keyword
MENU ▼
Read by QxMD icon Read
search

Hard

keyword
https://www.readbyqxmd.com/read/29684936/the-relationship-between-hard-tissue-and-soft-tissue-dimensions-of-the-nose-in-children-a-3d-cone-beam-computed-tomography-study
#1
Eman Allam, Philani Mpofu, Ahmed Ghoneima, Mihran Tuceryan, Katherine Kula
This study using three-dimensional cone beam computed tomography (CBCT) images of children determined relationships between nasal skeletal and soft tissue measurements and assessed the association with sex, age, and skeletal maturation stage. Following reliability studies, skeletal and soft tissue parameters were measured on coded CBCTs of 73 children (28M:45F;6-13 yoa). Pearson and Mantel correlations were used to analyze associations between skeletal and soft tissues. Partial Mantel correlations were used to study the associations between skeletal and soft tissue, adjusting for sex, age, and skeletal maturation...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684908/chemometrics-assisted-investigation-of-interactions-of-tasmar-with-human-serum-albumin-at-a-glassy-carbon-disk-application-to-electrochemical-biosensing-of-electro-inactive-serum-albumin
#2
Ghobad Mohammadi, Elahe Faramarzi, Majid Mahmoudi, Sirous Ghobadi, Ali Reza Ghiasvand, Hector C Goicoechea, Ali R Jalalvand
In this work, voltammetric data recorded by a glassy carbon electrode (GCE) was used to investigate the interactions of tolcapone (Tasmar, TAS) with human serum albumin (HSA) at the electrode surface. The recorded voltammetric data was also combined with spectroscopic data to construct an augmented data matrix which was analysed by multivariate curve resolution-alternating least squares (MCR-ALS) as an efficient chemometric tool to obtain more information about TAS-HSA interactions. The results of MCR-ALS confirmed formation of one complex species (HSA-TAS2 ) and application of MCR-BANDS to the results of MCR-ALS confirmed the absence of rotational ambiguities and existing unambiguous and reliable results...
April 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#3
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684584/deletion-of-epithelial-cell-specific-cdc42-leads-to-enamel-hypermaturation-in-a-conditional-knockout-mouse-model
#4
Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang, Buling Wu, Lin Zhang
Recent evidence suggests that GTPases Rho family plays an important role in tooth development; however, the role of Cdc42 in tooth development remains unclear. We aimed to investigate the function of Cdc42 in tooth development and amelogenesis. We generated an epithelial cell-specific K5-Cdc42 knockout (KO) mouse to evaluate post-eruption dental phenotypes using a K5-Cre driver line. This model overcomes the previously reported perinatal lethality. Tooth phenotypes were analyzed by micro X-ray, micro-computed tomography (CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), wear rate, shear strength, and a microhardness test...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684559/a-novel-approach-to-support-formulation-design-on-twin-screw-wet-granulation-technology-understanding-the-impact-of-overarching-excipient-properties-on-drug-product-quality-attributes
#5
N Willecke, A Szepes, M Wunderlich, J P Remon, C Vervaet, T De Beer
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based formulation design and formulation optimization. Three principal components which represent the overarching properties of 8 selected pharmaceutical fillers were used as factors, whereas factors 4 and 5 represented binder type and binder concentration in a design of experiments (DoE)...
April 20, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29684533/lipid-coated-mannitol-core-microparticles-for-sustained-release-of-protein
#6
Bifeng Wang, Wolfgang Friess
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different coating levels...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684494/quality-assessment-and-artificial-neural-networks-modeling-for-characterization-of-chemical-and-physical-parameters-of-potable-water
#7
Marjan Salari, Esmail Salami, Seyed Hossein Afzali, Majid Ehteshami, Gea Oliveri Conti, Zahra Derakhshan, Solmaz Nikbakht Sheibani
Today, due to the increase in the population, the growth of industry and the variety of chemical compounds, the quality of drinking water has decreased. Five important river water quality properties such as: dissolved oxygen (DO), total dissolved solids (TDS), total hardness (TH), alkalinity (ALK) and turbidity (TU) were estimated by parameters such as: electric conductivity (EC), temperature (T), and pH that could be measured easily with almost no costs. Simulate water quality parameters were examined with two methods of modeling include mathematical and Artificial Neural Networks (ANN)...
April 20, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29684363/immunolabeling-of-cleared-human-pancreata-provides-insights-into-three-dimensional-pancreatic-anatomy-and-pathology
#8
Michaël Noë, Neda Rezaee, Kaushal Asrani, Michael Skaro, Vincent P Groot, Pei-Hsun Wu, Matthew T Olson, Seung-Mo Hong, Sung Joo Kim, Matthew J Weiss, Christopher L Wolfgang, Martin A Makary, Jin He, John L Cameron, Denis Wirtz, Nicholas J Roberts, G Johan A Offerhaus, Lodewijk A A Brosens, Laura D Wood, Ralph H Hruban
Visualizing pathologies in three dimensions (3D) can provide unique insights into the biology of human diseases. A rapid and easy-to-implement dibenzyl ether-based technique was used to clear thick sections of surgically resected human pancreatic parenchyma. Protocols were applicable to both fresh and formalin-fixed paraffin-embedded tissue. The penetration of antibodies into dense pancreatic parenchyma was optimized using both gradually increasing antibody concentrations and centrifugal flow. Immunolabeling with antibodies against CK19 was visualized using both light sheet and confocal laser scanning microscopy...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684061/the-kinetics-of-tem1-antibiotic-degrading-enzymes-that-are-displayed-on-ure2-protein-nanofibrils-in-a-flow-reactor
#9
Benjamin Schmuck, Mats Sandgren, Torleif Härd
Enzymatic functionalization of cross-β structured protein nanofibrils has hitherto resulted in a severe reduction of the catalytic efficiency of high turnover biocatalysts. It has been speculated that steric restrictions and mass transport pose limits on the attached enzymes, but detailed kinetics analyzing this have not yet been reported. For a more comprehensive understanding, we studied protein nanofibrils endowed with TEM1, a β-lactamase from Escherichia coli. The packing density of TEM1 along the fibrils was controlled by co-fibrillation; in other words, the N-terminal ureidosuccinate transporter Ure2(1-80) from Saccharomyces cerevisiae was simultaneously aggregated with the chimeric proteins TEM1-Ure2(1-80)...
2018: PloS One
https://www.readbyqxmd.com/read/29683174/percolation-of-functionalized-colloids-on-patterned-substrates
#10
Lucas L Treffenstädt, Nuno A M Araújo, Daniel de Las Heras
We study the percolation properties for a system of functionalized colloids on patterned substrates via Monte Carlo simulations. The colloidal particles are modeled as hard disks with three equally-distributed attractive patches on their perimeter. We describe the patterns on the substrate as circular potential wells of radius Rp arranged in a regular square or hexagonal lattice. We find a nonmonotonic behavior of the percolation threshold (packing fraction) as a function of Rp. For attractive wells, the percolation threshold is higher than the one for clean (non-patterned) substrates if the circular wells are non-overlapping and can only be lower if the wells overlap...
April 23, 2018: Soft Matter
https://www.readbyqxmd.com/read/29683154/growth-of-ni-nanoclusters-on-irradiated-graphene-a-molecular-dynamics-study
#11
F J Valencia, E E Hernandez-Vazquez, E M Bringa, J L Moran-Lopez, J Rogan, R I Gonzalez, F Munoz
We studied the soft landing of Ni atoms on a previously damaged graphene sheet by means of molecular dynamics simulations. We found a monotonic decrease of the cluster frequency as a function of its size, but few big clusters comprise an appreciable fraction of the total number of Ni atoms. The aggregation of Ni atoms is also modeled by means of a simple phenomenological model. The results are in clear contrast with the case of hard or energetic landing of metal atoms, where there is a tendency to form mono-disperse metal clusters...
April 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29683009/the-recaptcha-of-medical-education
#12
Sean Tackett, Shiv Gaglani, James Heilman, Amin Azzam
This article focuses on what Luis von Ahn called the "twofer," that is, a single solution that elegantly addresses two problems on a large scale. We describe two of von Ahn's creations: reCAPTCHA, which validates a human web presence while also digitizing hard-to-read words, and Duolingo, which teaches new languages while translating the web. We then consider how this approach can be applied to medical education. Embedding Wikipedia-editing into educational settings is one such solution that could both improve the quality of health information available to the public while enhancing the learning of future health professionals...
April 22, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29682688/what-is-the-benefit-of-using-amniotic-membrane-in-oral-surgery-a-comprehensive-review-of-clinical-studies
#13
REVIEW
M Fénelon, S Catros, J C Fricain
OBJECTIVES: Since its first use for the reconstruction of tissue defects in the oral cavity in 1985, human amniotic membrane (hAM) has been widely studied in the field of oral surgery. Despite the growing number of publications in this field, there is no systematic review or meta-analysis concerning its clinical applications, outcome assessments, and relevance in oral surgery. The aim of this review is to provide a thorough understanding of the potential use of hAM for soft and hard tissue reconstruction in the oral cavity...
April 22, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29682646/effects-of-surface-roughness-on-the-self-diffusion-dynamics-of-a-single-polymer
#14
Jiaxiang Li, Mingming Ding, Ran Zhang, Tongfei Shi
We employ molecular dynamics simulations to simulate the diffusion dynamics of a single polymer adsorbed on surfaces with different roughnesses, which are characterized by the separation distance between obstacles and the height of obstacles. Our simulations demonstrate that for strong adsorption and when the confinement of obstacles is strong enough for all chains, the scaling exponent α of the diffusion coefficient on the chain length exhibits three cases with increase of the height of obstacles: a Rouse plateau with α ≈ -1 (the lateral motion of the polymer chains is free), a reptationlike plateau with α ≈ -1...
April 23, 2018: Soft Matter
https://www.readbyqxmd.com/read/29682436/metastatic-sternal-osteosarcoma-a-rare-tumor
#15
Muhammad Masab, Ena Arora, Sorab Gupta, Hafsa Farooq, Vishal Jindal, Shorabh Sharma
Osteosarcoma is the most common primary malignant tumor of the long bones. However, primary osteosarcoma of the chest wall, particularly the sternum, is an extremely rare occurrence. We report a 36-year-old male presenting with a hard, immobile, palpable, anterior chest wall mass. A computed tomographic (CT) scan showed a large destructive anterior mediastinal mass involving the manubrium and sternum with multiple bilateral calcified lung masses, pleural effusions and partially calcified aortopulmonary, right hilar and subcarinal lymphadenopathy...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29682316/physical-properties-of-the-tunic-in-the-pinkish-brown-salp-pegea-confoederata-tunicata-thaliacea
#16
Daisuke Sakai, Hiroshi Kakiuchida, Jun Nishikawa, Euichi Hirose
Background: Invisibility in the water column is a crucial strategy for gelatinous zooplanktons in avoiding detection by visual predators, especially for animals distributed in the euphotic zone during the daytime; i.e., surface dwellers that do not undergo diel vertical migration. Salps, a member of the subphylum Tunicata (Urochordata), usually have a transparent body that is entirely covered with a cellulosic matrix, called the tunic. Some non-migrator species are known to exhibit a nano-scale nipple array on the tunic surface...
2018: Zoological Letters
https://www.readbyqxmd.com/read/29681897/population-genetic-structure-of-listeria-monocytogenes-strains-isolated-from-the-pig-and-pork-production-chain-in-france
#17
Benjamin Félix, Carole Feurer, Aurelien Maillet, Laurent Guillier, Evelyne Boscher, Annaëlle Kerouanton, Martine Denis, Sophie Roussel
Listeria monocytogenes is an ubiquitous pathogenic bacterium, transmissible to humans through the consumption of contaminated food. The pork production sector has been hit hard by a series of L. monocytogenes -related food poisoning outbreaks in France. An overview of the diversity of strains circulating at all levels of the pork production chain, from pig farming (PF) to finished food products (FFP), is needed to identify the contamination routes and improve food safety. Until now, no typing data has been available on strains isolated across the entire pig and pork production chain...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29681653/photonic-resins-designing-optical-appearance-via-block-copolymer-self-assembly
#18
Dong-Po Song, Gianni Jacucci, Feyza Dundar, Aditi Naik, Hua-Feng Fei, Silvia Vignolini, James J Watkins
Despite a huge variety of methodologies having been proposed to produce photonic structures by self-assembly, the lack of an effective fabrication approach has hindered their practical uses. These approaches are typically limited by the poor control in both optical and mechanical properties. Here we report photonic thermosetting polymeric resins obtained through brush block copolymer (BBCP) self-assembly. We demonstrate that the control of the interplay between order and disorder in the obtained photonic structure offers a powerful tool box for designing the optical appearance of the polymer resins in terms of reflected wavelength and scattering properties...
March 27, 2018: Macromolecules
https://www.readbyqxmd.com/read/29681631/management-of-medical-care-a-fundamental-tool-for-resident-doctors
#19
Guillermo Fajardo-Ortiz, Héctor Robledo
In the area of medical education, and particularly in our country, medical residencies are the best educational programs for a graduated physicians; however, when young medical doctors begin a residence at hospitals, they hardly poses knowledge about the way medical services work as well as the processes they involve, which directly affects the fulfillment of their tasks, their process of learning and more importantly, it interferes in the services provided by the hospital. Therefore, it is imperative to immerse residents in the management of medical care and let them know that its main function is to harmoniously articulate every medical-administrative process related to patients as well as human, material and financial resources...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29681541/differentiation-of-human-pluripotent-stem-cells-into-functional-endothelial-cells-in-scalable-suspension-culture
#20
Ruth Olmer, Lena Engels, Abdulai Usman, Sandra Menke, Muhammad Nasir Hayat Malik, Frank Pessler, Gudrun Göhring, Dorothee Bornhorst, Svenja Bolten, Salim Abdelilah-Seyfried, Thomas Scheper, Henning Kempf, Robert Zweigerdt, Ulrich Martin
Endothelial cells (ECs) are involved in a variety of cellular responses. As multifunctional components of vascular structures, endothelial (progenitor) cells have been utilized in cellular therapies and are required as an important cellular component of engineered tissue constructs and in vitro disease models. Although primary ECs from different sources are readily isolated and expanded, cell quantity and quality in terms of functionality and karyotype stability is limited. ECs derived from human induced pluripotent stem cells (hiPSCs) represent an alternative and potentially superior cell source, but traditional culture approaches and 2D differentiation protocols hardly allow for production of large cell numbers...
April 17, 2018: Stem Cell Reports
keyword
keyword
1159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"