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https://www.readbyqxmd.com/read/29132723/ovarian-sex-cord-stromal-tumours-and-their-mimics
#1
REVIEW
Robert H Young
Sex cord-stromal tumours of the ovary include many of the most morphologically intriguing ovarian neoplasms and albeit many of them are rare, they factor into the differential diagnosis more often than their frequency might suggest. The most common malignant form, the adult granulosa cell tumour, may grossly simulate various surface epithelial neoplasms. Microscopically, confusion with endometrioid carcinoma may occur because the cords and microfollicles of the granulosa cell tumour may be mimicked by endometrioid carcinoma and the latter may have pale nuclei with nuclear grooves...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29131023/evaluation-of-serum-nidogen-2-as-a-screening-and-diagnostic-tool-for-ovarian-cancer
#2
Haitham A Torky, Ahmed Sherif, Ashraf Abo-Louz, Mohamed Ali, Ali Ahmed, Ahmad Ali
INTRODUCTION: Ovarian cancer is a relatively common occurrence with the formation of a tumour in the ovaries and is the leading cause of death in the gynecological field. Despite enormous efforts, there are no successful screening methods developed until now to decrease mortality in this regard. AIM: To evaluate nidogen-2 as a new tumour marker combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound to improve early diagnosis of ovarian cancer...
November 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29119617/computer-aided-design-of-human-sialyltransferase-inhibitors-of-hst8sia-iii
#3
Christopher Dobie, Andrew P Montgomery, Rémi Szabo, Danielle Skropeta, Haibo Yu
Sialyltransferase (ST) upregulation and the resultant hypersialylation of tumour cell surfaces is an established hallmark of many cancers including lung, breast, ovarian, pancreatic and prostate cancer. The role of ST enzymes in tumour cell growth and metastasis, as well as links to multi-drug resistance, has seen ST inhibition emerge as a target for potential antimetastatic cancer treatments. The most potent of these reported inhibitors are transition-state analogues. Although there are several examples of these in the literature, many have suspected poor pharmacokinetic properties and are not readily synthetically accessible...
November 9, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29116111/the-expression-of-mirnas-is-associated-with-tumour-genome-instability-and-predicts-the-outcome-of-ovarian-cancer-patients-treated-with-platinum-agents
#4
Tianzhen Wang, Guangyu Wang, Xiaoxiao Zhang, Di Wu, Lei Yang, Guangyou Wang, Dapeng Hao
miRNAs, a class of short but stable noncoding RNA molecules, have been revealed to play important roles in the DNA damage response (DDR). However, their functions in cancer genome instability and the consequent clinical effect as the response to chemotherapy have not been fully elucidated. In this study, we utilized multidimensional TCGA data and the known miRNAs involved in DDR to identify a miRNA-regulatory network that responds to DNA damage. Additionally, based on the expression of ten miRNAs in this network, we developed a 10-miRNA-score that predicts defects in the homologous recombination (HR) pathway and genome instability in ovarian cancer...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108961/rare-ovarian-tumours-epidemiology-treatment-challenges-in-and-outside-a-network-setting
#5
I Ray-Coquard, AnnaLisa Trama, M J Seckl, C Fotopoulou, P Pautier, S Pignata, G Kristensen, G Mangili, H Falconer, L Massuger, J Sehouli, E Pujade-Lauraine, D Lorusso, F Amant, E Rokkones, I Vergote, J A Ledermann
PURPOSE OF THE REVIEW: More than 50% of all gynaecological cancers can be classified as rare tumours (defined as an annual incidence of <6 per 100,000) and such tumours represent an important challenge for clinicians. RECENT FINDINGS: Rare cancers account for more than one fifth of all new cancer diagnoses, more than any of the single common cancers alone. Reviewing the RARECAREnet database, some of the tumours occur infrequently, whilst others because of their natural history have a high prevalence, and therefore appear to be more common, although their incidence is also rare...
November 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29107859/the-effect-of-the-progesterone-induced-blocking-factor-pibf-on-e-cadherin-expression-cell-motility-and-invasion-of-primary-tumour-cell-lines
#6
Tímea Balassa, Gergely Berta, László Jakab, Noémi Bohonyi, Júlia Szekeres-Bartho
In addition to being immunomodulatory, Progesterone-Induced Blocking Factor (PIBF) plays a role in cell cycle regulation and invasion. The full length protein is associated with the pericentriolar satellites and as such, it is crucial for maintaining the integrity of spindle poles during mitosis. Another suggestive evidence for the involvement of PIBF in tumour progression is the fact that the PIBF gene has been identified on chromosome 13 in the region associated with breast cancer susceptibility. Earlier we showed that PIBF differentially regulates the invasiveness of trophoblast and tumour cell lines...
November 2, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#7
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29103194/astragalus-polysaccharides-increase-the-sensitivity-of-skov3-cells-to-cisplatin
#8
Caihong Li, Li Hong, Cheng Liu, Jie Min, Ming Hu, Wenjun Guo
BACKGROUND: Multidrug resistance in malignant tumours hinders the treatment of tumours. Studies showed that astragalus polysaccharides (APS), one major active ingredient of astragalus, enhanced the sensitivity of non-small cell lung cancer and liver cancer cells to chemotherapeutic drug. However, the effect of APS on ovarian cancer is still unclear. In this study, we will examine the sensitizing effect of APS on SKOV3 cells to cisplatin and explore the possible mechanism. METHODS: MTT assay was employed to examine the viability of SKOV3 after treatment with APS and cisplatin...
November 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29100532/a-comprehensive-overview-of-exosomes-in-ovarian-cancer-emerging-biomarkers-and-therapeutic-strategies
#9
REVIEW
Lin Cheng, Shuying Wu, Kun Zhang, Yun'an Qing, Tianmin Xu
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs...
November 3, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29098421/what-is-the-accuracy-of-frozen-section-in-the-diagnosis-of-mucinous-ovarian-tumours-a-9-year-review-of-performance-in-a-greek-tertiary-referral-centre
#10
Anastasios Tranoulis, Nikolaos Thomakos, Maria Sotiropoulou, Alexandros Rodolakis
PURPOSE: This retrospective study aimed to evaluate the diagnostic accuracy of the intra-operative frozen sections (FS) of mucinous ovarian tumours (mOT). METHODS: Between 2007 and 2015, a total of 105 mucinous ovarian samples were collected during laparotomy. The intra-operative FS accuracy was evaluated and potential factors correlated with increased inaccuracy assessed using both univariate and multivariate analysis. RESULTS: The overall FS accuracy was 82...
November 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29096339/krukenberg-s-tumour-unilateral-giant-metachronous-of-colonic-origin-case-report
#11
Luciano Zogbi, Angélica Isaías, Pedro Augusto Machado, Aluísio Neutzling, Camila Juliano
INTRODUCTION: Krukenberg tumour (KT) is defined by the World Health Organization as a metastatic ovary carcinoma, usually of gastric origin. The term has also been applied to metastatic tumors originating from adenocarcinomas of other sites, such as the colon. After radical resection of colorectal carcinoma, metachronous ovarian metastases can occur in 1.1% of cases. Due to their rarity and rapid progression, KTs needs a high level of suspicion. Here we present an atypical case of KT and highlight the importance of the timely recognition of this disease...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29089859/the-impact-of-%C3%AE-irradiation-on-the-induction-of-bystander-killing-by-genetically-engineered-ovarian-tumor-cells-implications-for-clinical-use
#12
Jehad Zweiri, Stephen E Christmas
BACKGROUND: Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used in some studies to compare the in vitro and in vivo efficacy of autologous vs allogeneic tumour cell vaccines. METHODS: This study examines the effect of γ-irradiation on a range of tumor cell lines in conjunction with suicide gene therapy of cancer...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29082766/new-developments-and-clinical-transition-of-hyaluronic-acid-based-nanotherapeutics-for-treatment-of-cancer-reversing-multidrug-resistance-tumour-specific-targetability-and-improved-anticancer-efficacy
#13
Muhammad Hassan Safdar, Zahid Hussain, Mohammed A S Abourehab, Humna Hasan, Sajal Afzal, Hnin Ei Thu
This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells...
October 30, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29079174/mir-223-potentially-targets-swi-snf-complex-protein-smarcd1-in-atypical-proliferative-serous-tumor-and-high-grade-ovarian-serous-carcinoma
#14
Florence A Arts, Lisa Keogh, Paul Smyth, Sharon O'Toole, Robert Ta, Noreen Gleeson, John J O'Leary, Richard Flavin, Orla Sheils
Ovarian cancer is the fifth most common cancer in women worldwide and has the highest mortality amongst gynecological cancers. miRNAs are a class of non-coding RNAs, approximately 22 nt long, that negatively regulate gene expression and to have roles in cell growth, differentiation, metabolism, apoptosis and tumorigenesis. Dysregulated miRNA-223 expression has been implicated in a wide range of cancer subtypes. SMARCD1 is an integral protein component of the SWI/SNF complex which remodels chromatin, and which has important roles in transcriptional control, DNA replication, recombination and repair...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29079036/apela-promotes-tumour-growth-and-cell-migration-in-ovarian-cancer-in-a-p53-dependent-manner
#15
Yuyin Yi, Shu-Huei Tsai, Jung-Chien Cheng, Evan Y Wang, Michael S Anglesio, Dawn R Cochrane, Megan Fuller, Ewan A Gibb, Wei Wei, David G Huntsman, Aly Karsan, Pamela A Hoodless
OBJECTIVE: APELA is a small, secreted peptide that can function as a ligand for the G-protein coupled receptor, Apelin Receptor (APLNR, APJ). APELA plays an essential role in endoderm differentiation and cardiac development during embryogenesis. We investigated whether APELA exerts any functions in cancer progression. METHODS: The Cancer Genome Atlas (TCGA) RNA sequencing datasets, microarray from an OCCC mouse model, and RNA isolated from fresh frozen and FFPE patient tissue were used to assess APELA expression...
October 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29078115/only-complete-tumour-resection-after-neoadjuvant-chemotherapy-offers-benefit-over-suboptimal-debulking-in-advanced-ovarian-cancer
#16
Carolien K M Vermeulen, Workineh Tadesse, Maite Timmermans, Roy F P M Kruitwagen, Tom Walsh
OBJECTIVE: The aim of this study was to compare surgical results and survival outcome of advanced ovarian cancer patients who were treated with primary versus interval debulking surgery. STUDY DESIGN: In this retrospective study stage III and IV ovarian cancer patients who received debulking surgery from 2006 to 2015 were included. Surgical results were described as complete, optimal or suboptimal debulking and chi-square test was used to assess significant differences...
October 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29070997/recurrence-of-ovarian-cancer-with-placental-metastasis-a-case-report
#17
Michiko Honda, Manabu Yamada, Toshio Kumasaka, Taiki Samejima, Hirohisa Satoh, Mitsuhiro Sugimoto
A 39-year-old primiparous Japanese female was admitted to the obstetrical emergency department of our hospital because of respiratory distress resulting from a large amount of pleural effusion, soon after a caesarean delivery (CD) at another hospital. While she was undergoing the CD, a giant ovarian tumour was identified. However, the tumour could not be removed at that facility and she was transferred to our hospital. Three days after the CD, a left salpingo-oophorectomy was performed with the purpose of controlling pleural and peritoneal effusions...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29070896/a-formulation-of-pancreatic-pro-enzymes-provides-potent-anti-tumour-efficacy-a-pilot-study-focused-on-pancreatic-and-ovarian-cancer
#18
Macarena Perán, Elena López-Ruiz, María Ángel García, Shorena Nadaraia-Hoke, Ralf Brandt, Juan A Marchal, Julian Kenyon
Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and Chymotrypsinogen A was determined at a ratio 1:6 (named PRP) using 24 human cancer cell lines. The antiangiogenic effect of PRP was analysed by matrigel-based tube formation and by fibrous capsule formation assays. Furthermore, cell invasion and wound healing assays together with qRT-PCR determination of epithelial-to-mesenchymal transition (EMT) markers were performed on human cancer cells treated with PRP...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066646/recurrence-of-immature-ovarian-teratoma-as-malignant-follicular-carcinoma-with-liver-and-peritoneal-metastasis-22-years-after-completion-of-initial-treatment
#19
Nicholas Brian Shannon, Norman Hok Ling Chan, Melissa Ching Ching Teo
Growing tumour syndrome (GTS) is a rare event in which germ cell tumours treated with chemotherapy undergo maturation, acquire resistance to chemotherapy and regrow. The optimum treatment strategy is complete surgical excision. We report on a case of GTS with malignant metastases to the liver presenting 22 years after completion of treatment for immature teratoma, successfully managed with surgical resection alone.
October 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29065108/towards-gene-and-gender-based-risk-estimates-in-lynch-syndrome-age-specific-incidences-for-13-extra-colorectal-cancer-types
#20
Christina Therkildsen, Steen Ladelund, Lars Smith-Hansen, Lars Joachim Lindberg, Mef Nilbert
BACKGROUND: In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study design, we aimed to determine the risk of extra-colorectal cancer and to identify yet unrecognised tumour types. METHODS: Data from 1624 Lynch syndrome mutation carriers in the Danish hereditary non-polyposis colorectal cancer register were used to estimate the sex- and age-specific incidence rate ratios (IRRs) for 30 extra-colorectal malignancies with comparison to the general population...
October 24, 2017: British Journal of Cancer
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