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Methyl chloride

Chizoba I Ezugwu, Md Ali Asraf, Xiao Li, Shengwei Liu, Chih-Ming Kao, Serge Zhuiykov, Francis Verpoort
Industrial dye effluents with low biodegradability are highly toxic and carcinogenic on both human and aquatic lives, thus they are detrimental to the biodiversity of environment. Herein, this data set presents the potential of cationic Nickel based MOFs in the adsorption of charged and neutral dye molecules. Data set include a concise description of experimental conditions for the synthesis of imidazolium ligands, 1,3-bis(4-carboxyphenyl)imidazolium chloride (H2 L+ Cl- ) and 1,3-bis(3,5-dicarboxyphenyl)imidazolium chloride (H4 L+ Cl- ), and MOFs...
June 2018: Data in Brief
Muhammad Athar Abbasi, Mubashir Hassan, Aziz-Ur-Rehman, Sabahat Zahra Siddiqui, Hussain Raza, Syed Adnan Ali Shah, Sung-Yum Seo
The present article describes the synthesis, in vitro urease inhibition and in silico molecular docking studies of a novel series of bi-heterocyclic bi-amides. The synthesis of title compounds was initiated by benzoylation, with benzoyl chloride (1), of the key starter ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (2) in weak basic aqueous medium followed by hydrazide formation, 4, and cyclization with CS2 to reach the parent bi-heterocyclic nucleophile, N-{4-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1,3-thiazol-2-yl}benzamide (5)...
June 7, 2018: Bioorganic & Medicinal Chemistry
Dong-Jin Ye, Yeo-Jung Kwon, Hyoung-Seok Baek, Sangyun Shin, Choongho Lee, Jun-Won Yun, Ki-Taek Nam, Kyung-Min Lim, Young-Jin Chun
Numerous studies have attempted to develop a new in vitro eye irritation test (EIT). To obtain more reliable results from EIT, potential new biomarkers that reflect eye irritation by chemicals must be identified. We investigated candidate biomarkers for eye irritation, using a proteomics approach. Sodium lauryl sulfate (SLS) or benzalkonium chloride (BAC) was applied on a reconstructed human cornea-like epithelium model, MCTT HCETM, and corneal protein expression was examined by two-dimensional gel electrophoresis...
June 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Changwen Hong, Xuelin Sui, Ziqian Li, Wenmin Pang, Min Chen
The phosphine phosphonic amide ligand platform is highly versatile, with three positions that can be independently tuned. In this contribution, we wish to study the nickel complexes based on this ligand system. Interestingly, the nickel dibromide and nickel allyl complexes are not active in ethylene polymerization. In contrast, the nickel phenyl chloride complexes are highly active in ethylene polymerization in the presence of a sodium tetrakis(3,5-bis(trifluoromethyl)phenyl)borate cocatalyst. In addition, these nickel complexes can initiate ethylene copolymerizations with polar functionalized comonomers including methyl 10-undecenoate, 6-chloro-1-hexene and 5-acetoxy-1-pentene...
June 11, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Julia V Bukanova, Elena I Solntseva, Sergey N Kolbaev, Eva Kudova
The ability of pregnanolone glutamate (PA-Glu), pregnanolone hemisuccinate (PA-hSuc) and pregnanolone hemipimelate (PA-hPim), neuroactive steroids with a negative modulatory effect on excitatory N-methyl-d-aspartate receptors, to influence the functional activity of inhibitory γ-aminobutyric acid and glycine receptors was estimated. The GABA- and glycine-induced chloride currents (IGABA and IGly ) were measured in isolated pyramidal neurons of the rat hippocampus using the patch-clamp technique. Compound PA-Glu was found to potentiate IGABA and to inhibit IGly , while PA-hSuc and PA-hPim inhibited both IGABA and IGly ...
June 7, 2018: Neurochemistry International
Mark C Moffett, John H McDonough, Joseph D McMonagle, Todd M Myers
Oxime reactivators are critical antidotes after organophosphate pesticide or nerve agent poisoning, directly restoring the function of inhibited acetylcholinesterase. In the continuing search for more broad-spectrum acetylcholinesterase reactivators, this study evaluated one of the leading next-generation oxime reactivators: methoxime, (1,1'-trimethylene bis[4-(hydroxyimino)methyl]pyridinium dichloride (MMB-4). The pharmacokinetics of both salts of MMB-4 (dichloride [2Cl] and dimethanesulphonate [DMS]) were characterized across a range of relevant doses (19, 58, and 116 µmol/kg, intramuscular) in a nonhuman primate model (male African green monkeys), and only subtle differences were observed between the salts...
January 1, 2018: International Journal of Toxicology
Rajangam Jagadeesan, Gopal Sabapathi, Jaccob Madhavan, Ponnambalam Venuvanalingam
Bonding and reactivity of [(R N4)Pd n CH3 X]( n-2)+ complexes have been investigated at the M06/BS2//B3LYP/BS1 level. Feasible mechanisms for the unselective formation of ethane and methyl chloride from mono-methyl PdIII complexes and selective formation of ethane or methyl chloride from PdIV complexes are reported here. Density functional theory (DFT) results indicate that PdIV is more reactive than PdIII and Pd in different oxidation states that follow different mechanisms. PdIII complexes react in three steps: (i) conformational change, (ii) transmetalation, and (iii) reductive elimination...
June 6, 2018: Inorganic Chemistry
Favián Treulen, María Elena Arias, Luis Aguila, Pamela Uribe, Ricardo Felmer
When the mitochondria of somatic cells are exposed to pathological calcium overload, these trigger mitochondrial permeability transition (MPT) leading to mitochondrial dysfunction and cell death. Cryopreservation procedures expose mammalian spermatozoa to physical and chemical stressors, which affect plasma membrane integrity and induce a pathological calcium overload that gradually promotes loss of sperm quality and ultimately function. Although several studies highlight the role of calcium in many physiological and pathological processes, the MPT induced by an intracellular calcium increase and its effect on the cell quality of mammalian spermatozoa are unknown...
June 1, 2018: Cryobiology
Qian Li, Zhengli Yang, Peng Zhang, Yifan Zhao, Xinchun Yu, Peng Xue, Yiming Shao, Qiang Li, Xiaodong Jia, Qi Zhang, Longzhen Cheng, Miao He, Zhijun Zhou, Yubin Zhang
Although immunotoxic effects of mercury (Hg) have been extensively investigated, the influence of Hg on hematopoietic stem cells (HSC) remains elusive. The aim of this study was to investigate the effects of Hg on HSC. B10.S (H-2s ) and DBA/2 mice (H-2d ) were treated with Hg chloride (25, 50 or 100 μM HgCl2 ) or methyl Hg (1.25, 3.75 or 6.25 μM MeHg) via drinking water for 4 weeks, and thereafter, HSC in the bone marrow (BM) were evaluated. The number of HSC in B10.S mice was increased after treatment with 50 μM HgCl2 and decreased after treatment with 100 μM HgCl2 ; the number of HSC in DBA/2 mice was reduced after treatment with 50 μM HgCl2 and unaffected after treatment with 25 μM HgCl2 ...
May 31, 2018: Toxicology Letters
Britni Skillman, Sarah Kerrigan
Suvorexant is a novel drug for the treatment of insomnia that is marketed under the trade name Belsomra®. Unlike other hypnotics, suvorexant is a dual orexin receptor antagonist that is believed to have a lower abuse potential compared to other therapeutics. Although sedative hypnotics feature prominently in forensic toxicology investigations, there have been limited reports that describe the analysis of suvorexant in biological samples. Following a 10-mg oral dose, peak concentrations are typically <200 ng/mL...
May 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Stefano Canossa, Giovanni Predieri, Claudia Graiff
Two unprecedented solid phases involving the 3,7-bis-(di-methyl-amino)-pheno-thia-zin-5-ium cation, i.e. methyl-ene blue ( MB+ ), have been obtained and structurally characterized. In the crystals of 3,7-bis-(di-methyl-amino)-pheno-thia-zin-5-ium chloride dihydrate, C16 H18 N3 S+ ·Cl- ·2H2 O ( I ) and 3,7-bis-(di-methyl-amino)-pheno-thia-zinium bis-ulfite, C16 H18 N3 S+ ·HSO4 - ( II ), the cationic dye mol-ecules are planar and disposed in an anti-parallel mode, showing π-π stacking inter-actions, with mean inter-planar distances of 3...
May 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Issei Takeuchi, Rina Mikuni, Kimiko Makino
BACKGROUND/AIM: In the use of paclitaxel, side-effects caused by itself or solubilizing agents have become a major obstacle. In this study we aimed to synthesize biocompatible and degradable compounds for micelles to be used as carriers for paclitaxel. MATERIALS AND METHODS: Methoxypolyethylene glycol-lactate was obtained from methyl lactate and methoxypolyethylene glycol having a molecular weight of 350. Monoalkoxy phosphoryl chlorides were obtained from phosphoryl chloride and four kinds of linear alcohols...
June 2018: Anticancer Research
Hao Wang, Weisha Liu, Meng Sun, Dubo Chen, Lingbing Zeng, Liqun Lu, Jing Xie
BACKGROUND: Grass carp (Ctenopharyngodon idella) hemorrhagic disease is caused by an acute infection with grass carp reovirus (GCRV). The frequent outbreaks of this disease have suppressed development of the grass carp farming industry. GCRV104, the representative strain of genotype III grass carp (Ctenopharyngodon idella) reovirus, belongs to the Spinareovirinae subfamily and serves as a model for studying the strain of GCRV which encodes an outer-fiber protein. There is no commercially available vaccine for this genotype of GCRV...
May 24, 2018: Virology Journal
Suguna Perumal, Atchudan Raji, In Woo Cheong
Measurement of the interaction force between two materials provides important information on various properties, such as adsorption, binding or compatibility for coatings, adhesion, and composites. The interaction forces of zwitterionic and ionic monomers with graphite platelets (G) and reduced graphene oxide (rGO) surfaces were systematically investigated using atomic force microscopy (AFM) in air and water. The monomers examined were 2-(methacryloyloxy)ethyl 2-(trimethylammonio)ethyl phosphate (MPC), [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBE), [2-(acryloyloxy)ethyl]trimethylammonium chloride (ATC), and 2-methyl-2-propene-1-sulfonic acid sodium (MSS)...
May 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Gabriela Chango, Edwin Palacio, Víctor Cerdà
A simple potentiometric chip-based multipumping flow system (MPFS) has been developed for the simultaneous determination of fluoride, chloride, pH, and redox potential in water samples. The proposed system was developed by using a poly(methyl methacrylate) chip microfluidic-conductor using the advantages of flow techniques with potentiometric detection. For this purpose, an automatic system has been designed and built by optimizing the variables involved in the process, such as: pH, ionic strength, stirring and sample volume...
August 15, 2018: Talanta
Tony D Davis, Sylvia Kunakom, Michael D Burkart, Alessandra S Eustaquio
S-adenosyl-l-methionine (SAM) is universal in biology, serving as the second most common cofactor in a variety of enzymatic reactions. One of the main roles of SAM is the methylation of nucleic acids, proteins, and metabolites. Methylation often imparts regulatory control to DNA and proteins, and leads to an increase in the activity of specialized metabolites such as those developed as pharmaceuticals. There has been increased interest in using SAM analogs in methyltransferase-catalyzed modification of biomolecules...
2018: Methods in Enzymology
Afshin Asadzadeh Shahir, Khristo Khristov, Khoi Tan Nguyen, Anh V Nguyen, Elena D Mileva
Some salts have been recently shown to decrease the SFG (sum frequency generation spectroscopy) intensity of the hydrogen-bonded water molecules, but a quantitative explanation is still awaited. Here we report a similar trend for the chloride salts of monovalent cations, i.e., LiCl, NaCl, and CsCl, at low concentrations. Specifically, we revealed not only the specific adsorption of cations at the water surface but also the concentration-dependent effect of ions on the SFG response of the interfacial water molecules...
May 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Abdullah Alzahrani, Styliana I Mirallai, Benjamin A Chalmers, Patrick McArdle, Fawaz Aldabbagh
The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these monomeric precursors to stimuli-responsive polymers by the addition of acrylamides and methacrylamides onto in situ generated or freshly isolated methylene Schiff base (iminium) salts. The X-ray crystal structure of the hydrated iminium salt, 1-(hydroxymethyl)azocan-1-ium chloride and monomer·HCl salt (N-[(azocan-1-yl)methyl]prop-2-enamide hydrochloride) is described...
May 18, 2018: Organic & Biomolecular Chemistry
Upendra Kumar Singh, Rajan Patel
In vitro refolding of denatured proteins and influence of alkyl chain of these organic salts on their performance as refolding enhancers was tested using long chain imidazolium chloride salts, 1-methyl-3-octylimidazolium chloride [C8mim][Cl], 1-decyl-3-methylimidazolium chloride [C10mim][Cl]. The horse heart cytochrome c (h-cyt c) was denatured by urea and guanidinium hydrochloride (GdnHCl), as well as base induced denaturation at pH 13 to provide a broad overview of the overall refolding behavior. The variation in alkyl chain of ionic liquids (ILs) showed a profound effect on the refolding of denatured h-cyt c...
May 16, 2018: Molecular Pharmaceutics
Alshaimaa A Elgarf, David C B Siebert, Friederike Steudle, Angelika Draxler, Guanguan Li, Shengming Huang, James M Cook, Margot Ernst, Petra Scholze
Benzodiazepines are clinically relevant drugs, which bind to GABAA neurotransmitter receptors at the α+/γ2- interfaces and thereby enhance GABA induced chloride ion flux leading to neuronal hyperpolarization. However, the structural basis of benzodiazepine interactions with their high affinity site at GABAA receptors is controversially debated in the literature and in silico studies led to discrepant binding mode hypotheses. In the current study computational docking of diazepam into α+/γ2- homology models suggested that a chiral methyl group, which is known to promote preferred binding to α5-containing GABAA receptors (position 3 of the 7-membered diazepine ring), could possibly provide experimental evidence in favor of or against the so far proposed binding modes...
May 16, 2018: ACS Chemical Biology
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