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https://www.readbyqxmd.com/read/28806150/the-puncta-enigma
#1
Daniel J Klionsky
This Editor's Corner may sound like the title of a mystery novel, but it actually reflects a question I have about the puncta articles that appear in Autophagy. In particular, I am surprised by the number of solicitations sent out for puncta that are either ignored, or, less frequently, declined. It is not that I expect the principal investigator (PI) to find the invitation to write a punctum undeniably attractive. Rather, it is the unilateral decision that it is not worthwhile for graduate students or postdocs who performed the work---and likely wrote at least the first draft of the paper---to write the punctum...
August 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28805767/-w-griesinger-a-famous-european-psychiatrist-the-200-anniversary-of-birth
#2
S A Ovsyannikov, A S Ovsyannikov
The article contains curriculum vitae of W. Griesinger and an analysis of the clinical-psychopathological approach developed by him for studying illnesses and their systematization. The stages of psychosis' progression in dynamics are shown. A clinical description of primary emerged dementia made by W. Griesinger as well as a description of the status of Grubelsucht, first discovered by the psychiatrist, are presented. The article emphasizes W. Griesinger' priority in the determination of reflexes' exclusive role in the appearance and further development of all types of mental disorders...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28804719/effect-of-2-bleaching-agents-with-a-content-of-high-concentrated-hydrogen-peroxide-on-stained-2-cad-cam-blocks-and-a-nanohybrid-composite-resin-an-afm-evaluation
#3
İzgen Karakaya, Esra Cengiz
The aim of this study was to evaluate color stability of 3 restorative materials, discoloration ability of different solutions, efficacy of 2 office bleaching agents, and surface roughness and topography. Sixty specimens for Clearfil Majesty Esthetic (CME), Lava Ultimate (LU), and Vita Enamic (VE) were prepared. They were immersed into 3 staining solutions for 2 weeks and then they were bleached. According to the measured L(⁎), a(⁎), and b(⁎) parameters described by CIELAB system, color changes (ΔE00), translucency parameters (TP), whiteness index values (W(⁎)), and changes in closeness to pure white (ΔW(⁎)) were calculated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803630/evaluation-of-the-training-capacity-of-the-spanish-resident-book-of-otolaryngology-formir-as-an-electronic-portfolio
#4
Juan Manuel Maza Solano, Gustavo Benavente Bermudo, Francisco José Estrada Molina, Jesús Ambrosiani Fernández, Serafín Sánchez Gómez
BACKGROUND: and objectives We have evaluated the training capacity of the Spanish resident training book as an electronic portfolio to achieve the learning objectives of otorhinolaryngology (ENT) residents. METHODS: A multi-method qualitative investigation with transversal characteristics, temporal and retrospective guidance was performed on Spanish ENT residents using a structured questionnaire, a semi-structured interview, and a computer application on the FORMIR website...
August 10, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28802991/volcanogenic-so2-a-natural-pollutant-measurements-modeling-and-hazard-assessment-at-vulcano-island-aeolian-archipelago-italy
#5
Domenico Granieri, Fabio Vita, Salvatore Inguaggiato
Sulfur dioxide (SO2) is a major component of magmatic gas discharges. Once emitted in the atmosphere it can affect the air and land environment at different spatial and temporal scales, with harmful effects on human health and plant communities. We used a dense dataset of continuous SO2 flux and meteorological measurements collected at Vulcano over an 8-year period spanning from May 2008 to February 2016 to model air SO2 concentrations over the island. To this end, we adopted the DISGAS (DISpersion of GAS) numerical code coupled with the Diagnostic Wind Model (DWM)...
August 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28801042/triacylglycerols-tags-in-edible-oils-determination-characterization-quantitation-chemometric-approach-and-evaluation-of-adulterations
#6
REVIEW
Serena Indelicato, David Bongiorno, Rosa Pitonzo, Vita Di Stefano, Valentina Calabrese, Sergio Indelicato, Giuseppe Avellone
Vegetable oils are a dietary source of lipids that constitute an essential component of a healthy diet. The commonly used vegetable oils differ significantly for their triacylglycerol (TAG) profile. TAGs represent the principal components of oils and may contain different fatty acids (FA) esterified with glycerol leading to several positional isomers. To differentiate individual TAGs species in edible oils, advanced analysis systems and innovative methods are therefore required. TAGs can be considered as good fingerprints for quality control and many studies have been performed to develop rapid and low cost analytical methods to determinate the authenticity, origin and eventually evidence frauds or adulterations...
August 2, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28795635/attitudes-within-the-general-population-towards-seeking-professional-help-in-cases-of-mental-distress
#7
Saska Roskar, Mark Floyd Bracic, Urska Kolar, Ksenija Lekic, Nusa Konec Juricic, Alenka Tancic Grum, Bogdan Dobnik, Vita Postuvan, Mojca Vatovec
BACKGROUND: Although effective treatment is available for a variety of mental disorders, the treatment and help-seeking gap remains high. One of the main obstacles to help-seeking behaviour is prevailing stigmatizing attitudes. AIM: To examine attitudes within the general population towards seeking professional help in times of mental distress. METHODS: A representative general population survey ( N = 594) was conducted in Slovenia by means of an Internet-based questionnaire, covering data on demographic variables and attitudes towards help-seeking behaviour...
August 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28793020/intelligent-monitoring-of-aedes-aegypti-in-a-rural-area-of-rio-de-janeiro-state-brazil
#8
Argemiro Sanavria, Claudia Bezerra da Silva, Érica Heleno Electo, Lidiane Cristina Rocha Nogueira, Sandra Maria Gomes Thomé, Isabele da Costa Angelo, Gilmar Ferreira Vita, Talles Eduardo Cabral Sanavria, Elisa Domingues Padua, Denise Glória Gaiotte
The aim of this research was to monitor the presence of females of Aedes aegypti (Linnaeus, 1762) on the Seropédica municipality, Rio de Janeiro State, from 2010 to 2013. For this purpose, the Intelligent Dengue Monitoring (IM-Dengue) and Intelligent Virus Monitoring (IM-Virus) developed by Universidade Federal de Minas Gerais (Ecovec - Minas Gerais, Brazil), were used. IM-Dengue is a tool that allows achieving a weekly overview of A. aegypti infestation, while IM-Virus is another tool that allows detecting dengue virus directly from the mosquito, by Real Time-PCR...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28781986/notch-controls-endothelial-cells
#9
EDITORIAL
Juan Rodriguez-Vita, Fabian Tetzlaff, Andreas Fischer
No abstract text is available yet for this article.
May 2017: Oncoscience
https://www.readbyqxmd.com/read/28781072/mechanical-and-optical-properties-of-monolithic-cad-cam-restorative-materials
#10
Nazmiye Sen, Yesim Olcer Us
STATEMENT OF PROBLEM: Achieving natural tooth appearance with sufficient mechanical strength is one of the most challenging issues of computer-assisted design and computer-assisted manufacturing (CAD-CAM) materials. However, limited evidence is available regarding their optical and mechanical properties for proper and evidence-based material selection in clinical practice. PURPOSE: The purpose of this in vitro study was to assess and compare the translucency and biaxial flexural strength of 5 monolithic CAD-CAM restorative materials...
August 4, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28772602/wear-behavior-of-ceramic-cad-cam-crowns-and-natural-antagonists
#11
Ella A Naumova, Stephan Schneider, Wolfgang H Arnold, Andree Piwowarczyk
OBJECTIVE: Evaluation of wear behavior of computer-aided design/computer-aided manufacturing (CAD/CAM) crowns from various restorative materials and natural antagonists. METHOD: Full CAD/CAM crowns fabricated with nanoceramic resin (Lava Ultimate (LU)), a glass ceramic in a resin interpenetrating matrix (Vita Enamic (VE)) and a lithium silicate reinforced ceramic enriched with zirconia (Vita Suprinity (VS)) were cemented on human molars. The crown and antagonists were subjected to simulated chewing...
February 28, 2017: Materials
https://www.readbyqxmd.com/read/28770706/efficacy-of-belimumab-for-the-long-term-maintenance-therapy-of-thrombocytopenia-in-systemic-lupus-erythematosus
#12
Ginevra De Marchi, Luca Quartuccio, Milena Bond, Salvatore De Vita
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July 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28769550/differences-in-gluten-protein-composition-between-old-and-modern-durum-wheat-genotypes-in-relation-to-20th-century-breeding-in-italy
#13
Michele A De Santis, Marcella M Giuliani, Luigia Giuzio, Pasquale De Vita, Alison Lovegrove, Peter R Shewry, Zina Flagella
The impact of breeding on grain yields of wheat varieties released during the 20th century has been extensively studied, whereas less information is available on the changes in gluten quality associated with effects on the amount and composition of glutenins and gliadins. In order to explore the effects of breeding during the 20th century on gluten quality of durum wheat for processing and health we have compared a set of old and modern Italian genotypes grown under Mediterranean conditions. The better technological performance observed for the modern varieties was found to be due not only to the introgression of superior alleles of high (HMW-GS) and low molecular weight (LMW-GS) glutenin subunits encoded at Glu-B1 and Glu-B3 loci, but also to differential expression of specific storage proteins...
July 2017: European Journal of Agronomy: the Journal of the European Society for Agronomy
https://www.readbyqxmd.com/read/28767704/b-abortus-rna-is-the-component-involved-in-the-down-modulation-of-mhc-i-expression-on-human-monocytes-via-tlr8-and-the-egfr-pathway
#14
M Ayelén Milillo, Lis N Velásquez, Aldana Trotta, M Victoria Delpino, Fábio V Marinho, Luciana Balboa, Mónica Vermeulen, Sonia L Espindola, Nahuel Rodriguez-Rodrigues, Gabriela C Fernández, Sergio Costa Oliveira, Guillermo H Giambartolomei, Paula Barrionuevo
Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modulating cytotoxic CD8+ T cell responses. MHC-I down-modulation depends on bacterial viability and results from the capacity of B. abortus to retain the MHC-I molecules within the Golgi apparatus. Furthermore, we recently demonstrated that epidermal growth factor receptor (EGFR) pathway is involved in this phenomenon and that this is an early event during infection...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28761725/impact-of-intervention-aimed-at-improving-the-integration-of-oncology-units-and-local-palliative-care-services-results-of-the-multicentre-prospective-sequential-mirto-study
#15
Andrea A Martoni, Barbara Melotti, Claudia Degli Esposti, Vita Mutri, Giorgio Lelli, Silvia Ansaloni, Erico Piva, Elena Strocchi, Franco Pannuti
BACKGROUND: Chemotherapy (CT) in patients with advanced cancer (ACP) near the end of life is an increasing practice of oncology units. A closer integration with palliative care (PC) services could reduce the use of potentially harmful CT. This prospective study is aimed at assessing whether a more integrated care model could reduce CT use near the end of life and increase local PC service utilisation. METHODS: The study enrolled sequentially two cohorts of ACP with an estimated life expectancy of ≤6 months...
2017: ESMO Open
https://www.readbyqxmd.com/read/28758931/tumor-stroma-crosstalk-in-bone-tissue-the-osteoclastogenic-potential-of-a-breast-cancer-cell-line-in-a-co-culture-system-and-the-role-of-egfr-inhibition
#16
Laura Mercatali, Federico La Manna, Giacomo Miserocchi, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Alberto Bongiovanni, Federica Recine, Dino Amadori, Martina Ghetti, Toni Ibrahim
Although bone metastases represent a major challenge in the natural history of breast cancer (BC), the complex interactions involved have hindered the development of robust in vitro models. The aim of this work is the development of a preclinical model of cancer and bone stromal cells to mimic the bone microenvironment. We studied the effects on osteoclastogenesis of BC cells and Mesenchymal stem cells (MSC) cultured alone or in combination. We also analyzed: (a) whether the blockade of the Epithelial Growth Factor Receptor (EGFR) pathway modified their influence on monocytes towards differentiation, and (b) the efficacy of bone-targeted therapy on osteoclasts...
July 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28756946/fragile-x-mental-retardation-protein-requirements-in-activity-dependent-critical-period-neural-circuit-refinement
#17
Caleb A Doll, Dominic J Vita, Kendal Broadie
Activity-dependent synaptic remodeling occurs during early-use critical periods, when naive juveniles experience sensory input. Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechanism based on sensory cues, with FMRP loss causing the most common heritable autism spectrum disorder (ASD), fragile X syndrome (FXS). In the well-mapped Drosophila olfactory circuitry, projection neurons (PNs) relay peripheral sensory information to the central brain mushroom body (MB) learning/memory center...
August 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28755048/contraceptive-implant-discontinuation-in-huambo-and-luanda-angola-a-qualitative-exploration-of-motives
#18
Mary Qiu, Jhony Juarez, Adelaide de Carvalho, Frederico Joao Carlos Juliana, Lucas Nhamba, Isilda Neves, Vita Vemba, Ligia Alves, Abreu Pecamena, Peter Winch
Introduction The Government of Angola is engaged in ongoing efforts to increase access to contraceptives, in particular contraceptive implants (CIs). Discontinuation of CIs, however, has been identified as being a challenge to this work, hindering the improvement of contraceptive prevalence, and in turn, maternal and child health. The objective of this study was to understand motives for contraceptive implant discontinuation in Luanda and Huambo, Angola. Methods We conducted 45 in-depth interviews and six focus groups amongst former and current contraceptive implant clients and family planning nurses in eight clinics across the provinces of Huambo and Luanda...
July 28, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28754003/estimated-nutritive-value-of-low-price-model-lunch-sets-provided-to-garment-workers-in-cambodia
#19
Jan Makurat, Aarati Pillai, Frank T Wieringa, Chhoun Chamnan, Michael B Krawinkel
BACKGROUND: The establishment of staff canteens is expected to improve the nutritional situation of Cambodian garment workers. The objective of this study is to assess the nutritive value of low-price model lunch sets provided at a garment factory in Phnom Penh, Cambodia. METHODS: Exemplary lunch sets were served to female workers through a temporary canteen at a garment factory in Phnom Penh. Dish samples were collected repeatedly to examine mean serving sizes of individual ingredients...
July 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28753467/the-association-of-scn1a-p-thr1067ala-polymorphism-with-epilepsy-risk-and-the-response-to-antiepileptic-drugs-in-slovenian-children-and-adolescents-with-epilepsy
#20
Sara Bertok, Vita Dolžan, Katja Goričar, Katarina Trebušak Podkrajšek, Tadej Battelino, Zvonka Rener-Primec
PURPOSE: The voltage-gated sodium channel SCN1A mutations are involved in epileptogenesis and may be associated with different epilepsy phenotypes. The SCN1A channel is also an important antiepileptic drug (AED) target. The aim of this study was to investigate if the SCN1A c.3184A>G/p.Thr1067Ala polymorphism modifies the epilepsy risk or is associated with the responsiveness to AEDs in Slovenian children and adolescents with epilepsy. METHODS: In total, 216 paediatric patients with epilepsy were consecutively recruited during routine outpatient follow-up visits between January 2011 and December 2014...
July 20, 2017: Seizure: the Journal of the British Epilepsy Association
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