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C Isbert
The Contour® Transtar™ operation represents a further methodological development of conventional transanal stapled rectal resection (STARR) for the treatment of obstructed defecation syndrome (ODS) and/or full thickness rectal prolapse. In contrast to the conventional STARR technique a specially designed single curved stapler is used with which the rectal wall is incised in a circular fashion and anastomosed. This results in a monoblock resection with almost unlimited extent of resection. In multicenter studies the procedure has generally been shown to be effective for treatment of ODS with intussusception and rectocele...
October 14, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Yuuta Horioka, Ryuki Kusumoto, Kengo Yamane, Ryosuke Nomura, Takeshi Hirokawa, Kazuaki Ito
A fast and sensitive ion chromatographic method for the simultaneous determinations of six inorganic anions [iodate (IO3(-)), bromate (BrO3(-)), bromide (Br(-)), nitrite (NO2(-)), nitrate (NO3(-)), and iodide (I(-))] in seawater is described using dodecylammonium (DA(+))-coated monolithic octadecylsilyl (ODS) columns, a concentrated aqueous NaCl mobile phase containing dodecylammonium chloride (DAC), and a UV detector. The DA(+)-coated monolithic ODS columns show greater retention for iodate and weaker retention for iodide, compared to dilauryldimethylammonium (DDA(+))-coated monolithic ODS columns...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Samah A Mohammed, Maya S Eissa, Hytham M Ahmed
Fast and sensitive HPLC method was developed, optimized and validated for quantification of linezolid (LNZ) in human plasma using guaifenesin as an internal standard (IS). Analyte and IS were extracted from plasma by simple protein precipitation extraction technique using methanol as the precipitating solvent. The pretreated samples were injected in a mobile phase formed of acetonitrile:water:methanol (20:70:10v/v/v) in an isocratic mode at a flow rate of 1.5mL/min with UV detection at 251nm. Separation was done using Aglient ODS C18...
October 3, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Michael Pt Lunn, Eduardo Nobile-Orazio
BACKGROUND: Serum monoclonal anti-myelin-associated glycoprotein (anti-MAG) antibodies may be pathogenic in some people with immunoglobulin M (IgM) paraprotein and demyelinating neuropathy. Immunotherapies aimed at reducing the level of these antibodies might be expected to be beneficial. This is an update of a review first published in 2003 and previously updated in 2006 and 2012. OBJECTIVES: To assess the effects of immunotherapy for IgM anti-MAG paraprotein-associated demyelinating peripheral neuropathy...
October 4, 2016: Cochrane Database of Systematic Reviews
Joseph A Boscarino, H Lester Kirchner, James M Pitcavage, Vijay R Nadipelli, Naoko A Ronquest, Michael H Fitzpatrick, John J Han
OBJECTIVE: Opioid overdoses (ODs) have been increasing, and harm reduction efforts are a priority. The success of these efforts will be dependent on the identification of at-risk patients and improved access to the antidote naloxone. Therefore, to identify access to naloxone and factors associated with negative health outcomes, we conducted a retrospective study of patients with OD to identify those at highest risk of adverse outcomes and to assess the use of naloxone. METHODS: We conducted a study of electronic health records for patients admitted to the largest multihospital system in the region - the Geisinger Health System (GHS) for ODs - from April 2005 through March 2015...
2016: Substance Abuse and Rehabilitation
Wei-Cheng Liu, Song-Lin Wan, S M Yaseen, Xiang-Hai Ren, Cui-Ping Tian, Zhao Ding, Ken-Yan Zheng, Yun-Hua Wu, Cong-Qing Jiang, Qun Qian
Obstructed defecation syndrome (ODS) is a functional disorder commonly encountered by colorectal surgeons and gastroenterologists, and greatly affects the quality of life of patients from both societal and psychological aspects. The underlying anatomical and pathophysiological changes of ODS are complex. However, intra-rectal intussusception and rectocele are frequently found in patients with ODS and both are thought to play an important role in the pathogenesis of ODS. With the development of evaluation methods in anorectal physiology laboratories and radiology studies, a great variety of new operative procedures, especially transanal procedures, have been invented to treat ODS...
September 21, 2016: World Journal of Gastroenterology: WJG
Xingling Ma, Wentao Zhou, Qiaogen Zou, Pingkai Ouyang
As the first approved androgen receptor(AR) signalling inhibitor, Enzalutamide was approved by the US Food and Drug Administration as an anticancer drug used to treat castration-resistant prostate cancer in 2012. In this manuscript, six potential impurities of Enzalutamide including process impurities and degradation products were studied. The structures of six impurities obtained by synthesis were characterized and confirmed by IR, NMR and MS techniques. In addition, an efficient chromatographic method to separate and quantify these impurities was developed, which achieved on Inertsil ODS-3 column (250mm×4...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
Michele M Schantz, Carissa D Powers, Rosemary L Schleicher, Joseph M Betz, Stephen A Wise
BACKGROUND: There are a large number of clinical studies focusing on the measurement of individual fatty acids in serum or plasma; however, few studies have focused on the interlaboratory comparisons of these measurements. The National Institutes of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements (NIH-ODS) and the Centers for Disease Control and Prevention (CDC), has initiated a quality assurance program for assessing and improving the comparability of individual fatty acid measurements in serum and plasma...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Xi Chen, Bei Xu, Jian Yang, Juan Liu, Dailong Fang, Yongjun Gu, Zhifei Jian, Minghai Tang, Chunmei Fu, Zhi Zhang, Chunling Jiang, Xiangrong Song
To investigate the pharmacokinetic (PK) interaction between telmisartan (Tel) and pitavastatin (Pit), a rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometric assay method had been successfully established and fully validated for the simultaneous quantification of Tel and Pit in rat plasma. A simple protein precipitation procedure was adopted for the sample preparation with satisfactory extraction recovery for both analytes and the internal standard. The samples were chromatographed on an Inertsil ODS-3 C18 column (100mm×2...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
Francisco Pérez Bartolomé, Jose María Martínez de la Casa, Irene Camacho Bosca, Federico Sáenz-Francés, Soledad Aguilar Munoa, Alberto Martín Juan, Julian Garcia-Feijoo
PURPOSE: To examine interrelations between corneal biomechanics, ocular biometric variables and optic disc size (ODS), lamina cribosa depth (LCD) or thickness (LCT) in a healthy population. MATERIAL AND METHODS: In a cross-sectional case-control study, the following measurements were made in 81 eyes of 81 participants: axial length, anterior chamber depth, lens thickness, and central corneal thickness using the optical biometer Lenstar LS900; and corneal hysteresis (CH), corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) using the Ocular Response Analyzer...
September 14, 2016: Seminars in Ophthalmology
Andras Farkas, Gergely Daroczi, Phillip Villasurda, Michael Dolton, Midori Nakagaki, Jason A Roberts
Bayesian methods for voriconazole therapeutic drug monitoring (TDM) have been reported previously but there are only sparse reports comparing the accuracy and precision of predictions of published models. Furthermore, the comparative accuracy of linear, mixed linear and non-linear, or entirely nonlinear models may be of high clinical relevance. In this study, models were coded into Individually Designed Optimum Dosing Strategies (ID-ODS™) with voriconazole concentration data analyzed using inverse Bayesian modeling...
September 6, 2016: Antimicrobial Agents and Chemotherapy
Mathias Kranz, Bernhard Sattler, Nathanael Wüst, Winnie Deuther-Conrad, Marianne Patt, Philipp M Meyer, Steffen Fischer, Cornelius K Donat, Bernhard Wünsch, Swen Hesse, Jörg Steinbach, Peter Brust, Osama Sabri
The enantiomers of [(18)F]fluspidine, recently developed for imaging of σ₁ receptors, possess distinct pharmacokinetics facilitating their use in different clinical settings. To support their translational potential, we estimated the human radiation dose of (S)-(-)-[(18)F]fluspidine and (R)-(+)-[(18)F]fluspidine from ex vivo biodistribution and PET/MRI data in mice after extrapolation to the human scale. In addition, we validated the preclinical results by performing a first-in-human PET/CT study using (S)-(-)-[(18)F]fluspidine...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jae-Woo Jung, Ji-Hae Park, Yeong-Geun Lee, Kyeong-Hwa Seo, Eun-Ji Oh, Dae-Young Lee, Dong-Wook Lim, Daeseok Han, Nam-In Baek
Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a₇ (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO₂), octadecyl SiO₂ (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M M Tolba, F Belal
A study of the performance of reversed-phase chromatography with a programmable multiwavelength fluorimetric technique using either conventional hydro-organic or micellar eluent is established for the determination of xipamide (XIP) in the presence of its degradation product, 2,6-xylidine (XY). In conventional liquid chromatography (CLC), the analyses were carried out on a Promosil ODS 100 Å column (250 mm × 4.6 mm i.d., 5 μm) using a mobile phase consisting of methanol/0.1 M phosphate buffer (65: 35, v/v) at pH 4...
August 26, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
Jae Won Lee, Hyun Ki Kim, Yong Sik Woo, Jaehoon Jahng, Young Ran Jin, Jong Heon Park, Yong Sung Kim, Hwoon Yong Jung
BACKGROUND/AIMS: Peptic ulcer bleeding (PUB) is the most common cause of upper gastrointestinal bleeding in Korea but there has been no research done using big data. This study evaluates the optimal operational definition (OD) for big data research by analyzing clinical characteristics of PUB. METHODS: We reviewed the clinical characteristics of 92 patients with PUB confirmed on endoscopy in Wonkwang University Sanbon Hospital (January 2013 to December 2014). We calculated sensitivity and positive predictive value (PPV) to detect confirmed PUB patients using ODs developed by combining clinical features of patients with PUB...
August 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
O Schwandner, P Hillemanns
Rectal intussusception and ventral rectocele are frequent morphological findings in patients suffering from obstructed defecation syndrome (ODS). After failed conservative treatment a surgical option can be discussed. Surgical approaches include the stapled transanal rectal resection (STARR) procedure, which is performed as a transanal approach by using two circular (PPH01) staplers for ventral and dorsal full-thickness resection of the distal rectum. Both retrospective and prospective studies as well as data from the German STARR registry demonstrated that the STARR procedure is safe and effective for symptom improvement and resolution in ODS associated with rectal intussusception in the short-term; however, disappointing functional results, particularly related to fecal incontinence and urgency, severe complications and high rates of revision surgery have also been documented...
August 17, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Abby G Ershow, Gay Goodman, Paul M Coates, Christine A Swanson
The NIH Office of Dietary Supplements (ODS) convened 3 workshops on iodine nutrition in 2014, each held in Rockville, Maryland. These workshops were part of the ongoing ODS Iodine Initiative, begun in 2011 in response to concerns that US pregnant women may be at risk of iodine deficiency and that a high fraction of prenatal dietary supplements do not contain the recommended amounts of iodine. The primary purpose of the workshops was to consider the data and resources necessary to evaluate the clinical and public health benefits and risks of maternal iodine supplementation in the United States...
September 2016: American Journal of Clinical Nutrition
Dimitrina Zheleva-Dimitrova, Paraskev Nedialkov, Ulrich Giresser
A HPLC-UV method for analysis of the main compounds: caffeoyl phenylethanoid glucosides myconoside (1) and paucifloside (2) and flavone 8-C-glycosides: hispidulin 8-C-β-galactopyranoside (3), hispidulin 8-C-(2"-O-syringoyl-β-glucopyranoside) (4), hispidulin 8-C-(6-O-acetyl-β-glucopyranoside) (5) and hispidulin 8-C-(6-O-acetyl-2"-O-syringoyl--glucopyranoside) (6) in Haberlea rhodopensis leaves was developed and validated. Compound 3 was isolated for the first time from the title species. Ultrasound extraction with 80% methanol at room temperature allowed a good recovery of analytes (from 87...
June 2016: Natural Product Communications
John J Veillette, S Alexander Winans, Steven C Forland, Victoria K Maskiewicz
A rapid and sensitive reverse phase HPLC (RP-HPLC) method for the simultaneous quantitation of piperacillin and tazobactam in human plasma has been developed and validated. The method utilizes a novel, simple and rapid solid phase extraction step, which results in an improved extraction yield of analytes from human plasma, as well as significantly reduced interference from serum components at low UV wavelength detection compared to previously published liquid-liquid extraction methods. Chromatographic separation was carried out on a Hypersil ODS C18, 3μm column using an acetonitrile-trifluoroacetic acid-water gradient elution with dual wavelength quantitation at 254nm for piperacillin and 218nm for tazobactam...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
F C Phillips, W L Erdahl, J D Nadenicek, L J Nutter, J A Schmit, O S Privett
The analysis of triglyceride species by high performance liquid chromatography (HPLC) with a flame ionization detector (FID) and reversed-phase chromatography using chemically bonded octadecyl silane (ODS) Zorbax columns and gradient or isocratic solvent elution with methylene chloride/acetonitrile is described. Triglycerides containing acyl groups of critical pairs,trans and positional isomers, as well as mixtures of even and odd chain lengths are separated. Identification of triglycerides is made on the basis of retention times compared with equivalent and theoretical carbon numbers, and comparison with chromatograms of reference triglyceride mixtures...
February 1984: Lipids
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