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https://www.readbyqxmd.com/read/29792981/probabilistic-non-carcinogenic-and-carcinogenic-risk-assessments-monte-carlo-simulation-method-of-the-measured-acrylamide-content-in-tah-dig-using-quechers-extraction-and-uhplc-ms-ms
#1
Parvin Eslami Shahrbabki, Bahador Hajimohammadi, Shahram Shoeibi, Mehdi Elmi, Arash Yousefzadeh, Gea Oliveri Conti, Margherita Ferrante, Maryam Amirahmadi, Yadolah Fakhri, Amin Mousavi Khaneghah
A modified "Quick, Easy, Cheap, Effective, Rugged, and Safe" QuEChERS in combination with Ultra-High Performance Liquid Chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was optimized for the determination of acrylamide content in different types of tah-dig (rice, bread, and potato). Also, the non-carcinogenic and carcinogenic risks (target hazard quotient (THQ) and incremental lifetime cancer risk (ILCR)) due to ingestion of acrylamide via tah-dig in the adults and children were assessed by Monte Carlo simulation (MCS) method...
May 21, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29791572/is-lipid-accumulation-product-associated-with-an-atherogenic-lipoprotein-profile-in-brazilian-subjects
#2
Flavia De Conti Cartolano, Caroline Pappiani, Maria Camila Prupper de Freitas, Antonio M Figueiredo Neto, Antônio Augusto Ferreira Carioca, Nágila Raquel Teixeira Damasceno
BACKGROUND: Lipid accumulation product (LAP), a simple and low-cost tool, is a novel biomarker of central lipid accumulation and represents a potential surrogate marker for atherogenic lipoprotein profile. However, its association with lipoprotein subfractions has not been described in the literature. OBJECTIVE: To determine whether LAP index could be used as a marker of low- and high-density lipoprotein (LDL and HDL) size in Brazilian individuals. METHODS: This cross-sectional study included patients (n = 351) of both sexes and age between 30-74 years...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29790979/petrosal-meningiomas-factors-affecting-outcome-and-the-role-of-intraoperative-multimodal-assistance-to-microsurgery
#3
Francesco Tomasello, Filippo Flavio Angileri, Alfredo Conti, Antonino Scibilia, Salvatore Cardali, Domenico La Torre, Antonino Germanò
BACKGROUND: Petrous meningiomas (PMs) represent a subset of posterior fossa tumors accounting for ∼8% of all intracranial meningiomas. Surgical treatment of PMs is challenging because of their relationships with vital neurovascular structures of the cerebellopontine angle. OBJECTIVE: To investigate independent pre- and intraoperative predictors of PM surgery outcome. METHODS: We reviewed the surgical and outcome data of patients who underwent microsurgical resection of PMs from 1997 to 2016...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790083/point-quantification-elastography-in-the-evaluation-of-liver-elasticity-in-healthy-volunteers-a-reliability-study-based-on-operator-expertise
#4
Cristina Felicani, Chiara De Molo, Horia Stefanescu, Fabio Conti, Elena Mazzotta, Veronica Gabusi, Elena Nardi, Antonio Maria Morselli-Labate, Pietro Andreone, Carla Serra
PURPOSE: The assessment of liver fibrosis is essential in the management of patients with chronic liver diseases. Liver biopsy is considered the gold standard procedure for this purpose, though the recent development of new elastosonographic techniques to measure liver stiffness (LS) noninvasively is promising. Point quantification elastography (PQE) showed good results but less is known about the level of skill needed to obtain reliable results. The aim of the study was to evaluate the reproducibility of PQE in assessing LS in healthy subjects comparing three operators with different expertise...
May 22, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29789334/x-ray-exposure-in-cardiac-electrophysiology-a-retrospective-analysis-in-8150-patients-over-7-years-of-activity-in-a-modern-large-volume-laboratory
#5
Michela Casella, Antonio Dello Russo, Eleonora Russo, Valentina Catto, Francesca Pizzamiglio, Martina Zucchetti, Benedetta Majocchi, Stefania Riva, Giulia Vettor, Maria Antonietta Dessanai, Gaetano Fassini, Massimo Moltrasio, Fabrizio Tundo, Carlo Vignati, Sergio Conti, Alice Bonomi, Corrado Carbucicchio, Luigi Di Biase, Andrea Natale, Claudio Tondo
BACKGROUND: Only a few studies have systematically evaluated fluoroscopy data of electrophysiological and device implantation procedures. Aims of this study were to quantify ionizing radiation exposure for electrophysiological/device implantation procedures in a large series of patients and to analyze the x-ray exposure trend over years and radiation exposure in patients undergoing atrial fibrillation ablation considering different technical aspects. METHODS AND RESULTS: We performed a retrospective analysis of all electrophysiological/device implantation procedures performed during the past 7 years in a modern, large-volume laboratory...
May 22, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29782883/a-new-outlook-on-cholinergic-interneurons-in-parkinson-s-disease-and-l-dopa-induced-dyskinesia
#6
REVIEW
Melissa M Conti, Nicole Chambers, Christopher Bishop
Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dyskinetic state. ChIs integrate numerous neurotransmitter signals using intrinsic glutamate, serotonin, and DA receptors and convey the appropriate transmission onto nearby muscarinic and nicotinic ACh receptors to produce movement...
May 18, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29779436/early-lupus-project-one-year-follow-up-of-an-italian-cohort-of-patients-with-systemic-lupus-erythematosus-of-recent-onset
#7
G D Sebastiani, I Prevete, A Iuliano, M Piga, F Iannone, L Coladonato, M Govoni, A Bortoluzzi, M Mosca, C Tani, A Doria, L Iaccarino, A Tincani, M Fredi, F Conti, F R Spinelli, M Galeazzi, F Bellisai, A Zanetti, G Carrara, C A Scirè, A Mathieu
Objective To describe the clinical and serological features of a prospectively followed cohort of early diagnosed systemic lupus erythematosus (SLE) patients during a one-year follow-up period. Methods SLE patients with disease duration less than 12 months were consecutively enrolled in a multicentre, prospective study. At study entry and then every 6 months, a large panel of data was recorded. Results Of 260 patients enrolled, 185 had at least 12 months of follow-up; of these, 84.3% were female, 92.4% were Caucasians...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29777603/-communication-of-the-diagnosis-of-down-syndrome-mother-s-stories
#8
Teresa Vargas Aldecoa, José Luis Martin Conty, Rosa María Conty Serrano, Cristina Fernández Pérez
The article studies the way in which health professionals communicate the diagnosis of Down syndrome to parents. For that the personal stories of the mothers collected in the answers given by them to the open questions of a questionnaire on ″communication of the diagnosis″ are analyzed. The results show the mothers' dissatisfaction with the information received during the prenatal and postnatal diagnosis of Down síndrome.
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29776742/discovery-of-novel-n-hydroxy-2-arylisoindoline-4-carboxamides-as-potent-and-selective-inhibitors-of-hdac11
#9
Matthew W Martin, Jennifer Y Lee, David R Lancia, Pui Yee Ng, Bingsong Han, Jennifer R Thomason, Maureen S Lynes, C Gary Marshall, Chiara Conti, Alan Collis, Monica Alvarez Morales, Kshama Doshi, Aleksandra Rudnitskaya, Lili Yao, Xiaozhang Zheng
N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising cellular activity and pharmacokinetic properties that make it a useful tool to study the biology of HDAC11 and its potential use as a therapeutic target for oncology and inflammation indications.
May 9, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29774763/outcomes-of-reconstruction-of-the-stage-ii-adult-acquired-flatfoot-deformity-in-older-patients
#10
Matthew S Conti, Mackenzie T Jones, Oleksandr Savenkov, Jonathan T Deland, Scott J Ellis
BACKGROUND: Reconstruction of the stage II adult-acquired flatfoot deformity (AAFD) often requires the use of multiple osteotomies and soft tissue procedures that may not heal well in older patients. The purpose of our study was to determine whether patients older than 65 years with stage II AAFD had inferior clinical outcomes or an increased number of subsequent surgical procedures after flatfoot reconstruction when compared with younger patients. METHODS: One-hundred forty consecutive feet (70 right, 70 left) with stage II AAFD in 137 patients were divided into 3 groups based on age: younger than 45 years (young; n = 21), 45 to 65 years (middle-aged; n = 87), and 65 years and older (older; n = 32)...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29774711/-health-impact-of-asbestos-fibres-naturally-occurring-in-mount-pollino-area-basilicata-region-southern-italy
#11
Angelo Caputo, Marco De Santis, Valerio Manno, Gabriella Cauzillo, Biagio Maria Bruni, Lorenzo Palumbo, Susanna Conti, Pietro Comba
OBJECTIVES: to estimate the health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy). DESIGN: geographic mortality, hospitalization, and incidence study. Setting and participant s: population resident in 12 Municipalities of Mount Pollino area with naturally occurring asbestos fibres. MAIN OUTCOME MEASURES: standardized mortality ratio (SMR) and standardized hospitalization rate (SHR) for asbestos-related diseases; standardized incidence ratio (SIR) for mesotheliomas...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29769125/observational-study-of-coagulation-activation-in-early-breast-cancer-development-of-a-prognostic-model-based-on-data-from-the-real-world-setting
#12
Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D'Alessandro, Paolo Marchetti, Silverio Tomao, Giuseppe Sanguineti, Antonio Giordano, Marcello Maugeri-Saccà, Gennaro Ciliberto, Laura Conti, Patrizia Vici, Maddalena Barba
BACKGROUND: Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. METHODS: Between 2008 and 2010, two hundreds thirty-five (N: 235) patients diagnosed with stage I-IIA breast cancer were included...
May 16, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29767649/experimental-psychological-stress-on-quantitative-sensory-testing-response-in-patients-with-temporomandibular-disorders
#13
Dyna Mara Araújo Oliveira Ferreira, Yuri Martins Costa, Henrique Müller de Quevedo, Leonardo Rigoldi Bonjardim, Paulo César Rodrigues Conti
AIMS: To assess the modulatory effects of experimental psychological stress on the somatosensory evaluation of myofascial temporomandibular disorder (TMD) patients. METHODS: A total of 20 women with myofascial TMD and 20 age-matched healthy women were assessed by means of a standardized battery of quantitative sensory testing. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), mechanical pain threshold (MPT), wind-up ratio (WUR), and pressure pain threshold (PPT) were performed on the facial skin overlying the masseter muscle...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29762183/butterfly-vertebrae
#14
Curtis C Copeland, Bianca M Conti, L Yvette Fouché-Weber, Thomas Grissom
No abstract text is available yet for this article.
May 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29762117/smartphone-photography-as-a-tool-to-measure-knee-range-of-motion
#15
Megan Conti Mica, Eric R Wagner, Alexander Y Shin
The objective of this study was to validate measuring knee range of motion (ROM) from smartphone photography. Thirty-two participants (64 knees) obtained smartphone photographs of knee flexion and extension. Surgeons obtained the same photographs and goniometric measurement of ROM. ROM was measured using Adobe Photoshop. Goniometer versus digital measurements, participant versus surgeon photographs, and interobserver measurements were analyzed. The average difference in goniometer and digital photograph measurements was 5°...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29759048/evaluation-of-atg5-polymorphisms-in-italian-patients-with-systemic-lupus-erythematosus-contribution-to-disease-susceptibility-and-clinical-phenotypes
#16
C Ciccacci, C Perricone, C Alessandri, A Latini, C Politi, F Delunardo, M Pierdominici, F Conti, G Novelli, E Ortona, P Borgiani
Systemic lupus erythematosus (SLE) is a common heterogeneous autoimmune disease that is caused by the involvement both of genetic and environmental factors. There is evidence that autophagy is involved in several aspects of SLE pathogenesis. In particular, polymorphisms in the ATG5 gene have been observed to be associated with disease susceptibility. Our aim was to verify if ATG5 polymorphisms are involved in the susceptibility to disease and its clinical phenotypes in an Italian cohort of SLE patients. This study involved 315 SLE patients and 265 healthy controls...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29756909/linear-hyperfine-tuning-of-donor-spins-in-silicon-using-hydrostatic-strain
#17
J Mansir, P Conti, Z Zeng, J J Pla, P Bertet, M W Swift, C G Van de Walle, M L W Thewalt, B Sklenard, Y M Niquet, J J L Morton
We experimentally study the coupling of group V donor spins in silicon to mechanical strain, and measure strain-induced frequency shifts that are linear in strain, in contrast to the quadratic dependence predicted by the valley repopulation model (VRM), and therefore orders of magnitude greater than that predicted by the VRM for small strains |ϵ|<10^{-5}. Through both tight-binding and first principles calculations we find that these shifts arise from a linear tuning of the donor hyperfine interaction term by the hydrostatic component of strain and achieve semiquantitative agreement with the experimental values...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29753567/junctional-adhesion-molecules-jam-b-and-jam-c-promote-autoimmune-mediated-liver-fibrosis-in-mice
#18
Edith Hintermann, Monika Bayer, Clara Benedetta Conti, Sina Fuchs, Michel Fausther, Patrick S Leung, Michel Aurrand-Lions, Richard Taubert, Josef M Pfeilschifter, Mireen Friedrich-Rust, Detlef Schuppan, Jonathan A Dranoff, M Eric Gershwin, Michael P Manns, Beat A Imhof, Urs Christen
Fibrosis remains a serious health concern in patients with chronic liver disease. We recently reported that chemically induced chronic murine liver injury triggers increased expression of junctional adhesion molecules (JAMs) JAM-B and JAM-C by endothelial cells and de novo synthesis of JAM-C by hepatic stellate cells (HSCs). Here, we demonstrate that biopsies of patients suffering from primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH) display elevated levels of JAM-C on portal fibroblasts (PFs), HSCs, endothelial cells and cholangiocytes, whereas smooth muscle cells expressed JAM-C constitutively...
May 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29752142/genetic-diversity-of-theileria-equi-and-babesia-caballi-infecting-horses-of-central-southern-italy-and-preliminary-results-of-its-correlation-with-clinical-and-serological-status
#19
Giuseppe Manna, Antonella Cersini, Roberto Nardini, Leticia Elisa Bartolomé Del Pino, Valeria Antognetti, Maurizio Zini, Raffaella Conti, Raniero Lorenzetti, Vincenzo Veneziano, Gian Luca Autorino, Maria Teresa Scicluna
Babesia caballi and Theileria equi are tick-borne pathogens causing equine piroplasmosis infecting the Equidae family in which they cause significant sanitary and economic losses. Furthermore, equine piroplasmosis is included in the World Animal Health Organization (OIE) notifiable diseases list with possible movement restrictions for positive horses. Thirty-nine EDTA and whole-blood samples collected during 2013 and 2014 from symptomatic and asymptomatic horses of Central-Southern Italy were included in the present study either because of their strongly positive results in Real Time (RT) PCRs targeting the 18S rRNA gene specific for each piroplasm and/or due to their serological ELISA/18S rRNA RT-PCR discordant results...
May 4, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29752039/impact-of-fungi-on-immune-responses
#20
Pio Conti, Lucia Tettamanti, Filiberto Mastrangelo, Gianpaolo Ronconi, Ilias Frydas, Spiros K Kritas, Alessandro Caraffa, Franco Pandolfi
Spores and fungal fragments found in indoor and outdoor environments originate from opportunistic fungi and they can contribute to inflammatory responses, causing a broad range of symptoms. Papers were selected and reviewed with an emphasis on the molecular mechanisms involved in the effect of fungi on immune cells, especially mast cells (MCs). Fungi can bind to antibodies and complement them, allowing them to be recognized by cells of the innate immune system, including macrophages, dendritic cells, and MCs, which are then stimulated via Toll-like receptor signaling...
May 8, 2018: Clinical Therapeutics
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