keyword
https://read.qxmd.com/read/38530761/probiotics-supplementation-in-the-treatment-of-male-infertility-a-systematic-review
#1
REVIEW
Licia Cristina Silva de Lima Oliveira, Elton Carvalho Costa, Fernanda Domingues Gomes Martins, Alcenir Sales da Rocha, Girlandia Alexandre Brasil
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents...
March 26, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38525521/beneficial-effects-of-oral-antioxidant-supplementation-on-semen-quality-parameters-reproductive-hormones-and-sperm-dna-integrity-in-men-with-idiopathic-oligoasthenoteratozoospermia
#2
JOURNAL ARTICLE
Chaymae Rochdi, Meriem Ouadrhiri, Larbi Allai, Ibtissam Bellajdel, Samira Mamri, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri
OBJECTIVE: Recently, oral antioxidants in combined forms have been used to treat men with idiopathic infertility. This study aimed to evaluate the effects of treatment with vitamin C, vitamin E, selenium, zinc, arginine, L-carnitine, and coenzyme Q10 on sperm quality parameters, DNA integrity, reproductive hormones, and pregnancy rates in men with infertility and idiopathic oligoasthenoteratozoospermia (OAT). METHODS: A prospective study was conducted on 420 men with infertility and idiopathic OAT who took an oral supplement of antioxidant SP-Power tablets twice daily for 6 months...
March 25, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38525519/outcomes-of-female-reproductive-performance-with-assisted-reproductive-techniques-after-recent-mild-to-moderate-covid-19-infections-an-observational-study
#3
JOURNAL ARTICLE
Ashraf Moini, Narges Najafpour, Ladan Kashani, Maryam Farid-Mojtahedi, Arezoo Maleki-Hajiagha, Afsaneh Tehranian, Rana Karimi
OBJECTIVE: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients. METHODS: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF)...
March 25, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38524220/involvement-of-catsper-2-mutation-in-a-familial-context-of-unexplained-infertility-and-fertilization-failure-associated-with-hearing-loss-a-case-report
#4
JOURNAL ARTICLE
Simon Guignard, Christina Guillaume, Laurie Tornero, Jessika Moreau, Manon Carles, François Isus, Éric Huyghe, Célia Ravel, Nathalie Vergnolle, Céline Deraison, Chrystelle Bonnart, Nicolas Gatimel
OBJECTIVE: To explore the functional implications of a homozygous CATSPER 2 (cation channel for sperm) deletion within the acrosome reaction pathway during fertilization in 2 brothers, who have unexplained infertility and hearing loss. DESIGN: Case report. PATIENTS: Two twin brothers aged 30 years with hearing loss and unexplained infertility. EXPOSURE OR INTERVENTION: Molecular genetic diagnosis of deafness. Evaluation of the acrosome reaction and calcium mobilization assays after induction by progesterone and ionomycin on spermatozoa of the CATSPER 2 -mutated patient and on fertile controls...
March 2024: F&S reports
https://read.qxmd.com/read/38524219/prevalence-and-clinical-implications-of-biochemical-hypogonadism-in-patients-with-nonobstructive-azoospermia-undergoing-infertility-evaluation
#5
JOURNAL ARTICLE
Arnold P P Achermann, Sandro C Esteves
OBJECTIVE: To investigate the prevalence and clinical implications of biochemical hypogonadism in infertile men with nonobstructive azoospermia (NOA). DESIGN: Cohort study. SETTING: University-affiliated tertiary center for male reproductive health. PATIENTS: 767 consecutive normogonadotropic or hypergonadotropic patients with NOA undergoing infertility evaluation from 2014 to 2021. INTERVENTION: Patients aged 23-55 years underwent comprehensive clinical, hormonal, genetic, semen analysis, and histopathology evaluations and were classified on the basis of predefined baseline follicle-stimulating hormone (12 IU/L) and total testosterone (350 ng/dL) serum levels cutpoints into four groups: hypergonadotropic hypogonadal, hypergonadotropic eugonadal, normogonadotropic hypogonadal, and normogonadotropic eugonadal...
March 2024: F&S reports
https://read.qxmd.com/read/38524049/assessment-of-reproductive-health-knowledge-among-college-students-in-northwestern-india-a-cross-sectional-study
#6
JOURNAL ARTICLE
Shilpa Dutta, Akash More, Sanket Mahajan, Neha Nawale, Namrata Choudhary, Deepti Shrivastava
Background Reproductive health knowledge is a critical aspect of overall well-being, particularly among college students who represent a demographic transitioning into adulthood. In northwestern India, where cultural nuances and societal perceptions play a significant role, understanding the factors influencing reproductive health knowledge becomes imperative. This cross-sectional study explores the interplay between demographic factors and awareness of reproductive health and infertility treatment among college students in northwestern India...
February 2024: Curēus
https://read.qxmd.com/read/38522503/low-serum-anti-mullerian-hormone-is-linked-with-poor-semen-quality-in-infertile-men-screened-for-participation-in-an-rct
#7
JOURNAL ARTICLE
Rune Holt, Sam Kafai Yahyavi, Gustav Wall-Gremstrup, Mads Joon Jorsal, Frederikke Bay Toft, Niels Jørgensen, Anders Juul, Martin Blomberg Jensen
OBJECTIVE: Studies investigating associations between serum anti-Müllerian Hormone (AMH) and semen quality in infertile men have shown conflicting results. Here, we investigated possible associations between serum AMH and semen quality in infertile men. DESIGN: Infertile men were included during screening for participation in FITMI, a double-blinded, placebo-controlled 1:1, single-center randomized clinical trial. SUBJECTS: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH...
March 22, 2024: Fertility and Sterility
https://read.qxmd.com/read/38516277/-tex46-knockout-male-mice-are-sterile-secondary-to-sperm-head-malformations-and-failure-to-penetrate-through-the-zona-pellucida
#8
JOURNAL ARTICLE
Yoshitaka Fujihara, Haruhiko Miyata, Ferheen Abbasi, Tamara Larasati, Kaori Nozawa, Zhifeng Yu, Masahito Ikawa, Martin M Matzuk
Each year, infertility affects 15% of couples worldwide, with 50% of cases attributed to men. It is assumed that sperm head shape is important for sperm-zona pellucida (ZP) penetration but research has yet to elucidate why. We generated testis expressed 46 ( Tex46 ) knockout mice to investigate the essential roles of TEX46 in mammalian reproduction. We used RT-PCR to demonstrate that Tex46 was expressed exclusively in the male reproductive tract in mice and humans. We created Tex46 -/- mice using the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system and analyzed their fertility...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38499229/association-between-polycyclic-aromatic-hydrocarbons-and-infertility-in-u-s-women-national-health-and-nutrition-examination-survey-2013-2016
#9
JOURNAL ARTICLE
Xiaomei Wu, Suixiang Wang, Xiaoxiao Lin, Huanzhu Liang, Yingying Wu, Yuxuan Tan, Huixian Zeng, Qian Chen, Jie Wang, Feng Huang, Ziang Guo, Puyi Xing, Jiyu Nie, Huojie Yao, Yingyin Fu, Zhiyu Yang, Zurui Zeng, Hongbiao Xu, Xingming Zhong, Chunxia Jing
Although there is a body of research indicating the potential impact of polycyclic aromatic hydrocarbons (PAHs) exposure on male infertility, the understanding of how PAH might affect female infertility is still limited. This study aimed to evaluate associations of PAHs, both individually and as a mixture, with female infertility using multiple logistic regression, Bayesian kernel machine regression (BKMR), and quantile g-computation (QGC) models based on data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016...
March 16, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38497245/a-systematic-review-of-interventions-to-improve-male-knowledge-of-fertility-and-fertility-related-risk-factors
#10
REVIEW
Srinithy Krishnan, Michael P Daly, Ruth Kipping, China Harrison
Male infertility is a global health concern. The effectiveness of interventions developed to improve males' knowledge of fertility regulation and fertility-related risk factors remains unclear. This systematic review aimed to synthesize and evaluate the evidence for these interventions. Four databases were searched from inception to June 2023. Eligible studies examined interventions to increase fertility knowledge among presumed fertile males aged ≥16 years of age. Conference abstracts, protocols and studies without sex-disaggregated results for males were excluded...
December 2024: Human Fertility: Journal of the British Fertility Society
https://read.qxmd.com/read/38492496/effects-of-radiofrequency-electromagnetic-field-rf-emf-exposure-on-male-fertility-a-systematic-review-of-experimental-studies-on-non-human-mammals-and-human-sperm-in-vitro
#11
JOURNAL ARTICLE
Eugenia Cordelli, Lucia Ardoino, Barbara Benassi, Claudia Consales, Patrizia Eleuteri, Carmela Marino, Maurizio Sciortino, Paola Villani, Martin H Brinkworth, Guangdi Chen, James P McNamee, Andrew W Wood, Lea Belackova, Jos Verbeek, Francesca Pacchierotti
BACKGROUND: The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Reproductive health outcomes have been identified among the priority topics to be addressed. OBJECTIVES: To evaluate the effect of RF-EMF exposure on male fertility of experimental mammals and on human sperm exposed in vitro...
February 19, 2024: Environment International
https://read.qxmd.com/read/38492416/a-novel-homozygous-nonsense-variant-of-ak7-is-associated-with-multiple-morphological-abnormalities-of-the-sperm-flagella
#12
JOURNAL ARTICLE
Tianli Chang, Hongying Tang, Xu Zhou, Jingliang He, Nenghui Liu, Yanping Li, Wenpei Xiang, Zhongyuan Yao
RESEARCH QUESTION: Is the novel homozygous nonsense variant of AK7 associated with multiple morphological abnormalities of the sperm flagella (MMAF), a specific type of oligoasthenoteratozoospermia leading to male infertility? DESIGN: Whole-exome sequencing and Sanger sequencing were performed to identify potential gene variants. Immunoblotting and immunofluorescence were applied to confirm the relationship between mutated genes and disease phenotypes. The concentration of reactive oxygen species and the rate of apoptosis were measured to evaluate the mitochondrial function of spermatozoa...
December 8, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38492154/identification-of-novel-homozygous-asthenoteratospermia-causing-armc2-mutations-associated-with-multiple-morphological-abnormalities-of-the-sperm-flagella
#13
JOURNAL ARTICLE
Siyi Zhao, Qiong Liu, Lilan Su, Lanlan Meng, Chen Tan, Chunjia Wei, Huan Zhang, Tao Luo, Qianjun Zhang, Yue-Qiu Tan, Chaofeng Tu, Houyang Chen, Xingcheng Gao
PURPOSE: To identify the genetic causes of multiple morphological abnormalities in sperm flagella (MMAF) and male infertility in patients from two unrelated Han Chinese families. METHODS: Whole-exome sequencing was conducted using blood samples from the two individuals with MMAF and male infertility. Hematoxylin and eosin staining and scanning electron microscopy were performed to evaluate sperm morphology. Ultrastructural and immunostaining analyses of the spermatozoa were performed...
March 16, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38489097/association-between-gut-microbiota-and-male-infertility-a-two-sample-mendelian-randomization-study
#14
JOURNAL ARTICLE
Runpei Deng, Yebao Huang, Zhaohui Tian, Qingqi Zeng
Previous research has confirmed the significant association between gut microbiota (GM) and male infertility (MI), but the causality between them remains unclear. This study aims to investigate the causal relationship between GM and MI using Mendelian randomization (MR) and provide supplementary information for the optimization of future randomized controlled trials (RCTs). Instrumental variables for 211 GM taxa were obtained from genome-wide association studies (GWAS), and inverse variance weighted (IVW) method was used as the main analysis method for two-sample MR analysis to assess the impact of GM on the risk of MI...
March 15, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38481882/a-case-study-based-on-the-effect-of-phytoestrogen-on-an-oligozoospermic-patient
#15
Ritesh Jadhav, Akash More, Namrata Choudhary, Jarul Shrivastava, Shilpa Dutta, Gauri Gajabe, Saurabh Mehakar
We presented a 30-year-old man suffering from severe oligozoospermia caused by substantial sperm maturation arrest around the spermatid stage. Additionally, he was suffering from a varicocele. For three years, the couple had been trying to conceive. The clinical and endocrinological evaluation of the woman revealed that she was medically fit to undergo pregnancy. We performed laparoscopic ligation of the spermatic vein to treat the varicocele. Semen analysis was conducted at the beginning of the clinical pregnancy journey and after three and six months of treatment, which included 80 mg/day of phytoestrogens for six months...
February 2024: Curēus
https://read.qxmd.com/read/38481866/isolated-teratozoospermia-revisiting-its-relevance-in-male-infertility-a-narrative-review
#16
REVIEW
Widi Atmoko, Missy Savira, Rupin Shah, Eric Chung, Ashok Agarwal
BACKGROUND AND OBJECTIVE: Basic semen analysis is the first step in the evaluation of male infertility. It includes an assessment of sperm morphology which is believed to reflect on overall spermatogenesis and sperm function. Teratozoospermia, defined as abnormal sperm morphology, is frequently present in association with severe oligoasthenozoospermia, but isolated teratozoospermia (in the presence of normal counts and motility) is a poorly understood clinical entity with conflicting implications in terms of fertility potential and treatment strategies...
February 29, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38481407/sixth-edition-of-the-world-health-organization-laboratory-manual-of-semen-analysis-updates-and-essential-take-away-for-busy-clinicians
#17
JOURNAL ARTICLE
Eric Chung, Widi Atmoko, Ramadan Saleh, Rupin Shah, Ashok Agarwal
BACKGROUND: Semen analysis is the cornerstone for male fertility evaluation. In 2021, the World Health Organization (WHO) released its 6th edition of semen analysis manual. METHODS: We highlight the main changes in the latest 6th edition of the WHO manual of semen analysis and their possible interpretations. RESULTS: The manual is highly comprehensive, offering detailed information, and is widely regarded as an excellent technical reference for laboratory staff...
2024: Arab Journal of Urology
https://read.qxmd.com/read/38479056/associations-between-cytokines-and-the-risk-of-female-and-male-infertility-a-two-sample-mendelian-randomization-analysis
#18
JOURNAL ARTICLE
Lei Zhang, Honglin Li, Zhijuan Wu, Letian Han, Jianwei Zhang
PURPOSE: Observational studies have linked cytokines to the occurrence of female and male infertility. However, it is not clear how biomarkers of inflammation are causally related to infertility. To explore whether genetic variants in circulating cytokines are associated with the pathogenesis of infertility, we performed two-sample Mendelian randomization (MR) analysis. METHODS: A total of 31,112 individuals of European ancestry were included in a genome-wide association study (GWAS) of 47 circulating cytokines as instrumental variables (IVs)...
March 8, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38476958/micromapping-testicular-sperm-extraction-a-new-technique-for-microscopic-testicular-sperm-extraction-in-nonobstructive-azoospermia
#19
JOURNAL ARTICLE
Toshihiro Tai, Wakaba Miyamoto, Yuriko Fukuoka, Sena Shibasaki, Mizuho Takahashi, Noriyuki Okuyama, Hiromitsu Hattori, Ikue Ishikawa, Satoko Nagaura, Koki Yoshinaga, Masae Koizumi, Tomoko Hashimoto, Mayumi Toya, Jin Kumagai, Hideki Igarashi, Koichi Kyono
PURPOSE: In microscopic testicular sperm extraction (mTESE) for nonobstructive azoospermia (NOA), sperm can be recovered relatively easily in some cases, and mTESE may be retrospectively considered excessive. However, mTESE is routinely performed in the majority of NOA patients because of the difficulty in predicting tissue status. A minimally invasive and comprehensive sperm retrieval method that allows on-the-spot tissue assessment is needed. We have developed and evaluated a novel sperm retrieval technique for NOA called micromapping testicular sperm extraction (MMTSE)...
2024: Reproductive Medicine and Biology
https://read.qxmd.com/read/38470159/downregulation-of-mir-211-expression-in-the-blood-plasma-of-infertile-men-compared-to-the-fertile-controls
#20
JOURNAL ARTICLE
Nasim Naeimi, Homa MohseniKouchesfehani, Hamidreza Mahmoudzadeh-Sagheb, Saeed Movahed, Bita Moudi, Azam Asemirad, Nadia Sheibak, Zahra Heidari
OBJECTIVES: Infertility is inability to conceive after 12 months of regular unprotected sex. MiRNA expression changes can serve as potential biomarkers for infertility in males due to impaired spermatogenesis. This research was conducted to measure the expression level of miR-211 in plasma samples as a factor identifying infertility in comparison with the control group. METHODS: In this study, blood plasma were taken from the infertile men (n = 103) nonobstructive azoospermia (NOA) or severe oligozoospermia (SO) and the control group (n = 121)...
March 12, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
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