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https://www.readbyqxmd.com/read/28110313/framework-for-2d-3d-image-fusion-of-infrared-thermography-with-preoperative-mri
#1
Nico Hoffmann, Florian Weidner, Peter Urban, Tobias Meyer, Christian Schnabel, Yordan Radev, Gabriele Schackert, Uwe Petersohn, Edmund Koch, Stefan Gumhold, Gerald Steiner, Matthias Kirsch
Multimodal medical image fusion combines information of one or more images in order to improve the diagnostic value. While previous applications mainly focus on merging images from computed tomography, magnetic resonance imaging (MRI), ultrasonic and single-photon emission computed tomography, we propose a novel approach for the registration and fusion of preoperative 3D MRI with intraoperative 2D infrared thermography. Image-guided neurosurgeries are based on neuronavigation systems, which further allow us track the position and orientation of arbitrary cameras...
January 23, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28110021/the-application-of-crispr-technology-to-high-content-screening-in-primary-neurons
#2
Ben L Callif, Brian Maunze, Nick L Krueger, Matthew T Simpson, Murray G Blackmore
Axon growth is coordinated by multiple interacting proteins that remain incompletely characterized. High content screening (HCS), in which manipulation of candidate genes is combined with rapid image analysis of phenotypic effects, has emerged as a powerful technique to identify key regulators of axon outgrowth. Here we explore the utility of a genome editing approach referred to as CRISPR (Clustered Regularly Interspersed Palindromic Repeats) for knockout screening in primary neurons. In the CRISPR approach a DNA-cleaving Cas enzyme is guided to genomic target sequences by user-created guide RNA (sgRNA), where it initiates a double-stranded break that ultimately results in frameshift mutation and loss of protein production...
January 18, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28109895/pilot-study-of-the-mirabilis-system-prototype-for-rapid-noninvasive-uterine-fibroid-treatment-using-an-ultrasound-guided-volumetric-shell-ablation-technique
#3
Jessica E Parsons, Michael P H Lau, Patrick J Martin, Joel J Islas Lagos, Juan M Aguilar Aguirre, José G Garza Leal
STUDY OBJECTIVE: The primary objective of this pilot study was to evaluate the safety and acute tissue ablation efficacy of a transabdominal high-intensity focused ultrasound (HIFU) prototype device that uses ultrasound imaging guidance for rapid noninvasive ablation of uterine fibroids. The secondary objective was to assess preliminary fibroid-related symptom improvement and fibroid volume reduction at 3 - 6 months post-treatment in subsets of patients. DESIGN: Multi-center prospective single-arm pilot study (Canadian Task Force Classification II-2) SETTING: University-affiliated teaching hospital and private community hospital PATIENTS: Women with a diagnosis of symptomatic uterine fibroids planning to undergo hysterectomy INTERVENTIONS: Seventy-three (73) women underwent transabdominal ultrasound-guided HIFU treatment using a volumetric ablation technique referred to as 'shell ablation,' in which the HIFU energy is deposited in patterns that partially encapsulate the peripheral region of the targeted fibroid(s)...
January 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28109525/wire-and-needle-potentials-facilitating-transseptal-puncture
#4
Konstantin M Heinroth, Thomas Hartkopf, Alexander Plehn, Joachim Wilhelm, Susanne Unverzagt, Stefan Frantz, Alexander Schirdewan
BACKGROUND: Transseptal puncture for left heart interventions became a routine procedure guided by fluoroscopy and echocardiography. The use of intracardiac potentials derived from the sheath-transseptal-needle/guidewire-combination may provide helpful information to increase safety of this procedure. METHODS AND RESULTS: We recorded the intracardiac potentials from the sheath-transseptal-needle/guidewire-combination during the transseptal puncture procedure in 31 consecutive patients (mean age 67...
January 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28108994/magnetic-resonance-imaging-directed-ultrasound-imaging-of-non-mass-enhancement-in-the-breast-outcomes-and-frequency-of-malignancy
#5
Adrienne R Newburg, Chloe M Chhor, Leng Leng Young Lin, Samantha L Heller, Jennifer Gillman, Hildegard K Toth, Linda Moy
OBJECTIVES: This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. METHODS: From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non-mass enhancing lesions for which follow-up or biopsy was recommended. Retrospective review of the images identified 879 of 918 lesions (96%) meeting criteria for non-mass enhancement...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108488/stimulus-tuned-structure-of-correlated-fmri-activity-in-human-visual-cortex
#6
Jungwon Ryu, Sang-Hun Lee
Processing units are interconnected in the visual system, where a sensory organ and downstream cortical regions communicate through hierarchical connections, and local sites within the regions communicate through horizontal connections. In such networks, neural activities at local sites are likely to influence one another in complex ways and thus are intricately correlated. Recognizing the functional importance of correlated activity in sensory representation, spontaneous activities have been studied via diverse local or global measures in various time scales...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108142/identifying-mronj-affected-bone-with-digital-fusion-of-functional-imaging-fi-and-cone-beam-computed-tomography-cbct-case-reports-and-hypothesis
#7
Gayathri Subramanian, Evelyne Kalyoussef, Meredith Blitz-Goldstein, Jessenia Guerrero, Nasrin Ghesani, Samuel Y P Quek
Surgical debridement of medication-related osteonecrosis of the jaw (MRONJ) lesions is far less predictable than lesion resection. Margins for surgical debridement are guided by surrogate markers of bone viability, such as bleeding and bone fluorescence, which limit debridement to visibly necrotic bone. In contrast, surgical resection is extensive, including a substantial portion of surrounding bone. The concept that the MRONJ lesion is a composite of affected but viable ("compromised") and necrotic bone is supported by histopathological data...
November 28, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28107752/genome-nuclear-lamina-interactions-from-cell-populations-to-single-cells
#8
REVIEW
J Omar Yáñez-Cuna, Bas van Steensel
Lamina-associated domains (LADs) are large genomic regions that interact with the nuclear lamina (NL) and help to guide the spatial folding of chromosomes in the interphase nucleus. LADs have been linked to gene repression and other functions. Recent studies have begun to uncover some of the molecular players that drive LAD-NL interactions. A picture emerges in which DNA sequence, chromatin components and nuclear lamina proteins play an important role. Complementary to this, imaging and single-cell genomics approaches have revealed that some LAD-NL interactions are variable from cell to cell, while others are very stable...
January 17, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28107243/robotic-guidance-for-s2-alar-iliac-screws-in-spinal-deformity-correction
#9
S Samuel Bederman, Peter Hahn, Vincent Colin, P Douglas Kiester, Nitin N Bhatia
STUDY DESIGN: A retrospective cohort study of patients who underwent S2-alar-iliac (S2AI) screw insertion using robotic guidance in long constructs for spinal deformity correction extending to the sacrum performed at a single institution. OBJECTIVE: To assess and evaluate the feasibility and accuracy of robotic guidance for S2AI screw insertion. SUMMARY OF BACKGROUND DATA: Pelvic fixation has become a common adjunct to long fusions extending to the sacrum...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106716/tracking-and-classification-of-in-air-hand-gesture-based-on-thermal-guided-joint-filter
#10
Seongwan Kim, Yuseok Ban, Sangyoun Lee
The research on hand gestures has attracted many image processing-related studies, as it intuitively conveys the intention of a human as it pertains to motional meaning. Various sensors have been used to exploit the advantages of different modalities for the extraction of important information conveyed by the hand gesture of a user. Although many works have focused on learning the benefits of thermal information from thermal cameras, most have focused on face recognition or human body detection, rather than hand gesture recognition...
January 17, 2017: Sensors
https://www.readbyqxmd.com/read/28106426/unified-time-and-frequency-picture-of-ultrafast-atomic-excitation-in-strong-laser-fields
#11
H Zimmermann, S Patchkovskii, M Ivanov, U Eichmann
Excitation and ionization in strong laser fields lies at the heart of such diverse research directions as high-harmonic generation and spectroscopy, laser-induced diffraction imaging, emission of femtosecond electron bunches from nanotips, self-guiding, filamentation and mirrorless lasing during propagation of light in atmospheres. While extensive quantum mechanical and semiclassical calculations on strong-field ionization are well backed by sophisticated experiments, the existing scattered theoretical work aiming at a full quantitative understanding of strong-field excitation lacks experimental confirmation...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106206/moo3-x-quantum-dots-for-photoacoustic-imaging-guided-photothermal-photodynamic-cancer-treatment
#12
Dandan Ding, Wei Guo, Chongshen Guo, Jianzhe Sun, Nannan Zheng, Fei Wang, Mei Yan, Shaoqin Liu
A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO3-x quantum dots (QDs). Due to their strong NIR harvesting ability, MoO3-x QDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a "dual-punch" to cancer cells...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28105559/mature-cystic-teratoma-of-the-ovary-a-cutting-edge-overview-on-imaging-features
#13
REVIEW
Hilal Sahin, Samir Abdullazade, Muzaffer Sanci
Mature cystic teratoma (MCT) is the most common neoplasm of the ovary and includes at least two well- differentiated germ cell layers. Different combinations of mature tissue derivatives with varying arrangements in the tumour cause a wide spectrum of radiological presentation ranging from a purely cystic mass to a complex cystic mass with a considerable solid component. In different imaging modalities, each radiological feature reflects a specific pathologic equivalent that forms because of diverse compositions of histological components...
January 19, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28105177/-18-f-fluoroethyl-l-tyrosine-positron-emission-tomography-guided-diagnosis-of-a-malignant-intramedullary-spinal-cord-tumor
#14
Sied Kebir, Okka Kimmich, Pitt Niehusmann, Florian C Gaertner, Markus Essler, Jennifer Landsberg, Thomas Klockgether, Matthias Simon, Ulrich Herrlinger, Martin Glas
Diagnosis in patients with a suspected malignant intramedullary lesion that requires biopsy for definitive diagnosis may be challenging, as spinal cord surgery carries the risk of irreversible neurological deficits. The current study presents the first case of (18)F-fluoroethyl-L-tyrosine ((18)F-FET) positron emission tomography (PET) imaging in a patient with a spinal cord tumor. The patient was unsuitable for magnetic resonance imaging due to his implanted cardiac defibrillator. (18)F-FET PET indicated a high-grade malignancy of the spinal cord, justifying tumor biopsy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105165/the-value-of-64-slice-spiral-ct-perfusion-imaging-in-the-treatment-of-liver-cancer-with-argon-helium-cryoablation
#15
Yinggang Lv, Yurong Jin, Qiaohuan Yan, Dingling Yuan, Yanling Wang, Xianping Li, Yanfeng Shen
We analyzed the effectiveness of using 64-slice spiral computed tomography (CT) and perfusion imaging to guide argon-helium cryoablation treatment of liver cancer. In total, 60 cases of advanced hepatocellular carcinoma before surgery treated with argon-helium cryoablation were inlcuded in the present study. Retrospective summary of the 60 cases of metaphase and advanced liver cancer were used as the control group. The control group were treated using cryoablation with argon-helium knife. We used enhanced scanning with 64-slice spiral CT to define the extent of their lesions and prepared a plan of percutaneous cryoablation for the treatment...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104744/spect-ct-imaging-of-the-novel-her2-targeted-peptide-probe-99mtc-hynic-h6f-in-breast-cancer-mouse-models
#16
Liqiang Li, Yue Wu, Zihua Wang, Bing Jia, Zhiyuan Hu, Chengyan Dong, Fan Wang
OBJECTIVES: Overexpression of human epidermal growth factor receptor 2 (HER2) plays important roles in tumorigenesis and tumor progression in breast cancer. Nuclear imaging of HER2 expression in tumors might detect all HER2-positive tumors throughout the body and guide HER2-targeted therapies for patients. We therefore aimed to develop a HER2-targeted peptide probe for breast cancer imaging. A novel single-photon emission computed tomography (SPECT) imaging probe, (99m)Tc-HYNIC-H6F, was prepared and then evaluated in breast cancer animal models...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28104531/diagnosis-and-treatment-of-gouty-tophi-in-the-patellar-tendon-using-ultrasound-guided-needle-barbotage-a-case-report
#17
Ricardo E Colberg, Rachel B Geffen
A 73-year-old male presented with non-traumatic debilitating anterior left knee pain. Magnetic resonance imaging suggested a partial patellar tendon tear. However, ultrasound imaging revealed multiple small hyperechoic areas with posterior acoustic shadowing with intermixed hypoechoic fluid within the proximal patellar tendon, consistent with gouty tophi. The patient underwent ultrasound-guided needle barbotage of the tophi. Gout was confirmed by the presence of uric acid crystals in the aspirate. He had immediate pain relief...
January 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28104299/liquid-fiducial-marker-applicability-in-proton-therapy-of-locally-advanced-lung-cancer
#18
Jonas Scherman Rydhög, Rosalind Perrin, Rasmus Irming Jølck, Francis Gagnon-Moisan, Klaus Richter Larsen, Paul Clementsen, Steen Riisgaard de Blanck, Gitte Fredberg Persson, Damien Charles Weber, Tony Lomax, Thomas Lars Andresen, Per Munck Af Rosenschold
BACKGROUND AND PURPOSE: We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). MATERIALS AND METHODS: The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. PBSPT treatment planning on computer tomography scans of five patients with LALC with the LFM implanted was performed with 1-3 fields...
January 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28103971/-surgical-treatment-of-small-pulmonary-nodules-under-video-assisted-thoracoscopy-%C3%A2-a-report-of-129-cases
#19
Tong Wang, Tiansheng Yan, Feng Wan, Shaohua Ma, Keyi Wang, Jingdi Wang, Jintao Song, Wei He, Jie Bai, Liang Jin
BACKGROUND: The development of image technology has led to increasing detection of pulmonary small nodules year by year, but the determination of their nature before operation is difficult. This clinical study aimed to investigate the necessity and feasibility of surgical resection of pulmonary small nodules through a minimally invasive approach and the operational manner of non-small cell lung cancer (NSCLC). METHODS: The clinical data of 129 cases with pulmonary small nodule of 10 mm or less in diameter were retrospectively analyzed in our hospital from December 2013 to November 2016...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103621/development-and-validation-of-a-training-module-on-the-use-of-acetic-acid-for-the-detection-of-barrett-s-neoplasia
#20
Fergus J Q Chedgy, Kesavan Kandiah, Hugh Barr, Simon Dwerryhouse, Balint Eross, Charles Gordon, Susi Green, Andy Li, James Brown, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Acetic acid chromoendoscopy (AAC) enhances the ability to correctly identify Barrett's neoplasia, and is increasingly used by both expert and nonexpert endoscopists. Despite its increasing use, there is no validated training strategy to achieve competence. The aims of our study were to develop a validated training tool in AAC-assisted lesion recognition, to assess endoscopists' baseline knowledge of AAC-assisted lesion recognition, and to evaluate the efficacy and impact of this training tool...
January 19, 2017: Endoscopy
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