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https://www.readbyqxmd.com/read/28107746/induced-differentiation-of-human-gingival-fibroblasts-into-vsmc-like-cells
#1
Xuqian Liu, Jie Wang, Fusheng Dong, Hexiang Li, Yali Hou
Vascular smooth muscle cells (VSMCs) are major component of the vascular wall, and they play an essential role in maintaining the basic physiological function and stable structure of the vascular wall. In the present study, human gingival fibroblasts (HGFs) were cultured and induced into VSMC-like cells in vitro to confirm that HGFs with properties of stem cells have the potential for differentiation. The epithelium isolated from patients was extracted from normal human gingiva consisting of epithelium and connective tissue...
January 17, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28107732/comparative-analysis-of-polyamine-metabolism-in-wheat-and-maize-plants
#2
Gabriella Szalai, Katalin Janda, Éva Darkó, Tibor Janda, Violeta Peeva, Magda Pál
In the present work changes in polyamine contents were investigated after various hydroponic polyamine treatments (putrescine, spermidine and spermine at 0.1, 0.3 and 0.5 mM concentrations) in two different crop species, wheat and maize. In contrast to putrescine, higher polyamines (spermidine and spermine) induced concentration-dependent oxidative damage in both crops, resulting in decreased biomass. The unfavourable effects of polyamines were more pronounced in the roots, and maize was more sensitive than wheat...
January 12, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28107731/natural-amelioration-of-zinc-oxide-nanoparticle-toxicity-in-fenugreek%C3%A2-trigonella-foenum-gracum-by-arbuscular-mycorrhizal-glomus-intraradices-secretion-of-glomalin
#3
Narges Ghasemi Siani, Seyfollah Fallah, Lok Raj Pokhrel, Ali Rostamnejadi
Owing to rising production and use of engineered nanoparticles (ENPs) in the myriad of consumer applications, ENPs are being released into the environment where their potential fate and effects have remained unclear. With naturally occurring arbuscular mycorrhizal fungus (AMF; Glomus intraradices) in soils, their influence (positive or negative) on ENPs toxicity in plants is not well documented. Herein, we investigated potential influence of AMF on the growth and development in fenugreek (Trigonella foenum-graecum) under varied Zinc oxide nanoparticles (ZnONPs) treatments (0, 125, 250, 375 and 500 μg g(-1))...
January 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28107719/occurrence-and-elimination-of-antibiotic-resistance-genes-in-a-long-term-operation-integrated-surface-flow-constructed-wetland
#4
Hansun Fang, Qin Zhang, Xiangping Nie, Baowei Chen, Yuandong Xiao, Qiubai Zhou, Wei Liao, Ximei Liang
Wetland construction is a recommended domestic sewage treatment technique, owing to its simplicity and cost efficiency. Concentrations of 14 antibiotic resistance genes (ARGs) in an integrated surface flow constructed wetland (ICW) steadily operated over 10 years were investigated in the winter and summer. Domestic sewage was observed to be the primary source of ARGs in the ICW, and 77.8% and 59.5% removal rates of total targeted ARGs in the ICW were achieved in the winter and summer, respectively. Concentrations of five ARGs (sul1, tetA, tetC, tetE, and qnrS) in the winter and of six ARGs (sul1, sul3, tetA, tetC, tetE, and qnrS) in the summer were increased throughout the treatment process...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28107710/in-vivo-assesment-of-the-genotoxic-and-oxidative-stress-effects-of-particulate-matter-on-echinogammarus-veneris
#5
Melissa Marcoccia, Lucilla Ronci, Elvira De Matthaeis, Andrea Setini, Cinzia Perrino, Silvia Canepari
Seven types of atmospheric dusts (road dust, soil dust, brake dust, desert dust, pellet ash and coke and certified material NIST1648a - urban dust) have been tested for their genotoxicity on specimens of Echinogammarus veneris, a small aquatic amphipod. Experiments were carried out in vivo, by exposing the animals for 24 h to water containing 25 mg/L of dust. Each dust has been chemically analyzed for ions, elemental carbon, organic carbon and for the soluble and insoluble fractions of elements. Non-specific damages to DNA have been evaluated by the comet test, while oxidative damages have been estimated by coupling the comet test with formamido pyrimidine DNA glycosylase reaction...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28107692/rna-binding-protein-msi2-positively-regulates-flt3-expression-in-myeloid-leukemia
#6
Ayuna Hattori, Daniel McSkimming, Natarajan Kannan, Takahiro Ito
FLT3 is frequently mutated and overexpressed in acute myelogenous leukemia (AML) and other hematologic malignancies. Although signaling events downstream of FLT3 receptor tyrosine kinase has been studied in depth, molecular mechanisms of how FLT3 expression is regulated at the post-transcriptional level in particular remain elusive. In this study, we investigated the roles of an RNA binding protein MSI2 as a regulator of FLT3 expression. MSI2 and FLT3 are significantly co-regulated in human AML and chronic myelogenous leukemia in blast crisis (BC-CML)...
January 11, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28107684/non-invasive-brain-stimulation-targeting-the-right-fusiform-gyrus-selectively-increases-working-memory-for-faces
#7
Tad T Brunyé, Joseph M Moran, Amanda Holmes, Caroline R Mahoney, Holly A Taylor
The human extrastriate cortex contains a region critically involved in face detection and memory, the right fusiform gyrus. The present study evaluated whether transcranial direct current stimulation (tDCS) targeting this anatomical region would selectively influence memory for faces versus non-face objects (houses). Anodal tDCS targeted the right fusiform gyrus (Brodmann's Area 37), with the anode at electrode site PO10, and cathode at FP2. Two stimulation conditions were compared in a repeated-measures design: 0...
January 17, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28107680/a-randomized-clinical-trial-of-buprenorphine-for-prisoners-findings-at-12-months-post-release
#8
Michael S Gordon, Timothy W Kinlock, Robert P Schwartz, Kevin E O'Grady, Terrence T Fitzgerald, Frank J Vocci
BACKGROUND: This study examined whether starting buprenorphine treatment prior to prison and after release from prison would be associated with better drug treatment outcomes and whether males and females responded differently to the combination of in-prison treatment and post-release service setting. METHODS: Study design was a 2 (In-Prison Treatment: Condition: Buprenorphine Treatment: vs. Counseling Only)×2 [Post-Release Service Setting Condition: Opioid Treatment: Program (OTP) vs...
January 11, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28107679/meta-analysis-of-the-relationship-between-impulsivity-and-substance-related-cognitive-biases
#9
REVIEW
Daniel Leung, Petra K Staiger, Melissa Hayden, Jarrad A G Lum, Kate Hall, Victoria Manning, Antonio Verdejo-Garcia
BACKGROUND: Evidence indicates that substance-related cognitive biases (attentional, memory, and approach bias) contribute to the maintenance and development of substance misuse. Impulsivity has been suggested to influence how cognitive biases contribute to substance misuse, possibly by biasing incentive salience attribution processes. However, the strength and moderators of the relationship between impulsivity and substance-related cognitive biases has yet to be empirically examined...
January 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28107676/characterization-of-a-new-ultrasound-device-designed-for-measuring-cortical-porosity-at-the-human-tibia-a-phantom-study
#10
M Gräsel, C-C Glüer, R Barkmann
Quantitative ultrasound (QUS) measurements of trabecular bone are a useful tool for the assessment of osteoporotic fracture risk. However, cortical bone properties (e.g. porosity) have an impact on bone strength as well and thus current research is focused on QUS assessment of cortical bone properties. Simulation studies of ultrasound propagation through cortical bone indicate that anisotropy, calculated from the ratio of the velocities in axial and tangential directions, is correlated with porosity. However, this relationship is affected by error sources, specifically bone surface curvature and variability of probe positioning...
January 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28107674/mitochondrial-serine-hydroxymethyltransferase-2-is-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#11
Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang
OBJECTIVE: Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients...
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28107671/recent-sequence-variation-in-probe-binding-site-affected-detection-of-respiratory-syncytial-virus-group-b-by-real-time-rt-pcr
#12
Everlyn Kamau, Charles N Agoti, Clement S Lewa, John Oketch, Betty E Owor, Grieven P Otieno, Anne Bett, Patricia A Cane, D James Nokes
BACKGROUND: Direct immuno-fluorescence test (IFAT) and multiplex real-time RT-PCR have been central to RSV diagnosis in Kilifi, Kenya. Recently, these two methods showed discrepancies with an increasing number of PCR undetectable RSV-B viruses. OBJECTIVES: Establish if mismatches in the primer and probe binding sites could have reduced real-time RT-PCR sensitivity. STUDY DESIGN: Nucleoprotein (N) and glycoprotein (G) genes were sequenced for real-time RT-PCR positive and negative samples...
January 5, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28107655/discrimination-between-naphthacene-and-triphenylene-using-cellulose-tris-4-methylbenzoate-and-cellulose-tribenzoate-a-computational-study
#13
Yusuke Murakami, Tohru Shibata, Kazuyoshi Ueda
The mechanisms of naphthacene and triphenylene discrimination using commercially available cellulose tris(4-methylbenzoate) (CMB) and cellulose tribenzoate (CB) chiral stationary phases were investigated using molecular mechanics calculations. Naphthacene and triphenylene could be separated by liquid chromatography on CMB and CB, with triphenylene being eluted earlier than naphthacene on both phases. However, the corresponding separation factor is much larger for CMB than for CB. The docking of these polycyclic aromatic hydrocarbons to the above polymers suggested that the most important sites of CMB and CB for interacting with these hydrocarbons are located at equivalent positions, featuring a space surrounded by main chain glucose units and benzoyl side chains...
January 7, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28107643/does-psychological-well-being-change-following-treatment-an-exploratory-study-on-outpatients-with-eating-disorders
#14
Elena Tomba, Lucia Tecuta, Romana Schumann, Donatella Ballardini
Psychological well-being changes following cognitive-behavioral therapy-based treatment were investigated in outpatients with eating disorders (ED). While it is known that CBT reduces symptomatology in EDs, less is known about how changes in positive functioning may ensue. One-hundred and eighty five ED outpatients were analyzed for pre-treatment and post-treatment changes in psychological well-being (PWB) by last observation carried forward - Wilcoxon signed rank tests. Significant gains in all PWB dimensions were found, with moderate effect size correlations in environmental mastery (r=-...
January 7, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28107623/dna-advanced-glycation-end-products-dna-ages-are-elevated-in-urine-and-tissue-in-an-animal-model-of-type-2-diabetes
#15
Richard Jaramillo, Sarah C Shuck, Yin S Chan, Xueli Liu, Steven E Bates, Punnajit P Lim, Daniel Tamae, Sandrine Lacoste, Timothy R O'Connor, John Stephen Termini
More precise identification and treatment monitoring of prediabetic/diabetic individuals will require additional biomarkers to complement existing diagnostic tests. Candidates include hyperglycemia-induced adducts such as advanced glycation end products (AGEs) of proteins, lipids, and DNA. The potential for DNA-AGEs as diabetic biomarkers was examined in a longitudinal study using the Leprdb/db animal model of metabolic syndrome. The DNA-AGE, N2-(1-carboxyethyl)-2´-deoxyguanosine (CEdG) was quantified by mass spectrometry using isotope dilution from urine and tissue of hyperglycemic and normoglycemic mice...
January 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28107614/sirt1-dependent-anti-senescence-effects-of-cell-deposited-matrix-on-human-umbilical-cord-mesenchymal-stem-cells
#16
Long Zhou, Xi Chen, Tao Liu, Caihong Zhu, Michelle Si, Joseph Jargstorf, Mao Li, Guoqing Pan, Yihong Gong, Zong-Ping Luo, Huilin Yang, Ming Pei, Fan He
Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are considered an attractive cell source for tissue regeneration. However, environmental oxidative stress can trigger premature senescence in MSCs and thus compromises their regenerative potential. Extracellular matrix (ECM) derived from MSCs has been shown to facilitate cell proliferation and multilineage differentiation. This investigation evaluated the effect of cell-deposited decellularized ECM (DECM) on oxidative stress-induced premature senescence in UC-MSCs...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28107611/adaptation-and-validation-of-the-singing-voice-handicap-index-into-polish
#17
Ewelina M Sielska-Badurek, Maria Sobol, Anna Cioch, Ewa Osuch-Wójcikiewicz, Anna M Rzepakowska, Kazimierz Niemczyk
OBJECTIVE: To translate and adapt the original SVHI for the Polish population and to evaluate the psychometric properties of the Polish SVHI version, such as internal consistency, reliability and construct validity in different groups of dysphonic singers. STUDY DESIGN: Prospective case-control study. SETTING: Patients treated at a single institute. PARTICIPANTS: 60 singers with voice disorders and 57 healthy singers completed the Singing Voice Handicap Index (SVHI) and the Voice Handicap Index (VHI)...
January 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28107607/epidemiology-update-for-hepatitis-c-virus-and-hepatitis-b-virus-in-end-stage-renal-disease-in-france-r%C3%A3-seau-epid%C3%A3-miologique-et-information-en-n%C3%A3-phrologie-registry
#18
Corinne Isnard Bagnis, Cécile Couchoud, Marc Bowens, Ayman Sarraj, Gilbert Deray, Jérôme Tourret, Patrice Cacoub, Sophie Tezenas du Montcel
BACKGROUND AND AIMS: Risk for HCV/HBV infection is increased in ESRD patients. We generate updated epidemiological data. METHODS: Based on the National French registry for ESRD, we extracted data for patients who started dialysis or preemptive transplantation between January, 2005 and December, 2013. A positive serum HBs Ag and/or a positive HCV RNA defined HBV and HCV infections, respectively. RESULTS: 72,948 patients were included among which 62...
January 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28107606/dishevelled-segment-polarity-protein-3-dvl3-a-novel-and-easily-applicable-recurrence-predictor-in-localized-prostate-adenocarcinoma
#19
Pil-Jong Kim, Ji Y Park, Hong-Gee Kim, Yong Mee Cho, Heounjeong Go
OBJECTIVE: To identify new biomarkers for the biochemical recurrence (BCR) of prostate adenocarcinoma. PATIENTS AND METHODS: Clinical information of 500 prostate adenocarcinoma patients and their 152 RNA-sequencing and protein-array data from The Cancer Genome Atlas (TCGA) were separated into a discovery-set and a validation-set. Each dataset was analyzed according to the Gleason grade groups reflecting BCR. The results obtained from the analysis using TCGA dataset were confirmed by immunohistochemistry analyses of the confirmation cohort composed of 395 localized prostate adenocarcinoma patients...
January 20, 2017: BJU International
https://www.readbyqxmd.com/read/28107601/predictors-of-liver-histological-changes-and-a-sustained-response-to-peginterferon-among-chronic-hepatitis-b-e-antigen-positive-patients-with-normal-or-minimally-elevated-alanine-aminotransferase-levels
#20
Jie Chen, Cheng-Run Xu, Min Xi, Wei-Wei Hu, Zheng-Hao Tang, Guo-Qing Zhang
BACKGROUND: A proportion of chronic hepatitis B (CHB) patients with normal or only minimally elevated ALT levels display significant histologic changes, and would benefit from antiviral therapy. OBJECTIVES: We aim to evaluate the histologic abnormalities seen in these patients, and then determine which of them would most likely respond to peginterferon therapy. METHODS: One hundred and thirteen hepatitis B e antigen (HBeAg)-positive patients with a normal or minimally elevated ALT level and moderate to severe histologic changes in their liver tissue were selected to receive peginterferon monotherapy and participate in a followup analysis...
January 20, 2017: Journal of Viral Hepatitis
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