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https://www.readbyqxmd.com/read/28733713/diel-cyclic-hypoxia-alters-plasma-lipid-dynamics-and-impairs-reproduction-in-goldfish-carassius-auratus
#1
Aritra Bera, Paramita Banerjee Sawant, Subrata Dasgupta, N K Chadha, Bhawesh T Sawant, Asim Kumar Pal
Diel cyclic hypoxia occurs with varying frequency and duration in freshwater habitats, yet little is known about its effects on reproduction of freshwater fishes. The present study shows that long-term exposure of goldfish (Carassius auratus) to cyclic hypoxia (0.8 ± 0.2 mg/l dissolved oxygen) for 9 h or more, per day, altered plasma lipid and sex steroid profiles, which in turn directly or indirectly suppressed ovarian growth and viable spermatozoa production. Hypoxia decreased total cholesterol and high density lipoprotein (HDL p < 0...
July 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28731272/short-term-toxicity-of-1-methylnaphthalene-to-americamysis-bahia-and-five-deep-sea-crustaceans
#2
Anthony Knap, Nicholas R Turner, Gopal Bera, D Abigail Renegar, Tamara Frank, Jose Sericano, Bernhard M Riegl
There are few studies that have evaluated hydrocarbon toxicity to vertically migrating deep-sea micronekton. Crustaceans were collected alive using a 9 m(2) Tucker trawl with a thermally insulated cod end and returned to the laboratory in 10 °C seawater. Toxicity of the polycyclic aromatic hydrocarbon 1-methylnapthalene to Americamysis bahia, Janicella spinacauda, Systellaspis debilis, Sergestes sp., Sergia sp., and a euphausid sp. was assessed in a constant exposure toxicity test utilizing a novel passive dosing toxicity testing protocol...
July 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28724600/consumptive-hypothyroidism-in-solitary-cutaneous-haemangioma
#3
Partha Pratim Chakraborty, Mitali Bera, Shinjan Patra, Suman Roy
No abstract text is available yet for this article.
July 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28710948/brainstem-auditory-evoked-potentials-for-diagnosing-autism-spectrum-disorder-adhd-and-schizophrenia-spectrum-disorders-in-adults-a-blinded-study
#4
Irina Manouilenko, Mats B Humble, Jeanette Georgieva, Susanne Bejerot
The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n=8), or schizophrenia spectrum disorder (SSD) (n=7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients...
July 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28708419/mechanisms-of-the-formation-of-adenine-guanine-and-their-analogues-in-uv-irradiated-mixed-nh3-h2o-molecular-ices-containing-purine
#5
Partha P Bera, Tamar Stein, Martin Head-Gordon, Timothy J Lee
We investigated the formation mechanisms of the nucleobases adenine and guanine and the nucleobase analogues hypoxanthine, xanthine, isoguanine, and 2,6-diaminopurine in a UV-irradiated mixed 10:1 H2O:NH3 ice seeded with precursor purine by using ab initio and density functional theory computations. Our quantum chemical investigations suggest that a multistep reaction mechanism involving purine cation, hydroxyl and amino radicals, together with water and ammonia, explains the experimentally obtained products in an independent study...
July 14, 2017: Astrobiology
https://www.readbyqxmd.com/read/28702635/the-mechanism-of-nanoparticle-mediated-enhanced-energy-transfer-during-high-intensity-focused-ultrasound-sonication
#6
Chandan Bera, Surendra B Devarakonda, Vishal Kumar, Ashok K Ganguli, Rupak K Banerjee
In this combined experimental and theoretical research, magnetic nano-particle (mNP) mediated energy transfer due to high intensity-focused ultrasound (HIFU) sonication has been evaluated. HIFU sonications have been performed on phantoms containing three different volume percentages (0%, 0.0047%, and 0.047%) of mNPs embedded in a tissue mimicking material (TMM). A theoretical model has been developed to calculate the temperature rise in the phantoms during HIFU sonication. It is observed from theoretical calculation that the phonon layer at the interface of the mNPs and TMM dominates the attenuation for higher (0...
July 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28701356/reciprocal-expression-of-mir-214-and-pten-by-high-glucose-regulates-glomerular-mesangial-and-proximal-tubular-epithelial-cell-hypertrophy-and-matrix-expansion
#7
Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Aberrant expression of microRNAs (miRs) contributes to diabetic renal complications including renal hypertrophy and matrix protein accumulation. Reduced expression of PTEN by hyperglycemia contributes to these processes. We considered involvement of microRNA in the downregulation of PTEN. In the renal cortex of type 1 diabetic mice, we detected increased expression of miR-214 in association with decreased levels of PTEN and, enhanced Akt phosphorylation and fibronectin expression. Mesangial and proximal tubular epithelial cells exposed to high glucose showed augmented expression of miR-214...
July 12, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28693936/sirenomelia-associated-with-discoid-adrenal-and-lumbar-meningocoele-an-autopsy-report
#8
Nelofar Islam, Bappa Mandal, Ram Narayan Das, Goutam Bera, Suchandra Mukherjee, Uttara Chatterjee
Mermaid syndrome or Sirenomelia is a rare congenital deformity in which the legs are fused and bears resemblance to mermaid's tail. It carries a poor prognosis, due to associated urogenital and gastrointestinal abnormalities. An early antenatal diagnosis using Magnetic Resonance Imaging (MRI) can help in termination of pregnancy. Embryologically, it is considered as the extreme form of caudal regression syndrome due to the persistence of vitelline artery. Here, we report a case of Sirenomelia associated with bilateral renal agenesis along with the rare findings of discoid adrenal, lumbar meningocoele and abnormalities of the hand...
June 17, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28688948/kondogogu-gum-zn-2-pectinate-emulgel-matrices-reinforced-with-mesoporous-silica-for-intragastric-furbiprofen-delivery
#9
Hriday Bera, Jhansirani Nadimpalli, Sanoj Kumar, Pavani Vengala
Flurbiprofen (FLU), a non-steroidal anti-inflammatory drug, exhibits limited clinical response due to its poor physicochemical properties. This study aimed at developing reliable drug carriers for intrgastric FLU delivery with a view to improve biopharmaceutical characteristics of drug and modulate its release in a controlled manner. In this context, FLU-loaded kondogogu gum (KG)-Zn(+2)-low methoxyl (LM) pectinate emulgel matrices reinforced with calcium silicate (CS) were accomplished by ionotropic gelation technique employing zinc acetate as cross-linker and characterized for their in vitro performances...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28679755/pleiotropic-effects-of-resistance-breaking-mutations-on-particle-stability-provide-insight-on-life-history-evolution-in-a-plant-rna-virus
#10
Sayanta Bera, Manuel G Moreno-Pérez, Sara García-Figuera, Israel Pagán, Aurora Fraile, Luis F Pacios, Fernando García-Arenal
In gene-for-gene host-virus interactions, virus evolution to infect and multiply in previously resistant host genotypes, i.e., resistance-breaking, is a case of host range expansion, predicted to be associated with fitness penalties. Negative effects of resistance-breaking mutations on within-host virus multiplication have been documented for several plant viruses. However, understanding virus evolution requires analyses of potential trade-offs between different fitness components. Here we analyze if coat protein (CP) mutations in Pepper mild mottle virus breaking L-gene resistance in pepper affect particle stability and, thus, survival in the environment...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28678296/structural-insights-into-the-multinuclear-speciation-of-tetravalent-cerium-in-the-tri-n-butyl-phosphate-n-dodecane-solvent-extraction-system
#11
Mark R Antonio, Ross J Ellis, Shanna L Estes, Mrinal K Bera
X-ray and electrochemical studies of organic phases obtained by the extraction of tetravalent cerium, Ce(iv), from aqueous nitric acid (3 M) with tri-n-butyl phosphate (TBP) in n-dodecane reveal a tetranuclear Ce(iv) structural motif. This finding is consistent with the results of previous liquid-liquid extraction (LLE) studies that implicate the aggregation of (Ce-O-Ce)(6+) dimers into multinuclear Ce(iv)·TBP solvates. The organic solution structures elaborated here for the Ce(iv)-HNO3-20% TBP-n-C12H26 system are correlated with multiscale phenomena-from the atomic level of the cerium coordination environment to the supramolecular scale of solute aggregates-in the organic phases, which are of relevance to the PUREX (Plutonium Uranium Reduction EXtraction) process...
July 5, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28674083/combining-local-immunotoxins-targeting-mesothelin-with-ctla-4-blockade-synergistically-eradicates-murine-cancer-by-promoting-anti-cancer-immunity
#12
Yasmin Leshem, James O'Brien, Xiufen Liu, Tapan K Bera, Masaki Terabe, Jay A Berzofsky, Birgit Bossenmaier, Gerhard Niederfellner, Chin-Hsien Tai, Yoram Reiter, Ira Pastan
Immune checkpoint blockade using antibodies to cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) benefits a limited number of cancer patients. SS1P and LMB-100 are immunotoxins that target mesothelin. We observed delayed responses to SS1P in patients with mesothelioma suggesting that anti-tumor immunity was induced. Our goal was to stimulate anti-tumor immunity by combining SS1P or LMB-100 with anti-CTLA-4. We constructed a BALB/c breast cancer cell line expressing human mesothelin (66C14-M) which was implanted in one or two locations...
July 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28668216/-drugs-news
#13
L Vrignaud, C Simon, M-S Agier, T Bejan-Angoulvant, E Bouquet, F Beau-Salinas, A-P Jonville-Béra
No abstract text is available yet for this article.
June 28, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28657366/psychiatric-disorders-acne-and-systemic-retinoids-comparison-of-risks
#14
M Le Moigne, S Bulteau, Marie Grall-Bronnec, M Gerardin, Jean-Pascal Fournier, A P Jonville-Bera, Pascale Jolliet, Brigitte Dreno, C Victorri-Vigneau
BACKGROUND: The link between isotretinoin, treatment of a severe form of acne, and psychiatric disorders remains controversial, as acne itself could explain the occurrence of psychiatric disorders. This study aims at assessing the disproportionality of psychiatric adverse events reported with isotretinoin in the French National PharmacoVigilance Database, compared with other systemic acne treatments and systemic retinoids. MATERIALS AND METHODS: Data were extracted from the French National PharmacoVigilance Database for systemic acne treatments, systemic retinoids and drugs used as comparators...
June 28, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28631020/utility-of-pas-and-%C3%AE-catenin-staining-in-histological-categorisation-and-prediction-of-prognosis-of-hepatoblastomas
#15
Goutam Bera, Ram Narayan Das, Paromita Roy, Ranajoy Ghosh, Nelofar Islam, Prafulla Kumar Mishra, Uttara Chatterjee
AIMS: The aim of this study was to assess the usefulness of PAS, β-catenin and Ki-67 in categorising hepatoblastomas (HBs) and their significance in predicting prognosis. In addition, we have also documented the various chemotherapy induced histologic changes in HBs. METHOD: In this retrospective observational study of 29 cases of hepatoblastomas, 27 cases were considered for statistical analysis, excluding two cases of diagnostic core biopsies. All clinicopathological parameters and follow up data were collected...
June 19, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28607889/outcomes-of-newborn-hearing-screening-program-a-hospital-based-study
#16
Kavita Sachdeva, Tulsi Sao
Hearing loss is hidden disability and second most common congenital pathology. Prevention, early identification and early intervention of hearing loss can prevent further disability in development of speech, language, cognition and other developmental domains. The prevalence of congenital hearing loss has been estimated to be 1.2-5.7 per thousand in neonates. In these contexts, the aim of study was to determine outcomes of neonates hearing screening program in Hospital. It is a clinical cross-sectional study which was conducted in tertiary care centre from 8th July, 2015 to 31th May, 2016...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28604358/dual-stage-beamforming-in-absence-of-front-end-receive-focusing
#17
Deep Bera, Johan Bosch, Martin Verweij, Nico De Jong, Hendrik Vos
Ultrasound front-end receive designs for miniature, wireless, and/or matrix transducers might be simplified considerably by direct element summation in receive. In this paper we develop a dual-stage beamforming technique which is able to produce a high quality image from scanlines that are produced with focused transmit, and simple summation in receive (no delays). We call this Non-Delayed Sequential Beamforming (NDSB). In the first stage, low-resolution RF scanlines are formed by simple summation of element signals from a running sub-aperture...
June 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28599607/the-accuracy-of-objective-threshold-determination-at-low-frequencies-comparison-of-different-auditory-brainstem-response-abr-and-auditory-steady-state-response-assr-methods
#18
Jacqueline Frank, Izet Baljić, Sebastian Hoth, Dirk Eßer, Orlando Guntinas-Lichius
OBJECTIVE: The hearing threshold at 500 Hz was estimated using five methods which are suitable for the low frequency range: Low-Chirp BERA (LCBERA), Notched-noise BERA (NNBERA), Narrow band CE-Chirp BERA (NBCBERA) and Narrow band CE-Chirp ASSR (NBCASSR) (40/90 Hz). The slope of the discrimination function of each method was used for determination of the most efficient method. The threshold values were compared and the corresponding odds ratios (OR) were calculated. DESIGN: All methods were applied to each subject...
May 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28594387/3d-printing-based-integrated-water-quality-sensing-system
#19
Muinul Banna, Kaustav Bera, Ryan Sochol, Liwei Lin, Homayoun Najjaran, Rehan Sadiq, Mina Hoorfar
The online and accurate monitoring of drinking water supply networks is critically in demand to rapidly detect the accidental or deliberate contamination of drinking water. At present, miniaturized water quality monitoring sensors developed in the laboratories are usually tested under ambient pressure and steady-state flow conditions; however, in Water Distribution Systems (WDS), both the pressure and the flowrate fluctuate. In this paper, an interface is designed and fabricated using additive manufacturing or 3D printing technology-material extrusion (Trade Name: fused deposition modeling, FDM) and material jetting-to provide a conduit for miniaturized sensors for continuous online water quality monitoring...
June 8, 2017: Sensors
https://www.readbyqxmd.com/read/28589503/promise-of-adeno-associated-virus-as-a-gene-therapy-vector-for-cardiovascular-diseases
#20
REVIEW
Abesh Bera, Dwaipayan Sen
Cardiovascular diseases pose a unique threat to global mortality because it presents as one of the most diverse conglomerations of pathophysiological conditions that can create significant casualty even without straying into its collateral damage. This puts them right beside obesity and cancer in terms of severity. Their pervasive nature and high prevalence prompted biologists to seek newer prophylactic avenues of addressing this global hazard, among which adeno-associated virus (AAV) gene therapy rose to significant prominence...
June 7, 2017: Heart Failure Reviews
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