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https://www.readbyqxmd.com/read/29129676/exercise-enhances-cognitive-function-and-neurotrophin-expression-in-the-hippocampus-accompanied-by-changes-in-epigenetic-programming-in-senescence-accelerated-mice
#1
Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
Aerobic exercise is known to increase expression of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), in the hippocampus and to improve cognitive function. Exercise exerts neuroprotective effects in the hippocampus by inducing epigenetic changes, which play crucial roles in aging and neurodegenerative diseases. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation and modulate gene transcription. The objective of the present study was to assess the interactive effects of exercise and aging on cognitive function, expression of neurotrophins (BDNF and neurotrophin-4) and their receptors (tyrosine receptor kinase B and p75), and epigenetic regulations, including the activity of HATs and HADCs in the hippocampus...
November 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29129022/heat-acclimation-decay-and-re-induction-a-systematic-review-and-meta-analysis
#2
REVIEW
Hein A M Daanen, Sebastien Racinais, Julien D Périard
BACKGROUND: Although the acquisition of heat acclimation (HA) is well-documented, less is known about HA decay (HAD) and heat re-acclimation (HRA). The available literature suggests 1 day of HA is lost following 2 days of HAD. Understanding this relationship has the potential to impact upon the manner in which athletes prepare for major competitions, as a HA regimen may be disruptive during final preparations (i.e., taper). OBJECTIVE: The aim of this systematic review and meta-analysis was to determine the rate of HAD and HRA in three of the main physiological adaptations occurring during HA: heart rate (HR), core temperature (T c), and sweat rate (SR)...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29124455/measuring-and-understanding-adherence-in-a-home-based-exercise-intervention-during-chemotherapy-for-early-breast-cancer
#3
K A Nyrop, A M Deal, S K Choi, C W Wagoner, J T Lee, A Wood, C Anders, L A Carey, E C Dees, T A Jolly, K E Reeder-Hayes, H B Muss
PURPOSE: Ensuring and measuring adherence to prescribed exercise regimens are fundamental challenges in intervention studies to promote exercise in adults with cancer. This study reports exercise adherence in women who were asked to walk 150 min/week throughout chemotherapy treatment for early breast cancer. Participants were asked to wear a Fitbit(TM) throughout their waking hours, and Fitbit steps were uploaded directly into study computers. METHODS: Descriptive statistics are reported, and both unadjusted and multivariable linear regression models were used to assess associations between participant characteristics, breast cancer diagnosis, treatment, chemotherapy toxicities, and patient-reported symptoms with average Fitbit steps/week...
November 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29124370/popular-weight-loss-strategies-a-review-of-four-weight-loss-techniques
#4
REVIEW
Jonathan Obert, Michelle Pearlman, Lois Obert, Sarah Chapin
PURPOSE OF REVIEW: The purpose of this paper is to review the epidemiology of obesity and the most recent literature on popular fad diets and exercise regimens that are used for weight loss. The weight loss plans that will be discussed in this article include juicing or detoxification diets, intermittent fasting, the paleo diet, and high intensity training. RECENT FINDINGS: Despite the growing popularity of fad diets and exercise plans for weight loss, there are limited studies that actually suggest these particular regimens are beneficial and lead to long-term weight loss...
November 9, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29115052/dose-selection-based-on-modeling-and-simulation-for-rivipansel-in-pediatric-patients-aged-6-to-11-years-with-sickle-cell-disease
#5
Brinda K Tammara, Lutz O Harnisch
This modeling and simulation exercise aimed to provide dosing recommendations for rivipansel phase 3 studies in children aged 6 to 11 years with sickle cell disease (SCD). Pharmacokinetic data from 109 patients aged 12 to 51 years who received rivipansel (2-40 mg/kg) in previous studies (3 phase 1, one phase 2) were integrated to build a 3-compartmental simulation model. Renal clearance simulations across the age range accounted for renal function development and postulated hyperfiltration in SCD. Simulated demographic distributions for the pediatric SCD population were used to predict concentration-time profiles from 3 dosing regimens, which were then compared against efficacious average steady-state concentrations observed in phase 2...
November 8, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29114534/immediate-effect-of-passive-static-stretching-versus-resistance-exercises-on-postprandial-blood-sugar-levels-in-type-2-diabetes-mellitus-a-randomized-clinical-trial
#6
Peeyoosha Gurudut, Abey P Rajan
The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. In India, more than 61.3 million people have been presently diagnosed with type 2 diabetes mellitus. It is possible to control the circulating blood glucose levels by reducing life style risk factors through physical activities comprising of muscle stretches, aerobic training, resistance exercises (REs), yoga, etc. The aim of this study is to identify and compare the immediate effect of passive static stretching (PSS) versus RE on blood glucose level in individuals with type 2 diabetes mellitus...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29113760/strengths-weaknesses-and-future-challenges-of-biosimilars-development-an-opinion-on-how-to-improve-the-knowledge-and-use-of-biosimilars-in-clinical-practice
#7
Cristina Scavone, Concetta Rafaniello, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy and safety profiles) features of new biosimilars with their respective reference products. Despite the undeniable advantages of such procedure, some concerns (such as the absence of switching studies or the evaluation of efficacy and safety in all therapeutic indications) still exist about its...
November 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29113570/a-novel-downhill-gait-training-program-following-a-total-knee-arthroplasty-a-case-report-highlighting-the-impacts-of-self-selected-speed-on-gait-symmetry
#8
Cody Blue, Sara Coomes, Yuri Yoshida
Study Design Case report. Background Walking plays an essential role in activities of daily living that lead to varied health benefits. Studies report gait speed and symmetry are impacted in individuals following TKA. Unfortunately, abnormal gait patterns persistently exist in individuals after TKA. Downhill walking may provide a simple and feasible exercise regimen to improve gait patterns. The purpose of this case report is to describe the application of a downhill treadmill training program and the subsequent changes in gait patterns in an individual following a unilateral TKA...
November 7, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29103210/insulin-for-the-treatment-of-women-with-gestational-diabetes
#9
REVIEW
Julie Brown, Luke Grzeskowiak, Kathryn Williamson, Michelle R Downie, Caroline A Crowther
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with short- and long-term complications for the mother and her infant. Women who are unable to maintain their blood glucose concentration within pre-specified treatment targets with diet and lifestyle interventions will require anti-diabetic pharmacological therapies. This review explores the safety and effectiveness of insulin compared with oral anti-diabetic pharmacological therapies, non-pharmacological interventions and insulin regimens...
November 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29103050/motivators-and-barriers-to-exercise-in-parkinson-s-disease
#10
Mitra Afshari, Amy Yang, Danny Bega
BACKGROUND: Despite evidence for the benefits of exercise in Parkinson's disease (PD), many patients remain sedentary for undefined reasons. OBJECTIVE: To compare exercise habits, perceptions about exercise, and barriers to exercise in 'low' (<3 h/week) and 'high' (≥3 h/week) exercisers with PD. METHODS: A 48-item survey was administered to PD patients at an outpatient academic center. Chi-squared tests were used to compare the percentage differences between low- and high-exercisers with two-sided tests and a significant level of 0...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29101174/dietary-nitrate-supplementation-in-cardiovascular-health-an-ergogenic-aid-or-exercise-therapeutic
#11
Mary N Woessner, Luke Colin McIlvenna, Joaquin Ortiz de Zevallos, Christopher Neil, Jason David Allen
Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to NO in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes, however, the ergogenic benefits are currently unclear due to a variety of factors including small sample sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants' initial fitness levels and the types of exercise tests employed...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29098613/exercise-exerts-its-beneficial-effects-on-acute-coronary-syndrome-clinical-evidence
#12
Zhuyuan Liu, Huanyu Gu, Qiying Dai, Hongbao Wang, Jianhua Yao, Lei Zhou
Acute coronary syndrome (ACS) is characterized with high morbidity, high mortality, long hospitalization and frequent revisits. It has been the most serious coronary artery diseases in the world. A large body of clinical evidence demonstrates that exercise is associated with reduced cardiovascular disease risk. In addition, different types of exercise have become the central to most cardiac rehabilitation/risk reduction programs. However, the detailed effects of exercise in ACS is still unclear and there is still lack of evidence on which exercise regimen may be ideal for ACS...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29098271/flow-and-grit-by-design-exploring-gamification-in-facilitating-adherence-to-swallowing-therapy
#13
Gabriela Constantinescu, Jana Rieger, Kerry Mummery, William Hodgetts
Purpose: Delivery of swallowing therapy is faced with challenges regarding access to in-clinic services and adherence to prescribed home programs. Mobile health (mHealth) technologies are being developed at a rapid pace to address these difficulties. Whereas some benefits to using these modern tools for therapy are obvious (e.g., electronic reminders), other advantages are not as well understood. One example is the potential for mHealth devices and apps to enhance adherence to treatment regimens...
November 8, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29083275/albiglutide-efficacy-and-safety-in-the-latino-hispanic-subpopulation-for-the-integrated-phase-iii-program
#14
Jaime A Davidson, Angela Jones-Leone, Timothy H Wilson, Antonio Nino, Sergio Forero-Schwanhaeuser, Rickey R Reinhardt
OBJECTIVE: to evaluate the efficacy and safety of albiglutide compared with placebo and active comparators from an integrated trial subpopulation of Latino/Hispanic patients whose type 2 diabetes mellitus (T2DM) was inadequately controlled on their current regimen of diet and exercise, with or without oral antidiabetic drugs (OADs) and/or insulin. METHODS: Latino/Hispanic patient subpopulations (N = 1204) across 7 phase III albiglutide studies (N = 4400) were evaluated post-hoc for efficacy and safety...
October 30, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29068433/diet-and-exercise-interventions-for-pediatric-cancer-patients-during-therapy-tipping-the-scales-for-better-outcomes
#15
REVIEW
Keri L Schadler, Eugenie S Kleinerman, Joya Chandra
Obesity at diagnosis is a negative prognostic indicator for several pediatric cancers including acute leukemia and bone tumors. Incidence of obesity in children has increased three-fold over the past 2 decades, and causes for this include poor diet, excessive caloric intake, and lack of physical activity, which are collectively referred to as energy balance-related behaviors. Few energy balance interventions have been implemented in pediatric cancer patients during treatment, and here we will probe the rationale for pursuing such studies...
October 25, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29066440/exercise-training-reveals-inflexibility-of-the-diaphragm-in-an-animal-model-of-patients-with-obesity-driven-heart-failure-with-a-preserved-ejection-fraction
#16
T Scott Bowen, Dominic Brauer, Natale P L Rolim, Fredrik H Bækkerud, Angela Kricke, Anne-Marie Ormbostad Berre, Tina Fischer, Axel Linke, Gustavo Justo da Silva, Ulrik Wisloff, Volker Adams
BACKGROUND: Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations that occur in HFpEF by using an obese cardiometabolic rat model and further assessed whether exercise training performed only after the development of overt HFpEF could reverse impairments...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29065499/an-overview-of-dietary-interventions-and-strategies-to-optimize-the-management-of-non-alcoholic-fatty-liver-disease
#17
REVIEW
Brandon J Perumpail, Rosann Cholankeril, Eric R Yoo, Donghee Kim, Aijaz Ahmed
Aim: To investigate the efficacy of lifestyle adjustment strategies as a preventive measure and/or treatment of obesity-related non-alcoholic fatty liver disease in adults. Method: A systematic review of literature through 1 July 2017 on the PubMed Database was performed. A comprehensive search was conducted using key terms, such as non-alcoholic fatty liver disease (NAFLD), combined with lifestyle intervention, diet, and exercise. All of the articles and studies obtained from the search were reviewed. Redundant literature was excluded...
October 22, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29062536/involving-seldom-heard-groups-in-a-ppi-process-to-inform-the-design-of-a-proposed-trial-on-the-use-of-probiotics-to-prevent-preterm-birth-a-case-study
#18
Juliet Rayment, Rosemary Lanlehin, Christine McCourt, Shahid M Husain
PLAIN ENGLISH SUMMARY: When designing clinical trials it is important to involve members of the public, who can provide a view on what may encourage or prevent people participating and on what matters to them. This is known as Public and Patient Involvement (PPI). People from minority ethnic groups are often less likely to take part in clinical trials, but it is important to ensure they are able to participate fully so that health research and its findings are relevant to a wide population...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29060719/development-and-assessment-of-a-novel-ankle-rehabilitation-system-for-stroke-survivors
#19
Beom-Chan Lee, Dae-Hee Kim, Younsun Son, Kap-Ho Seo, Sung Ho Park, Dongyual Yoo, Alberto Fung
Spasticity after stroke is a common occurrence and requires treatment with rehabilitative regimens (e.g., stretching exercise). Unfortunately, many challenges (e.g., cost, limited availability of physical therapists, limited access to clinical facilities, etc.) can restrict participation in these rehabilitation regimens. Assistive technologies using robotic systems have been developed to provide an alternative to assist with rehabilitative exercises. However, existing assistive technologies are rarely available in clinical settings due to technical limitations (e...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29037627/does-ultrasound-therapy-add-to-the-effects-of-exercise-and-mobilization-in-frozen-shoulder-a-pilot-randomized-double-blind-clinical-trial
#20
Safoora Ebadi, Bijan Forogh, Ehsan Fallah, Arash Babaei Ghazani
OBJECTIVE: This study intended to determine the extent to which Ultrasound could add to the effects of exercise and manual therapy in the rehabilitation treatment of primary adhesive capsulitis. DESIGN: A pilot double blind randomized clinical trial was carried out on 50 patients suffering from primary adhesive capsulitis. Intervention included continuous 3 MHz, 1.5 w/cm(2) Ultrasound, applied for the first group and sham Ultrasound for the second group. In addition specific stretching and strengthening exercises as well as glenohumeral joint mobilization were delivered to both groups...
October 2017: Journal of Bodywork and Movement Therapies
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