keyword
https://read.qxmd.com/read/38411683/-top-4-research-studies-of-the-month-for-italian-primary-care-physicians-february-2024
#21
JOURNAL ARTICLE
Peter K Kurotschka, Alice Serafini, Mark H Ebell
This monthly article provides a collection of summaries of the most relevant studies identified as POEMs (patient-oriented evidence that matters) for Italian primary care physicians. 1) For patients with severe fatigue at least 3 months after Covid-19 infection, cognitive behavioral therapy offers significant improvement in symptoms over care as usual. 2) Key changes in the US chronic coronary disease guideline recommendations include the following. Shortening the duration of dual antiplatelet therapy, the use of beta-blockers in patients with chronic coronary disease, not recommending fish oil or omega-3 fatty acids for secondary prevention, not using e-cigarettes as first-line agents (but as secondary agents) for smoking cessation, and incorporating sodium-glucose transport protein 2 inhibitors (Sglt-2i) and glucagon-like peptide-1 (GLP-1) receptor agonists for some patients with chronic coronary disease, including those without comorbid diabetes mellitus...
March 2024: Recenti Progressi in Medicina
https://read.qxmd.com/read/38405158/probiotic-co-supplementation-with-absorbent-smectite-for-pancreatic-beta-cell-function-in-type-2-diabetes-a-secondary-data-analysis-of-a-randomized-double-blind-controlled-trials
#22
RANDOMIZED CONTROLLED TRIAL
Maryana Savytska, Dmytro Kyriienko, Ganna Zaychenko, Danylo Ostapchenko, Tetyana Falalyeyeva, Nazarii Kobyliak
INTRODUCTION: There is growing evidence from animal and clinical studies suggesting probiotics can positively affect type 2 diabetes (T2D). In a previous randomized clinical study, we found that administering a live multistrain probiotic and absorbent smectite once a day for eight weeks to patients with T2D could reduce chronic systemic inflammatory state, insulin resistance, waist circumference and improve the glycemic profile. However, there is a lack of evidence supporting the efficacy of probiotic co-supplementation with absorbent smectite on pancreatic β-cell function in T2D...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38404857/cheese-containing-probiotic-lactobacillus-brevis-nj42-isolated-from-stingless-bee-honey-reduces-weight-gain-fat-accumulation-and-glucose-intolerance-in-mice
#23
JOURNAL ARTICLE
Nor Hazwani Mohd Hasali, Amir Izzwan Zamri, Mohd Nizam Lani, Vance Matthews, Aidilla Mubarak
BACKGROUND: The high occurrence of metabolic syndrome has driven a growing demand for natural resource-based therapeutic strategies, highlighting their potential efficacy in addressing the complexities of this condition. Probiotics are established to be useful in the prevention and treatment of diabetes and obesity. However, limited exploration exists regarding the application of the isolated Lactobacillus strain from stingless bee honey as a probiotic within dairy products, such as cheese...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38399636/novel-wild-type-pediococcus-and-lactiplantibacillus-strains-as-probiotic-candidates-to-manage-obesity-associated-insulin-resistance
#24
JOURNAL ARTICLE
Paraskevi Somalou, Eleftheria Ieronymaki, Kyriaki Feidaki, Ioanna Prapa, Electra Stylianopoulou, Katerina Spyridopoulou, George Skavdis, Maria E Grigoriou, Panayiotis Panas, Anagnostis Argiriou, Christos Tsatsanis, Yiannis Kourkoutas
As the food and pharmaceutical industry is continuously seeking new probiotic strains with unique health properties, the aim of the present study was to determine the impact of short-term dietary intervention with novel wild-type strains, isolated from various sources, on high-fat diet (HFD)-induced insulin resistance. Initially, the strains were evaluated in vitro for their ability to survive in simulated gastrointestinal (GI) conditions, for adhesion to Caco-2 cells, for bile salt hydrolase secretion, for cholesterol-lowering and cellular cholesterol-binding ability, and for growth inhibition of food-borne pathogens...
January 23, 2024: Microorganisms
https://read.qxmd.com/read/38397496/in-vitro-hypoglycemic-activities-of-lactobacilli-and-bifidobacterium-strains-from-healthy-children-s-sources-and-their-effect-on-stimulating-glp-1-secretion-in-stc-1-cells
#25
JOURNAL ARTICLE
Zhiliang Cheng, Jingru Chen, Yulong Zhang, Xinyi Li, Ning Zhang, Fei Liu, Yuehua Jiao
A long-term use of chemical drugs cannot cure type II diabetes mellitus (T2DM) and their numerous toxic side effects can be harmful to human health. In recent years, probiotics have emerged as a natural resource to replace chemical drugs in alleviating many human ailments. Healthy children's intestines have a lot of colonized Lactobacilli and Bifidobacterium , and these beneficial bacteria can help promote overall health. The objective of this study was to isolate potential antidiabetic probiotic strains from healthy children and evaluate their application prospects...
February 7, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38382867/potential-of-postbiotics-for-the-treatment-of-metabolic-disorders
#26
REVIEW
Neeraj Mishra, Ashish Garg, Sumel Ashique, Shvetank Bhatt
Postbiotics, the next generation of probiotics, are extracts that are free of living and nonviable bacteria and show strong modulatory effects on the gut flora. Examples include vitamin B12, vitamin K, folate, lipopolysaccharides, enzymes, and short-chain fatty acids (SCFAs), representing a subset of essential nutrients commonly found in the human diet. Postbiotics have been observed to demonstrate antiobesity and antidiabetic effects through a variety of mechanisms. These pathways primarily involve an elevation in energy expenditure, a decrease in the formation and differentiation of adipocytes and food intake, modification of lipid and carbohydrate absorption and metabolism, and regulation of gut dysbiosis...
February 19, 2024: Drug Discovery Today
https://read.qxmd.com/read/38381517/gut-microbiota-and-nutrition-strategies-for-the-prevention-and-treatment-of-type-2-diabetes
#27
REVIEW
Maria Sastre, Alessandra Cimbalo, Jordi Mañes, Lara Manyes
The prevalence of diabetes has increased in last decades worldwide and is expected to continue to do so in the coming years, reaching alarming figures. Evidence have shown that patients with type 2 diabetes (T2D) have intestinal microbial dysbiosis. Moreover, several mechanisms link the microbiota with the appearance of insulin resistance and diabetes. Diet is a crucial factor related to changes in the composition, diversity, and activity of gut microbiota (GM). In this review, the current and future possibilities of nutrient-GM interactions as a strategy to alleviate T2D are discussed, as well as the mechanisms related to decreased low-grade inflammation and insulin resistance...
February 2024: Journal of Medicinal Food
https://read.qxmd.com/read/38369241/a-narrative-review-about-cognitive-impairment-in-metabolic-dysfunction-associated-liver-disease-masld-another-matter-to-face-through-a-holistic-approach
#28
REVIEW
Marica Meroni, Miriam Longo, Erika Paolini, Paola Dongiovanni
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic hepatic disorder worldwide in both adults and children. It is well established that MASLD represents the hepatic manifestation of the metabolic syndrome whose definition includes the presence of obesity, type 2 diabetes (T2D), dyslipidemia, hypertension and hypercoagulability. All these conditions contribute to a chronic inflammatory status which may impact on blood brain barrier (BBB) integrity leading to an impaired function of central nervous system (CNS)...
February 16, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38360226/gut-microbiota-modulation-prebiotic-and-bioactive-characteristics-of-date-pomace-polysaccharides-extracted-by-microwave-assisted-deep-eutectic-solvent
#29
JOURNAL ARTICLE
Gafar Babatunde Bamigbade, Athira Jayasree Subhash, Basel Al-Ramadi, Afaf Kamal-Eldin, Ren-You Gan, Shao Quan Liu, Mutamed Ayyash
This study investigated the characteristics of polysaccharides from date pomace using microwave-assisted deep eutectic solvents. The impact on the gut microbiota and probiotics growth was examined in vitro. The study also examined its antioxidant properties, ability to inhibit enzymes linked to diabetes and high blood pressure, impact on cell growth, and physical properties. The isolated MPS had an average molecular weight of 8073.38 kDa and contained mannose, galacturonic acid, galactose, glucose, and fructose in specific proportions...
February 13, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38359319/use-of-probiotics-and-similar-in-pediatric-patients-with-type-1-diabetes-mellitus-a-systematic-review
#30
JOURNAL ARTICLE
Luisa Pinheiro Neiva, Luiza Correia Lopez, Rafaela Orsi Pasiani, Mayco José Reinaldi Serra, Vera Esteves Vagnozzi Rullo
OBJECTIVE: To perform a systematic review of randomized controlled trials, evaluating the effect of probiotics, prebiotics or symbiotics supplementation on glycemic and inflammatory control in children with Type 1 Diabetes Mellitus (T1DM). DATA SOURCE: The Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Clinical Trials, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and Scientific Electronic Library Online (SciELO) databases were searched...
2024: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/38358546/a-study-on-the-association-between-gut-microbiota-inflammation-and-type-2-diabetes
#31
JOURNAL ARTICLE
Nannan Liu, Xuehua Yan, Bohan Lv, Yanxiang Wu, Xuehong Hu, Chunyan Zheng, Siyu Tao, Ruxue Deng, Jinfang Dou, Binfang Zeng, Guangjian Jiang
Type 2 diabetes mellitus (T2DM) was reported to be associated with impaired immune response and alterations in microbial composition and function. However, the underlying mechanism remains elusive. To investigate the association among retinoic acid-inducible gene-I-like receptors (RLRs) signaling pathway, intestinal bacterial microbiome, microbial tryptophan metabolites, inflammation, and a longer course of T2DM, 14 patients with T2DM and 7 healthy controls were enrolled. 16S rRNA amplicon sequencing and untargeted metabolomics were utilized to analyze the stool samples...
February 15, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38345666/probiotic-yogurt-supplemented-with-lactococcus-lactis-r7-and-red-guava-extract-bioaccessibility-of-phenolic-compounds-and-influence-in-antioxidant-activity-and-action-of-alpha-amylase-and-alpha-glucosidase-enzymes
#32
JOURNAL ARTICLE
Elisa Dos Santos Pereira, Chirle de Oliveira Raphaelli, Khadija Bezerra Massaut, Taiane Mota Camargo, Marjana Radünz, Jéssica Fernanda Hoffmann, Márcia Vizzotto, Simone Pieniz, Ângela Maria Fiorentini
The industry has increasingly explored the development of foods with functional properties, where supplementation with probiotics and bioactive compounds has gained prominence. In this context, the study aimed to evaluate the influence of in vitro biological digestion on the content of phenolic compounds, antioxidant activity, and inhibition of α-amylase and α-glucosidase activities of probiotic yogurt supplemented with the lactic acid bacteria Lactococcus lactis R7 and red guava extract (Psidium cattleianum)...
February 12, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38343539/role-of-the-intestinal-microbiome-and-its-therapeutic-intervention-in-cardiovascular-disorder
#33
REVIEW
Ameer Luqman, Adil Hassan, Mehtab Ullah, Sahar Naseem, Mehraj Ullah, Liyuan Zhang, Ahmad Ud Din, Kamran Ullah, Waqar Ahmad, Guixue Wang
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium, and its impact on human health can be altered by a variety of factors such as external variables, social behavior, age, nutrition, and genetics. Gut microbes' imbalances are related to a variety of chronic diseases including cancer, obesity, and digestive disorders. Globally, recent findings show that intestinal microbes have a significant role in the formation of cardiovascular disease (CVD), which is still the primary cause of fatalities...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38340656/immunological-aspects-of-probiotics-for-improving-skin-diseases-influence-on-the-gut-brain-skin-axis
#34
REVIEW
Ali Abdi, Parvin Oroojzadeh, Nassim Valivand, Roshanak Sambrani, Hajie Lotfi
The interplay between gut microbiota and human health, both mental and physical, is well-documented. This connection extends to the gut-brain-skin axis, linking gut microbiota to skin health. Recent studies have underscored the potential of probiotics and prebiotics to modulate gut microbiota, supported by in vivo and clinical investigations. In this comprehensive review, we explore the immunological implications of probiotics in influencing the gut-skin axis for the treatment and prevention of skin conditions, including psoriasis, acne, diabetic ulcers, atopic dermatitis, and skin cancer...
February 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38338581/an-update-on-prebiotics-and-on-their-health-effects
#35
REVIEW
Antonio Bevilacqua, Daniela Campaniello, Barbara Speranza, Angela Racioppo, Milena Sinigaglia, Maria Rosaria Corbo
Prebiotic compounds were originally defined as "a nondigestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, and thus improves host health"; however, a significant modulation of the definition was carried out in the consensus panel of The International Scientific Association for Probiotics and Prebiotics (ISAPP), and the last definition states that "prebiotics are substrates that are selectively utilized by host microorganisms conferring a health benefit"...
January 30, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38337675/the-microbiota-gut-brain-axis-in-metabolic-syndrome-and-sleep-disorders-a-systematic-review
#36
REVIEW
Adriano Dos Santos, Serena Galiè
BACKGROUND: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut-brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host-microbial biomarkers in both sleep disturbances and MetS...
January 29, 2024: Nutrients
https://read.qxmd.com/read/38336953/the-potential-of-clostridium-butyricum-to-preserve-gut-health-and-to-mitigate-non-aids-comorbidities-in-people-living-with-hiv
#37
REVIEW
Qiyu Yang, Silvere D Zaongo, Lijiao Zhu, Jiangyu Yan, Jiadan Yang, Jing Ouyang
A dramatic reduction in mortality among people living with HIV (PLWH) has been achieved during the modern antiretroviral therapy (ART) era. However, ART does not restore gut barrier function even after long-term viral suppression, allowing microbial products to enter the systemic blood circulation and induce chronic immune activation. In PLWH, a chronic state of systemic inflammation exists and persists, which increases the risk of development of inflammation-associated non-AIDS comorbidities such as metabolic disorders, cardiovascular diseases, and cancer...
February 9, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38331656/evaluation-of-the-efficacy-of-probiotics-as-treatment-in-irritable-bowel-syndrome
#38
REVIEW
Cristina Ruiz-Sánchez, Blanca Escudero-López, María-Soledad Fernández-Pachón
Irritable bowel syndrome (IBS) is a gastrointestinal functional disorder mainly characterised by abdominal pain, bloating and altered bowel habits. Dysbiosis might seem to be involved in the pathogenesis of the disease. Probiotics represent a potential treatment, since these could favour the functional microbiota and improve symptoms. The aim was to review the effectiveness of the use of probiotics in IBS symptomatology, analysing the influence of duration and dose. 18 articles were included. At the individual level, Lactobacillus, Bifidobacterium and Bacillus could be useful in the treatment of symptoms...
February 7, 2024: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38329697/anti-diabetic-potentials-of%C3%A2-lactobacillus-strains-by-modulating-gut-microbiota-structure-and-%C3%AE-cells-regeneration-in-the-pancreatic-islets-of-alloxan-induced-diabetic-rats
#39
JOURNAL ARTICLE
Manoj Kumar, Tharmar Muthurayar, Sukumaran Karthika, Santhalingam Gayathri, Perumal Varalakshmi, Balasubramaniem Ashokkumar
Diabetes mellitus, a most common endocrine disorder of glucose metabolism, has become a global epidemic and poses a serious public health threat with an increased socio-economic burden. Escalating incidence of diabetes is correlated with changes in lifestyle and food habits that cause gut microbiome dysbiosis and β-cells damage, which can be addressed with dietary interventions containing probiotics. Hence, the search for probiotics of human origin with anti-diabetic, anti-AGE, and anti-ACE potentials has gained renewed interest for the effective management of diabetes and its associated complications...
February 8, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38322777/the-role-of-probiotics-and-synbiotics-on-treatment-of-gestational-diabetes-systematic-review-and-meta-analysis
#40
REVIEW
Arresta Vitasatria Suastika, I Gde Raka Widiana, Ni Nengah Dwi Fatmawati, Ketut Suastika, Ivana Beatrice Paulus, I Nengah Sujaya
OBJECTIVE: This review investigated the efficacy of probiotics and/or synbiotics in gestational diabetes mellitus treatment by targeting insulin resistance, lipid metabolism, and anti-inflammatory effects in an updated trial. DATA SOURCES: The literature review was performed using the key words "Probiotics," "Synbiotics," and "Gestational Diabetes" in several databases, including PubMed, ScienceDirect, and the Cochrane Central Register of Controlled Trials. STUDY ELIGIBILITY CRITERIA: Eligible publication was screened independently by 2 reviewers...
February 2024: AJOG global reports
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