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https://www.readbyqxmd.com/read/28332666/direct-observation-of-breathing-dynamics-at-the-mismatch-induced-dna-bubble-with-nanometre-accuracy-a-smfret-study
#1
Tapas Paul, Subhas C Bera, Padmaja P Mishra
The detailed conformational dynamics of the melted region in double-stranded DNA has been studied using a combination of ensemble and single-molecule FRET techniques. We monitored the millisecond time scale fluctuation kinetics of the two strands at the bubble region that varies with the size of the bubble. As the individual strands at the melting bubble behave as single-stranded DNA, and hence fluctuate dynamically to attain energetically favored configurations, the rates of these fluctuations increase with increase in the bubble size...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28327594/aspirin-induces-cell-death-by-directly-modulating-mitochondrial-voltage-dependent-anion-channel-vdac
#2
Debanjan Tewari, Dhriti Majumdar, Sirisha Vallabhaneni, Amal Kanti Bera
Aspirin induces apoptotic cell death in various cancer cell lines. Here we showed that silencing of VDAC1 protected HeLa cells from aspirin-induced cell death. Compared to the wild type cells, VDAC1 knocked down cells showed lesser change of mitochondrial membrane potential (Δψm), upon aspirin treatment. Aspirin augmented ATP and ionomycin-induced mitochondrial Ca(2+) uptake which was abolished in VDAC1 knocked down cells. Aspirin dissociated bound hexokinase II (HK-II) from mitochondria. Further, aspirin promoted the closure of recombinant human VDAC1, reconstituted in planar lipid bilayer...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325024/balance-quality-assessment-as-an-early-indicator-of-physical-frailty-in-older-people
#3
Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene
Frailty is an increasingly common geriatric condition that results in an increased risk of adverse health outcomes such as falls. The most widely-used means of detecting frailty is the Fried phenotype, which includes several objective measures such as grip strength and gait velocity. One method of screening for falls is to measure balance, which can be done by a range of techniques including the assessment of the Centre of Pressure (CoP) during a balance assessment. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that can evaluate balance quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28319997/intradiscal-glucocorticoid-injection-for-patients-with-chronic-low-back-pain-associated-with-active-discopathy-a-randomized-trial
#4
Christelle Nguyen, Isabelle Boutron, Gabriel Baron, Katherine Sanchez, Clémence Palazzo, Raphaël Benchimol, Guillaume Paris, Étienne James-Belin, Marie-Martine Lefèvre-Colau, Johann Beaudreuil, Jean-Denis Laredo, Anne Béra-Louville, Anne Cotten, Jean-Luc Drapé, Antoine Feydy, Philippe Ravaud, François Rannou, Serge Poiraudeau
Background: Active discopathy is associated with a specific phenotype of chronic low back pain (LBP). Local inflammation has a role in active discopathy-associated symptoms. Objective: To assess the efficacy of a single glucocorticoid intradiscal injection (GC IDI) in patients with chronic LBP with active discopathy. Design: Prospective, parallel-group, double-blind, randomized, controlled study. (ClinicalTrials.gov: NCT00804531). Setting: 3 tertiary care centers in France...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28295982/light-harvesting-and-photocurrent-generation-in-a-conjugated-polymer-nanoparticle-reduced-graphene-oxide-composite
#5
Amitava Patra, Arnab Ghosh, Bikash Jana, Sourav Maiti, Rajesh Bera, Hiren Ghosh
Polymer - graphene nanocomposites are promising candidates towards light harvesting systems such as photocatalysis, photovoltaics; where significant charge separation occurs due to photoinduced electron transfer. Much attention has been paid to use reduced graphene oxide (r-GO) as template for anchoring various nanomaterials due to its efficient electron accepting and transport property. Here, we have prepared Poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles from MEH-PPV polymer and investigate the change in photophysical properties due to formation of polymer nanoparticles from molecular state by using steady state and time resolved spectroscopy...
March 14, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28295109/interplaying-anions-in-a-supramolecular-metallohydrogel-to-form-metal-organic-frameworks
#6
Suvendu Karak, Sushil Kumar, Saibal Bera, David Díaz Díaz, Subhrashis Banerjee, Kumar Vanka, Rahul Banerjee
The remarkable effect of anions on the transition from supramolecular gels to crystalline phases has been described. An amino acid-based metallohydrogel was transformed into different metal-organic frameworks through the selective picking of anions. The metallohydrogel and the resulting metal-organic frameworks (MOFs) were thoroughly characterized. The results demonstrated controlled access over the binding of a particular anion to selectively form a particular MOF.
March 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28290215/genetic-assessment-of-leech-species-from-yak-bos-grunniens-in-the-tract-of-northeast-india
#7
Nilkantha Chatterjee, Bishal Dhar, Debasis Bhattarcharya, Sourabh Deori, Juwar Doley, Joken Bam, Pranab J Das, Asit K Bera, Sitangshu M Deb, Ningthoujam Neelima Devi, Rajesh Paul, Sorokhaibam Malvika, Sankar Kumar Ghosh
Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech...
March 14, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28287406/mesothelin-mucin-16-signaling-in-activated-portal-fibroblasts-regulates-cholestatic-liver-fibrosis
#8
Yukinori Koyama, Ping Wang, Shuang Liang, Keiko Iwaisako, Xiao Liu, Jun Xu, Mingjun Zhang, Mengxi Sun, Min Cong, Daniel Karin, Kojiro Taura, Chris Benner, Sven Heinz, Tapan Bera, David A Brenner, Tatiana Kisseleva
Cholestatic liver fibrosis is caused by obstruction of the biliary tract and is associated with early activation of portal fibroblasts (PFs) that express Thy-1, fibulin 2, and the recently identified marker mesothelin (MSLN). Here, we have demonstrated that activated PFs (aPFs) and myofibroblasts play a critical role in the pathogenesis of liver fibrosis induced by bile duct ligation (BDL). Conditional ablation of MSLN+ aPFs in BDL-injured mice attenuated liver fibrosis by approximately 50%. Similar results were observed in MSLN-deficient mice (Msln-/- mice) or mice deficient in the MSLN ligand mucin 16 (Muc16-/- mice)...
March 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28280580/organization-of-biogeochemical-nitrogen-pathways-with-switch-like-adjustment-in-fluctuating-soil-redox-conditions
#9
Sanjay Lamba, Soumen Bera, Mubasher Rashid, Alexander B Medvinsky, Gui-Quan Sun, Claudia Acquisti, Amit Chakraborty, Bai-Lian Li
Nitrogen is cycled throughout ecosystems by a suite of biogeochemical processes. The high complexity of the nitrogen cycle resides in an intricate interplay between reversible biochemical pathways alternatively and specifically activated in response to diverse environmental cues. Despite aggressive research, how the fundamental nitrogen biochemical processes are assembled and maintained in fluctuating soil redox conditions remains elusive. Here, we address this question using a kinetic modelling approach coupled with dynamical systems theory and microbial genomics...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28263578/molecular-and-electronic-structures-of-ruthenium-complexes-containing-an-ons-coordinated-open-shell-%C3%AF-radical-and-an-oxidative-aromatic-ring-cleavage-reaction
#10
Suvendu Maity, Suman Kundu, Sandip Mondal, Sachinath Bera, Prasanta Ghosh
The coordination chemistry of 2,4-di-tert-butyl-6-[(2-mercaptophenyl)amino]phenol (LONSH3), which was isolated as a diaryl disulfide form, (LONSH2)2, with a Ru ion is disclosed. It was established that the trianionic LONS(3-) is redox-noninnocent and undergoes oxidation to either a closed-shell singlet (CSS), LONS(-), or an open-shell π-radical state, LONS(•2-), and the reactivities of the [Ru(II)(LONS(•2-))] and [Ru(II)(LONS(-))] states are different. The reaction of (LONSH2)2 with [Ru(PPh3)3Cl2] in toluene in the presence of PPh3 affords a ruthenium complex of the type trans-[Ru(LONS)(PPh3)2Cl] (1), while the similar reaction with [Ru(PPh3)3(H)(CO)Cl] yields a LONS(•2-) complex of ruthenium(II) of the type trans-[Ru(II)(LONS(•2-))(PPh3)2(CO)] (2)...
March 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28254636/land-plus-aquatic-therapy-versus-land-based-rehabilitation-alone-for-the-treatment-of-balance-dysfunction-in-parkinson-s-disease-a-randomized-controlled-study-with-6-month-follow-up
#11
Grazia Palamara, Francesco Gotti, Roberto Maestri, Rossana Bera, Roberto Gargantini, Fabiola Bossio, Ilaria Zivi, Daniele Volpe, Davide Ferrazzoli, Giuseppe Frazzitta
OBJECTIVES: To assess whether a specific land-based physical intervention with the inclusion of aquatic therapy is more effective than land-based rehabilitation alone for the treatment of balance dysfunction in patients with Parkinson's disease (PD). To test the effect of these rehabilitative approaches after a 6-month follow-up period. DESIGN: Randomized controlled study with 6-month follow-up. SETTING: Department of Parkinson's Disease and Brain Injury Rehabilitation of the 'Moriggia-Pelascini' Hospital - Gravedona ed Uniti (CO, Italy)...
February 27, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28254574/structural-insight-of-an-antioxidative-arabinogalactan-protein-of-aegle-marmelos-fruit-gum-and-it-s-interaction-with-%C3%AE-lactoglobulin
#12
Kaushik Bera, Sayani Ray, Washim Raja, Bimalendu Ray
The complication of arabinogalactan protein (AGP) structure, a significant ingredient of gum polysaccharides, not merely hinders the allocation of its role, but restricts its utilization as well. Here, we describe structural details of an AGP purified from Aegle marmelos fruit gum. This AGP (310×10(3)g/mol), which is water-soluble, contains β-1,3-linked galactopyranosyl main chain substituted at O-6 position with side chains containing galactose and arabinose residues. Also data on sugar composition, ring size, glycosidic linkage pattern, anomeric configuration and sequence of monosaccharide units of a number of oligosaccharides produced from this AGP by chemical and enzymatic methods were acquired...
February 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28242152/-post-licensure-safety-surveillance-for-prevenar-13-%C3%A2-in-france
#13
M-S Agier, S Marchand, N Paret, S Gautier, A-P Jonville-Béra
OBJECTIVE: To describe the profile and the incidence of adverse events (AEs) reported with Prevenar 13(®) since its commercialization. METHOD: Analysis of all adverse events reported with Prevenar 13(®) in France between 1st July 2010 and 31 October 2014. RESULTS: In 4 years and 4 months, 376 AEs, including 252 severe (67%), were recorded, 83 of which occurred following an injection of Prevenar 13(®) alone: 39 cutaneous AEs, 16 neurological AEs, four cases of collapse or shock, nine cases of fever, and one of thrombocytopenia...
February 24, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28237818/quercetin-inhibits-acid-sensing-ion-channels-through-a-putative-binding-site-in-the-central-vestibular-region
#14
Mohona Mukhopadhyay, Anurag Singh, S Sachchidanand, Amal Kanti Bera
Acid-sensing ion channels (ASICs) are associated with many pathophysiological processes, such as neuronal death during ischemic stroke, epileptic seizure and nociception. However, there is a dearth of ASIC-specific therapeutic blockers. Here we report that quercetin, a plant flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2µM. Also, quercetin prevents low pH-induced intracellular calcium rise and cell death in HEK-293 cells, which have endogenous expression of ASIC1a and 2a...
February 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28227723/balance-quality-assessment-as-an-early-indicator-of-physical-frailty-in-older-people
#15
Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene, Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene, J L Novella, David J Hewson, Jacques Duchene, M Collart, Aly Chkeir, D Bera, M Drame, Doha Safieddine
Frailty is an increasingly common geriatric condition that results in an increased risk of adverse health outcomes such as falls. The most widely-used means of detecting frailty is the Fried phenotype, which includes several objective measures such as grip strength and gait velocity. One method of screening for falls is to measure balance, which can be done by a range of techniques including the assessment of the Centre of Pressure (CoP) during a balance assessment. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that can evaluate balance quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28192651/current-rectification-through-vertical-heterojunctions-between-two-single-layer-dichalcogenides-wse2-mos2-pn-junctions
#16
Hrishikesh Bhunia, Abhijit Bera, Amlan J Pal
We form junctions between two single layers of p-type WSe2 and n-type MoS2 in both sequences. The WSe2|MoS2 and MoS2|WSe2 junctions of ultimate thickness limit exhibit current rectification when characterized vertically with a scanning tunneling microscope (STM) tip. The direction of rectification in the pn-junction is opposite to that of the np-junction, confirming occurrence of the rectification to be due to the junctions themselves. From scanning tunneling spectroscopy (STS) and correspondingly the density of states (DOS), we locate the conduction and valence band edges (CB and VB, respectively) of the materials inferring their single-layer and 2H phase configuration...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28187202/asymptomatic-leishmaniasis-in-kala-azar-endemic-areas-of-malda-district-west-bengal-india
#17
Pabitra Saha, Swagata Ganguly, Moytrey Chatterjee, Soumendu Bikash Das, Pratip K Kundu, Subhasish K Guha, Tamal K Ghosh, Dilip K Bera, Nandita Basu, Ardhendu K Maji
Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28184005/a-c-terminal-tail-region-in-the-rous-sarcoma-virus-integrase-provides-high-plasticity-of-functional-integrase-oligomerization-during-intasome-assembly
#18
Krishan K Pandey, Sibes Bera, Ke Shi, Hideki Aihara, Duane P Grandgenett
The retrovirus integrase (IN) inserts the viral cDNA into the host DNA genome. Atomic structures of five different retrovirus INs complexed with their respective viral DNA or branched viral/target DNA substrates have indicated these intasomes are composed of IN subunits ranging from tetramers, to octamers or to hexadecamers. IN precursors are monomers, dimers or tetramers in solution. But, how intasome assembly is controlled remains unclear. Therefore, we sought to unravel the functional mechanisms in different intasomes...
February 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28183624/hierarchical-surface-patterning-of-ni-and-be-free-ti-and-zr-based-bulk-metallic-glasses-by-thermoplastic-net-shaping
#19
Baran Sarac, Supriya Bera, Sascha Balakin, Mihai Stoica, Mariana Calin, Jürgen Eckert
In order to establish a strong cell-material interaction, the surface topography of the implant material plays an important role. This contribution aims to analyze the formation kinetics of nickel and beryllium-free Ti- and Zr-based Bulk Metallic Glasses (BMGs) with potential biomedical applications. The surface patterning of the BMGs is achieved by thermoplastic net-shaping (TPN) into anisotropically etched cavities of silicon chips. The forming kinetics of the BMG alloys is assessed by thermal and mechanical measurements to determine the most suitable processing temperature and time, and load applied...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28174771/inter-ligand-electronic-coupling-mediated-through-a-dimetal-bridge-dependence-on-metal-ions-and-ancillary-ligands
#20
Moumita Majumdar, Sayantani Saha, Indranil Dutta, Arup Sinha, Jitendra K Bera
A series of Mo2, Ru2, Rh2 and Cu2 complexes with redox-active NP-R [2-(2-R)-1,8-naphthyridine; R = pyrazinyl (NP-pz, L(1)) and thiazolyl (NP-tz, L(2))] ligands have been synthesized and characterized by X-ray crystallography and spectroscopic methods. Two NP-R ligands wrap the dimetal core by occupying four equatorial positions and two axial sites. The remaining four equatorial sites are engaged by bridging acetates in quadruply bonded cis-[Mo2(L(1))2(OAc)2][BF4]2 (1), cis-[Mo2(L(2))2(OAc)2][BF4]2 (1A), doubly bonded cis-[Ru2(L(1))2(OAc)2][ClO4]2 (3), cis-[Ru2(L(2))2(OAc)2][ClO4]2 (3A) and singly bonded trans-[Rh2(L(1))2(OAc)2][BF4]2 (5) and trans-[Rh2(L(2))2(OAc)2][BF4]2 (5A)...
February 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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