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https://www.readbyqxmd.com/read/29322796/pitfalls-of-contrast-enhanced-ultrasound-ceus-in-determination-of-breast-tumor-biological-dignity
#1
V Lehotska, K Rauova, L Vanovcanova
The aim of this prospective study was to identify characteristics of breast lesions on contrast enhanced ultrasound (CEUS) that can be a source of diagnostic ambiguity and cause under- or overestimation of examined breast lesions. 215 women (range 23-76 y., mean age 53.16 y) with 215 breast lesions were examined by B-mode ultrasound, followed by CEUS and core biopsy. CEUS parameters: degree of opacification, character of washout and preliminary CEUS result (suspicious, non-suspicious, uncertain) were subsequently correlated with histopathological outcomes...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322120/juvenile-papillomatosis-of-the-breast-in-a-pre-pubertal-girl-an-uncommon-diagnosis
#2
Mehmet Tolga Kafadar, Zeynep Anadolulu, Ali İhsan Anadolulu, Emine Zeynep Tarini
Juvenile papillomatosis of the breast represents a rare benign proliferative disorder that affects women younger than thirty years of age. Although it is a localized lesion, it does not have well-demarcated margins. These patients tend to have a strong family history for cancer. As it has similar clinical presentation with that of a fibroadenoma, it usually receives the diagnosis of the latter in the preoperative period. Nonetheless, it has distinct microscopic features such as ductal papillomatosis and cysts that are helpful in the diagnosis...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29322112/managing-male-mammary-maladies
#3
REVIEW
Ian S Fentiman
This review examines the symptoms, need for referral and management of the benign breast conditions which afflict males, together with the steps that are necessary to exclude or confirm male breast cancer. The most common complaint is gynaecomastia, either true or pseudo, and the majority of these cases need reassurance without over-investigation. Drugs that induce breast enlargement are described in order that, when possible, a medication switch can be made. Men receiving endocrine therapy for prostate cancer may develop painful gynaecomastia and this can be relieved with tamoxifen...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29316031/ultrasonographic-assessment-of-male-breast-diseases
#4
Xueyu Rong, Qiang Zhu, Wenxiu Jia, Teng Ma, Xixi Wang, Ning Guo, Hongtao Ji
Although rare and accounting for less than 1% of all breast cancers, the incidence of breast cancer in men has increased by 26% over the past few decades. Very little has been reported on the sonographic appearance of benign and malignant male breast conditions. The aim of this study was to describe the ultrasonographic features of male breast disease and the value of ultrasound in the evaluation of male breast disease. Between December 2006 and October 2014, ultrasound examinations were performed in 560 male patients presenting with enlargement of, pain in, and/or a lump in the breast...
January 8, 2018: Breast Journal
https://www.readbyqxmd.com/read/29315289/med12-tert-promoter-and-rbm15-mutations-in-primary-and-recurrent-phyllodes-tumours
#5
Diego A Garcia-Dios, Dina Levi, Vandna Shah, Cheryl Gillett, Michael A Simpson, Andrew Hanby, Ian Tomlinson, Elinor J Sawyer
BACKGROUND: MED12 and TERT promoter mutations have been shown to be the most common somatic mutations in phyllodes tumours (PTs). The aims of this study were to determine the frequency of these mutations in recurrent PTs, assess whether TERT promoter mutations could be helpful in distinguishing fibroadenomas (FAs) from PTs and identify novel mutations that may be driving malignant progression. METHODS: MED12 and the TERT promoter were Sanger sequenced in 75 primary PTs, 21 recurrences, 19 single FAs and 2 cases of multiple FAs with benign PTs...
January 9, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29302481/development-of-a-surgical-algorithm-by-using-pre-operative-imaging-to-predict-mammoplasty-cosmetic-outcomes-for-large-non-malignant-tumours
#6
Geok-Hoon Lim, Ruey Pyng Ng, Lester Chee Hao Leong
Background: Use of mammoplasty for resection of large non-malignant tumours is not widely described. We aim to determine the optimal tumour to breast size ratio cut-off in this group of patients undergoing mammoplasty which could achieve satisfactory cosmetic outcomes. Methods: Patients who underwent mammoplasty from May 2014 to June 2017 for biopsy-proven large non-malignant tumours were included in the study. The demographics, tumour to breast size ratios, histological features and cosmetic outcomes of these patients were assessed...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29290198/progression-of-fibroadenoma-to-malignant-phyllodes-tumour-in-a-14-year-female
#7
Shahbaz Habib Faridi, Bushra Siddiqui, Syed Shamshad Ahmad, Mohammad Aslam
Phyllodes tumours are uncommon breast tumours which account for less than 1% of all breast neoplasms. High-grade malignant phyllodes tumour is a very rare but aggressive breast malignancy and forms approximately 15-30% of all phyllodes tumours. The transformation of a benign fibroadenoma into a malignant phyllodes tumour in a teenaged female is even rarer. We report here an interesting case of malignant phyllodes tumour in a 14-year female patient who was operated twice previously with the diagnosis of complex fibroadenoma in the same breast...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29286912/cytological-diagnosis-of-crystallizing-galactocele-report-of-an-unusual-case
#8
Mohammad Jaseem Hassan, Monika Sharma, Shaan Khetrapal, Sabina Khan, Sujata Jetley
Crystallizing galactocele is a very rare entity which yields a viscous, chalky material on Fine Needle Aspiration Cytology (FNAC). FNAC is used both for diagnosis as well as treatment of this condition. We present here a case of 26 years old lactating female who presented with swelling in the right breast for 8 months. The swelling was firm, discrete, non-tender and mobile involving the upper inner quadrant of right breast. A diagnosis of benign breast disease, possibly fibroadenoma was made clinically. FNAC of the lesion yielded thick, milky and chalky material...
December 28, 2017: Breast Disease
https://www.readbyqxmd.com/read/29286226/almost-complete-lack-of-human-cytomegalovirus-and-human-papillomaviruses-genome-in-benign-and-malignant-breast-lesions-in-shiraz-southwest-of-iran
#9
Sahar Bakhtiyrizadeh, Seyed Younes Hosseini, Ramin Yaghobi, Aliakbar Safaei, Jamal Sarvari
Breast cancer ranks as the most common cancer among women worldwide. There have been controversial reports regarding contributions of human papillomaviruses (HPVs) and human cytomegalovirus (HCMV) to its development. The aim of this study was to determine the frequency of HPV and HCMV positivity in benign and malignant breast tumors. Materials and Methods: Formalin fixed paraffin-embedded tissue specimens of 150 breast cancers (invasive ductal and lobular carcinomas) and 150 non-malignant breast lesions (fibroadenomas, fibrocystic disease and adenosis) were examined...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29285483/an-evaluation-of-ultrasound-features-of-breast-fibroadenoma
#10
Alireza Namazi, Atoosa Adibi, Mahshid Haghighi, Morteza Hashemi
Background: Breast cancer is among the most common cancers in the world. Ultrasound evaluations of breast have come into attention as an alternative route. Ultrasound features of benign lesions such as fibroadenoma can be overlapping with those in a malignant tumor. Here, we assessed the reports of breast ultrasound in patients with pathologic diagnosis of fibroadenoma. Materials and Methods: We conducted a cross-sectional study and enrolled female patients with confirmed histologic diagnosis of fibroadenoma...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29285241/golph3-a-novel-biomarker-that-correlates-with-poor-survival-and-resistance-to-chemotherapy-in-breast-cancer
#11
Shicong Tang, Hong Pan, Wei Wei, Huawei Yang, Jianlun Liu, Rirong Yang
The association between Golgi phosphoprotein 3 (GOLPH3) and clinical pathological characteristics, as well as the clinical outcomes of both neoadjuvant and adjuvant chemotherapies in breast cancer, remain largely unknown. In this study, we investigated the biological role and clinical significance of GOLPH3 in breast cancer. We found that GOLPH3 expression in tumor tissue was higher than that in adjacent noncancerous tissue (ANT) and fibroadenoma. GOLPH3 silencing reduced the migration, invasion, and proliferation of breast cancer cells and promoted apoptosis of the cells...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29279734/usefulness-of-organ-electrodermal-diagnostics-in-detection-of-breast-pathology-a-multicenter-randomized-double-blinded-clinical-study
#12
Jan Z Szopinski, Sarah Rayne
Objective: Pathology of an internal organ/body part causes corresponding skin areas-organ projection areas/acupuncture points-to rectify applied electrical currents (a diode phenomenon) once the resistance "breakthrough effect" has been induced in these specific, and sometimes remote, skin zones. The aim of this study was to estimate the diagnostic accuracy-as well as the scope of utilization-for detection of breast pathology of organ electrodermal diagnostics (OED), which utilizes this electrophysiologic phenomenon...
December 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29276871/evaluation-of-surgically-treated-breast-masses-in-children
#13
Gül Doğan, Tutku Soyer, Saniye Ekinci, İbrahim Karnak, Arbay Ö Çiftçi, Feridun C Tanyel
Doğan G, Soyer T, Ekinci S, Karnak İ, Çiftçi AÖ, Tanyel FC. Evaluation of surgically treated breast masses in children. Turk J Pediatr 2017; 59: 177-183. We aimed to define the diagnostic and treatment characteristics of breast masses among female children who had undergone surgical treatment in order to figure out which children should be followed conservatively or treated surgically. We reviewed retrospectively 64 female patients operated for breast masses under the age of 18 years between 1977 and 2013...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29248888/genetics-and-genomics-of-breast-fibroadenomas
#14
REVIEW
Benjamin Nathanael Loke, Nur Diyana Md Nasir, Aye Aye Thike, Jonathan Yu Han Lee, Cheok Soon Lee, Bin Tean Teh, Puay Hoon Tan
Fibroadenomas of the breast are benign fibroepithelial tumours most frequently encountered in women of reproductive age, although they may be diagnosed at any age. The fibroadenoma comprises a proliferation of both stromal and epithelial components. The mechanisms underlying fibroadenoma pathogenesis remain incompletely understood. In the clinical setting, distinguishing cellular fibroadenomas from benign phyllodes tumours is a common diagnostic challenge due to subjective histopathological criteria and interobserver differences...
December 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29247967/early-stage-malignant-phyllodes-tumor-case-report
#15
Thao Wolbert, Emilia C N Leigh, Rahman Barry, Jack R Traylor, Mary Legenza
INTRODUCTION: Malignant phyllodes tumor of the breast is an extremely rare entity usually presenting with similar clinical features with those of benign fibroadenoma. Due to its scarcity and clinical presentation, it is quite difficult for clinicians to suspect and diagnose the disease at its early stage. There is currently no consensus regarding adjunctive radiotherapy, hormonal therapy and systemic chemotherapy recommended for malignant phyllodes tumors. PRESENTATION OF CASE: This report presents a case of early-stage malignant phyllodes tumor treated by lumpectomy only without adjunctive chemoradiation therapy, but with an excellent outcome...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245318/recurrent-malignant-phyllodes-tumor-of-the-breast-a-case-report
#16
Qinqin Wang, Jing Su, Yutao Lei
RATIONALE: Phyllodes tumor is a rare fibro epithelial neoplasm of the breast. They resemble fibroadenomas clinically and can be mistakenly ignored sometimes. PATIENT CONCERNS: We report the case of a young woman with her first presentation to hospital due to a hypoglycemia and she underwent 2 excised fibroadenomas in the same breast before diagnosed of malignant phyllodes tumor. She was complaining about 2 masses presented in her right breast 4 months after mastectomy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29231040/differentiation-between-phyllodes-tumors-and-fibroadenomas-using-intravoxel-incoherent-motion-magnetic-resonance-imaging-comparison-with-conventional-diffusion-weighted-imaging
#17
Hiroko Kawashima, Tosiaki Miyati, Naoki Ohno, Masako Ohno, Masafumi Inokuchi, Hiroko Ikeda, Toshifumi Gabata
OBJECTIVE: To investigate whether the parameters derived from intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) could differentiate phyllodes tumors (PTs) from fibroadenomas (FAs) by comparing the apparent diffusion coefficient (ADC) values. METHODS: This retrospective study included seven FAs, 10 benign PTs (BPTs), four borderline PTs, and one malignant PT. Biexponential analyses of IVIM were performed using a 3 T MRI scanner. Quantitative IVIM parameters (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) were calculated...
December 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29207805/benign-lesions-on-screening-mammography-increasing-diagnostic-confidence-in-a-hitherto-unscreened-population
#18
Piyush Joshi, Rohit Sharma
Introduction: Screening mammography is used for detection of breast cancer and is interpreted using the Breast Image Reporting and Data System (BIRADS) convention. It is not routinely offered to women in countries which do not have a national screening programme resulting in a challenge for the radiologist who has to interpret these in the absence of previous mammograms. Aim: To analyse benign and probably benign lesions in screening mammograms in a hitherto unscreened population and suggest protocols to increase diagnostic confidence...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29187920/-benign-tumors-of-the-breast-in-the-department-of-senology-at-the-university-hospital-aristide-le-dantec-dakar-senegal
#19
Serigne Modou Kane Gueye, Mamour Gueye, Mariétou Thiam Coulibaly, Diana Mahtouk, Jean Charles Moreau
Introduction: This study aimed to identify the epidemiological, clinical and therapeutic features of benign tumors of the breast treated in the department of senology at the university hospital Aristide Le Dantec, Dakar. Methods: We conducted a cross-sectional, descriptive and analytical study of 220 patients treated in the Department of Senology at the University Hospital Aristide Le Dantec, Dakar over the period from 1 January 2008 to 31 December 2013. Results: 220 patients out of 984 consultants had benign tumor of the breast (22...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29169272/a-case-of-benign-phyllodes-tumor-in-a-transgender-woman-receiving-cross-sex-hormones
#20
Stephanie M Richards, Elyse D Pine-Twaddell, Olga B Ioffe, Emily C Bellavance
Phyllodes tumor is a relatively uncommon fibroepithelial neoplasm of the breast characterized by proliferation of both stromal and epithelial elements. Benign phyllodes tumors are distinguished from fibroadenomas by their prominent leaf-like architecture and exaggerated intracanalicular stromal growth pattern. Typically, these lesions affect older natal females; however, we present what we believe is the first reported case of benign phyllodes tumor in a hormonally treated transgender woman.
November 1, 2017: International Journal of Surgical Pathology
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