keyword
MENU ▼
Read by QxMD icon Read
search

suicide burden

keyword
https://www.readbyqxmd.com/read/28081055/state-level-lifetime-medical-and-work-loss-costs-of-fatal-injuries-united-states-2014
#1
Feijun Luo, Curtis Florence
Injury-associated deaths have substantial economic consequences in the United States. The total estimated lifetime medical and work-loss costs associated with fatal injuries in 2013 were $214 billion (1). In 2014, unintentional injury, suicide, and homicide (the fourth, tenth, and seventeenth leading causes of death, respectively) accounted for 194,635 deaths in the United States (2). In 2014, a total of 199,756 fatal injuries occurred in the United States, and the associated lifetime medical and work-loss costs were $227 billion (3)...
January 13, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28073041/major-depressive-disorder-with-subthreshold-hypomanic-mixed-features-a-real-world-assessment-of-treatment-patterns-and-economic-burden
#2
Roger S McIntyre, Daisy Ng-Mak, Chien-Chia Chuang, Rachel Halpern, Pankaj A Patel, Krithika Rajagopalan, Antony Loebel
BACKGROUND: To compare outcomes for individuals with major depressive disorder (MDD) with or without subthreshold hypomania (mixed features) in naturalistic settings. METHODS: Using the Optum Research Database (1/1/2009─10/31/2014), a retrospective analysis of individuals newly diagnosed with MDD was conducted. Continuous enrollment for 12-months before and after the initial MDD diagnosis was required. MDD with subthreshold hypomania (mixed features) (MDD-MF) was defined based on ≥1 hypomania diagnosis within 30 days after an MDD diagnosis during the one-year follow-up period, in the absence of bipolar I diagnoses...
December 23, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28065168/functional-outcomes-of-child-and-adolescent-mental-disorders-current-disorder-most-important-but-psychiatric-history-matters-as-well
#3
J Ormel, A M Oerlemans, D Raven, O M Laceulle, C A Hartman, R Veenstra, F C Verhulst, W Vollebergh, J G M Rosmalen, S A Reijneveld, A J Oldehinkel
BACKGROUND: Various sources indicate that mental disorders are the leading contributor to the burden of disease among youth. An important determinant of functioning is current mental health status. This study investigated whether psychiatric history has additional predictive power when predicting individual differences in functional outcomes. METHOD: We used data from the Dutch TRAILS study in which 1778 youths were followed from pre-adolescence into young adulthood (retention 80%)...
January 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28064358/incipient-progressive-supranuclear-palsy-is-more-common-than-expected-and-may-comprise-clinicopathological-subtypes-a-forensic-autopsy-series
#4
Koji Yoshida, Yukiko Hata, Koshi Kinoshita, Shutaro Takashima, Kortaro Tanaka, Naoki Nishida
We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP...
January 7, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28045465/methylomic-profiling-of-cortex-samples-from-completed-suicide-cases-implicates-a-role-for-psors1c3-in-major-depression-and-suicide
#5
T M Murphy, B Crawford, E L Dempster, E Hannon, J Burrage, G Turecki, Z Kaminsky, J Mill
Major depressive disorder (MDD) represents a major social and economic health issue and constitutes a major risk factor for suicide. The molecular pathology of suicidal depression remains poorly understood, although it has been hypothesised that regulatory genomic processes are involved in the pathology of both MDD and suicidality. In this study, genome-wide patterns of DNA methylation were assessed in depressed suicide completers (n=20) and compared with non-psychiatric, sudden-death controls (n=20) using tissue from two cortical brain regions (Brodmann Area 11 (BA11) and Brodmann Area 25 (BA25))...
January 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#6
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28031587/short-term-cost-of-suicides-in-india
#7
Gopala Sarma Poduri
BACKGROUND: India is experiencing increasing suicides that have much economic impact. OBJECTIVE: To calculate the short-term costs of suicide in India. MATERIALS AND METHODS: All the official data of suicides in India in 2014 formed the base of computation. Both direct and indirect costs were computed basing on market rates and official estimates. Perceived gains were deducted to arrive at the total cost. RESULTS: The contribution of middle age group in the loss was high...
November 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28030616/rare-cnvs-in-suicide-attempt-include-schizophrenia-associated-loci-and-neurodevelopmental-genes-a-pilot-genome-wide-and-family-based-study
#8
Marcus Sokolowski, Jerzy Wasserman, Danuta Wasserman
Suicidal behavior (SB) has a complex etiology involving genes and environment. One of the genetic components in SB could be copy number variations (CNVs), as CNVs are implicated in neurodevelopmental disorders. However, a recently published genome-wide and case-control study did not observe any significant role of CNVs in SB. Here we complemented these initial observations by instead using a family-based trio-sample that is robust to control biases, having severe suicide attempt (SA) in offspring as main outcome (n = 660 trios)...
2016: PloS One
https://www.readbyqxmd.com/read/28009694/can-emergency-department-hospital-discharge-and-death-data-be-used-to-monitor-burden-of-drug-overdose-in-rhode-island
#9
Yongwen Jiang, James V McDonald, Jennifer Koziol, Meghan McCormick, Samara Viner-Brown, Nicole Alexander-Scott
CONTEXT: Drug overdoses are a growing public health problem in the United States. Rhode Island is also confronted with a serious epidemic of drug overdose deaths and ranks sixth worst in the United States for age-adjusted drug overdose death rate. OBJECTIVE: To monitor trends of drug overdose-related emergency department (ED) visits, hospitalizations, and deaths and classify the drug overdoses by demographics, discharge status, intent, and specific drug involved to plan for health care resource allocation, mental health services, drug abuse treatment, prevention, and policies...
December 22, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28005042/-depression-and-epilepsy-comorbidities-pathogenesis-principles-of-therapy
#10
F K Rider, O A Danilenko, M N Grishkina, G V Kustov, R G Akzhigitov, A V Lebedeva, A B Gekht
Numerous trials of last years confirm the bilateral link between depression and epilepsy with mutual complication of both diseases. Depression increases the risk of the first unprovoked paroxysm, worsens the compliance of epileptic patients, leads to decrease of the response both to therapeutic and surgical treatment and to increase of side effects of antiepileptic drugs. Depression is associated with high risk of suicidal behavior and reduces the quality of life level. Depression in epileptic patients is characterized by atypical clinical course in most cases what makes its diagnostics difficult and becomes the reason of the absence of the necessary pharmacologic and psychotherapeutic treatment...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28000377/randomized-controlled-trial-of-a-brief-family-centred-care-programme-for-hospitalized-patients-with-bipolar-disorder-and-their-family-caregivers
#11
Hsiu-Ju Lee, Esther Ching-Lan Lin, Mei-Bih Chen, Tung-Ping Su, Li-Chi Chiang
Family interventions have been emphasized in the treatment of bipolar disorder (BPD) due to the bidirectional and entangled relationships between patients and the family system, and have benefits for patients' symptoms and health; however, the effects of family interventions on family function and caregivers' health-related outcomes have not been well investigated. This randomized, controlled trial with 47 hospitalized patients with BPD/family caregiver dyads at a medical centre in northern Taiwan compared the effects of a brief family-centred care (BFCC) programme with treatment as usual (TAU)...
December 21, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/27993257/-depression-and-anxiety-disorders-and-associated-factors-in-the-adult-colombian-population-2015-national-mental-health-survey
#12
Carlos Gómez-Restrepo, Nathalie Tamayo Martínez, Adriana Bohórquez, Martín Rondón, Mauricio Medina Rico, Hernet Rengifo, Nubia Bautisa
INTRODUCTION: Mental disorders are the first causes of disability adjusted life years (DALY), contributing with the 7.4%. This value increases as the DALYs of the transmittable diseases decrease. OBJECTIVES: To determine the prevalence and associated factors of the major depressive and anxious disorders. METHODS: Data obtained from the IV Mental Health Survey with representation from 5 regions. A computerised interview was conducted, focusing on the most frequent anxiety and depressive disorders, using the CIDI CAPI 3...
December 2016: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/27993256/-depression-and-anxiety-disorders-and-associated-factors-in-the-adolescent-colombian-population-2015-national-mental-health-survey
#13
Carlos Gómez-Restrepo, Adriana Bohórquez, Nathalie Tamayo Martínez, Martín Rondón, Nubia Bautista, Herney Rengifo, Mauricio Medina Rico
INTRODUCTION: There was a prevalence of mental disorders of 17% in adolescents in the past year. These tended to be chronic and their appearance at this age is associated with a worse prognosis than those in adulthood. OBJECTIVES: To determine the prevalence and mental factors associated with major depression and anxiety disorders. METHODS: Data were obtained from the IV National Mental Health Survey representing 5 regions. A structured computerised survey was conducted using the Computer Assisted Personal Interview-Composite International Diagnostic Interview-Adolescent Version (CAPI-CIDI-A), focused on the most common depression and anxiety disorders...
December 2016: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/27992846/suicidal-ideation-and-suicidal-attempts-among-adults-with-chronic-diseases-a-cross-sectional-study
#14
Su-Yeon Kye, Keeho Park
INTRODUCTION: About 14% of the global burden of disease has been attributed to neuropsychiatric disorders. The aim of this study was to show the general picture of suicidal ideation and behavior among Korean, and to test the hypothesis that there is a positive association between diseases and suicidality. METHOD: A total of 19,599 individuals were asked if they had any chronic diseases, suicidal ideation and attempts. The data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V, 2010-2012) conducted by Korea Centers for Disease Control and Prevention (KCDC) were examined...
December 14, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27989927/major-depressive-disorder-among-preadolescent-canadian-children-rare-disorder-or-rarely-detected
#15
Daphne J Korczak, Marianna Ofner, John LeBlanc, Sam Wong, Mark Feldman, Patricia C Parkin
OBJECTIVE: Despite agreement that preadult onset of depression is associated with greater illness severity, and that children can meet the diagnostic criteria for major depressive disorder (MDD), few studies have examined the presentation of MDD among young children. This is the first nationwide study of MDD among preadolescent children in Canada. METHODS: Pediatrician members (2500) of a Canadian pediatric surveillance network were surveyed monthly over 3 years to report new cases of MDD among 5- to 12-year-olds...
December 21, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27988144/counselling-for-alcohol-problems-cap-a-lay-counsellor-delivered-brief-psychological-treatment-for-harmful-drinking-in-men-in-primary-care-in-india-a-randomised-controlled-trial
#16
Abhijit Nadkarni, Benedict Weobong, Helen A Weiss, Jim McCambridge, Bhargav Bhat, Basavaraj Katti, Pratima Murthy, Michael King, David McDaid, A-La Park, G Terence Wilson, Betty Kirkwood, Christopher G Fairburn, Richard Velleman, Vikram Patel
BACKGROUND: Although structured psychological treatments are recommended as first-line interventions for harmful drinking, only a small fraction of people globally receive these treatments because of poor access in routine primary care. We assessed the effectiveness and cost-effectiveness of Counselling for Alcohol Problems (CAP), a brief psychological treatment delivered by lay counsellors to patients with harmful drinking attending routine primary health-care settings. METHODS: In this randomised controlled trial, we recruited male harmful drinkers defined by an Alcohol Use Disorders Identification Test (AUDIT) score of 12-19 who were aged 18-65 years from ten primary health centres in Goa, India...
December 14, 2016: Lancet
https://www.readbyqxmd.com/read/27966011/-factors-which-influence-the-position-towards-euthanasia-results-of-a%C3%A2-representative-survey-among-older-people-in-germany
#17
Mathias Roesinger, Laura Prudlik, Sara Pauli, Ingrid Hendlmeier, Alexander Noyon, Martina Schäufele
BACKGROUND: Until now older adults have not been a target group for surveys regarding their personal attitudes towards euthanasia, although they are closest to chronic illness and death. OBJECTIVE: To determine the attitudes of older adults towards euthanasia and controversial topics in the context of illness, euthanasia and care (e. g. palliative care) on the basis of a representative sample. MATERIAL AND METHODS: The study was based on a postal survey of a representative random sample of the population aged 65 years and older (n = 3500) from a city in southern Germany using a standardized questionnaire...
December 13, 2016: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/27940914/alterations-in-the-neuropeptide-galanin-system-in-major-depressive-disorder-involve-levels-of-transcripts-methylation-and-peptide
#18
Swapnali Barde, Joelle Rüegg, Josée Prud'homme, Tomas J Ekström, Miklos Palkovits, Gustavo Turecki, Gyorgy Bagdy, Robert Ihnatko, Elvar Theodorsson, Gabriella Juhasz, Rochellys Diaz-Heijtz, Naguib Mechawar, Tomas G M Hökfelt
Major depressive disorder (MDD) is a substantial burden to patients, families, and society, but many patients cannot be treated adequately. Rodent experiments suggest that the neuropeptide galanin (GAL) and its three G protein-coupled receptors, GAL1-3, are involved in mood regulation. To explore the translational potential of these results, we assessed the transcript levels (by quantitative PCR), DNA methylation status (by bisulfite pyrosequencing), and GAL peptide by RIA of the GAL system in postmortem brains from depressed persons who had committed suicide and controls...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27940416/social-anxiety-and-suicidal-ideation-test-of-the-utility-of-the-interpersonal-psychological-theory-of-suicide
#19
Julia D Buckner, Austin W Lemke, Emily R Jeffries, Sonia M Shah
Social anxiety is related to greater suicidality, even after controlling for depression and other psychopathology. The Interpersonal-Psychological Theory of Suicide (IPTS; Joiner, 2005) proposes that people are vulnerable to wanting to die by suicide if they experience both perceived burdensomeness (sense that one is a burden to others) and thwarted belongingness (a greater sense of alienation from others). Socially anxious persons may be especially vulnerable to these interpersonal factors. The current study tested whether interpersonal IPTS components independently and additively mediate the social anxiety-suicidal ideation (SI) relation among 780 (80...
January 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27940233/protective-immune-response-in-mice-induced-by-a-suicidal-dna-vaccine-encoding-ntpase-ii-gene-of-toxoplasma-gondii
#20
Lina Zheng, Yue Hu, Qianqian Hua, Fangjun Luo, Guizhen Xie, Xiangzhi Li, Jiaxin Lin, Yujing Wan, Shoufeng Ren, Changwang Pan, Feng Tan
DNA-based alphaviral RNA replicon vectors, also called suicidal DNA vectors, have been employed to alleviate biosafety concerns attribution to its ability to induce apoptotic cell death of the transfected cells. Toxoplasma gondii nucleoside triphosphate hydrolase-II (TgNTPase-II), which facilitates the parasite to salvage purines from the host cell for survival and replication, have been demonstrated to be a potential vaccine candidate for toxoplasmosis. Herein, we evaluated the immunogenic potential of a suicidal DNA vaccine encoding TgNTPase-II gene, pDREP-TgNTPase-II, delivered intramuscularly in combination with electroporation...
February 2017: Acta Tropica
keyword
keyword
115923
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"