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Histiocytoid sweet syndrome

Victoria Alegría-Landa, Lorenzo Cerroni, Luis Requena
No abstract text is available yet for this article.
August 1, 2017: JAMA Dermatology
Marie Dominique Vignon-Pennamen, Amélie Osio, Maxime Battistella
No abstract text is available yet for this article.
August 1, 2017: JAMA Dermatology
Sheila Requena López, Cayetana Maldonado Seral, Maria Paz González Gutiérrez
No abstract text is available yet for this article.
March 18, 2017: Medicina Clínica
Renata Marcarini, Raquel Nardelli de Araujo, Monisa Martins Nóbrega, Karina Bittencourt Medeiros, Alexandre Carlos Gripp, Juan Manuel Piñeiro Maceira
Histiocytoid Sweet's Syndrome is a rare inflammatory disease described in 2005 as a variant of the classical Sweet's Syndrome (SS). Histopathologically, the dermal inflammatory infiltrate is composed mainly of mononuclear cells that have a histiocytic appearance and represent immature myeloid cells. We describe a case of Histiocytoid Sweet's Syndrome in an 18-year-old man. Although this patient had clinical manifestations compatible with SS, the cutaneous lesions consisted of erythematous annular plaques, which are not typical for this entity and have not been described in histiocytic form so far...
September 2016: Anais Brasileiros de Dermatologia
Victoria Alegría-Landa, Socorro María Rodríguez-Pinilla, Angel Santos-Briz, José Luis Rodríguez-Peralto, Victor Alegre, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
Importance: Histiocytoid Sweet syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature. Objective: The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. We also analyze whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome...
July 1, 2017: JAMA Dermatology
Jennifer Lee, Kristine M Cornejo, Jillian Rork, Karen Rothman, April Deng
No abstract text is available yet for this article.
March 9, 2017: American Journal of Dermatopathology
Gina J Ferris, Stephanie Fabbro, Alejandro Gru, Jessica Kaffenberger
We present an original case report of a 58-year-old man with a history of histiocytoid Sweet and myelodysplastic syndrome who presented with a new onset of tender plaques on his oral commissures. A biopsy revealed a dense dermal neutrophilic infiltrate, leukocytoclasis without frank vasculitis, and, most notably, the presence of many xanthomatized cells. Clinical presentation and histologic features were most consistent with an acute neutrophilic dermatosis, which we believe to be a xanthomized variant of Sweet syndrome...
May 2017: American Journal of Dermatopathology
Christina Wlodek, Nidhi Bhatt, Cameron Kennedy
A number of neutrophilic dermatoses are associated with malignancies and their treatment. These rarely occur together in the same patient. A Caucasian 72-year-old male was treated for acute myeloid leukemia (AML) with chemotherapy including daunorubicin and cytarabine. Within 48 hours of commencing treatment, he developed pyrexia and, two days later, disseminated non-tender pink plaques on the limbs and trunk. A skin biopsy showed a dermal interstitial infiltrate of lymphocytes, histiocytoid cells and predominantly neutrophils...
July 2016: Dermatology Practical & Conceptual
Allison K Cinats, Richard M Haber
Autoimmune hepatitis is a subtle diagnosis that has many diverse clinical presentations. It has been reported in the literature to occur concomitantly with pyoderma gangrenosum, a neutrophilic dermatosis. Sweet's syndrome is another neutrophilic dermatosis and has been reported to be associated with autoimmune hepatitis in only 2 previous cases: 1 idiopathic and 1 drug induced. Here we report a third case in a 24-year-old woman diagnosed with Sweet's syndrome in association with autoimmune hepatitis, documenting a possible trend between neutrophilic dermatoses and autoimmune hepatitis...
January 2017: Journal of Cutaneous Medicine and Surgery
Lisa Ghoufi, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Walid Barhoumi, Edouard Begon, Corinne Haioun, Cécile Pautas, Florence Beckerich, Christine Robin, Pierre Wolkenstein, Catherine Cordonnier, Olivier Chosidow, Andréa Toma
Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology...
April 2016: Medicine (Baltimore)
Michael M Shalaby, Ryan R Riahi, Les B Rosen, Erik J Soine
The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histological examination reveals intense epidermal and/or dermal inflammatory infiltrates composed primarily of neutrophils without evidence of infection. The myelodysplastic syndromes consist of a heterogeneous group of malignant hematopoietic stem cell disorders characterized by dysplastic and inadequate blood cell production with a variable risk of transformation to acute leukemia. Rarely, histiocytoid Sweet's syndrome occurring in patients with myelodysplastic syndrome has been described...
January 2016: Dermatology Practical & Conceptual
James W Bush, Mark R Wick
Sweet syndrome (SS) was described over 50 years ago as a distinctive form of neutrophilic dermatosis. It may be idiopathic, drug-induced or paraneoplastic, and in the last of those subtypes, myeloproliferative diseases are prominently represented. A peculiar variant of SS is termed 'histiocytoid' SS (HSS), and early accounts of that condition asserted that it showed no linkage to hematological disorders. We herein report two additional cases of HSS--both of which were associated with myeloid dyscrasias--together with a review of the pertinent literature...
April 2016: Journal of Cutaneous Pathology
Jonathan Miller, Nicole Lee, Naveed Sami
Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported treatment response for the histiocytoid variant...
July 2015: Dermatology Online Journal
Sarah Bonazza, Bruce Dalton, Jori Hardin, Andrei Metelitsa
No abstract text is available yet for this article.
July 2015: Canadian Journal of Hospital Pharmacy
Cynthia M Magro, Shabnam Momtahen, Giang H Nguyen, Xuan Wang
BACKGROUND: Histiocytoid Sweet's syndrome was originally described as cutaneous lesions of Sweet's syndrome where the infiltrate is mostly composed of histiocytoid mononuclear cells. The putative cell has been interpreted as an immature neutrophil based on the intense expression of myeloperoxidase. METHODS: To better understand the nature of the infiltrate and potential mechanisms leading to this distinct form of cutaneous inflammatory cell influx, thirteen cases of histiocytoid Sweet's syndrome, encountered in the routine and consult practice of one of the authors, were studied...
July 2015: European Journal of Dermatology: EJD
Austin G Kulasekararaj, Shahram Kordasti, Tanya Basu, Jonathan R Salisbury, Ghulam J Mufti, Anthony W P du Vivier
Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis. It has been associated with malignant disease, especially acute myeloid leukaemia (AML), infections, autoimmune disorders and drugs, particularly granulocyte colony-stimulating factor (GCSF). No cause is found in the rest, which are labelled idiopathic. We describe 15 patients with SS, which we believe represent 'immune dysregulation' secondary to myelodysplastic syndrome (MDS). We initially identified 31 patients with SS in a cohort of 744 patients with MDS and 215 with AML seen over a 6-year period (2004-10)...
September 2015: British Journal of Haematology
Jessica Kim So, Casey A Carlos, Corey S Frucht, Philip R Cohen
BACKGROUND: Histiocytoid Sweet syndrome is an uncommon variant in which the dermal infiltrate is composed of mononuclear cells with a histiocytic appearance that represent immature myeloid cells. Giant cellulitis-like Sweet syndrome is a recently described variant characterized by relapsing widespread giant lesions. PURPOSE: We report a unique patient with histiocytoid giant cellulitis-like Sweet syndrome and review the current literature on histiocytoid Sweet syndrome and giant cellulitis-like Sweet syndrome...
March 2015: Dermatology Online Journal
Estelle Hau, Marie-Dominique Vignon Pennamen, Maxime Battistella, Anne Saussine, Maud Bergis, Benedicte Cavelier-Balloy, Michel Janier, Florence Cordoliani, Martine Bagot, Michel Rybojad, Jean-David Bouaziz
The pathophysiology of neutrophilic dermatoses (NDs) and autoimmune connective tissue diseases (AICTDs) is incompletely understood. The association between NDs and AICTDs is rare; recently, however, a distinctive subset of cutaneous lupus erythematosus (LE, the prototypical AICTD) with neutrophilic histological features has been proposed to be included in the spectrum of lupus. The aim of our study was to test the validity of such a classification. We conducted a monocentric retrospective study of 7028 AICTDs patients...
December 2014: Medicine (Baltimore)
Anna Peroni, Chiara Colato, Donatella Schena, Franco Rongioletti, Giampiero Girolomoni
BACKGROUND: Histiocytoid Sweet syndrome (HSS) is a rare variant of Sweet syndrome (SS). The nature of histiocytoid cells is still uncertain. OBJECTIVE: We sought to offer a comprehensive overview on clinical features of HSS and further information on immunohistochemical phenotype of the infiltrate. METHODS: The clinical, histologic, and immunohistochemical features of 12 of our patients with HSS and all cases retrieved through a PubMed search were analyzed...
January 2015: Journal of the American Academy of Dermatology
Chutika Srisuttiyakorn, Jennifer Reeve, Swapna Reddy, Suguru Imaeda, Rossitza Lazova
Subcutaneous histiocytoid Sweet’s syndrome is a rare variant of histiocytoid Sweet’s syndrome (SS). We present a 68-year-old woman with subcutaneous histiocytoid SS in association with refractory myelodysplastic syndrome transformed to acute myeloblastic leukemia (AML), status post induction chemotherapy and with persistent blasts (50%) in the bone marrow and blood, accompanied with neutropenia. The patient presented to the emergency room with fever and altered mental status. Clinical examination revealed approximately 20 scattered 0...
May 2014: Journal of Cutaneous Pathology
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