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Elastography and radiotherapy

Cheng Wei, Magdalena Szewczyk-Bieda, Paddy Nibblok, E Brown, Stephen Lang, Ghulam Nabi
BACKGROUND: To evaluate pre-surgical quantitative transrectal shear wave elastography (SWE) in the detection and characterisation of radioresistant prostate cancer. METHODS: Twelve men with recurrent prostate cancer following external beam radiotherapy were included in a prospective protocol-driven study. All underwent MR imaging and quantitative shear wave elastographic assessment of recurrent disease prior to salvage laparoscopic radical prostatectomy procedures...
May 14, 2018: Surgical Endoscopy
Turgut Kültür, Müyesser Okumuş, Mikail İnal, Selim Yalçın
OBJECTIVES: The aim of this study was to analyze the elasticity characteristics of the brachial plexus by shear wave elastography (SWE) in patients receiving radiation therapy (RT) for breast cancer and to compare them with their contralateral brachial plexus to evaluate whether elasticity properties can be used as supporting findings for the early diagnosis of brachial plexus involvement in patients receiving RT. METHODS: A prospective analysis with electromyography and SWE was performed on 23 brachial plexuses of patients receiving RT for breast cancer and their contralateral brachial plexuses...
February 5, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Katelyn Hasse, Dylan O'Connell, Yugang Min, John Neylon, Daniel A Low, Anand Santhanam
PURPOSE: Lung diseases are commonly associated with changes in lung tissue's biomechanical properties. Functional imaging techniques, such as elastography, have shown great promise in measuring tissue's biomechanical properties, which could expand the utility and effectiveness of radiotherapy treatment planning. We present a novel methodology for characterizing a key biomechanical property, parenchymal elasticity, derived solely from 4DCT datasets. METHODS: Specifically, end-inhalation and end-exhalation breathing phases of the 4DCT datasets were deformably registered and the resulting displacement maps were considered to be ground-truth...
February 2018: Medical Physics
Xiaofeng Yang, Mylin Torres, Stephanie Kirkpatrick, Walter J Curran, Tian Liu
PURPOSE: Lymphedema, a swelling of the extremity, is a debilitating morbidity of cancer treatment. Current clinical evaluation of lymphedema is often based on medical history and physical examinations, which is subjective. In this paper, the authors report an objective, quantitative 2D strain imaging approach using a hybrid deformable registration to measure soft-tissue stiffness and assess the severity of lymphedema. METHODS: The authors have developed a new 2D strain imaging method using registration of pre- and post-compression ultrasound B-mode images, which combines the statistical intensity- and structure-based similarity measures using normalized mutual information (NMI) metric and normalized sum-of-squared-differences (NSSD), with an affine-based global and B-spline-based local transformation model...
2017: PloS One
Yan Xu, Lijing Zhu, Baorui Liu, Tong Ru, Huanhuan Wang, Jian He, Song Liu, Xiaofeng Yang, Zhengyang Zhou, Tian Liu
BACKGROUND: To investigate the feasibility of strain elastography imaging in early detecting and predicting treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for locally advanced cervical cancer. METHODS: Between January 2015 and June 2016, 47 patients with locally advanced cervical cancer were enrolled in a feasibility study approved by the institutional review board. All patients underwent CCRT and received strain elastography examinations at 4 time points: pre-therapy (baseline), 1 week and 2 weeks during, as well as immediately post CCRT...
June 19, 2017: BMC Cancer
K Hasse, J Neylon, D Low, A Santhanam
PURPOSE: The purpose of this project is to derive high precision elastography measurements from 4DCT lung scans to facilitate the implementation of elastography in a radiotherapy context. METHODS: 4DCT scans of the lungs were acquired, and breathing stages were subsequently registered to each other using an optical flow DIR algorithm. The displacement of each voxel gleaned from the registration was taken to be the ground-truth deformation. These vectors, along with the 4DCT source datasets, were used to generate a GPU-based biomechanical simulation that acted as a forward model to solve the inverse elasticity problem...
June 2016: Medical Physics
Y Feng, E H Clayton, R J Okamoto, J Engelbach, P V Bayly, J R Garbow
An accurate and noninvasive method for assessing treatment response following radiotherapy is needed for both treatment monitoring and planning. Measurement of solid tumor volume alone is not sufficient for reliable early detection of therapeutic response, since changes in physiological and/or biomechanical properties can precede tumor volume change following therapy. In this study, we use magnetic resonance elastography to evaluate the treatment effect after radiotherapy in a murine brain tumor model. Shear modulus was calculated and compared between the delineated tumor region of interest (ROI) and its contralateral, mirrored counterpart...
August 21, 2016: Physics in Medicine and Biology
R Kumar, M Griffin, G Adigbli, N Kalavrezos, P E M Butler
BACKGROUND: Radiation-induced fibrosis (RIF) is a late complication of radiotherapy that results in progressive functional and cosmetic impairment. Autologous fat has emerged as an option for soft tissue reconstruction. There are also sporadic reports suggesting regression of fibrosis following regional lipotransfer. This systematic review aimed to identify cellular mechanisms driving RIF, and the potential role of lipotransfer in attenuating these processes. METHODS: PubMed, OVID and Google Scholar databases were searched to identify all original articles regarding lipotransfer for RIF...
July 2016: British Journal of Surgery
Mark Ruschin, Sean R H Davidson, William Phounsy, Tae Sun Yoo, Lee Chin, Jean-Philippe Pignol, Ananth Ravi, Claire McCann
PURPOSE: To develop a multipurpose gel-based breast phantom consisting of a simulated tumor with realistic imaging properties in CT, ultrasound and MRI, or a postsurgical cavity on CT. Applications for the phantom include: deformable image registration (DIR) quality assurance (QA), autosegmentation validation, and localization testing and training for minimally invasive image-guided procedures such as those involving catheter or needle insertion. METHODS: A thermoplastic mask of a typical breast patient lying supine was generated and then filled to make an array of phantoms...
May 2016: Medical Physics
Tuathan O'Shea, Jeffrey Bamber, Davide Fontanarosa, Skadi van der Meer, Frank Verhaegen, Emma Harris
Imaging has become an essential tool in modern radiotherapy (RT), being used to plan dose delivery prior to treatment and verify target position before and during treatment. Ultrasound (US) imaging is cost-effective in providing excellent contrast at high resolution for depicting soft tissue targets apart from those shielded by the lungs or cranium. As a result, it is increasingly used in RT setup verification for the measurement of inter-fraction motion, the subject of Part I of this review (Fontanarosa et al 2015 Phys...
April 21, 2016: Physics in Medicine and Biology
Katelyn Hasse, John Neylon, Ke Sheng, Anand P Santhanam
PURPOSE: Breast elastography is a critical tool for improving the targeted radiotherapy treatment of breast tumors. Current breast radiotherapy imaging protocols only involve prone and supine CT scans. There is a lack of knowledge on the quantitative accuracy with which breast elasticity can be systematically measured using only prone and supine CT datasets. The purpose of this paper is to describe a quantitative elasticity estimation technique for breast anatomy using only these supine/prone patient postures...
March 2016: Medical Physics
Elena Tatiana Cârțână, Dan Ionuț Gheonea, Adrian Săftoiu
The development of endoscopic ultrasound (EUS) has had a significant impact for patients with digestive diseases, enabling enhanced diagnostic and therapeutic procedures, with most of the available evidence focusing on upper gastrointestinal (GI) and pancreatico-biliary diseases. For the lower GI tract the main application of EUS has been in staging rectal cancer, as a complementary technique to other cross-sectional imaging methods. EUS can provide highly accurate in-depth assessments of tumour infiltration, performing best in the diagnosis of early rectal tumours...
February 7, 2016: World Journal of Gastroenterology: WJG
Iulia Badea, Attila Tamas-Szora, Ioana Chiorean, Maria Crisan, Elisabeta Ciuleanu, Grigore Baciut, Mindra Badea
AIM: We aim to define the values of the shear wave velocity (SWV) in the normal parotid glands (PG) and to identify the modifications of tissue stiffness in patients with irradiated nasopharyngeal carcinoma. MATERIAL AND METHODS: Sixty normal parotid glands pertaining to 30 healthy volunteers and 40 pathological parotid glands pertaining to 20 patients who had had underwent radiation therapy for nasopharyngeal carcinoma were included in this study. The patients underwent a B mode ultrasonography examination and the volume of the parotid gland was determined...
September 2015: Medical Ultrasonography
Christina An Gkali, Athanasios N Chalazonitis, Eleni Feida, Aris Giannos, Maria Sotiropoulou, Constantine Dimitrakakis, Dimitrios Loutradis
Lymphomas constitute approximately 0.15% of malignant mammary neoplasms. Less than 0.5% of all malignant lymphomas involve the breast primarily. Primary non-Hodgkin breast lymphoma is usually right sided. The combined therapy approach, with chemotherapy and radiotherapy, is the most successful treatment. Mastectomy offers no benefit in the treatment of primary non-Hodgkin breast lymphoma. To the author's knowledge, this is the first published case of primary non-Hodgkin breast lymphoma reported with conventional ultrasonography, elastography (both freehand and acoustic radiation force impulse imaging), digital mammography, contrast-enhanced digital mammography, and pathology findings...
December 2015: Ultrasound Quarterly
M Pillon, N S Carucci, C Mainardi, E Carraro, M Zuliani, L Chemello, E Calore, M Tumino, S Varotto, T Toffolutti, R Destro, M V Gazzola, R Alaggio, G Basso, C Messina
Hepatic focal nodular hyperplasia (FNH) is a nonmalignant condition rarely affecting children previously treated for cancer, especially those who received hematopoietic SCT (HSCT). Some aspects of its pathogenesis still remain unclear and a strong association with specific risk factors has not yet been identified. We report here a single institution's case series of 17 patients who underwent HSCT and were diagnosed with FNH, analyzing retrospectively their clinical features and the radiological appearance of their hepatic lesions...
March 2015: Bone Marrow Transplantation
Juana Gonzalo-Marin, Juan Jose Vila, Manuel Perez-Miranda
Endoscopic ultrasonography (EUS) with or without fine needle aspiration has become the main technique for evaluating pancreatobiliary disorders and has proved to have a higher diagnostic yield than positron emission tomography, computed tomography (CT) and transabdominal ultrasound for recognising early pancreatic tumors. As a diagnostic modality for pancreatic cancer, EUS has proved rates higher than 90%, especially for lesions less than 2-3 cm in size in which it reaches a sensitivity rate of 99% vs 55% for CT...
September 15, 2014: World Journal of Gastrointestinal Oncology
Jarosław Kałużny, Tomasz Kopeć, Ewelina Szczepanek-Parulska, Adam Stangierski, Edyta Gurgul, Marek Ruchała, Piotr Milecki, Małgorzata Wierzbicka
The aim of the study was to assess salivary gland parenchyma by means of sonoelastography in patients irradiated for head and neck squamous cell carcinoma (HNSCC). The studied group consisted of 52 patients after radiotherapy (RT) and 54 healthy volunteers. All of the former were treated for advanced larynx (40), oropharynx (9), or maxilla (3) squamous cancers and suffered from chronic dryness. Ultrasonography (US) and elastography (ES) were performed, as well as an assessment of the amount of saliva and Common Terminology Criteria for Adverse Events (CTCAE) scale...
2014: BioMed Research International
J E R Waage, S P Bach, F Pfeffer, S Leh, R F Havre, S Ødegaard, G Baatrup
AIM: Strain elastography is a novel approach to rectal tumour evaluation. The primary aim of this study was to correlate elastography to pT stages of rectal tumours and to assess the ability of the method to differentiate rectal adenomas (pT0) from early rectal cancer (pT1-2). Secondary aims were to compare elastography with endorectal ultrasonography (ERUS) and to propose a combined strain elastography and ERUS staging algorithm. METHOD: In all, 120 consecutive patients with a suspected rectal tumour were examined in this staging study...
January 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
K H Liu, K Bhatia, W Chu, L T He, S F Leung, A T Ahuja
PURPOSE: Shear wave elastography (SWE) is a new technique which provides quantitative assessment of soft tissue stiffness. The aim of this study was to assess the reliability of SWE stiffness measurements and its usefulness in evaluating post-irradiation neck fibrosis. MATERIALS AND METHODS: 50 subjects (25 patients with previous radiotherapy to the neck and 25 sex and age-matched controls) were recruited for comparison of SWE stiffness measurements (Aixplorer, Supersonic Imagine)...
August 2015: Ultraschall in der Medizin
Joyce Wilbers, Arnoud C Kappelle, Roy Pc Kessels, Stefan Ca Steens, Frederick Ja Meijer, Johannes H Kaanders, Roy Am Haast, Laura E Versteeg, Anil M Tuladhar, Chris L de Korte, Hendrik Hg Hansen, Frank J Hoebers, Willem Boogerd, Erik D van Werkhoven, Marlies E Nowee, Guus Hart, Harry Bartelink, Lucille D Dorresteijn, Ewoud J van Dijk
BACKGROUND: Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and motor functioning. Better insight into the underlying pathofysiology of radiotherapy induced carotid artery vasculopathy is needed for prognostic purposes and to develop preventive strategies...
2014: BMC Neurology
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