin, Zhenghan Qi, Natalie V Covington, Melissa Duff, Sarah Brown-Schmidt
Verb bias-the co-occurrence frequencies between a verb and the syntactic structures it may appear with-is a critical and reliable linguistic cue for online sentence processing. In particular, listeners use this information to disambiguate sentences with multiple potential syntactic parses (e.g., Feel the frog with the feather.). Further, listeners dynamically update their representations of specific verbs in the face of new evidence about verb-structure co-occurrence. Yet, little is known about the biological memory systems that support the use and dynamic updating of verb bias...
May 15, 2018: Brain and Language
https://www.readbyqxmd.com/read/29759084/sex-differences-in-associations-between-maternal-deprivation-and-alterations-in-hippocampal-calcium-binding-proteins-and-cognitive-functions-in-rats
#3
Hongyu Xu, Yuqin Ye, Yelu Hao, Fei Shi, Zhiqiang Yan, Guohao Yuan, Yuefan Yang, Zhou Fei, Xiaosheng He
BACKGROUND AND OBJECTIVE: Adverse early-life experiences have been suggested as one of the key contributors to neurodevelopmental disorders, such that these experiences influence brain development, cognitive ability and mental health. Previous studies indicated that hippocampal levels of the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) changed in response to maternal deprivation (MD), a model for adverse early-life experiences. We investigated the effects of MD on hippocampal CALR and CALB protein levels and cognitive behaviors, and explored whether these effects were sex-related...
May 15, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29756805/age-related-changes-in-working-memory-age-affects-relational-but-not-conjunctive-feature-binding
#4
Alexander Kirmsse, Hubert D Zimmer, Ullrich K H Ecker
In contrast to long-term memory, age-related association deficits in working memory are found only inconsistently. The authors hypothesized that type of binding is critical for the occurrence of such deficits. Relational binding abilities (associating separate visual units) should degrade with age, whereas more automatic conjunctive binding abilities (associating features within an object) should not. They contrasted associative memory and item memory using a change-detection task with colors and shapes in younger (18-33 years) and older (64-82 years) healthy adults...
May 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29746297/microglial-activation-is-inversely-associated-with-cognition-in-individuals-living-with-hiv-on-effective-antiretroviral-therapy
#5
Leah H Rubin, Ned Sacktor, Jason Creighton, Yong Du, Christopher J Endres, Martin G Pomper, Jennifer M Coughlin
OBJECTIVE: Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signaling by cells of the myeloid-lineage. Here we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g., frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function. DESIGN: 21 HIV+VS individuals underwent positron emission tomography (PET) with [C]DPA-713 to image the translocator protein 18 KDa (TSPO), a marker of microglial activation, and completed a comprehensive neuropsychological test battery...
May 9, 2018: AIDS
https://www.readbyqxmd.com/read/29741891/a-c-estrogens-as-potent-and-selective-estrogen-receptor-beta-agonists-serbas-to-enhance-memory-consolidation-under-low-estrogen-conditions
#6
Alicia M Hanson, K L Iresha Sampathi Perera, Jaekyoon Kim, Rajesh K Pandey, Noreena Sweeney, Xingyun Lu, Andrea Imhoff, Alexander Craig Mackinnon, Adam J Wargolet, Rochelle M Van Hart, Karyn M Frick, William A Donaldson, Daniel S Sem
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in post-menopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A-C estrogens, lacking the B and D estrogen rings. The most potent and selective A-C estrogen is selective for activating ER relative to seven other nuclear hormone receptors, with a surprising 750-fold selectivity for the beta over alpha isoform, and with EC50's of 20-30 nM in cell-based and direct binding assays...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29739861/molecular-biomarkers-of-alzheimer-s-disease-progress-and-prospects
#7
REVIEW
Tammaryn Lashley, Jonathan M Schott, Philip Weston, Christina E Murray, Henny Wellington, Ashvini Keshavan, Sandrine C Foti, Martha Foiani, Jamie Toombs, Jonathan D Rohrer, Amanda Heslegrave, Henrik Zetterberg
The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressive memory deficits. Clinically, these pathological changes can be detected in the cerebrospinal fluid and with brain imaging, although reliable blood tests for plaque and tangle pathologies remain to be developed. Plaques and tangles often co-exist with other brain pathologies, including aggregates of transactive response DNA-binding protein 43 and Lewy bodies, but the extent to which these contribute to the severity of Alzheimer's disease is currently unknown...
May 8, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29738701/flavones-bound-in-benzodiazepine-site-on-gaba-a-receptor-concomitant-anxiolytic-like-and-cognitive-enhancing-effects-produced-by-isovitexin-and-6-cglycoside-diosmetin
#8
Daniela Rodrigues de Oliveira, Andréia Hatsue Todo, Gizelda Maia Rêgo, Janete Maria Cerutti, Alberto José Cavalheiro, Daniela Gonçales Galasse Rando, Suzete Maria Cerutti
Increasing evidence suggests that flavones can modulate memory and anxiety-like behaviour. However, these therapeutic effects are inconsistent and induce of adverse effects, which have been associated with interactions at the Benzodiazepine (BZ)-binding site. To improve our understanding of flavone effects on memory and anxiety, we employed a plus-maze discriminative avoidance task. Furthermore, we evaluated the potential of the compounds in modulating GABAA receptors via BZ-binding site using molecular modelling studies...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29736736/the-medial-septum-is-insulin-resistant-in-the-ad-presymptomatic-phase-rescue-by-nerve-growth-factor-driven-irs-1-activation
#9
Valentina Sposato, Nadia Canu, Elena Fico, Salvatore Fusco, Giulia Bolasco, Maria Teresa Ciotti, Matteo Spinelli, Delio Mercanti, Claudio Grassi, Viviana Triaca, Pietro Calissano
Basal forebrain cholinergic neurons (BFCN) are key modulators of learning and memory and are high energy-demanding neurons. Impaired neuronal metabolism and reduced insulin signaling, known as insulin resistance, has been reported in the early phase of Alzheimer's disease (AD), which has been suggested to be "Type 3 Diabetes." We hypothesized that BFCN may develop insulin resistance and their consequent failure represents one of the earliest event in AD. We found that a condition reminiscent of insulin resistance occurs in the medial septum of 3 months old 3×Tg-AD mice, reported to develop typical AD histopathology and cognitive deficits in adulthood...
May 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29728647/opiate-associated-contextual-memory-formation-and-retrieval-are-differentially-modulated-by-dopamine-d1-and-d2-signaling-in-hippocampal-prefrontal-connectivity
#10
Yunpeng Wang, Hongying Zhang, Jingjing Cui, Jing Zhang, Fangyuan Yin, Hao Guo, Jianghua Lai, Bo Xing
Contextual memory driven by abused drugs such as opiates has a central role in maintenance and relapse of drug-taking behaviors. Although dopamine (DA) signaling favors memory storage and retrieval via regulation of hippocampal-prefrontal connectivity, its role in modulating opiate-associated contextual memory is largely unknown. Here, we report roles of DA signaling within the hippocampal-prefrontal circuit for opiate-related memories. Combining-conditioned place preference (CPP) with molecular analyses, we investigated the DA D1 receptor (D1R) and extracellular signal-regulated kinase (ERK)-cAMP-response element binding protein (CREB) signaling, as well as DA D2 receptor (D2R) and protein kinase B (PKB or Akt)/glycogen synthase kinase 3 (GSK3) signaling in the ventral hippocampus (vHip) and medial prefrontal cortex (mPFC) during the formation of opiate-related associative memories...
April 17, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29724824/distinctive-phosphoinositide-and-ca-2-binding-properties-of-normal-and-cognitive-performance-linked-variant-forms-of-kibra-c2-domain
#11
Mareike G Posner, Abhishek Upadhyay, Rieko Ishima, Antreas C Kalli, Gemma Harris, Joachim Kremerskothen, Mark S P Sansom, Susan J Crennell, Stefan Bagby
KIBRA, a multi-functional scaffold protein with around twenty known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking. KIBRA includes tandem N-terminal WW domains, a C2 domain and motifs for binding aPKC and PDZ domains. A naturally occurring human KIBRA variant involving residue changes at positions 734 (M-to-I) and 735 (S-to-A) within the C2 domain affects cognitive performance. We have elucidated 3D structures, and calcium and phosphoinositide binding properties, of human KIBRA C2 domain...
May 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29720691/the-behavioral-and-neural-binding-phenomena-during-visuomotor-integration-of-angry-facial-expressions
#12
Sélim Yahia Coll, Leonardo Ceravolo, Sascha Frühholz, Didier Grandjean
Different parts of our brain code the perceptual features and actions related to an object, causing a binding problem, in which the brain has to integrate information related to an event without any interference regarding the features and actions involved in other concurrently processed events. Using a paradigm similar to Hommel, who revealed perception-action bindings, we showed that emotion could bind with motor actions when relevant, and in specific conditions, irrelevant for the task. By adapting our protocol to a functional Magnetic Resonance Imaging paradigm we investigated, in the present study, the neural bases of the emotion-action binding with task-relevant angry faces...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29712785/remote-memory-and-cortical-synaptic-plasticity-require-neuronal-ccctc-binding-factor-ctcf
#13
Somi Kim, Nam-Kyung Yu, Kyu-Won Shim, Ji-Il Kim, Hyopil Kim, Dae Hee Han, Ja Eun Choi, Seung-Woo Lee, Dong Il Choi, Myung Won Kim, Dong-Sung Lee, Kyungmin Lee, Niels Galjart, Yong-Seok Lee, Jae-Hyung Lee, Bong-Kiun Kaang
The molecular mechanism of long-term memory has been extensively studied in the context of the hippocampus-dependent recent memory examined within several days. However, months-old remote memory maintained in the cortex for long-term has not been investigated much at the molecular level yet. Various epigenetic mechanisms are known to be important for long-term memory, but how the three-dimensional (3D) chromatin architecture and its regulator molecules contribute to neuronal plasticity and systems consolidation are still largely unknown...
April 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29710809/anti-oxidant-and-anti-inflammatory-activity-of-ketogenic-diet-new-perspectives-for-neuroprotection-in-alzheimer-s-disease
#14
REVIEW
Alessandro Pinto, Alessio Bonucci, Elisa Maggi, Mariangela Corsi, Rita Businaro
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease. The main activity of the ketogenic diet has been related to improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD⁺/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins...
April 28, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29704550/tau-hyperphosphorylation-and-p-creb-reduction-are-involved-in-acrylamide-induced-spatial-memory-impairment-suppression-by-curcumin
#15
Dandan Yan, Jianling Yao, Ying Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan
Acrylamide (ACR) is an axonal toxicant that produces peripheral neuropathy in laboratory animals and humans. Epidemiological study found that diet ACR exposure was associated with a mild cognitive decline in men. However, limited information is available as regards its potential and underlying mechanism to cause memory alterations. Curcumin is a polyphenol with neuroprotective and cognitive-enhancing properties. In this study, we aimed to investigate the mechanism of ACR-induced spatial memory impairment and the beneficial effect of curcumin...
April 26, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29703774/-11-c-pk11195-binding-in-alzheimer-disease-and-progressive-supranuclear-palsy
#16
Luca Passamonti, Patricia Vázquez Rodríguez, Young T Hong, Kieren S J Allinson, W Richard Bevan-Jones, David Williamson, P Simon Jones, Robert Arnold, Robin J Borchert, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
OBJECTIVE: We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). METHODS: Sixteen patients with symptomatic AD (including amnestic mild cognitive impairment with amyloid-positive PET scan), 16 patients with PSP-Richardson syndrome, and 13 age-, sex-, and education-matched healthy controls were included in this case-control study. Participants underwent [11 C]PK11195 PET scanning, which was used as an in vivo index of neuroinflammation...
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29695600/brain-pathology-is-related-to-total-daily-physical-activity-in-older-adults
#17
Aron S Buchman, Robert J Dawe, Lei Yu, Andrew Lim, Robert S Wilson, Julie A Schneider, David A Bennett
OBJECTIVE: To test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults. METHODS: We studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with actigraphy (Actical; Philips Healthcare, Bend, OR). Multiple regression analyses controlling for age and sex were used to examine the relation of brain indexes to total daily physical activity and other clinical covariates proximate to death...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29690543/memory-function-in-feeding-habit-transformation-of-mandarin-fish-siniperca-chuatsi
#18
Yaqi Dou, Shan He, Xu-Fang Liang, Wenjing Cai, Jie Wang, Linjie Shi, Jiao Li
Mandarin fish refuse dead prey fish or artificial diets and can be trained to transform their inborn feeding habit. To investigate the effect of memory on feeding habit transformation, we compared the reaction time to dead prey fish and the success rate of feeding habit transformation to dead prey fish with training of mandarin fish in the 1st experimental group (trained once) and the 2nd experimental group (trained twice). The mandarin fish in the 2nd group had higher success rate of feeding habit transformation (100%) than those in the 1st group (67%), and shorter reaction time to dead prey fish (<1 s) than those in the 1st group (>1 s)...
April 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29687202/attenuation-of-aluminum-chloride-induced-neuroinflammation-and-caspase-activation-through-the-akt-gsk-3%C3%AE-pathway-by-hesperidin-in-wistar-rats
#19
Arokiasamy Justin-Thenmozhi, Mathiyazahan Dhivya Bharathi, Ramaraj Kiruthika, Thamilarasan Manivasagam, Anupom Borah, Musthafa Mohamed Essa
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3 )-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3 -induced inflammation, caspase activation, Tau pathology, altered Akt/GSK 3β signaling pathway, and Aβ clearance marker has not yet been fully elucidated...
April 23, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29675706/audiomotor-integration-of-angry-and-happy-prosodies
#20
Sélim Yahia Coll, Sascha Frühholz, Didier Grandjean
Different parts of our brain code the perceptual features and actions related to an object, causing a binding problem: how does the brain discriminate the information of a particular event from the features of other events? Hommel (1998) suggested the event file concept: an episodic memory trace binding perceptual and motor information pertaining to an object. By adapting Hommel's paradigm to emotional faces in a previous study (Coll & Grandjean, 2016), we demonstrated that emotion could take part in an event file with motor responses...
April 19, 2018: Psychological Research
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