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https://www.readbyqxmd.com/read/29050358/state-of-the-art-considerations-in-small-cell-lung-cancer-brain-metastases
#1
REVIEW
Rimas V Lukas, Vinai Gondi, David O Kamson, Priya Kumthekar, Ravi Salgia
BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049837/clinical-application-of-projection-mapping-technology-for-surgical-resection-of-lung-metastasis
#2
Toyofumi F Chen-Yoshikawa, Etsuro Hatano, Atsushi Yoshizawa, Hiroshi Date
Indocyanine green fluorescent image-guided surgery was developed to identify primary and metastatic nodules of various malignancies. However, currently, surgeons need to identify the fluorescent image on a monitor, which impedes surgical procedures. Herein, we developed a novel projection mapping device that can cast the real-time fluorescent image onto the surface of the targeted organ. We performed surgical resection of a lung metastasis of hepatoblastoma using this technique. The projection mapping technique clearly detected the pulmonary lesion, and no other lesions were identified in the ipsilateral thorax...
July 28, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049798/near-infrared-fluorescence-guided-thoracoscopic-surgical-intervention-for-postoperative-chylothorax
#3
Feng Yang, Jian Zhou, Hao Li, Fan Yang, Rongxin Xiao, Chongwei Chi, Jie Tian, Jun Wang
OBJECTIVES: Chylothorax is an infrequent but relatively serious complication after lung cancer surgery. Finding the leakage site and identifying the thoracic duct (TD) are the key points of surgical intervention for chylothorax. In this study, for the first time, we demonstrated near-infrared fluorescence imaging with indocyanine green (ICG) in video-assisted thoracoscopic surgery (VATS) intervention for chylothorax in humans. METHODS: This study included 4 patients diagnosed with chylothorax after lung cancer surgery who underwent VATS intervention; 0...
September 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049713/clampless-myocardial-revascularization-on-a-healed-iatrogenic-aortic-dissection
#4
Jean-David Blossier, Fanny Gabrysz-Forget, Victor-Xavier Tadros, Louis P Perrault
Iatrogenic aortic dissection is an infrequent complication of cardiac catheterization (0.03-0.06%) associated with up to 19% of mortality at 30 days. It was reported to mostly occur when using a 6-Fr guiding catheter to cannulate the right coronary artery. This life-threatening complication usually requires early surgical management and close imaging monitoring and control of systolic blood pressure. This case report describes a patient with iatrogenic aortic dissection during cardiac catheterization in symptomatic coronary artery disease...
September 23, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049613/hybrid-operating-room-dyna-computed-tomography-combined-image-guided-electromagnetic-navigation-bronchoscopy-dye-marking-and-hookwire-localization-video-assisted-thoracic-surgery-metastasectomy
#5
Calvin S H Ng, Cheuk Man Chu, Cheuk Kin Lo, Rainbow W H Lau
Hybrid operating room Dyna-computed tomography imaging is increasingly recognized as an important adjunct for management of small pulmonary lesions, either for biopsy or for localization to guide surgical resection. We describe for the first time the combined hybrid operating room Dyna-computed tomography image-guided electromagnetic navigation bronchoscopy dye marking and hookwire localization approach to localize multiple sub-centimetre nodules for video-assisted thoracic surgery metastasectomy. Furthermore, such complex set of procedures can be safely and effectively performed within one operating environment, maximizing work efficiency and minimizing the potential for complications...
September 27, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048474/transinnominate-approach-for-transcatheter-aortic-valve-replacement-single-centre-experience-of-minimally-invasive-alternative-access
#6
Luigi Pirelli, Jacob S Scheinerman, Derek R Brinster, Nirav C Patel, Alaeldin Eltom, Jonathan M Hemli, Chad A Kliger
OBJECTIVES: Iliofemoral arteries have been the preferred access for transcatheter aortic valve replacement (TAVR). When these arteries are too small, calcified or tortuous, an alternative access must be considered. Transinnominate (TI) access is an extrathoracic approach that does not require manipulation of major neurovascular structures or the apex. The aim of this study is to evaluate the efficacy and safety of TI TAVR as an alternative access in patients with severe aortic stenosis not amenable to a transfemoral approach...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29047957/diffuse-optical-localization-of-blood-vessels-and-3d-printing-for-guiding-oral-surgery
#7
Brian Z Bentz, Timothy C Wu, Vaibhav Gaind, Kevin J Webb
Diffuse optical imaging through centimeters of tissue has emerged as a powerful tool in biomedical research. However, applications in the operating theater have been limited in part due to data set requirements and computational burden. We present an approach that uses a small number of optical source-detector pairs that allows for the fast localization of arteries in the roof of the mouth and has the potential to reduce complications during oral surgery. The arteries are modeled as multiple-point absorbers, allowing localization of their complex shapes...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047748/error-analysis-of-large-diameter-subaperture-stitching-fresnel-diffractive-elements
#8
Haolin Zhang, Hua Liu, Wenbin Xu, Angel Lizana, Xiaoduo Wang, Zhenwu Lu
Image quality is dramatically influenced by the stitching errors in a large-diameter stitching Fresnel lens. In this paper, we studied three kinds of errors that can cover all stitching errors in a Cornwell deployed Fresnel lens. In particular, a 300-mm-diameter, three-belt deployed Fresnel diffractive lens was simulated to investigate the stitching error. The star test and the resolution board test experiments were conducted, and the experimental results fit the simulation results. This means that our error analysis theory and simulation method are efficient and accurate and could be used to guide future super-large aperture stitching...
September 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047579/experimental-power-spectral-density-analysis-for-mid-to-high-spatial-frequency-surface-error-control
#9
Javier Del Hoyo, Heejoo Choi, James H Burge, Geon-Hee Kim, Dae Wook Kim
The control of surface errors as a function of spatial frequency is critical during the fabrication of modern optical systems. A large-scale surface figure error is controlled by a guided removal process, such as computer-controlled optical surfacing. Smaller-scale surface errors are controlled by polishing process parameters. Surface errors of only a few millimeters may degrade the performance of an optical system, causing background noise from scattered light and reducing imaging contrast for large optical systems...
June 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047500/step-by-step-guide-to-reduce-spatial-coherence-of-laser-light-using-a-rotating-ground-glass-diffuser
#10
Tim Stangner, Hanqing Zhang, Tobias Dahlberg, Krister Wiklund, Magnus Andersson
Wide field-of-view imaging of fast processes in a microscope requires high light intensities motivating the use of lasers as light sources. However, due to their long spatial coherence length, lasers are inappropriate for such applications, as they produce coherent noise and parasitic reflections, such as speckle, degrading image quality. Therefore, we provide a step-by-step guide for constructing a speckle-free and high-contrast laser illumination setup using a rotating ground glass diffuser driven by a stepper motor...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047477/how-daylight-influences-high-order-chromatic-descriptors-in-natural-images
#11
Juan Ojeda, Juan Luis Nieves, Javier Romero
Despite the global and local daylight changes naturally occurring in natural scenes, the human visual system usually adapts quite well to those changes, developing a stable color perception. Nevertheless, the influence of daylight in modeling natural image statistics is not fully understood and has received little attention. The aim of this work was to analyze the influence of daylight changes in different high-order chromatic descriptors (i.e., color volume, color gamut, and number of discernible colors) derived from 350 color images, which were rendered under 108 natural illuminants with Correlated Color Temperatures (CCT) from 2735 to 25,889 K...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047455/a-monte-carlo-study-to-assess-the-effect-of-1-5-t-magnetic-fields-on-the-overall-robustness-of-pencil-beam-scanning-proton-radiotherapy-plans-for-prostate-cancer
#12
Christopher Kurz, Guillaume Landry, Andreas F Resch, George Dedes, Florian Kamp, Ute Ganswindt, Claus Belka, Bas W Raaymakers, Katia Parodi
Combining magnetic-resonance imaging (MRI) and proton therapy (PT) using pencil-beam scanning (PBS) may improve image-guided radiotherapy. We aimed at assessing the impact of a magnetic field on PBS-PT plan quality and robustness. Specifically, the robustness against anatomical changes and positioning errors in an MRI-guided scenario with a 30 cm radius 1.5 T magnetic field was studied for prostate PT. Five prostate cancer patients with three consecutive CT images (CT1-3) were considered. Single-field uniform dose PBS-PT plans were generated on the segmented CT1 with Monte-Carlo-based treatment planning software for inverse optimization...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29047182/nanoscale-metal-organic-frames-decorated-with-graphene-oxide-for-magnetic-resonance-imaging-guided-photothermal-therapy
#13
Jing Meng, Xiujin Chen, Yang Tian, Zhongfeng Li, Qingfeng Zheng
Imaging-guided photothermal therapy provides an attractive way to eliminate the risk of cancer. In this paper, we prepared a composite material by nanoscale metal-organic frames (NMOFs) and graphene oxide (GO) for the potential use of photothermal therapy (PTT) of tumor guided with magnetic resonance imaging (MRI). The NMOFs containing Fe3+ were prefabricated with an octahedral morphology by a solvothermal reaction, offering strong T2-weighted contrast in MRI. Then the NMOFs were decorated with GO nanosheets, which were good at photothermal function...
October 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29046790/intraluminal-rectal-cancer-metastasis-to-the-small-bowel-an-extremely-rare-case-report
#14
Paraskevas Stamopoulos, Nikolaos Machairas, Stylianos Kykalos, Afrodite Nonni, Gregory Kouraklis, Georgios C Sotiropoulos
Prolonged survival in patients suffering from colorectal cancer (CRC) may lead to the emergence of rare metastatic sites that are not well-documented in the literature. We herein describe a very rare case of an intraluminal small intestinal metastasis in a patient with previously resected CRC. A 71-year-old Caucasian male patient with a history of rectosigmoid junction cancer was initially treated with anterior resection. The tumor was classified as pT3pN0 (0/26) M0, stage II. Eighteen months after the primary surgery, local recurrence was detected in the presacral region, and the patient received combined image-guided radiotherapy and chemotherapy...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046623/biocompatible-d-a-semiconducting-polymer-nanoparticle-with-light-harvesting-unit-for-highly-effective-photoacoustic-imaging-guided-photothermal-therapy
#15
Jinfeng Zhang, Caixia Yang, Rui Zhang, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Shih-Hao Peng, Xiaoyuan Chen, Gang Liu, Chain-Shu Hsu, Chun-Sing Lee
The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent...
April 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29046084/penetrating-neck-injuries-a-guide-to-evaluation-and-management
#16
J L Nowicki, B Stew, E Ooi
Introduction Penetrating neck injury is a relatively uncommon trauma presentation with the potential for significant morbidity and possible mortality. There are no international consensus guidelines on penetrating neck injury management and published reviews tend to focus on traditional zonal approaches. Recent improvements in imaging modalities have altered the way in which penetrating neck injuries are now best approached with a more conservative stance. A literature review was completed to provide clinicians with a current practice guideline for evaluation and management of penetrating neck injuries...
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#17
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045877/self-organization-of-ftsz-polymers-in-solution-reveals-spacer-role-of-the-disordered-c-terminal-tail
#18
Sonia Huecas, Erney Ramírez-Aportela, Albert Vergoñós, Rafael Núñez-Ramírez, Oscar Llorca, J Fernando Díaz, David Juan-Rodríguez, María A Oliva, Patricia Castellen, José M Andreu
FtsZ is a self-assembling GTPase that forms, below the inner membrane, the mid-cell Z-ring guiding bacterial division. FtsZ monomers polymerize head to tail forming tubulin-like dynamic protofilaments, whose organization in the Z-ring is an unresolved problem. Rather than forming a well-defined structure, FtsZ protofilaments laterally associate in vitro into polymorphic condensates typically imaged on surfaces. We describe here nanoscale self-organizing properties of FtsZ assemblies in solution that underlie Z-ring assembly, employing time-resolved x-ray scattering and cryo-electron microscopy...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045698/remission-in-psoriatic-arthritis-where-are-we-now
#19
Laura C Coates, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten De Wit, Oliver FitzGerald, Tore K Kvien, Rik Lories, Philip Mease, Peter Nash, Georg Schett, Enrique R Soriano, Paul Emery
Advances in treatments and treatment strategies for PsA have led to many patients responding well to management of their disease, and targeting remission as a treatment goal is now a possibility. Treat to target is a strategy aimed at maximizing benefit, irrespective of the type of medication used, by monitoring disease activity and using it to guide therapy. The measurement of response to treatment has been the subject of wide discussions among experts for some time, and many instruments exist. Comparisons of the different measures and their different strengths and weaknesses is ongoing...
October 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045237/monoplane-3d-2d-registration-of-cerebral-angiograms-based-on-multi-objective-stratified-optimization
#20
Timur Aksoy, Ziga Spiclin, Franjo Pernus, Gozde Unal
Registration of 3D pre-interventional to 2D intra-interventional medical images has an increasingly important role in surgical planning, navigation and treatment, because it enables the physician to co-locate depth information given by pre-interventional 3D images with the live information in intra-interventional 2D images such as X-ray. Most tasks during image-guided interventions are carried out under a monoplane X-ray, which is a highly ill-posed problem for state-of-the-art 3D to 2D registration methods...
October 18, 2017: Physics in Medicine and Biology
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