Han Soo Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Hye Sun Lee, Michel J Grothe, Stefan Teipel, Enrica Cavedo, Andrea Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyoo
BACKGROUND: Degeneration of cholinergic basal forebrain (BF) neurons characterizes Alzheimer's disease (AD). However, what role the BF plays in the dynamics of AD pathophysiology has not been investigated precisely. OBJECTIVE: To investigate the baseline and longitudinal roles of BF along with core neuropathologies in AD. METHODS: In this retrospective cohort study, we enrolled 113 subjects (38 amyloid [Aβ]-negative cognitively unimpaired, 6 Aβ-positive cognitively unimpaired, 39 with prodromal AD, and 30 with AD dementia) who performed brain MRI for BF volume and cortical thickness, 18F-florbetaben PET for Aβ, 18F-flortaucipir PET for tau, and detailed cognitive testing longitudinally...
April 16, 2024: Journal of Alzheimer's Disease: JAD