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https://www.readbyqxmd.com/read/29331911/enhanced-photocatalytic-degradation-of-sulfamethoxazole-by-zinc-oxide-photocatalyst-in-the-presence-of-fluoride-ions-optimization-of-parameters-and-toxicological-evaluation
#1
Amir Mirzaei, Laleh Yerushalmi, Zhi Chen, Fariborz Haghighat, Jianbo Guo
The presence of antibiotics in water bodies has received increasing attention since they are continuously introduced and detected in the environment and may cause unpredictable environmental hazards and risks. The photocatalytic degradation of sulfamethoxazole (SMX) by ZnO in the presence of fluoride ions (F-ZnO) was evaluated. The effects of operating parameters on the efficiency of SMX removal were investigated by using response surface methodology (RSM). Under the optimum condition, i.e. photocatalyst dosage = 1...
January 11, 2018: Water Research
https://www.readbyqxmd.com/read/29324505/when-to-switch-to-an-oral-treatment-and-or-to-discharge-a-patient-with-skin-and-soft-tissue-infections
#2
Matteo Bassetti, Christian Eckmann, Maddalena Peghin, Alessia Carnelutti, Elda Righi
PURPOSE OF REVIEW: Skin and soft tissue infections prevalence is increasing and represent a frequent cause of hospital admission. New guidelines have become available in order to better define these infections and their response to antimicrobial treatment. Gram-positive bacteria, in particular Staphylococcus aureus, remain the most frequently isolated pathogens in skin and soft tissue infections. To treat complicated forms and infections caused by drug-resistant bacteria, hospital admission and administration of intravenous antibiotics are often required, impacting on healthcare costs and patients' morbidity...
January 10, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29324478/site-of-entry-and-surgical-timing-in-infective-endocarditis
#3
Francesco Bovenzi, Lucia Borelli, Lauro Cortigiani
: Infective endocarditis is the manifestation of the endocardial involvement during a systemic infectious process.The prognosis of this condition is still dismal, and the mortality associated with it remains high despite improvement in antimicrobial treatment. Antibiotic prophylaxis is still recommended only in high-risk cases, that is, procedures at high risk for inducing systemic bacteremia.It is important to provide an educational prophylaxis consisting of sound hygienic recommendations for the cleansing of the oral cavity, the skin, genital-urinary, and gastrointestinal systems...
January 10, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29323910/direct-synthesis-of-prussian-blue-nanoparticles-in-liposomes-incorporating-natural-ion-channels-for-cs-adsorption-and-particle-size-control
#4
Tomomi Koshiyama, Motoki Tanaka, Masayuki Honjo, Yumi Fukunaga, Tomoya Okamura, Masaaki Ohba
Coordination polymer (CP) nanoparticles (NPs) formed by a self-assembly of organic ligands and metal ions are one of the attractive materials for molecular capture and deliver/release in aqueous media. Control of particle size and prevention of aggregation among CP NPs are important factors for improving their adsorption capability in water. We demonstrate here the potential of a liposome incorporating an antibiotic ion channel as a vessel for synthesizing Prussian blue (PB) NPs, being a typical CP. In the formation of PB NPs within liposomes, the influx rate of Fe2+ ions into liposome encapsulated [Fe(CN)6]3- through channels was fundamental for the change of NPs' sizes...
January 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29322461/enhanced-methodologies-for-detecting-phenotypic-resistance-in-mycobacteria
#5
Robert J H Hammond, Vincent O Baron, Sam Lipworth, Stephen H Gillespie
Lipid droplets found in algae and other microscopic organisms have become of interest to many researchers partially because they carry the capacity to produce bio-oil for the mass market. They are of importance in biology and clinical practice because their presence can be a phenotypic marker of an altered metabolism, including reversible resistance to antibiotics, prompting intense research.A useful stain for detecting lipid bodies in the lab is Nile red. It is a dye that exhibits solvatochromism; its absorption band varies in spectral position, shape and intensity with the nature of its solvent environment, it will fluoresce intensely red in polar environment and blue shift with the changing polarity of its solvent...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321384/discovery-of-a-novel-fluoroquinolone-antibiotic-candidate-wfq-228-with-potent-antimicrobial-activity-and-the-potential-to-overcome-major-drug-resistance
#6
Tatsuya Hirano, Tomohiko Kinoshita, Daichi Kazamori, Satoshi Inoue, Kouji Nishimura, Asuka Sakurai, Kensuke Ohishi, Yasuhiro Kuramoto, Hirotaka Amano, Akira Yazaki
WFQ-101 with a unique N-1 substituent, 5-amino-4-fluoro-2-(hydroxymethyl)phenyl group, was selected as a lead compound through combination screening based on antimicrobial activity and the efflux index against quinolone-resistant (QR) Pseudomonas aeruginosa (P. aeruginosa). Through structural optimization, we identified WFQ-228 as a novel fluoroquinolone antibiotic candidate. WFQ-228 had potent and superior activity in comparison to levofloxacin (LVX) and ciprofloxacin (CIP) against clinical isolates of P. aeruginosa, Escherichia coli and Acinetobacter baumannii, including QR strains...
January 11, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29319843/prediction-of-vancomycin-dose-for-recommended-trough-concentrations-in-pediatric-patients-with-cystic-fibrosis
#7
Raid W Amin, Rodney P Guttmann, Quianna R Harris, Janesha W Thomas
Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus. The present study sought to develop a model based on empirical evidence of optimal vancomycin dose as judged by clinical observations that could accelerate the achievement of desired trough level in children with cystic fibrosis. Transformations of dose and trough were used to arrive at regression models with excellent fit for dose based on weight or age for a target trough...
January 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29319521/polish-physicians-attitudes-towards-antibiotic-prescription-and-antimicrobial-resistance
#8
Beata Mazińska, Waleria Hryniewicz
Antimicrobial resistance has been one of the biggest global current issues in medicine and public health. Overuse and imprudent use of antimicrobial agents are recognized as one of the leading causes of antibiotic resistance. The aim of this study was to analyze the attitudes of Polish physicians practicing at the community level towards antibiotics and antimicrobial resistance. The majority of physicians taking part in the survey believed that Polish people overuse antibiotics (98%). Most physicians (91%) considered that antimicrobial resistance is a major problem at present...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29318940/thermodynamics-of-the-interaction-between-antibiotics-and-extracellular-polymeric-substances-within-activated-sludge
#9
Cheng-Cheng Zhang, Jin-Song Guo, You-Peng Chen, Fang-Ying Ji, Jing Wang, Peng Yan, Yun Bai
The removal of antibiotics in biological wastewater treatment plants has attracted an ever-increasing interest. Extracellular polymeric substances (EPS) play a crucial role in antibiotics bio-adsorption using activated sludge, but the interaction mechanism between antibiotics and EPS remains unclear. In this study, the thermodynamics of interactions between extracellular polymeric substances (EPS) and antibiotics (acetaminophen (ACT) and sulfamethazine (SMZ)) were investigated via isothermal titration calorimetry (ITC)...
January 10, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29313072/-antibiotic-stewardship-measures-for-optimizing-prescription-of-anti-infective-agents
#10
REVIEW
C Lanckohr, H Bracht
Antibiotic stewardship (ABS) comprises a bundle of different interventions to improve anti-infective treatment in a hospital setting. An important component of ABS interventions is the interdisciplinary approach to infection management. Besides improving infrastructural aspects on a hospital level, including surveillance of the use of anti-infective agents and nosocomial infections, collation and interpretation of statistics on resistance and formulation of local treatment guidelines, ABS teams go to the wards and advise treating physicians on antibiotic therapy...
January 8, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29310479/therapies-for-multidrug-resistant-and-extensively-drug-resistant-non-fermenting-gram-negative-bacteria-causing-nosocomial-infections-a-perilous-journey-toward-molecularly-targeted-therapy
#11
Nadim G El Chakhtoura, Elie Saade, Alina Iovleva, Mohamad Yasmin, Brigid Wilson, Federico Perez, Robert A Bonomo
Non-fermenting Gram-negative bacilli are at the center of the antimicrobial resistance epidemic. Acinetobacter baumannii and Pseudomonas aeruginosa are both designated with a threat level to human health of "serious" by the Centers for Disease Control and Prevention. Two other major non-fermenting Gram-negative bacilli, Stenotrophomonas maltophilia and Burkholderia cepacia complex, while not as prevalent, have devastating effects on vulnerable populations, such as those with cystic fibrosis, as well as immunosuppressed or hospitalized patients...
January 9, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29305961/no-effect-of-vancomycin-mic-%C3%A2-1-5-mg-l-on-treatment-outcome-in-methicillin-susceptible-staphylococcus-aureus-bacteremia
#12
Kevin Bouiller, Caroline Laborde, Serge Ludwig Aho, Didier Hocquet, André Pechinot, Vincent Le Moing, Xavier Bertrand, Lionel Piroth, Catherine Chirouze
OBJECTIVES: The vancomycin minimum inhibitory concentration (MIC) has been shown to affect the outcome of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. In this study, the outcomes of patients with MSSA bacteremia, with a vancomycin MIC≥ 1.5 mg/L were assessed. METHODS: A prospective cohort of patients with MSSA bacteremia in two tertiary-care hospitals was collected. Vancomycin MIC was determined by Etest. SA strains were categorized as low (<1...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29305368/treatment-of-a-complex-orthopaedic-infection-due-to-extensively-drug-resistant-pseudomonas-aeruginosa
#13
Sidra Hassan, Mani D Kahn, Nidhi Saraiya, Priya Nori
According to the Centers for Disease Control and Prevention (CDC), approximately 51 000 healthcare-associated infections caused by Pseudomonas aeruginosa occur annually in the USA, more than 6000 of which (13%) are caused by multidrug resistant (MDR) strains. Ceftolozane/tazobactam (TOL/TAZ) (Zerbaxa) was approved by the US Food and Drug Administration (FDA) in December 2014 for the treatment of complicated intra-abdominal and urinary tract infections. At this time, clinical data on the role of TOL/TAZ treatment outside of FDA-approved indications is limited...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29303731/classifying-antibiotics-in-the-who-essential-medicines-list-for-optimal-use-be-aware
#14
Mike Sharland, Celine Pulcini, Stephan Harbarth, Mei Zeng, Sumanth Gandra, Shrey Mathur, Nicola Magrini
No abstract text is available yet for this article.
January 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29300785/management-of-minor-ailments-in-a-community-pharmacy-setting-findings-from-simulated-visits-and-qualitative-study-in-gondar-town-ethiopia
#15
Asnakew Achaw Ayele, Abebe Basazn Mekuria, Henok Getachew Tegegn, Begashaw Melaku Gebresillassie, Alemayehu Birhane Mekonnen, Daniel Asfaw Erku
Community pharmacy professionals are being widely accepted as sources of treatment and advice for managing minor ailments, largely owing to their location at the heart of the community. The aim of the present study was, therefore, to document the involvement of community pharmacy professionals in the management of minor ailments and perceived barriers that limit their provision of such services. Simulated patient (SP) visits combined with a qualitative study using in-depth interviews was conducted among community pharmacy professionals in Gondar town, Northwest Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29300254/postoperative-catheter-management-after-pelvic-reconstructive-surgery-a-survey-of-practice-strategies
#16
Sarah S Boyd, Elena Tunitsky-Bitton, David M OʼSullivan, Adam C Steinberg
OBJECTIVE: The aim of this study was to evaluate practice preferences in catheter management after a failed inpatient voiding trial after pelvic reconstructive surgery. METHODS: This is a cross-sectional study of postoperative catheter management after pelvic reconstructive surgery after failed voiding trial. Physicians practicing at ACGME-accredited residencies and fellowships in Obstetrics and Gynecology (Ob/Gyn), Urology, and Female Pelvic Medicine and Reconstructive Surgery (FPMRS) within the United States completed a Web-based questionnaire in March 2017...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29298133/epidemiology-and-risk-factors-for-isolation-of-multi-drug-resistant-organisms-in-patients-with-complicated-intra-abdominal-infections
#17
Francesco M Labricciosa, Massimo Sartelli, Lilian M Abbo, Pamela Barbadoro, Luca Ansaloni, Federico Coccolini, Fausto Catena
BACKGROUND: Patients with complicated intra-abdominal infections (cIAIs) caused by multi-drug-resistant organisms (MDROs) have been identified as being at increased risk for adverse outcomes. Prompt identification and stratification of these patients is essential in the clinical management, allowing the physician timely optimization of empiric antimicrobial therapy while awaiting results of intra-operative cultures to streamline antibiotic treatment. METHODS: The study is a secondary analysis from two prospective multi-center color surveillance studies...
January 3, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29290490/-suboptimal-care-and-severe-bacterial-infection-in-the-french-caribbean-area
#18
E Goisque, E Launay, B Vrignaud, E Jolivet, F Henaff, C Gras-Leguen
OBJECTIVE: To study the frequency and types of suboptimal care in initial management of children suffering from a severe bacterial infection (SBI), in a French region where little is known about pediatric SBI epidemiology. METHOD: Retrospective single-center study over a 6-year period. Children between 3 months and 15 years of age, deceased or surviving and admitted to the pediatric intensive care unit of the university-affiliated hospital of Martinique for a community-onset SBI were included in this study...
December 28, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29288551/comparative-study-of-sequence-aligners-for-detecting-antibiotic-resistance-in-bacterial-metagenomes
#19
Camille McCall, Irene Xagoraraki
We aim to compare the performance of Bowtie2, BWA-MEM, BLASTN, and BLASTX when aligning bacterial metagenomes against the Comprehensive Antibiotic Resistance Database (CARD). Simulated reads were used to evaluate the performance of each aligner under the following four performance criteria: correctly mapped, false positives, multi-reads, and partials. The optimal alignment approach was applied to samples from two wastewater treatment plants to detect ARGs using next generation sequencing. BLASTN mapped with greater accuracy among the four sequence alignment approaches considered followed by Bowtie2...
December 30, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29286572/predicting-bacterial-infections-among-pediatric-cancer-patients-with-febrile-neutropenia-external-validation-of-the-picnicc-model
#20
Rohit P Ojha, Peter H Asdahl, Ewout W Steyerberg, Henrik Schroeder
INTRODUCTION: The Predicting Infectious Complications in Neutropenic Children and Young People with Cancer (PICNICC) model was recently developed for antibiotic stewardship among pediatric cancer patients, but limited information is available about its clinical usefulness. We aimed to assess the performance of the PICNICC model for predicting microbiologically documented bacterial infections among pediatric cancer patients with febrile neutropenia. MATERIALS AND METHODS: We used data for febrile neutropenia episodes at a pediatric cancer center in Aarhus, Denmark between 2000 and 2016...
December 29, 2017: Pediatric Blood & Cancer
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