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https://www.readbyqxmd.com/read/29052315/identification-and-evolution-of-latrophilin-receptor-gene-involved-in-tribolium-castaneum-devolopment-and-female-fecundity
#1
Shanshan Gao, Xing Liu, Juanjuan Liu, Wenfeng Xiong, Xiaowen Song, Wu Wei, Luting Wei, Bin Li
Latrophilins (LPHs) are adhesion G-protein-coupled receptors comprising three paralogous forms (LPH-1, LPH-2 and LPH-3) and known receptors for α-latrotoxin, which are involved in growth, development, adaptability and schizophrenia and other diseases in vertebrates. However, the functions of LPH are poorly understood in most insects. Here, phylogenetic and synteny analysis indicated that LPH-1 and LPH-3 evolved separately from a common ancestor LPH-2. Then, latrophilin (Tclph) was cloned in Tribolium castaneum, and three alternatively spliced transcripts (Tclpha, Tclphb and Tclphc) were identified...
October 20, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29046817/fertility-with-early-reduction-of-ovarian-reserve-the-last-straw-that-breaks-the-camel-s-back
#2
REVIEW
Sabahat Rasool, Duru Shah
Diminished fertility and poor ovarian response pose a conundrum to the experts in the field of reproductive medicine. There is limited knowledge about the risk factors of diminished ovarian reserve other than the iatrogenic ones. One of the leading causes of infertility in women today is diminished ovarian reserve (DOR). DOR is characterized by a low number of eggs in a woman's ovaries and/or with poor quality of the remaining eggs, which boils down to impaired development of the existing eggs, even with assisted reproductive techniques...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/29044581/women-with-polycystic-ovary-syndrome-demonstrate-worsening-markers-of-cardiovascular-risk-over-the-short-term-despite-declining-hyperandrogenaemia-results-of-a-longitudinal-study-with-community-controls
#3
Heather G Huddleston, Molly M Quinn, Chia-Ning Kao, Nikolaus Lenhart, Mitchell P Rosen, Marcelle I Cedars
OBJECTIVE: To compare age-associated changes in cardiovascular risk markers in lean and obese reproductive-aged women with polycystic ovary syndrome (PCOS) with community controls DESIGN: Longitudinal study at an academic medical centre. PATIENTS: Patients diagnosed with PCOS by 2004 Rotterdam criteria in a multi-disciplinary clinic were systematically enrolled from 2006-2014 in a PCOS cohort study and subsequently agreed to participate in a longitudinal study. The comparison controls were from the prospective, longitudinal Ovarian Aging (OVA) study, which consists of healthy women with regular menstrual cycles recruited from 2006 to 2011...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29040417/neonatal-immune-activation-depletes-the-ovarian-follicle-reserve-and-alters-ovarian-acute-inflammatory-mediators-in-neonatal-rats
#4
Erin A Fuller, Luba Sominsky, Jessie M Sutherland, Kate A Redgrove, Lauren Harms, Eileen A McLaughlin, Deborah M Hodgson
Normal ovarian development is crucial for female reproductive success and longevity. Interruptions to the delicate process of initial folliculogenesis may lead to ovarian dysfunction. We have previously demonstrated that an early life immune challenge in the rat, induced by administration of lipopolysaccharide (LPS) on postnatal day (PND) 3 and 5, depletes ovarian follicle reserve long term. Here, we hypothesised that this neonatal immune challenge leads to an increase in peripheral and ovarian inflammatory signalling, contributing to an acute depletion of ovarian follicles...
October 10, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29030978/types-of-cell-death-and-apoptotic-stages-in-chinese-hamster-ovary-cells-distinguished-by-raman-spectroscopy
#5
Shreyas Rangan, Sepehr Kamal, Stanislav O Konorov, H Georg Schulze, Michael W Blades, Robin F B Turner, James M Piret
Cell death is the ultimate cause of productivity loss in bioreactors that are used to produce therapeutic proteins. We investigated the ability of Raman spectroscopy to detect the onset and types of cell death for Chinese Hamster Ovary (CHO) cells - the most widely used cell type for therapeutic protein production. Raman spectroscopy was used to compare apoptotic, necrotic, autophagic and control CHO cells. Several specific nucleic acid-, protein- and lipid-associated marker bands within the 650-850 cm(-1) spectral region were identified that distinguished among cells undergoing different modes of cell death; supporting evidence was provided by principal component analysis of the full spectral data...
October 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29024578/morpho-functional-features-of-the-gonads-of-danio-rerio-the-role-of-brain-derived-neurotrophic-factor
#6
Pietro Cacialli, Livia D'Angelo, Paolo de Girolamo, Luigi Avallone, Carla Lucini, Elisabeth Pellegrini, Luciana Castaldo
Zebrafish, a suitable and widely used teleost fish model in basic biomedical research, displays morphophysiological features of adult gonads that share some commonalities with those of mammalian species. In mammals, gametogenesis is regulated, among several factors, by brain derived neurotrophic factor (BDNF). This neurotrophin has a well-established role in the developing and adult nervous system, as well as gonads development and functions in vertebrates pecies. We hypothesize that BDNF has a role also in the gonadal functions of zebrafish...
October 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29024517/germ-cell-migration-proliferation-and-differentiation-during-gonadal-morphogenesis-in-all-female-japanese-flounder-paralichthys-olivaceus
#7
Yang Yang, Qinghua Liu, Yongshuang Xiao, Xueying Wang, Hao An, Zongcheng Song, Feng You, Yanfeng Wang, Daoyuan Ma, Jun Li
In this study, all genetic female(XX)broods of Japanese flounder were produced artificially by mating the females with sex-reversed males. The proliferation and migration of primordial germ cells (PGCs), formation of ovary and oogenesis were described in detail. After hatching, around 20 individual PGCs migrated from the lateral to the dorsal of trunk region. At 15 days post hatching (dph), a part of PGCs were covered by a single layer somatic cells and formed the genital ridge. By 22 dph, the elongated gonadal primordia appeared under the ventral kidney, where the PGCs were totally enclosed by somatic cells...
October 10, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28981984/obstetrical-complications-in-dichorionic-twin-pregnancies-in-women-with-polycystic-ovary-syndrome
#8
Fjola Jonsdottir, Lisbeth Nilas, Kirsten R Andreasen, Jørgen Grinsted, Michael Christiansen, Paula L Hedley, Klara V Naver
INTRODUCTION: Both women with polycystic ovary syndrome (PCOS) and women with twin pregnancies have increased risk of adverse pregnancy outcome. The aim of this study was to investigate the impact of PCOS and maternal androgen levels on the outcome of dichorionic twin pregnancy. MATERIAL AND METHODS: A retrospective study of 360 women with dichorionic twin pregnancies: 72 PCOS women from a fertility clinic (years 1997 to 2010) and 288 non-PCOS women from a hospital cohort (years 2005 to 2007)...
October 5, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28981118/overactive-type-2-cannabinoid-receptor-induces-meiosis-in-fetal-gonads-and-impairs-ovarian-reserve
#9
Emanuela De Domenico, Federica Todaro, Gabriele Rossi, Susanna Dolci, Raffaele Geremia, Pellegrino Rossi, Paola Grimaldi
Type 2 cannabinoid receptor (CB2R) has been proposed to promote in vitro meiotic entry of postnatal male germ cells and to maintain the temporal progression of spermatogenesis in vivo. However, no information is presently available on the role played by CB2R in male and female fetal gonads. Here we show that in vitro pharmacological stimulation with JWH133, a CB2R agonist, induced activation of the meiotic program in both male and female fetal gonads. Upon stimulation, gonocytes initiated the meiotic program but became arrested at early stages of prophase I, while oocytes showed an increased rate of meiotic entry and progression toward more advanced stage of meiosis...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28980406/characterization-and-functional-analysis-of-hsp18-3-gene-in-the-red-flour-beetle-tribolium-castaneum
#10
Jia Xie, Xing-Xing Hu, Meng-Fan Zhai, Xiao-Juan Yu, Xiao-Wen Song, Shan-Shan Gao, Wei Wu, Bin Li
Small heat shock proteins (sHSPs) are diverse and mainly function as molecular chaperones to protect organisms and cells from various stresses. In this study, hsp18.3, one Tribolium castaneum species-specific shsp, has been identified. Quantitative real-time PCR (qRT-PCR) illustrated that Tchsp18.3 is expressed in all developmental stages, and is highly expressed at early pupal and late adult stages. While, it highly expressed in ovary and fat body at adult period. Moreover, it was up-regulated 4532 ± 396-fold in response to enhanced heat stress but not to cold stress, meanwhile the lifespan of adults in ds-Tchsp18...
October 5, 2017: Insect Science
https://www.readbyqxmd.com/read/28980338/clinical-case-seminar-post-menopausal-ovarian-androgen-excess-challenges-in-diagnostic-work-up-and-management-of-ovarian-thecosis
#11
Yaasir Mamoojee, Murali Ganguri, Norman Taylor, Richard Quinton
A 72 year old female was referred to the Department of Endocrinology with a 20-year history of hirsutes, mostly affecting her face and torso, the initial onset of which dated shortly after menopause age 52 years. There was no history of subfertility, menstrual irregularity, or hyperandrogenism during reproductive life to suggest prior polycystic ovary syndrome (PCOS), with three live births, two miscarriages and one still-birth. This article is protected by copyright. All rights reserved.
October 4, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28959655/first-report-on-distribution-of-heavy-metals-and-proximate-analysis-in-marine-edible-puffer-fishes-collected-from-gulf-of-mannar-marine-biosphere-reserve-south-india
#12
Kaleshkumar Karunanidhi, Rajaram Rajendran, Dhinesh Pandurangan, Ganeshkumar Arumugam
In the present study, the heavy metal concentration in different organs (skin, tissue, liver, kidney, gill, intestine, and ovary) and muscle proximate composition were studied in marine edible puffer fishes Takifugu oblongus, Lagocephalus guentheri, Arothron hispidus, Chelonodon patoca and Arothron immaculatus collected from Mandapam fish landing centre, South east coast of India. Heavy metals (Cd, Cu, Pb & Zn) were analyzed in different organs for the above mentioned species. The heavy metals concentration ranges in fish organs of all the five species were Cu (0...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28955058/predictive-accuracy-of-anti-mullerian-hormone-as-indicator-of-ovarian-follicle-loss-in-cyclophosphamide-treated-mice
#13
Zehra Jamil, Khalida Perveen, Rabia Malik, Lubna Avesi
OBJECTIVE: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide. METHODS: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28949024/age-stratified-thresholds-of-anti-m%C3%A3-llerian-hormone-improve-prediction-of-polycystic-ovary-syndrome-over-a-population-based-threshold
#14
Didier Dewailly
No abstract text is available yet for this article.
September 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28941255/effects-of-placebo-controlled-insulin-sensitizing-drugs-on-hormonal-parameters-in-polycystic-ovary-syndrome-patients-a-network-meta-analysis
#15
Yong-Hui Dai, Rong Huang, Peng-Fei Zhao, Jian-Hua Xu, Dong-Dong Liu, Fu-Dong Luo
This network meta-analysis was conducted to compare effects of different placebo-controlled insulin-sensitizing drugs, including metformin, pioglitazone, rosiglitazone and troglitazone on hormonal parameters in polycystic ovary syndrome (PCOS) patients. We searched PubMed, EMBASE and Cochrane Library databases from their inception to July 2017. Randomized controlled trials (RCTs) met our inclusion criteria were included. We combined direct and indirect evidences to evaluate weighted mean difference (WMD) value and draw surface under the cumulative ranking curve (SUCRA)...
September 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28941069/identification-and-functional-analysis-of-chitin-synthase-a-in-oriental-armyworm-mythimna-separata
#16
Yifan Zhai, Xiaobin Fan, Zhenjuan Yin, Xiangzhao Yue, Xingyuan Men, Li Zheng, Wenqing Zhang
Chitin synthases are very important enzymes for chitin synthesis in various species, which makes them a specific target of insecticides. In the present study, we investigated the function of the chitin synthase A (CHSA) gene isolated from Mythimna separata. The majority of dsMysCHSA treated larvae (89.50%) exhibited lethal phenotypes, including three phenotypes with severe cuticle deformations. The dsMysCHSA treatment in adult females affected oogenesis, and significantly reduced the ovary size and the oviposition number compared with controls...
September 22, 2017: Proteomics
https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#17
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938488/ovarian-aging-in-women-with-brca-germline-mutations
#18
Wayne Lin, Shiny Titus, Fred Moy, Elizabeth S Ginsburg, Kutluk Oktay
Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage but the direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A laboratory comparative study of ovarian tissue obtained from the risk-reducing salpingo- oophorectomy (RRSO) samples of unaffected BRCA mutation carrier (BMC) women vs...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28933574/is-there-a-role-for-kisspeptin-in-pathogenesis-of-polycystic-ovary-syndrome
#19
Umit Gorkem, Cihan Togrul, Emine Arslan, Ayla Sargin Oruc, Nuriye Buyukkayaci Duman
AIM: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28930606/association-between-ovarian-endometrioma-and-ovarian-reserve
#20
Michio Kitajima, Khaleque Newaz Khan, Ayumi Harada, Ken Taniguchi, Tsuneo Inoue, Masanori Kaneuchi, Kiyonori Miura, Hideaki Masuzaki
Endometrioma is one of the main pathologies of endometriosis, though its pathogenesis still remains enigmatic. Ovarian reserve is defined as the number and quality of the follicles left in the ovary at any given time. The cause of infertility in women with endometriosis is multifactorial. Diminished ovarian reserve is major concern in women with endometriosis-associated infertility. Cystectomy for endometriomas could negatively impact on post-operative ovarian reserve. Some women had surgery for endometriomas suffer from poor ovarian response, which directly affects treatment results...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
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