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https://www.readbyqxmd.com/read/28105159/small-bowel-metastasis-from-pancreatic-cancer-in-a-long-term-survival-patient-with-synchronous-advanced-malignant-pleural-mesothelioma-a-case-report-and-literature-review
#1
Morena Fasano, Carminia Maria Della Corte, Giovanni Vicidomini, Valerio Scotti, Pier Francesco Rambaldi, Alfonso Fiorelli, Marina Accardo, Ferdinando De Vita, Mario Santini, Fortunato Ciardiello, Floriana Morgillo
Diffuse malignant pleural mesothelioma (MPM) is an aggressive tumor that originates from the surface of the pleura. Approximately 70% of cases are associated with chronic asbestos exposure. MPM is regarded as an incurable disease, with a median survival of ~2 years following intensive multimodality treatment. Pancreatic cancer is a malignancy also associated with a poor prognosis, with only 2% of patients surviving for 5 years. The majority of patients with pancreatic cancer are diagnosed with an advanced stage of disease and experience a poor response to therapy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28089394/grinding-damage-assessment-for-cad-cam-restorative-materials
#2
Philippe Curran, Maria Cattani-Lorente, H W Anselm Wiskott, Stéphane Durual, Susanne S Scherrer
OBJECTIVES: To assess surface/subsurface damage after grinding with diamond discs on five CAD-CAM restorative materials and to estimate potential losses in strength based on crack size measurements of the generated damage. METHODS: The materials tested were: Lithium disilicate (LIT) glass-ceramic (e.max CAD), leucite glass-ceramic (LEU) (Empress CAD), feldspar ceramic (VM2) (Vita Mark II), feldspar ceramic-resin infiltrated (EN) (Enamic) and a composite reinforced with nano ceramics (LU) (Lava Ultimate)...
January 12, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28089331/evaluation-of-marginal-and-internal-adaptation-of-hybrid-and-nanoceramic-systems-with-microcomputed-tomography-an-in%C3%A2-vitro-study
#3
Güler Yildirim, Ismail H Uzun, Ali Keles
STATEMENT OF PROBLEM: The accuracy of recently introduced chairside computer-aided design and computer-aided manufacturing (CAD-CAM) blocks is not well established, and marginal integrity and internal adaptation are not known. PURPOSE: The purpose of this in vitro study was to evaluate the marginal and internal adaptation of hybrid and nanoceramics using microcomputed tomography (μ-CT). MATERIAL AND METHODS: The marginal and internal adaptation of 3 polymer-infiltrated ceramic-network (PICN) materials (Vita Enamic [VE]; Lava Ultimate [LU]; Vita Suprinity [VS]) were compared with lithium disilicate (IPS e...
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28088377/intracapsular-hip-fractures-in-the-elderly-do-we-know-what-is-important
#4
Diana Crego-Vita, Coral Sanchez-Perez, Jose Adolfo Orellana Gomez-Rico, Celia Clemente de Arriba
BACKGROUND: Hip fractures in the elderly are a common reason for admission to the department of orthopaedic surgery, this condition asks an important part of health resources and is associated with high levels of co-morbidity and mortality. Many improvements have been introduced in the treatment of these patients, preoperative regional analgesia, intensive physical therapy, interdisciplinary care program; but still remain unresolved gaps. The aim of this study is to document the natural history of early versus delayed surgical intervention in elderly patients with hip fractures and to establish the prognostic factors of mortality and walking ability after discharge...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28074386/the-effect-of-ceramic-thickness-and-resin-cement-shades-on-the-color-matching-of-ceramic-veneers-in-discolored-teeth
#5
Wenzhong Xing, Xiaodong Chen, Dafei Ren, Kangru Zhan, Yining Wang
The objective of this study was to analyze the effects of ceramic material thickness and resin cement shade on the color matching of ceramic veneers at the gray tooth structures. Seventy-two artificial maxillary right central incisor teeth (C2 shade) were prepared according to veneer tooth preparation in practice. Ceramic materials (LT, A2 shade, IPS e.max Press) were selected to fabricate the 0.50- and 0.75-mm thick veneers at the body region. The ceramic veneer specimens were bonded to the artificial teeth by the 6 shades of resin cements (Variolink Veneer: shades of HV+3, LV-2, LV-3; and RelyX(TM) Veneer: shades of WO, TR, A3)...
January 10, 2017: Odontology
https://www.readbyqxmd.com/read/28071584/major-highlights-of-the-car-tcr-summit-boston-2016
#6
Vita Golubovskaya, Robert Berahovich, Shirley Xu, Hizkia Harto, Lijun Wu
Cellular immunotherapies such as CAR-T cell therapy and TCR-T cell therapy are relatively new, highly promising approaches for the treatment of cancer. In CAR-T cell therapy, a patient's T cells are engineered to express chimeric antigen receptors targeting tumor-associated cell surface antigens. In TCR-T cell therapy, the patient's T cells are engineered to express receptors targeting intracellular antigens. This report will summarize presentations from the recent CAR-TCR summit in Boston on September 13-16, 2016...
10, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28057649/choroid-morphometric-analysis-in-non-neovascular-age-related-macular-degeneration-by-means-of-optical-coherence-tomography-angiography
#7
Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Marchese, Luigi de Vitis, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
AIMS: To describe the vascular changes in patients affected by non-neovascular age-related macular degeneration (AMD), featuring reticular pseudodrusen (RPD), drusen, or both RPD and drusen by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional observational case series. Patients with non-neovascular AMD presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28051242/a-pilot-study-about-the-oncologic-safety-of-colonic-self-expandable-metal-stents-sems-in-obstructive-colon-cancer-is-occlusion-always-better-than-silent-perforation
#8
A Zanghì, G Piccolo, A Cavallaro, E Pulvirenti, E Lo Menzo, F Cardì, M Di Vita, A Cappellani
OBJECTIVE: To evaluate the oncologic safety of colonic self-expandable metal stents (SEMS) in obstructive colon cancer. PATIENTS AND METHODS: We retrospectively reviewed all the patients who were treated with endoscopic placement of a self-expandable metallic stent (SEMS) at our institution. RESULTS: A total of 26 patients were identified during the study period, of which 24 patients (92.30%) were treated with SEMS as a bridge-to-surgery and 2 (7...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28031488/cd74-is-a-novel-transcription-regulator
#9
Naama Gil-Yarom, Lihi Radomir, Lital Sever, Matthias P Kramer, Hadas Lewinsky, Chamutal Bornstein, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Vita Mirkin, Gilgi Friedlander, Lev Shvidel, Yair Herishanu, Elias J Lolis, Shirly Becker-Herman, Ido Amit, Idit Shachar
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28027596/implementing-pharmacogenomics-in-europe-design-and-implementation-strategy-of-the-ubiquitous-pharmacogenomics-consortium
#10
Cathelijne H van der Wouden, Anne Cambon-Thomsen, Erika Cecchin, Ka-Chun Cheung, Cristina Lucía Dávila-Fajardo, Vera H Deneer, Vita Dolžan, Magnus Ingelman-Sundberg, Siv Jönsson, Mats O Karlsson, Marjolein Kriek, Christina Mitropoulou, George P Patrinos, Munir Pirmohamed, Matthias Samwald, Elke Schaeffeler, Matthias Schwab, Daniela Steinberger, Julia Stingl, Gere Sunder-Plassmann, Giuseppe Toffoli, Richard M Turner, Mandy H van Rhenen, Jesse J Swen, Henk-Jan Guchelaar
Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application into routine care remains limited. Opportunely, several implementation studies and programmes have been initiated over recent years. This article presents an overview of these studies and identifies current research gaps. Importantly, one such gap is the undetermined collective clinical utility of implementing a panel of PGx-markers into routine care, because the evidence base is currently limited to specific, individual drug-gene pairs...
December 27, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28025506/fatty-acids-in-membranes-as-homeostatic-metabolic-and-nutritional-biomarkers-recent-advancements-in-analytics-and-diagnostics
#11
REVIEW
Carla Ferreri, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Vita Larocca, Georgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Rosaria Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu
Fatty acids, as structural components of membranes and inflammation/anti-inflammatory mediators, have well-known protective and regulatory effects. They are studied as biomarkers of pathological conditions, as well as saturated and unsaturated hydrophobic moieties in membrane phospholipids that contribute to homeostasis and physiological functions. Lifestyle, nutrition, metabolism and stress-with an excess of radical and oxidative processes-cause fatty acid changes that are examined in the human body using blood lipids...
December 22, 2016: Diagnostics
https://www.readbyqxmd.com/read/28018559/color-variation-induced-by-abutments-in-the-superior-anterior-maxilla-an-in-vitro-study-in-the-pig-gingiva
#12
Ramin Atash, Mohamed-Reda Boularbah, Cetik Sibel
PURPOSE: The aim of this work is to evaluate different types of materials used for making implant abutments, by means of an in vitro study and a review of the literature, in order to identify the indications for a better choice of an implant-supported restoration in the anterior section. MATERIALS AND METHODS: 5 implant abutments were tested in a random order in the superior anterior maxilla of pig gingiva (n = 8): titanium dioxide (Nobel Biocare); zirconium dioxide, Standard BO shade (Nobel Biocare, Kloten, Switzerland); zirconium dioxide, Light BI shade (Nobel Biocare); zirconium dioxide, Intense A 3...
December 2016: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28018558/the-effects-of-different-polishing-techniques-on-the-staining-resistance-of-cad-cam-resin-ceramics
#13
Omer Sagsoz, Tevfik Demirci, Gamze Demirci, Nurdan Polat Sagsoz, Mehmet Yildiz
PURPOSE: The purposes of this study were to evaluate the staining resistance of CAD/CAM resin-ceramics polished with different techniques and to determine the effectiveness of the polishing techniques on resin-ceramics, comparing it with that of a glazed glass-ceramic. MATERIALS AND METHODS: Four different CAD/CAM ceramics (feldspathic ceramic: C-CEREC Blocs, (SIRONA) and three resin-ceramics: L-Lava Ultimate, (3M ESPE), E-Enamic, (VITA) and CS-CeraSmart, (GC)) and one light cure composite resin: ME-Clearfil Majesty Esthetic (Kuraray) were used...
December 2016: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28006713/influence-of-sodalite-zeolite-infiltration-on-the-coefficient-of-thermal-expansion-and-bond-strength-of-all-ceramic-dental-prostheses
#14
Ghassan Abdul-Hamid Naji, Ros Anita Omar, Rosiyah Yahya
In all-ceramic systems, a high incidence of veneer chip-off has been reported in clinical studies. Coefficient of thermal expansion (CTE) behaviour is one of the factors that may increase residual stress in the interface and influence the veneer/core bond strength. Therefore, this study aimed to evaluate the effect of sodalite zeolite-infiltration on the CTE behaviour and bond strength of different all-ceramic prostheses. The case-study groups were synthesized sodalite zeolite-infiltrated alumina (IA-SOD) and synthesized sodalite zeolite-infiltrated zirconia-toughened alumina (ZTA) (IZ-SOD), while the control groups were glass-infiltrated alumina (IA-glass) and glass-infiltrated ZTA (IZ-glass)...
December 15, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28005920/fortified-snack-reduced-anemia-in-rural-school-aged-children-of-haiti-a-cluster-randomized-controlled-trial
#15
Lora Iannotti, Sherlie Jean-Louis Dulience, Saminetha Joseph, Charmayne Cooley, Teresa Tufte, Katherine Cox, Jacob Eaton, Jacques Raymond Delnatus, Patricia B Wolff
BACKGROUND: Nutrition in the school-aged child matters for brain development and public policy investments globally. Our group previously conducted a trial in urban schools of Haiti to examine the effects of a fortified peanut butter snack, Vita Mamba, with limited findings for anemia. OBJECTIVE: We aimed to test the hypothesis that Vita Mamba, with systematic deworming in both study arms, would significantly reduce anemia among rural, school-aged children. METHODS: A cluster, randomized longitudinal study was conducted in two rural communities of the North-East Department of Haiti, 2014-2015...
2016: PloS One
https://www.readbyqxmd.com/read/28001090/recent-technological-advances-in-pediatric-brain-tumor-surgery
#16
Bassel Zebian, Francesco Vergani, José Pedro Lavrador, Soumya Mukherjee, William John Kitchen, Vita Stagno, Christos Chamilos, Benedetta Pettorini, Conor Mallucci
X-rays and ventriculograms were the first imaging modalities used to localize intracranial lesions including brain tumors as far back as the 1880s. Subsequent advances in preoperative radiological localization included computed tomography (CT; 1971) and MRI (1977). Since then, other imaging modalities have been developed for clinical application although none as pivotal as CT and MRI. Intraoperative technological advances include the microscope, which has allowed precise surgery under magnification and improved lighting, and the endoscope, which has improved the treatment of hydrocephalus and allowed biopsy and complete resection of intraventricular, pituitary and pineal region tumors through a minimally invasive approach...
December 21, 2016: CNS Oncology
https://www.readbyqxmd.com/read/27999480/the-effect-of-perceived-social-support-on-hemodialysis-patients-quality-of-life
#17
Margarita Alexopoulou, Natalia Giannakopoulou, Eleni Komna, Victoria Alikari, Georgia Toulia, Maria Polikandrioti
BACKGROUND: Association between perceived social support and quality of life in hemodialysis patients represents a new area of interest. AIM: The aim of this study was to explore the effect of social support on the quality of life of hemodialysis patients. MATERIAL AND METHODS: In this study 258 hemodialysis patients were enrolled. Data was collected using a questionnaire which consisted of three parts: a) the Multidimensional Scale of Perceived Social Support (MSPSS) to assess perceived social support, b) the Missoula-VITAS Quality of Life Index (MVQOLI-15) to assess quality of patients' life and c) the socio-demographic, clinical and other variables of patients...
October 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27992020/emerging-radiotherapy-technology-in-a-developing-country-a-single-brazilian-institution-assessment-of-stereotactic-body-radiotherapy-application
#18
Fabio Ynoe Moraes, Lorine Arias Bonifacio, Wellington Pimenta Neves-Junior, Samir Abdallah Hanna, Carlos Eduardo Cintra Vita Abreu, Fernando Freire Arruda, João Luis Fernandes Silva, Heloisa Andrade Carvalho
Objective: To provide a quantitative profile of the indications and use of stereotactic body radiotherapy (SBRT) in a developing country oncology-based institution. In addition, to describe the patients' and treatment characteristics, and to provide a temporal analysis. Method: SBRT patients treated from 2007 to 2015 were retrospectively evaluated by two independently investigators. Data were stratified and compared in two periods: first experience (FE) (May 2007 to April 2011), and following experience (FollowE) (May 2011 to April 2015)...
November 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27991525/bacterial-cytosolic-proteins-with-a-high-capacity-for-cu-i-that-protect-against-copper-toxicity
#19
Nicolas Vita, Gianpiero Landolfi, Arnaud Baslé, Semeli Platsaki, Jaeick Lee, Kevin J Waldron, Christopher Dennison
Bacteria are thought to avoid using the essential metal ion copper in their cytosol due to its toxicity. Herein we characterize Csp3, the cytosolic member of a new family of bacterial copper storage proteins from Methylosinus trichosporium OB3b and Bacillus subtilis. These tetrameric proteins possess a large number of Cys residues that point into the cores of their four-helix bundle monomers. The Csp3 tetramers can bind a maximum of approximately 80 Cu(I) ions, mainly via thiolate groups, with average affinities in the (1-2) × 10(17) M(-1) range...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27982228/effect-of-glaze-cooling-rate-on-mechanical-properties-of-conventional-and-pressed-porcelain-on-zirconia
#20
Diogo Longhini, Cibele Oliveira de Melo Rocha, Igor Studart Medeiros, Renata Garcia Fonseca, Gelson Luis Adabo
The aim of this study was to characterize a conventional and a pressed porcelain for zirconia core as to biaxial flexural strength (BFS), apparent fracture toughness (FT) and microstructure composition, and to investigate the effect of glaze cooling rate on the BFS of the zirconia/porcelain bilayers. Monolayers of conventional porcelain Vita VM9 and pressed porcelain Vita PM9 (n=15) (12 mm diameter x 1.2 mm thick) were prepared for the BFS test (MPa). Apparent fracture toughness (MPa.m1/2) was measured by indentation technique (n=15)...
September 2016: Brazilian Dental Journal
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