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diabetes probiotic

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https://www.readbyqxmd.com/read/27884128/a-randomised-controlled-demonstration-trial-of-multifaceted-nutritional-intervention-and-or-probiotics-the-healthy-mums-and-babies-humba-trial
#1
Karaponi Okesene-Gafa, Minglan Li, Rennae S Taylor, John M D Thompson, Caroline A Crowther, Christopher J D McKinlay, Lesley M E McCowan
BACKGROUND: Maternal obesity is associated with adverse pregnancy outcomes and has lifelong negative implications for offspring health. The Institute of Medicine recommends limited gestational weight gain (GWG) in obese women for optimal maternal and infant outcomes. However, there is a gap regarding an effective and sustainable intervention strategy to achieve this goal. The aim of the healthy mums and babies (HUMBA) demonstration trial is to assess whether a multifaceted nutritional intervention and/or an oral probiotic treatment in obese pregnant women can reduce excessive GWG and optimise pregnancy outcomes...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27864537/effects-of-probiotic-supplementation-in-patients-with-type-2-diabetes-systematic-review-and-meta-analysis
#2
Vajihe Akbari, Fatemeh Hendijani
CONTEXT: The rising prevalence of type 2 diabetes requires increased efforts to find effective therapeutic agents for this complex condition. Following the recent observation that the gut microbiota is altered in diabetic patients, researchers investigated the effect of probiotics in patients with diabetes. OBJECTIVE: The aim of this systematic review was to assess the effects of probiotic consumption on glycemic control in diabetic patients. DATA SOURCES: PubMed, Scopus, Web of Science (formerly ISI Web of Knowledge), Cochrane Central Register of Controlled Trials, ClinicalTrials...
December 2016: Nutrition Reviews
https://www.readbyqxmd.com/read/27821438/akkermansia-muciniphila-improves-metabolic-profiles-by-reducing-inflammation-in-chow-diet-fed-mice
#3
Shaoqian Zhao, Wen Liu, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Rui-Xin Liu, Jie Hong
Abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of metabolic diseases, including obesity and type 2 diabetes (T2DM). The crosstalk between gut microbes and the host affects the inflammatory status and glucose tolerance of individuals, but the underlying mechanisms have not been elucidated completely. In this study, we treated the lean chow diet-fed mice with Akkermansia muciniphila, which is thought to be inversely correlated with inflammation status and body weight in rodents and humans, and we found that A...
November 7, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27812581/a-comparative-study-of-the-antidiabetic-effects-exerted-by-live-and-dead-multi-strain-probiotics-in-the-type-2-diabetes-model-of-mice
#4
Xiangfei Li, Qi Xu, Tian Jiang, Shuguang Fang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Type 2 diabetes is a metabolic syndrome characterized by insulin resistance and relative insulin deficiency. In this study, the anti-diabetic effects of live and dead multi-strain probiotics were explored and compared in a high-fat and streptozotocin-induced model of type 2 diabetes in mice. Either live or dead probiotics were daily administered orally to the mice over 10 weeks. Both live and dead multi-strain probiotics reduced HbA1C and leptin levels, improved glucose tolerance, and protected against the impairment of the pancreas, while the live probiotic showed a greater ability to reduce fasting and postprandial blood glucose levels...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27793221/cognitive-function-and-the-microbiome
#5
M G Gareau
There is increasing evidence that the composition of the resident bacteria within the gastrointestinal tract can influence the brain and behavior, particularly with respect to cognitive function. Cognitive function encompasses the life-long process of learning, both long- and short-term processes. Cognition was originally thought to be exclusively regulated by the central nervous system, with long-term potentiation and neurogenesis contributing to the creation and storage of memories, but now other systems, including, for example, the immune system and the intestinal microbiome may also be involved...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/27793203/the-use-of-probiotic-l-fermentum-me-3-containing-reg-activ-cholesterol-supplement-for-4%C3%A2-weeks-has-a-positive-influence-on-blood-lipoprotein-profiles-and-inflammatory-cytokines-an-open-label-preliminary-study
#6
Tiiu Kullisaar, Kersti Zilmer, Tiit Salum, Aune Rehema, Mihkel Zilmer
BACKGROUND: Cardiovascular diseases continue to be a challenge and burden to heath. The incidence of type 2 diabetes is increasing. Modifying the (common) risk factors of them is the key of longterm success. The aim of the study was to establish if the special composition of innovative food supplement Reg'Activ Cholesterol (RAC) has a positive influence to the human body cardiovascular-inflammatory and diabetic parameters. METHODS: Forty-five clinically asymptomatic participants consumed an RAC containing an antioxidative and antiatherogenic probiotic Lactobacillus fermentum ME-3 (LFME-3) for 4 weeks...
October 28, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27774001/the-significance-of-the-enteric-microbiome-on-the-development-of-childhood-disease-a-review-of-prebiotic-and-probiotic-therapies-in-disorders-of-childhood
#7
John Slattery, Derrick F MacFabe, Richard E Frye
Recent studies have highlighted the fact that the enteric microbiome, the trillions of microbes that inhabit the human digestive tract, has a significant effect on health and disease. Methods for manipulating the enteric microbiome, particularly through probiotics and microbial ecosystem transplantation, have undergone some study in clinical trials. We review some of the evidence for microbiome alteration in relation to childhood disease and discuss the clinical trials that have examined the manipulation of the microbiome in an effort to prevent or treat childhood disease with a primary focus on probiotics, prebiotics, and/or synbiotics (ie, probiotics + prebiotics)...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27764251/heterologous-expression-and-delivery-of-biologically-active-exendin-4-by-lactobacillus-paracasei-l14
#8
Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Deju Peng, Huiqin Ma, Shangwu Chen
Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, is an excellent therapeutic peptide drug for type 2 diabetes due to longer lasting biological activity compared to GLP-1. This study explored the feasibility of using probiotic Lactobacillus paracasei as an oral vector for recombinant exendin-4 peptide delivery, an alternative to costly chemical synthesis and inconvenient administration by injection. L. paracasei transformed with a plasmid encoding the exendin-4 gene (L. paracasei L14/pMG76e-exendin-4) with a constitutive promotor was successfully constructed and showed efficient secretion of exendin-4...
2016: PloS One
https://www.readbyqxmd.com/read/27758705/diabetes-management-by-probiotics-current-knowledge-and-future-perspectives
#9
Aziz Homayouni Rad, Farnaz Sahhaf, Tohid Hassanalilou, Hanieh-Sadat Ejtahed, Negar Motayagheni, Ahmad-Reza Soroush, Mina Javadi, Amir Mohammad Mortazavian, Leila Khalili
BACKGROUND: Diabetes mellitus, a condition of multifactorial origin, is related to the intestinal microbiota by numerous molecular mechanisms. Controlling the vast increase in the prevalence of diabetes needs a natural and safe solution. Probiotics, known as live microorganisms that exert health benefits to the host, have anti-diabetic property. OBJECTIVE: This review will highlight the current evidences in probiotic effectiveness and future prospects for exploring probiotic therapy in the prevention and control of diabetes...
October 14, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27757829/effect-of-probiotic-soy-milk-on-serum-levels-of-adiponectin-inflammatory-mediators-lipid-profile-and-fasting-blood-glucose-among-patients-with-type-ii-diabetes-mellitus
#10
Sadegh Feizollahzadeh, Reza Ghiasvand, Abbas Rezaei, Hossein Khanahmad, Akram Sadeghi, Mitra Hariri
Probiotic therapies are going to be an effective alternative therapeutic strategy in the treatment and management of diabetes. The mechanism behind the essential effects of probiotic therapies in diabetic patients was not fully understood. The objective of this study was to evaluate the effects of probiotic soy milk containing Lactobacillus planetarum A7 on inflammation, lipid profile, fasting blood glucose, and serum adiponectin among patients with type 2 diabetes mellitus. Forty patients with type 2 diabetes, at the age of 35-68 years old, were assigned to two groups in this randomized, double-blind, controlled clinical trial...
October 18, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27757592/improvement-in-glucose-tolerance-and-insulin-sensitivity-by-probiotic-strains-of-indian-gut-origin-in-high-fat-diet-fed-c57bl-6j-mice
#11
Mahalingam Balakumar, Durai Prabhu, Chandrakumar Sathishkumar, Paramasivam Prabu, Namita Rokana, Ramesh Kumar, Srividhya Raghavan, Avinash Soundarajan, Sunita Grover, Virender Kumar Batish, Viswanathan Mohan, Muthuswamy Balasubramanyam
PURPOSE: Diabetes and obesity are characterized by glucose intolerance, fat deposition, inflammation, and dyslipidemia. Recent reports postulated that distinct gut microbiota alterations were observed in obese/diabetic subjects and modulating gut microbiota beneficially through specific probiotics could be a potential therapeutic option for type 2 diabetes/obesity. Therefore, we attempted to study the efficacy of probiotics of Indian gut origin (Lactobacillus plantarum MTCC5690 and Lactobacillus fermentum MTCC5689) along with a positive control, Lactobacillus rhamnosus (LGG) on glucose/lipid homeostasis in high-fat-diet-induced diabetic animal model...
October 18, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27731809/hypoglycemic-and-hypolipidemic-effects-of-lactobacillus-fermentum-fruit-extracts-of-syzygium-cumini-and-momordica-charantia-on-diabetes-induced-mice
#12
Sehar Yousaf, Abid Hussain, Shafiqur Rehman, Muhammad Shahbaz Aslam, Zaigham Abbas
A lot of treatment strategies available for diabetes but its complications are still a medical problem around the globe. It demands to find out some alternative therapeutic measures. In order to investigate the anti-diabetic potential of probiotics and natural extracts, this study was designed. Accordingly, a local source of yogurt probiotic strain Lactobacillus fermentum was isolated and characterized that showed its probiotic properties. Besides this, natural extracts of plants fruits like java plum (Syzygium cumini) and bitter gourd (M...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27724923/effects-of-probiotics-vivomixx%C3%A2-in-obese-pregnant-women-and-their-newborn-study-protocol-for-a-randomized-controlled-trial
#13
Sofie Ingdam Halkjaer, Lisbeth Nilas, Emma Malchau Carlsen, Dina Cortes, Thórhallur Ingi Halldórsson, Sjúrdur Frodi Olsen, Anders Elm Pedersen, Karen Angeliki Krogfelt, Andreas Munk Petersen
BACKGROUND: Maternal obesity is associated with increased risks of adverse pregnancy-related complications and outcomes for both mothers and infants. Overweight and obese women have an increased risk of pregnancy-induced hypertension, preeclampsia and gestational diabetes mellitus (GDM). Infant Body Mass index (BMI) and the risk of obesity in adulthood are related to maternal gestational weight gain (GWG). Preventive lifestyle and dietary interventions are time-consuming and do not always reduce GWG or the risk of maternal pregnancy complications...
October 11, 2016: Trials
https://www.readbyqxmd.com/read/27713957/antidiabetic-type-2-effects-of-lactobacillus-g15-and-q14-in-rats-through-regulation-of-intestinal-permeability-and-microbiota
#14
Peijun Tian, Baolong Li, Canxia He, Wei Song, Aiju Hou, Sicong Tian, Xinyu Meng, Kaikai Li, Yujuan Shan
The antidiabetic effects of Lactobacillus. paracasei subsp. paracasei G15 and Lactobacillus. casei Q14 in high fat diet and streptozotocin-induced type 2 diabetic (T2D) rats were evaluated in this study. The strains were separated from Chinese traditional fermented dairy food. Administration of G15 and Q14 for 6 weeks significantly improved the glucose tolerance and reduced the HbA1c levels in T2D rats. The probiotic treatment reduced the intestinal mucosal permeability and improved the epithelial barrier function through modification of the gut microbiota, which in turn lowered circulating LPS and inflammation cytokines, including IL-1β and IL-8, and eventually alleviated the inflammatory status and islet β-cell dysfunction...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27631013/microflora-disturbance-during-progression-of-glucose-intolerance-and-effect-of-sitagliptin-an-animal-study
#15
Xinfeng Yan, Bo Feng, Peicheng Li, Zhaosheng Tang, Lin Wang
Background. Emerging evidences have shown a close interplay between obesity, diabetes, and intestinal flora disturbance. Dipeptidyl peptidase-4 inhibitor, exemplified by sitagliptin, is highly efficacious in treating type 2 diabetes (T2DM), yet little is known if sitagliptin exerts beneficial effects on microbiota associated with obesity and T2DM. We evaluated changes of gut microbiota following the induction of obesity and T2DM in a streptozotocin treated high fat/high carbohydrate fed (HF/HC-STZ) rat model and explored the effect of sitagliptin on gut microbiota for HF/HC-STZ rats...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27590729/effect-of-probiotics-and-synbiotics-on-blood-glucose-a-systematic-review-and-meta-analysis-of-controlled-trials
#16
Elham Nikbakht, Saman Khalesi, Indu Singh, Lauren Therese Williams, Nicholas P West, Natalie Colson
PURPOSE: High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels. METHODS: PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria...
September 3, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27573410/potential-efficacy-of-lactobacillus-casei-ibrc_m10711-on-expression-and-activity-of-insulin-degrading-enzyme-but-not-insulin-degradation
#17
Nadia Neyazi, Taiebeh Mohammadi Farsani, Zahra Nouri, Mohammad Hossein Ghahremani, Mohammad Reza Khorramizadeh, Roksana Tajerian, Elahe Motevaseli
Type 2 diabetes (T2D) is a condition with insufficient insulin production or in the setting of insulin resistance with many origins including intestinal microbiota-related molecular mechanism. Insulin-degrading enzyme (IDE) is responsible for insulin breakdown in various tissues and is known as a potential drug target for T2D. Here, we assessed the effects of cell-free supernatant (CFS) and UV-killed Lactobacillus casei IBRC_M10711 on IDE expression, IDE activity, and insulin degradation in Caco-2 cell line...
August 29, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27528065/increased-systolic-and-diastolic-blood-pressure-is-associated-with-altered-gut-microbiota-composition-and-butyrate-production-in-early-pregnancy
#18
Luisa F Gomez-Arango, Helen L Barrett, H David McIntyre, Leonie K Callaway, Mark Morrison, Marloes Dekker Nitert
The risk of developing pregnancy-induced hypertension and preeclampsia is higher in obese pregnant women. In obesity, the composition of the gut microbiota is altered. Obesity is also associated with low-grade inflammation. Metabolites from the gut microbiota may contribute to both hypertension and inflammation. The aim of this study is to investigate whether the composition of the gut microbiota in overweight and obese pregnant women is associated with blood pressure and levels of plasminogen activator inhibitor-1...
October 2016: Hypertension
https://www.readbyqxmd.com/read/27527163/coadjuvants-in-the-diabetic-complications-nutraceuticals-and-drugs-with-pleiotropic-effects
#19
REVIEW
Thiago Melo Costa Pereira, Fabio Silva Pimenta, Marcella Lima Porto, Marcelo Perim Baldo, Bianca Prandi Campagnaro, Agata Lages Gava, Silvana Santos Meyrelles, Elisardo Corral Vasquez
Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM...
August 5, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27429803/effects-of-a-multispecies-probiotic-mixture-on-glycemic-control-and-inflammatory-status-in-women-with-gestational-diabetes-a-randomized-controlled-clinical-trial
#20
Sadegh Jafarnejad, Sadaf Saremi, Farzan Jafarnejad, Arman Arab
Objective. This trial aims to examine the effects of a Probiotic Mixture (VSL#3) on glycemic status and inflammatory markers, in women with GDM. Materials and Methods. Over a period of 8 weeks, 82 women with gestational diabetes were randomly assigned to either an intervention group (n = 41) which were given VSL#3 capsule or to a control group which were given placebo capsule (n = 41). Fasting plasma glucose, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6, Interferon gamma, and interleukin-10 were measured before and after the intervention...
2016: Journal of Nutrition and Metabolism
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