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https://www.readbyqxmd.com/read/29141179/formation-of-longitudinal-axon-pathways-in-caenorhabditis-elegans
#1
REVIEW
Harald Hutter
The small number of neurons and the simple architecture of the Caenorhabditis elegans (C. elegans) nervous system enables researchers to study axonal pathfinding at the level of individually identified axons. Axons in C. elegans extend predominantly along one of the two major body axes, the anterior-posterior axis and the dorso-ventral axis. This review will focus on axon navigation along the anterior-posterior axis, leading to the establishment of the longitudinal axon tracts, with a focus on the largest longitudinal axon tract, the ventral nerve cord (VNC)...
November 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29141079/visual-function-response-to-ocriplasmin-for-the-treatment-of-vitreomacular-traction-and-macular-hole-the-oasis-study
#2
Benedicte Lescrauwaet, Luc Duchateau, Thomas Verstraeten, Timothy L Jackson
Purpose: To assess the effect of ocriplasmin on visual function response (VFR) measured using visual acuity (VA) and vision-related quality of life, and to quantify the association between release of vitreomacular adhesion (VMA) at day 28 and VFR. Methods: Prespecified analysis of secondary endpoints from a randomized controlled trial. Of 220 participants with symptomatic VMA/vitreomacular traction (VMT), including VMT associated with a macular hole up to 400 μm, 146 received a single intravitreal injection of 125 μg ocriplasmin and 74 a sham injection...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29140971/effect-of-s-mutans-and-s-sanguinis-on-growth-and-adhesion-of-p-gingivalis-and-their-ability-to-adhere-to-different-dental-materials
#3
Yan Tu, Xiaolong Ling, Yadong Chen, Yuan Wang, Na Zhou, Hui Chen
BACKGROUND Caries and periodontal diseases are caused by the biofilm formed by caries- and periodontal disease-related bacteria. Specific biofilms could be formed on different filling materials in oral cavity. Thus, to explore the inhibition effect of restorative filling materials on biofilm formation is of great significance in the treatment of caries and periodontal disease. MATERIAL AND METHODS The supernatants of S. mutans, S. sanguinis, and P. gingivalis suspension were combined with BHI broth. After 24 h, the live P...
November 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29140895/an-ex-vivo-comparison-of-2-cyanoacrylate-skin-protectants
#4
Daniel J Gibson
PURPOSE: The purpose of these experiments was to compare 2 commercially available skin protectants with different chemical compositions. DESIGN: Two materially different skin protectants were applied to ex vivo pig skin, subjected to stresses, and the resulting skin was observed and analyzed. METHODS: Using ex vivo pig skin, we sought to better understand the physical differences between a cyanoacrylate-based and a mixed cyanoacrylate/acrylic polymer-based skin protectant...
November 14, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#5
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29140719/effects-of-different-etching-methods-and-bonding-procedures-on-shear-bond-strength-of-orthodontic-metal-brackets-applied-to-different-cad-cam-ceramic-materials
#6
S Kutalmış Buyuk, Ahmet Serkan Kucukekenci
OBJECTIVE: To investigate the shear bond strength (SBS) of orthodontic metal brackets applied to different types of ceramic surfaces treated with different etching procedures and bonding agents. MATERIALS AND METHODS: Monolithic CAD/CAM ceramic specimens (N = 120; n = 40 each group) of feldspathic ceramic Vita Mark II, resin nanoceramic Lava Ultimate, and hybrid ceramic Vita Enamic were fabricated (14 × 12 × 3 mm). Ceramic specimens were separated into four subgroups (n = 10) according to type of surface treatment and bonding onto the ceramic surface...
November 15, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29140679/a-green-approach-to-improving-the-strength-and-flame-retardancy-of-poly-vinyl-alcohol-clay-aerogels-incorporating-bio-based-gelatin
#7
Yu-Tao Wang, Hai-Bo Zhao, Kimberly C Degracia, Lin-Xuan Han, Hua Sun, Mingze Sun, Yu-Zhong Wang, David A Schiraldi
Bio-based gelatins were used to improve the compressive and flammability properties poly(vinyl alcohol)/montmorillonite (PVA/MMT) aerogels, fabricated using a simple and environmentally-friendly freeze-drying method. Due to the excellent compatibility and strong interfacial adhesion between PVA and gelatin, the compressive moduli of aerogels were enhanced dramatically with the incorporation of gelatin. PVA/MMT/porcine gelatin aerogels exhibit compressive modulus values as much as 12.4 MPa, nearly 300% that of the control PVA/MMT aerogel...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140375/plasma-of-argon-increases-cell-attachment-and-bacterial-decontamination-on-different-implant-surfaces
#8
Luigi Canullo, Tullio Genova, Hom-Lay Wang, Stefano Carossa, Federico Mussano
PURPOSE: This in vitro study tested the effects of argon atmospheric pressure dielectric barrier discharge (APDBD) on different implant surfaces with regard to physical changes, bacterial decontamination, and osteoblast adhesion. MATERIALS AND METHODS: Seven hundred twenty disks with three different surface topographies-machined (MAC), titanium plasma-sprayed (TPS), and zirconia-blasted and acid-etched (ZRT)-were tested in this experiment. Bacterial adhesion tests were performed repeatedly on a simplified biofilm of Streptococcus mitis...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140371/biofunctionalization-of-titanium-granules-with-simvastatin-for-improving-osteogenic-activity-and-antibacterial-properties-ex-vivo-study
#9
Zahra Gorgin Karaji, Behzad Houshmand, Shahsanam Abbasi, Sara Shafiei, Shahab Faghihi
PURPOSE: Titanium-based biomaterials present good biocompatibility, while their osseointegration and antibacterial properties need to be improved. This study aimed to enhance the bone-bonding ability of titanium-based granules, which are intended to be used as bone graft. MATERIALS AND METHODS: The titanium granules were anodized in ethylene glycol-based electrolyte and subsequently annealed to be loaded separately with simvastatin. The samples were then inspected with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) for drug loading...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140295/quantification-of-cardiovascular-disease-biomarkers-in-human-platelets-by-targeted-mass-spectrometry
#10
Sebastian Malchow, Christina Loosse, Albert Sickmann, Christin Lorenz
Platelets are known to be key players in thrombosis and hemostasis, contributing to the genesis and progression of cardiovascular diseases. Due to their pivotal role in human physiology and pathology, platelet function is regulated tightly by numerous factors which have either stimulatory or inhibitory effects. A variety of factors, e.g., collagen, fibrinogen, ADP, vWF, thrombin, and thromboxane promote platelet adhesion and aggregation by utilizing multiple intracellular signal cascades. To quantify platelet proteins for this work, a targeted proteomics workflow was applied...
November 15, 2017: Proteomes
https://www.readbyqxmd.com/read/29140181/rational-design-of-a-high-strength-bone-scaffold-platform-based-on-in-situ-hybridization-of-bacterial-cellulose-nano-hydroxyapatite-framework-and-silk-fibroin-reinforcing-phase
#11
Pei Jiang, Jiabing Ran, Pan Yan, Lingyue Zheng, Xinyu Shen, Hua Tong
Bacterial cellulose/hydroxyapatite (BC/HAp) composite had favourable bioaffinity but its poor mechanical strength limited its widespread applications in bone tissue engineering (BTE). Silk fibroin, which possesses special crystalline structure, has been widely used as organic reinforcing material, and different SFs have different amino acid sequences, which exhibit different bioaffinity and mechanical properties. In this regard, bacterial cellulose-Antheraea yamamai silk fibroin/hydroxyapatite(BC-AYSF/HAp), bacterial cellulose-Bombyx mori silk fibroin/hydroxyapatite(BC-BMSF/HAp), and BC/HAp nano-composites were synthesized via a novel in situ hybridization method...
November 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29140074/facile-and-versatile-strategy-for-construction-of-anti-inflammatory-and-antibacterial-surfaces-with-polydopamine-mediated-liposomes-releasing-dexamethasone-and-minocycline-for-potential-implants-applications
#12
Xiao Xu, Lixin Wang, Zuyuan Luo, Yaofeng Ni, Haitao Sun, Xiang Gao, Yongliang Li, Siqi Zhang, Yan Li, Shicheng Wei
Reducing early nonbacterial inflammation induced by implanted materials and infection resulting from bacterial contamination around the implant-abutment interface could greatly accelerate implant osseointegration and reduce implant failure, which would be of clinical significance. In this study, we developed a facile and versatile strategy for the construction of anti-inflammatory and antibacterial surfaces on implants, such as orthopedic/dental implants. Briefly, the surfaces of polystyrene (PS) culture plates were first coated with polydopamine and then decorated with dexamethasone plus minocycline-loaded liposomes (Dex/Mino liposomes), which was confirmed by contact angle goniometry, X-ray photoelectron spectroscopy, and fluorescence microscopy...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29139623/extracellular-proteinases-of-candida-species-pathogenic-yeasts
#13
Maria Rapala-Kozik, Oliwia Bochenska, Dorota Zajac, Justyna Karkowska-Kuleta, Mariusz Gogol, Marcin Zawrotniak, Andrzej Kozik
The increased incidence of severe disseminated infections caused by opportunistic yeast-like fungi Candida spp. highlights the urgent need for research into the major virulence factors of these pathogens - extracellular aspartic proteinases of the candidapepsin and yapsin families. Classically, these enzymes were considered to be generally destructive factors that damage host tissues and provide nutrients for pathogen propagation. However, in recent decades, novel and more specific functions have been suggested for extracellular candidal proteinases...
November 15, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29139565/leukocyte-adhesion-defect-i-rare-primary-immune-deficiency
#14
Nitesh Tewari, Vijay Prakash Mathur, Vikender Singh Yadav, Prabhat Chaudhari
Leukocyte adhesion defect I is a rare disorder (1:1,000,000) caused by diminished expression of CD-18 β2 integrins on leukocytes leading to abnormal adhesion, migration, and chemotaxis. Clinical manifestations include delayed separation of umbilical cord, omphalitis, recurrent severe infections, impaired wound healing, persistent oral ulcers, and severe periodontitis in primary and permanent dentition. A 5-year-old girl, second-born child to parents with consanguinity, presented with pain and mobility of lower teeth...
November 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29139542/temporal-and-spatial-expression-patterns-of-hedgehog-receptors-in-the-developing-inner-and-middle-ear
#15
Jeong-Oh Shin, Harinarayana Ankamreddy, Naga Mahesh Jakka, Seokwon Lee, Un-Kyung Kim, Jinwoong Bok
The mammalian inner ear is a complex organ responsible for balance and hearing. Sonic hedgehog (Shh), a member of the Hedgehog (Hh) family of secreted proteins, has been shown to play important roles in several aspects of inner ear development, including dorsoventral axial specification, cochlear elongation, tonotopic patterning, and hair cell differentiation. Hh proteins initiate a downstream signaling cascade by binding to the Patched 1 (Ptch1) receptor. Recent studies have revealed that other types of co-receptors can also mediate Hh signaling, including growth arrest-specific 1 (Gas1), cell-adhesion molecules-related/down-regulated by oncogenes (Cdon), and biregional Cdon binding protein (Boc)...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29139268/-mineral-composition-analysis-and-hemostatic-effect-of-limonitum-with-different-mineral-genesis
#16
Chao-Ying Wu, Sheng-Jin Liu, Fang Fang, Yu-Hua Wang, Wen-Guo Yang, Yu-Lu Ma, De-Kang Wu
Models were established in mice with warfarin sodium method, and their bleeding time and hemostasis time were measured by tail cutting method and slide method respectively. Rats were administered for 15 consecutive days to measure their recalcification time, plasma viscosity, platelet adhesion rate, platelet aggregation rate and other blood indexes. As compared with the blank group, the bleeding time was prolonged in model groupn(P<0.05). As compared with the model group, the results showed that the positive vitamin K, the leaching type water decoction and the sediment type decoction could significantly shorten the bleeding time (P<0...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29139209/protocol-for-a-new-concept-of-no-prep-ultrathin-ceramic-veneers
#17
Camillo D'Arcangelo, Mirco Vadini, Maurizio D'Amario, Zaccheo Chiavaroli, Francesco De Angelis
OBJECTIVES: No-prep veneers, although ideally considered the best option because of tooth structure maximum preservation, have been frequently criticized for some potential limitations including esthetic outcomes and periodontal complications. CLINICAL CONSIDERATIONS: A new protocol to optimize no-prep veneers restorations is presented. A key point of the proposed technique is to identify optimal margins' positions: margin is positioned in the point of maximum convexity of teeth, avoiding the over contouring of traditional no-prep veneers...
November 15, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29139177/a-structural-overview-of-mycobacterial-adhesins-key-biomarkers-for-diagnostics-and-therapeutics
#18
REVIEW
Flavia Squeglia, Alessia Ruggiero, Alfonso De Simone, Rita Berisio
Adherence, colonization, and survival of mycobacteria in host cells require surface adhesins, which are attractive pharmacotherapeutic targets. A large arsenal of pilus and non-pilus adhesins have been identified in mycobacteria. These adhesins are capable of interacting with host cells, including macrophages and epithelial cells and are essential to microbial pathogenesis. In the last decade, several structures of mycobacterial adhesins responsible for adhesion to either macrophages or extra cellular matrix proteins have been elucidated...
November 15, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29139022/effect-of-plasma-activated-lactated-ringer-s-solution-on-pancreatic-cancer-cells-in-vitro-and-in-vivo
#19
Yusuke Sato, Suguru Yamada, Shigeomi Takeda, Norifumi Hattori, Kae Nakamura, Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori, Yasuhiro Kodera
BACKGROUND: The medical applications of nonequilibrium atmospheric pressure plasma in cancer therapy have attracted attention. We previously reported on the antitumor effect of plasma-activated medium. However, this approach requires plasma-activated liquids that are administrable to the human body. In this study, we produced plasma-activated lactated Ringer's solution (PAL) and evaluated its antitumor effect and mechanism. Furthermore, we evaluated the effect of the intraperitoneal administration of PAL using a peritoneal dissemination mouse tumor model...
November 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29138978/-morphology-of-the-vitreoretinal-interface-in-fellow-eyes-of-patients-with-full-thickness-macular-holes
#20
J E Klaas, S Burzer, S Abraham, N Feucht, C P Lohmann, M Maier
PURPOSE: We performed a retrospective, observational clinical study to evaluate the vitreoretinal interface (VRI) in fellow eyes of patients with full thickness macular holes (FTMH) based on spectral domain optical coherence tomography (SD-OCT) examinations. METHODS: The VRI in fellow eyes of 38 patients with idiopathic FTMH, 6 of which had concomitant vitreomacular traction (VMT) and the VRI of 32 patients with FTMH with complete resolution of VMT were examined by SD-OCT for the presence of vitreomacular adhesion (VMA), VMT and the formation of FTMH, lamellar macular holes (LMH), macular pseudoholes (MPH) or epiretinal membranes (ERM)...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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