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Fibroadenoma

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https://www.readbyqxmd.com/read/28688536/fibroepithelial-lesions-the-who-spectrum
#1
REVIEW
Gregor Krings, Gregory R Bean, Yunn-Yi Chen
Fibroepithelial lesions of the breast comprise a morphologically and biologically heterogeneous group of biphasic tumors with epithelial and stromal components that demonstrate widely variable clinical behavior. Fibroadenomas are common benign tumors with a number of histologic variants, most of which pose no diagnostic challenge. Cellular and juvenile fibroadenomas can have overlapping features with phyllodes tumors and should be recognized. Phyllodes tumors constitute a spectrum of lesions with varying clinical behavior and are graded as benign, borderline or malignant based on a set of histologic features according to recommendations by the World Health Organization (WHO)...
May 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28687686/isolated-insulin-derived-amyloidoma-of-the-breast
#2
Jonathan Mark Mayhew, Tanya Alan, Venu Kalidindi, Tasha A K Gandamihardja
Isolated amyloidomas derived from insulin are extremely rare, and there is only one reported case to date of insulin-derived amyloidoma in the breast.We present the case of a 36-year-old woman reporting a lump in the right breast. It was clinically assessed as a probable fibroadenoma but was removed surgically given the size of the lesion. On histological analysis, the lesion had features consistent with amyloid. Further investigations showed the amyloid to be derived from insulin. The lump was removed in its entirety, and the patient made a full recovery...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28687161/deregulation-of-mir-126-3p-in-basal-like-breast-cancers-stroma-and-its-clinical-significance
#3
Jing Li, Jin Liang Ping, Bo Ma, Ying Rong Chen, Li Qin Li
INTRODUCTION: The aim of this study was to investigate miR-126-3p expression in stroma and tumor cells of basal-like breast cancer tissues, in an effort to elucidate the potential effect of miR-126-3p on tumor microenvironment and progress of basal-like breast cancer. METHODS: Expression levels of miR-126-3p in 33 paired basal-like breast cancer tissues were assayed by real-time quantitative PCR. Tumor cells and normal epithelial cell were isolated from ten paired basal-like breast cancer tissues and matched adjacent tissues, separately, using laser capture microdissect(LCM)-based PCR method...
May 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28685877/availability-of-immunocytochemistry-using-cocktail-antibody-targeting-p63-cytokeratin14-for-the-differential-diagnosis-of-fibroadenoma-and-ductal-carcinoma-in-situ-in-fine-needle-aspiration-cytology-of-the-breast
#4
I Maeda, Y Oana, K Tsugawa, M Takagi
OBJECTIVE: The differential diagnosis of fibroadenoma (FA) and ductal carcinoma in situ (DCIS) has been problematic in fine needle aspiration biopsy (FNAC) because it has been difficult to differentiate between the "large epithelial clusters" associated with FA and those associated with DCIS. The purpose of this study was to prospectively validate the usefulness of immunocytochemical staining using cocktail antibody targeting p63/CK14 in the differential diagnosis of FA and DCIS. MATERIALS AND METHODS: Twenty patients diagnosed as having an uncertain malignant potential (indeterminate) for breast cancer on the basis of a FNAC finding were selected randomly: ten patients with FA and ten with DCIS...
July 6, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28663913/plum-pudding-random-medium-model-of-biological-tissue-toward-remote-microscopy-from-spectroscopic-light-scattering
#5
Min Xu
Biological tissue has a complex structure and exhibits rich spectroscopic behavior. There has been no tissue model until now that has been able to account for the observed spectroscopy of tissue light scattering and its anisotropy. Here we present, for the first time, a plum pudding random medium (PPRM) model for biological tissue which succinctly describes tissue as a superposition of distinctive scattering structures (plum) embedded inside a fractal continuous medium of background refractive index fluctuation (pudding)...
June 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28658847/massive-benign-phyllodes-tumour-of-breast-complicating-pregnancy
#6
Anji Reddy Kallam, Vandana Kanumury, Rama Murthy Korumilli, Vahini Gudeli, Havya Polavarapu
Phyllodes tumour of the breast, earlier called cystosarcomaphyllodes, is a rare fibroepithelial breast neoplasm that occurs in all age groups from adolescents to elderly. Phyllodes tumour occurring during pregnancy and associated with lactating breast is extremely rare. Giant phyllodes tumours or giant fibroadenomas are those measuring more than 10 cms in diameter and weighing more than 500 gm. Phyllodes tumour typically exhibits an exclusive intracanalicular growth pattern of fibroepithelial cells with classical, deep leaf-like stromal projections into dilated lumens from which its name "phyllodes" is derived...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655120/a-rare-benign-tumor-of-breast-masquerading-on-fine-needle-aspiration-cytology-a%C3%A2-case%C3%A2-report
#7
Banushree Cs, Ramachandra V Bhat, Sri Vengadesh Gopal
Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. We present an extremely rare case of pleomorphic adenoma of breast diagnosed on FNAC with histopathological confirmation.
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655118/giant-juvenile-fibroadenoma-in-a-9-year-old-a-case-presentation-and-review-of-the-current-literature
#8
Michalina Kupsik, Brian Yep, Suela Sulo, Heidi Memmel
Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. They are defined as being larger than 5 cm or weighing more than 500 g. The peak age has been reported between the ages of 17 and 20, with less than 5% of these in patients less than 18-years-old.We present a 9-year-old, pre-menstrual, Nigerian female with no known family history of breast masses or cancers who developed spontaneous giant fibroadenoma measuring approximately 13  cm × 13 cm...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28648934/molecular-alterations-in-lesions-of-anogenital-mammary-like-glands-and-their-mammary-counterparts-including-hidradenoma-papilliferum-intraductal-papilloma-fibroadenoma-and-phyllodes-tumor
#9
Anastasia M Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V Spagnolo, Colin J R Stewart, Francesca Portelli, Michal Michal, Dmitry V Kazakov
Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28646155/breast-cancer-multi-classification-from-histopathological-images-with-structured-deep-learning-model
#10
Zhongyi Han, Benzheng Wei, Yuanjie Zheng, Yilong Yin, Kejian Li, Shuo Li
Automated breast cancer multi-classification from histopathological images plays a key role in computer-aided breast cancer diagnosis or prognosis. Breast cancer multi-classification is to identify subordinate classes of breast cancer (Ductal carcinoma, Fibroadenoma, Lobular carcinoma, etc.). However, breast cancer multi-classification from histopathological images faces two main challenges from: (1) the great difficulties in breast cancer multi-classification methods contrasting with the classification of binary classes (benign and malignant), and (2) the subtle differences in multiple classes due to the broad variability of high-resolution image appearances, high coherency of cancerous cells, and extensive inhomogeneity of color distribution...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631431/phaeohyphomycosis-breast-masquerading-as-fibroadenoma-in-a-young-teenage-girl
#11
Amita Jain Gupta, Meeta Singh, Surekha Yadav, Nita Khurana, Shyam Lata Jain, Rohit Chawla, Sunil Laka, Anurag Mishra
Phaeohyphomycosis is an unusual granulomatous fungal infection, observed in immunocompromised or diabetic patients; however, it is even rarer in immunocompetent patients. Cytological findings of the same have been infrequently reported. The histopathological diagnosis or fungal culture helps in definitive diagnosis to identify the exact fungal species. Hereby, we report a rare case of invasive fungal infection in a breast lump in a young female, presenting as fibroadenoma breast. Fine needle aspiration cytology from the breast lesion showed the presence of septate acute-angled branching fungal hyphae with focal pigmentation, morphologically suggestive of phaeohyphomycosis which was positive with fungal stains...
June 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28623243/metaplastic-breast-carcinoma-with-chondroid-differentiation-a-rare-variant-of-infiltrative-carcinoma-in-a-38-year-old-woman
#12
Shokouh Taghipour Zahir, Mostafa Javannejad
Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28608564/b-acute-lymphoblastic-leukemia-lymphoma-involving-pre-existing-fibroadenoma-of-the-breast
#13
Mayur Kothiya, Tanuja Shet, Shalaka Joshi, Hasmukh Jain, Seema Kembhavi, Sangeeta Desai
No abstract text is available yet for this article.
June 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28584621/fibroadenoma-progress-to-ductal-carcinoma-in-situ-infiltrating-ductal-carcinoma-and-lymph-node-metastasis-report-an-unusual-case
#14
Yu-Ting Wu, Hua-Koon Wu, Shou-Tung Chen, Chih-Jung Chen, Dar-Ren Chen, Hung-Wen Lai
Fibroadenoma of the breast is the most common benign neoplasm in young women who present with a palpable, movable mass. Malignancy inside fibroadenomas is rare, with reported rates ranging from 0.002% to 0.125%. Carcinoma in situ inside a fibroadenoma is usually found incidentally when tumours are excised. Whether fibroadenoma is a risk factor for breast cancer remains controversial. Due to the rarity of carcinomas inside fibroadenomas, medical institutes have little experience with this phenomenon. We report an unusual case in which progression occurred from benign fibroadenoma to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis...
May 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28584515/circumareolar-incision-subdermal-tunneling-dissection-for-excision-of-multiple-breast-fibroadenomata
#15
S O Agodirin, G A Rahman, S A Olatoke, H J Akande
Excision of multiple fibroadenomas (MF) in separate breast quadrants presents difficulties of number and location of incision(s) and extent of tissue dissection and may be associated with more complications and poorer cosmetic outcome. This is a report of excision of MF in multiple quadrants of the breast using a modification of subcutaneous dissection technique dubbed the circumareolar incision and subdermal tunneling (CAST) dissection. After exposure of the superficial fascia with circumareolar incision, subdermal cone-wise dissection was made to allow mobilization of the segment bearing the lump(s)...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28575849/the-nucleocytoplasmic-translocation-and-up-regulation-of-ing5-protein-in-breast-cancer-a-potential-target-for-gene-therapy
#16
Xiao-Qing Ding, Shuang Zhao, Lei Yang, Xin Zhao, Gui-Feng Zhao, Shu-Peng Zhao, Zhi-Jie Li, Hua-Chuan Zheng
Here, we found that ING5 overexpression resulted in a lower proliferation, reduced glucose metabolism, S arrest, decreased migration and invasion, apoptotic induction, fat accumulation, autophagy, senescence and mesenchymal-epithelial-transition of breast cancer cells. It also suppressed the tumor growth of breast cancer cells by inhibiting proliferation, inducing apoptosis and autophagy. ING5-mediated chemoresistance was positively linked to Akt and NF-κB activation, MRP1 and GST-π overexpression, and FBXW7 hypoexpression...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574223/advantages-of-the-modified-double-ring-areolar-incision-over-the-traditional-areolar-incision-in-multicentric-breast-fibroadenoma-surgery
#17
Mingliang Zhang, Gongjin Shen, Song Zhang, Zhen Cui, Jun Qian
BACKGROUND: This study was conducted to investigate the clinical advantages of modified double ring areola incision (MDRAI) compared to ordinary areola incision (OAI) in multicentric breast fibroadenoma in women. METHODS: Sixty cases of multicentric benign breast tumor were recruited from the First Affiliated Hospital of Bengbu Medical College from January to December 2016. The cases were divided into two groups according to surgical approach: MDRAI (n = 20) and OAI (n = 40)...
June 2, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28556594/fibroadenoma-in-adolescent-females-after-living-donor-liver-transplantation
#18
N Tanaka, T Ueno, Y Takama, H Yamanaka, Y Tazuke, K Bessho, H Okuyama
Breast FA is the most common breast tumor diagnosed in young women. Female renal transplant recipients on CsA have an increased risk of developing FA. However, reports of FA after LDLT have not been described. Our objectives were to determine the incidence of FA, analyze risk factors for FA, and evaluate treatment strategies in adolescent females after LDLT. A total of 18 female patients aged 10-19 years who underwent LDLT and survived at least one year after transplantation were enrolled in our study. The incidence of FA was 11...
May 29, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28515586/utility-of-supplemental-screening-with-breast-ultrasound-in-asymptomatic-women-with-dense-breast-tissue-who-are-not-at-high-risk-for-breast-cancer
#19
Geetika A Klevos, Fernando Collado-Mesa, Jose M Net, Monica M Yepes
OBJECTIVE: To assess the results of an initial round of supplemental screening with hand-held bilateral breast ultrasound following a negative screening mammogram in asymptomatic women with dense breast tissue who are not at high risk for breast cancer. MATERIALS AND METHODS: A retrospective, Health Insurance Portability and Accountability Act compliant, Institutional Research Board approved study was performed at a single academic tertiary breast center. Informed consent was waived...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28513873/myxoid-fibroadenomas-differ-from-conventional-fibroadenomas-a-hypothesis-generating-study
#20
John R Lozada, Kathleen A Burke, Aoife Maguire, Fresia Pareja, Raymond S Lim, Jisun Kim, Rodrigo Gularte-Merida, Melissa P Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho, Felipe C Geyer
AIMS: Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Conventional fibroadenomas (FAs) are underpinned by recurrent MED12 mutations in the stromal components of the lesions. The aim of this study was to investigate the genomic landscape of MFAs and compare it with that of conventional FAs. METHODS AND RESULTS: Eleven MFAs from patients without clinical and/or genetic evidence of Carney complex were retrieved...
May 17, 2017: Histopathology
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