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https://www.readbyqxmd.com/read/28231035/biologically-relevant-heterogeneity-metrics-and-practical-insights
#1
Albert Gough, Andrew M Stern, John Maier, Timothy Lezon, Tong-Ying Shun, Chakra Chennubhotla, Mark E Schurdak, Steven A Haney, D Lansing Taylor
Heterogeneity is a fundamental property of biological systems at all scales that must be addressed in a wide range of biomedical applications, including basic biomedical research, drug discovery, diagnostics, and the implementation of precision medicine. There are a number of published approaches to characterizing heterogeneity in cells in vitro and in tissue sections. However, there are no generally accepted approaches for the detection and quantitation of heterogeneity that can be applied in a relatively high-throughput workflow...
March 2017: SLAS Discov
https://www.readbyqxmd.com/read/28230623/safety-and-accuracy-of-freehand-versus-navigated-iliac-screws-results-from-222-screw-placements
#2
Randall J Hlubek, Kaith K Almefty, David S Xu, Jay D Turner, U Kumar Kakarla
STUDY DESIGN: Retrospective review. OBJECTIVE: To compare the safety and accuracy of the freehand technique versus stereotactic navigation for placement of iliac screws. SUMMARY OF BACKGROUND DATA: Iliac screw fixation is often used to augment lumbosacral reconstruction in advanced spine disease to increase the likelihood of successful arthrodesis. Iliac screws can be placed with image guidance, using either intraoperative fluoroscopy or computed tomography (CT) to guide navigation...
February 22, 2017: Spine
https://www.readbyqxmd.com/read/28230179/crowdsourcing-scoring-of-immunohistochemistry-images-evaluating-performance-of-the-crowd-and-an-automated-computational-method
#3
Humayun Irshad, Eun-Yeong Oh, Daniel Schmolze, Liza M Quintana, Laura Collins, Rulla M Tamimi, Andrew H Beck
The assessment of protein expression in immunohistochemistry (IHC) images provides important diagnostic, prognostic and predictive information for guiding cancer diagnosis and therapy. Manual scoring of IHC images represents a logistical challenge, as the process is labor intensive and time consuming. Since the last decade, computational methods have been developed to enable the application of quantitative methods for the analysis and interpretation of protein expression in IHC images. These methods have not yet replaced manual scoring for the assessment of IHC in the majority of diagnostic laboratories and in many large-scale research studies...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230009/effect-of-heat-sink-on-the-recurrence-of-small-malignant-hepatic-tumors-after-radiofrequency-ablation
#4
Zheng-Yu Lin, Guo-Lin Li, Jin Chen, Zhong-Wu Chen, Yi-Ping Chen, Sun-Zhi Lin
AIMS: The aim of this study was to investigate the effect of heat sink on the recurrence of hepatic malignant tumors <3 cm after percutaneous radiofrequency ablation (RFA). SUBJECTS AND METHODS: This study included 564 hepatic malignant tumors <3 cm in 381 patients. Preoperative images were used to determine whether these tumors were adjacent to vessels, and the diameter of adjacent vessels was measured. RFA was performed computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US) guidance, and postoperative imaging follow-up was then conducted...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229810/ultrasound-of-the-osteoarthritic-joint
#5
REVIEW
Annamaria Iagnocco, Esperanza Naredo
Ultrasound (US) has acquired an increasing role in the assessment of joint and periarticular abnormalities in osteoarthritis (OA). It is able to image a large set of abnormalities in this disease which include both inflammatory and structural changes at different peripheral joint sites and it is helpful in guiding local procedures that can be easily and safely performed with optimal patient's tolerance. US is a feasible imaging modality that has become a bedside procedure in the rheumatology clinical practice, thus filling the gap between clinical and radiographic evaluations of patients with OA...
February 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28228881/urachal-adenocarcinoma-a-rare-case-report
#6
Bo Bao, Muhammed Hatem, Jason K Wong
Urachal carcinoma is a rare and aggressive form of bladder cancer involving the urachus, a fibrous remnant of the allantois that extends from the bladder to the umbilicus. We report this case of a 49-year-old women with primary urachal adenocarcinoma treated with partial cystectomy who relapsed 5 years after surgery with lung metastases. This patient with unremarkable medical history presented with abdominal discomfort and a palpable pelvic mass. Follow-up imaging reveals a large mass on the dome of the bladder extending from the urachus...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228700/osteochondroma-and-spinal-cord-compression-in-a-patient-with-hereditary-multiple-exostoses-a-case-report
#7
Robert J Zoboski
OBJECTIVE: The purpose of this report was to describe the presentation of a patient with hereditary multiple exostoses and thoracic spinal cord compression from an osteochondroma. CLINICAL FEATURES: A 31-year-old female presented to a chiropractic clinic with a history of hereditary multiple exostoses and back pain that had existed since the age of 16 years. She had a past medical history that was remarkable for 3 prior surgeries for mass removal. Examination revealed a left upper midscapular mass with decreased sensation...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28228323/evaluation-of-the-role-of-susceptibility-weighted-imaging-in-thrombolytic-therapy-for-acute-ischemic-stroke
#8
Guangjian Zhao, Ling Sun, Ziran Wang, Liquan Wang, Zhongrong Cheng, Hongyan Lei, Daiqun Yang, Yansen Cui, Shirui Zhang
We inspected low-intensity venous signals and microbleeds in patients with acute ischemic stroke (AIS) using susceptibility-weighted imaging (SWI) before and after administration of within-thrombolytic-time-window thrombolytic therapies, and observed their prognosis and safety, in order to guide individualized thrombolytic therapies. Patients with AIS were divided into groups A or B according to the presence of symmetric or asymmetric veins on SWI, and were re-inspected by SWI after intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA)...
February 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28228308/systematic-review-of-non-invasive-cardiovascular-imaging-in-the-diagnosis-of-constrictive-pericarditis
#9
Sivakumar Ardhanari, Bharath Yarlagadda, Vishal Parikh, Kevin C Dellsperger, Anand Chockalingam, Sudarshan Balla, Senthil Kumar
BACKGROUND: Diagnosis of constrictive pericarditis (CP) can be challenging. It can be nearly impossible to distinguish CP from other causes of right heart failure. Although various imaging modalities help in the diagnosis, no test is definitive. Several reviews have addressed the role of various imaging techniques in the diagnosis of CP but a systematic review has not yet been published. OBJECTIVE: Our intention was to study the ability of various non-invasive imaging modalities to diagnose CP in patients with surgically confirmed disease and to apply our findings to develop a clinically useful diagnostic algorithm...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228249/a-computerised-test-of-perceptual-ability-for-learning-endoscopic-and-laparoscopic-surgery-and-other-image-guided-procedures-score-norms-for-picsor
#10
Patrick Henn, Anthony G Gallagher, Emmeline Nugent, Roddy Cowie, Neal E Seymour, Randy S Haluck, Hazem Hseino, Oscar Traynor, Paul C Neary
BACKGROUND: The aptitude to infer the shape of 3-D structures, such as internal organs from 2-D monitor displays, in image guided endoscopic and laparoscopic procedures varies. We sought both to validate a computer-generated task Pictorial Surface Orientation (PicSOr), which assesses this aptitude, and to identify norm referenced scores. METHODS: 400 subjects (339 surgeons and 61 controls) completed the PicSOr test. 50 subjects completed it again one year afterwards...
February 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28227689/robotic-system-with-multiplex-power-transmission-for-mri-guided-percutaneous-interventions
#11
Yang Wang, Sungmin Kim, Everette C Burdette, Peter Kazanzides, Iulian Iordachita, Yang Wang, Sungmin Kim, Everette C Burdette, Peter Kazanzides, Iulian Iordachita, Sungmin Kim, Peter Kazanzides, Everette C Burdette, Iulian Iordachita, Yang Wang
In minimally invasive prostate percutaneous interventions, Magnetic Resonance Imaging (MRI) compatible robotic assistive systems developed over the years tend to have multiple degrees of freedom (DOF) to accomplish complex surgical tasks. This paper presents a novel design of an MRI-compatible transmission that allows one driving motor to control a multiplexed DOF robot system. The transmission could reduce the number of motors in the system, while maintaining the functionality of the system, by controlling each motion sequentially rather than simultaneously...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227684/a-novel-wireless-wearable-fluorescence-image-guided-surgery-system
#12
Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Shixin Jiang, Jinzuo Ye, Kunshan He, Chongwei Chi, Jie Tian, Yamin Mao, Yu An
Segmentectomy using indocyanine green (ICG) has become a primary treatment option to achieve a complete resection and preserve lung function in early-stage lung cancer. However, owing to a lack of appropriate intraoperative imaging systems, it is a huge challenge for surgeons to identify the intersegmental plane during the operation, leading to poor prognosis. Thus, we developed a novel wireless wearable fluorescence image-guided surgery system (LIGHTEN) for fast and accurate identification of intersegmental planes in human patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227662/towards-synergistic-control-of-hands-on-needle-insertion-with-automated-needle-steering-for-mri-guided-prostate-interventions
#13
Marek Wartenberg, Niravkumar Patel, Gang Li, Gregory S Fischer, Marek Wartenberg, Niravkumar Patel, Gang Li, Gregory S Fischer, Niravkumar Patel, Marek Wartenberg, Gregory S Fischer, Gang Li
A significant hurdle of accurate needle tip placement in percutaneous needle-based prostate interventions is unmodeled needle deflection and tissue deformation during insertion. This paper introduces a robotic platform for developing synergistic, cooperatively controlled needle insertion algorithms decoupled from closed-loop image-guided needle steering. Shared control of the surgical workspace through human-robot synergy creates a balance between the accuracy of robotic autonomy while still providing ultimate control of the procedure to the physician...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227412/development-of-a-real-time-lumbar-ultrasound-image-processing-system-for-epidural-needle-entry-site-localization
#14
Yusong Leng, Shuang Yu, Kok Kiong Tan, Philip Tildsley, Alex Tiong Heng Sia, Ban Leong Sng, Yusong Leng, Shuang Yu, Kok Kiong Tan, Philip Tildsley, Alex Tiong Heng Sia, Ban Leong Sng, Yusong Leng, Shuang Yu, Philip Tildsley, Ban Leong Sng, Kok Kiong Tan
A fully-automatic ultrasound image processing system that can determine the needle entry site for epidural anesthesia (EA) in real time is presented in this paper. Neither the knowledge of anesthetists nor additional hardware is required to operate the system, which firstly directs the anesthetists to reach the desired insertion region in the longitudinal view, i.e., lumbar level L3-L4, and then locates the ideal puncture site by instructing the anesthetists to rotate and slightly adjust the position of ultrasound probe...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227380/efficient-rendering-of-digitally-reconstructed-radiographs-on-heterogeneous-computing-architectures-using-central-slice-theorem
#15
Marwan Abdellah, Mohamed Abdallah, Mohamed Alzanati, Ayman Eldeib, Marwan Abdellah, Mohamed Abdallah, Mohamed Alzanati, Ayman Eldeib, Ayman Eldeib, Mohamed Abdallah, Mohamed Alzanati, Marwan Abdellah
Digitally reconstructed radiographs (DRRs) play a significant role in modern clinical radiation therapy. They are used to verify patient alignments during image guided therapies with 2D-3D image registration. The generation of DRRs can be implemented intuitively in O(N(3)) relying on direct volume rendering (DVR) methods, such as ray marching. This complexity imposes certain limitations on the rendering performance if high quality DRR images are needed. Those DRRs can be alternatively generated in the k-space using the central slice theorem in O(N(2)logN)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227379/parallel-generation-of-digitally-reconstructed-radiographs-on-heterogeneous-multi-gpu-workstations
#16
Marwan Abdellah, Asem Abdelaziz, E M B S Eslam Ali, Sherief Abdelaziz, Abdelrahman Sayed, Mohamed I Owis, Ayman Eldeib, Marwan Abdellah, Asem Abdelaziz, E M B S Eslam Ali, Sherief Abdelaziz, Abdelrahman Sayed, Mohamed I Owis, Ayman Eldeib, Sherief Abdelaziz, Mohamed I Owis, Abdelrahman Sayed, Marwan Abdellah, Asem Abdelaziz, Eslam Ali, Ayman Eldeib
The growing importance of three-dimensional radiotherapy treatment has been associated with the active presence of advanced computational workflows that can simulate conventional x-ray films from computed tomography (CT) volumetric data to create digitally reconstructed radiographs (DRR). These simulated x-ray images are used to continuously verify the patient alignment in image-guided therapies with 2D-3D image registration. The present DRR rendering pipelines are quite limited to handle huge imaging stacks generated by recent state-of-the-art CT imaging modalities...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227378/fbp-initialized-few-view-ct-reconstruction-algorithm-using-similar-prior-image-constraint
#17
Weikang Zhang, Jiansen Li, Jianqi Sun, Jun Zhao, Weikang Zhang, Jiansen Li, Jianqi Sun, Jun Zhao, Jiansen Li, Weikang Zhang, Jun Zhao, Jianqi Sun
Few-view CT reconstruction attracts wide attention in the purpose of radiation dose reduction. For analytical algorithm filtered back projection (FBP), the reconstructed image would have extremely severe artifacts. Prior information could be used in few-view CT reconstruction to improve image quality, and similar prior images of the same person could provide much more reliable information. However, in most cases, the previous CT scans might be obtained a long time ago and not much the same as the current one...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227375/motion-invariant-contrast-enhancement-of-optical-imaging-data-in-the-gradient-domain
#18
Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Daniel J Strauss, Alejandro Romero-Santiago, Jacek Szczygielski, Karsten Schwerdtfeger, Philipp Flotho, Lars Haab
Functional optical imaging (OI) of intrinsic signals (like blood oxygenation coupled reflection changes) and of extrinsic properties of voltage sensitive probes (like voltage-sensitive dyes (VSD)) forms a group of neuroimaging techniques that possess up to date highest temporal and spatial resolution on a meso-to macroscopic scale. An inherent problem of OI is a very low signal to noise ratio (SNR), which restricts the recordings to be completely motionless and requires detailed knowledge of the properties of the different noise sources...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227232/itk-snap-an-interactive-tool-for-semi-automatic-segmentation-of-multi-modality-biomedical-images
#19
Paul A Yushkevich, Yang Gao, Guido Gerig, Paul A Yushkevich, Yang Gao, Guido Gerig, Yang Gao, Paul A Yushkevich, Guido Gerig
Obtaining quantitative measures from biomedical images often requires segmentation, i.e., finding and outlining the structures of interest. Multi-modality imaging datasets, in which multiple imaging measures are available at each spatial location, are increasingly common, particularly in MRI. In applications where fully automatic segmentation algorithms are unavailable or fail to perform at desired levels of accuracy, semi-automatic segmentation can be a time-saving alternative to manual segmentation, allowing the human expert to guide segmentation, while minimizing the effort expended by the expert on repetitive tasks that can be automated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227041/deformable-resection-process-map-for-intraoperative-cutting-guides
#20
Megumi Nakao, Kojiro Taura, Tetsuya Matsuda, Megumi Nakao, Kojiro Taura, Tetsuya Matsuda, Megumi Nakao, Kojiro Taura, Tetsuya Matsuda
In this paper, we will introduce the concept of deformable resection process mapping as a time-varying geometric guide for soft tissue tumor resection procedures. The deformable resection process map (RPM) estimates the local appearance of vascular structures after cuts as a novel guide. The RPM can be directly generated from patient-specific medical images using volumetric resampling techniques. Since user input of some cutting points is the only requirement for generating the RPM, the developed software will be directly available for clinical use to preview surgical procedures and intraoperative workflow management without time-consuming setups or additional workloads...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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