keyword
https://read.qxmd.com/read/38531211/glucagon-like-peptide-1-analogs-miracle-drugs-are-blooming
#21
REVIEW
Binbin Gong, Zhihong Yao, Chenxu Zhou, Wenxi Wang, Lidan Sun, Jing Han
Glucagon-like peptide-1 (GLP-1), secreted by L cells in the small intestine, assumes a central role in managing type 2 diabetes mellitus (T2DM) and obesity. Its influence on insulin secretion and gastric emptying positions it as a therapeutic linchpin. However, the limited applicability of native GLP-1 stems from its short half-life, primarily due to glomerular filtration and the inactivating effect of dipeptidyl peptidase-IV (DPP-IV). To address this, various structural modification strategies have been developed to extend GLP-1's half-life...
March 17, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38530948/effects-of-tirzepatide-versus-basal-insulins-in-people-with-type-2-diabetes-and-different-baseline-glycemic-patterns-post-hoc-analyses-of-the-surpass-3-and-surpass-4-trials
#22
JOURNAL ARTICLE
Francesco Giorgino, Denise R Franco, Claudia Nicolay, Andrea Hemmingway, Ángel Rodríguez, Russell J Wiese
OBJECTIVE: This post hoc analysis assessed change from baseline to week 52 in glycemic parameters for tirzepatide (5, 10, 15 mg) versus insulin degludec (SURPASS-3 trial) and glargine (SURPASS-4 trial) in people with type 2 diabetes and different baseline glycemic patterns, based on fasting serum glucose (FSG) and postprandial glucose (PPG) values. RESEARCH DESIGN AND METHODS: Participant subgroups with low FSG/low PPG, low FSG/high PPG, high FSG/low PPG, and high FSG/high PPG were defined according to the median values of these measures...
March 26, 2024: Diabetes Care
https://read.qxmd.com/read/38530928/genetic-evidence-for-distinct-biological-mechanisms-that-link-adiposity-to-type-2-diabetes-towards-precision-medicine
#23
JOURNAL ARTICLE
Angela Abraham, Madeleine Cule, Marjola Thanaj, Nicolas Basty, M Amin Hashemloo, Elena P Sorokin, Brandon Whitcher, Stephen Burgess, Jimmy D Bell, Naveed Sattar, E Louise Thomas, Hanieh Yaghootkar
We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We employed MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on type 2 diabetes. We identified five clusters of adiposity-increasing alleles associated with higher type 2 diabetes risk (unfavorable adiposity) and three clusters associated with lower risk (favorable adiposity). We then characterized each cluster based on various biomarkers, metabolites and Magnetic Resonance Imaging-based measures of fat distribution and muscle quality...
March 26, 2024: Diabetes
https://read.qxmd.com/read/38530804/senescent-adipocytes-and-type-2-diabetes-current-knowledge-and-perspective-concepts
#24
REVIEW
Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase to more than a billion in less than 20 years, which is associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs and is characterized by insulin resistance, high glucose levels, and adipocyte dysfunction, which are related to senescence. Although this type of cellular aging has beneficial biological functions, it can also act unfavorable since senescent adipocytes resist apoptosis, enhance cytokine secretion, downregulate cell identity genes, and acquire the senescence-associated secretory phenotype that renders a more oxidative environment...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38529396/safety-tolerability-pharmacokinetics-and-pharmacokinetic-pharmacodynamic-modeling-of-cetagliptin-in-patients-with-type-2-diabetes-mellitus
#25
JOURNAL ARTICLE
Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie, Feng Shao
AIMS: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with type 2 diabetes mellitus (T2DM). A population PK/PD model was developed to quantify the PK and PD characteristics of cetagliptin in patients. MATERIALS AND METHODS: 32 Chinese adults with T2DM were enrolled in this study. The subjects were randomly assigned to receive either cetagliptin (50 mg or 100 mg), placebo, or sitagliptin (100 mg) once daily for 14 days...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529395/clinical-features-of-early-onset-type-2-diabetes-and-its-association-with-triglyceride-glucose-body-mass-index-a-cross-sectional-study
#26
JOURNAL ARTICLE
Yanjuan Jiang, Xiaoyang Lai
OBJECTIVE: The incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR. METHODS: A total of 1000 adults newly diagnosed with T2D were enrolled and divided into early-onset T2D (18~40 years, N=500) and late-onset T2D groups (≥40 years, N=500)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529360/assessment-of-nutrients-intake-in-pediatrics-with-type-1-diabetes-and-dyslipidemia-in-jordan
#27
JOURNAL ARTICLE
Reema Tayyem, Hala Nawaiseh, Sara Basem Zakarneh, Yasmen Khial, Sabika Allehdan
BACKGROUND: Dyslipidemias are disorders of lipoprotein metabolism that occur during childhood and adolescence, often persist into adulthood, and increase the risk of developing atherosclerotic lesions. This study aimed to assess the potential association between nutrient intake and dyslipidemia in Jordanian pediatric patients diagnosed with type 1 diabetes mellitus. METHODS: This cross-sectional study was conducted in Amman, Jordan, and involved 90 children and adolescents diagnosed with type 1 diabetes mellitus...
2024: Adolescent Health, Medicine and Therapeutics
https://read.qxmd.com/read/38529167/new-insights-into-the-effects-of-sars-cov-2-on-metabolic-organs-a-narrative-review-of-covid-19-induced-diabetes
#28
REVIEW
Lu Li, Lin Li, Xianhui Cai, Zongfu Pan
Coronavirus disease 2019 (COVID-19)-induced new-onset diabetes has raised widespread concerns. Increased glucose concentration and insulin resistance levels were observed in the COVID-19 patients. COVID-19 patients with newly diagnosed diabetes may have worse clinical outcomes and can have serious consequences. The types and exact mechanisms of COVID-19-caused diabetes are not well understood. Understanding the direct effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pancreatic beta cells and insulin target metabolism organs, such as the liver, muscle, and adipose tissues, will provide new ideas for preventing and treating the new-onset diabetes induced by COVID-19...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38528822/maladaptive-response-following-glucose-overload-in-glut4-overexpressing-h9c2-cardiomyoblasts
#29
JOURNAL ARTICLE
Bernd Stratmann, Britta Eggers, Yvonne Mattern, Tayana Silva de Carvalho, Katrin Marcus-Alic, Diethelm Tschoepe
BACKGROUND: Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic acid pathway. However, it is still unknown how cells could overcome massive chronic glucose influx on cellular and structural level. METHODS/MATERIALS: Expression profiles of hyperglycemic, glucose transporter-4 (GLUT4) overexpressing H9C2 (KE2) cardiomyoblasts loaded with 30 mM glucose (KE230L) and wild type (WT) cardiomyoblasts loaded with 30 mM glucose (WT30L) were compared using proteomics, real-time polymerase quantitative chain reaction analysis, or Western blotting, and immunocytochemistry...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38528819/effect-of-tirzepatide-on-body-fat-distribution-pattern-in-people-with-type-2-diabetes
#30
JOURNAL ARTICLE
Bertrand Cariou, Jennifer Linge, Ian J Neeland, Olof Dahlqvist Leinhard, Mikael Petersson, Laura Fernández Landó, Ross Bray, Ángel Rodríguez
AIMS: To describe the overall fat distribution patterns independent of body mass index (BMI) in participants with type 2 diabetes (T2D) in the SURPASS-3 MRI substudy by comparison with sex- and BMI-matched virtual control groups (VCGs) derived from the UK Biobank imaging study at baseline and Week 52. METHODS: For each study participant at baseline and Week 52 (N = 296), a VCG of ≥150 participants with the same sex and similar BMI was identified from the UK Biobank imaging study (N = 40 172)...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38528483/correlation-between-insulin-resistance-and-the-rate-of-neutrophils-lymphocytes-monocytes-lymphocytes-platelets-lymphocytes-in-type-2-diabetic-patients
#31
JOURNAL ARTICLE
Yuanyuan Zhang, Huaizhen Liu
BACKGROUND: Insulin resistance (IR) was a prominent feature commonly observed in individuals with type 2 diabetes mellitus (T2DM). T2DM Individuals often exhibited a concomitant presence of low-grade chronic inflammation. In this study conducted retrospectively, the aim was to investigate the connection between neutrophils-lymphocytes rate (NLR), monocytes-lymphocytes rate (MLR), platelets-lymphocytes rate (PLR) and IR, specifically among individuals with T2DM. METHOD: This study encompassed a cohort of 405 individuals diagnosed with T2DM, comprising cases from January 2021 to November 2022...
March 25, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38528189/identification-of-hdac9-and-arrdc4-as-potential-biomarkers-and-targets-for-treatment-of-type-2-diabetes
#32
JOURNAL ARTICLE
Jing Liu, Lingzhen Meng, Zhihong Liu, Ming Lu, Ruiying Wang
We aimed to identify the key potential insulin resistance (IR)-related genes and investigate their correlation with immune cell infiltration in type 2 diabetes (T2D). The GSE78721 dataset (68 diabetic patients and 62 controls) was downloaded from the Gene Expression Omnibus database and utilized for single-sample gene set enrichment analysis. IR-related genes were obtained from the Comparative Toxicology Genetics Database, and the final IR-differentially expressed genes (DEGs) were screened by intersecting with the DEGs obtained from the GSE78721 datasets...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38528132/prevalence-of-diabetic-kidney-disease-and-the-associated-factors-among-patients-with-type-2-diabetes-in-a-multi-ethnic-asian-country
#33
JOURNAL ARTICLE
Kim Sui Wan, Noran Naqiah Hairi, Feisul Mustapha, Muhammad Fadhli Mohd Yusoff, Halizah Mat Rifin, Mastura Ismail, Foong Ming Moy, Noor Ani Ahmad
The actual prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D) in Malaysia is unknown. We aimed to determine the prevalence of DKD and its associated risk factors among T2D patients in Malaysia. An analytical cross-sectional study was conducted using the year 2022 clinical audit dataset from the National Diabetes Registry. DKD was defined as albuminuria, a decreased glomerular filtration rate, or both. Among 80,360 patients, 62.2% were female, 68.4% were Malay, and the mean age was 61...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527636/the-effect-of-a-combined-lifestyle-intervention-with-and-without-protein-drink-on-inflammation-in-older-adults-with-obesity-and-type-2-diabetes
#34
JOURNAL ARTICLE
Robert G Memelink, Rose Njemini, Minse J J de Bos Kuil, Suzan Wopereis, Johan de Vogel-van den Bosch, Josje D Schoufour, Michael Tieland, Peter J M Weijs, Ivan Bautmans
BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D. METHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples...
March 23, 2024: Experimental Gerontology
https://read.qxmd.com/read/38527400/the-redox-sensitive-gsk3%C3%AE-is-a-key-regulator-of-glomerular-podocyte-injury-in-type-2-diabetic-kidney-disease
#35
JOURNAL ARTICLE
Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role in diabetic kidney disease remains controversial. In cultured glomerular podocytes, exposure to a milieu of type 2 diabetes elicited prominent signs of podocyte injury and degeneration, marked by loss of homeostatic marker proteins like synaptopodin, actin cytoskeleton disruption, oxidative stress, apoptosis, and stress-induced premature senescence, as shown by increased staining for senescence-associated β-galactosidase activity, amplified formation of γH2AX foci, and elevated expression of mediators of senescence signaling, like p21 and p16INK4A ...
March 16, 2024: Redox Biology
https://read.qxmd.com/read/38527396/probiotics-and-synbiotics-for-glycemic-control-in-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#36
JOURNAL ARTICLE
Irene Baroni, Diletta Fabrizi, Michela Luciani, Arianna Magon, Gianluca Conte, Giada De Angeli, Giulia Paglione, Davide Ausili, Rosario Caruso
BACKGROUND & AIMS: The escalating prevalence of diabetes mellitus may benefit from add-on therapeutic approaches. Given the recognized need for an updated synthesis of the literature, this systematic review and meta-analysis aimed to synthesize and critically assess the available randomized controlled trials (RCTs) that investigate the efficacy of probiotics and synbiotics on glycemic control in patients with Type 1 (T1DM) and Type 2 (T2DM) diabetes mellitus. METHODS: Comprehensive searches were conducted on PubMed, Embase, CINAHL, Scopus, and Web of Science, focusing on adults with T1DM or T2DM...
March 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38526946/metabolic-dysfunction-associated-steatotic-liver-disease-related-hepatic-fibrosis-increases-risk-of-insulin-resistance-type-2-diabetes-and-chronic-kidney-disease
#37
JOURNAL ARTICLE
Weijing Zhang, Wen Jing Song, Weiyu Chen, Zoucheng Pan, Jiawei Zhang, Li Fan, Jie Li
Metabolic dysfunction-associated steatotic liver disease (MASLD) (previously called nonalcoholic fatty liver disease, NAFLD) is associated with cardiometabolic risk factors and chronic kidney disease (CKD). However, evidence is lacking regarding whether the severity of fibrosis is affected by these risk factors and diseases and to what degree. We aimed to determine the correlation between these factors and vibration-controlled transient elastography-determined liver stiffness measurements (LSMs) and controlled attenuation parameter (CAP) values in a sample of the US population...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526231/high-throughput-methods-for-the-discovery-of-small-molecule-modulators-of-pancreatic-beta-cell-function-and-regeneration
#38
JOURNAL ARTICLE
Sean M McCarty, Martin C Clasby, Jonathan Z Sexton
The progression of type II diabetes (T2D) is characterized by a complex and highly variable loss of beta-cell mass, resulting in impaired insulin secretion. Many T2D drug discovery efforts aimed at discovering molecules that can protect or restore beta-cell mass and function have been developed using limited beta-cell lines and primary rodent/human pancreatic islets. Various high-throughput screening methods have been used in the context of drug discovery, including luciferase-based reporter assays, glucose-stimulated insulin secretion, and high-content screening...
March 25, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38526196/a-gene-switch-platform-interfacing-with-reactive-oxygen-species-enables-transcription-fine-tuning-by-soluble-and-volatile-pharmacologics-and-food-additives
#39
JOURNAL ARTICLE
Jinbo Huang, Shuai Xue, Ana Palma Teixeira, Martin Fussenegger
Synthetic biology aims to engineer transgene switches for precise therapeutic protein control in cell-based gene therapies. However, off-the-shelf trigger-inducible gene circuits are usually switched on by single or structurally similar molecules. This study presents a mammalian gene-switch platform that controls therapeutic gene expression by a wide range of molecules generating low, non-toxic levels of reactive oxygen species (ROS). In this system, KEAP1 (Kelch-like ECH-associated protein 1) serves as ROS sensor, regulating the translocation of NRF2 (nuclear factor erythroid 2-related factor 2) to the nucleus, where NRF2 binds to  antioxidant response elements (ARE) to activate the expression of a gene of interest...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38525744/tirzepatide-and-glycemic-control-metrics-using-continuous-glucose-monitoring-in-older-patients-with-type-2-diabetes-mellitus-an-observational-pilot-study
#40
Takuya Omura, Akemi Inami, Taiki Sugimoto, Shuji Kawashima, Takashi Sakurai, Haruhiko Tokuda
This observational pilot study aimed to investigate continuous glucose monitoring (CGM) metrics in older Japanese patients with type 2 diabetes mellitus (T2DM) using a CGM system (FreeStyle Libre Pro) during the first tirzepatide administration and compare the glycemic control measures before and after the initial injection. The four patients had a mean age of 79.5 years (standard deviation [SD]: 5.8), a mean body mass index of 24.6 kg/m2 (SD: 4.7), a mean glycated hemoglobin level of 9.1% (SD: 2.1), and a mean measurement period of 10...
February 26, 2024: Geriatrics
keyword
keyword
115869
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.