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https://www.readbyqxmd.com/read/29350347/low-birth-weight-is-a-conditioning-factor-for-podocyte-alteration-and-steroid-dependance-in-children-with-nephrotic-syndrome
#1
Giovanni Conti, Dominique De Vivo, Claudia Fede, Stefania Arasi, Angela Alibrandi, Roberto Chimenz, Domenico Santoro
BACKGROUND: Low birth weight (LBW) is associated with reduced nephron endowment. Clinical-pathologic features of post adaptive focal segmental glomerulosclerosis (FSGS) have been observed in subjects with prematurity and very LBW. METHODS: We aimed to investigate the correlation between LBW and outcome in a cohort of 89 children with idiopathic nephrotic syndrome (NS) (2-12 years-old at onset, followed for > 3 years), of whom 21 with LBW (birth weight < 10th percentile for gestational age, gender, ethnicity, and maternal parity or birth weight < 2500 g)...
January 19, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29349743/chemically-and-size-resolved-particulate-matter-dry-deposition-on-stone-and-surrogate-surfaces-inside-and-outside-the-low-emission-zone-of-milan-application-of-a-newly-developed-deposition-box
#2
Luca Ferrero, Marco Casati, Lara Nobili, Luca D'Angelo, Grazia Rovelli, Giorgia Sangiorgi, Cristiana Rizzi, Maria Grazia Perrone, Antonio Sansonetti, Claudia Conti, Ezio Bolzacchini, Elena Bernardi, Ivano Vassura
The collection of atmospheric particles on not-filtering substrates via dry deposition, and the subsequent study of the particle-induced material decay, is trivial due to the high number of variables simultaneously acting on the investigated surface. This work reports seasonally resolved data of chemical composition and size distribution of particulate matter deposed on stone and surrogate surfaces obtained using a new method, especially developed at this purpose. A "Deposition Box" was designed allowing the particulate matter dry deposition to occur selectively removing, at the same time, variables that can mask the effect of airborne particles on material decay...
January 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29345589/neonatal-systemic-thrombosis-an-updated-overview
#3
Salvatore Santo Signorelli, Gea Oliveri Conti, Angelo Claudio Molinari, Martino Ruggieri, Alfina Grasso, Margherita Ferrantea
Thromboembolic disease is a complex disorder with a multifactorial aetiology and a severe outcome. In newborns and children it may be missed or diagnosed late, thus worsening the prognosis. The neonatal disease is different from the disorder affecting older children and adults. However, scant epidemiological data and few randomised clinical trials regarding paediatric patients are available, and treatment recommendations are largely based on adult guidelines. Younger patients then have several decades over which they will suffer from the complications of thrombosis and risk of a new thrombotic episode...
January 16, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29337228/monitoring-the-prevalence-of-genetically-modified-gm-maize-in-iran-food-products
#4
Motahreh Sadat Hosseini, Gilda Eslami, Bahador Hajimohammadi, Hossein Fallahzadeh, Zahra Derakhshan, Gea Oliveri Conti, Margherita Ferrante
Maize, the second most important genetically modified (GM) crop, and an ingredient in many foodstuffs worldwide. Regulations for both the labeling and the traceability of GMOs in feed chains are coming into force worldwide. To provide consumer's information, labelling for food products containing more than 0.9% of GM material is demanded by the actual EU legislation. Analysis of foods is then essential to detect and quantify GM maize material and verify the compliance with labelling information. For this purpose, reliable and accurate detection methods are a necessity...
January 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29334270/secukinumab-in-multi-failure-psoriatic-patients-the-last-hope
#5
M Magnano, C Loi, A Patrizi, P Sgubbi, R Balestri, G Rech, L Tasin, C R Girardelli, A Conti, G Odorici, A Campanati, A M Offidani, F Bardazzi
Psoriasis is a multi-systemic chronic inflammatory disease that affects about 1.5-3% of the general population, of which almost 20% suffer from a moderate-severe form. Those patients can be treated with a systemic agent, and, in case of scarce response or contraindications, they may require a biologic therapy, such as tumor necrosis factor or interleukin-12/23 inhibitors. When also those agents fail, clinicians face a true therapeutic challenge. We report a case series of multi-failure 16 patients, successfully treated with secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, recently approved for the treatment of plaque psoriasis, psoriatic arthritis and ankylosing spondylitis...
January 15, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29330839/peripheral-blood-brain-derived-neurotrophic-factor-as-a-biomarker-of-alzheimer-s-disease-are-there-methodological-biases
#6
REVIEW
Marta Balietti, Cinzia Giuli, Fiorenzo Conti
Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) levels and signaling may be involved in the etiopathogenesis of Alzheimer's disease (AD) has suggested that its blood levels could be used as a biomarker of the disease. However, higher, lower, or unchanged circulating BDNF levels have all been described in AD patients compared to healthy controls. Although the reasons for such different findings are unclear, methodological issues are likely to be involved. The heterogeneity of participant recruitment criteria and the lack of control of variables that influence circulating BDNF levels regardless of dementia (depressive symptoms, medications, lifestyle, lack of overlap between serum and plasma, and experimental aspects) are likely to bias result and prevent study comparability...
January 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29329209/gentamicin-sulfate-peg-plga-plga-h-nanoparticles-screening-design-and-antimicrobial-effect-evaluation-toward-clinic-bacterial-isolates
#7
Rossella Dorati, Antonella DeTrizio, Melissa Spalla, Roberta Migliavacca, Laura Pagani, Silvia Pisani, Enrica Chiesa, Bice Conti, Tiziana Modena, Ida Genta
Nanotechnology is a promising approach both for restoring or enhancing activity of old and conventional antimicrobial agents and for treating intracellular infections by providing intracellular targeting and sustained release of drug inside infected cells. The present paper introduces a formulation study of gentamicin loaded biodegradable nanoparticles (Nps). Solid-oil-in water technique was studied for gentamicin sulfate nanoencapsulation using uncapped Polylactide-co-glycolide (PLGA-H) and Polylactide-co-glycolide-co-Polyethylenglycol (PLGA-PEG) blends...
January 12, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29326020/cardiac-rupture-in-a-young-male-cocaine-user
#8
Adelaide Conti, Anna Paini, Chiara Rossetti, Marzia Bernini, Maria Lorenza Muiesan, Massimo Salvetti
No abstract text is available yet for this article.
January 8, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29325429/a-novel-method-for-re-positioning-suboptimally-preoperatively-placed-nephrostomy-tubes-for-pcnl-without-renal-re-puncture
#9
Yazeed Barghouthy, Vasileios Kourmpetis, Snir Dekalo, Yuval Bar-Yosef, Simon Conti, Alexander Greenstein, Mario Sofer
OBJECTIVE: Nephrostomy tubes (NT) inserted in emergency settings by interventional radiologists are frequently unsuitable for subsequent percutaneous nephrolithotomy (PCNL). We report a novel method of adjusting these NTs to be used as PCNL tracts and avoid renal re-puncture. PATIENTS AND METHODS: A retrospective search of 981 consecutive PCNLs performed in our institution between 2002-2017 identified all patients with preoperatively inserted NTs. The NTs unsuitable for PCNL were adjusted by a novel approach in which a 5-mm incision was made at the ideal puncture location (IPL) as indicated under fluoroscopic guidance...
January 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29323197/outcomes-of-ureteroscopy-miniaturization-on-tissue-damage-and-tissue-hypoxia-in-a-pig-model
#10
Juan P Caballero-Romeu, Juan A Galán-Llopis, Federico Soria, Esther Morcillo-Martín, Pablo Caballero-Pérez, Julia E De La Cruz-Conty, Jesús Romero-Maroto
Miniaturization of ureteroscopy materials is intended to decrease tissue damage. However, tissue hypoxia and the gross and microscopic effects on tissue have not been adequately assessed. We compared the gross and microscopic effects of micro-ureteroscopy (m-URS) and conventional ureteroscopy (URS) on the urinary tract. We employed 14 pigs of the Large White race. URS was performed in one of the ureters with an 8/9.8 F ureteroscope, while a 4.85 F m-URS sheath was used in the contralateral ureter. Gross assessment of ureteral wall damage and ureteral orifice damage was performed...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318390/dual-training-as-clinician-scientist-in-child-and-adolescent-psychiatry-are-we-there-yet
#11
EDITORIAL
Alexis Revet, Johannes Hebebrand, Sampada Bhide, João Caseiro, Eugenia Conti, Marike Deutz, Andra Isac, Athanasios Kanellopoulos, Tuğba Kalyoncu, Katri Maasalo, Silvana Markovska-Simoska, Marija Mitkovic-Voncina, Silvia Molteni, Mariela Mosheva, Susanne Mudra, Julia Philipp, Cecil Prins-Aardema, Marina Romero Gonzalez, Antonín Šebela, Jochen Seitz, Lise Eilin Stene, Nikolina Vrljičak Davidović, Ida Wessing, Paul Klauser
No abstract text is available yet for this article.
January 9, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29317412/sociodemographic-factors-level-of-physical-activity-and-health-related-quality-of-life-in-adults-from-the-north-east-of-s%C3%A3-o-paulo-brazil-a-cross-sectional-population-study
#12
Nicoly Machado Maciel, Marta Helena Souza De Conti, Sandra Fiorelli Almeida Penteado Simeão, Caio Vitor Dos Santos Genebra, José Eduardo Corrente, Alberto De Vitta
OBJECTIVE: To verify the association among sociodemographic variables, physical activity level and health-related quality of life in adults aged 20 years and over. METHODS: Population-based study, with household sample by clusters. The dependent variables were the PCS and MCS scores of the instrument 36-Item Short-Form Health Survey (SF-36), the independent variables were gathered in sociodemographic characteristics and the level of physical activity. Absolute and relative frequency distributions were used for categorical variables and bivariate analysis, using Student's t-test and ANOVA and multivariate using non-conditional logistic regression...
January 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316931/nutritional-adequacy-of-a-novel-human-milk-fortifier-from-donkey-milk-in-feeding-preterm-infants-study-protocol-of-a-randomized-controlled-clinical-trial
#13
Alessandra Coscia, Enrico Bertino, Paola Tonetto, Chiara Peila, Francesco Cresi, Sertac Arslanoglu, Guido E Moro, Elena Spada, Silvano Milani, Marzia Giribaldi, Sara Antoniazzi, Amedeo Conti, Laura Cavallarin
BACKGROUND: Fortification of human milk is a standard practice for feeding very low birth weight infants. However, preterm infants often still experience suboptimal growth and feeding intolerance. New fortification strategies and different commercially available fortifiers have been developed. Commercially available fortifiers are constituted by a blend of ingredients from different sources, including plant oils and bovine milk proteins, thus presenting remarkable differences in the quality of macronutrients with respect to human milk...
January 9, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29311610/interneuron-specific-signaling-evokes-distinctive-somatostatin-mediated-responses-in-adult-cortical-astrocytes
#14
Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta, Linda Maria Requie, Iacopo Marcon, Arianna Pugliese, Cécile Viollet, Bernhard Bettler, Tommaso Fellin, Fiorenzo Conti, Giorgio Carmignoto
The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust GABAB receptor-mediated Ca2+ elevations, respectively...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29311405/worsening-of-serum-lipid-profile-after-direct-acting-antiviral-treatment
#15
Stefano Gitto, Arrigo F G Cicero, Elisabetta Loggi, Marina Giovannini, Fabio Conti, Elena Grandini, Valeria Guarneri, Alessandra Scuteri, Giovanni Vitale, Carmela Cursaro, Claudio Borghi, Pietro Andreone
INTRODUCTION: Host lipid metabolism influences viral replication and lifecycle of hepatitis C virus. Our aim was to evaluate changes in glucose and lipid metabolism of patients with chronic hepatitis C after therapy with direct acting antivirals (DAA). MATERIAL AND METHODS: We considered patients consecutively treated between January and November 2015 recording clinical data at baseline and week 24 of follow-up. Frozen serum samples were used for apolipoprotein A1 (apoA1), apolipoprotein B (apoB) and lipoprotein (a) [Lp(a)]...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310931/extracorporeal-membrane-oxygenation-for-recovery-then-elective-surgical-repair
#16
EDITORIAL
Vincent R Conti
No abstract text is available yet for this article.
December 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29305275/thyroid-autoantibodies-and-the-clinical-presentation-of-moyamoya-disease-a-prospective-study
#17
Luigi A Lanterna, Silvia Galliani, Rosalia Zangari, Luciano Conti, Carlo Brembilla, Paolo Gritti, Maria Luisa Colleoni, Claudio Bernucci
BACKGROUND: Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. METHODS: This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM)...
January 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29303331/multicomponent-electron-hole-superfluidity-and-the-bcs-bec-crossover-in-double-bilayer-graphene
#18
S Conti, A Perali, F M Peeters, D Neilson
Superfluidity in coupled electron-hole sheets of bilayer graphene is predicted here to be multicomponent because of the conduction and valence bands. We investigate the superfluid crossover properties as functions of the tunable carrier densities and the tunable energy band gap E_{g}. For small band gaps there is a significant boost in the two superfluid gaps, but the interaction-driven excitations from the valence to the conduction band can weaken the superfluidity, even blocking the system from entering the Bose-Einstein condensate (BEC) regime at low densities...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29299219/comparison-of-elbow-flexor-isokinetic-peak-torque-and-fatigue-index-between-men-and-women-of-different-training-level
#19
Paulo Gentil, Mario Hebling Campos, Saulo Soares, Gustavo De Conti Teixeira Costa, Antonio Paoli, Antonino Bianco, Martim Bottaro
The purpose of the study was to compare elbow flexion peak torque (PT) and fatigue index (FI) during isokinetic concentric contractions in men and women with different training levels. Sixty-eight young men and women were divided into four groups: resistance trained men (RTM), non-resistance trained men (NRTM), resistance trained women (RTW) and non- resistance trained women (NRTW). Participants performed two tests on an isokinetic dynamometer, one to evaluate PT and one to evaluate FI. Significant interactions were found for sex and resistance training status with both PT and FI...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29297565/prognostic-role-of-xtp1-depdc1b-and-sdp35-depdc1a-in-high-grade-soft-tissue-sarcomas
#20
Serena Pollino, Maria Serena Benassi, Laura Pazzaglia, Amalia Conti, Nicoletta Bertani, Alberto Righi, Martina Piccinni-Leopardi, Piero Picci, Roberto Perris
BACKGROUND: The outcome of patients with metastatic soft tissue sarcoma (STS) remains unfavourable and new therapeutic strategies are needed. The aim of this study was to determine the role of RhoGAP, XTP1/DEPDC1B and SDP35/DEPDC1A, as possible prognostic markers, to be used to identify candidate patients for more effective and personalized therapies. MATERIALS-METHODS: SDP35/DEPDC1A and XTP1/DEPDC1B transcriptional levels were evaluated by Real-Time PCR in 86 primary STS and 22 paired lung metastasis...
January 3, 2018: Histology and Histopathology
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