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https://www.readbyqxmd.com/read/28436320/antibacterial-activity-of-desert-truffles-from-saudi-arabia-against-staphylococcus-aureus-and-pseudomonas-aeruginosa
#1
Domenico Schillaci, Maria Grazia Cusimano, Stella Maria Cascioferro, Vita Di Stefano, Vincenzo Arizza, Marco Chiaramonte, Luigi Inguglia, Abdulhakim Bawadekji, Salvatore Davino, Maria Letizia Gargano, Giuseppe Venturella
Medicinal mushrooms represent an unlimited source of polysaccharides with nutritional, antitumoral, antibacterial, and immune-stimulating properties. Traditional studies of epigeous higher Basidiomycetes have recently been joined by studies of hypogeous fungi and, in particular, of so-called desert truffles. With the aim to obtain novel agents against bacteria of clinical importance, we focused on the edible desert truffle mushrooms Tirmania pinoyi, Terfezia claveryi, and Picoa juniperi as sources of new antimicrobial agents...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28435363/lightness-chroma-and-hue-distributions-in-natural-teeth-measured-by-a-spectrophotometer
#2
Teuta Pustina-Krasniqi, Kujtim Shala, Gloria Staka, Teuta Bicaj, Enis Ahmedi, Linda Dula
OBJECTIVE: The aim of the study was to analyze the distribution of color parameters, lightness (L*), chroma (C), hue (H), a* and b*, in the intercanine sector in maxilla. MATERIAL AND METHODS: Patients' tooth color measurements were performed using an intraoral spectrophotometer VITA Easyshade(®) (VITA Zahnfabrik H. Rauter GmbH and Co. KG, Bad Sackingen, Germany). The measurements were made in 255 subjects in the intercanine sector in maxilla. RESULTS: The mean values for the group of 255 subjects were as follows: L*, a*, b*, C, and H as 81...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#3
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28426845/her2-specific-chimeric-antigen-receptor-modified-virus-specific-t-cells-for-progressive-glioblastoma-a-phase-1-dose-escalation-trial
#4
Nabil Ahmed, Vita Brawley, Meenakshi Hegde, Kevin Bielamowicz, Mamta Kalra, Daniel Landi, Catherine Robertson, Tara L Gray, Oumar Diouf, Amanda Wakefield, Alexia Ghazi, Claudia Gerken, Zhongzhen Yi, Aidin Ashoori, Meng-Fen Wu, Hao Liu, Cliona Rooney, Gianpietro Dotti, Adrian Gee, Jack Su, Yvonne Kew, David Baskin, Yi Jonathan Zhang, Pamela New, Bambi Grilley, Milica Stojakovic, John Hicks, Suzanne Z Powell, Malcolm K Brenner, Helen E Heslop, Robert Grossman, Winfried S Wels, Stephen Gottschalk
Importance: Glioblastoma is an incurable tumor, and the therapeutic options for patients are limited. Objective: To determine whether the systemic administration of HER2-specific chimeric antigen receptor (CAR)-modified virus-specific T cells (VSTs) is safe and whether these cells have antiglioblastoma activity. Design, Setting, and Participants: In this open-label phase 1 dose-escalation study conducted at Baylor College of Medicine, Houston Methodist Hospital, and Texas Children's Hospital, patients with progressive HER2-positive glioblastoma were enrolled between July 25, 2011, and April 21, 2014...
April 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28426366/notch1-induces-endothelial-senescence-and-promotes-tumor-progression
#5
Juan Rodriguez-Vita, Andreas Fischer
No abstract text is available yet for this article.
April 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28423905/abbreviated-curriculum-vitae-of-klaus-schulten
#6
Klaus Schulten
No abstract text is available yet for this article.
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28422153/clinical-pharmacogenetic-models-for-personalized-cancer-treatment-application-to-malignant-mesothelioma
#7
Katja Goričar, Viljem Kovač, Vita Dolžan
Large interindividual differences in treatment outcome are observed in cancer patients undergoing chemotherapy. Our aim was to develop and validate clinical-pharmacogenetic prediction models of gemcitabine/cisplatin or pemetrexed/cisplatin treatment outcome and develop an algorithm for genotype-based treatment recommendations in malignant mesothelioma (MM). We genotyped 189 MM patients for polymorphisms in gemcitabine, pemetrexed and cisplatin metabolism, transport and drug target genes and DNA repair pathways...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420323/study-protocol-insight-46-a-neuroscience-sub-study-of-the-mrc-national-survey-of-health-and-development
#8
Christopher A Lane, Thomas D Parker, Dave M Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M Jorge Cardoso, Ana Carvalho, Jessica Collins, Enrico De Vita, John C Dickson, Norah Epie, Miklos Espak, Susie M D Henley, Chandrashekar Hoskote, Michael Hutel, Jana Klimova, Ian B Malone, Pawel Markiewicz, Andrew Melbourne, Marc Modat, Anette Schrag, Sachit Shah, Nikhil Sharma, Carole H Sudre, David L Thomas, Andrew Wong, Hui Zhang, John Hardy, Henrik Zetterberg, Sebastien Ourselin, Sebastian J Crutch, Diana Kuh, Marcus Richards, Nick C Fox, Jonathan M Schott
BACKGROUND: Increasing age is the biggest risk factor for dementia, of which Alzheimer's disease is the commonest cause. The pathological changes underpinning Alzheimer's disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment - including β-amyloid depostion, vascular disease, network breakdown and atrophy - to be assessed repeatedly and non-invasively...
April 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28416198/engineering-human-renal-epithelial-cells-for-transplantation-in-regenerative-medicine
#9
Vita Manzoli, David C Colter, Sridevi Dhanaraj, Alessia Fornoni, Camillo Ricordi, Antonello Pileggi, Alice A Tomei
Cellular transplantation may treat several human diseases by replacing damaged cells and/or providing a local source of trophic factors promoting regeneration. We utilized human renal epithelial cells (hRECs) isolated from cadaveric donors as a cell model. For efficacious implementation of hRECs for treatment of kidney diseases, we evaluated a novel encapsulation strategy for immunoisolation of hRECs and lentiviral transduction of the Green Fluorescent Protein (GFP) as model gene for genetic engineering of hRECs to secrete desired trophic factors...
April 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28415567/efficacy-and-safety-of-t-dm1-in-the-common-practice-of-her2-advanced-breast-cancer-setting-a-multicenter-study
#10
Alessandra Fabi, Michelino De Laurentiis, Michele Caruso, Enrichetta Valle, Luca Moscetti, Daniele Santini, Katia Cannita, Luisa Carbognin, Mariangela Ciccarese, Rosalba Rossello, Grazia Arpino, Vita Leonardi, Filippo Montemurro, Nicla La Verde, Daniele Generali, Alberto Zambelli, Giuseppa Scandurra, Michelangelo Russillo, Ida Paris, Anna Maria D'Ottavio, Gianfranco Filippelli, Marianna Giampaglia, Simonetta Stani, Agnese Fabbri, Daniele Alesini, Daniela Cianniello, Diana Giannarelli, Francesco Cognetti
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (mBC). The aim of this 'field-practice' study was to investigate the efficacy and safety of T-DM1, focusing on treatment line, previous lapatinib treatment and patterns of metastasis. Three hundred and three patients with HER2-positive mBC who received T-DM1 were identified by reviewing the medical records of 24 Italian Institutions...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410137/flag-tagged-cd19-specific-car-t-cells-eliminate-cd19-bearing-solid-tumor-cells-in-vitro-and-in-vivo
#11
Robert Berahovich, Shirley Xu, Hua Zhou, Hizkia Harto, Qumiao Xu, Andres Garcia, Fenyong Liu, Vita M Golubovskaya, Lijun Wu
Autologous T cells expressing chimeric antigen receptors (CARs) specific for CD19 have demonstrated remarkable efficacy as therapeutics for B cell malignancies. In the present study, we generated FLAG-tagged CD19-specific CAR-T cells (CD19-FLAG) and compared them to their non-tagged counterparts for their effects on solid and hematological cancer cells in vitro and in vivo. For solid tumors, we used HeLa cervical carcinoma cells engineered to overexpress CD19 (HeLa-CD19), and for hematological cancer we used Raji Burkitt's lymphoma cells, which endogenously express CD19...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28406825/outcome-evaluation-after-2023-nipple-sparing-mastectomies-our-experience
#12
Roy De Vita, Giovanni Zoccali
No abstract text is available yet for this article.
April 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28398405/-gastric-carcinoma-an-evolutionary-scenario
#13
Fabio Gelsomino, Andrea Spallanzani, Ferdinando De Vita, Maria Di Bartolomeo, Cecilia Gavazzi, Lorenza Rimassa, Stefano Cascinu
Despite the progressive decline of its incidence and mortality over the past decades, gastric cancer remains the forth most common cause of cancer-related death in Europe. While historically gastric adenocarcinoma has been classified according to the Lauren classification in intestinal and diffuse subtype, the knowledge of the complex molecular mechanisms underlying its carcinogenesis has led to new molecular classifications which can represent the starting point for the development of a personalized approach also in this disease...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28393276/leukocyte-telomere-length-is-linked-to-vascular-risk-factors-not-to-alzheimer-s-disease-in-the-vita-study
#14
Margareta Hinterberger, Peter Fischer, Klaus Huber, Walter Krugluger, Sonja Zehetmayer
Association of telomere shortening with overall dementia or Alzheimer's disease is described controversially and the pathophysiologic relevance is unclear. Whether patients, suffering from pure probable Alzheimer's disease or pure vascular dementia, have shorter leukocyte telomeres than cognitively healthy controls was determined. Leukocyte telomere lengths (LTLs) of 597 participants of the VITA study (longitudinal community-based age-cohort [mean 75.7 (±0.45) years] study: 243 male; 578 non-demented at baseline) were compared with different aspects of cognition, risk factors of dementia and survival...
April 9, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28391968/bullying-victimization-and-suicide-ideation-and-behavior-among-adolescents-in-europe-a-10-country-study
#15
Shira Barzilay, Anat Brunstein Klomek, Alan Apter, Vladimir Carli, Camilla Wasserman, Gergö Hadlaczky, Christina W Hoven, Marco Sarchiapone, Judit Balazs, Agnes Kereszteny, Romuald Brunner, Michael Kaess, Julio Bobes, Pilar Saiz, Doina Cosman, Christian Haring, Raphaela Banzer, Paul Corcoran, Jean-Pierre Kahn, Vita Postuvan, Tina Podlogar, Merike Sisask, Airi Varnik, Danuta Wasserman
PURPOSE: To examine risk and protective factors moderating the associations between three types of bullying victimization (physical, verbal, and relational bullying) with suicide ideation/attempts in a large representative sample of European adolescents. METHODS: We analyzed cross-sectional data on 11,110 students (mean age = 14.9, standard deviation = .89) recruited from 168 schools in 10 European Union countries involved in the Saving and Empowering Young Lives in Europe study...
April 5, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28388548/safety-and-efficacy-of-p62-dna-vaccine-elenagen-in-a-first-in-human-trial-in-patients-with-advanced-solid-tumors
#16
Dmitry M Ponomarenko, Irina D Klimova, Yulia A Chapygina, Viktoria V Dvornichenko, Natalia V Zhukova, Rashida V Orlova, Georgy M Manikhas, Alexandr V Zyryanov, Lilya A Burkhanova, Irina I Badrtdinova, Basile N Oshchepkov, Elena V Filippova, Sergei V Orlov, Sergei I Kolesnikov, Albert A Sufianov, Svetlana R Baum, Olga Y Zaitzeva, Andrey B Komissarov, Mikhail P Grudinin, Oleg I Kiselev, Anatoly F Tsyb, Franco Venanzi, Vita Shcherbinina, Andrey Chursov, Vladimir L Gabai, Alexander M Shneider
Elenagen is a plasmid encoding p62/SQSTM1, the first DNA vaccine possessing two mutually complementing mechanisms of action: it elicits immune response against p62 and mitigates systemic chronic inflammation. Previously, Elenagen demonstrated anti-tumor efficacy and safety in rodent tumor models and spontaneous tumors in dogs. This multicenter I/IIa trial evaluated safety and clinical activity of Elenagen in patients with advanced solid tumors. Fifteen patients were treated with escalating doses of Elenagen (1- 5 mg per doses, 5 times weekly) and additional 12 patients received 1 mg dose...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387186/efficacy-of-10-percent-carbamide-peroxide-as-an-intracoronal-bleaching-agent-in-nonvital-discolored-primary-teeth-an-in-vitro-study
#17
Miram Abd El Magied Shaheen, Mona Abdallah Elkateb, Niveen Samir Bakry, Omar Abd El Sadek El Meligy
PURPOSE: The purpose of this study was to evaluate, in vitro, the efficacy of 10 percent carbamide peroxide used as an intracoronal bleaching agent in blood-stained primary teeth. METHODS: Thirty extracted primary canines were stained using rabbit blood and randomly divided into two groups of 15 teeth each. Stained teeth in the test group were bleached intracoronally using 10 percent carbamide peroxide for 21 days. The bleaching agent was replaced at days seven and 14...
January 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28385435/effect-of-repeated-ceramic-firings-on-the-marginal-and-internal-adaptation-of-metal-ceramic-restorations-fabricated-with-different-cad-cam-technologies
#18
Hasan Kocaağaoğlu, Haydar Albayrak, Halil Ibrahim Kilinc, Hasan Önder Gümüs
STATEMENT OF PROBLEM: The use of computer-aided design and computer-aided manufacturing (CAD-CAM) for metal ceramic restorations has increased with advances in the technology. However, little is known about the marginal and internal adaptation of restorations fabricated using laser sintering (LS) and soft milling (SM). Moreover, the effects of repeated ceramic firings on the marginal and internal adaptation of metal ceramic restorations fabricated with LS and SM is also unknown. PURPOSE: The purpose of this in vitro study was to investigate the effects of repeated ceramic firings on the marginal and internal adaptation of metal ceramic copings fabricated using the lost wax (LW), LS, and SM techniques...
April 3, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28380037/comparison-of-the-current-ajcc-tnm-numeric-based-with-a-new-anatomical-location-based-lymph-node-staging-system-for-gastric-cancer-a-western-experience
#19
Gennaro Galizia, Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Anna Diana, Paolo Castellano, Ferdinando De Vita, Michele Orditura
BACKGROUND: In gastric cancer, the current AJCC numeric-based lymph node staging does not provide information on the anatomical extent of the disease and lymphadenectomy. A new anatomical location-based node staging, proposed by Choi, has shown better prognostic performance, thus soliciting Western world validation. STUDY DESIGN: Data from 284 gastric cancers undergoing radical surgery at the Second University of Naples from 2000 to 2014 were reviewed. The lymph nodes were reclassified into three groups (lesser and greater curvature, and extraperigastric nodes); presence of any metastatic lymph node in a given group was considered positive, prompting a new N and TNM stage classification...
2017: PloS One
https://www.readbyqxmd.com/read/28379527/characterization-of-systemic-disease-in-primary-sj%C3%A3-gren-s-syndrome-eular-ss-task-force-recommendations-for-articular-cutaneous-pulmonary-and-renal-involvements
#20
Ramos-Casals Manuel, Brito-Zerón Pilar, Seror Raphaèle, Bootsma Hendrika, Bowman Simon J, Dörner Thomas, Gottenberg Jacques-Eric, Mariette Xavier, Theander Elke, Bombardieri Stefano, De Vita Salvatore, Mandl Thomas, Ng Wan-Fai, Kruize Aike, Tzioufas Athanasios, Vitali Claudio
No abstract text is available yet for this article.
March 29, 2017: Rheumatology
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