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https://www.readbyqxmd.com/read/28740446/diffusion-kurtosis-imaging-of-gliomas-grades-ii-and-iii-a-study-of-perilesional-tumor-infiltration-tumor-grades-and-subtypes-at-clinical-presentation
#1
Anna F Delgado, Markus Fahlström, Markus Nilsson, Shala G Berntsson, Maria Zetterling, Sylwia Libard, Irina Alafuzoff, Danielle van Westen, Jimmy Lätt, Anja Smits, Elna-Marie Larsson
BACKGROUND: Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was to investigate if diffusion parameters in the perilesional normal-appearing white matter (NAWM) differed from contralesional white matter, and to investigate differences between glioma malignancy grades II and III and glioma subtypes (astrocytomas and oligodendrogliomas)...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28719037/efficient-separation-of-high-purity-compounds-from-oxytropis-falcata-using-two-dimensional-preparative-chromatography
#2
Weidong Wang, Yanduo Tao, Lijin Jiao, Minxia Fan, Yun Shao, Qilan Wang, Lijuan Mei, Jun Dang
The separation of high-purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate compounds with high purity because of the complexity of traditional Tibetan medicines. In this work, an offline two-dimensional reversed-phase preparative method was successfully developed for the separation of high-purity compounds from Oxytropis falcata. Based on the analysis results, an ODS C18 prep column was used for first-dimensional preparation, and 14...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28707762/pharmacokinetics-and-tissue-distribution-study-of-clevidipine-and-its-primary-metabolite-h152-81-in-rats
#3
Yan Wang, Lanting Zhao, Tengfei Li, Wen Yang, Qian Li, Luning Sun, Li Ding
This present study was designed to investigate the pharmacokinetic profiles and tissue distribution characteristics of clevidipine and its primary metabolite H152/81 in rats following a single intravenous administration of clevidipine butyrate injectable emulsion (CBIE). For this study, a sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established and validated for the simultaneous quantitation of clevidipine and H152/81 in rat whole blood and various tissues. A Hedera ODS-2 column with two gradient elution programs was employed for the troubleshooting of matrix effect on the detection of analytes among different biological samples...
July 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28704725/simultaneous-estimation-of-lisofylline-and-pentoxifylline-in-rat-plasma-by-high-performance-liquid-chromatography-photodiode-array-detector-and-its-application-to-pharmacokinetics-in-rat
#4
Kishan S Italiya, Saurabh Sharma, Ishit Kothari, Deepak Chitkara, Anupama Mittal
Lisofylline (LSF) is an anti-inflammatory and immunomodulatory agent with proven activity in serious infections associated with cancer chemotherapy, hyperoxia-induced acute lung injury, autoimmune disorders including type-1 diabetes (T1DM) and islet rejection after islet transplantation. It is also an active metabolite of another anti-inflammatory agent, Pentoxifylline (PTX). LSF bears immense therapeutic potential in multiple pharmacological activities and hence appropriate and accurate quantification of LSF is very important...
June 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28693959/value-and-limits-of-stapled-transanal-rectal-repair-for-obstructed-defecation-syndrome-10-years-experience-with-450-cases
#5
Angelo Guttadauro, Marco Chiarelli, Matteo Maternini, Melissa Baini, Nicoletta Pecora, Francesco Gabrielli
BACKGROUND/OBJECTIVE: In the late's 90' a new surgical treatment, the stapled trans-anal rectal resection (STARR) was born to treat obstructed defecation syndrome (ODS). In this study we retrospectively analyze a series of 450 cases that underwent STARR in 10 years. METHODS: Between January 2001 to December 2011, 450 patients, diagnosed with ODS syndrome caused by rectocele or intussusception, underwent to STARR procedure. The presence of rectocele and/or intussusception was verified by dynamic defecography...
July 7, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28676882/dermoscopy-digital-dermoscopy-and-other-diagnostic-tools-in-the-early-detection-of-melanoma-and-follow-up-of-high-risk-skin-cancer-patients
#6
Luc Thomas, Susana Puig
Early detection is a key strategy for reducing the mortality and economic burden associated with melanoma. Dermoscopy is a non-invasive and cost-effective tool for melanoma diagnosis, which has been shown to be a reliable and sensitive method for detecting early-stage skin cancer and reducing the number of unnecessary excisions. Patients at high risk of developing melanoma require long-term surveillance. Use of digital dermoscopy follow-up of these patients has led to improved outcomes. Combined follow-up programmes using total-body photography and digital dermoscopy have led to further improvements in early diagnosis and diagnostic accuracy...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28661609/-estimation-of-bilio-oigestive-and-interintestinal-anastomoses-formed-in-accordance-to-method-of-a-high-frequency-electric-welding-of-tissues-in-experiment
#7
A I Hutsuliak
In the experiment on 50 rabbits cholecysto-entero and entero-entero anastomoses were formed on intestinal Roux loop. In 35 animals (the main group) a single layer evert- ing anastomoses by using high frequence (HF) electric welding method were formed, in 15 (the comparison group) single row suture anastomoses has been done. The anas- tomosis sufficiency were performed by using hydropressure, pneumopressure meth- ods and breakload test. It was established that all anastomoses formed by HF-electric welding method were passable and hermetic, also had strong sufficiency...
August 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/28660092/novel-hplc-analysis-of-hydrocortisone-in-conventional-and-controlled-release-pharmaceutical-preparations
#8
Ofosua Adi-Dako, Samuel Oppong Bekoe, Kwabena Ofori-Kwakye, Enoch Appiah, Paul Peprah
An isocratic sensitive and precise reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination and quantification of hydrocortisone in controlled-release and conventional (tablets and injections) pharmaceutical preparations. Chromatographic separation was achieved on an ODS (C18), 5 μm, 4.6 × 150 mm, with an isocratic elution using a freshly prepared mobile phase of composition methanol : water : acetic acid (60 : 30 : 10, v/v/v) at a flow rate of 1...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28654786/l-proline-based-deep-eutectic-solvents-dess-for-deep-catalytic-oxidative-desulfurization-ods-of-diesel
#9
Lingwan Hao, Meiri Wang, Wenjuan Shan, Changliang Deng, Wanzhong Ren, Zhouzhou Shi, Hongying Lü
A series of L-proline-based DESs was prepared through an atom economic reaction between L-proline (L-Pro) and four different kinds of organic acids. The DESs were characterized by Fourier transform infrared spectroscopy (FT-IR), H nuclear magnetic resonance ((1)HNMR), cyclic voltammogram (CV) and the Hammett method. The synthesized DESs were used for the oxidative desulfurization and the L-Pro/p-toluenesultonic acid (L-Pro/p-TsOH) system shows the highest catalytic activity that the removal of dibenzothiophene (DBT) reached 99% at 60°C in 2h, which may involve the dual activation of the L-Pro/p-TsOH...
June 21, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28652787/oncology-drugs-for-orphan-indications-how-are-hta-processes-evolving-for-this-specific-drug-category
#10
REVIEW
Elizabeth M Adkins, Lindsay Nicholson, David Floyd, Mark Ratcliffe, Helene Chevrou-Severac
Orphan drugs (ODs) are intended for the diagnosis, prevention, or treatment of rare diseases. Many cancer subtypes, including all childhood cancers, are defined as rare diseases, and over one-third of ODs are now intended to treat oncology indications. However, market access for oncology ODs is becoming increasingly challenging; ODs are prone to significant uncertainty around their cost-effectiveness, while payers must balance the need for these vital innovations with growing sensitivity to rising costs. The objective of this review was to evaluate different mechanisms that have been introduced to facilitate patient access to oncology ODs in five different countries (Australia, Canada, England, France, and Sweden), using eight oncology ODs and non-orphan oncology drugs as examples of their application...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28629537/triterpenoid-saponins-from-the-roots-of-cyathula-officinalis-and-their-inhibitory-effects-on-nitric-oxide-production
#11
Yun-Tao Jiang, Wen-Jing Yan, Chu-Lu Qi, Ji-Qin Hou, Yan-Ying Zhong, Hui-Jun Li, Hao Wang, Ping Li
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl-(1→3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28623867/a-validated-uhplc-ms-ms-method-for-the-measurement-of-riluzole-in-plasma-and-myocardial-tissue-samples
#12
Suzanne L Parker, Yarmarly C Guerra Valero, Jeffrey Lipman, Steven Weiss, Camilla Smith, Lyndal Russell, Paul Smith, Jason A Roberts, Steven C Wallis
Through blocking the cardiac persistent sodium current, riluzole has the potential to prevent myocardial damage post cardiac bypass surgery. A sensitive UHPLC-MS/MS method was developed and validated for quantitation of riluzole and 5-methoxypsoralen in human plasma and myocardial tissue homogenate using a liquid-liquid extraction with dichloromethane. The chromatographic separation was achieved using Shimadzu Shim-pack XR-ODS III, 2.0 x 50 mm, 1.6 μm column with a gradient mobile phase comprising of methanol and ammonium acetate buffer pH 3...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28623864/a-highly-sensitive-lc-ms-ms-method-for-simultaneous-determination-of-glycyrrhizin-and-its-active-metabolite-glycyrrhetinic-acid-application-to-a-human-pharmacokinetic-study-after-oral-administration
#13
Tsuneharu Suzuki, Michiko Tsukahara, Yuko Akasaka, Hideo Inoue
A highly sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of glycyrrhizin (GL) and its active metabolite, glycyrrhetinic acid (GA) from human plasma was validated and applied to a human pharmacokinetic study. The analytes were extracted from human plasma using an Oasis MAX cartridge and chromatographic separation was performed on an Inertsil ODS-3 column. The detection was performed using an API 4000 mass spectrometer operating in the positive electrospray ionization mode...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28620705/topical-bevacizumab-treatment-in-aniridia
#14
Ruth Lapid-Gortzak, Nathalie T Y Santana, Carla P Nieuwendaal, Maarten P Mourits, Ivanka J E van der Meulen
PURPOSE: To report the results of long-term topical treatment with bevacizumab (Avastin) 5 mg/mL eyedrops in a case of aniridia-related neovacularization of the cornea. METHODS: Interventional case report. A female patient with aniridia had a decrease in the best corrected visual acuity from 0.32 to 0.02 in the OS over the course of 4 years, secondary to central corneal neovascularization and epithelial breakdown. Vision in the OD was 0.2. In 2008, at age 28, a shared decision was made to start off-label treatment with bevacizumab eyedrops 0...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28613841/estimating-a-representative-value-and-proportion-of-true-zeros-for-censored-analytical-data-with-applications-to-contaminated-site-assessment
#15
Claus P Haslauer, Jessica R Meyer, András Bárdossy, Beth L Parker
This paper demonstrates a maximum likelihood (ML)-based approach to derive representative ("best guess") contaminant concentrations from data with censored values (e.g., less than the detection limit). The method represents an advancement over existing techniques because it is capable of estimating the proportion of measurements that are true zeros and incorporating varying levels of censorship (e.g., sample specific detection limits, changes through time in method detection). The ability of the method to estimate the proportion of true zeros is validated using precipitation data...
June 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28600694/starr-with-contour-transtar-for-obstructed-defecation-syndrome-long-term-results
#16
Francesco Saverio Mari, Massimo Pezzatini, Marcello Gasparrini, Brescia Antonio
INTRODUCTION: Obstructed defecation syndrome (ODS) is a widespread and disabling syndrome. With this study, we want to evaluate the long-term results of stapled transanal rectal resection (STARR) performed with Contour Transtar device in the treatment for ODS. A re-evaluation of 113 patients subjected to STARR from June 2007 to January 2010 was conducted. METHODS: All the patients treated for symptomatic ODS with STARR with Contour Transtar were included in the study...
June 9, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28592800/paradoxical-puborectalis-syndrome-on-diffusion-weighted-imaging-a-retrospective-study-of-72-cases
#17
Guiqin Liu, Zhe Cui, Yongming Dai, Qiuying Yao, Jianrong Xu, Guangyu Wu
This study aimed to evaluate the application value of diffusion-weighted imaging (DWI) for assessing paradoxical puborectalis syndrome (PPS) in patients with obstructive defecation syndrome (ODS). The medical records of 72 ODS patients who underwent magnetic resonance (MR)-DWI and MR-defecography were retrospectively reviewed. The differences in the apparent diffusion coefficients (ADCs) and the thickness of the right and left branches of the puborectalis muscles between the PPS(+) and PPS(-) groups were compared...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28580758/nuclei-specific-deposits-of-iron-and-calcium-in-the-rat-thalamus-after-status-epilepticus-revealed-with-quantitative-susceptibility-mapping-qsm
#18
Manisha Aggarwal, Xu Li, Olli Gröhn, Alejandra Sierra
PURPOSE: To investigate pathological changes in the rat brain after pilocarpine-induced status epilepticus using quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: 3D multiecho gradient-echo (GRE) data were acquired from ex vivo brains of pilocarpine-injected and age-matched control rats at 11.7T. Maps of R2* and quantitative susceptibility were calculated from the acquired 3D GRE magnitude and phase data, respectively. QSM and R2* maps were compared with Perls' (iron) and Alizarin-red-S (calcium) stainings in the same brains to investigate the pathophysiological basis of susceptibility contrast...
June 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28577170/laparoscopic-ventral-mesh-rectopexy-for-obstructive-defecation-syndrome-still-the-way-to-go
#19
Stefan Riss, Joseph Winstanley, Mhairi Collie
Laparoscopic ventral mesh rectopexy (VMR) has become a popular surgical technique for treating women with full-thickness rectal prolapse with a low recurrence rate, as demonstrated by several studies. In addition, it is increasingly applied to female patients with obstructive defecation syndrome (ODS) caused by intussusception ± rectocele. Functional improvement can be achieved in a high number of patients with ODS, but expectations need to be discussed carefully, as a few patients may not benefit at all. In particular, long-term data on functional outcome and complications following laparoscopic VMR for ODS are still lacking in the literature...
July 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28572875/nerve-preserving-vs-standard-laparoscopic-sacropexy-postoperative-bowel-function
#20
Stefano Cosma, Paolo Petruzzelli, Saverio Danese, Chiara Benedetto
AIM: To compare our developed nerve preserving technique with the non-nerve preserving one in terms of de novo bowel symptoms. METHODS: Patients affected by symptomatic apical prolapse, admitted to our department and treated by nerve preserving laparoscopic sacropexy (LSP) between October, 2010 and April, 2013 (Group A or "interventional group") were compared to those treated with the standard LSP, between September, 2007 and December, 2009 (Group B or "control group")...
May 16, 2017: World Journal of Gastrointestinal Endoscopy
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