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urinary tracts infection

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https://www.readbyqxmd.com/read/29168466/new-delhi-metallo-%C3%AE-lactamase-type-carbapenemases-producing-escherichia-coli-isolates-from-hospitalized-patients-a-pilot-study
#1
Shyam Sunder Grover, Ananya Doda, Nupur Gupta, Inderjeet Gandhoke, Jyoti Batra, Charoo Hans, Shashi Khare
BACKGROUND & OBJECTIVES: Resistances to carbapenem group of antimicrobials among Escherichia coli due to production of carbapenemases, especially the New Delhi metallo-β-lactamase (NDM) types, pose serious challenges in the treatment of infections in healthcare settings. This study was undertaken to detect NDM producing E. coli isolates from hospitalized patients with urinary tract infection (UTI). METHODS: A total of 30 non-repetitive isolates of E. coli from hospitalized patients with clinical suspicion of UTI were subjected to antimicrobial susceptibility testing...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168442/seasonality-of-urinary-tract-infections-in-the-united-kingdom-in-different-age-groups-longitudinal-analysis-of-the-health-improvement-network-thin
#2
A Rosello, K B Pouwels, M Domenech DE Cellès, E VAN Kleef, A C Hayward, S Hopkins, J V Robotham, T Smieszek, L Opatowski, S R Deeny
Evidence regarding the seasonality of urinary tract infection (UTI) consultations in primary care is conflicting and methodologically poor. To our knowledge, this is the first study to determine whether this seasonality exists in the UK, identify the peak months and describe seasonality by age. The monthly number of UTI consultations (N = 992 803) and nitrofurantoin and trimethoprim prescriptions (N = 1 719 416) during 2008-2015 was extracted from The Health Improvement Network (THIN), a large nationally representative UK dataset of electronic patient records...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29165707/inflammation-dynamics-after-praziquantel-treatment-of-schistosoma-haematobium-reflected-by-urinary-eosinophil-cationic-protein
#3
Chalotte Willemann Stecher, Hassan K M Fofana, Henry Madsen, Shona Wilson, Adama D Keita, Aly Landouré, Mamadou S Traoré, Birgitte J Vennervald, Claus M Reimert, Moussa Sacko
Background: This cohort study assessed urinary eosinophil cationic protein (ECP) as an indicator for urinary tract morbidity and inflammation indication related to single-dose or dual-dose praziquantel (PZQ) treatment. Methods: Urinary ECP was measured at baseline, 24 h and 9 weeks after treatment (baseline 305, follow-up 204 participants, ages 2-40 years). Results: ECP was significantly associated with the intensity of infection at baseline (p<0...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165097/a-predictive-model-of-the-prevalence-of-delirium-in-elderly-subjects-admitted-to-nursing-homes
#4
Pilar Perez-Ros, Francisco Miguel Martinez-Arnau, Susana Baixauli-Alacreu, Jose Fermin Garcia-Gollarte, Francisco Tarazona-Santabalbina
INTRODUCTION: Delirium is common in geriatric patients admitted to nursing homes, with an incidence of 22-79% among long-term residents. AIM: To establish a predictive model of the risk of delirium episodes in a sample of elderly people living in nursing homes. MATERIAL AND METHODS: A retrospective, cross-sectional case-control study covering a period of 12 consecutive months (April 2014 - March 2015) was carried out. The included cases had suffered at least one episode of delirium during the study period...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29164173/factors-related-to-the-severity-of-delirium-in-the-elderly-patients-with-infection
#5
R A Tuty Kuswardhani, Yosef Samon Sugi
Objective: Delirium is a common neuropsychiatric syndrome in the elderly characterized by concurrent impairments in cognition and behavior. Infection is one of the most important risk factors for delirium. The objective of this study is to elaborate the factors related to the severity of delirium in the elderly patients with infection. Method: An observational study on the relationship of several clinical parameters and the severity of delirium in elderly patients (more than 60 years) with infection was conducted at Geriatric Inpatient Ward, Sanglah Hospital...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29164118/infections-caused-by-antimicrobial-drug-resistant-saprophytic-gram-negative-bacteria-in-the-environment
#6
Eva Raphael, Lee W Riley
Background: Drug-resistance genes found in human bacterial pathogens are increasingly recognized in saprophytic Gram-negative bacteria (GNB) from environmental sources. The clinical implication of such environmental GNBs is unknown. Objectives: We conducted a systematic review to determine how often such saprophytic GNBs cause human infections. Methods: We queried PubMed for articles published in English, Spanish, and French between January 2006 and July 2014 for 20 common environmental saprophytic GNB species, using search terms "infections," "human infections," "hospital infection...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29162286/medical-management-of-a-subretinal-klebsiella-pneumoniae-abscess-with-excellent-visual-outcome-without-performing-vitrectomy
#7
A Martel, B Butet, J C Ramel, D Martiano, S Baillif
OBJECTIVE: To report the case of a Klebsiella pneumoniae endogenous endophthalmitis (KPEE) of hepatic and urinary origin that was successfully treated with systemic antibiotherapy and 13 intravitreal antibiotics injections without performing a vitrectomy. PATIENT AND METHOD: Case report of a 60-year-old man with a subretinal abscess in the left eye that developed 3 days after initial presentation for K. pneumoniae bacteremia, liver abscess and urinary tract infection...
November 18, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29161406/evaluation-of-the-bacterioscan-216dx-for-standalone-preculture-screen-of-preserved-urine-specimens-in-a-clinical-setting
#8
Amity L Roberts, Upasana Joneja, Tatiana Villatoro, Eileen Andris, Judith A Boyle, James Bondi
Background: The BacterioScan 216Dx laser microbial growth monitoring system was evaluated as an option for preurine culture screening of preserved urine specimens at an acute care medical center. Methods: The BacterioScan 216Dx system performance characteristics and the economic impact (cost effectiveness) for the laboratory were assessed. Urinalysis performance compared to urine culture was assessed if urinalysis was ordered as part of the patient care set. Results: When compared to urine culture, the BacterioScan had an overall performance with corresponding 95% confidence intervals of 76% (68-83) sensitivity, 84% (80-87) specificity, 55% (48-63) positive predictive value, and 93% (90-95) negative predictive value for 610 randomly selected preserved urine specimens...
November 17, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29160571/sacral-neuromodulation-and-pregnancy-results-of-a-national-survey-carried-out-for-the-neuro-urology-committee-of-the-french-association-of-urology-afu
#9
Pauline Roulette, Evelyne Castel-Lacanal, Sylvain Sanson, Romain Caremel, Véronique Phé, Stéphane Bart, Franck Duchêne, Marianne De Sèze, Alexia Even, Andréa Manunta, Maria C Scheiber-Nogueira, Pascal Mouracade, Catherine-Marie Loche, Emmanuel Chartier-Kastler, Alain Ruffion, Gilles Karsenty, Xavier Gamé
AIMS: To assess the impact of sacral neuromodulation (SNM) on pregnancy and vice-versa, by identifying women who had received SNM for lower-urinary tract symptoms (LUTS) and had become pregnant. METHODS: A cross-sectional descriptive study was carried out based on responses to an on-line questionnaire sent to practitioners listed on the InterStim enCaptureTM National Registry. Questions were related to pre-pregnancy health and SNM efficacy, deactivation of the device, its impact on LUTS, childbirth, the infant, its reactivation and postpartum effectiveness...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29160004/urological-dysfunction-in-young-women-an-inheritance-of-childhood
#10
Elisabetta Costantini, Ester Illiano, Konstantinos Giannitsas, Marco Prestipino, Antonio Luigi Pastore, Antonio Carbone, Giovanni Palleschi, Raffaele Balsamo, Franca Natale, Donata Villari, Vittorio Bini, Serena Maruccia, Maria-Teresa Filocamo, Alessandro Zucchi
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood to lower urinary tract dysfunction in young adult women. SUBJECTS/PATIENTS AND METHODS: This was a multicenter, prospective, case-control study conducted from April 2013 to November 2015. The trial was registered in ClinicalTrials. gov (NCT02185287). Three-hundred women, 18 to 40 years old, participated. Cases were women attending urogynecology clinics for various lower urinary tract complaints and controls were recruited from a healthy population...
November 21, 2017: BJU International
https://www.readbyqxmd.com/read/29159694/urinary-excretion-of-ciprofloxacin-after-administration-of-extended-release-tablets-in-healthy-volunteers-swellable-drug-polyelectrolyte-matrix-versus-bilayer-tablets
#11
M L Guzmán, C B Romañuk, M F Sanchez, L C Luciani Giacobbe, L P Alarcón-Ramirez, F D Battistini, F L Alovero, A F Jimenez-Kairuz, R H Manzo, María Eugenia Olivera
This paper builds on a previous paper in which new ciprofloxacin extended-release tablets were developed based on a ciprofloxacin-based swellable drug polyelectrolyte matrix (SDPM-CIP). The matrix contains a molecular dispersion of ciprofloxacin ionically bonded to the acidic groups of carbomer, forming the polyelectrolyte-drug complex CB-CIP. This formulation showed that the release profile of the ciprofloxacin bilayer tablets currently commercialised can be achieved with a simpler strategy. Thus, since ciprofloxacin urine concentrations are associated with the clinical cure of urinary tract infections, the goal of this work was to compare the urinary excretion of SDPM-CIP tablets with those of the CIPRO XR® bilayer tablets...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29159457/ertugliflozin-in-patients-with-stage-3-chronic-kidney-disease-and-type-2-diabetes-mellitus-the-vertis-renal-randomized-study
#12
George Grunberger, Sarah Camp, Jeremy Johnson, Susan Huyck, Steven G Terra, James P Mancuso, Zhi Wei Jiang, Gregory Golm, Samuel S Engel, Brett Lauring
INTRODUCTION: Ertugliflozin is a sodium-glucose cotransporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The safety and efficacy of ertugliflozin were evaluated over 52 weeks in patients with chronic kidney disease (CKD). METHODS: In this double-blind randomized study (NCT01986855), patients with glycated hemoglobin (A1C) 7.0-10.5% and stage 3 CKD [estimated glomerular filtration rate (eGFR) ≥ 30 to < 60 mL/min/1.73 m(2)] who were undergoing treatment with standard diabetes therapy (or therapies) including insulin and/or sulfonylureas were randomized to once-daily ertugliflozin 5 mg, 15 mg, or placebo...
November 20, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29158999/recurrent-primary-suprahepatic-abscess-due-to-providencia-stuartii-a-rare-phenomenon
#13
Kyawzaw Lin, Aung Naing Lin, Sandar Linn, Madhavi Reddy, Anjali Bakshi
Gram-negative urease-producing bacilli, Providencia stuartii (P. stuartii), is reported in urinary tract infections, gastroenteritis, and bacteremia in humans but they rarely present with a hepatic abscess. We present a rare case of a recurrent suprahepatic cyst due to P. stuartii in a 45-year-old female, intravenous ( IV) heroin abuser with chronic hepatitis B and C. A 45-year-old female with 10 days status post right suprahepatic abscess drainage presented with recurrent, right, upper quadrant abdominal pain for one day...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158918/challenges-with-surveillance-of-healthcare-associated-infections-in-intensive-care-units-in-south-africa
#14
Saajida Mahomed, Ozayr Mahomed, A Willem Sturm, Stephen Knight, Prashini Moodley
Background: The incidence of healthcare-associated infections (HAIs) in the public health sector in South Africa is not known due to the lack of a surveillance system. We report on the challenges experienced in the implementation of a surveillance system for HAIs in intensive care units (ICUs). Methods: A passive, paper-based surveillance system was piloted in eight ICUs to measure the incidence of ventilator-associated pneumonia, catheter-associated urinary tract infection, and central line-associated bloodstream infection...
2017: Critical Care Research and Practice
https://www.readbyqxmd.com/read/29158245/variations-in-presentation-management-and-patient-outcomes-of-urinary-tract-infection-a-prospective-four-country-primary-care-observational-cohort-study
#15
Christopher C Butler, Nick Francis, Emma Thomas-Jones, Carl Llor, Emily Bongard, Michael Moore, Paul Little, Janine Bates, Mandy Lau, Timothy Pickles, Micaela Gal, Mandy Wootton, Nigel Kirby, David Gillespie, Kate Rumbsy, Curt Brugman, Kerenza Hood, Theo Verheij
BACKGROUND: Regional variations in the presentation of uncomplicated urinary tract infection (UTI) and pathogen sensitivity to antibiotics have been cited as reasons to justify differences in how the infections are managed, which includes the prescription of broad-spectrum antibiotics. AIM: To describe presentation and management of UTI in primary care settings, and explore the association with patient recovery, taking microbiological findings and case mix into account...
November 20, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29157781/infections-by-carbapenemase-producing-enterobacteriaceae-in-a-department-of-urology-a-new-challenge
#16
J Justo-Quintas, J Medina-Polo, J Gil-Moradillo, F Jaén-Herreros, A Lara-Isla, Á Tejido-Sánchez
OBJECTIVES: To analyse infections by carbapenemase-producing enterobacteriaceae (CPE) and describe the characteristics and potential risk factors associated with patients of a department of urology. MATERIAL AND METHODS: Observational and retrospective study. The inclusion criterion was hospitalisation in our department of Urology between August 2013 and December 2016. We analysed those patients who were positive for CPE in at least 1 culture. We reviewed their baseline characteristics, risk factors and variables such as the presence of previous urinary tract infections, subsequent readmissions, the microorganism, type of CPE, treatment, origin (hospital or community) and mortality...
November 17, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29155322/digestive-tract-colonization-by-multidrug-resistant-enterobacteriaceae-in-travellers-an-update
#17
REVIEW
Etienne Ruppé, Antoine Andremont, Laurence Armand-Lefèvre
BACKGROUND: Enterobacteriaceae have become increasingly resistant, especially due to the acquisition and spread of extended-spectrum beta-lactamases (ESBLs), which confer resistance to the majority of beta-lactams. Multi-resistant Enterobacteriaceae (MRE) were first isolated in hospitals, but now they are disseminating in the community setting, mostly in low and middle income countries. Consequently, the increasing number of international travels leads to the importation of MRE from high-prevalence to low-prevalence countries...
November 16, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29155313/a-phase-ii-multicenter-single-arm-study-to-evaluate-the-safety-and-efficacy-of-deferasirox-after-hematopoietic-stem-cell-transplantation-in-children-with-%C3%AE-thalassemia-major
#18
Mehmet Akif Yesilipek, Gulsun Karasu, Zuhre Kaya, Baris B Kuskonmaz, Vedat Uygun, Ilkiz Dag, Onur Ozudogru, Mehmet Ertem
We conducted a prospective, phase II, multicenter, single-arm study to evaluate the efficacy and safety of deferasirox in patients (aged >2 to <18 years) with β-thalassemia major (TM) who have undergone hematopoietic stem cell transplantation (HSCT) and had evidence of iron overload (serum ferritin >1000 µg/L, cardiac MRI T2* <20 ms, or liver iron concentration [LIC; by MRI R2] ≥5 mg/g). Patients received deferasirox at an initial dose of 10 mg/kg/day, with up-titration to a maximum of 20 mg/kg/day...
November 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29154987/positioning-the-instillation-of-contrast-cystography-does-it-provide-any-clinical-benefit
#19
Hakan Bahadir Haberal, Burak Çitamak, Mesut Altan, Ali Cansu Bozaci, Taner Ceylan, Hasan Serkan Doğan, Serdar Tekgül
OBJECTIVES: To outline positioning the instillation of contrast cystography (PICC)'s benefits in clinical practice. METHODS: 198 patients underwent PICC with the following indications: patients with positive preoperative conventional voiding cystourethrography (VCUG) for single ureteric side, patients with urinary tract infection, and negative VCUG for both ureteric sides. Patients with positive VCUG served as the control group. Preoperative, intraoperative, and postoperative features of all patients were compared...
November 15, 2017: Urology
https://www.readbyqxmd.com/read/29154984/five-supernumerary-renal-arteries-originating-from-the-aorta-associated-with-ureteropelvic-junction-upj-extrinsic-compression
#20
Alexander K Chow, Leslie A Deane
A 65-year-old female presented with recurrent urinary tract infections. A computed tomography of the abdomen and pelvis shows a dilated and malrotated right renal pelvis consistent with a ureteropelvic junction (UPJ) obstruction as well as multiple renal arteries arising from the aorta. A computed tomography angiography (CTA) revealed five separate renal arteries originating from the aorta with a single renal artery crossing over and obstructing the right renal pelvis. On Lasix renogram, the affected kidney contributes 45% of total renal function...
November 15, 2017: Urology
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