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ceus and radiotherapy

M Apfelbeck, D-A Clevert, J Ricke, C Stief, B Schlenker
INTRODUCTION: Reduced acceptance of radical prostatectomy in patients with low risk or intermediate risk prostate cancer has significantly changed treatment strategies in prostate cancer (PCa) during the last years. Focal therapy of the prostate with high intensity focused ultrasound (HIFU) is an organ-preserving treatment for prostate cancer with less impairment of health-related quality of life. Follow-up after HIFU therapy by imaging modalities remains a major problem as eg. MRI performs poorly...
2018: Clinical Hemorheology and Microcirculation
Pietro Ghedini, I Bossert, L Zanoni, F Ceci, T Graziani, P Castellucci, V Ambrosini, F Massari, E Nobili, B Melotti, A Musto, S Zoboli, L Antunovic, M Kirienko, A Chiti, C Mosconi, A Ardizzoni, R Golfieri, S Fanti, C Nanni
AIM: During our daily clinical practice using 11C-Choline PET/CT for restaging patients affected by relapsing prostate cancer (rPCa) we noticed an unusual but significant occurrence of hypodense hepatic lesions with a different tracer uptake. Thus, we decided to evaluate the possible correlation between rPCa and these lesions as possible hepatic metastases. MATERIALS AND METHODS: We retrospectively enrolled 542 patients diagnosed with rPCa in biochemical relapse after a radical treatment (surgery and/or radiotherapy)...
May 2018: European Journal of Nuclear Medicine and Molecular Imaging
Dorothy M Gujral, Wing Keung Cheung, Benoy N Shah, Navtej S Chahal, Sanjeev Bhattacharyya, James Hooper, Roxy Senior, Meng-Xing Tang, Kevin J Harrington, Christopher M Nutting
PURPOSE: Abnormal proliferation of adventitial vasa vasorum (vv) occurs early at sites of atherosclerosis and is thought to be an early biomarker of vascular damage. Contrast-enhanced ultrasound (CEUS) can detect this process. Its usefulness in irradiated arteries as a measure of accelerated atherosclerosis is unknown. This study investigates contrast intensity in carotid adventitia as an early marker of radiation-induced damage in head and neck cancer (HNC) patients. MATERIALS/METHODS: Patients with HNC treated with a wedged-pair and matched neck technique or hemi-neck radiotherapy (RT) (unirradiated side as control) at least 2years previously were included...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Chen Yang, Dong-Hoon Lee, Antonella Mangraviti, Lin Su, Kai Zhang, Yin Zhang, Bin Zhang, Wenxiao Li, Betty Tyler, John Wong, Ken Kang-Hsin Wang, Esteban Velarde, Jinyuan Zhou, Kai Ding
PURPOSE: Radiotherapy remains a major treatment method for malignant tumors. Magnetic resonance imaging (MRI) is the standard modality for assessing glioma treatment response in the clinic. Compared to MRI, ultrasound imaging is low-cost and portable and can be used during intraoperative procedures. The purpose of this study was to quantitatively compare contrast-enhanced ultrasound (CEUS) imaging and MRI of irradiated gliomas in rats and to determine which quantitative ultrasound imaging parameters can be used for the assessment of early response to radiation in glioma...
August 2015: Medical Physics
Zhimin Ye, Pintong Huang, Xiaofeng Zhou, Qian Huang, Qiongge Hu, Yongjie Shui, Li Shen, Enyin Lai, Qichun Wei
Nasopharyngeal carcinoma (NPC) is a common type of cancer in South East Asia with peculiar epidemiology, pathology, clinical behavior and response to treatment characteristics. To the best of our knowledge, this is the first study to investigate the use of a contrast-enhanced ultrasound (CEUS) as a predictor for the therapeutic response in lymph node metastases of NPC patients treated with radiation-based therapy. Sixty-seven NPC patients with lymph node metastases underwent the lymph nodes CEUS examination twice; pre- and in-treatment (at the 5th fraction radiotherapy), respectively...
September 2014: Molecular and Clinical Oncology
Roxy Senior, Dorothy M Gujral, Navtej S Chahal, Kevin J Harrington, Christopher M Nutting, Benoy Shah
BACKGROUND: Irradiation of the carotid artery during radiotherapy (RT) for head/neck cancer (HNC) increases intima-media thickness, plaque formation and risk of stroke. However, the effects of RT on plaque composition are unknown. Intraplaque neovascularization (IPN) is a precursor to intraplaque haemorrhage and thus considered to be a marker of plaque instability. Contrast-enhanced ultrasound (CEUS) is a novel method of indirectlyassessing plaque vulnerability by detection of IPN. METHODS: B-mode and CEUS carotid ultrasonography were performed in survivors of HNC who had received RT >2 yrs previously and had received >50Gy dose to the ipsilateral neck...
June 2014: Heart: Official Journal of the British Cardiac Society
Bradley Pieters, Hessel Wijkstra, Marcel van Herk, Ruud Kuipers, Emmie Kaljouw, Jean de la Rosette, Caro Koning
PURPOSE: To investigate the possibility of localization of intraprostatic lesions (IL) with contrast-enhanced ultrasound (CEUS) to support the brachytherapy treatment planning of temporary implants. MATERIAL AND METHODS: Two brachytherapy treatment plans were generated for 8 patients treated with external beam radiotherapy and pulsed-dose rate brachytherapy boost for prostate cancer. The first and second brachytherapy treatment plan was without and with knowledge of the localization of the ILs, respectively...
June 2012: Journal of Contemporary Brachytherapy
Caroline Ewertsen
The aim of this thesis was to test the clinical application of image fusion involving US. The first study describes the accuracies of different methods of co-registration in a phantom. The accuracy improved if co-registration was made from points or planes close to the area examined. The second study describes the accuracy of image-guided intervention on structures invisible to US but visible to CT or MRI. We measured a rate of success of biopsies in a phantom and found a rate of success, similar to that of conventional US-guided biopsy...
September 2010: Danish Medical Bulletin
Martin Krix
Ultrasound techniques are presented using the contrast agent SonoVue (Bracco, Italy) for microvascular imaging of liver metastases and for the detection of treatment-related changes in tumour perfusion. Technical requirements and examination protocols for contrast-enhanced ultrasound (CEUS) in the detection of microvascularity are described. Procedures for the quantitative analysis of perfusion in follow-up examinations are explained. Compared to contrast-enhanced computed tomography, low-MI (mechanical index) CEUS with SonoVue better reflected the arterial perfusion of liver metastases...
December 2005: European Radiology
M Krix, C Plathow, M Essig, K Herfarth, J Debus, H-U Kauczor, S Delorme
The purpose of this study was to monitor liver metastases after radiotherapy using contrast-enhanced ultrasound (CEUS). In 15 patients, follow-up examinations after stereotactic, single-dose radiotherapy were performed using CEUS (low mechanical index (MI), 2.4-ml SonoVue) and computed tomography (CT). Besides tumor size, the enhancement of the liver and the metastases was assessed at the arterial, portal venous, and delayed phases. The sizes of the tumor and of a perifocal liver reaction after radiotherapy measured with CEUS significantly correlated with those measured at CT (r=0...
April 2005: European Radiology
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