keyword
https://read.qxmd.com/read/38525078/characterization-of-es10-lytic-bacteriophage-isolated-from-hospital-waste-against-multidrug-resistant-uropathogenic-e-coli
#21
JOURNAL ARTICLE
Aneela Nawaz, Sabeena Zafar, Abdulrahman H Alessa, Nauman Ahmed Khalid, Muqaddas Shahzadi, Alina Majid, Malik Badshah, Aamer Ali Shah, Samiullah Khan
Escherichia coli is the major causative agent of urinary tract infections worldwide and the emergence of multi-drug resistant determinants among clinical isolates necessitates the development of novel therapeutic agents. Lytic bacteriophages efficiently kill specific bacteria and seems promising approach in controlling infections caused by multi-drug resistant pathogens. This study aimed the isolation and detailed characterization of lytic bacteriophage designated as ES10 capable of lysing multidrug-resistant uropathogenic E...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38525020/hierarchical-porous-bimetallic-femn-metal-organic-framework-gel-for-efficient-activation-of-peracetic-acid-in-antibiotic-degradation
#22
JOURNAL ARTICLE
Lu Zheng, Jiarui Fu, Baolv Hua, Yi-Nan Wu, Yifan Gu, Nianqiao Qin, Fengting Li
Effective techniques for eliminating antibiotics from water environments are in high demand. The peracetic acid (PAA)-based advanced oxidation process has recently drawn increasing attention for its effective antibiotic degrading capability. However, current applications of PAA-based techniques are limited and tend to have unsatisfactory performance. An additional catalyst for PAA activation could provide a promising solution to improve the performance of PAA. Bulky metal-organic framework gels (MOGs) stand out as ideal catalysts for PAA activation owing to their multiple advantages, including large surface areas, high porosity, and hierarchical pore systems...
March 20, 2024: ACS Environ Au
https://read.qxmd.com/read/38524454/bioinspired-stevia-rebaudiana-green-zinc-oxide-nanoparticles-for-the-adsorptive-removal-of-antibiotics-from-water
#23
JOURNAL ARTICLE
Hania A Guirguis, Noha Youssef, Mariam William, Dania Abdel-Dayem, Mayyada M H El-Sayed
Green zinc oxide nanoparticles (ZnO NPs) synthesized using Stevia rebaudiana as a reducing agent were investigated as ecofriendly adsorbents for the removal of the antibiotics ciprofloxacin (CIP) and tetracycline (TET) from water. Green ZnO NPs were synthesized using a rapid novel approach that did not require annealing or calcination at high temperatures to produce mesoporous NPs with a size range of 37.36-71.33 nm, a specific surface area of 15.28 m2 /g, and a negative surface charge of -15 mV at pH 5. The green ZnO NPs exhibited an antioxidant activity of 85...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523339/review-of-quorum-quenching-probiotics-a-promising-non-antibiotic-based-strategy-for-sustainable-aquaculture
#24
REVIEW
Anisa Rilla Lubis, Md Afsar Ahmed Sumon, Nguyen Dinh-Hung, Arun K Dhar, Jérôme Delamare-Deboutteville, Do-Hyung Kim, Andrew P Shinn, Duangkhaetita Kanjanasopa, Patima Permpoonpattana, Hien Van Doan, Nguyen Vu Linh, Christopher L Brown
The emergence of antibiotic-resistant bacteria (ARBs) and genes (ARGs) in aquaculture underscores the urgent need for alternative veterinary strategies to combat antimicrobial resistance (AMR). These measures are vital to reduce the likelihood of entering a post-antibiotic era. Identifying environmentally friendly biotechnological solutions to prevent and treat bacterial diseases is crucial for the sustainability of aquaculture and for minimizing the use of antimicrobials, especially antibiotics. The development of probiotics with quorum-quenching (QQ) capabilities presents a promising non-antibiotic strategy for sustainable aquaculture...
March 24, 2024: Journal of Fish Diseases
https://read.qxmd.com/read/38522841/phage-resistance-in-klebsiella-pneumoniae-and-bidirectional-effects-impacting-antibiotic-susceptibility
#25
JOURNAL ARTICLE
Sue C Nang, Jing Lu, Heidi H Yu, Hasini Wickremasinghe, Mohammad A K Azad, Meiling Han, Jinxin Zhao, Gauri Rao, Phillip J Bergen, Tony Velkov, Norelle Sherry, David T McCarthy, Saima Aslam, Robert T Schooley, Benjamin P Howden, Jeremy J Barr, Yan Zhu, Jian Li
OBJECTIVES: Bacteriophage (phage) therapy is a promising anti-infective option to combat antimicrobial resistance. However, the clinical utilisation of phage therapy has been severely compromised by the potential emergence of phage resistance. While certain phage resistance mechanisms can restore bacterial susceptibility to certain antibiotics, a lack of knowledge of phage resistance mechanisms hinders optimal use of phages and their combination with antibiotics. METHODS: Genome-wide transposon screening was performed with a mutant library of Klebsiella pneumoniae MKP103 to identify phage pKMKP103_1-resistant mutants...
March 22, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38522673/insights-into-levofloxacin-adsorption-with-machine-learning-models-using-nano-composite-hydrochars
#26
JOURNAL ARTICLE
Alaa El Din Mahmoud, Radwa Ali, Manal Fawzy
Hydrothermal carbonization was applied to taro peel wastes to produce hydrochars in a facile environmentally friendly process. Four different entities were prepared: hydrochar (TPh), phosphoric-activated hydrochar (P-TPh) and silver@hydrochars (Ag@TPh, Ag@P-TPh). The elemental compositions of the single and composite hydrochars were confirmed by EDX. Among the produced hydrochars, the morphology of the Ag@hydrochar composites demonstrated more wrinkled structure and Ag nanoparticles decorated the surface. The optimal experimental conditions for levofloxacin adsorption were determined to be contact time of 45 min, hydrochar dose of 0...
March 22, 2024: Chemosphere
https://read.qxmd.com/read/38522429/the-efficacy-of-nursing-interventions-in-preventing-surgical-site-infections-in-patients-undergoing-surgery-for-congenital-heart-disease
#27
JOURNAL ARTICLE
Ping He, Yue Hai
Surgical site infections (SSIs) pose significant risks to patients undergoing surgery for congenital heart disease (CHD), impacting recovery and increasing healthcare burdens. This study assesses the efficacy of targeted nursing interventions in reducing SSIs and enhancing wound healing in this vulnerable patient group. A prospective cohort study was conducted from January 2022 to August 2023 at a single institution, involving 120 paediatric patients divided into control (standard postoperative care) and observation (specialized nursing interventions) groups...
April 2024: International Wound Journal
https://read.qxmd.com/read/38521228/hungatella-hathewayi-bacteremia-due-to-acute-appendicitis-a-case-report-and-a-narrative-review
#28
Elie Bou Sanayeh, Mark Tawfik, Marina Makram, Georges Khattar, Faris Qaqish, Sudeep Acharya, Janet Farag, Michel Chalhoub, Allison Glaser
Hungatella species, including Hungatella hathewayi and Hungatella effluvii, previously identified as part of the Clostridium genus, are anaerobic bacteria primarily residing in the gut microbiome, with infrequent implications in human infections. This article presents the case of an 87-year-old Asian male admitted for a hyperosmolar hyperglycemic state with septic shock secondary to Hungatella hathewayi bacteremia originating from acute appendicitis. Remarkably, the bacterium was detected in the blood 48 hours before the emergence of clinical and radiographic evidence of acute appendicitis...
March 21, 2024: Anaerobe
https://read.qxmd.com/read/38519025/simultaneous-post-neurosurgical-ventriculitis-and-bacteremia-by-two-different-strains-of-kpc-producing-k-pneumoniae-successfully-treated-with-meropenem-vaborbactam-and-high-dose-of-fosfomycin
#29
JOURNAL ARTICLE
Lorenzo Volpicelli, Sara Cairoli, Dania Al Ismail, Floriana Baisi, Federica Sacco, Bianca Maria Goffredo, Mario Venditti, Alessandra Oliva
A case of post-neurosurgical ventriculitis caused by a KPC-producing Klebsiella pneumoniae (KPC-Kp) with a ceftazidime/avibactam-resistant, meropenem-susceptible phenotype is reported. The patient had a concomitant bloodstream infection with a wild-type KPC-Kp with a ceftazidime/avibactam-susceptible, meropenem-resistant phenotype. Prolonged treatment with intravenous fosfomycin and meropenem/vaborbactam achieved clinical success. Therapeutic drug monitoring performed during the first days of treatment showed for the first time that vaborbactam efficiently penetrates cerebrospinal fluid...
March 20, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38519004/coordinated-elimination-of-bacterial-taxa-optimally-attenuates-alloimmunity-and-prolongs-allograft-survival
#30
JOURNAL ARTICLE
Martin Sepulveda, Mladen Rasic, Yuk Man Lei, Montserrat Kwan, Luqiu Chen, Yang Chen, David Perkins, Maria-Luisa Alegre
This study aimed to dissect the relationship between specific gut commensal bacterial subgroups, their functional metabolic pathways, and their impact on skin allograft outcome and alloimmunity. We previously showed that oral broad-spectrum antibiotic pre-treatment in mice delayed skin, heart and lung allograft rejection and dampened alloimmune responses. Here, rationally designed antibiotic combinations targeting major bacterial groups were used to elucidate their individual contribution to modulating alloimmune responses...
March 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38517875/a-systematic-review-and-meta-analysis-on-the-efficacy-of-vaccination-against-colibacillosis-in-broiler-production
#31
JOURNAL ARTICLE
Surya Paudel, Ilias Apostolakos, Ronald Vougat Ngom, Giuditta Tilli, Helena C de Carvalho Ferreira, Alessandra Piccirillo
Colibacillosis, a disease caused by Escherichia coli in broiler chickens has serious implications on food safety, security, and economic sustainability. Antibiotics are required for treating the disease, while vaccination and biosecurity are used for its prevention. This systematic review and meta-analysis, conducted under the COST Action CA18217-European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT), aimed to assess the efficacy of E. coli vaccination in broiler production and provide evidence-based recommendations...
2024: PloS One
https://read.qxmd.com/read/38517707/prevalence-and-characteristics-of-ertapenem-mono-resistant-isolates-among-carbapenem-resistant-enterobacterales-in-china
#32
JOURNAL ARTICLE
Yinping Wang, Huangdu Hu, Qiucheng Shi, Ping Zhang, Dongdong Zhao, Yan Jiang, Yunsong Yu
Abstract Carbapenem-resistant Enterobacterales (CRE), specifically those resistant to only ertapenem among carbapenems (ETP-mono-resistant), are increasingly reported, while the optimal therapy options remain uncertain. To investigate the prevalence and characteristics of ETP-mono-resistant CRE, CRE strains were systematically collected from 102 hospitals across China between 2018 and 2021. A 1:1 randomized matching study was conducted with ETP-mono-resistant strains to meropenem- and/or imipenem-resistant (MEM/IPM-resistant) strains...
March 22, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38517437/antibiotic-use-in-late-preterm-and-full-term-newborns
#33
JOURNAL ARTICLE
Johan Gyllensvärd, Marie Studahl, Lars Gustavsson, Elisabet Hentz, Karin Åkesson, Huiqi Li, Mikael Norman, Anders Elfvin
IMPORTANCE: Antibiotic treatment saves lives in newborns with early-onset sepsis (EOS), but unwarranted antibiotic use is associated with resistant bacteria and adverse outcomes later in life. Surveillance is needed to optimize treatment strategies. OBJECTIVE: To describe antibiotic use in association with the incidence and mortality from EOS among late-preterm and full-term newborns. DESIGN, SETTING, AND PARTICIPANTS: The Sweden Neonatal Antibiotic Use study was a nationwide observational study that included all late-preterm and full-term neonates born from January 1, 2012, to December 31, 2020, in neonatal units of all levels...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38517129/associations-between-health-behaviors-gastrointestinal-symptoms-and-gut-microbiota-in-a-cross-sectional-sample-of-cancer-survivors-secondary-analysis-from-the-chemo-gut-study
#34
JOURNAL ARTICLE
Julie M Deleemans, Faye Chleilat, Raylene A Reimer, Oluwaseyi A Lawal, Mohamad Baydoun, Katherine-Ann Piedalue, Dana E Lowry, Linda E Carlson
BACKGROUND: Health behaviors, such as diet and exercise, are actions individuals take that can potentially impact gastrointestinal (GI) symptoms and the gut microbiota. Little is known about how health behaviors impact GI symptoms and the gut microbiota after anti-cancer therapies. METHODS: This is a secondary analysis of a cross-sectional study that investigated relationships between GI symptoms, gut microbiota, and patient-reported outcomes in adult cancer survivors...
2024: Integrative Cancer Therapies
https://read.qxmd.com/read/38516949/optimization-and-validation-of-an-ftir-based-all-in-one-system-for-viable-mdr-bacteria-detection-in-combat-related-wound-infection
#35
JOURNAL ARTICLE
Ying Chen, Andrew Leung, Yulia Wang, Nathan K Archer
INTRODUCTION: The U.S. Military members experiencing combat-related injuries have a higher chance of developing infections by multidrug-resistant (MDR) bacteria at admission to military hospitals. MDR wound infections result in higher amputation rates and greater risks for subsequent or chronic infections that require readmission or extended stay in the hospital. Currently, there is no FDA-clear, deployable early diagnostic system for suitable field use.We are reporting our efforts to improve a previously developed Rapid Label-free Pathogen Identification (RAPID) system to detect viable MDR bacteria in wound infections and perform antibiotic susceptibility testing (AST)...
March 21, 2024: Military Medicine
https://read.qxmd.com/read/38516601/application-of-tobramycin-benzyl-ether-as-an-antibiotic-adjuvant-capable-of-sensitizing-multidrug-resistant-gram-negative-bacteria-to-rifampicin
#36
JOURNAL ARTICLE
Danzel Marie Ramirez, Shiv Dhiman, Ayan Mukherjee, Ruwani Wimalasekara, Frank Schweizer
The emergence of aminoglycoside resistance has prompted the development of amphiphilic aminoglycoside derivatives which target bacterial membranes. Tobramycin and nebramine ether derivatives initially designed for this purpose were optimized and screened for their potential application as outer membrane (OM) permeabilizing adjuvants. Structure-activity relationship (SAR) studies revealed that the tobramycin benzyl ether was the most optimal OM permeabilizer, capable of potentiating rifampicin, novobiocin, vancomycin, minocycline, and doxycycline against Gram-negative bacteria...
March 20, 2024: RSC medicinal chemistry
https://read.qxmd.com/read/38514663/molecular-docking-molecular-dynamics-simulations-and-binding-free-energy-studies-of-interactions-between-mycobacterium-tuberculosis-pks13-pkng-and-bioactive-constituents-of-extremophilic-bacteria
#37
JOURNAL ARTICLE
Kudakwashe Nyambo, Kudzanai Ian Tapfuma, Francis Adu-Amankwaah, Lauren Julius, Lucinda Baatjies, Idah Sithole Niang, Liezel Smith, Krishna Kuben Govender, Mkhuseli Ngxande, Daniel J Watson, Lubbe Wiesner, Vuyo Mavumengwana
Mycobacterial pathogens present a significant challenge to disease control efforts globally due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of Mycobacterium tuberculosis has prompted an urgent need for innovative therapeutic solutions. One promising way to discover new tuberculosis drugs is by utilizing natural products from the vast biochemical space. Multidisciplinary methods can used to harness the bioactivity of these natural products. This study aimed to evaluate the antimycobacterial efficacy of functional crude extracts from bacteria isolated from gold mine tailings in South Africa...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38513409/direct-z-scheme-system-of-uio-66-cubes-wrapped-with-zn-0-5-cd-0-5-s-nanoparticles-for-photocatalytic-hydrogen-generation-synchronized-with-organic-pollutant-degradation
#38
JOURNAL ARTICLE
Dongfang Hou, Qian Zhu, Junjie Wang, Min Deng, Xiu-Qing Qiao, Bojing Sun, Qingwen Han, Ruan Chi, Dong-Sheng Li
Optimized fabrication of Z-scheme photocatalyst based on MOF materials offers sustainable energy generation and environmental improvement due to their attractive properties. The Z-scheme heterojunctions consisting of UiO-66 cubes covered with Zn0.5 Cd0.5 S nanoparticles were fabricated by a facile solvothermal method. Thanks to the Z-scheme carrier transport under simulated sunlight irradiation, [email protected] Cd0.5 S exhibited enhanced photocatalytic performance of H2 generation synchronized with organic pollutant degradation in fluoroquinolone antibiotic wastewater...
March 17, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38513340/recent-advances-in-the-exploration-of-oxazolidinone-scaffolds-from-compound-development-to-antibacterial-agents-and-other-bioactivities
#39
REVIEW
Maxwell Ampomah-Wireko, Shengcong Chen, Ruirui Li, Chen Gao, Meng Wang, Ye Qu, Hongtao Kong, Lauraine Nininahazwe, En Zhang
Bacterial infections cause a variety of life-threatening diseases, and the continuous evolution of drug-resistant bacteria poses an increasing threat to current antimicrobial regimens. Gram-positive bacteria (GPB) have a wide range of genetic capabilities that allow them to adapt to and develop resistance to practically all existing antibiotics. Oxazolidinones, a class of potent bacterial protein synthesis inhibitors with a unique mechanism of action involving inhibition of bacterial ribosomal translation, has emerged as the antibiotics of choice for the treatment of drug-resistant GPB infections...
March 13, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38511344/mannan-oligosaccharides-promote-gut-microecological-recovery-after-antibiotic-disturbance
#40
JOURNAL ARTICLE
Jing Chen, Jialin Yin, Heqiang Xie, Wenwei Lu, Hongchao Wang, Jianxin Zhao, Jinlin Zhu
Antibiotic treatment often causes collateral damage to the gut microbiota, including changes in its diversity and composition. Dietary fiber helps maintain intestinal health, regulate short-chain fatty acids, and promote the recovery of the intestinal microbiome. However, it is currently unknown which specific plant-based dietary fiber is optimal as a dietary supplement for restoring the intestinal microbiota after antibiotic disturbance. Previously, we proposed predictive recovery-associated bacterial species (p-RABs) and identified the most important interventions...
March 21, 2024: Food & Function
keyword
keyword
115928
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.