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https://www.readbyqxmd.com/read/29677346/reduced-functional-and-anatomic-interhemispheric-homotopic-connectivity-in-primary-open-angle-glaucoma-a-combined-resting-state-fmri-and-dti-study
#1
Qian Wang, Weiwei Chen, Huaizhou Wang, Xun Zhang, Xiaoxia Qu, Ying Wang, Ting Li, Ningli Wang, Junfang Xian
Purpose: To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677321/probing-the-temporal-dynamics-of-the-exploration-exploitation-dilemma-of-eye-movements
#2
Benedikt V Ehinger, Lilli Kaufhold, Peter König
When scanning a visual scene, we are in a constant decision process regarding whether to further exploit the information content at the current fixation or to go on and explore the scene. The balance of these two processes determines the distribution of fixation durations. Using a gaze-contingent paradigm, we experimentally interrupt this process to probe its state. Here, we developed a guided-viewing task where only a single 3° aperture of an image ("bubble") is displayed. Subjects had to fixate the bubble for an experimentally controlled time (forced fixation time)...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677217/optimisation-of-three-dimensional-lower-jaw-resection-margin-planning-using-a-novel-black-bone-magnetic-resonance-imaging-protocol
#3
Astrid M Hoving, Joep Kraeima, Rutger H Schepers, Hildebrand Dijkstra, Jan Hendrik Potze, Bart Dorgelo, Max J H Witjes
BACKGROUND: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. The tumour margins are difficult to visualise on CT, whereas they are clearly visible on MRI scans. The aim of this study was to change the conventional CT-based workflow by developing a method for 3D MRI-based lower jaw models...
2018: PloS One
https://www.readbyqxmd.com/read/29676909/-18-f-positron-emitting-trimethine-cyanine-fluorescent-contrast-for-image-guided-prostate-cancer-management
#4
Harikrishna Kommidi, Hua Guo, Fuad Nurili, Yogindra Vedvyas, Moonsoo M Jin, Timothy D McClure, Behfar Ehdaie, Haluk B Sayman, Oguz Akin, Omer Aras, Richard Ting
[18/19 F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19 F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19 F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18 F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells...
April 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29676908/fluorine-grafted-cu7s4-au-heterodimers-for-multimodal-imaging-guided-photothermal-therapy-with-high-penetration-depth
#5
Jiabin Cui, Rui Jiang, Chang Guo, Xilin Bai, Suying Xu, Leyu Wang
We report the multifunctional nanocomposites (NCs) consisting of 19F-moieties grafted Cu7S4-Au nanoparticles (NPs) through click chemistry for sensitive and negligible background 19F-magnetic resonance imaging (19F-MRI) and computed tomography (CT) imaging guided photothermal therapy. The localized surface plasmon resonance (LSPR) peak can be reasonably tuned to the in vivo transparent window (800-900 nm) by coupling Au NPs (<10 nm, LSPR 530 nm) with Cu7S4 NPs (<15 nm, LSPR 1500 nm) into the Cu7S4-Au heterodimers...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29676568/toward-rechargeable-persistent-luminescence-for-the-first-and-third-biological-windows-via-persistent-energy-transfer-and-electron-trap-redistribution
#6
Jian Xu, Daisuke Murata, Jumpei Ueda, Bruno Viana, Setsuhisa Tanabe
Persistent luminescence (PersL) imaging without real-time external excitation has been regarded as the next generation of autofluorescence-free optical imaging technology. However, to achieve improved imaging resolution and deep tissue penetration, developing new near-infrared (NIR) persistent phosphors with intense and long duration PersL over 1000 nm is still a challenging but urgent task in this field. Herein, making use of the persistent energy transfer process from Cr3+ to Er3+ , we report a novel garnet persistent phosphor of Y3 Al2 Ga3 O12 codoped with Er3+ and Cr3+ (YAG G:Er-Cr), which shows intense Cr3+ PersL (∼690 nm) in the deep red region matching well with the first biological window (NIR-I, 650-950 nm) and Er3+ PersL (∼1532 nm) in the NIR region matching well with the third biological window (NIR-III, 1500-1800 nm)...
April 20, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29676558/utilizing-intramolecular-photoinduced-electron-transfer-to-enhance-photothermal-tumor-treatment-of-aza-bodipy-based-nir-nanoparticles
#7
Yunjian Xu, Teng Feng, Tianshe Yang, Huanjie Wei, Huiran Yang, Guo Li, Menglong Zhao, Shujuan Liu, Wei Huang, Qiang Zhao
Photothermal therapy (PTT) as a kind of noninvasive tumor treatment has attracted increasing research interest. However, the efficiency of existing PTT agents in the near-infrared (NIR) region is the major problem that has hindered further development of PTT. Herein, we present an effective strategy to construct the efficient photothermal agent by utilizing an intramolecular photoinduced electron transfer (PeT) mechanism, which is able to dramatically improve photothermal conversion efficiency in NIR region...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676166/the-need-for-and-implementation-of-image-guidance-in-radiation-therapy
#8
G S Ibbott
The introduction of image guidance in radiation therapy and its subsequent innovations have revolutionised the delivery of cancer treatment. Modern imaging systems can supplement and often replace the historical practice of relying on external landmarks and laser alignment systems. Rather than depending on markings on the patient's skin, image-guided radiation therapy (IGRT), using techniques such as computed tomography (CT), cone beam CT, MV on-board imaging (OBI), and kV OBI, allows the patient to be positioned based on the internal anatomy...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29675966/unilateral-cervical-plexus-block-for-prosthetic-laryngoplasty-in-the-standing-horse
#9
L Campoy, T Morris, N Ducharme, R Gleed, M Martin-Flores
BACKGROUND: Locoregional anaesthetic techniques can facilitate certain surgeries being performed under standing procedural sedation. The second and third spinal cervical nerves (C2, C3) are part of the cervical plexus and provide sensory innervation to the peri-laryngeal structures in people; block of these nerves might permit laryngeal lateralisation surgery in horses. OBJECTIVES: To describe the anatomical basis for an ultrasound-guided cervical plexus block in horses...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29675357/radiological-signs-associated-with-pulmonary-multi-drug-resistant-tuberculosis-an-analysis-of-published-evidences
#10
Yì Xiáng J Wáng, Myung Jin Chung, Aliaksandr Skrahin, Alex Rosenthal, Andrei Gabrielian, Michael Tartakovsky
Background: Despite that confirmative diagnosis of pulmonary drug-sensitive tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) is determined by microbiological testing, early suspicions of MDR-TB by chest imaging are highly desirable in order to guide diagnostic process. We aim to perform an analysis of currently available literatures on radiological signs associated with pulmonary MDR-TB. Methods: A literature search was performed using PubMed on January 29, 2018...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29675308/quantifying-optical-properties-with-visible-and-near-infrared-optical-coherence-tomography-to-visualize-esophageal-microwave-ablation-zones
#11
Ryan C Niemeier, Sevde Etoz, Daniel A Gil, Melissa C Skala, Christopher L Brace, Jeremy D Rogers
Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible and near-infrared OCT image analysis demonstrated increased scattering coefficients ( μs ) in ablated versus normal tissues (Vis: 347...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675292/linear-array-based-real-time-photoacoustic-imaging-system-with-a-compact-coaxial-excitation-handheld-probe-for-noninvasive-sentinel-lymph-node-mapping
#12
Mucong Li, Chengbo Liu, Xiaojing Gong, Rongqin Zheng, Yuanyuan Bai, Muyue Xing, Xuemin Du, Xiaoyang Liu, Jing Zeng, Riqiang Lin, Huichao Zhou, Shouju Wang, Guangming Lu, Wen Zhu, Chihua Fang, Liang Song
We developed a linear ultrasound array-based real-time photoacoustic imaging system with a compact coaxial excitation handheld photoacoustic imaging probe for guiding sentinel lymph node (SLN) needle biopsy. Compared with previous studies, our system and probe have the following advantages: (1) the imaging probe is quite compact and user-friendly; (2) laser illumination and ultrasonic detection are achieved coaxially, enabling high signal-to-noise ratio; and (3) GPU-based image reconstruction enables real-time imaging and displaying at a frame rate of 20 Hz...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675250/novel-dual-function-near-infrared-ii-fluorescence-and-pet-probe-for-tumor-delineation-and-image-guided-surgery
#13
Yao Sun, Xiaodong Zeng, Yuling Xiao, Changhao Liu, Hua Zhu, Hui Zhou, Ziyang Chen, Fuchun Xu, Jule Wang, Mengyue Zhu, Junzhu Wu, Mei Tian, Hong Zhang, Zixin Deng, Zhen Cheng, Xuechuan Hong
Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674592/synaptic-transmission-from-subplate-neurons-controls-radial-migration-of-neocortical-neurons
#14
Chiaki Ohtaka-Maruyama, Mayumi Okamoto, Kentaro Endo, Minori Oshima, Noe Kaneko, Kei Yura, Haruo Okado, Takaki Miyata, Nobuaki Maeda
The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar neurons is required. Here, we report that subplate neurons, one of the first neuron types born in the neocortex, manage the multipolar-to-bipolar transition of migrating neurons. By histochemical, imaging, and microarray analyses on the mouse embryonic cortex, we found that subplate neurons extend neurites toward the ventricular side of the subplate and form transient glutamatergic synapses on the multipolar neurons just below the subplate...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29674013/the-tipping-point-key-oncologic-imaging-findings-resulting-in-critical-changes-in-the-management-of-malignant-tumors-of-the-gastrointestinal-tract
#15
REVIEW
Jonathan Wu, Lipika Goyal, Ryan Nipp, Jennifer Wo, Motaz Qadan, Raul N Uppot
OBJECTIVE: The purpose of this article is to review tumor staging systems for gastrointestinal tumors including pancreatic adenocarcinoma, hepatocellular carcinoma, cholangiocarcinoma, gastric adenocarcinoma, small bowel adenocarcinoma, rectal carcinoma, and anal carcinoma and identify the key imaging findings ("tipping points"), which change patient management based on changes in tumor staging. CONCLUSION: For all malignant gastrointestinal tumors, there are key imaging findings ("tipping points") including tumor size, tumor extension, lymphadenopathy, vascular invasion, and distant metastasis that dictate patient management and prognosis, based on changes in tumor stage...
January 31, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29674012/interventional-radiology-operated-endoscopy-as-an-adjunct-to-image-guided-interventions
#16
REVIEW
Rajiv N Srinivasa, Jeffrey Forris Beecham Chick, Kyle Cooper, Ravi N Srinivasa
PURPOSE: Interventional radiology-operated endoscopy is an underused technique, which may have a significant impact on the ability to treat patients with a variety of conditions. The purpose of this article is to discuss the setup, equipment, and potential clinical uses of interventional radiology-operated endoscopy. METHODS: A number of new and innovative interventions may be performed in the biliary, genitourinary, and gastrointestinal systems through percutaneous access that interventional radiologists already create...
March 20, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29673821/diagnostic-accuracy-of-a-confocal-laser-endomicroscope-for-in-vivo-differentiation-between-normal-and-tumor-tissue-during-fluorescein-guided-glioma-resection-laboratory-investigation
#17
Evgenii Belykh, Eric J Miller, Arpan A Patel, Mohammedhassan Izady Yazdanabadi, Nikolay L Martirosyan, Kaan Yağmurlu, Baran Bozkurt, Vadim A Byvaltsev, Jennifer M Eschbacher, Peter Nakaji, Mark C Preul
OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from non-tumor areas with a compromised blood-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor brain tissue in an animal glioma model. METHODS: GL261-Luc2 gliomas in C57BL/6 mice were used as a brain tumor model...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29672792/-image-guided-treatment-is-the-future
#18
(no author information available yet)
No abstract text is available yet for this article.
May 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29672613/intravascular-ultrasound-assisted-sizing-in-thoracic-endovascular-aortic-repair-improves-aortic-remodeling-in-type-b-aortic-dissection
#19
Julia Lortz, Konstantinos Tsagakis, Christos Rammos, Michael Horacek, Thomas Schlosser, Heinz Jakob, Tienush Rassaf, Rolf Alexander Jánosi
The precise sizing of the stent graft in thoracic endovascular aortic repair (TEVAR) affects aortic remodeling and hence, further outcome. Covering the proximal entry tear is essential for successful treatment of Type B aortic dissection. Intravascular ultrasound (IVUS) enables real-time aortic diameter assessment, and is especially useful when computed tomography (CT) image quality is poor. IVUS, however, is not routinely utilized due to cost inefficiency. We investigated the impact of IVUS-assisted stent graft sizing on aortic remodeling in TEVAR...
2018: PloS One
https://www.readbyqxmd.com/read/29672421/human-versus-robot-a-propensity-matched-analysis-of-the-accuracy-of-free-hand-versus-robotic-guidance-for-placement-of-s2-alar-iliac-s2ai-screws
#20
Jamal N Shillingford, Joseph L Laratta, Paul J Park, Joseph M Lombardi, Alexander Tuchman, Comron S Saifi, Ronald A Lehman, Lawrence G Lenke
STUDY DESIGN: Retrospective matched cohort analysis. OBJECTIVE: To compare the accuracy of S2 alar-iliac (S2AI) screw placement by robotic guidance versus free hand technique. SUMMARY OF BACKGROUND DATA: Spinopelvic fixation utilizing S2AI screws provides optimal fixation across the lumbosacral junction allowing for solid fusion, especially in long segment fusion constructs. Traditionally, S2AI screw placement has required fluoroscopic guidance for accurate screw placement...
April 18, 2018: Spine
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