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Evaluation of male infertility

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https://www.readbyqxmd.com/read/28436704/association-of-cat-262c-t-with-the-concentration-of-catalase-in-seminal-plasma-and-the-risk-for-male-infertility-in-algeria
#1
Nour El Houda Bousnane, Sadiq May, Mouloud Yahia, Abed Alkarem Abu Alhaija
Catalase (CAT) plays a central role in the protection of different cell types against the deleterious effects of hydrogen peroxide. In human, CAT is implicated in many physiological and pathological conditions including idiopathic male infertility. In this study we examined the association between CAT levels in seminal plasma with different sperm parameters and with CAT-262 C/T polymorphism and their risk for idiopathic male infertility in Algeria. Semen and blood samples were obtained from 111 infertile males and 104 fertile controls from the region of Eastern Algeria following informed consent...
April 24, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28429340/controlled-prospective-observational-study-on-the-efficiency-and-tolerability-of-a-combination-of-potential-nrf2-inducing-antioxidants-and-micronutrients-as-pre-treatment-for-icsi-in-dyspermic-patients-with-previous-failure
#2
R Rago, M Gallo, A Dal Lago, E Licata, G Paciotti, M Amodei, C Meneghini, C Fabiani, G Dani, C Liberanome, D Antonaci, R Corno, D Miriello, G Giuffrida, B Giammusso
OBJECTIVE: To evaluate the efficiency of pre-treatment in dyspermic males in IVF couples with a combination of micronutrients, for the purpose of improving the fertilization rate, the implantation rate and the outcome of the pregnancy. PATIENTS AND METHODS: This controlled prospective clinical study was performed in two medically assisted reproduction centers. 59 males with mild oligo-astheno-teratospermia (OAT) were admitted to the study. All of them had a history of previous in vitro fertilization (IVF) attempts with female partners aged < 40 diagnosed having tubal or idiopathic infertility...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28421111/xrcc5-vntr-xrcc6-61c-g-and-xrcc7-6721g-t-gene-polymorphisms-associated-with-male-infertility-risk-evidences-from-case-control-and-in-silico-studies
#3
Danial Jahantigh, Abasalt Hosseinzadeh Colagar
We evaluate the association between genetic polymorphisms of XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T with male infertility susceptibility. A total of 392 men including 178 infertile males (102 idiopathic azoospermia and 76 severe oligozoospermia) and 214 healthy controls were recruited. XRCC6 -61C>G and XRCC7 6721G>T genotyping was performed by PCR-RFLP whereas XRCC5 VNTR was performed by PCR. The 2R allele and 2R allele carriers of XRCC5 VNTR polymorphism significantly decreased risk of male infertility...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28410062/role-of-imaging-in-the-evaluation-of-male-infertility
#4
Pardeep K Mittal, Brent Little, Peter A Harri, Frank H Miller, Lauren F Alexander, Bobby Kalb, Juan C Camacho, Viraj Master, Matthew Hartman, Courtney C Moreno
Infertility is defined herein as the inability to achieve pregnancy after frequently engaging in unprotected sexual intercourse for 1 year. Among infertile couples, the cause of infertility involves the male partner in approximately 50% of cases. Male infertility is usually caused by conditions affecting sperm production, sperm function, or both, or blockages that prevent the delivery of sperm. Chronic health problems, injuries, lifestyle choices, anatomic problems, hormonal imbalances, and genetic defects can have a role in male infertility...
April 14, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28409904/prevalence-of-varicocoele-and-its-association-with-body-mass-index-among-39-559-rural-men-in-eastern-china-a-population-based-cross-sectional-study
#5
J Liu, S Zhang, M Liu, Q Wang, H Shen, Y Zhang, D Yan
Varicocoele is a common cause of male infertility. We undertook a population-based cross-sectional study to evaluate the prevalence of varicocoele among rural men in eastern China and its association with body mass index. A total of 39,559 rural men in six counties in Beijing, Guangdong and Shandong provinces were recruited from 2011 to 2012. The presence and severity of varicocoele were measured by physical examinations. Univariate and multivariate logistic regression models were constructed to assess the association between varicocoele and body mass index after adjusting for possible confounders...
May 2017: Andrology
https://www.readbyqxmd.com/read/28407330/diffusion-weighted-and-magnetization-transfer-imaging-in-testicular-spermatogenic-function-evaluation-preliminary-results
#6
Huanjun Wang, Jian Guan, Jinhua Lin, Zhongwei Zhang, Shurong Li, Yan Guo, Huasong Cai
PURPOSE: To assess the use of functional magnetic resonance imaging (MRI), including diffusion-weighted MRI (DWI) and magnetization transfer MRI (MTI) in evaluating male infertility. MATERIALS AND METHODS: Sixteen men with testicular spermatogenesis hypofunction confirmed by percutaneous testis biopsy and 31 volunteers (control group B, age range: 20-40 years) with normal semen analysis including younger (By, n = 15, age range: 20-30 years) and older (Bo, n = 16, age range: 31-40 years) men underwent pelvic 3T MRI, including DWI and MTI...
April 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28403925/prevention-of-infertility-induced-by-ovarian-ischemia-reperfusion-injury-by-benidipine-in-rats-biochemical-gene-expression-histopathological-and-immunohistochemical-evaluation
#7
E Unlubilgin, B Suleyman, G Balci, R Atakan Al, M Cankaya, U Arslan Nayki, H Suleyman
INTRODUCTION: Benidipine has been reported to prevent the ischemia/reperfusion (I/R) damage in heart tissue and to suppress oxidant and proinflammatory cytokine production, increased by I/R. However, There was no information about the effects of benidipine on I/R injury in the ovary and the damage of I/R-induced infertility. OBJECTIVES: The aim of the study was to investigate the effects of benidipine on bilateral ovarian I/R injury and whether or not effective in the treatment of I/R-induced infertility in rats...
March 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28397035/association-between-mthfr-a1298c-polymorphism-and-male-infertility-a-meta-analysis
#8
Qiang Zhang, Guo-Ying Yin, Juan Liu, Yue Liang, Yao-Yan Li, Jing-Yu Zhao, Li-Wen Zhang, Bai-Qi Wang, Nai-Jun Tang
There have been several epidemiological studies evaluating the potential association between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and the risk of male infertility. However, the results obtained were inconsistent. Therefore, we performed a meta-analysis to further examine the association between the MTHFR A1298C polymorphism and male infertility. A comprehensive search was conducted to identify all eligible studies from the online literature databases published prior to January 15th, 2016...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28392800/cytotoxic-and-genotoxic-effects-of-acephate-on-human-sperm
#9
M A Thamali Dhanushka, L Dinithi C Peiris
Extensive use of organophosphorus pesticides (OPs) could alter semen quality and sperm DNA at different stages of spermatogenesis. Acephate is a highly toxic extensively used OP and, therefore, we aimed to evaluate the effects of acephate on human semen quality and sperm DNA integrity. Sperm collected from healthy males were exposed to 0, 50, 100, and 200 μg/mL of acephate and incubated for 1 h, 2 h, and 3 h. Subsequently, sperm motility, vitality, functional integrity of plasma membrane, sperm capacitation, and DNA damage were examined...
2017: Journal of Toxicology
https://www.readbyqxmd.com/read/28390187/prediction-of-male-fertility-using-capacitation-associated-proteins-in-spermatozoa
#10
REVIEW
Md Saidur Rahman, Woo-Sung Kwon, Myung-Geol Pang
Infertility and subfertility account for huge economic losses in the animal industry; indeed, 50% of animal breeding failure is associated with male infertility. Approximately 70% of cattle and 90% of pig livestock are currently produced by artificial insemination. Therefore, breeding-male selection is extremely important for the genetic benefits of progeny. Although conventional semen analysis provides an initial measure of male fertility, its clinical value is questionable. Proteomics approaches recently identified candidate protein markers in spermatozoa for evaluating male fertility...
April 8, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28381255/male-fertility-status-is-associated-with-dna-methylation-signatures-in-sperm-and-transcriptomic-profiles-of-bovine-preimplantation-embryos
#11
Jenna Kropp, José A Carrillo, Hadjer Namous, Alyssa Daniels, Sana M Salih, Jiuzhou Song, Hasan Khatib
BACKGROUND: Infertility in dairy cattle is a concern where reduced fertilization rates and high embryonic loss are contributing factors. Studies of the paternal contribution to reproductive performance are limited. However, recent discoveries have shown that, in addition to DNA, sperm delivers transcription factors and epigenetic components that are required for fertilization and proper embryonic development. Hence, characterization of the paternal contribution at the time of fertilization is warranted...
April 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28379541/resistance-to-apoptosis-and-autophagy-leads-to-enhanced-survival-in-sertoli-cells
#12
Ferial Aslani, Tim Sebastian, Miguel Keidel, Suada Fröhlich, Hans-Peter Elsässer, Hans-Christian Schuppe, Jörg Klug, Poornima Mahavadi, Monika Fijak, Martin Bergmann, Andreas Meinhardt, Sudhanshu Bhushan
STUDY QUESTION: What is the underlying mechanism of Sertoli cell (SC) resistance to cell death? SUMMARY ANSWER: High expression of pro-survival B cell lymphoma-2 (BCL2) proteins and inhibition of apoptosis and autophagy prolongs SC survival upon exposure to stress stimuli. WHAT IS KNOWN ALREADY: In human and in experimental models of orchitis, tolerogenic SC survive stress conditions, while germ cells undergo massive apoptosis. In general, non-dividing highly differentiated cells tend to resist stress conditions for a longer time by favoring activation of pro-survival mechanisms and inhibition of cell death pathways...
April 3, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28376421/congenital-absence-of-vas-deferens-and-ectopic-kidney
#13
Alobaidi Salwan, Alhmooze Abdelrahman
INTRODUCTION: Congenital absence of the vas deferens (CUAVD) is a rare clinical entity, usually discovered accidently during surgical procedures of the urogenital zone, CUAVD has the prevalence of 0.5-1.0% in male population and it is associated with various forms of congenital genitourinary malformations like renal agenesis. we present a case of a 21 years old, male, managed in our private hospital for varicoceles and discovered to have CUAVD and ectopic kidney. PRESENTATION OF CASE: A 21 years old male, with no significant medical or surgical history presented to our out-patient clinic complaining of scrotal heaviness and pain...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28361989/testis-transcriptome-modulation-in-klinefelter-patients-with-hypospermatogenesis
#14
Marco D'Aurora, Alberto Ferlin, Andrea Garolla, Sara Franchi, Laura D'Onofrio, Oriana Trubiani, Giandomenico Palka, Carlo Foresta, Liborio Stuppia, Valentina Gatta
The main genetic cause of male infertility is represented by the Klinefelter Syndrome (KS), a condition accounting for 3% of all cases of infertility and up to15% of cases of azoospermia. KS is generally characterized by azoospermia; approximately 10% of cases have severe oligozoospermia. Among these, the 30-40% of patients show hypospermatogenesis. The mechanisms leading to adult testis dysfunctions are not completely understood. A microarray transcriptome analysis was performed on testis biopsies obtained from three KS patients with hypospermatogenesis and three control subjects...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28334509/disturbed-testicular-expression-of-the-estrogen-metabolizing-enzymes-cyp1a1-and-comt-in-infertile-men-with-primary-spermatogenic-failure-possible-negative-implications-on-sertoli-cells
#15
A Parada-Bustamante, C Molina, C Valencia, M Flórez, M C Lardone, F Argandoña, A Piottante, M Ebensperguer, P A Orihuela, A Castro
Estradiol (E2 ) is normally metabolized to hydroxyestradiols and methoxyestradiols by CYP1A1, CYP1B1 and COMT. However, an altered production of these metabolites by a disturbed expression of these enzymes is associated with reproductive and non-reproductive pathologies. In vitro studies suggest that increased hydroxyestradiols and methoxyestradiols intratesticular generation is related to male infertility, but no studies have explored whether infertile men have a disturbed testicular expression of the enzymes that generate these E2 metabolites...
May 2017: Andrology
https://www.readbyqxmd.com/read/28334508/dietary-fatty-acids-influence-sperm-quality-and-function
#16
A Ferramosca, N Moscatelli, M Di Giacomo, V Zara
Recently, obesity has been linked to male infertility. In animal models the administration of a high-fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high-fat diet. Sexually mature male Sprague-Dawley rats were divided into four groups and fed for 4 weeks a standard diet (control group), a high-fat diet (enriched in 35% of fat and 15% sucrose), a high-fat diet supplemented with 2...
May 2017: Andrology
https://www.readbyqxmd.com/read/28333357/dietary-patterns-foods-and-nutrients-in-male-fertility-parameters-and-fecundability-a-systematic-review-of-observational-studies
#17
Albert Salas-Huetos, Mònica Bulló, Jordi Salas-Salvadó
BACKGROUND: Infertility is a global public health issue, affecting 15% of all couples of reproductive age. Male factors, including decreased semen quality, are responsible for ~25% of these cases. The dietary pattern, the components of the diet and nutrients have been studied as possible determinants of sperm function and/or fertility. OBJECTIVE AND RATIONALE: Previous systematic reviews have been made of the few heterogeneous low-quality randomized clinical trials (RCTs) conducted in small samples of participants and investigating the effect of specific nutrients and nutritional supplements on male infertility...
March 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28333338/drug-discovery-for-male-subfertility-using-high-throughput-screening-a-new-approach-to-an-unsolved-problem
#18
Sarah J Martins da Silva, Sean G Brown, Keith Sutton, Louise V King, Halil Ruso, David W Gray, Paul G Wyatt, Mark C Kelly, Christopher L R Barratt, Anthony G Hope
STUDY QUESTION: Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? SUMMARY ANSWER: High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor infertility. WHAT IS KNOWN ALREADY: There is both huge demand and a genuine clinical need for new treatment options for infertile men. However, the time, effort and resources required for drug discovery are currently exorbitant, due to the unique challenges of the cellular, physical and functional properties of human spermatozoa and a lack of appropriate assay platform...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333023/hyaluronan-binding-system-for-sperm-selection-enhances-pregnancy-rates-in-icsi-cycles-associated-with-male-factor-infertility
#19
Renata F Erberelli, Renato M Salgado, Dirceu H Mendes Pereira, Philip Wolff
OBJECTIVES: The aim of the present study was to compare two procedures for sperm selection in ICSI cycles - conventional morphology sperm selection (ICSI-PVP) and chemical selection through Hyaluronan-treated petri dishes (PICSI), when male factor was associated. METHODS: The evaluated parameters were semen quality, fertilization and cleavage rates, chemical and clinical pregnancy rates, as well as abortion rate. Fifty-six ICSI cycles were included in this report, 19 cycles using PICSI and 37 using conventional ICSI...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28330865/an-automated-smartphone-based-diagnostic-assay-for-point-of-care-semen-analysis
#20
Manoj Kumar Kanakasabapathy, Magesh Sadasivam, Anupriya Singh, Collin Preston, Prudhvi Thirumalaraju, Maanasa Venkataraman, Charles L Bormann, Mohamed Shehata Draz, John C Petrozza, Hadi Shafiee
Male infertility affects up to 12% of the world's male population and is linked to various environmental and medical conditions. Manual microscope-based testing and computer-assisted semen analysis (CASA) are the current standard methods to diagnose male infertility; however, these methods are labor-intensive, expensive, and laboratory-based. Cultural and socially dominated stigma against male infertility testing hinders a large number of men from getting tested for infertility, especially in resource-limited African countries...
March 22, 2017: Science Translational Medicine
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