keyword
MENU ▼
Read by QxMD icon Read
search

Relational binding and memory

keyword
https://www.readbyqxmd.com/read/28438647/effects-of-bms-902483-an-%C3%AE-7-nicotinic-acetylcholine-receptor-partial-agonist-on-cognition-and-sensory-gating-in-relation-to-receptor-occupancy-in-rodents
#1
Rick L Pieschl, Regina Miller, Kelli M Jones, Debra J Post-Munson, Ping Chen, Kimberly Newberry, Yulia Benitex, Thaddeus Molski, Daniel Morgan, Ivar M McDonald, John E Macor, Richard E Olson, Yukiko Asaka, Siva Digavalli, Amy Easton, James Herrington, Ryan S Westphal, Nicholas J Lodge, Robert Zaczek, Linda J Bristow, Yu-Wen Li
The α7 nicotinic acetylcholine receptor is thought to play an important role in human cognition. Here we describe the in vivo effects of BMS-902483, a selective potent α7 nicotinic acetylcholine receptor partial agonist, in relationship to α7 nicotinic acetylcholine receptor occupancy. BMS-902483 has low nanomolar affinity for rat and human α7 nicotinic acetylcholine receptors and elicits currents in cells expressing human or rat α7 nicotinic acetylcholine receptors that are about 60% of the maximal acetylcholine response...
April 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28429657/what-happened-first-working-memory-and-negative-emotion-tell-you-better-evidence-from-a-temporal-binding-task
#2
Chiara Mirandola, Enrico Toffalini
Emotionally arousing events may disrupt the ability to bind together different features of items to their context; this holds true both for spatial binding (i.e. remembering the locations of previously presented items) and temporal binding (i.e. remembering the order in which different items were previously presented). Nonetheless, memory for emotional events may be enhanced in certain situations. A key factor that might explain the memory-emotion relation is represented by individual differences in cognition...
April 21, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28422060/clarifying-the-ghrelin-system-s-ability-to-regulate-feeding-behaviours-despite-enigmatic-spatial-separation-of-the-ghsr-and-its-endogenous-ligand
#3
REVIEW
Alexander Edwards, Alfonso Abizaid
Ghrelin is a hormone predominantly produced in and secreted from the stomach. Ghrelin is involved in many physiological processes including feeding, the stress response, and in modulating learning, memory and motivational processes. Ghrelin does this by binding to its receptor, the growth hormone secretagogue receptor (GHSR), a receptor found in relatively high concentrations in hypothalamic and mesolimbic brain regions. While the feeding and metabolic effects of ghrelin can be explained by the effects of this hormone on regions of the brain that have a more permeable blood brain barrier (BBB), ghrelin produced within the periphery demonstrates a limited ability to reach extrahypothalamic regions where GHSRs are expressed...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28420695/adeno-associated-viral-9-mediated-cdk5-inhibitory-peptide-reverses-pathologic-changes-and-behavioral-deficits-in-the-alzheimer-s-disease-mouse-model
#4
Yong He, Suyue Pan, Miaojing Xu, Rongni He, Wei Huang, Pingping Song, Jianou Huang, Han-Ting Zhang, Yafang Hu
Cyclin-dependent kinase 5 (Cdk5), which binds to and is activated by p35, phosphorylates multiple substrates and plays an essential role in the development and function of the CNS; however, proteolytic production of p25 from p35 under stress conditions leads to the inappropriate activation of Cdk5 and contributes to hyperphosphorylation of τ and other substrates that are related to the pathogenesis of Alzheimer's disease. Selective inhibition of aberrant Cdk5 activity via genetic overexpression of Cdk5 inhibitory peptide (CIP) reduces pathologic changes and prevents brain atrophy and memory loss in p25-transgenic mice...
April 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28416633/intrusions-in-episodic-memory-reconsolidation-or-interference
#5
Angela Klingmüller, Jeremy B Caplan, Tobias Sommer
It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a previous study). Our goal was to replicate the central result, a high intrusion rate during recall of the target list, and evaluate the reconsolidation account relative to an alternative account, based on state-dependent learning and interference...
May 2017: Learning & Memory
https://www.readbyqxmd.com/read/28413715/brain-serotonin-4-receptor-binding-is-inversely-associated-with%C3%A2-verbal-memory-recall
#6
Dea S Stenbæk, Patrick M Fisher, Brice Ozenne, Emil Andersen, Liv V Hjordt, Brenda McMahon, Steen G Hasselbalch, Vibe G Frokjaer, Gitte M Knudsen
BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall. METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [(11)C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28412148/no-evidence-to-support-a-role-for-helicobacter-pylori-infection-and-plasminogen-binding-protein-in-autoimmune-pancreatitis-and-igg4-related-disease-in-a-uk-cohort
#7
Emma L Culver, Wouter L Smit, Caroline Evans, Ross Sadler, Tamsin Cargill, Mateusz Makuch, Lai-Mun Wang, Berne Ferry, Paul Klenerman, Eleanor Barnes
BACKGROUND AND OBJECTIVES: Helicobacter pylori (H.pylori) plasminogen binding protein (PBP) has been proposed as an antigen triggering autoimmune pancreatitis (AIP), the pancreatic manifestation of IgG4-related disease (IgG4-RD). We investigated exposure to H. pylori infection, cytokine response and immunological memory to H. pylori PBP in a prospective IgG4-RD cohort in the UK. METHODS: Clinical and endoscopic evidence of peptic ulceration, serological H. pylori exposure and serum IgG4 levels were obtained in 55 IgG4-RD patients and 52 disease controls (DC) with autoimmune or inflammatory conditions with an elevated serum IgG4...
April 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28409319/the-effect-of-gamma-enhancing-binaural-beats-on-the-control-of-feature-bindings
#8
Lorenza S Colzato, Laura Steenbergen, Roberta Sellaro
Binaural beats represent the auditory experience of an oscillating sound that occurs when two sounds with neighboring frequencies are presented to one's left and right ear separately. Binaural beats have been shown to impact information processing via their putative role in increasing neural synchronization. Recent studies of feature-repetition effects demonstrated interactions between perceptual features and action-related features: repeating only some, but not all features of a perception-action episode hinders performance...
April 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28405500/zoledronate-can-induce-colorectal-cancer-microenvironment-expressing-btn3a1-to-stimulate-effector-%C3%AE-%C3%AE-t-cells-with-antitumor-activity
#9
Maria Raffaella Zocchi, Delfina Costa, Roberta Venè, Francesca Tosetti, Nicoletta Ferrari, Simona Minghelli, Roberto Benelli, Stefano Scabini, Emanuele Romairone, Silvia Catellani, Aldo Profumo, Alessandro Poggi
Amino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability to upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged as an important structure contributing to Vγ9Vδ2 T cells stimulation. It has been demonstrated that the B30.2 domain of BTN3A1 can bind phosphoantigens (PAg) and drive the activation of Vγ9Vδ2 T cells through conformational changes of the extracellular domains...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28363979/densin-180-controls-the-trafficking-and-signaling-of-l-type-voltage-gated-cav1-2-ca-2-channels-at-excitatory-synapses
#10
Shiyi Wang, Ruslan I Stanika, Xiaohan Wang, Jussara Hagen, Mary B Kennedy, Gerald J Obermair, Roger J Colbran, Amy Lee
Voltage-gated Cav1.2 and Cav1.3 (L-type) Ca(2+) channels regulate neuronal excitability, synaptic plasticity, and learning and memory. Densin-180 (densin) is an excitatory synaptic protein that promotes Ca(2+)-dependent facilitation of voltage-gated Cav1.3 Ca(2+) channels in transfected cells. Mice lacking densin (densin KO) exhibit defects in synaptic plasticity, spatial memory, and increased anxiety-related behaviors --phenotypes that more closely match those in mice lacking Cav1.2 than Cav1.3. Thus, we investigated the functional impact of densin on Cav1...
March 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28359884/administration-of-riluzole-into-the-basolateral-amygdala-has-an-anxiolytic-like-effect-and-enhances-recognition-memory-in-the-rat
#11
Azusa Sugiyama, Akiyoshi Saitoh, Misa Yamada, Jun-Ichiro Oka, Mitsuhiko Yamada
It is widely thought that inactivation of the glutamatergic system impairs recognition memory in rodents. However, we previously demonstrated that systemic administration of riluzole, which blocks the glutamatergic system, enhances recognition memory in the rat novel object recognition (NOR) test. The mechanisms underlying this paradoxical effect of riluzole on recognition memory remain unclear. In the present study, adult male Wistar rats were bilaterally cannulated in the basolateral amygdala (BLA) to examine the effects of intra-BLA administration of riluzole...
March 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28343962/contextually-mediated-spontaneous-retrieval-is-specific-to-the-hippocampus
#12
Nicole M Long, Michael R Sperling, Gregory A Worrell, Kathryn A Davis, Robert E Gross, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Joel M Stein, Michael J Kahana
Although it is now well established that the hippocampus supports memory encoding [1, 2], little is known about hippocampal activity during spontaneous memory retrieval. Recent intracranial electroencephalographic (iEEG) work has shown that hippocampal activity during encoding predicts subsequent temporal organization of memories [3], supporting a role in contextual binding. It is an open question, however, whether the hippocampus similarly supports contextually mediated processes during retrieval. Here, we analyzed iEEG recordings obtained from 215 epilepsy patients as they performed a free recall task...
April 3, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28337159/hey-teacher-don-t-leave-them-kids-alone-action-is-better-for-memory-than-reading
#13
Mathieu Hainselin, Laurence Picard, Patrick Manolli, Sophie Vankerkore-Candas, Béatrice Bourdin
There is no consensus on how the enactment effect (EE), although it is robust, enhances memory. Researchers are currently investigating the cognitive processes underlying this effect, mostly during adulthood; the link between EE and crucial function identified in adulthood such as episodic memory and binding process remains elusive. Therefore, this study aims to verify the existence of EE in 6-10 years old and assess cognitive functions potentially linked to this effect in order to shed light on the mechanisms underlying the EE during childhood...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28333504/healthy-aging-and-visual-working-memory-the-effect-of-mixing-feature-and-conjunction-changes
#14
Stephen Rhodes, Mario A Parra, Nelson Cowan, Robert H Logie
It has been suggested that an age-related decrease in the ability to bind and retain conjunctions of features may account for some of the pronounced decline of visual working memory (VWM) across the adult life span. So far the evidence for this proposal has been mixed with some suggesting a specific deficit in binding to location, while the retention of surface feature conjunctions (e.g., color-shape) appears to remain largely intact. The present experiments follow up on the results of an earlier study, which found that older adults were specifically poor at detecting conjunction changes when they were mixed with trials containing changes to individual features, relative to when these trials were blocked (Cowan, Naveh-Benjamin, Kilb, & Saults, 2006)...
March 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28321185/sex-matters-hippocampal-volume-predicts-individual-differences-in-associative-memory-in-cognitively-normal-older-women-but-not-men
#15
Zhiwei Zheng, Rui Li, Fengqiu Xiao, Rongqiao He, Shouzi Zhang, Juan Li
The hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28286180/dysregulation-of-bet-proteins-in-levodopa-induced-dyskinesia
#16
David A Figge, David G Standaert
Levodopa (L-DOPA) remains the most effective pharmacological treatment for Parkinson Disease (PD) but its use is limited by the development of debilitating drug-related side effects, particularly L-DOPA induced dyskinesia (LID). LID is a consequence of long-term L-DOPA use, and in model systems is characterized by a "priming effect", whereby initial administrations of L-DOPA trigger a sensitized biochemical and transcriptional response upon subsequent dopaminergic stimulation. Preliminary studies into the mechanisms underlying this cellular memory have indicated an important role for epigenetic change but many of the downstream mechanisms remain unknown...
June 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28283662/exhaustion-associated-regulatory-regions-in-cd8-tumor-infiltrating-t-cells
#17
Giuliana P Mognol, Roberto Spreafico, Victor Wong, James P Scott-Browne, Susan Togher, Alexander Hoffmann, Patrick G Hogan, Anjana Rao, Sara Trifari
T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TILs) that recognize a model tumor antigen and have features of both activation and functional exhaustion. By filtering out accessible regions observed in bystander, nonexhausted TILs and in acutely restimulated CD8(+) T cells, we define a pattern of chromatin accessibility specific for T-cell exhaustion, characterized by enrichment for consensus binding motifs for Nr4a and NFAT transcription factors...
March 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28278364/methyl-cpg-level-at-distal-part-of-heat-shock-protein-promoter-hsp70-exhibits-epigenetic-memory-for-heat-stress-by-modulating-recruitment-of-pou2f1-associated-nucleosome-remodeling-deacetylase-nurd-complex
#18
Tatiana Kisliouk, Tomer Cramer, Noam Meiri
Depending on its stringency, exposure to heat in early life leads to either resilience or vulnerability to heat stress later in life. We hypothesized that epigenetic alterations in genes belonging to the cell proteostasis pathways are attributed to long-term responses to heat stress. Epigenetic regulation of the mRNA expression of the molecular chaperone heat-shock protein (HSP) 70 (HSPA2) was evaluated in the chick hypothalamus during the critical period of thermal-control establishment on day 3 post-hatch and during heat challenge on day 10...
March 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28275781/aqueous-extracts-from-asparagus-stems-prevent-memory-impairments-in-scopolamine-treated-mice
#19
Zifang Sui, Ce Qi, Yunxiang Huang, Shufeng Ma, Xinguo Wang, Guowei Le, Jin Sun
Aqueous extracts from Asparagus officinalis L. stems (AEAS) are rich in polysaccharides, gamma-amino butyric acid (GABA), and steroidal saponin. This study was designed to investigate the effects of AEAS on learning, memory, and acetylcholinesterase-related activity in a scopolamine-induced model of amnesia. Sixty ICR mice were randomly divided into 6 groups (n = 10) including the control group (CT), scopolamine group (SC), donepezil group (DON), low, medium, and high dose groups of AEAS (LS, MS, HS; 1.6 mL kg(-1), 8 mL kg(-1), 16 mL kg(-1))...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28275159/enduring-memory-impairments-provoked-by-developmental-febrile-seizures-are-mediated-by-functional-and-structural-effects-of-neuronal-restrictive-silencing-factor
#20
Katelin P Patterson, Jeremy M Barry, Megan M Curran, Akanksha Singh-Taylor, Gary Brennan, Neggy Rismanchi, Matias Page, Yoav Noam, Gregory L Holmes, Tallie Z Baram
In a subset of children experiencing prolonged febrile seizures (FSs), the most common type of childhood seizures, cognitive outcomes are compromised. However, the underlying mechanisms are unknown. Here we identified significant, enduring spatial memory problems in male rats following experimental prolonged FS (febrile status epilepticus; eFSE). Remarkably, these deficits were abolished by transient, post hoc interference with the chromatin binding of the transcriptional repressor neuron restrictive silencing factor (NRSF or REST)...
April 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
115983
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"