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Cooper PS

Kenichiro Kakutani, Yoshitada Sakai, Koichiro Maeno, Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Miyazaki, Yoshiki Terashima, Masaaki Ito, Hitomi Hara, Teruya Kawamoto, Yasuo Ejima, Akihiro Sakashita, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihro Akisue, Hironobu Minami, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida
STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known...
October 19, 2016: Clinical Spine Surgery
Masau Sekiguchi, Ichiro Oda, Haruhisa Suzuki, Seiichiro Abe, Satoru Nonaka, Shigetaka Yoshinaga, Hirokazu Taniguchi, Shigeki Sekine, Yutaka Saito
BACKGROUND AND AIMS: Although the number of gastric cancer patients aged ≥85 years indicated for endoscopic submucosal dissection (ESD) has increased, little is known about their outcomes and prognostic factors. This study aimed to investigate the clinical outcomes and factors prognostic of overall survival (OS) of patients aged ≥85 years who underwent ESD for gastric cancer. METHODS: We retrospectively reviewed 108 patients aged ≥85 years with 149 gastric cancers treated by ESD between 1999 and 2014 at our institution...
October 14, 2016: Gastrointestinal Endoscopy
Orsolya E Lunacsek, Arliene Ravelo, Anna D Coutinho, Sebastien J Hazard, Mark R Green, Joanne Willey, Michael Eaddy, Hans-Peter Goertz
BACKGROUND: Real-world evidence is lacking on the impact of bevacizumab added to carboplatin/paclitaxel (Bev + CP) therapy versus CP alone for patients with non-squamous non-small cell lung cancer (NS-NSCLC), particularly in those excluded from clinical trials. METHODS: This is a retrospective electronic medical record analysis of patients who received first-line therapy with Bev + CP or CP between 1 October 2006 and 30 June 2013. We identified four subsets: elderly patients (≥65 years), patients with brain/central nervous system (CNS) metastases, patients with Eastern Cooperative Oncology Group performance status (ECOG PS) ≥2, and patients receiving anticoagulation...
September 2016: Drugs—Real World Outcomes
Priti Xavier, Keerthi M Nair, Lasitha K, Suryasarathi Bose
In this study we have assessed, using dielectric relaxation spectroscopy (DRS), the confinement effects of the more mobile chain in partially miscible polymeric blends of PS/PVME (polystyrene/poly(vinyl methyl ether)) in the presence of anisotropically shaped MWCNTs (multiwalled carbon nanotubes). To understand if this confinement effect is very specific to MWCNTs, the characteristic dimensions of which are often close to the radius of gyration of the polymeric chains, a few other particles like spherical silver, stacked clay tactoids and platy graphene sheets at similar weight fractions were also incorporated and systematically studied...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
David Li, Holly G Prigerson, Josephine Kang, Paul K Maciejewski
CONTEXT: Radiation therapy (RT) is used with palliative intent in patients with advanced stage cancer. Prior studies, primarily in patients with poor performance status (PS), suggest that RT is associated with aggressive medical care, which may impact patients' quality of life near death (QoD) adversely. OBJECTIVE: This study examines associations between RT use and patients' receipt of aggressive care and QoD based on patients' PS. METHODS: Multi-institutional, prospective cohort study of patients with end-stage cancers (N=312) and identified as terminally ill at study enrollment...
October 5, 2016: Journal of Pain and Symptom Management
Takashige Abe, Junji Ishizaki, Hiroshi Kikuchi, Keita Minami, Ryuji Matsumoto, Toru Harabayashi, Ataru Sazawa, Tango Mochizuki, Satoshi Chiba, Tomoshige Akino, Masashi Murakumo, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
AIM: To clarify prognostic factors of metatstatic urothelial carcinoma treated by systemic chemotherapy in real-world clinical practice in the Japanese population. MATERIALS AND METHODS: A total of 228 patients with metastatic urothelial carcinoma undergoing systemic chemotherapy between 2000 and 2013 were included in the present multi-institutional study. The gemcitabine plus cisplatin regimen was administered as first-line chemotherapy to 131 patients, whereas methotrexate, vinblastine, doxorubicin, and cisplatin or its modified regimen was given to 71 patients...
September 29, 2016: Urologic Oncology
Fernando G Zampieri, Fernando A Bozza, Giulliana M Moralez, Débora D S Mazza, Alexandre V Scotti, Marcelo S Santino, Rubens A B Ribeiro, Edison M Rodrigues Filho, Maurício M Cabral, Marcelo O Maia, Patrícia S D'Alessandro, Sandro V Oliveira, Márcia A M Menezes, Eliana B Caser, Roberto S Lannes, Meton S Alencar Neto, Maristela M Machado, Marcelo F Sousa, Jorge I F Salluh, Marcio Soares
PURPOSE: To assess the impact of performance status (PS) impairment 1 week before hospital admission on the outcomes in patients admitted to intensive care units (ICU). METHODS: Retrospective cohort study in 59,693 patients (medical admissions, 67 %) admitted to 78 ICUs during 2013. We classified PS impairment according to the Eastern Cooperative Oncology Group (ECOG) scale in absent/minor (PS = 0-1), moderate (PS = 2) or severe (PS = 3-4). We used univariate and multivariate logistic regression analyses to investigate the association between PS impairment and hospital mortality...
September 29, 2016: Intensive Care Medicine
Jacob N Ablin, Ada H Zohar, Reut Zaraya-Blum, Dan Buskila
OBJECTIVE: The current study is an innovative exploratory investigation, aiming at identifying differences in personality profiles within Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) patients. METHOD: In total, 344 participants (309 female, 35 male) reported suffering from FMS and/or CFS and consented to participate in the study. Participants were recruited at an Israeli FM/CFS patient meeting held in May 2013, and through an announcement posted on several social networks...
2016: PeerJ
Matthew Chan, Kiara Hugh-Yeun, Gillian Gresham, Caroline H Speers, Hagen F Kennecke, Winson Y Cheung
BACKGROUND: We compared the patterns and factors associated with chemotherapy and bevacizumab use in elderly versus young patients with metastatic colon cancer (mCC) and determined the effect of systemic therapy on overall survival (OS) according to age. MATERIALS AND METHODS: Patients diagnosed with mCC from 2009 to 2010 in British Columbia, Canada were reviewed and categorized as elderly patients (age ≥ 70 years) and young patients (age < 70 years). Cox regression models adjusted for age and confounders were used to determine the effect of systemic therapy on OS...
August 30, 2016: Clinical Colorectal Cancer
G Sonpavde, G R Pond, A J Templeton, E D Kwon, J S De Bono
BACKGROUND: Despite palliative benefits and PSA responses, the objective clinical impact of daily oral prednisone (P) for metastatic castration-resistant prostate cancer (mCRPC) is unknown. We performed a pooled analysis of control arms of randomized trials that either did or did not administer single-agent P to evaluate its impact on overall survival (OS) and toxicities. METHODS: Individual patient data from control arms of randomized trials of men with mCRPC who received placebo or P+placebo post docetaxel were eligible for analysis...
September 27, 2016: Prostate Cancer and Prostatic Diseases
Nurul Paramita, Nury Nusdwinuringtyas, Siti Annisa Nuhonni, Tubagus Djumhana Atmakusuma, R Irawati Ismail, Tito R Mendoza, Charles S Cleeland
CONTEXT: Cancer-related fatigue is one of the most commonly reported symptoms in cancer patients. Short but good assessment is essential to detect and manage this symptom. Brief Fatigue Inventory (BFI) is a valid and reliable short instrument to assess cancer-related fatigue. OBJECTIVE: To examine the validity and reliability of the Indonesian BFI. METHODS: Forward and backward translation approach, followed by cognitive debriefing process, was done to develop Indonesian BFI...
September 19, 2016: Journal of Pain and Symptom Management
Avishay Sella, M Dror Michaelson, Ewa Matczak, Ronit Simantov, Xun Lin, Robert A Figlin
BACKGROUND: The Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) models categorize patients with 1 or 2 risk factors as intermediate prognosis (INTMP). This category encompasses 15 and 19 permutations of the MSKCC and IMDC risk factors, respectively. The purpose of the present retrospective analysis of data from INTMP patients in 6 clinical trials was to determine whether this heterogeneity influences the response to sunitinib...
August 18, 2016: Clinical Genitourinary Cancer
Dirk Rades, Theo Veninga, Stefan Janssen, Steven E Schild
BACKGROUND/AIM: To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. PATIENTS AND METHODS: Forty-four patients for whom WBRT was started on a Monday (OTT=5 days) were compared to 136 patients, for whom WBRT was started on another weekday (OTT=7 days; weekend break) regarding intracerebral control and survival. Seven other factors were also analyzed. RESULTS: Intracerebral control at 6 and 12 months was 64% and 36% after OTT of 5 days vs...
September 2016: Anticancer Research
Songyan Zheng, Aastha Puri, Jinjiang Li, Archana Jaiswal, Monica Adams
Micro-flow imaging (MFI) has been used for formulation development for analyzing sub-visible particles. Archimedes, a novel technique for analyzing sub-micron particles, has been considered as an orthogonal method to currently existing techniques. This study utilized these two techniques to investigate the effectiveness of polysorbate (PS-80) in mitigating the particle formation of a therapeutic protein formulation stored in silicone oil-coated pre-filled syringes. The results indicated that PS-80 prevented the formation of both protein and silicone oil particles...
September 12, 2016: AAPS Journal
Tanusree Sengupta, Narayanan Manoj
Protein Z (PZ) is an anticoagulant that binds with high affinity to Protein Z-dependent protease inhibitor (ZPI) and accelerates the rate of ZPI-mediated inhibition of factor Xa (fXa) by more than 1000-fold in the presence of Ca2+ and phospholipids. PZ promotion of the ZPI-fXa interaction results from the anchoring of the Gla domain of PZ onto phospholipid surfaces and positioning the bound ZPI in close proximity to the Gla-anchored fXa, forming a ternary complex of PZ/ZPI/fXa. Although interaction of PZ with phospholipid membrane appears to be absolutely crucial for its cofactor activity, little is known about the binding of different phospholipids to PZ...
2016: PloS One
Hyun Chang, Jisu Oh, Xianglan Zhang, Yu Jung Kim, Jae Ho Lee, Choon-Taek Lee, Jin-Haeng Chung, Jong-Seok Lee
PURPOSE: The aim of this research was to examine the molecular and clinical features that are related with EGFR-tyrosine kinase inhibitor (EGFR-TKI) efficacy in previously treated patients with squamous cell carcinoma of the lung (SCCL). MATERIALS AND METHODS: This retrospective study included 67 SCCL patients with obtainable lung cancer tissue and records on EGFR-TKI treatment response and survival. EGFR protein expression in lung cancer tissue was measured by immunohistochemistry with a specific antibody that recognizes the intracellular domain (ID) of EGFR...
2016: OncoTargets and Therapy
A Deller, A M Alonso, B S Cooper, S D Hogan, D B Cassidy
We report experiments in which positronium (Ps) atoms were guided using inhomogeneous electric fields. Ps atoms in Rydberg-Stark states with principal quantum number n=10 and electric dipole moments up to 610 D were prepared via two-color two-photon optical excitation in the presence of a 670  V cm^{-1} electric field. The Ps atoms were created at the entrance of a 0.4 m long electrostatic quadrupole guide, and were detected at the end of the guide via annihilation gamma radiation. When the lasers were tuned to excite low-field-seeking Stark states, a fivefold increase in the number of atoms reaching the end of the guide was observed, whereas no signal was detected when high-field-seeking states were produced...
August 12, 2016: Physical Review Letters
Guimei Liu, Xinyong Zhang, Cuimeng Tian, Guangrong Xia, Ping Liu, Quan Zhang, Xi Li, Hui Zhang, Na Qin, Jinghui Wang, Shucai Zhang
BACKGROUND: There is no high-level evidence for the time of whole brain radiotherapy (WBRT) for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) and brain metastases. The aim of this study is to assess the appropriate timing of WBRT for patients with EGFR-mutated NSCLC and brain metastases (BM). METHODS: There were 78 patients diagnosed with EGFR-mutated NSCLC and BM in Beijing Chest Hospital between August 2009 and May 2015...
August 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Pascaline Boudou-Rouquette, Camille Tlemsani, Benoit Blanchet, Olivier Huillard, Anne Jouinot, Jennifer Arrondeau, Audrey Thomas-Schoemann, Michel Vidal, Jérôme Alexandre, François Goldwasser
INTRODUCTION: In the past decade, treatment options for metastatic renal cell carcinoma and soft-tissue sarcoma have expanded. Pazopanib was discovered during the screening of compounds that suppressed vascular endothelial growth factor receptor-2 (VEGFR-2). As other tyrosine kinase inhibitors (TKI), pazopanib is not totally specific for one target since it also inhibits stem-cell factor receptor (cKIT), platelet-derived growth factor receptors (PDGFRα, β), VEGFR-1 and -3. AREAS COVERED: Clinical pharmacology, drug-drug interactions and safety data published on pazopanib, between January 2006 and April 2016, are reviewed...
August 24, 2016: Expert Opinion on Drug Metabolism & Toxicology
Michael A Liu, Tammy Hshieh, Nolan Condron, Martha Wadleigh, Gregory A Abel, Jane A Driver
BACKGROUND: Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS: Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreement of Eastern Cooperative Oncology Group PS using weighted κ-statistics and survival analysis. RESULTS: Mean age was 58.6 years and average follow-up was 38 months...
September 27, 2016: British Journal of Cancer
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