Jiuyang Ding, Yuanhe Wang, Zhuo Wang, Shanshan Hu, Zhu Li, Cuiyun Le, Jian Huang, Xiang Xu, Jiang Huang, Pingming Qiu
Methamphetamine (METH) can cause kidney dysfunction. Luteolin is a flavonoid compound that can alleviate kidney dysfunction. We aimed to observe the renal-protective effect of luteolin on METH-induced nephropathies and to clarify the potential mechanism of action. The mice were treated with METH (1.0-20.0 mg/kg/d bodyweight) for 14 consecutive days. Morphological studies, renal function, and podocyte specific proteins were analyzed in the chronic METH model in vivo. Cultured podocytes were used to support the protective effects of luteolin on METH-induced podocyte injury...
2022: Evidence-based Complementary and Alternative Medicine: ECAM