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https://www.readbyqxmd.com/read/28636272/development-of-biotic-ligand-model-based-freshwater-aquatic-life-criteria-for-lead-following-us-environmental-protection-agency-guidelines
#1
David K DeForest, Robert C Santore, Adam C Ryan, Brian G Church, M Jasim Chowdhury, Kevin V Brix
The US Environmental Protection Agency's (USEPA's) current ambient water quality criteria (AWQC) for lead (Pb) in freshwater were developed in 1984. The criteria are adjusted for hardness, but more recent studies have demonstrated that other parameters, especially dissolved organic carbon (DOC) and pH, have a much stronger influence on Pb bioavailability. These recent studies have been used to support development of a biotic ligand model (BLM) for Pb in freshwater, such that acute and chronic Pb toxicity can be predicted over a wide range of water chemistry conditions...
June 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28636155/the-use-of-transnasal-humidified-rapid-insufflation-ventilatory-exchange-thrive-in-17-cases-of-subglottic-stenosis
#2
Kim To, Fleur Harding, McNeill Scott, Pamela Milligan, Iain J Nixon, Richard Adamson, Alistair F McNarry
Shared airway management in patients with subglottic stenosis (SGS) is challenging for both the anaesthetist and surgeon. Various methods of airway management have been described but currently no gold standard exists. Jet ventilation has been described as the preferred technique despite a UK National Survey highlighting potential complications including pneumothorax, pneumomediastinum, surgical emphysema, hypoxia and death. This article is protected by copyright. All rights reserved.
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28635975/our-responsibility-to-our-research-participants
#3
Anne Katz
As the readers of this journal know all too well, conducting a study takes a lot of time, energy, commitment, and, most of all, work. I do not have to list the myriad steps that need to be taken, often with delays in between, to take a study from good idea to analysis. There are often sweat and tears, if not blood, and, at the end of the process, there may be exhaustion. Then the piles of paper and data-rich files languish on a desk or computer, never to see the light of day. Or, perhaps, a manuscript is written and submitted and then rejected or needs extensive revision...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28635577/-an-intraoral-swelling-located-in-the-buccal-mucosa
#4
J Schortinghuis, M Contini
A 69-year-old woman presented with a bony hard swelling inside her left cheek. After clinical and radiographic examination, the diagnosis sialolithiasis of the main duct of the parotid gland was made. Surgical removal relieved her complaints.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28634764/are-wrongful-life-actions-threatening-the-value-of-human-life
#5
Vera Lúcia Raposo
Most courts around the world have been refusing wrongful life actions. The main argument invoked is that the supposed compensable injury cannot be classified as such, since life is always a blessing no matter how hard and painful it is.In opposition to mainstream scholars and the dominant case law, this article sustains that life must be distinguished from living conditions, the former being the real injury at stake, since some living conditions are so intolerable that in themselves they justify a compensation within wrongful life actions...
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28634458/phone-conversation-while-processing-information-chronometric-analysis-of-load-effects-in-everyday-media-multitasking
#6
Michael B Steinborn, Lynn Huestegge
This is a pilot study that examined the effect of cell-phone conversation on cognition using a continuous multitasking paradigm. Current theorizing argues that phone conversation affects behavior (e.g., driving) by interfering at a level of cognitive processes (not peripheral activity) and by implying an attentional-failure account. Within the framework of an intermittent spare-utilized capacity threading model, we examined the effect of aspects of (secondary-task) phone conversation on (primary-task) continuous arithmetic performance, asking whether phone use makes components of automatic and controlled information-processing (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28634407/analysis-of-survival-and-hatching-transcriptomes-from-potato-cyst-nematodes-globodera-rostochiensis-and-g-pallida
#7
Marc-Olivier Duceppe, Joël Lafond-Lapalme, Juan Emilio Palomares-Rius, Michaël Sabeh, Vivian Blok, Peter Moffett, Benjamin Mimee
Potato cyst nematodes (PCNs), Globodera rostochiensis and G. pallida, cause important economic losses. They are hard to manage because of their ability to remain dormant in soil for many years. Although general knowledge about these plant parasitic nematodes has considerably increased over the past decades, very little is known about molecular events involved in cyst dormancy and hatching, two key steps of their development. Here, we have studied the progression of PCN transcriptomes from dry cysts to hatched juveniles using RNA-Seq...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634141/one-step-preparation-of-spherical-drug-particles-by-contamination-free-dry-milling-technique-with-corn-starch-beads
#8
Toshiyuki Niwa, Maria Yoshida, Naoko Hayashi, Keita Kondo
The novel dry milling technique has been developed by using a mechanical powder processor for improving the dissolution properties of poorly water-soluble drugs. It was found that the drug crystals were well pulverized by co-processing with fine particles of corn starch (CS). The morphological observation and particle size evaluation revealed that the processed products formed the composite particles with ordered-mixed structure, having double-layered particles with a core of CS and a coating layer of phenytoin (Phe), as a model drug...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28633905/short-and-long-term-mortality-of-patients-presenting-with-bleeding-events-to-the-emergency-department
#9
Alberto Conti, Noemi Renzi, Daniele Molesti, Simone Bianchi, Irene Bogazzi, Giada Bongini, Giuseppe Pepe, Fabiana Frosini, Alessio Bertini, Massimo Santini
BACKGROUND: Death of patients presenting with bleeding events to the Emergency Department still represent a major problem. We sought to analyze clinical characteristics associated with worse outcomes including short- and long-term death, beyond antithombotic treatment strategy. METHODS: Patients presenting with any bleeding events during 2016-2017years were enrolled. Clinical parameters, site of bleeding, major bleeding, ongoing anti-thrombotic treatment strategy and death were collected...
June 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28633831/the-effects-of-organoclay-on-the-morphology-and-mechanical-properties-of-pai-clay-nanocomposites-coatings-prepared-by-the-ultrasonication-assisted-process
#10
Hamed Naderi-Samani, Reza Shoja Razavi, Mohammad Reza Loghman-Estarki, Mazaher Ramazani
In this research, solvent based polyamide - imide (PAI)/clay nanocomposites were prepared successfully using the solution dispersion technique. With the assistance of the ultrasonic wave, the effect of the ultrasonic wave time on the microstructure of 3wt% PAI/C20A nanocomposite (NC) was investigated. Then, the best ultrasonic parameters were selected and the effects of the concentration of Cloisite 20A (C20A) (1, 3 and 5wt% C20A) on the microstructure and mechanical properties (adhesion, hardness, flexibility, wear and impact) of NCs were investigated...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633756/immunotherapy-the-wave-of-the-future-in-bladder-cancer
#11
Daniel P Petrylak
Urothelial cell carcinoma (UC) is one of the most common cancers and one of the most deadly. Metastatic UC is particularly hard to treat, because it is typically diagnosed when patients are elderly and have medical comorbidities. Many patients with metastatic UC are unable to receive cisplatin-based chemotherapy, due to older age at diagnosis and comorbidities, and even when platinum chemotherapy can be administered, it has limited success in prolonging survival. Recently, improved understanding of molecular targets and immunologic characteristics of urothelial tumor cells has resulted in new therapeutic approaches that may help optimize first- and second-line therapy...
June 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28633725/well-differentiated-neuroendocrine-tumor-a-low-b-grade-tumor-s-aggressive-course-and-dismal-outcome-a-case-report
#12
Dinesh Atwal, Krishna Prasad Joshi, Susanne Jeffus, James Ntambi, Fade Mahmoud
INTRODUCTION: Incidence of well-differentiated neuroendocrine tumors (NETs) of the colon and rectum is increasing and is now approximately 1 per 100,000 in the US. NETs are either well-differentiated (indolent) or poorly differentiated (aggressive). The majority of these tumors are found incidentally during screening colonoscopies and rarely are associated with symptoms of hormonal syndrome, even during the advanced stage. Metastatic well-differentiated NETs of the colon and rectum are incurable, hard to treat, and associated with a poor prognosis and survival rates similar to colorectal adenocarcinoma survival...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28633391/kmerpyramid-an-interactive-visualization-tool-for-nucleobase-and-k-mer-frequencies
#13
Jochen Kruppa, Erhard van der Vries, Wendy K Jo, Alexander Postel, Paul Becher, Albert Osterhaus, Klaus Jung
Summary: Bioinformatics methods often incorporate the frequency distribution of nulecobases or k -mers in DNA or RNA sequences, for example as part of metagenomic or phylogenetic analysis. Because the frequency matrix with sequences in the rows and nucleobases in the columns is multi-dimensional it is hard to visualize. We present the R-package 'kmerPyramid' that allows to display each sequence, based on its nucleobase or k -mer distribution projected to the space of principal components, as a point within a 3-dimensional, interactive pyramid...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28633372/farmer-suicides-a-qualitative-study-from-australia
#14
M Perceval, K Kõlves, P Reddy, D De Leo
Background: Farmers in Australia, in general, have poorer health outcomes, including higher rates of suicide. Aims: To investigate risk and protective factors and attitudes towards suicide and help-seeking among farmers living and working in New South Wales and Queensland in Australia. Methods: A qualitative study in which three farming sites were selected in each state to represent an area with a suicide rate equal to, below and above the state average...
June 14, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28633359/does-long-term-intraoral-service-affect-the-mechanical-properties-and-elemental-composition-of-multistranded-wires-of-lingual-fixed-retainers
#15
Spiros Zinelis, Nikolaos Pandis, Youssef S Al Jabbari, George Eliades, Theodore Eliades
Purpose: The aim of this study was to evaluate the elemental and mechanical alterations of stainless steel (SS) multistranded orthodontic wires used in fixed retention after intraoral ageing. Materials and Methods: Two types of 0.022-inch, seven-stranded wires, Lingual Retainer Wire (LRW) and Tru-Chrome (TCH), from the same manufacturer (Rocky Mountain Orthodontics, Denver, Colo, USA) were tested. Thirty-three samples from LRW group and thirty-seven from TCH were collected, whereas three unused wires from each package were used as controls...
June 15, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28633341/swallowing-computed-tomography-dose-estimation-in-a-phantom-study-conducted-at-various-patient-reclining-angles
#16
Masanao Kobayashi, Yasuki Asada, Kosuke Matsubara, Kazuyuki Minami, Shouichi Suzuki, Yuta Matsunaga, Tomonobu Haba, Ai Kawaguchi, Tomihiko Daioku, Hiroshi Toyama, Ryoichi Kato
Swallowing computed tomography (SCT) is a relatively new technique for the morphological and kinematic analyses of swallowing. However, no optimal scan protocols are available till date. We conducted the present SCT study to estimate the patient dose at various patient reclining positions. A RANDO phantom with a thermoluminescent dosemeter was placed on a hard Table board in a semi-reclining position at the centre and off-centre. According to predetermined scan protocols, irradiation was performed to acquire scanograms at reclining angles of 55° and 65°...
June 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28632903/immunohistochemical-dissection-of-cystic-panfolliculoma-focusing-on-the-expression-of-multiple-hair-follicle-lineage-markers-with-an-insight-into-the-pathogenesis
#17
Masahiro Fukuyama, Yohei Sato, Yoshimi Yamazaki, Manabu Ohyama
Panfolliculoma (PF) is a rare benign tumor with signs of differentiation toward all components of the hair follicle (HF). Cystic panfolliculoma (CPF) is a subset of PF with histological similarity to trichofolliculoma making the differential diagnosis difficult in some cases. Immunohistopathological investigations of PF have been reported; however, previous studies focused mostly on the expression profile of the outer root sheath markers. A panel of antibodies was developed and used for the detection of the expression of cytokeratin (CK) 10, CK13, CK14, CK15, hair-hard keratin (AE13), and EpCAM within the lesion, supporting the differentiation of all epithelial lineages of the HF and the diagnosis of CPF...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632743/in-silico-assessment-of-the-effects-of-quinidine-disopyramide-and-e-4031-on-short-qt-syndrome-variant-1-in-the-human-ventricles
#18
Cunjin Luo, Kuanquan Wang, Henggui Zhang
AIMS: Short QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr) of SQTS, results from an inactivation-attenuated, gain-of-function mutation (N588K) in the KCNH2-encoded potassium channels. Pro-arrhythmogenic effects of SQT1 have been well characterized, but less is known about the possible pharmacological antiarrhythmic treatment of SQT1...
2017: PloS One
https://www.readbyqxmd.com/read/28632429/on-stable-states-in-a-topologically-driven-protein-folding-model
#19
Zheng Dai, David Becerra, Jérôme Waldispühl
Theoretical models of protein folding often make simplifying assumptions that allow analysis, yielding interesting theoretical results. In this article, we study models where folding dynamics is primarily driven by local topological features in an iterative manner. We illustrate the merit of the proposed approach through its ability to simulate realistic protein folding processes even when the sequence content information is reduced to just hydrophobic and polar. We then analyze our models and show that under our simple assumptions, certain structures are inherently unstable, and that determining whether structures can be stable is an [Formula: see text]-hard problem...
June 20, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28632397/decomposition-algorithms-for-a-multi-hard-problem
#20
M R Przybylek, A Wierzbicki, Z Michalewicz
Real-world optimization problems have been studied in the past, but the work resulted in approaches tailored to individual problems that could not be easily generalized. The reason for this limitation was the lack of appropriate models for the systematic study of salient aspects of real-world problems. The aim of this paper is to study one of such aspects: multi-hardness. We propose a variety of decomposition-based algorithms for an abstract multi-hard problem and compare them against the most promising heuristics...
June 20, 2017: Evolutionary Computation
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