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https://www.readbyqxmd.com/read/29454130/abscess-within-a-glioblastoma-mimicking-a-matryoshka-doll
#1
Kislay Kishore, Manish Beniwal, Shilpa Rao, K V L N Rao, Vikas Vazhayil, Dwarkanath Srinivas, Sampath Somanna
BACKGROUND: Abscess co-existing within a brain tumor is a rare entity. Case reports in literature primarily consist of sellar pathology and parenchymal lesions including meningioma, glioma, and metastases. We report a case of glioblastoma with an intra-tumoral abscess in a middle-aged lady with no prior invasive procedure or systemic focus of infection. CASE DESCRIPTION: A 45-year old lady presented with new onset generalized seizures and rapidly progressive left hemiparesis...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453893/cbct-guided-evolutive-library-for-cervical-adaptive-imrt
#2
Bastien Rigaud, Antoine Simon, Maxime Gobeli, Caroline Lafond, Julie Leseur, Anais Barateau, Nicolas Jaksic, Joël Castelli, Danièle Williaume, Pascal Haigron, Renaud De Crevoisier
PURPOSE: In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. MATERIAL AND METHODS: For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs (with empty [EB], intermediate [IB], and full [FB] bladder volumes), a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed...
February 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29453846/fabrication-of-miniature-elastomer-lenses-with-programmable-liquid-mold-for-smartphone-microscopy-curing-polydimethylsiloxane-with-in-situ-curvature-control
#3
Bhuvaneshwari Karunakaran, Joseph Tharion, Arvind Ramrao Dhawangale, Debjani Paul, Soumyo Mukherji
Miniature lenses can transform commercial imaging systems, e.g., smartphones and webcams, into powerful, low-cost, handheld microscopes. To date, the reproducible fabrication of polymer lenses is still a challenge as they require controlled dispensing of viscous liquid. This paper reports a reproducible lens fabrication technique using liquid mold with programmable curvature and off-the-shelf materials. The lens curvature is controlled during fabrication by tuning the curvature of an interface of two immiscible liquids [polydimethylsiloxane (PDMS) and glycerol]...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29453592/patient-specific-registration-of-3d-ct-angiography-cta-with-x-ray-fluoroscopy-for-image-fusion-during-transcatheter-aortic-valve-implantation-tavi-increases-performance-of-the-procedure
#4
I Vernikouskaya, W Rottbauer, J Seeger, B Gonska, V Rasche, Jochen Wöhrle
OBJECTIVES: The aim of this study was to adapt patient-specifically a co-registration procedure for image fusion (IF) of a pre-interventional CT dataset with real-time X-ray (XR) fluoroscopy during transfemoral transcatheter aortic valve implantation (TAVI), enabling improved performance of the procedure. BACKGROUND: The ability to use 3D models of the respective anatomies to complement the anatomic information obtained by XR fluoroscopy and provide a greater degree of real-time anatomical guidance holds great potential for complex cardiac interventions, especially for TAVI procedures with cerebral protection...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29452620/pathogen-specific-bacterial-imaging-in-nuclear-medicine
#5
REVIEW
Alvaro A Ordonez, Sanjay K Jain
When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques often rely on tissue biopsies to obtain clinical samples which can be expensive, dangerous, and has the potential of sampling bias. Moreover, these procedures and results can take several days and may not always provide reliable information...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452615/fever-of-unknown-origin-the-value-of-fdg-pet-ct
#6
REVIEW
Ilse J E Kouijzer, Catharina M Mulders-Manders, Chantal P Bleeker-Rovers, Wim J G Oyen
Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3°C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory investigations. The differential diagnosis of FUO can be subdivided in four categories: infections, malignancies, noninfectious inflammatory diseases, and miscellaneous causes. In most cases of FUO, there is an uncommon presentation of a common disease. FDG-PET/CT is a sensitive diagnostic technique for the evaluation of FUO by facilitating anatomical localization of focally increased FDG uptake, thereby guiding further diagnostic tests to achieve a final diagnosis...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452275/a-laser-activated-multifunctional-targeted-nanoagent-for-imaging-and-gene-therapy-in-a-mouse-xenograft-model-with-retinoblastoma-y79-cells
#7
Mingxing Wu, Haibo Xiong, Hongmi Zou, Meng Li, Pan Li, Yu Zhou, Yan Xu, Jia Jian, Fengqiu Liu, Hongyun Zhao, Zhigang Wang, Xiyuan Zhou
Retinoblastoma (RB) is the most common intraocular malignancy of childhood that urgently needs early detection and effective therapy methods. The use of nanosized gene delivery systems is appealing because of their highly adjustable structure to carry both therapeutic and imaging agents. Herein, we report a folic acid (FA)-modified phase-changeable cationic nanoparticle encapsulating liquid perfluoropentane (PFP) and indocyanine green (ICG) (FA-CN-PFP-ICG, FCNPI) with good plasmid DNA (pDNA) carrying capacity, favorable biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, enhanced gene transfection efficiency and therapeutic effect...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451774/organic-semiconducting-photoacoustic-nanodroplets-for-laser-activatable-ultrasound-imaging-and-combinational-cancer-therapy
#8
Wei Tang, Zhen Yang, Sheng Wang, Zhantong Wang, Jibin Song, Guocan Yu, Wenpei Fan, Yunlu Dai, Jingjing Wang, Lingling Shan, Gang Niu, Quli Fan, Xiaoyuan Chen
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potentials in applications in medical imaging. Development of PA/US dual-contrast agents with high contrast and excellent biocompatible is of great interest. Herein, an organic semiconducting photoacoustic nanodroplet, PS-PDI-PAnD, is developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet with a photoabsorber and photoacoustic agent of perylene diimide (PDI) molecules and co-encapsulating the droplet with photosensitizers of ZnF16Pc molecules...
February 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451453/trapped-ventricle-after-laser-ablation-of-a-subependymal-giant-cell-astrocytoma-complicated-by-intraventricular-gadolinium-extravasation-case-report
#9
Michael Karsy, Daxa M Patel, Robert J Bollo
Magnetic resonance imaging-guided stereotactic laser ablation of intracranial targets, including brain tumors, has expanded dramatically over the past decade, but there have been few reports of complications, especially those occurring in a delayed fashion. Laser ablation of subependymal giant cell astrocytomas (SEGAs) is an attractive alternative to maintenance immunotherapy in some children with tuberous sclerosis complex (TSC); however, the effect of treatment on disease progression and the nature and frequency of potential complications remains largely unknown...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451317/ultrasound-guided-microinvasive-carpal-tunnel-release-using-a-novel-retractable-needle-mounted-blade-a-cadaveric-study
#10
Peter D Hebbard, Andrew I T Hebbard, Janos Tomka, Richard Appleyard
Ultrasound (US)-guided microinvasive procedures are defined as those performed via needles without notable scarring. Ten cadaver hands underwent US-guided microinvasive carpal tunnel release using a novel needle-based tool, the micro i-Blade (Summit Medical Products, Inc, Sandy, UT). A US-imaged landmark, the inflexion point of the ligaments distal to the hook of the hamate, was used to position the distal extent of the cut. The transverse carpal ligament was successfully released in all hands without damage to nerves or arteries...
February 16, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29451130/intrinsic-optical-signal-imaging-of-the-blood-volume-changes-is-sufficient-for-mapping-the-resting-state-functional-connectivity-in-the-rodent-cortex
#11
Sreekanth Kura, Hongyu Xie, Buyin Fu, Cenk Ayata, David A Boas, Sava Sakadzic
OBJECTIVE: Resting state functional connectivity (RSFC) allows the study of functional organization in normal and diseased brain by measuring the spontaneous brain activity generated under resting conditions. Intrinsic optical signal imaging (IOSI) based on multiple illumination wavelengths has been used successfully to compute RSFC maps in animal studies. The IOSI setup complexity would be greatly reduced if only a single wavelength can be used to obtain comparable RSFC maps. APPROACH: We used anesthetized mice and performed various comparisons between the RSFC maps based on single wavelength as well as oxy-, deoxy- and total hemoglobin concentration changes...
February 16, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29450654/visualizing-protoporphyrin-ix-formation-in-the-dura-tail-of-meningiomas-by-mass-spectrometry-imaging
#12
Benjamin Brokinkel, Sabrina Kröger, Volker Senner, Astrid Jeibmann, Uwe Karst, Walter Stummer
BACKGROUND: The advantages of 5-aminolevulinacid (5-ALA)-induced fluorescence-guided surgery in meningiomas are increasingly discussed. In this context, despite detectable tumor tissue in histopathologial analyses, no fluorescence was shown at the dura tail using the standard operating microscope. Thus, 5-ALA metabolism in this surgically important site remains unknown but needs to be elucidated when further evaluating indications of fluorescence-guided surgery in meningiomas. METHOD: We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)...
February 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29449761/active-localization-and-tracking-of-needle-and-target-in-robotic-image-guided-intervention-systems
#13
Mark Renfrew, Mark Griswold, M Cenk Çavuşoğlu
This paper describes a framework of algorithms for the active localization and tracking of flexible needles and targets during image-guided percutaneous interventions. The needle and target configurations are tracked by Bayesian filters employing models of the needle and target motions and measurements of the current system state obtained from an intra-operative imaging system which is controlled by an entropy-minimizing active localization algorithm. Versions of the system were built using particle and unscented Kalman filters and their performance was measured using both simulations and hardware experiments with real magnetic resonance imaging data of needle insertions into gel phantoms...
January 2018: Autonomous Robots
https://www.readbyqxmd.com/read/29449656/ultrasound-beam-steering-of-oxygen-nanobubbles-for-enhanced-bladder-cancer-therapy
#14
Pushpak Bhandari, Gloriia Novikova, Craig J Goergen, Joseph Irudayaraj
New intravesical treatment approaches for bladder cancer are needed as currently approved treatments show several side effects and high tumor recurrence rate. Our study used MB49 murine urothelial carcinoma model to evaluate oxygen encapsulated cellulosic nanobubbles as a novel agent for imaging and ultrasound guided drug delivery. In this study, we show that oxygen nanobubbles (ONB) can be propelled (up to 40 mm/s) and precisely guided in vivo to the tumor by an ultrasound beam. Nanobubble velocity can be controlled by altering the power of the ultrasound Doppler beam, while nanobubble direction can be adjusted to different desired angles by altering the angle of the beam...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449447/tracers-for-fluorescence-guided-surgery-how-elongation-of-the-polymethine-chain-in-cyanine-dyes-alters-the-pharmacokinetics-of-a-bimodal-c-rgdyk-tracer
#15
Tessa Buckle, Danny M van Willigen, Silvia J Spa, Albertus W Hensbergen, Steffen van der Wal, Clarize M de Korne, Mick M Welling, Henk G van der Poel, James C H Hardwick, Fijs W B van Leeuwen
Objectives: The potential of (receptor-mediated) fluorescence-based image-guided surgery tracers is generally linked to the near-infrared emission profile and good manufacturing production (GMP) availability of fluorescent dyes. Surprisingly, little is known about the critical interaction between the structural composition of the dye and the pharmacokinetics of the tracers. In this study, a bimodal/hybrid tracer design was used to systematically and quantitatively evaluate the influence of elongation of the polymethine chain in a fluorescent cyanine (Cy) dye on the imaging potential of a targeted (RGD-based) tracer...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29449282/a-patient-dose-reduction-technique-for-neuroendovascular-image-guided-interventions-image-quality-comparison-study
#16
A Sonig, S V Setlur Nagesh, V S Fennell, S Gandhi, L Rangel-Castilla, C N Ionita, K V Snyder, L N Hopkins, D R Bednarek, S Rudin, A H Siddiqui, E I Levy
BACKGROUND AND PURPOSE: The ROI-dose-reduced intervention technique represents an extension of ROI fluoroscopy combining x-ray entrance skin dose reduction with spatially different recursive temporal filtering to reduce excessive image noise in the dose-reduced periphery in real-time. The aim of our study was to compare the image quality of simulated neurointerventions with regular and reduced radiation doses using a standard flat panel detector system. MATERIALS AND METHODS: Ten 3D-printed intracranial aneurysm models were generated on the basis of a single patient vasculature derived from intracranial DSA and CTA...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29447260/optimal-dose-reduction-algorithm-using-an-attenuation-based-tube-current-modulation-method-for-cone-beam-ct-imaging
#17
Kihong Son, Jieun Chang, Hoyeon Lee, Changhwan Kim, Taewon Lee, Seungryong Cho, Sohyun Park, Jin Sung Kim
To reduce the radiation dose given to patients, a tube current modulation (TCM) method has been widely used in diagnostic CT systems. However, the TCM method has not yet been applied to a kV-CBCT system on a LINAC machine. The purpose of this study is to investigate if a TCM method would be desirable in a kV-CBCT system for image-guided radiation therapy (IGRT) or not. We have developed an attenuation-based TCM method using prior knowledge from planning CT images of patients. The TCM method can provide optimized dose reductions without degrading image quality for kV-CBCT imaging...
2018: PloS One
https://www.readbyqxmd.com/read/29447082/radiologic-measurement-of-brain-swelling-in-patients-with-large-hemispheric-infarctions-during-targeted-temperature-management
#18
Won Joo Jeong, Jae Seung Bang, Kyu Sun Yum, Sangkil Lee, Inyoung Chung, O-Ki Kwon, Chang Wan Oh, Beom Joon Kim, Hee-Joon Bae, Moon-Ku Han
Brain herniation is most often the result of severe brain swelling and can rapidly lead to death or brain death. We retrospectively identified radiologic indicators to evaluate the effects of targeted temperature management (TTM) on the extent of cerebral edema and determine the cutoff values that best predict TTM outcomes in patients with large hemispheric infarction. We retrospectively reviewed brain computed tomography (CT) scans of 21 patients with large hemispheric infarctions, who were treated with TTM...
February 15, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29446726/metal-organic-framework-mof-based-nanomaterials-for-biomedical-applications
#19
Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Baohong Li, Jianqiang Liu
Metal-organic frameworks (MOFs) are compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers (CPs), with the special feature that they are often porous. The organic ligands are sometimes referred to as second building structs. The new porous materials have paid great attention because of the variety of advantages such as tunable components, structural diversity, high loading performance and favorable biodegradability...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29446670/diagnostic-performance-of-margin-features-in-thyroid-nodules-in-prediction-of-malignancy
#20
Sean M Siebert, Adam J Gomez, Tie Liang, Ali M Tahvildari, Terry S Desser, R Brooke Jeffrey, Aya Kamaya
OBJECTIVE: The purpose of this study was to evaluate thyroid nodule margins for specific morphologic features and determine the diagnostic performance of these features in differentiating papillary carcinoma from benign thyroid nodules. MATERIALS AND METHODS: Nodules measuring 1-3 cm in largest diameter that had been evaluated with high-resolution ultrasound (12-18 MHz) and ultrasound-guided biopsy with definitive pathologic diagnosis were analyzed. Three blinded board-certified readers evaluated high-resolution images of each nodule for jagged edges, lobulated borders, and curved borders along their margins...
February 15, 2018: AJR. American Journal of Roentgenology
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