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https://www.readbyqxmd.com/read/28432978/cadmium-hampers-salt-tolerance-of-sesuvium-portulacastrum
#1
Mariem Wali, Soledad Martos, Laura Pérez-Martín, Chedly Abdelly, Tahar Ghnaya, Charlotte Poschenrieder, Benet Gunsé
It is well known that salinity reduces cadmium toxicity in halophytes. However, the possible interference of Cd with the mechanisms of salt tolerance is poorly explored. The aim of this study was to see whether Cd affects salt tolerance mechanisms in the halophyte Sesuvium portulacastrum. S. portulacastrum plants obtained from cuttings were grown in hydroponics for 3 weeks and then exposed to low (0.09 mM) or moderate (200 mM) NaCl concentrations, alone or in combination with 25 μM CdCl2. Microscopy observation revealed two strategies of salt tolerance: euhalophytism and secretion of salt by bladder cells...
April 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28432789/probing-protein-flexibility-reveals-a-mechanism-for-selective-promiscuity
#2
Nicolas A Pabon, Carlos J Camacho
Many eukaryotic regulatory proteins adopt distinct bound and unbound conformations, and use this structural flexibility to bind specifically to multiple partners. However, we lack an understanding of how an interface can select some ligands, but not others. Here, we present a molecular dynamics approach to identify and quantitatively evaluate the interactions responsible for this selective promiscuity. We apply this approach to the anti-cancer target PD-1 and its ligands PD-L1 and PD-L2. We discover that while unbound PD-1 exhibits a hard-to-drug hydrophilic interface, conserved specific triggers encoded in the cognate ligands activate a promiscuous binding pathway that reveals a flexible hydrophobic binding cavity...
April 22, 2017: ELife
https://www.readbyqxmd.com/read/28432739/effect-of-a-4-week-elastic-resistance-band-training-regimen-on-back-kinematics-in-horses-trotting-in-hand-and-on-the-lunge
#3
T Pfau, V Simons, N Rombach, N Stubbs, R Weller
REASONS FOR PERFORMING STUDY: Training and rehabilitation techniques aiming at improving core muscle strength may result in increased dynamic stability of the equine vertebral column. A system of elastic resistance bands is suggested to provide proprioceptive feedback during motion to encourage recruitment of core abdominal and hindquarter musculature for improved dynamic stability. OBJECTIVES: To quantify the effects of a specific resistance band system on back kinematics during trot in-hand and during lungeing at beginning and end of a 4-week exercise programme...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28432211/recruiting-and-retaining-youth-and-young-adults-challenges-and-opportunities-in-survey-research-for-tobacco-control
#4
Jennifer Cantrell, Elizabeth C Hair, Alexandria Smith, Morgane Bennett, Jessica Miller Rath, Randall K Thomas, Mansour Fahimi, J Michael Dennis, Donna Vallone
INTRODUCTION: Evaluation studies of population-based tobacco control interventions often rely on large-scale survey data from numerous respondents across many geographic areas to provide evidence of their effectiveness. Significant challenges for survey research have emerged with the evolving communications landscape, particularly for surveying hard-to-reach populations such as youth and young adults. This study combines the comprehensive coverage of an address-based sampling (ABS) frame with the timeliness of online data collection to develop a nationally representative longitudinal cohort of young people aged 15-21...
April 21, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28431560/a-new-generation-of-bacillus-subtilis-cell-factory-for-further-elevated-scyllo-inositol-production
#5
Kosei Tanaka, Ayane Natsume, Shu Ishikawa, Shinji Takenaka, Ken-Ichi Yoshida
BACKGROUND: A stereoisomer of inositol, scyllo-inositol (SI), has been regarded as a promising therapeutic agent for Alzheimer's disease. However, this compound is relatively rare, whereas another stereoisomer of inositol, myo-inositol (MI) is abundant in nature. Bacillus subtilis 168 has the ability to metabolize inositol stereoisomers, including MI and SI. Previously, we reported a B. subtilis cell factory with modified inositol metabolism that converts MI into SI in the culture medium...
April 21, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28431552/strategies-to-improve-engagement-of-hard-to-reach-older-people-in-research-on-health-promotion-a-systematic-review
#6
Ann E M Liljas, Kate Walters, Ana Jovicic, Steve Iliffe, Jill Manthorpe, Claire Goodman, Kalpa Kharicha
BACKGROUND: This systematic review aimed to identify facilitators, barriers and strategies for engaging 'hard to reach' older people in research on health promotion; the oldest old (≥80 years), older people from black and minority ethnic groups (BME) and older people living in deprived areas. METHODS: Eight databases were searched to identify eligible studies using quantitative, qualitative, and mixed research methods. Using elements of narrative synthesis, engagement strategies, and reported facilitators and barriers were identified, tabulated and analysed thematically for each of the three groups of older people...
April 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28431515/the-effectiveness-of-creating-an-online-life-story-book-on-persons-with-early-dementia-and-their-informal-caregivers-a-protocol-of-a-randomized-controlled-trial
#7
Teuntje R Elfrink, Sytse U Zuidema, Miriam Kunz, Gerben J Westerhof
BACKGROUND: Dementia has a high burden for patients, informal caregivers and society. Given changes in care systems, more persons with dementia will live longer at home. However, living at home (with dementia) with a good quality of life is not easy to achieve. Dementia is often accompanied by neuropsychiatric symptoms like apathy, agitation, depression, and anxiety, which have a negative impact on quality of life. Whereas cognitive deterioration can hardly be influenced, it is possible to reduce neuropsychiatric symptoms...
April 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28431507/antimicrobial-prophylaxis-outside-the-operating-theatre-an-audit-in-a-university-hospital
#8
Jan W T Deelen, Caroline E Visser, Jan M Prins, Reinier M van Hest
BACKGROUND: The prophylactic use of antimicrobial agents to prevent infections in non-surgical situations has hardly been investigated. We investigate the extent, indications and appropriateness of antimicrobial prophylaxis given outside the operating room in a tertiary care hospital. METHODS: Four point-prevalence surveys were conducted in which all inpatients on that day were screened for the use of prophylactic antimicrobials: medical prophylaxis, prophylaxis around non-surgical interventions and surgical prophylaxis given on the ward...
April 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28431500/foot-length-chest-and-head-circumference-measurements-in-detection-of-low-birth-weight-neonates-in-mekelle-ethiopia-a-hospital-based-cross-sectional-study
#9
Marta Yemane Hadush, Amanuel Hadgu Berhe, Araya Abrha Medhanyie
BACKGROUND: Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve their chance of survival. However, a large proportion of births in developing countries take place at home and birth weight statistics are not available. Therefore, there is a need to develop simple, inexpensive and practical methods to identify low birth weight (LBW) neonates soon after birth...
April 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28431491/fluoride-varnishes-containing-sodium-trimetaphosphate-reduce-enamel-demineralization-in-vitro
#10
Michele M Manarelli, Alberto C B Delbem, Liliana Carolina Báez-Quintero, Felipe Ricardo N de Moraes, Robson F Cunha, Juliano P Pessan
OBJECTIVE: This study evaluated the effects of fluoride varnishes containing sodium trimetaphosphate (TMP) on bovine enamel demineralization in vitro. MATERIAL AND METHODS: Enamel bovine discs were randomly assigned into six groups (n = 20/group): placebo, 2.5% NaF, 2.5% NaF/5% TMP, 5% NaF, 5% NaF/5% TMP, and a commercial formulation (Duraphat, 5% NaF). Varnishes were applied on all enamel discs and kept for 6 h. Loosely and firmly bound fluoride formed on/in enamel after treatment were analyzed in 10 discs from each group...
April 21, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28431206/phase-transfer-ligand-exchange-of-lead-chalcogenide-quantum-dots-for-direct-deposition-of-thick-highly-conductive-films
#11
Qianglu Lin, Hyeong Jin Yun, Wenyong Liu, Hyung-Jun Song, Nikolay S Makarov, Oleksandr Isaienko, Tom Nakotte, Gen Chen, Hongmei Luo, Victor I Klimov, Jeffrey M Pietryga
The use of semiconductor nanocrystal quantum dots (QDs) in optoelectronic devices typically requires post-synthetic chemical surface treatments to enhance electronic coupling between QDs and allow for efficient charge transport in QD films. Despite their importance to solar cells, and infrared (IR) light-emitting diodes and photodetectors, advances in these chemical treatments for lead chalcogenide (PbE, E = S, Se, Te) QDs have lagged behind those of, for instance, II-VI semiconductor QDs. Here, we introduce a method for fast and effective ligand exchange for PbE QDs in solution, resulting in QDs completely passivated by a wide range of small anionic ligands...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28430250/tolerancing-the-alignment-of-large-core-optical-fibers-fiber-bundles-and-light-guides-using-a-fourier-approach
#12
Travis W Sawyer, Ryan Petersburg, Sarah E Bohndiek
Optical fiber technology is found in a wide variety of applications to flexibly relay light between two points, enabling information transfer across long distances and allowing access to hard-to-reach areas. Large-core optical fibers and light guides find frequent use in illumination and spectroscopic applications, for example, endoscopy and high-resolution astronomical spectroscopy. Proper alignment is critical for maximizing throughput in optical fiber coupling systems; however, there currently are no formal approaches to tolerancing the alignment of a light-guide coupling system...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429875/effect-of-untreated-zirconium-oxide-nanofiller-on-the-flexural-strength-and-surface-hardness-of-autopolymerized-interim-fixed-restoration-resins
#13
Abdolhamid Alhavaz, Maryam Rezaei Dastjerdi, Arman Ghasemi, Azade Ghasemi, Abolfazl Alizadeh Sahraei
OBJECTIVE: Autopolymerized poly methyl methacrylate (PMMA) resin is commonly used for the construction of interim restorations; however, it has less than optimal mechanical properties. In this article, we evaluated the reinforcing effect of adding untreated zirconia nanoparticles on the flexural strength and surface hardness of this resin. METHODS: A total of 80 specimens were fabricated. Forty each were used for the flexural strength test and for the surface hardness test...
April 21, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28429732/long-term-stability-and-infectivity-of-herpesviruses-in-water
#14
Anisha Dayaram, Mathias Franz, Alexander Schattschneider, Armando M Damiani, Sebastian Bischofberger, Nikolaus Osterrieder, Alex D Greenwood
For viruses to utilize environmental vectors (hard surfaces, soil, water) for transmission, physical and chemical stability is a prerequisite. There are many factors including pH, salinity, temperature, and turbidity that are known to contribute to the ability of viruses to persist in water. Equine herpesvirus type-1 (EHV-1) is a pathogenic alphaherpesvirus associated with domestic horses and wild equids. EHV-1 and recombinants of EHV-1 and EHV-9 are able to cause infections in non-equid animal species, particularly in captive settings...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429550/parathyroid-hormone-targets-in-chronic-kidney-disease-and-managing-severe-hyperparathyroidism
#15
Carmel M Hawley, Stephen G Holt
Appropriate targets for parathyroid hormone (PTH) in patients with chronic kidney disease (CKD) stages 3-5D are controversial, as are the means by which these targets might be achieved. Secondary hyperparathyroidism is linked to symptoms like bone pain and itch, in addition to less clinically overt issues like bone fragility as well as vascular and soft tissue calcification which may lead to adverse hard endpoints, particularly fracture and death. Recognized therapies for managing a rising PTH include vitamin D analogues, with or without calcimimetic (where available), in addition to management of serum mineral concentrations with diet, binders and dialysis...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28429482/the-periodontal-restorative-interface-esthetic-considerations
#16
REVIEW
Vincent Bennani, Hadeel Ibrahim, Latfiya Al-Harthi, Karl M Lyons
Esthetic considerations are a significant contributing factor in the management of prosthodontic cases and an interdisciplinary approach is often necessary to achieve an optimal result. The visible soft-tissue architecture plays a key role in developing an esthetic smile. Furthermore, an understanding of the relationship between the restorative margin and the gingiva is important for long-term stability of the result. The gingival architecture and gingival health are important for ensuring optimal esthetics following prosthodontic work and close attention to both soft and hard tissues around the teeth, before, during and after restorative procedures, will greatly improve the likelihood of a successful outcome...
June 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28429394/immediate-implant-placement-and-restoration-in-the-anterior-maxilla-tissue-dimensional-changes-after-2-5-year-follow-up
#17
Himanshu Arora, Nabil Khzam, David Roberts, William L Bruce, Saso Ivanovski
BACKGROUND: Immediate implant placement followed by an immediate restoration has proven to be a viable technique in the anterior maxillary region. PURPOSE: This prospective study evaluated the mid-long term (2-5 years) tissue changes around immediately placed and restored implants in the anterior maxilla using flapless surgery and simultaneous hard tissue augmentation. MATERIALS AND METHODS: Thirty AstraTech implants were immediately placed in 30 patients, followed by the delivery of an immediate provisional restoration on the same day...
April 21, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28429313/gradually-shrinking-intra-abdominal-desmoid-tumor-derived-from-the-stomach-in-a-young-boy-a-case-report
#18
Kazushi Miyata, Masahide Fukaya, Masato Nagino
BACKGROUND: Intra-abdominal desmoid tumors, particularly those derived from the stomach, are rare. Such tumors are associated with a history of familial adenomatous polyposis (FAP), trauma, or surgical procedures in general. In addition, spontaneous shrinking of an intra-abdominal desmoid tumor is rarer. And desmoid tumors most commonly arise during the fourth decade of life. CASE PRESENTATION: A 17-year-old boy with lower abdominal pain was diagnosed with a gastrointestinal stromal tumor (GIST) or a hematoma at a local hospital...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28429301/ethical-issues-related-to-the-promotion-of-a-100-msv-threshold-assumption-in-japan-after-the-fukushima-nuclear-accident-in-2011-background-and-consequences
#19
REVIEW
Toshihide Tsuda, Lena Lindahl, Akiko Tokinobu
PURPOSE OF REVIEW: This article describes the debates in Japan regarding the 100 mSv threshold assumption and ethical issues related to it, and explores the background to distorted risk information and absence of risk communication in Japan. Then we seek proper risk communication based on scientific evidence. RECENT FINDINGS: On March 11, 2011 an accident occurred at the Fukushima Daiichi Nuclear Power Plant due to the Great East Japan Earthquake. Since then a number of misunderstandings have become common in Japan as a result of public statements by the Japanese and local governments that have no basis in medical science or are contradictory to medical science...
April 20, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28429120/the-influence-of-pump-rotation-speed-on-hemodynamics-and-myocardial-oxygen-metabolism-in-left-ventricular-assist-device-support-with-aortic-valve-regurgitation
#20
Kei Iizuka, Tomohiro Nishinaka, Yoshiaki Takewa, Kenji Yamazaki, Eisuke Tatsumi
Aortic valve regurgitation (AR) is a serious complication under left ventricular assist device (LVAD) support. AR causes LVAD-left ventricular (LV) recirculation, which makes it difficult to continue LVAD support. However, the hemodynamics and myocardial oxygen metabolism of LVAD support with AR have not been clarified, especially, how pump rotation speed influences them. An animal model of LVAD with AR was newly developed, and how pump rotation speed influences hemodynamics and myocardial oxygen metabolism was examined in acute animal experiments...
April 20, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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