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Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
Lin Chen, Ying Zheng
OBJECTIVES: To build the viral integration sites map and verify the integration sites at or near the fragile site. METHODS: PCR method were applied to screen single HPV16 infected cervical carcinoma specimen and the viral integration sites in the specimens of cervical carcinomas and the cell line cells were detected by detection of integrated papillomavirus seguences by ligation-mediated PCR (DIPS-PCR). RESULTS: The integration site in cell line Siha was 13q22...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Ioannis Chatzistefanou, Joshua Lubek, Konstantinos Markou, Robert A Ord
PURPOSE: The role of perineural invasion (PNI) in the management of patients with oral squamous cell carcinoma (OSSC) is still controversial, and there is no consensus regarding the most appropriate therapeutic approach. The purpose of this study is to review the findings in the literature describing OSCC as a neurotropic malignancy, with the aim of correlating perineural invasion with treatment decisions and disease prognosis. MATERIALS AND METHODS: A literature search was conducted of references based on the MEDLINE and Cochrane Database of Systematic Reviews, with subject keywords including four main categories: perineural invasion, perineural spread, oral squamous cell cancinoma, neurotropic carcinoma...
February 24, 2017: Journal of Cranio-maxillo-facial Surgery
C M An, S X Wang, F Lyu, S Y Liu, Z G Xu, P Z Tang, S G Gao, J L Yi, Z J Li
Objective: To analyze the clinical results of gastric pull-up reconstruction following total pharyngoesophagectomy. Methods: A total of 90 patients with hypopharyngeal or cervical esophageal cancinoma who underwent gatric pull-up reconstruction after pharyngoesophagectomy between June 2006 and June 2015 were reviewed retrospectively. Clinical data were analyzed. Rates of survival, recurrence and complicates were calculated with SPSS software. Results: Of 90 patients, 8 patients had hypopharyngeal cancinoma invading cervical esophagus, 51 patients had cervical esophageal carcinoma, and 31 patients had hypophageal and esophageal multiple parimary carcinomas...
October 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Caleb Kesse Firempong, Hui Yun Zhang, Yan Wang, Jingjing Chen, Xia Cao, Wenwen Deng, Jie Zhou, Qiang Wang, Shan-Shan Tong, Jiangnan Yu, Ximing Xu
Segetoside I is a plant-derived bisdesmosidic saponin from Vaccaria segetalis (Neck) with reported anticancer activities. This development has raised an interest in the therapeutic potential of segetoside I. Here, we report the in vitro and in vivo antitumor activities of segetoside I against some selected cancer cell lines (HepG2, human hepatoma; H22, mouse hepatoma; MCF-7, breast cancer; U251, gliocoma; BGC, HGC & SGC, gastric cancinoma; Lovo-1,colon cancer). MTT bioassay analysis showed that HepG2 cells were the most sensitive to segetoside I compared with other cancer cell lines, with lower toxicity in healthy mouse embryonic fibroblast cells...
August 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Zhigang Wang, Pingfang Lu, Zhu Liang, Zhanfei Zhang, Weicheng Shi, Xiaobi Cai, Chunyuan Chen
Insulin-like growth factor 1 receptor (IGF1R) is a tyrosine kinase receptor implicated in tumourigenesis that may be an attractive target for anti-cancer treatment. In this study, the expression and clinical significance of IGF1R were investigated in serum and lung cancer tissues from small cell lung cancinoma (SCLC). We also compared the effect of IGF1R up-regulation and IGF1R inhibition on viability and apoptosis of NCI-H446 cells. We found the concentration of IGF1R in blood serum was significantly increased and positive IGF1R protein in cancer tissue was more prevalent in SCLC...
2015: Growth Factors
Mixia Ouyang, Yuan Hu, Fei Zeng
OBJECTIVE: To explore the role of apoptosis stimulating proteins of p53 2 (ASPP2) and inhibitory member of the ASPP family (iASPP) in the occurrence of cervical cancer and the relation between these two proteins and p53. METHODS: We used immunohistochemical method to detect the expression of ASPP2, iASPP, p53 in 51 patients with early cervical cancer tissue, 53 patients with cervical intraepithelial neoplasia (CIN) II-III, 48 patients with CIN I and 45 patients with normal cervical tissue...
March 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Mónica L Serrano-Arévalo, Adalberto Mosqueda-Taylor, Hugo Domínguez-Malagón, Michal Michal
The Clinco-pathological, immunohistochemical and molecular findings of four cases of Mammary Analogue Secretory Carcinoma (MASC) of salivary glands found in Mexico are described. The cases were extracted from 253 salivary gland tumors from a single institution in Mexico City. The 85 Candidates for initial selection were: low grade mucoepidermoid carcinoma (MEC) (N=70 ), Acinic cell cancinoma (AciCC) (N=14), papillary cystadenocarcinoma (N=1), and adenocarcinoma NOS (N=0). Tumors with some histological features consistent with MASC (N= 17, 6...
January 2015: Medicina Oral, Patología Oral y Cirugía Bucal
Yanping Gong, Jingqiang Zhu, Rixiang Gong
No abstract text is available yet for this article.
June 2013: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Nikos A Courcoutsakis, Christina Tatsi, Nicholas J Patronas, Chiy-Chia Richard Lee, Panos K Prassopoulos, Constantine A Stratakis
The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Spotty skin pigmentation is the major clinical manifestation of the syndrome, followed by multicentric heart myxomas, which occur at a young age and are the lethal component of the disease...
February 2013: Insights Into Imaging
Yang Zhang, Yuanyuan Ni, Hao Zhang, Yongchu Pan, Junqing Ma, Lin Wang
BACKGROUNDS: GSTM1 and GSTT1 are involved in the detoxification of carcinogens such as smoking by-products, and polymorphisms in these two genes with a result of loss of enzyme activity may increase risk of carcinogenesis. Although many epidemiological studies have investigated the association between GSTM1 or GSTT1 null genotype and head and neck squamous cell carcinoma (HNSCC), the results remain conflicting. To elucidate the overall association of GSTM1, GSTT1 and HNSCC, we included all available studies and performed this meta-analysis...
2012: PloS One
Teresa G Granda, David Cebrián, Sonia Martínez, Patricia Villanueva Anguita, Estela Casas López, Wolfgang Link, Teresa Merino, Joaquín Pastor, Beatriz G Serelde, Sandra Peregrina, Irene Palacios, Maria Isabel Albarran, Antonio Cebriá, Milagros Lorenzo, Patricia Alonso, Jesús Fominaya, Ana Rodríguez López, James R Bischoff
Inhibitors of PI3K signaling are of great therapeutic interest in oncology. The phosphoinositide-3-kinase signaling pathway is activated in a variety of solid and non-solid tumors. We have identified an imidazopyrazine derivative, ETP-46321, as a potent inhibitor of PI3Kα [Formula: see text]. The compound was 6 times less potent towards PI3Kδ and more than 200 and 60 times less potent at inhibiting PI3Kβ and PI3Kγ and did not significantly inhibit the related phosphoinositide-3-kinase-related protein kinase family kinases mTOR or DNA PK (IC(50)'s > 5 μM), or an additional 287 protein kinases that were screened...
February 2013: Investigational New Drugs
Zhu-ling Guo, Yan Gao
OBJECTIVE: To investigate the expression patterns of integrin-linked kinase (ILK) in oral squamous cell carcinoma (OSCC). METHODS: The expression of ILK in 170 OSCC cases was examined by immunohistochemistry and periodic acid-schiff histochemistry. RESULTS: ILK immunoreactivity occurred in cancer cells and(or) stroma encircling the malignant tissue. Along with the deteriorated histopathologic grade of oral cancer, there was stepwise aberration exhibiting from ILK-negative, to ILK-positive in epithelia, to ILK-positive in both epithelia and stroma, and to ILK-positive in stroma...
October 2010: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Yaying Yang, Haipeng Shi, Xiujun Li, Yongfen Yi
Maspin is a member of the serpin (serine protease inhibitor) family of protease inhibitors known to have tumor suppressor activity in diverse human cancers. However, maspin gene function and the molecular aspects in gastric carcinoma remain largely unclear. To investigate the effects of maspin on invasion of gastric carcinoma SGC7901 cell line and the underlying molecular mechanism involved in this process, we cloned short hairpin oligoes (shRNA) targeting maspin into plasmid pGenesil-1.1 eukaryotic expression vector and then transfected the recombinant plasmid pGenesil-maspin into gastric carcinoma SGC7901 cells using Lipofectamine 2000...
January 2011: Oncology Reports
Lanqin Cao, Xin Li, Xinguo Li, Yi Zhang
OBJECTIVE: To investigate the effect of neoadjuvant chemotherapy on cervical carcinoma and its association with clinical data. METHODS: A total of 97 patients with stage Ib2 approximately IIIa of cervical cancinoma were treated with neoadjuvant chemotherapy. The effect of chemotherapy, factors associated with outcome of chemotherapy, and histology were analyzed. RESULTS: Effective rate of chemotherapy was 86.6% which was associated with clinical stage and histology...
June 2009: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Tung-Ying Lu, Cheng-Fu Kao, Chin-Tarng Lin, Dah-Yeou Huang, Chien-Yu Chiu, Yu-Shin Huang, Han-Chung Wu
The identification of molecules that are down-regulated in malignant phenotype is important for understanding tumor biology and their role in tumor suppression. We compared the expression profile of four normal nasal mucosal (NNM) epithelia and a series of nasopharyngeal cancinoma (NPC) cell lines using cDNA microarray and confirmed the actual expression of the selected genes, and found osteoprotegerin (OPG) to be ubiquitously deficient in NPC cells. We also found OPG to be down-regulated in various cancer cell lines, including oral, cervical, ovarian, lung, breast, pancreas, colon, renal, prostate cancer, and hepatoma...
September 1, 2009: Journal of Cellular Biochemistry
Carlos Muller Arteaga, Sergio Martín Martín, José R Cortiñas González, José A González Fajardo, Ernesto Fernández del Busto
Vascular retroperitoneal alterations are little frequent and nevertheless, more diagnosed. We presented a case of association very little frequents in which a vascular congenital malformation is related to the presence of a renal arteriovenous fistula and a left renal carcinoma in a patient who only presented hematuria. These vascular variations must be considered at the moment for planning a surgery with the purpose of making it safer and to avoid complications. The case is discussed and literature is reviewed...
January 2009: Actas Urologicas Españolas
Abubaker Shahid, Mohammad Amin Athar, Saeeda Asghar, Tanvir Zubairi, Sohail Murad, Numair Yunas
OBJECTIVES: To compare three hypofractionated protocols in postmastectomy cancinoma breast in terms of local control, toxicity and work load. METHODS: A total of three hundred patients suffering from cancer breast stage T2-4, N any were randomized into three arms after mastectomy. All the patients were treated with four fields on Co60 i.e. two tangential portals for chest wall, one anterior supraclavicular and axillary field and a posterior axillary boost and were randomized into three arms i...
May 2009: JPMA. the Journal of the Pakistan Medical Association
Christos A Papadimitriou, George Fountzilas, Dimitrios Bafaloukos, George Bozas, Haralambos Kalofonos, Dimitrios Pectasides, Gerassimos Aravantinos, Aristotelis Bamias, Meletios-A Dimopoulos et al.
OBJECTIVE: Taxanes, and platinum compounds represent the chemotherapeutic agents with the greatest activity in metastatic endometrial carcinoma. We administered the combination of paclitaxel, topotecan and carboplatin to patients with metastatic or recurrent carcinoma of the endometrium to evaluate its activity and to define its toxicity. METHODS: Thirty-nine consecutive patients were treated on an outpatient basis with paclitaxel 150 mg/m(2), administered intravenously over a 3-h period and followed by carboplatin at AUC of 5 on day 3, with both agents proceding topotecan that was given at 0...
October 2008: Gynecologic Oncology
S Niesporek, W Weichert, B Sinn, A Röske, A Noske, A C Buckendahl, R Wirtz, J Sehouli, D Koensgen, M Dietel, C Denkert
AIMS: NF-kappaB has been demonstrated to activate proliferative, inflammatory, and angiogenic processes in ovarian cancer cells in vitro. To add translational information on the situation in vivo, we determined the expression pattern of p65, an important subunit of the classic NF-kappaB pathway, in ovarian carcinoma tissue, and investigated in vivo and in vitro whether this pathway is implicated in the known overexpression of cyclooxygenase-2 (COX-2). METHODS: p65 siRNA, chemiluminescent NF-kappaB transcription factor assay, Taqman PCR, as well as immunoblotting were performed with OVCAR-3 ovarian cancer cells...
2007: Verhandlungen der Deutschen Gesellschaft Für Pathologie
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