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Fibroadenoma

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https://www.readbyqxmd.com/read/28807345/ampk-expression-patterns-are-significantly-associated-with-poor-prognosis-in-breast-cancer-patients
#1
Jaudah Al-Maghrabi, Kaltoom Al-Sakkaf, Imtiaz Ahmad Qureshi, Nadeem Shafique Butt, Lila Damnhory, Mohamed Elshal, Basim Al-Maghrabi, Alia Aldahlawi, Sawsan Ashoor, Barry Brown, Pauline Dobson, Mohamad Nidal Khabaz
Many investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models. The goal of this research is to assess the association of the immunohistochemical expression of AMPK in human mammary tumours with the clinical data of breast cancer patients. 449 cases of previously diagnosed breast cancer, and 27 tissue samples of fibroadenomas and normal breast were utilized for detection of AMPK expression using tissue microarrays and immunohistochemistry...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28791998/-fibroepithelial-tumors-of-the-anogenital-mammary-like-glands
#2
A M Konstantinova, K V Shelekhova
Mammary-like glands are a normal anatomical component of the anogenital region. The tumors occurring in them morphologically mimic the similar diseases of the breast. The paper presents a case of vulvar fibroadenoma with leaf-like outgrowths and apocrine metaplasia in a 38-year-old female patient. It describes the clinical and morphological characteristics of fibroadenomas and benign phyllodes tumors in the anogenital region.
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28777747/breast-fibroadenoma-with-pseudoangiomatous-pash-like-stroma
#3
Josko Bezic, Jelena Srbljin
Pseudoangiomatous stromal hyperplasia (PASH) is a breast stromal change, histologically characterized by anastomosing, slit-like spaces lined by slender myofibroblasts and surrounded by dense collagenous stroma. Mass forming cases clinically and radiologically simulate fibroadenoma. A middle aged women presented with unpalpable breast nodule discovered on ultrasound examination. The ultrasound characteristics were typical for fibroadenoma, while fine-needle aspiration cytology was inconclusive. The histological examination of the lumpectomy specimen showed fibroadenoma with peculiar stromal alteration consistent with pseudoangiomatous stromal hyperplasia...
August 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28764179/bilateral-giant-juvenile-fibroadenoma-of-breast
#4
Nikhil Makkar, Sumitoj Singh, Surinder Paul, Mandeep Singh Sandhu, Ashok Kumar
Fibroadenomas are benign lesions of breast commonly found in young age group. These focal tumours contain both mesenchymal and glandular tissue. Giant juvenile fibroma of breast is rare variant of fibroadenoma found usually in less than 20 years of age. They present with rapid enlargement of single or multiple, discrete, painless large nodule of breast. A 14-years-old premenarche girl presented with large bilateral breast lumps for two months. FNAC showed features of juvenile fibroadenoma. Breast conserving surgical excision of lumps was performed and histopathology confirmed the diagnosis of juvenile fibroadenoma...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28751520/validation-of-the-singapore-nomogram-for-outcome-prediction-in-breast-phyllodes-tumours-in-a-large-patient-cohort
#5
Tze Wei Chng, Mihir Gudi, Swee Ho Lim, HuiHua Li, Puay Hoon Tan
AIMS: To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of fibroadenomas and phyllodes tumours within a subset of our cohort. METHODS: Histological parameters, surgical margin status and clinical follow-up data of 259 women diagnosed with phyllodes tumours were analysed. Patients with concurrent malignant or premalignant disease were excluded from the validation to minimise confounding influences...
July 27, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28744086/differentiation-of-secondary-involvement-of-the-breast-by-lymphoreticular-malignancy-from-fibroadenoma-using-ultrasound-elastography-a-report-of-two-cases
#6
Eren Abdulkadir, Ertan Gulhan, Sila Ulus
Extramedullary lymphoma infiltration of the breast by lymphoblastic lymphoma is very rare and most cases are of B-cell lineage; T-cell neoplasms represent less than 10% of all breast lymphomas. Here, we report one patient with lymphoblastic lymphoma and one patient with leukemia, who have similar lesions in breasts with different ultrasound elastography findings. Ultrasound-guided tru-cut biopsies were performed and the first lesion was confirmed as lymphoma infiltration and the second as fibroadenoma. In cases of breast mass presence in patients with a history of hematologic malignancies such as lymphoma or leukemia, breast infiltration should be kept in mind...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28738381/cytological-criteria-to-distinguish-phyllodes-tumour-of-the-breast-from-fibroadenoma
#7
Robert M Maritz, Pamela M Michelow
OBJECTIVE: To determine whether there are significant differences between fibroadenomas and phyllodes tumours with regard to selected cytomorphological features. STUDY DESIGN: A 10-year retrospective review was performed of patients who underwent excision of a fibroadenoma or phyllodes tumour and in whom a preoperative fine-needle aspiration was performed. The following cytological criteria were assessed: number of stromal and epithelial fragments, stromal-to-epithelial ratio, stromal cellularity, stromal borders, stromal atypia, and proportion of background wavy spindled cells...
July 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28688536/fibroepithelial-lesions-the-who-spectrum
#8
REVIEW
Gregor Krings, Gregory R Bean, Yunn-Yi Chen
Fibroepithelial lesions of the breast comprise a morphologically and biologically heterogeneous group of biphasic tumors with epithelial and stromal components that demonstrate widely variable clinical behavior. Fibroadenomas are common benign tumors with a number of histologic variants, most of which pose no diagnostic challenge. Cellular and juvenile fibroadenomas can have overlapping features with phyllodes tumors and should be recognized. Phyllodes tumors constitute a spectrum of lesions with varying clinical behavior and are graded as benign, borderline or malignant based on a set of histologic features according to recommendations by the World Health Organization (WHO)...
May 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28687686/isolated-insulin-derived-amyloidoma-of-the-breast
#9
Jonathan Mark Mayhew, Tanya Alan, Venu Kalidindi, Tasha A K Gandamihardja
Isolated amyloidomas derived from insulin are extremely rare, and there is only one reported case to date of insulin-derived amyloidoma in the breast.We present the case of a 36-year-old woman reporting a lump in the right breast. It was clinically assessed as a probable fibroadenoma but was removed surgically given the size of the lesion. On histological analysis, the lesion had features consistent with amyloid. Further investigations showed the amyloid to be derived from insulin. The lump was removed in its entirety, and the patient made a full recovery...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28687161/deregulation-of-mir-126-3p-in-basal-like-breast-cancers-stroma-and-its-clinical-significance
#10
Jing Li, Jin Liang Ping, Bo Ma, Ying Rong Chen, Li Qin Li
INTRODUCTION: The aim of this study was to investigate miR-126-3p expression in stroma and tumor cells of basal-like breast cancer tissues, in an effort to elucidate the potential effect of miR-126-3p on tumor microenvironment and progress of basal-like breast cancer. METHODS: Expression levels of miR-126-3p in 33 paired basal-like breast cancer tissues were assayed by real-time quantitative PCR. Tumor cells and normal epithelial cell were isolated from ten paired basal-like breast cancer tissues and matched adjacent tissues, separately, using laser capture microdissect(LCM)-based PCR method...
August 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28685877/availability-of-immunocytochemistry-using-cocktail-antibody-targeting-p63-cytokeratin14-for-the-differential-diagnosis-of-fibroadenoma-and-ductal-carcinoma-in-situ-in-fine-needle-aspiration-cytology-of-the-breast
#11
I Maeda, Y Oana, K Tsugawa, M Takagi
OBJECTIVE: The differential diagnosis of fibroadenoma (FA) and ductal carcinoma in situ (DCIS) has been problematic in fine needle aspiration biopsy (FNAC) because it has been difficult to differentiate between the "large epithelial clusters" associated with FA and those associated with DCIS. The purpose of this study was to prospectively validate the usefulness of immunocytochemical staining using cocktail antibody targeting p63/CK14 in the differential diagnosis of FA and DCIS. MATERIALS AND METHODS: Twenty patients diagnosed as having an uncertain malignant potential (indeterminate) for breast cancer on the basis of a FNAC finding were selected randomly: ten patients with FA and ten with DCIS...
July 6, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28663913/plum-pudding-random-medium-model-of-biological-tissue-toward-remote-microscopy-from-spectroscopic-light-scattering
#12
Min Xu
Biological tissue has a complex structure and exhibits rich spectroscopic behavior. There has been no tissue model until now that has been able to account for the observed spectroscopy of tissue light scattering and its anisotropy. Here we present, for the first time, a plum pudding random medium (PPRM) model for biological tissue which succinctly describes tissue as a superposition of distinctive scattering structures (plum) embedded inside a fractal continuous medium of background refractive index fluctuation (pudding)...
June 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28658847/massive-benign-phyllodes-tumour-of-breast-complicating-pregnancy
#13
Anji Reddy Kallam, Vandana Kanumury, Rama Murthy Korumilli, Vahini Gudeli, Havya Polavarapu
Phyllodes tumour of the breast, earlier called cystosarcomaphyllodes, is a rare fibroepithelial breast neoplasm that occurs in all age groups from adolescents to elderly. Phyllodes tumour occurring during pregnancy and associated with lactating breast is extremely rare. Giant phyllodes tumours or giant fibroadenomas are those measuring more than 10 cms in diameter and weighing more than 500 gm. Phyllodes tumour typically exhibits an exclusive intracanalicular growth pattern of fibroepithelial cells with classical, deep leaf-like stromal projections into dilated lumens from which its name "phyllodes" is derived...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655120/a-rare-benign-tumor-of-breast-masquerading-on-fine-needle-aspiration-cytology-a%C3%A2-case%C3%A2-report
#14
Banushree Cs, Ramachandra V Bhat, Sri Vengadesh Gopal
Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. We present an extremely rare case of pleomorphic adenoma of breast diagnosed on FNAC with histopathological confirmation.
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655118/giant-juvenile-fibroadenoma-in-a-9-year-old-a-case-presentation-and-review-of-the-current-literature
#15
Michalina Kupsik, Brian Yep, Suela Sulo, Heidi Memmel
Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. They are defined as being larger than 5 cm or weighing more than 500 g. The peak age has been reported between the ages of 17 and 20, with less than 5% of these in patients less than 18-years-old.We present a 9-year-old, pre-menstrual, Nigerian female with no known family history of breast masses or cancers who developed spontaneous giant fibroadenoma measuring approximately 13  cm × 13 cm...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28648934/molecular-alterations-in-lesions-of-anogenital-mammary-like-glands-and-their-mammary-counterparts-including-hidradenoma-papilliferum-intraductal-papilloma-fibroadenoma-and-phyllodes-tumor
#16
Anastasia M Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V Spagnolo, Colin J R Stewart, Francesca Portelli, Michal Michal, Dmitry V Kazakov
Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28646155/breast-cancer-multi-classification-from-histopathological-images-with-structured-deep-learning-model
#17
Zhongyi Han, Benzheng Wei, Yuanjie Zheng, Yilong Yin, Kejian Li, Shuo Li
Automated breast cancer multi-classification from histopathological images plays a key role in computer-aided breast cancer diagnosis or prognosis. Breast cancer multi-classification is to identify subordinate classes of breast cancer (Ductal carcinoma, Fibroadenoma, Lobular carcinoma, etc.). However, breast cancer multi-classification from histopathological images faces two main challenges from: (1) the great difficulties in breast cancer multi-classification methods contrasting with the classification of binary classes (benign and malignant), and (2) the subtle differences in multiple classes due to the broad variability of high-resolution image appearances, high coherency of cancerous cells, and extensive inhomogeneity of color distribution...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631431/phaeohyphomycosis-breast-masquerading-as-fibroadenoma-in-a-young-teenage-girl
#18
Amita Jain Gupta, Meeta Singh, Surekha Yadav, Nita Khurana, Shyam Lata Jain, Rohit Chawla, Sunil Laka, Anurag Mishra
Phaeohyphomycosis is an unusual granulomatous fungal infection, observed in immunocompromised or diabetic patients; however, it is even rarer in immunocompetent patients. Cytological findings of the same have been infrequently reported. The histopathological diagnosis or fungal culture helps in definitive diagnosis to identify the exact fungal species. Hereby, we report a rare case of invasive fungal infection in a breast lump in a young female, presenting as fibroadenoma breast. Fine needle aspiration cytology from the breast lesion showed the presence of septate acute-angled branching fungal hyphae with focal pigmentation, morphologically suggestive of phaeohyphomycosis which was positive with fungal stains...
June 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28623243/metaplastic-breast-carcinoma-with-chondroid-differentiation-a-rare-variant-of-infiltrative-carcinoma-in-a-38-year-old-woman
#19
Shokouh Taghipour Zahir, Mostafa Javannejad
Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28608564/b-acute-lymphoblastic-leukemia-lymphoma-involving-pre-existing-fibroadenoma-of-the-breast
#20
Mayur Kothiya, Tanuja Shet, Shalaka Joshi, Hasmukh Jain, Seema Kembhavi, Sangeeta Desai
No abstract text is available yet for this article.
June 13, 2017: Breast Journal
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