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https://www.readbyqxmd.com/read/28304122/comparative-study-of-magnetic-resonance-defaecography-and-evacuation-proctography-in-the-evaluation-of-obstructed-defaecation
#1
A Zafa, C Seretis, M Feretis, S Karandikar, S C Williams, M Goldstein, M Chapman
AIM: Obstructed defaecation syndrome (ODS) is a common condition of multifactorial aetiology and requires specialised evaluation. Accurate and reproducible pelvic floor imaging is imperative for multidisciplinary decision-making. Evacuation Proctography (EP) and Magnetic Resonance Defaecography (MRD) are the main imaging modalities used to assess dynamic pelvic floor function. The aim of this prospective study was to compare the findings and acceptability of MRD and EP in the same cohort of patients...
March 17, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#2
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28285533/determination-of-diacetyl-in-beer-by-a-pre-column-derivatization-hplc-uv-method-using-4-2-3-dimethyl-6-quinoxalinyl-1-2-benzenediamine-as-a-derivatizing-reagent
#3
Ji-Yu Wang, Xin-Jie Wang, Xian Hui, Shui-Hong Hua, Heng Li, Wen-Yun Gao
Diacetyl is an important flavoring compound in many foods, especially in beer. In the present study, we developed and validated a new pre-column derivatization HPLC-UV method for the determination of diacetyl using 4-(2,3-dimethyl-6-quinoxalinyl)-1,2-benzenediamine (DABMD) as a novel derivatizing reagent. After derivatization with DABMD at a pH value 4.0 at ambient temperature for 10 min, diacetyl was analyzed on an ODS column and detected at 254 nm. The results show that the correlation coefficient of the method is 0...
March 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28259252/a-new-diterpenoid-alkaloid-isolated-from-delphinium-caeruleum
#4
Chao-Zhan Lin, Zhu-Jie Liu, Zeren-Dawa Bairi, Chen-Chen Zhu
The present study was designed to determine the chemical constituents of Delphinium caeruleum Jacq. ex Camb.. The chemical constituents were isolated and purified by column chromatography with silica gel, ODS, and Sephadex LH-20. Their structures were elucidated by IR, MS, and NMR. Ten compounds were obtained and identified as caerudelphinine A (1), lycoctonine (2), talitine B (3), talitine A (4), talitine C (5), tatsienine-V (6), d-magnoflorine (7), 2-trimethyl-ammonio-3-(3-indolyl) propionate (8), vakhmatine (9), and delatisine (10)...
January 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28258983/pharmacokinetics-and-tissue-distribution-of-4-5-dimethoxycanthin-6-one-and-its-major-metabolites-in-rats
#5
Xiaolei Miao, Junjun Wang, Yong Chen
4,5-Dimethoxycanthin-6-one and 5-hydroxy-4-methoxycanthin-6-one are the active ingredients of P. quassiodes. In the present work, a LC-MS/MS method was developed for the determination of 4,5-dimethoxycanthin-6-one and its major metabolites 5-hydroxy-4-methoxycanthin-6-one (M1) and 4-hydroxy-5-methoxycanthin-6-one (M2) in rat plasma and tissues, and applied to study their pharmacokinetics and tissue distribution after intramuscular administration of 4,5-dimethoxycanthin-6-one to rats. By protein precipitation with methanol for plasma samples and liquid-liquid extraction with ethyl acetate for tissue samples, the analytes were separated on an ODS C18 column with a mobile phase consisted of methanol and water (0...
January 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28243183/multidisciplinary-management-of-sexual-dysfunction-perineal-pain-and-elimination-dysfunction-in-a-woman-with-multiple-sclerosis
#6
Michela Miletta, Fabrizio Bogliatto, Leonardo Bacchio
BACKGROUND: Multiple sclerosis (MS) is a chronic disease that commonly affects young women and is associated with sexual dysfunction (SD) and lower anourogenital dysfunction, which affect quality of life. We evaluated the importance of an integrated multidisciplinary approach in the Lower Female Ano-Uro-Genital Network (LFAUGN) to manage a variety of complex symptoms. METHODS: A 40-year-old woman with MS and primary concerns about perineal pain and SD was treated by a trained midwife from the LFAUGN and a physical therapist after a multidisciplinary diagnostic process that included gynecologic evaluation for perineal pain and SD, physiatric assessment, urologic assessment for bladder retention (BR), and surgical examination for obstructed defecation syndrome (ODS)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28239064/theoretical-aspects-of-triacylglycerin-positional-isomer-separation-on-reverse-phase-high-performance-liquid-chromatography
#7
Tsugihiko Hirano, Keiichi Yokochi, Koretaro Takahashi
The purpose of the present study is to bear our hypothesis and to make a profound discussion on the theoretical aspects of triacylglycerin (TG) positional isomer separation on reverse phase high performance liquid chromatography (HPLC). Authentic triacid TG positional isomers and authentic diacid TG positional isomers were injected to a monomeric and polymeric HPLC. Relationship between TG molecular structure and those elution profiles were carefully analyzed. In polymeric column, thickness of the ODS chain is high compared to monomeric column...
February 24, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28225944/-methodological-bases-and-implementation-results-of-mexico-s-national-survey-of-children-and-women-2015
#8
Filipa de Castro, Rosalba Rojas, Aremis Villalobos, Betania Allen, Celia Hubert, Martín Romero, Tonatiuh Barrientos, Erika Strand, Eva Prado, Rosa Itandehui-Olivera, Alberto Escamilla, Eduardo Lazcano, Mauricio Hernández
Objective: To describe the methodology and the implementation survey results from National Survey of Children and Women Mexico's (ENIM 2015). Materials and methods: The ENIM 2015 is a probability survey with multistage, stratified and cluster sample, with regional, rural and urban strata, and indigenous population representation.We applied questionnaires to get information from the household, women aged 15 to 49 years, children under five years and children and adolescents aged 5-17 years...
November 2016: Salud Pública de México
https://www.readbyqxmd.com/read/28224247/a-simplified-lc-ms-ms-method-for-rapid-determination-of-cycloserine-in-small-volume-human-plasma-using-protein-precipitation-coupled-with-dilution-techniques-to-overcome-matrix-effects-and-its-application-to-a-pharmacokinetic-study
#9
Zhengsheng Mao, Xin Wang, Bingxin Li, Jing Jin, Ming Xu, Youping Liu, Xin Di
Matrix effects have been a major concern when developing LC-MS/MS methods for quantitative bioanalysis of cycloserine. Sample handling procedures including solid phase extraction or derivatization have been reported previously by researchers to overcome matrix effects of cycloserine. In the present study, the possibility of reducing matrix effects of cycloserine using protein precipitation coupled with dilution techniques was investigated. Plasma samples were pretreated by protein precipitation with methanol followed by a 40-fold dilution with methanol-water (50:50, v/v)...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28191359/simultaneous-determination-of-5-flavonoids-and-7-saponins-for-quality-control-of-traditional-chinese-medicine-preparation-xinnaoshutong-capsule-using-hplc-vwd-elsd
#10
Jin Li, Yang Bai, Peng Zhang, Jun He, Jun Cao, Mingrui An, Li-Min Hu, Xiu-Mei Gao, Yan-Xu Chang
Xinnaoshutong capsule (XC) is a traditional Chinese prescription derived from the ripe fruit of Tribulus terrestris L. (TT). Although XC has long been considered as an important herbal medicine, no analytical method of marker compounds for quality assessment is registered in the Chinese Pharmacopoeia. A simple analytical method of twelve marker components was developed and validated by HPLC-VWD-ELSD method. Chromatographic separation by HPLC was carried out on a Hedera ODS 2 column (4.6 × 250 mm, 5 μm) by gradient elution with acetonitrile-water (0...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28182848/simultaneous-determination-of-8-b-vitamins-in-rat-intestinal-perfusate-to-identify-effects-of-osmotic-pressures-on-absorptions
#11
Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun
A rapid and accurate HPLC-DAD method was developed and validated to simultaneously determine eight B-vitamins (VBs, namely thiamine, riboflavin, niacinamide, calcium pantothenic, pyridoxine, biotin, folic acid, and cyanocobalamin) and phenolsulfonphthalein in rat intestinal perfusate. Chromatography separation was achieved using an Inertsil ODS-3 column (250 × 4.6 mm i.d., 5 µm) at the temperature of 40 °C. Gradient elution mode was applied at the flow rate of 1.0 mL/min with the mobile phase of acetonitrile-30 mM K2 HPO4 (pH 5...
February 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28161783/mechanism-of-extractive-oxidative-desulfurization-using-the-ionic-liquid-inimidazole-acetate-a-computational-study
#12
Hanlu Wang, Mingsheng Xu, Rujin Zhou
The dual role of the ionic liquid 1-butyl-3-methyl-imidazolium trifluoroacetic acid ([C4mim]TFA) as an extractant for thiophene (TH) and a catalyst for the oxidation of TH was explored at the molecular level by performing density functional theory (DFT) calculations. The calculated interaction energies demonstrated why [C4mim]TFA is a better extractant for thiophene sulfone (THO2) than for TH. Two pathways were proposed for the oxidation of TH to THO2 with [C4mim]TFA acting as a catalyst. In the dominant pathway, a peracid is formed which then oxidizes TH to the sulfoxide and sulfones...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28150570/identification-characterization-and-quantification-of-impurities-of-safinamide-mesilate-process-related-impurities-and-degradation-products
#13
Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui, Qiaogen Zou, Zheying Zhu
The characterization of process-related impurities and degradation products of safinamide mesilate (SAFM) in bulk drugand a stability-indicating HPLC method for the separation and quantification of all the impurities were investigated. Four process-related impurities (Imp-B, Imp-C, Imp-D, and Imp-E) were found in the SAFM bulk drug. Five degradation products (Imp-A, Imp-C, Imp-D, Imp-E, and Imp-F) were observed in SAFM under oxidative conditions. Imp-C, Imp-D, and Imp-E were also degradation products and process-related impurities...
February 2, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28132057/is-beta-blocker-use-beneficial-in-breast-cancer-a-meta-analysis
#14
Hyun Yul Kim, Youn Joo Jung, Sang Hyup Lee, Hyuk Jae Jung, Kyoungjune Pak
OBJECTIVE: Preclinical studies have proved that beta-blocking agents inhibit several pathways for breast cancer progression and metastasis. We aimed to evaluate the association between beta-blocker use and prognosis of breast cancer. METHODS: A systematic search for studies from MEDLINE and EMBASE (inception to March 2014) was performed using the keywords "breast cancer" and "beta-blocker." In 2 groups of breast cancer patients (beta-blocker users and non-beta-blocker users), overall deaths (ODs), cancer-specific deaths (CSDs), and recurrences were compared...
January 28, 2017: Oncology
https://www.readbyqxmd.com/read/28131058/analytical-method-development-and-validation-for-the-analysis-of-verapamil-hydrochloride-and-its-related-substances-by-using-ultra-perfomance-liquid-chromatography
#15
S Vijayabaskar, V Mahalingam, Kalaivani
A novel, economic, and time-efficient stability-indicating, reverse-phase ultra-performance liquid chromatographic (RP-UPLC) method has been developed for the analysis of verapamil hydrochloride in the presence of both impurities and degradation products generated by forced degradation. When verapamil hydrochloride was subjected to acid hydrolysis, oxidative, base hydrolysis, photolytic, and thermal stress, degradation was observed only in oxidative and base hydrolysis. The drug was found to be stable to other stress conditions...
January 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28120260/evaluation-of-a-premixed-insulin-analog-suspension-in-japanese-people-with-type-2-diabetes-and-the-clinical-importance-of-improved-injection-techniques-a-cross-sectional-pilot-study
#16
Kunihiro Suzuki, Chie Aoki, Kanako Kato, Masanori Shimizu, Shintaro Sakurai, Kazunori Yanagi, Hisamoto Kuroda, Yoshimasa Aso
INTRODUCTION: Patients with type 2 diabetes, who live in Asian countries, often use premixed insulin analogs. However, if these solutions are insufficiently mixed prior to use, patients will receive inaccurate doses of intermediate- and/or short-acting insulin, which could affect diabetes control. This study aimed to determine whether insulin users were correctly resuspending premixed insulin analog solutions prior to use. METHODS: We investigated whether Japanese patients with type 2 diabetes were correctly resuspending their premixed insulin analog solutions by assessing the optical densities (ODs) of the solutions...
January 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28090134/outcome-dependent-sampling-design-and-inference-for-cox-s-proportional-hazards-model
#17
Jichang Yu, Yanyan Liu, Jianwen Cai, Dale P Sandler, Haibo Zhou
We propose a cost-effective outcome-dependent sampling design for the failure time data and develop an efficient inference procedure for data collected with this design. To account for the biased sampling scheme, we derive estimators from a weighted partial likelihood estimating equation. The proposed estimators for regression parameters are shown to be consistent and asymptotically normally distributed. A criteria that can be used to optimally implement the ODS design in practice is proposed and studied. The small sample performance of the proposed method is evaluated by simulation studies...
November 2016: Journal of Statistical Planning and Inference
https://www.readbyqxmd.com/read/28079191/enhanced-radiation-tolerant-oxide-dispersion-strengthened-steel-and-its-microstructure-evolution-under-helium-implantation-and-heavy-ion-irradiation
#18
Chenyang Lu, Zheng Lu, Xu Wang, Rui Xie, Zhengyuan Li, Michael Higgins, Chunming Liu, Fei Gao, Lumin Wang
The world eagerly needs cleanly-generated electricity in the future. Fusion reactor is one of the most ideal energy resources to defeat the environmental degradation caused by the consumption of traditional fossil energy. To meet the design requirements of fusion reactor, the development of the structural materials which can sustain the elevated temperature, high helium concentration and extreme radiation environments is the biggest challenge for the entire material society. Oxide dispersion strengthened steel is one of the most popular candidate materials for the first wall/blanket applications in fusion reactor...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079022/lifitegrast-for-the-treatment-of-dry-eye-disease-results-of-a-phase-iii-randomized-double-masked-placebo-controlled-trial-opus-3
#19
Edward J Holland, Jodi Luchs, Paul M Karpecki, Kelly K Nichols, Mitchell A Jackson, Kenneth Sall, Joseph Tauber, Monica Roy, Aparna Raychaudhuri, Amir Shojaei
PURPOSE: Lifitegrast is a lymphocyte function-associated antigen-1 antagonist developed to reduce inflammation in dry eye disease (DED). We report the results of OPUS-3 (NCT02284516), a phase III study evaluating the efficacy and safety of lifitegrast versus placebo in participants with DED. DESIGN: Twelve-week, phase III, randomized, double-masked, multicenter, placebo-controlled study. PARTICIPANTS: Adults aged ≥18 years with Schirmer tear test (without anesthesia) ≥1 and ≤10 mm, corneal fluorescein staining score ≥2...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28065697/bioactive-diarylheptanoids-and-stilbenes-from-the-rhizomes-of-dioscorea-septemloba-thunb
#20
Yi Zhang, Jingya Ruan, Jian Li, Liping Chao, Wenzhong Shi, Haiyang Yu, Xiumei Gao, Tao Wang
The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1-3) and two novel stilbenes (4 and 5), together with six known ones (6-11). Their structures were elucidated on the basis of extensive 1D NMR ((1)H and (13)C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6-8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9-11 displayed triglyceride inhibitory effects in HepG2 cells...
March 2017: Fitoterapia
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