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post hemorrhagic hydrocephalus

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https://www.readbyqxmd.com/read/29348677/the-proliferation-capacity-of-cultured-neural-stem-cells-promoted-by-csf-collected-from-sah-patients-correlates-to-clinical-outcome
#1
Yun-An Chen, Kuo-Chuan Wang, Der-Zen Liu, Tai-Horng Young, Li-Kai Tsai
Neurogenesis from endogenous neural stem cells (NSCs) might contribute to functional recovery after stroke based on animal studies; however, the relationship between neurogenesis and post-stroke outcome has rarely been demonstrated in humans. We prospectively collected cerebrospinal fluid (CSF) from 36 patients with subarachnoid hemorrhage (SAH). The CSF was added to the culture medium of the rat NSCs to test the effects on proliferation (proliferation index [PI], percentage of Ki-67 immunoreactive cells). We correlated the PI with functional outcome based on the modified Rankin Scale at 3 months post-SAH...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29249076/endoscopic-third-ventriculostomy-in-children-with-a-fiber-optic-neuroendoscopy
#2
Wenjun Shen, Hasan R Syed, Gurpreet Gandhoke, Roxanna Garcia, Tatiana Pundy, Tadanori Tomita
OBJECTIVE: Endoscopic third ventriculostomy (ETV) provides a shunt-free treatment for obstructive hydrocephalus children. With rapidly evolving technology, the semi-rigid fiber optic neuroendoscopy shows a potential application in ETV by blunt fenestration. A retrospective analysis of our experience is reviewed. METHODS: The authors review infants and children who underwent ETV using this technique from June 2004 to June 2016 with radiological and clinical follow-up done by a single surgeon...
December 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29228970/chemokine-and-cytokine-levels-in-the-lumbar-cerebrospinal-fluid-of-preterm-infants-with-post-hemorrhagic-hydrocephalus
#3
Gakwaya Habiyaremye, Diego M Morales, Clinton D Morgan, James P McAllister, Travis S CreveCoeur, Rowland H Han, Mohamed Gabir, Brandon Baksh, Deanna Mercer, David D Limbrick
BACKGROUND: Neuroinflammation has been implicated in the pathophysiology of post-hemorrhagic hydrocephalus (PHH) of prematurity, but no comprehensive analysis of signaling molecules has been performed using human cerebrospinal fluid (CSF). METHODS: Lumbar CSF levels of key cytokines (IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β1, IFN-γ) and chemokines (XCL-1, CCL-2, CCL-3, CCL-19, CXCL-10, CXCL-11, CXCL-12) were measured using conventional and multiplexed Enzyme-linked Immunosorbent Assays and compared between preterm infants with PHH and those with no known neurological injury...
December 12, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29194369/elevated-systemic-il-6-levels-in-patients-with-aneurysmal-subarachnoid-hemorrhage-is-an-unspecific-marker-for-post-sah-complications
#4
Shafqat Rasul Chaudhry, Birgit Stoffel-Wagner, Thomas Mehari Kinfe, Erdem Güresir, Hartmut Vatter, Dirk Dietrich, Alf Lamprecht, Sajjad Muhammad
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is still a fatal and morbid disease, although bleeding aneurysms can be secured in almost all cases. Occurrence of post-SAH complications including cerebral vasospasm, delayed cerebral ischemia, hydrocephalus, epilepsy, and infections are the main determinants of clinical outcome. Hence, it is important to search for early predictors for specific post-SAH complications to treat these complications properly. Both cellular and molecular (cytokines) inflammation play a key role after aSAH during the phase of occurrence of post-SAH complications...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29175575/brain-granuloma-rare-complication-of-a-retained-catheter-case-report
#5
Andrea Iaquinandi, Francesco Corrivetti, Pierpaolo Lunardi, Amedeo Ferlosio, Elena Giannini, Federica Novegno
BACKGROUND: Ventriculo-peritoneal (VP) shunt is the most frequent treatment for hydrocephalus. Its malfunctioning represents one of the most common problem in neurosurgical practice, often requiring shunt revision procedures. In some cases, the complete removal of a VP shunt may present difficulties, leading the surgeon to leave the ventricular catheter in situ. This decision is often taken in order to avoid possible adverse events, first of all, life-threatening hemorrhagic risks. However, a non-functioning catheter left in the ventricular system represents a prosthetic device which may lead to further complications...
November 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29169929/compound-heterozygous-ryr1-mutations-in-a-preterm-with-arthrogryposis-multiplex-congenita-and-prenatal-cns-bleeding
#6
Florian Brackmann, Matthias Türk, Nils Gratzki, Oliver Rompel, Heinz Jungbluth, Rolf Schröder, Regina Trollmann
RYR1 mutations, the most common cause of non-dystrophic neuromuscular disorders, are associated with the malignant hyperthermia susceptibility (MHS) trait as well as congenital myopathies with widely variable clinical and histopathological manifestations. Recently, bleeding anomalies have been reported in association with certain RYR1 mutations. Here we report a preterm infant born at 32 weeks gestation with arthrogryposis multiplex congenita due to compound heterozygous, previously MHS-associated RYR1 mutations, with additional signs of prenatal hemorrhage...
September 28, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29059837/cranial-ultrasound-based-prediction-of-post-hemorrhagic-hydrocephalus-outcome-in-premature-neonates-with-intraventricular-hemorrhage
#7
Pooneh R Tabrizi, Rawad Obeid, Awais Mansoor, Scott Ensel, Juan J Cerrolaza, Anna Penn, Marius George Linguraru
Premature neonates with intraventricular hemorrhage (IVH) followed by post hemorrhagic hydrocephalus (PHH) are at high risk for brain injury. Cranial ultrasound (CUS) is used for monitoring of premature neonates during the first weeks after birth to identify IVH and follow the progression to PHH. However, the lack of a standardized method for CUS evaluation has led to significant variability in decision making regarding treatment. We propose a quantitative imaging tool for the evaluation of PHH on CUS for premature neonates based on morphological features of the cerebral ventricles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042922/endoscopy-in-the-treatment-of-slit-ventricle-syndrome
#8
Jiaping Zheng, Guoqiang Chen, Qing Xiao, Yiyang Huang, Yupeng Guo
The present study aimed to investigate the efficacy of endoscopy in the treatment of post-shunt placement for slit ventricle syndrome (SVS). Endoscopic surgery was performed on 18 patients with SVS between October 2004 and December 2012. Sex, age, causes of the hydrocephalus, ventricular size and imaging data were collected and analyzed. All patients were divided into two groups according to ventricular size and underwent endoscopic surgeries, including endoscopic third ventriculostomy (ETV), endoscopic aqueductoplasty and cystocisternostomy...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29031644/a-preliminary-evaluation-of-glial-cell-line-derived-neurotrophic-factor-gdnf-levels-in-cerebrospinal-fluid-across-various-gestational-ages-and-clinical-conditions-of-the-neonate
#9
Rahul Rajkumar, Bhavana Bhaya, Divya Mamilla, Theresa Czech, Esther Kisseih, Arun Saini, Nitin Chouthai
BACKGROUND: This study aims to investigate glial cell derived neurotrophic factor (GDNF) levels in newborns' umbilical cord blood and cerebrospinal fluid across various perinatal growth parameters and clinical conditions. METHODS: Cord blood from 20 newborns and 58 residual CSF samples (stored after completion of clinical testing) were collected. GDNF levels were determined using GDNF ELISA kits from R&D Systems in triplicates with appropriate controls to eliminate background...
October 12, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28987840/endovascular-treatment-of-ruptured-vertebrobasilar-dissecting-aneurysms-using-flow-diversion-embolization-devices-single-institution-experience
#10
Waldo R Guerrero, Santiago Ortega-Gutierrez, Minako Hayakawa, Colin P Derdeyn, James D Rossen, David Hasan, Edgar A Samaniego
OBJECTIVE: Treatment of ruptured posterior circulation dissecting aneurysms is technically challenging with potentially high morbidity and mortality. We sought to assess the safety and feasibility of using a flow diversion devices (FDD) and a specific acute antiplatelet aggregation protocol in the management of ruptured dissecting aneurysms. METHODS: Subjects with ruptured dissecting aneurysms treated during a three-year period were retrospectively identified from a prospective registry...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28973194/shunt-dependent-hydrocephalus-after-aneurysmal-subarachnoid-hemorrhage-predictors-and-long-term-functional-outcomes
#11
Gabriella M Paisan, Dale Ding, Robert M Starke, R Webster Crowley, Kenneth C Liu
BACKGROUND: Although chronic hydrocephalus requiring shunt placement is a known sequela of aneurysmal subarachnoid hemorrhage (aSAH), its effect on long-term functional outcomes is incompletely understood. OBJECTIVE: To identify predictors of shunt-dependent hydrocephalus and shunt complications after aSAH and determine the effect of shunt dependence on functional outcomes in aSAH patients. METHODS: We evaluated a database of patients treated for aSAH at a single center from 2000 to 2015...
July 31, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28964945/validation-of-a-predictive-scoring-system-for-ventriculoperitoneal-shunt-insertion-after-aneurysmal-subarachnoid-hemorrhage
#12
Raghav Gupta, Luis C Ascanio, Alejandro Enriquez-Marulanda, Christoph J Griessenauer, Anu Chinnadurai, Ray Jhun, Abdulrahman Alturki, Christopher S Ogilvy, Ajith J Thomas, Justin M Moore
BACKGROUND: Hydrocephalus is a frequently encountered complication in the context of aneurysmal subarachnoid hemorrhage (aSAH). Here, we performed an external validation of the recently proposed postsubarachnoid shunt scoring (PS3) system, which aims to stratify patients presenting with aSAH based on their relative risk of requiring ventriculoperitoneal (VP) shunt insertion. METHODS: A retrospective review of all patients presenting with aSAH to our institution between July 2007 and December 2016, who underwent computed tomography imaging at the time of hospital admission, was performed...
September 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28956308/bedside-transcranial-sonography-monitoring-in-a-patient-with-hydrocephalus-post-subarachnoid-hemorrhage
#13
Ahmed Najjar, André Y Denault, Michel W Bojanowski
BACKGROUND: Development of hydrocephalus can occur after subarachnoid hemorrhage (SAH). Typically, it is diagnosed with computed tomography, CT, scan. However, transcranial sonography (TCS) can be used particularly in patients with craniotomy which removes the acoustic interference of the skull and allows a closer up visualization of brain structures through the skin. CASE PRESENTATION: We report a 73-year-old woman who was hospitalized for SAH and developed acute hydrocephalus requiring an external ventricular drain (EVD)...
September 27, 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28941226/respiratory-outcomes-after-initial-hospital-discharge-in-children-with-ventricular-shunts-and-bronchopulmonary-dysplasia
#14
Sharon A McGrath-Morrow, Edward S Ahn, Joseph M Collaco
INTRODUCTION: Children born premature who require ventricular shunt placement for post hemorrhagic hydrocephalus are at increased risk for neurodevelopmental delay. We hypothesized that preterm infants with bronchopulmonary dysplasia (BPD) who require ventricular shunt (VS) placement are at additive risk for long-term respiratory morbidities due to their higher likelihood of neurodevelopmental delay. We also hypothesized that children with BPD and ventricular shunts would require frequent shunt revisions during early childhood following initial shunt placement...
October 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28881122/traumatic-brain-injury-in-children-under-age-24-months-analysis-of-demographic-data-risk-factors-and-outcomes-of-post-traumatic-seizure
#15
Sang-Youl Yoon, Yeon-Ju Choi, Seong-Hyun Park, Jeong-Hyun Hwang, Sung Kyoo Hwang
OBJECTIVE: Traumatic brain injury (TBI) in children under age 24 months has characteristic features because the brain at this age is rapidly growing and sutures are opened. Moreover, children this age are completely dependent on their parents. We analyzed the demographic data and risk factors for outcomes in TBI patients in this age group to elucidate their clinical characteristics. METHODS: We retrospectively reviewed the medical records and radiological films of children under 24 months who were admitted to Kyungpook National University Hospital from January 2004 to December 2013 for TBI...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28831694/increased-plasma-galectin-3-preceding-the-development-of-delayed-cerebral-infarction-and-eventual-poor-outcome-in-non-severe-aneurysmal-subarachnoid-hemorrhage
#16
Hirofumi Nishikawa, Yoshinari Nakatsuka, Masato Shiba, Fumihiro Kawakita, Masashi Fujimoto, Hidenori Suzuki
A matricellular protein galectin-3 is involved in tissue injury and inflammation, but the role of galectin-3 remains unclear in aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study was to assess whether acute-stage galectin-3 levels were associated with the subsequent development of neurovascular events and outcome after SAH. This study included 83 consecutive patients diagnosed with aneurysmal SAH of resuscitated World Federation of Neurological Surgeons (WFNS) grades 1-3. Plasma galectin-3 levels were once measured on days 1-3 (the day after clipping or coiling)...
August 22, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28744710/outcome-of-extreme-preterm-babies-treated-with-ventriculo-peritoneal-shunt-for-post-hemorrhagic-hydrocephalus
#17
REVIEW
B Vishnu Bhat, Nivedita Mondal
No abstract text is available yet for this article.
September 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28652120/predictors-of-shunt-dependent-hydrocephalus-after-aneurysmal-subarachnoid-hemorrhage-a-systematic-review-and-meta-analysis
#18
Zhiyi Xie, Xin Hu, Xin Zan, Sen Lin, Hao Li, Chao You
BACKGROUND: Hydrocephalus is a well-recognized complication after aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to identify predictors for shunt-dependent hydrocephalus (SDHC) after aSAH via a systematic review and meta-analysis. METHODS: A systematic search was conducted using the Embase, MEDLINE, and Web of Science databases for studies pertaining to aSAH and SDHC. Risk factors were assessed by meta-analysis when they were reported by at least 2 studies...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28609751/aneurysmal-subarachnoid-hemorrhage-lead-to-systemic-upregulation-of-il-23-il-17-inflammatory-axis
#19
Shafqat Rasul Chaudhry, Erdem Güresir, Hartmut Vatter, Thomas M Kinfe, Dirk Dietrich, Alf Lamprecht, Sajjad Muhammad
IL-23 and IL-17 are pro-inflammatory cytokines. IL-23 is secreted by activated macrophages and dendritic cells, while IL-17 by Th17 cells. Serum IL-23 and IL-17 are known to be elevated in numerous inflammatory diseases including neurodegenerative diseases. The role of serum IL-23 and IL-17 in aneurysmal subarachnoid hemorrhage (aSAH) has still not been investigated. The present work investigates the serum IL-23 and IL-17 levels and their association with post hemorrhagic complications and clinical outcome in patients with aSAH...
June 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28559078/risk-factors-for-ventriculoperitoneal-shunt-dependency-in-patients-with-spontaneous-cerebellar-hemorrhage
#20
Shih-Yuan Hsu, Hsin-Huan Chang, Fu-Yuan Shih, Yu-Jun Lin, Wei-Che Lin, Ben-Chung Cheng, Yu-Jih Su, Chia-Te Kung, Yu-Ni Ho, Nai-Wen Tsai, Cheng-Hsien Lu, Hung-Chen Wang
BACKGROUND: Hydrocephalus is a common complication after spontaneous cerebellar hemorrhage (CH). This study focused on predicting ventriculoperitorneal (VP) shunt dependency in patients with spontaneous CH. METHODS: Ninety-nine patients with spontaneous CH were evaluated in this retrospective study. A comparison between patients with and those without VP shunt dependency during hospitalization was made. RESULTS: VP shunt-dependent hydrocephalus developed in 19...
September 2017: World Neurosurgery
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