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Fibroadenoma

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https://www.readbyqxmd.com/read/28631431/phaeohyphomycosis-breast-masquerading-as-fibroadenoma-in-a-young-teenage-girl
#1
Amita Jain Gupta, Meeta Singh, Surekha Yadav, Nita Khurana, Shyam Lata Jain, Rohit Chawla, Sunil Laka, Anurag Mishra
Phaeohyphomycosis is an unusual granulomatous fungal infection, observed in immunocompromised or diabetic patients; however, it is even rarer in immunocompetent patients. Cytological findings of the same have been infrequently reported. The histopathological diagnosis or fungal culture helps in definitive diagnosis to identify the exact fungal species. Hereby, we report a rare case of invasive fungal infection in a breast lump in a young female, presenting as fibroadenoma breast. Fine needle aspiration cytology from the breast lesion showed the presence of septate acute-angled branching fungal hyphae with focal pigmentation, morphologically suggestive of phaeohyphomycosis which was positive with fungal stains...
June 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28623243/metaplastic-breast-carcinoma-with-chondroid-differentiation-a-rare-variant-of-infiltrative-carcinoma-in-a-38-year-old-woman
#2
Shokouh Taghipour Zahir, Mostafa Javannejad
Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28608564/b-acute-lymphoblastic-leukemia-lymphoma-involving-pre-existing-fibroadenoma-of-the-breast
#3
Mayur Kothiya, Tanuja Shet, Shalaka Joshi, Hasmukh Jain, Seema Kembhavi, Sangeeta Desai
No abstract text is available yet for this article.
June 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28584621/fibroadenoma-progress-to-ductal-carcinoma-in-situ-infiltrating-ductal-carcinoma-and-lymph-node-metastasis-report-an-unusual-case
#4
Yu-Ting Wu, Hua-Koon Wu, Shou-Tung Chen, Chih-Jung Chen, Dar-Ren Chen, Hung-Wen Lai
Fibroadenoma of the breast is the most common benign neoplasm in young women who present with a palpable, movable mass. Malignancy inside fibroadenomas is rare, with reported rates ranging from 0.002% to 0.125%. Carcinoma in situ inside a fibroadenoma is usually found incidentally when tumours are excised. Whether fibroadenoma is a risk factor for breast cancer remains controversial. Due to the rarity of carcinomas inside fibroadenomas, medical institutes have little experience with this phenomenon. We report an unusual case in which progression occurred from benign fibroadenoma to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis...
May 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28584515/circumareolar-incision-subdermal-tunneling-dissection-for-excision-of-multiple-breast-fibroadenomata
#5
S O Agodirin, G A Rahman, S A Olatoke, H J Akande
Excision of multiple fibroadenomas (MF) in separate breast quadrants presents difficulties of number and location of incision(s) and extent of tissue dissection and may be associated with more complications and poorer cosmetic outcome. This is a report of excision of MF in multiple quadrants of the breast using a modification of subcutaneous dissection technique dubbed the circumareolar incision and subdermal tunneling (CAST) dissection. After exposure of the superficial fascia with circumareolar incision, subdermal cone-wise dissection was made to allow mobilization of the segment bearing the lump(s)...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28575849/the-nucleocytoplasmic-translocation-and-up-regulation-of-ing5-protein-in-breast-cancer-a-potential-target-for-gene-therapy
#6
Xiao-Qing Ding, Shuang Zhao, Lei Yang, Xin Zhao, Gui-Feng Zhao, Shu-Peng Zhao, Zhi-Jie Li, Hua-Chuan Zheng
Here, we found that ING5 overexpression resulted in a lower proliferation, reduced glucose metabolism, S arrest, decreased migration and invasion, apoptotic induction, fat accumulation, autophagy, senescence and mesenchymal-epithelial-transition of breast cancer cells. It also suppressed the tumor growth of breast cancer cells by inhibiting proliferation, inducing apoptosis and autophagy. ING5-mediated chemoresistance was positively linked to Akt and NF-κB activation, MRP1 and GST-π overexpression, and FBXW7 hypoexpression...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574223/advantages-of-the-modified-double-ring-areolar-incision-over-the-traditional-areolar-incision-in-multicentric-breast-fibroadenoma-surgery
#7
Mingliang Zhang, Gongjin Shen, Song Zhang, Zhen Cui, Jun Qian
BACKGROUND: This study was conducted to investigate the clinical advantages of modified double ring areola incision (MDRAI) compared to ordinary areola incision (OAI) in multicentric breast fibroadenoma in women. METHODS: Sixty cases of multicentric benign breast tumor were recruited from the First Affiliated Hospital of Bengbu Medical College from January to December 2016. The cases were divided into two groups according to surgical approach: MDRAI (n = 20) and OAI (n = 40)...
June 2, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28556594/fibroadenoma-in-adolescent-females-after-living-donor-liver-transplantation
#8
N Tanaka, T Ueno, Y Takama, H Yamanaka, Y Tazuke, K Bessho, H Okuyama
Breast FA is the most common breast tumor diagnosed in young women. Female renal transplant recipients on CsA have an increased risk of developing FA. However, reports of FA after LDLT have not been described. Our objectives were to determine the incidence of FA, analyze risk factors for FA, and evaluate treatment strategies in adolescent females after LDLT. A total of 18 female patients aged 10-19 years who underwent LDLT and survived at least one year after transplantation were enrolled in our study. The incidence of FA was 11...
May 29, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28515586/utility-of-supplemental-screening-with-breast-ultrasound-in-asymptomatic-women-with-dense-breast-tissue-who-are-not-at-high-risk-for-breast-cancer
#9
Geetika A Klevos, Fernando Collado-Mesa, Jose M Net, Monica M Yepes
OBJECTIVE: To assess the results of an initial round of supplemental screening with hand-held bilateral breast ultrasound following a negative screening mammogram in asymptomatic women with dense breast tissue who are not at high risk for breast cancer. MATERIALS AND METHODS: A retrospective, Health Insurance Portability and Accountability Act compliant, Institutional Research Board approved study was performed at a single academic tertiary breast center. Informed consent was waived...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28513873/myxoid-fibroadenomas-differ-from-conventional-fibroadenomas-a-hypothesis-generating-study
#10
John R Lozada, Kathleen A Burke, Aoife Maguire, Fresia Pareja, Raymond S Lim, Jisun Kim, Rodrigo Gularte-Merida, Melissa P Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho, Felipe C Geyer
AIMS: Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney Complex, an inheritable condition caused by PRKAR1A inactivating germline mutations. Conventional fibroadenomas (FAs) are underpinned by recurrent MED12 mutations in the stromal components of the lesions. We sought to investigate the genomic landscape of MFAs and compare it to that of conventional FAs. METHODS AND RESULTS: Eleven MFAs from patients without clinical and/or genetic evidence of Carney Complex were retrieved...
May 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28511397/fibroadenoma-in-axillary-ectopic-breast-tissue-mimicking-lymphadenopathy
#11
Pooja Kamlesh Gajaria, Ujwala M Maheshwari
Swellings in the axilla especially in women are always viewed with suspicion owing to a large number of these being associated with breast carcinoma presenting as nodal metastasis. In a country like India, tuberculous lymphadenopathy is also amongst the first differentials. We present a case of a woman with right sided axillary swelling mimicking lymphadenopathy which on Fine Needle Aspiration Cytology (FNAC) turned out to be fibroadenoma of the ectopic breast tissue. This condition is a rare occurrence in Ectopic Breast Tissue (EBT) as opposed to that in the normal breast, the most common pathology affecting ectopic breast being carcinomas...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28472777/anesthetic-dreaming-anesthesia-awareness-and-patient-satisfaction-after-deep-sedation-with-propofol-target-controlled-infusion-a-prospective-cohort-study-of-patients-undergoing-day-case-breast-surgery
#12
Marco Cascella, Roberta Fusco, Domenico Caliendo, Vincenza Granata, Domenico Carbone, Maria Rosaria Muzio, Giuseppe Laurelli, Stefano Greggi, Francesca Falcone, Cira Antonietta Forte, Arturo Cuomo
BACKGROUND: Anesthetic dreaming and anesthesia awareness are well distinct phenomena. Although the incidence of intraoperative awareness is more common among patients who reported a dream after surgery, the exact correlation between the two phenomena remains an unsolved rebus. The main purpose of this study was to investigate anesthetic dreaming, anesthesia awareness and psychological consequences eventually occurred under deep sedation. Intraoperative dreaming experiences were correlated with dream features in natural sleep...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472030/combination-of-shear-wave-elastography-and-color-doppler-feasible-method-to-avoid-unnecessary-breast-excision-of-fibroepithelial-lesions-diagnosed-by-core-needle-biopsy
#13
Ga Ram Kim, Ji Soo Choi, Boo-Kyung Han, Eun Young Ko, Eun Sook Ko, Soo Yeon Hahn
BACKGROUND: We evaluated shear-wave elastography (SWE) and color Doppler ultrasonography (US) features for fibroepithelial lesions (FELs), and to evaluate their utility to differentiate fibroadenomas (FAs) and phyllodes tumors (PTs). METHODS: This retrospective study included 67 FELs pathologically confirmed (49 FAs, 18 PTs). B-mode US, SWE and color Doppler US were performed for each lesion. Mean elasticity (Emean), maximum elasticity (Emax), and vascularity were determined by SWE and Doppler US...
2017: PloS One
https://www.readbyqxmd.com/read/28466794/-fibroepithelial-tumours-of-the-breast-not-always-a-simple-fibroadenoma
#14
V A van de Graaf, C A L de Raaff, A W Walter, M N Weimann, B C Vrouenraets
Fibroepithelial tumours are the most common type of solid breast tumours. They include the common fibroadenomas and the rare phyllodes tumours. Fibroadenomas usually present in younger patients and are smaller than phyllodes tumours. They are benign and do not require any treatment or follow-up. Further examination (usually ultrasound-guided thick-needle biopsy) is recommended if in doubt about the diagnosis. Phyllodes tumours can be divided into benign, borderline and malignant tumours and are primarily treated with surgery, breast-conserving surgery if possible...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28463909/fibroadenoma-like-lesion-of-the-vagina-a-description-of-2-cases-of-a-previously-unreported-entity
#15
Michelle Moore, Michael McKenna, Srinivas Mandavilli, W Glenn McCluggage
We report 2 cases of a previously undescribed vaginal lesion, which we term "fibroadenoma-like lesion of the vagina" because of the close morphologic resemblance to breast fibroadenoma. Both lesions arose in the upper vagina and exhibited a biphasic appearance with benign epithelial and stromal elements. The glandular epithelium comprised a double layer of luminal and basal cells with focal squamous differentiation in 1 case. The stromal component was fibroblastic and morphologically bland for the most part, although occasional atypical symplastic-like cells were present in 1 case...
April 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28462850/epstein-barr-virus-infection-and-breast-invasive-ductal-carcinoma-in-egyptian-women-a-single-center-experience
#16
Noha Ed Hassab El-Naby, Hameda Hassan Mohamed, Asmaa Mohamed Goda, Ahmed El Sayed Mohamed
BACKGROUND: A controversy of the role of Epstein-Barr virus (EBV) infection in breast carcinomas has been reported in the literature. OBJECTIVES: We carried on this research to explore possible association between EBV infection and breast invasive ductal carcinoma (IDC) in Egyptian women attending our center. STUDY DESIGN: This study carried out at Sohag university hospital on 84 paraffin embedded samples of breast tissue, of them 42 breast IDC as the case group and 42 breast fibroadenomas as the control group...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28458828/giant-phyllodes-tumor-of-the-breast-with-diffuse-myxoid-changes-in-an-adolescent-girl-a-case-report
#17
Ji Young Lee
Giant phyllodes tumors (PT) are an uncommon fibroepithelial neoplasm and especially rare in adolescent girls. Diagnosis is difficult not only due to the rarity of PT, but also owing to the resemblance of its clinical and imaging features with fibroadenoma. The author reports a case of a giant PT in a 14-year-old girl. Clinical examination showed a large painful mass in the left breast, and an abscess was initially suspected. But magnetic resonance imaging (MRI) displayed features characteristic of PT. Following complete surgical excision of the mass, histopathology confirmed the diagnosis of a benign PT with diffuse myxoid changes, consistent with the MRI findings...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28454081/expression-characteristic-of-cxcr1-in-different-breast-tissues-and-the-relevance-between-its-expression-and-efficacy-of-neo-adjuvant-chemotherapy-in-breast-cancer
#18
Miao-Qun Xue, Jun Liu, Jian-Feng Sang, Lei Su, Yong-Zhong Yao
OBJECTIVE: To investigate chemokine receptor CXCR1 expression characteristic in different breast tissues and analyze the relationship between CXCR1 expression changes in breast cancer tissue and efficacy of neo-adjuvant chemotherapy. RESULTS: Chemokine receptor CXCR1 was lowly expressed in normal breast tissues and breast fibroadenoma, but highly expressed in breast cancer. It was significantly correlated with pathological stage, tumor cell differentiation, and lymph node metastasis (P < 0...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413897/fibroadenoma-with-pleomorphic-stromal-giant-cells-it-s-not-as-bad-as-it-looks
#19
Jonathan Wawire, Kamaljeet Singh, Margaret M Steinhoff
Clinically relevant histological categorization of fibroepithelial lesions can be a daunting task, especially in a core needle biopsy. Assessment of stromal nuclear atypia, including nuclear pleomorphism and mitotic activity, is a key morphological feature employed to classify fibroepithelial lesions. We describe a case of fibroadenoma with markedly atypical nuclear features in the stromal cells that led to misclassification as phyllodes tumor in the core needle biopsy. Excision showed a fibroadenoma containing pleomorphic stromal giant cells, with occasional mitotic figures, including atypical forms...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28395232/laser-interstitial-thermotherapy-application-for-breast-surgery-current-situation-and-new-trends
#20
REVIEW
Yohan Kerbage, Nacim Betrouni, Pierre Collinet, Henri Azaïs, Serge Mordon, Anne-Sophie Dewalle-Vignion, Benjamin Merlot
While breast specialists debate on therapeutic de-escalation in breast cancer, the treatment of benign lesions is also discussed in relation to new percutaneous ablation techniques. The purpose of these innovations is to minimize potential morbidity. Laser Interstitial ThermoTherapy (LITT) is an option for the ablation of targeted nodules. This review evaluated the scientific publications investigating the LITT approach in malignant and benign breast disease. Three preclinical studies and eight clinical studies (2 studies including fibroadenomas and 6 studies including breast cancers) were reviewed...
June 2017: Breast: Official Journal of the European Society of Mastology
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