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https://www.readbyqxmd.com/read/28324908/-magnetic-sentinel-lymph-node-detection-in-prostate-cancer-after-intraprostatic-injection-of-superparamagnetic-iron-oxide-nanoparticles
#1
Alexander Winter, Svenja Engels, Tobias Kowald, Tina Susanne Paulo, Holger Gerullis, Ajay Chavan, Friedhelm Wawroschek
In prostate cancer, reliable information about the lymph node status is of great importance for accurate staging and the optimal planning of treatment. Despite recent advances in imaging, the histological detection of metastases, or pelvic lymphadenectomy (PLND), continues to be the most reliable method for lymph node staging in clinically localised prostate cancer, especially as this procedure enables the detection of small or micrometastases. Radioisotope-guided sentinel PLND (sPLND) demonstrates high sensitivity in the detection of lymph node metastases as well as low morbidity in prostate cancer because of the targeted removal of a relatively small number of lymph nodes...
March 21, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28324873/endobronchial-ultrasound-elastography-for-evaluation-of-intrathoracic-lymph-nodes-a-pilot-study
#2
Jiayuan Sun, Xiaoxuan Zheng, Xiaowei Mao, Lei Wang, Hongkai Xiong, Felix J F Herth, Baohui Han
BACKGROUND: Endobronchial ultrasound (EBUS) elastography is a new imaging procedure for describing the elasticity of intrathoracic lesions and providing important additional diagnostic information. OBJECTIVES: The aim of this study was to utilize the feasibility of qualitative and quantitative methods to evaluate the ability of EBUS elastography to differentiate between benign and malignant mediastinal and hilar lymph nodes (LNs) during EBUS-guided transbronchial needle aspiration (EBUS-TBNA)...
March 22, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#3
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28324601/two-photon-intravital-microscopy-animal-preparation-protocol-to-study-cellular-dynamics-in-pathogenesis
#4
Erinke van Grinsven, Chloé Prunier, Nienke Vrisekoop, Laila Ritsma
Two-photon intravital microscopy (2P-IVM) is an advanced imaging platform that allows the visualization of dynamic processes at subcellular resolution in vivo. Dynamic processes like cell migration, cell proliferation, cell-cell interactions, and cell signaling have an interactive character and occur in complex environments. Hence, it is of pivotal importance to study these processes in living animals, using for example 2P-IVM. 2P-IVM can be performed on a variety of tissues, from the skin of the animal to internal organs, and a variety of methods can be utilized to perform 2P-IVM on these tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323730/transesophageal-bronchoscopic-ultrasound-guided-fine-needle-aspiration-for-metastatic-vertebral-body-lesion
#5
Masahide Oki, Hideo Saka, Shu Ichihara, Suzuko Moritani
Malignant neoplasms frequently cause vertebral metastases. Traditionally, either image-guided percutaneous biopsy or open biopsy has been performed for sampling specimens for the definitive diagnosis. We herein report a case with suspected multiple metastases but unknown primary, who underwent endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lymph nodes with negative results by rapid onsite cytologic evaluation, followed by the transesophageal approach with the ultrasound bronchoscope for the vertebral body lesion at the same setting that provided a definitive diagnosis of metastatic hepatocellular carcinoma...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28323638/fast-lesion-mapping-during-hifu-treatment-using-harmonic-motion-imaging-guided-focused-ultrasound-hmigfus-in-vitro-and-in-vivo
#6
Yang Han, Shutao Wang, Thomas Payen, Elisa Konofagou
The successful clinical application of high intensity focused ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic motion imaging guided focused ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monitoring, rendering it potentially more sensitive to lesion development. Our group has shown that predicting the lesion location based on the radiation force-excited region is feasible during HMIgFUS...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28323410/zno-quantum-dots-decorated-zn2sno4-nanowire-heterojunction-photodetectors-with-drastic-performance-enhancement-and-flexible-ultraviolet-image-sensors
#7
Ludong Li, Leilei Gu, Zheng Lou, Zhiyong Fan, Guozhen Shen
Here we report fabrication of high-performance ultraviolet photodetectors based on a unique heterojunction device structure in which ZnO quantum dots were used to decorate Zn2SnO4 nanowires. Systematic investigations have shown their ultrahigh light-to-dark current ratio (up to 6.8 × 104), specific detectivity (up to 9.0×1017 Jones), photoconductive gain (up to 1.1 × 107), fast response, and excellent stability. Compared with a pristine Zn2SnO4 nanowire, a quantum dots decorated nanowire demonstrated about 10 times higher photocurrent and responsivity...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28323405/oxygen-vacancy-enables-markedly-enhanced-magnetic-resonance-imaging-guided-photothermal-therapy-of-a-gd3-doped-contrast-agent
#8
Dalong Ni, Jiawen Zhang, Jing Wang, Ping Hu, Yingying Jin, Zhongmin Tang, Zhenwei Yao, Wenbo Bu, Jianlin Shi
The Gd3+-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r1 value. Such a strategy is verified on oxygen-deficient PEG-NaxGdWO3 nanorods, which exhibit remarkable r1 value up to 80 mM-1s-1 (at 0...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28320182/axial-mr-diffusion-tensor-imaging-and-tractography-in-clinical-diagnosed-and-pathology-confirmed-cervical-spinal-cord-astrocytoma
#9
Mangsuo Zhao, Bingxin Shi, Tuoyu Chen, Yuqi Zhang, Tongchao Geng, Liyan Qiao, Mingjie Zhang, Le He, Huancong Zuo, Guihuai Wang
OBJECTIVE: To evaluate the diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) features of cervical spinal cord astrocytoma. METHODS: Eleven patients with cervical spinal cord astrocytomas and 10 healthy volunteers were recruited in this study. Conventional magnetic resonance imaging (MRI) and axial DTI were performed on a 3.0T MRI system. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values for the lesions were measured...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319168/targeting-chronic-cardiac-remodeling-with-cardiac-progenitor-cells-in-a-murine-model-of-ischemia-reperfusion-injury
#10
Janine C Deddens, Dries A Feyen, Peter-Paul Zwetsloot, Maike A Brans, Sailay Siddiqi, Linda W van Laake, Pieter A Doevendans, Joost P Sluijter
BACKGROUND: Translational failure for cardiovascular disease is a substantial problem involving both high research costs and an ongoing lack of novel treatment modalities. Despite the progress already made, cell therapy for chronic heart failure in the clinical setting is still hampered by poor translation. We used a murine model of chronic ischemia/reperfusion injury to examine the effect of minimally invasive application of cardiac progenitor cells (CPC) in cardiac remodeling and to improve clinical translation...
2017: PloS One
https://www.readbyqxmd.com/read/28319023/isolated-bilateral-simplex-ureteric-ectopia-bladder-capacity-as-an-indicator-of-continence-outcome
#11
Vasilis Stavrinides, Paul Charlesworth, Dan Wood, Divyesh Desai, Abraham Cherian, Imran Mushtaq, Peter Cuckow, Naima Smeulders
INTRODUCTION: Isolated bilateral simplex ectopic ureters (BSEUs) are rare but pose a therapeutic challenge: ureteric reimplantation alone does not accomplish continence in all. Identifying the patients needing additional procedures for continence early could prevent multiple operations. OBJECTIVE: Potential preoperative indicators for postoperative continence are explored in eight BSEU girls without cloacal, anorectal, or spinal anomalies. STUDY DESIGN: With institutional approval, all patients with BSEU between 1985 and 2012 were retrospectively reviewed...
March 6, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28318915/computer-assisted-positioning-of-the-proximal-segment-after-sagittal-split-osteotomy-of-the-mandible-preclinical-investigation-of-a-novel-electromagnetic-navigation-system
#12
Igor Nova, Sebastian Kallus, Moritz Berger, Oliver Ristow, Urs Eisenmann, Christian Freudlsperger, Jürgen Hoffmann, Hartmut Dickhaus
INTRODUCTION: Modifications of the temporomandibular joint position after mandible osteotomy are reluctantly accepted in orthognathic surgery. To tackle this problem, we developed a new navigation system using miniaturized electromagnetic sensors. Our imageless navigation approach is therefore optimized to avoid complications of previously proposed optical approaches such as the interference with established surgical procedures and the line of sight problem. MATERIAL AND METHODS: High oblique sagittal split osteotomies were performed on 6 plastic skull mandibles in a laboratory under conditions comparable to the operating theatre...
February 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318889/non-invasive-liver-ablation-using-histotripsy-preclinical-safety-study-in-an-in%C3%A2-vivo-porcine-model
#13
Eli Vlaisavljevich, Gabe Owens, Jonathan Lundt, Dejan Teofilovic, Kimberly Ives, Alexander Duryea, Jim Bertolina, Theodore H Welling, Zhen Xu
This study investigates the safety profile for use of histotripsy, a non-invasive ultrasonic ablation method currently being developed for the treatment of liver cancer, for liver ablation in an in vivo porcine model. Histotripsy treatments were applied to the liver and hepatic veins of 22 porcine subjects, with half of the subjects receiving systemic heparinization. Vital signs (heart rate, blood pressure, temperature, electrocardiogram and SpO2) were monitored throughout the procedure and for 1 h post-treatment...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28318307/stress-socializing-and-other-motivations-for-smoking-among-the-lesbian-gay-bisexual-transgender-and-queer-community-in-new-york-city
#14
Deanna P Jannat-Khah, LeConté J Dill, Simone A Reynolds, Michael A Joseph
PURPOSE: This study contributes to the emerging literature on lesbian, gay, bisexual, transgendered, and queer (LGBTQ) health disparities and tobacco use by examining the motivations for smoking among the New York City (NYC) LGBTQ population. APPROACH: We used grounded theory and blended methods from 3 grounded theorists-Strauss, Corbin, and Charmaz-for data collection, coding, and analysis. SETTING: NYC has extensive legislation to prevent smoking; however, the current smoking prevalence of homosexuals is double that of heterosexuals...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28317915/deep-brain-imaging-via-epi-fluorescence-computational-cannula-microscopy
#15
Ganghun Kim, Naveen Nagarajan, Elissa Pastuzyn, Kyle Jenks, Mario Capecchi, Jason Shepherd, Rajesh Menon
Here we demonstrate widefield (field diameter = 200 μm) fluorescence microscopy and video imaging inside the rodent brain at a depth of 2 mm using a simple surgical glass needle (cannula) of diameter 0.22 mm as the primary optical element. The cannula guides excitation light into the brain and the fluorescence signal out of the brain. Concomitant image-processing algorithms are utilized to convert the spatially scrambled images into fluorescent images and video. The small size of the cannula enables minimally invasive imaging, while the long length (>2 mm) allow for deep-brain imaging with no additional complexity in the optical system...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317152/-68-ga-psma-pet-for-radiation-treatment-planning-in-prostate-cancer-recurrences-after-surgery-individualized-medicine-or-new-standard-in-salvage-treatment
#16
Gregor Habl, Katharina Sauter, Kilian Schiller, Sabrina Dewes, Tobias Maurer, Matthias Eiber, Stephanie E Combs
BACKGROUND: (68) Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving (68) Ga-PSMA-PET imaging before salvage radiotherapy (RT). METHODS AND MATERIALS: In this study, 100 patients with biochemical failure after RP± prior RT who underwent (68) Ga-PSMA PET/CT or PET/MRI were evaluated undergoing salvage RT in our department...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28317125/referenceless-magnetic-resonance-temperature-imaging-using-gaussian-process-modeling
#17
Joshua P Yung, David Fuentes, Christopher J MacLellan, Florian Maier, Yannis Liapis, John D Hazle, R Jason Stafford
PURPOSE: During magnetic resonance (MR)-guided thermal therapies, water proton resonance frequency shift (PRFS) based MR temperature imaging can quantitatively monitor tissue temperature changes. It is widely known that the PRFS technique is easily perturbed by tissue motion, tissue susceptibility changes, magnetic field drift, and modality-dependent applicator induced artifacts. Here a referenceless Gaussian process modeling (GPM) based estimation of the PRFS is investigated as a methodology to mitigate unwanted background field changes...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28316992/a-combined-random-forests-and-active-contour-model-approach-for-fully-automatic-segmentation-of-the-left-atrium-in-volumetric-mri
#18
Chao Ma, Gongning Luo, Kuanquan Wang
Segmentation of the left atrium (LA) from cardiac magnetic resonance imaging (MRI) datasets is of great importance for image guided atrial fibrillation ablation, LA fibrosis quantification, and cardiac biophysical modelling. However, automated LA segmentation from cardiac MRI is challenging due to limited image resolution, considerable variability in anatomical structures across subjects, and dynamic motion of the heart. In this work, we propose a combined random forests (RFs) and active contour model (ACM) approach for fully automatic segmentation of the LA from cardiac volumetric MRI...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28316903/network-guided-transcranial-magnetic-stimulation-for-depression
#19
Marc J Dubin, Conor Liston, Michael A Avissar, Irena Llieva, Faith M Gunning
PURPOSE OF REVIEW: First, we will identify candidate predictive biomarkers of antidepressant response of TMS based on the neuroimaging literature. Next, we will review the effects of TMS on networks involved in depression. Finally, we will discuss ways in which our current understanding of network engagement by TMS may be used to optimize its antidepressant effect. RECENT FINDINGS: The past few years has seen significant interest in the antidepressant mechanisms of TMS...
March 2017: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/28316224/-relief-effect-of-ct-guided-125-i-seed-implantation-on-patients-with-spinal-and-paraspinal-osteolytic-metastatic-tumors
#20
H Huang, F S Li, L Wang, Z G Du, S N Xu
Objective: To evaluate the clinical value of computed tomography (CT)-guided (125)I seed implantation in the treatment of patients with spinal and/or paraspinal osteolytic metastatic tumors. Methods: The radiation dose distribution was planned for 27 patients with 35 spinal and paraspinal osteolytic metastatic tumors by a treatment planning system (TPS). CT-guided (125)I seed implantation was carried out in the patients, and the quality of treatment was evaluated based on CT-imaging follow-up. Results: All the 27 patients underwent CT-guided (125)I seed implantation successfully...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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