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https://www.readbyqxmd.com/read/28335588/recovery-of-nk-cd56-cd3-cells-after-1-year-of-tenofovir-therapy-for-chronic-hepatitis-b-infection
#1
Hwan Hee Lee, Hyojeung Kang, Hyosun Cho
Natural killer (NK) cells have been reported to be dysfunctional in chronic hepatitis B (CHB) infection. However, the functional recovery of NK cells was not clearly understood under anti-viral therapeutic agents in CHB. In this study, we investigated the phenotypic changes of NK(CD56+CD3-) cells in terms of their functional markers (CD16, NKG2A, NKG2D) during tenofovir therapy in CHB. The frequency of NK(CD56+CD3-) cells in CHB patients was significantly increased after 12 months of tenofovir therapy when compared to baseline...
March 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28335571/3-substituted-n-benzylpyrazine-2-carboxamide-derivatives-synthesis-antimycobacterial-and-antibacterial-evaluation
#2
Lucia Semelková, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, František Trejtnar, Vladimír Kubíček, Jiří Kuneš, Martin Doležal, Jan Zitko
A series of substituted N-benzyl-3-chloropyrazine-2-carboxamides were prepared as positional isomers of 5-chloro and 6-chloro derivatives, prepared previously. During the aminolysis of the acyl chloride, the simultaneous substitution of chlorine with benzylamino moiety gave rise to N-benzyl-3-(benzylamino)pyrazine-2-carboxamides as side products, in some cases. Although not initially planned, the reaction conditions were modified to populate this double substituted series. The final compounds were tested against four mycobacterial strains...
March 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335556/trm5-and-trmd-two-enzymes-from-distinct-origins-catalyze-the-identical-trna-modification-m%C3%A2-g37
#3
REVIEW
Sakurako Goto-Ito, Takuhiro Ito, Shigeyuki Yokoyama
The N¹-atom of guanosine at position 37 in transfer RNA (tRNA) is methylated by tRNA methyltransferase 5 (Trm5) in eukaryotes and archaea, and by tRNA methyltransferase D (TrmD) in bacteria. The resultant modified nucleotide m¹G37 positively regulates the aminoacylation of the tRNA, and simultaneously functions to prevent the +1 frameshift on the ribosome. Interestingly, Trm5 and TrmD have completely distinct origins, and therefore bear different tertiary folds. In this review, we describe the different strategies utilized by Trm5 and TrmD to recognize their substrate tRNAs, mainly based on their crystal structures complexed with substrate tRNAs...
March 21, 2017: Biomolecules
https://www.readbyqxmd.com/read/28335555/activity-recognition-and-semantic-description-for-indoor-mobile-localization
#4
Sheng Guo, Hanjiang Xiong, Xianwei Zheng, Yan Zhou
As a result of the rapid development of smartphone-based indoor localization technology, location-based services in indoor spaces have become a topic of interest. However, to date, the rich data resulting from indoor localization and navigation applications have not been fully exploited, which is significant for trajectory correction and advanced indoor map information extraction. In this paper, an integrated location acquisition method utilizing activity recognition and semantic information extraction is proposed for indoor mobile localization...
March 21, 2017: Sensors
https://www.readbyqxmd.com/read/28335553/biosynthesis-of-polyunsaturated-fatty-acids-in-octopus-vulgaris-molecular-cloning-and-functional-characterisation-of-a-stearoyl-coa-desaturase-and-an-elongation-of-very-long-chain-fatty-acid-4-protein
#5
Óscar Monroig, Rosa de Llanos, Inmaculada Varó, Francisco Hontoria, Douglas R Tocher, Sergi Puig, Juan C Navarro
Polyunsaturated fatty acids (PUFAs) have been acknowledged as essential nutrients for cephalopods but the specific PUFAs that satisfy the physiological requirements are unknown. To expand our previous investigations on characterisation of desaturases and elongases involved in the biosynthesis of PUFAs and hence determine the dietary PUFA requirements in cephalopods, this study aimed to investigate the roles that a stearoyl-CoA desaturase (Scd) and an elongation of very long-chain fatty acid 4 (Elovl4) protein play in the biosynthesis of essential fatty acids (FAs)...
March 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28335539/abundance-of-pathogenic-escherichia-coli-virulence-associated-genes-in-well-and-borehole-water-used-for-domestic-purposes-in-a-peri-urban-community-of-south-africa
#6
Akebe Luther King Abia, Lisa Schaefer, Eunice Ubomba-Jaswa, Wouter Le Roux
In the absence of pipe-borne water, many people in Africa, especially in rural communities, depend on alternative water sources such as wells, boreholes and rivers for household and personal hygiene. Poor maintenance and nearby pit latrines, however, lead to microbial pollution of these sources. We evaluated the abundance of Escherichia coli and the prevalence of pathogenic E. coli virulence genes in water from wells, boreholes and a river in a South African peri-urban community. Monthly samples were collected between August 2015 and November 2016...
March 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335535/enterovirus-71-neutralizing-antibodies-seroepidemiological-research-among-children-in-guangzhou-china-between-2014-and-2015-a-cross-sectional-study
#7
Dingmei Zhang, Yan Chen, Xiashi Chen, Zhenjian He, Xun Zhu, Yuantao Hao
A hand-foot-mouth disease outbreak occurred in 2014 around Guangdong. The purpose of this study was investigating the status and susceptibility of infectious neutralizing antibodies to enterovirus 71 among children so as to provide scientific evidence for the population immunity level of hand-foot-mouth disease and prepare for enterovirus 71 vaccination implementation. Serum specimens were collected from children in communities from January 2014 to March 2015 in Guangzhou. A total of 197 serum samples from children 1-5 years old were collected for this cross-sectional study via non-probabilistic sampling from the database of Chinese National Science and Technique Major Project...
March 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335529/effects-of-momordica-charantia-bitter-melon-on-ischemic-diabetic-myocardium
#8
Attila Czompa, Alexandra Gyongyosi, Kitti Szoke, Istvan Bak, Evelin Csepanyi, David D Haines, Arpad Tosaki, Istvan Lekli
Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related cardiovascular disease. Methods: Male Lean and Zucker Obese (ZO) rats were gavage-treated for six weeks with 400 mg/kg body weight bitter melon (BM) extract suspended in mucin-water vehicle, or with vehicle (Control). Animals were segregated into four treatment groups, 10 animals in each group, according to strain (Lean or ZO) and treatment (Control or BM)...
March 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335517/state-of-the-art-on-functional-virgin-olive-oils-enriched-with-bioactive-compounds-and-their-properties
#9
REVIEW
Patricia Reboredo-Rodríguez, María Figueiredo-González, Carmen González-Barreiro, Jesús Simal-Gándara, María Desamparados Salvador, Beatriz Cancho-Grande, Giuseppe Fregapane
Virgin olive oil, the main fat of the Mediterranean diet, is per se considered as a functional food-as stated by the European Food Safety Authority (EFSA)-due to its content in healthy compounds. The daily intake of endogenous bioactive phenolics from virgin olive oil is variable due to the influence of multiple agronomic and technological factors. Thus, a good strategy to ensure an optimal intake of polyphenols through habitual diet would be to produce enriched virgin olive oil with well-known bioactive polyphenols...
March 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335512/symptoms-relevant-to-surveillance-for-ovarian-cancer
#10
Robert M Ore, Lauren Baldwin, Dylan Woolum, Erika Elliott, Christiaan Wijers, Chieh-Yu Chen, Rachel W Miller, Christopher P DeSimone, Frederick R Ueland, Richard J Kryscio, John R van Nagell, Edward J Pavlik
To examine how frequently and confidently healthy women report symptoms during surveillance for ovarian cancer. A symptoms questionnaire was administered to 24,526 women over multiple visits accounting for 70,734 reports. A query of reported confidence was included as a confidence score (CS). Chi square, McNemars test, ANOVA and multivariate analyses were performed. 17,623 women completed the symptoms questionnaire more than one time and >9500 women completed it more than one four times for >43,000 serially completed questionnaires...
March 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28335509/novel-diagnostic-and-predictive-biomarkers-in-pancreatic-adenocarcinoma
#11
REVIEW
John C Chang, Madappa Kundranda
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease for a multitude of reasons including very late diagnosis. This in part is due to the lack of understanding of the biological behavior of PDAC and the ineffective screening for this disease. Significant efforts have been dedicated to finding the appropriate serum and imaging biomarkers to help early detection and predict response to treatment of PDAC. Carbohydrate antigen 19-9 (CA 19-9) has been the most validated serum marker and has the highest positive predictive value as a stand-alone marker...
March 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335505/porcine-epidemic-diarrhea-virus-induces-autophagy-to-benefit-its-replication
#12
Xiaozhen Guo, Mengjia Zhang, Xiaoqian Zhang, Xin Tan, Hengke Guo, Wei Zeng, Guokai Yan, Atta Muhammad Memon, Zhonghua Li, Yinxing Zhu, Bingzhou Zhang, Xugang Ku, Meizhou Wu, Shengxian Fan, Qigai He
The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic diarrhea virus (PEDV) infection has not been reported. In this study, autophagy was demonstrated to be triggered by the effective replication of PEDV through transmission electron microscopy, confocal microscopy, and Western blot analysis. Moreover, autophagy was confirmed to benefit PEDV replication by using autophagy regulators and RNA interference...
March 19, 2017: Viruses
https://www.readbyqxmd.com/read/28335498/on-the-prediction-of-flickr-image-popularity-by-analyzing-heterogeneous-social-sensory-data
#13
Samah Aloufi, Shiai Zhu, Abdulmotaleb El Saddik
The increase in the popularity of social media has shattered the gap between the physical and virtual worlds. The content generated by people or social sensors on social media provides information about users and their living surroundings, which allows us to access a user's preferences, opinions, and interactions. This provides an opportunity for us to understand human behavior and enhance the services provided for both the real and virtual worlds. In this paper, we will focus on the popularity prediction of social images on Flickr, a popular social photo-sharing site, and promote the research on utilizing social sensory data in the context of assisting people to improve their life on the Web...
March 19, 2017: Sensors
https://www.readbyqxmd.com/read/28335470/design-of-new-benzo-h-chromene-derivatives-antitumor-activities-and-structure-activity-relationships-of-the-2-3-positions-and-fused-rings-at-the-2-3-positions
#14
Rawda M Okasha, Fawzia F Alblewi, Tarek H Afifi, Arshi Naqvi, Ahmed M Fouda, Al-Anood M Al-Dies, Ahmed M El-Agrody
A series of novel 4H-benzo[h]chromenes 4, 6-11, 13, 14; 7H-benzo[h]chromeno[2,3-d]pyrimidines 15-18, 20, and 14H-benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 19a-e, 24 was prepared. The structures of the synthesized compounds were characterized on the basis of their spectral data. Some of the target compounds were examined for their antiproliferative activity against three cell lines; breast carcinoma (MCF-7), human colon carcinoma (HCT-116) and hepatocellular carcinoma (HepG-2). The cytotoxic behavior has been tested using MTT assay and the inhibitory activity was referenced to three standard anticancer drugs: vinblastine, colchicine and doxorubicin...
March 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335467/through-the-kinesthetic-lens-observation-of-social-attunement-in-autism-spectrum-disorders
#15
Rosemarie Samaritter, Helen Payne
This paper will present a movement-informed perspective to social attunement in Autism Spectrum Disorders (ASD). BACKGROUND: Dance movement therapy (DMT) is a psychotherapeutic intervention that is used with participants with ASD in various settings. Regular clinical outcome monitoring in an outpatient setting in the Netherlands had shown positive effects on social attunement capacities in young people with ASD. However, a systematic study of the development of social attunement movement behaviors of participants with ASD throughout a DMT intervention was not yet available...
March 18, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28335460/neuropsychology-of-aesthetic-judgment-of-ambiguous-and-non-ambiguous-artworks
#16
Maddalena Boccia, Sonia Barbetti, Laura Piccardi, Cecilia Guariglia, Anna Maria Giannini
Several affective and cognitive processes have been found to be pivotal in affecting aesthetic experience of artworks and both neuropsychological as well as psychiatric symptoms have been found to affect artistic production. However, there is a paucity of studies directly investigating effects of brain lesions on aesthetic judgment. Here, we assessed the effects of unilateral brain damage on aesthetic judgment of artworks showing part/whole ambiguity. We asked 19 unilaterally brain-damaged patients (10 left and 9 right brain damaged patients, respectively LBDP and RBDP) and 20 age- and education-matched healthy individuals (controls, C) to rate 10 Arcimboldo's ambiguous portraits (AP), 10 realistic Renaissance portraits (RP), 10 still life paintings (SL), and 10 Arcimboldo's modified portraits where only objects/parts are detectable (AO)...
March 18, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28335450/assessment-of-radioactive-materials-and-heavy-metals-in-the-surface-soil-around-the-bayanwula-prospective-uranium-mining-area-in-china
#17
Haribala Bai, Bitao Hu, Chengguo Wang, Shanhu Bao, Gerilemandahu Sai, Xiao Xu, Shuai Zhang, Yuhong Li
The present work is the first systematic and large scale study on radioactive materials and heavy metals in surface soil around the Bayanwula prospective uranium mining area in China. In this work, both natural and anthropogenic radionuclides and heavy metals in 48 surface soil samples were analyzed using High Purity Germanium (HPGe) γ spectrometry and inductively coupled plasma-mass spectrometry (ICP-MS). The obtained mean activity concentrations of (238)U, (226)Ra, (232)Th, (40)K, and (137)Cs were 25.81 ± 9...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335449/the-relation-between-frequency-of-e-cigarette-use-and-frequency-and-intensity-of-cigarette-smoking-among-south-korean-adolescents
#18
Jung Ah Lee, Sungkyu Lee, Hong-Jun Cho
INTRODUCTION: The prevalence of adolescent electronic cigarette (e-cigarette) use has increased in most countries. This study aims to determine the relation between the frequency of e-cigarette use and the frequency and intensity of cigarette smoking. Additionally, the study evaluates the association between the reasons for e-cigarette use and the frequency of its use. MATERIALS AND METHODS: Using the 2015 Korean Youth Risk Behavior Web-Based Survey, we included 6655 adolescents with an experience of e-cigarette use who were middle and high school students aged 13-18 years...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335447/transcriptomic-complexity-of-aspergillus-terreus-velvet-gene-family-under-the-influence-of-butyrolactone-i
#19
Elina K Palonen, Sheetal Raina, Annika Brandt, Jussi Meriluoto, Tajalli Keshavarz, Juhani T Soini
Filamentous fungi of the Ascomycota phylum are known to contain a family of conserved conidiation regulating proteins with distinctive velvet domains. In Aspergilli, this velvet family includes four proteins, VeA, VelB, VelC and VosA, and is involved in conidiation and secondary metabolism along with a global regulator LaeA. In A. terreus, the overexpression of LaeA has been observed to increase the biogenesis of the pharmaceutically-important secondary metabolite, lovastatin, while the role of the velvet family has not been studied...
March 14, 2017: Microorganisms
https://www.readbyqxmd.com/read/28335445/deciphering-egyptian-hieroglyphs-towards-a-new-strategy-for-navigation-in-museums
#20
Jaime Duque-Domingo, Pedro Javier Herrera, Enrique Valero, Carlos Cerrada
This work presents a novel strategy to decipher fragments of Egyptian cartouches identifying the hieroglyphs of which they are composed. A cartouche is a drawing, usually inside an oval, that encloses a group of hieroglyphs representing the name of a monarch. Aiming to identify these drawings, the proposed method is based on several techniques frequently used in computer vision and consists of three main stages: first, a picture of the cartouche is taken as input and its contour is localized. In the second stage, each hieroglyph is individually extracted and identified...
March 14, 2017: Sensors
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