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https://www.readbyqxmd.com/read/28506471/genetics-of-gonadotropins-and-their-receptors-as-markers-of-ovarian-reserve-and-response-in-controlled-ovarian-stimulation
#1
REVIEW
Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Daniele Santi, Giulia Brigante, Manuela Simoni, Livio Casarini
Several controlled ovarian stimulation (COS) protocols have been developed to increase the yield of mature oocytes retrieved in assisted reproductive techniques (ARTs). The ovarian reserve (OR) influences the COS response, and it represents the main parameter that helps clinicians in refining clinical treatments in the perspective of a "personalized" ART. This approach is even more needed in particular conditions such as poor OR or polycystic ovary syndrome. Follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin are currently used in COS at different combinations and with different efficacies, even if the best approach definition is controversial...
April 17, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28502234/a-gonadotropin-releasing-hormone-agonist-for-the-prevention-of-docetaxel-induced-gonadal-damage
#2
Ilhae Park, Sanghoon Lee, Ki-Jin Ryu, Kyung-Jin Min, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
This study aimed to evaluate the protective effect of a gonadotropin-releasing hormone (GnRH) agonist against docetaxel-induced gonadotoxicity in a mouse model. Forty mice (female B6, 6-8 weeks old, weighing 16-18 g) were divided randomly into four groups. Groups 1 and 2 were treated with a single intraperitoneal dose of 0.1 mL normal saline; Groups 3 and 4 received 30 mg/kg docetaxel. Groups 2 and 4 were pre-treated with a subcutaneous injection of 0.3 mg leuprolide acetate, 2 weeks before the administration of docetaxel...
May 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28488746/corpora-lutea-control-the-progression-of-small-antral-follicle-growth-in-the-pig-ovary
#3
Holly A LaVoie
No abstract text is available yet for this article.
May 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28485095/comparison-of-myo-inositol-and-metformin-on-clinical-metabolic-and-genetic-parameters-in-polycystic-ovary-syndrome-a-randomized-controlled-clinical-trial
#4
Mehri Jamilian, Pegah Farhat, Fatemeh Foroozanfard, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Fereshteh Bahmani, Bita Badehnoosh, Hamidreza Jamilian, Zatollah Asemi
OBJECTIVE: To our knowledge, data on comparison of myo-inositol and metformin on clinical, metabolic and genetic parameters in subjects with polycystic ovary syndrome (PCOS) are limited. This study was carried out to compare myo-inositol and metformin on clinical, metabolic and genetic parameters in subjects with PCOS. DESIGN, PATIENTS AND MEASUREMENTS: This randomized controlled trial was conducted among 60 subjects with PCOS aged 18-40 years. Subjects were randomly allocated into two groups to receive either myo-inositol (N=30) or metformin (N=30) for 12 weeks...
May 9, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28467682/transcriptional-control-of-genes-mediating-ovarian-follicular-growth-differentiation-and-steroidogenesis-in-pigs
#5
REVIEW
Holly A LaVoie
The pig is an agriculturally important species, so understanding its follicular dynamics and the transcriptional events that accompany such changes is critical to optimizing reproductive outcomes. Numerous small- to medium-size antral follicles are recruited and continue growth under the influence of gonadotropins and growth factors during the follicular phase of the porcine estrous cycle. Several of these follicles are selected to mature into large preovulatory follicles whose granulosa cells acquire luteinizing hormone (LH) receptors...
May 3, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28443590/effects-of-apigenin-on-experimental-ischemia-reperfusion-injury-in-the-rat-ovary
#6
Zeynep Soyman, Sefa Kelekçi, Veysel Sal, Osman Şevket, Nihan Bayındır, Hafize Uzun
BACKGROUND: Apigenin, is a plant-derived compound belonging to flavone class, possess antioxidant, free radical scavenging and anti-inflammatory manners. AIMS: This paper aims to address effects of apigenin upon serum antimüllerian hormone (AMH) levels, tissue oxidative stress parameters and histopathological changes in ovarian ischemia/reperfusion (I/R) injury. STUDY DESIGN: Animal experiment. METHODS: Twenty eight female Wistar albino rats have been separated to four sections in a random way: Sham operation (Group 1), I/R plus saline (Group 2), I/R plus dimethyl sulfoxide (Group 3) and I/R plus apigenin (Group 4)...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28441841/-an-experiment-control-study-on-the-ovarian-reserve-function-after-cisplatin-intraperitoneal-or-intravenous-chemotherapy-in-rats-model
#7
B Z Fan, H Xia, L Chu, X W Tong
Objective: To compare the impact on the ovarian reserve function after cisplatin intraperitoneal or intravenous chemotherapy in rats model. Methods: Thirty 8-weeks old female Sprague Dawley rats were randomly assigned to control group (group A, n=10), intraperitoneal chemotherapy group (group B, n=10) and intravenous chemotherapy group (group C, n=10). Cisplatin was diluted by normal saline (NS) into 4 mg/ml. On the first day of chemotherapy, 0.2 ml cisplatin dilution was injected into the abdomen of rats in group B, isodose cisplatin was injected into vein and 1...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28439882/prevalence-and-clinical-relevance-of-tsh-receptor-blocking-antibodies-in-autoimmune-thyroid-disease
#8
T Diana, J Krause, P D Olivo, J König, M Kanitz, B Decallonne, G J Kahaly
OBJECTIVE: The prevalence and clinical relevance of TSH-receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated. METHODS: Serum TBAb were measured with a reporter gene bioassay using chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). All samples were measured for TSHR stimulatory Ab (TSAb) and TSHR binding inhibiting immunoglobulins (TBII)...
April 25, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28436007/overexpression-of-the-regulatory-subunit-of-glutamate-cysteine-ligase-enhances-monoclonal-antibody-production-in-cho-cells
#9
Camila A Orellana, Esteban Marcellin, Peter P Gray, Lars K Nielsen
For decades, Chinese hamster ovary (CHO) cells have been the preferred host for therapeutic monoclonal antibody (mAb) production; however, increasing mAb titer by rational engineering remains a challenge. Our previous proteomic analysis in CHO cells suggested that a higher content of glutathione (GSH) might be related to higher productivity. GSH is an important antioxidant, cell detoxifier, and is required to ensure the formation of native disulfide bonds in proteins. To investigate the involvement of GSH in mAb production, we generated stable CHO cell lines overexpressing genes involved in the first step of GSH synthesis; namely the glutamate-cysteine ligase catalytic subunit (Gclc) and the glutamate-cysteine ligase modifier subunit (Gclm)...
April 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28432753/identification-of-indothiazinone-as-a-natural-antiplatelet-agent
#10
Chansik Yang, Sugyeong Kwon, Se-Jong Kim, Minseon Jeong, Ji-Young Park, Dongeun Park, Soon Jun Hong, Jong-Wha Jung, Chungho Kim
Cardiovascular disease, which is caused by unregulated platelet aggregation, is one of the main causes of deaths worldwide. Many studies have focused on natural products with antiplatelet effects as a safe alternative therapy to prevent the disease. In this context, an in-house chemical library was screened to find natural products capable of inhibiting the interaction between platelet integrin αIIbβ3 and fibrinogen, which is an essential step in platelet aggregation. On the basis of the screening results, indothiazinone, an alkaloid found in microbial cultures, was identified as a potential antiplatelet agent...
April 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28421694/molecular-engineering-and-plant-expression-of-an-immunoglobulin-heavy-chain-scaffold-for-delivery-of-a-dengue-vaccine-candidate
#11
Mi-Young Kim, Craig Van Dolleweerd, Alastair Copland, Matthew John Paul, Sven Hofmann, Gina R Webster, Emily Julik, Ivonne Ceballos-Olvera, Jorge Reyes-Del Valle, Moon-Sik Yang, Yong-Suk Jang, Rajko Reljic, Julian K Ma
In order to enhance vaccine uptake by the immune cells in vivo, molecular engineering approach was employed to construct a Polymeric Immunoglobulin G Scaffold (PIGS) that incorporates multiple copies of an antigen and targets the Fc gamma receptors on antigen-presenting cells. These self-adjuvanting immunogens were tested in the context of dengue infection, for which there is currently no globally licensed vaccine yet. Thus, the consensus domain III sequence (cEDIII) of dengue glycoprotein E was incorporated into PIGS and expressed in both tobacco plants and Chinese Ovary Hamster cells...
April 19, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28412866/comparison-of-the-morphokinetic-parameters-of-embryos-according-to-ovarian-reserve-in-ivf-cycles
#12
Suleyman Akarsu, Funda Gode, Ahmet Zeki Isik, Hayriye Celenk, Ferda Burcu Tamer, Selcuk Erkilinc
The aim of this study is to evaluate the impact of ovarian reserve and age of women on early morphokinetic parameters of embryos with a time-lapse monitoring system. In total, 197 infertile couples with poor ovarian reserve (Group 1, n = 41), normal ovarian reserve (Group 2, n = 59), or polycystic ovaries (Group 3, n = 97) were included. The time from insemination to the following events were analyzed: pronuclear fading (Pnf) and cleavage to 2, 3, 4 and 5 cells. The optimal ranges for morphokinetic parameters of t5, s2 and cc2 in each group were also evaluated...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28412857/prevalence-of-diminished-ovarian-reserve-in-chinese-women-with-polycystic-ovary-syndrome-and-sensitive-diagnostic-parameters
#13
Jing Jin, Xiangyan Ruan, Lin Hua, Xuanxuan Tian, Yanglu Li, Lijuan Wang, Alfred O Mueck
OBJECTIVES: To assess the prevalence of diminished ovarian reserve (DOR) in patients with polycystic ovary syndrome (PCOS) in China, and to search for sensitive diagnostic parameters. METHODS: Three hundred and thirty eight PCOS women aged 20-39 years were recruited. Basic characteristics, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone and anti-Müllerian hormone (AMH) were measured. The best indices to diagnose PCOS with DOR were assessed...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28409838/modulation-and-modeling-of-monoclonal-antibody-n-linked-glycosylation-in-mammalian-cell-perfusion-reactors
#14
Daniel J Karst, Ernesto Scibona, Elisa Serra, Jean-Marc Bielser, Jonathan Souquet, Matthieu Stettler, Hervé Broly, Miroslav Soos, Massimo Morbidelli, Thomas K Villiger
Mammalian cell perfusion cultures are gaining renewed interest as an alternative to traditional fed-batch processes for the production of therapeutic proteins, such as monoclonal antibodies (mAb). The steady state operation at high viable cell density allows the continuous delivery of antibody product with increased space-time yield and reduced in-process variability of critical product quality attributes (CQA). In particular, the production of a confined mAb N-linked glycosylation pattern has the potential to increase therapeutic efficacy and bioactivity...
April 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28409824/a-comparative-genomic-hybridization-approach-to-study-gene-copy-number-variations-among-chinese-hamster-cell-lines
#15
Nandita Vishwanathan, Arpan Bandyopadhyay, Hsu-Yuan Fu, Kathryn C Johnson, Nathan M Springer, Wei-Shou Hu
Chinese Hamster Ovary (CHO) cells are aneuploid in nature. The genome of recombinant protein producing CHO cell lines continuously undergoes changes in its structure and organization. We analyzed nine cell lines, including parental cell lines, using a comparative genomic hybridization (CGH) array focused on gene-containing regions. The comparison of CGH with copy-number estimates from sequencing data showed good correlation. Hierarchical clustering of the gene copy number variation data from CGH data revealed the lineage relationships between the cell lines...
April 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28409820/identification-and-control-of-novel-growth-inhibitors-in-fed-batch-cultures-of-chinese-hamster-ovary-cells
#16
Bhanu Chandra Mulukutla, Jaitashree Kale, Taylor Kalomeris, Michaela Jacobs, Gregory W Hiller
Chinese hamster ovary (CHO) cells in culture are known to consume large amounts of nutrients and divert most of them towards byproducts, some of which, including lactate and ammonia, are known to be toxic in nature. Glucose limitation strategies can successfully control lactate accumulation in fed-batch cultures yielding higher peak cell densities and titers. Interestingly, even in such optimized cultures, cell growth slows and eventually stops, indicating the emergence of other factors that negatively affect cell growth...
April 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28401606/transcriptional-polymorphism-of-pirna-regulatory-genes-underlies-the-mariner-activity-in-d-simulans-testes
#17
Bastien Saint-Leandre, Isabelle Clavereau, Aurelie Hua-Van, Pierre Capy
During colonization of new areas, natural populations have to deal with changing environments, and transposable elements (TEs) can be useful "tools" in the adaptation process since they are major contributor to the structural and functional evolution of genomes. In this general context, the activity (copy number, transcriptional and excision rate) of the mariner mos1 element was estimated in 19 natural populations of D. simulans. It is shown (1) that mos1 expression is always higher and more variable in testes than in ovaries; (2) that mos1 activity is higher in colonizing populations compared to the sub-Saharan African ones (ancestral populations); (3) that mos1 variations in transcript levels and copy number are negatively correlated to transcriptional variations of piRNA genes, aubergine and argonaute3...
April 12, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28390152/reproductive-morphology-of-oarfish-regalecus-russellii
#18
Kristy L Forsgren, Homam Jamal, Andrew Barrios, E W Misty Paig-Tran
Reproduction is a critical aspect of understanding the biology of fishes. Relatively little is known about oarfish (Regalecus russellii) reproduction, however strandings of dead animals have provided a rare opportunity to investigate the gonadal morphology of four fish; two females and two males. A female collected in June 2015 (4.32 m TL) had bifurcated ovaries 2.14 m in length and 2.14 kg. The gonadosomatic index (GSI) was 11.8% and the fish was determined to be spawning capable/spawning reproductive phase...
April 8, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28390103/asn1-encoded-asparagine-synthetase-in-floral-organs-contributes-to-nitrogen-filling-in-arabidopsis-seeds
#19
Laure Gaufichon, Anne Marmagne, Katia Belcram, Tadakatsu Yoneyama, Yukiko Sakakibara, Toshiharu Hase, Olivier Grandjean, Gilles Clément, Sylvie Citerne, Stéphanie Boutet-Mercey, Céline Masclaux-Daubresse, Fabien Chardon, Fabienne Soulay, Xiaole Xu, Marion Trassaert, Maryam Shakiebaei, Amina Najihi, Akira Suzuki
Despite a general view that asparagine synthetase generates asparagine as an amino acid for long-distance transport of nitrogen to sink organs, its role in nitrogen metabolic pathways in floral organs during seed nitrogen filling has remained undefined. We demonstrate that the onset of pollination in Arabidopsis induces selected genes for asparagine metabolism, namely ASN1 (At3g47340), GLN2 (At5g35630), GLU1 (At5g04140), AapAT2 (At5g19950), ASPGA1 (At5g08100) and ASPGB1 (At3g16150), particularly at the ovule stage (stage 0), accompanied by enhanced asparagine synthetase protein, asparagine and total amino acids...
April 8, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28389520/oocyte-stem-cells-fact-or-fantasy
#20
Corrina J Horan, Suzannah Alice Williams
For many decades, the dogma prevailed that female mammals had a finite pool of oocytes at birth and this was gradually exhausted during a lifetime of reproductive function. However, in 2004, a new era began in the field of female oogenesis. A study was published that appeared to detect oocyte-stem cells capable of generating new eggs within mouse ovaries. This study was highly controversial and the years since this initial finding have produced extensive research and even more extensive debate into their possibility...
April 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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