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https://www.readbyqxmd.com/read/29339698/association-of-interleukin-1-gene-cluster-polymorphisms-with-coronary-slow-flow-phenomenon
#1
Ferit Onur Mutluer, Dilek Ural, Barış Güngör, Osman Bolca, Tolga Aksu
OBJECTIVE: Coronary slow flow phenomenon (CSFP) is characterized by the decreased rate of contrast progression in epicardial coronary arteries in the absence of significant coronary stenosis. Mounting evidence has showed a significant association between inflammation and CSFP severity. This study aimed to evaluate possible associations between interleukin-1 receptor antagonist (IL-1ra) gene variable number tandem repeat (VNTR), IL-1ß -511 single nucleotide (SNP), and IL-1ß+3954 SNP mutations with CSFP...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29332130/cerebrospinal-fluid-pressure-revisiting-factors-influencing-optic-nerve-head-biomechanics
#2
Yi Hua, Andrew P Voorhees, Ian A Sigal
Purpose: To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods: We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the optic nerve (CON). A total of 8340 models were studied to predict factor influences on 98 responses in a two-step process: a fractional factorial screening analysis to identify the 16 most influential factors, followed by a response surface methodology to predict factor effects in detail...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29314204/telmisartan-ameliorates-vascular-endothelial-dysfunction-in-coronary-slow-flow-phenomenon-csfp
#3
Zhe Jin, Qindong Tan, Bei Sun
Coronary slow flow phenomenon (CSFP) is a coronary microvascular disorder with an increasing morbidity, and currently, available therapies are of limited clinical value for its cure. Hence, it is urgent to find a novel approach to CSFP treatment. Several studies show that endothelial dysfunction plays a critical role in the aetiology of CSFP. Telmisartan (TMST) is a clinically available anti-hypertensive medicine and has shown its potential properties for improving vascular endothelial function. Thus, we aimed to investigate the effect of TMST on endothelial dysfunction in CSFP, Endothelial-dependent flow-mediated vasodilation, serum levels of nitric oxide, adiponectin, and endothelin-1 were surveyed before and after 3 months of TMST treatment...
January 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29142809/is-left-atrial-function-affected-by-coronary-slow-flow-a-two-dimensional-speckle-tracking-echocardiographic-study
#4
Flora Fallah, Sima Narimani, Shima Yarmohammadi, Ali Hosseinsabet, Arash Jalali
Background: The coronary slow flow phenomenon (CSFP) is the slow passage of the angiographic contrast agent to the distal portion of the coronary artery in the absence of significant stenosis. We evaluated the left atrial (LA) function in patients with the CSFP using two-dimensional speckle-tracking echocardiography (2DSTE). Methods: The LA function was compared through 2DSTE between 36 patients with the CSFP and 36 participants with a normal coronary flow. The two groups were matched for age, sex, hypertension, diabetes mellitus, and the left ventricular function...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29123886/sudden-cerebral-depression-detected-by-bispectral-index-monitoring-in-cryptococcal-meningitis-with-elevated-near-fatal-cerebrospinal-fluid-pressure
#5
Hironori Matsumoto, Suguru Annen, Kensuke Umakoshi, Jun Takeba, Satoshi Kikuchi, Yuki Nakabayashi, Naoki Moriyama, Muneaki Ohshita, Mayuki Aibiki
Case: An increase in cerebrospinal fluid pressure (CSFP) is usually prominent in cryptococcal meningitis, which has a high mortality rate, so aggressive management to control CSFP is crucial. In this case, a 40-year-old-man survived cryptococcal meningitis treated with continuous spinal drainage under bispectral index (BIS) monitoring. He unexpectedly showed hypertension, went into a coma, and even loss his light reflexes due to CSFP elevation. His BIS values had abruptly dropped before developing these symptoms, but dramatically recovered after lumbar puncture drainage, suggesting that BIS monitoring could reflect cerebral function changes due to CSFP alternations...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/28916535/spinal-cord-perfusion-pressure-predicts-neurologic-recovery-in-acute-spinal-cord-injury
#6
MULTICENTER STUDY
Jordan W Squair, Lise M Bélanger, Angela Tsang, Leanna Ritchie, Jean-Marc Mac-Thiong, Stefan Parent, Sean Christie, Christopher Bailey, Sanjay Dhall, John Street, Tamir Ailon, Scott Paquette, Nicolas Dea, Charles G Fisher, Marcel F Dvorak, Christopher R West, Brian K Kwon
OBJECTIVE: To determine whether spinal cord perfusion pressure (SCPP) as measured with a lumbar intrathecal catheter is a more predictive measure of neurologic outcome than the conventionally measured mean arterial pressure (MAP). METHODS: A total of 92 individuals with acute spinal cord injury were enrolled in this multicenter prospective observational clinical trial. MAP and CSF pressure (CSFP) were monitored during the first week postinjury. Neurologic impairment was assessed at baseline and at 6 months postinjury...
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#7
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28828024/coronary-slow-flow-phenomenon-and-atrioventricular-block-a-case-report
#8
Mohammad Masoumi, Khadije Mohammadi
The coronary slow flow phenomenon (CSFP) is characterized by a delayed coronary blood flow in the absence of an obstructive coronary artery disease. Although the relation between the CSFP and myocardial ischemia has been reported previously, there is no knowledge about the relationship between the CSFP and the conduction system disorder. In this case report, we describe a patient with the CSFP presenting with complete heart block (CHB). The patient was a middle-aged woman with a history of diabetes, hypertension, and prior Coronary Care Unit admission presenting with dizziness, lightheadedness, and presyncope...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28452313/immediate-effect-of-sublingual-isosorbide-dinitrate-in-patients-with-coronary-slow-flow-phenomenon-csfp
#9
Hossam Mansour, Hassan El Labban, Ramadan Ghaleb
No abstract text is available yet for this article.
March 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/28391369/relationship-between-lamina-cribrosa-displacement-and-trans-laminar-pressure-difference-in-papilledema
#10
Javier García-Montesinos, Francisco J Muñoz-Negrete, Victoria de Juan, Gema Rebolleda
PURPOSE: The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD). METHODS: This was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution...
June 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28389675/deformation-of-the-lamina-cribrosa-and-optic-nerve-due-to-changes-in-cerebrospinal-fluid-pressure
#11
Andrew J Feola, Baptiste Coudrillier, John Mulvihill, Diogo M Geraldes, Nghia T Vo, Julie Albon, Richard L Abel, Brian C Samuels, C Ross Ethier
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28300644/the-connective-tissue-phenotype-of-glaucomatous-cupping-in-the-monkey-eye-clinical-and-research-implications
#12
REVIEW
Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Cheri Stowell, Stuart K Gardiner, Claude F Burgoyne
In a series of previous publications we have proposed a framework for conceptualizing the optic nerve head (ONH) as a biomechanical structure. That framework proposes important roles for intraocular pressure (IOP), IOP-related stress and strain, cerebrospinal fluid pressure (CSFp), systemic and ocular determinants of blood flow, inflammation, auto-immunity, genetics, and other non-IOP related risk factors in the physiology of ONH aging and the pathophysiology of glaucomatous damage to the ONH. The present report summarizes 20 years of technique development and study results pertinent to the characterization of ONH connective tissue deformation and remodeling in the unilateral monkey experimental glaucoma (EG) model...
July 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28237144/retrospective-analysis-of-translaminar-demographic-and-physiologic-parameters-in-relation-to-papilledema-severity
#13
MULTICENTER STUDY
David Fleischman, Jennifer T Perry, R Rand Allingham, Sandra S Stinnett, Gita M Fleischman, Syndee J Givre, David A Chesnutt
OBJECTIVE: Some case reports suggest that the translaminar pressure difference is important in cases of papilledema. The purpose of this study was to determine ocular, physiologic, and demographic factors associated with papilledema severity. DESIGN: Retrospective, blinded study. PARTICIPANTS: Patients who had undergone a diagnostic lumbar puncture and had a diagnosis of papilledema in conjunction with idiopathic intracranial hypertension between 2004 and 2012 were included in the study...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28223180/biomechanical-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#14
REVIEW
Cheri Stowell, Claude F Burgoyne, Ernst R Tamm, C Ross Ethier
The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans...
April 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28063138/are-biventricular-systolic-functions-impaired-in-patient-with-coronoray-slow-flow-a-prospective-study-with-three-dimensional-speckle-tracking
#15
Tuğba Kemaloğlu Öz, Mehmet Eren, Işıl Atasoy, Tayfun Gürol, Özer Soylu, Bahadır Dağdeviren
The newly developed three dimensional speckle-tracking echocardiography (3D-STE) technology provides quick and comprehensive quantitative assessment of biventricular myocardial dynamics. The impact of coronary slow flow phenomenon (CSFP) on biventricular functions has not been comprehensively evaluated using this new technology. Therefore, the aim of this study was to evaluate the effects of CSFP on biventricular systolic functions using 3D-STE. Forty patients with CSFP and otherwise normal coronary arteries (NCAs) and 40 age- and sex-matched controls with normal coronary angiograms (CAGs) were prospectively enrolled...
May 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27907041/carotid-atherosclerosis-cerebrospinal-fluid-pressure-and-retinal-vessel-diameters-the-asymptomatic-polyvascular-abnormalities-in-community-study
#16
Jing Yan Yang, Xuan Yang, Yang Li, Jie Xu, Yong Zhou, An Xin Wang, Xiang Gao, Liang Xu, Shou Ling Wu, Wen Bin Wei, Xing Quan Zhao, Jost B Jonas
PURPOSE: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. METHODS: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC...
2016: PloS One
https://www.readbyqxmd.com/read/27760263/analysis-of-cerebrospinal-fluid-pressure-estimation-using-formulae-derived-from-clinical-data
#17
RANDOMIZED CONTROLLED TRIAL
David Fleischman, Amanda K Bicket, Sandra S Stinnett, John P Berdahl, Jost B Jonas, Ning Li Wang, Michael P Fautsch, R Rand Allingham
Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate cerebrospinal fluid pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27665327/right-ventricular-function-in-coronary-slow-flow-a-two-dimensional-speckle-tracking-echocardiographic-study
#18
Ali Hosseinsabet, Shima Yarmohamadi, Sima Narimani, Nazanin Amini-Farshidmehr
OBJECTIVE: Coronary slow-flow phenomenon (CSFP) is described as protracted passage of angiographic contrast agent to the distal portion of the epicardial coronary arteries in the absence of stenosis. Few studies have addressed the effects of this condition on right ventricular (RV) dysfunction. The present objective was to assess RV function in CSFP via 2-dimensional speckle-tracking echocardiography (2DSTE). METHODS: A total of 29 patients with CSFP and 29 participants with normal coronary flow were compared regarding RV systolic and diastolic functions...
September 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27611879/estimated-cerebrospina-fluid-pressure-and-the-5-year-incidence-of-primary-open-angle-glaucoma-in-a-chinese-population
#19
Lan Li, Cairui Li, Hua Zhong, Yijin Tao, Yuansheng Yuan, Chen-Wei Pan
PURPOSE: We aim to assess the longitudinal association between baseline estimated cerebrospinal fluid pressure (CSFP) and 5-year incident primary open angle glaucoma (POAG) in a population-based sample of Bai Chinese living in rural China. METHODS: Among the 2133 Bai Chinese aged 50 years or older who had participated in the baseline examination of the Yunnan Minority Eye Study, 1520 (71.3%) attended the follow-up examination after five years and 1485 were at risk of developing POAG...
2016: PloS One
https://www.readbyqxmd.com/read/27417037/retinal-venous-pulsation-expanding-our-understanding-and-use-of-this-enigmatic-phenomenon
#20
REVIEW
William H Morgan, Martin L Hazelton, Dao-Yi Yu
Retinal vein pulsation was first noted soon after the invention of the ophthalmoscope 170 years ago and was seen to change with cerebrospinal fluid pressure (CSFP) variation in the 1920s. The classical explanation for vein pulsation was that the cardiac cycle induced systolic peak in intraocular pressure (IOP) tended to intermittently collapse the retinal vein close to its exit in the central optic disk, causing pulsation to be counter-phase to IOP. Recently, improved ophthalmodynamometry and video recording techniques have allowed us to explore the fundamentals of retinal vein pulsation...
November 2016: Progress in Retinal and Eye Research
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