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https://www.readbyqxmd.com/read/29432877/the-effects-of-vitamin-d-and-probiotic-co-supplementation-on-mental-health-parameters-and-metabolic-status-in-type-2-diabetic-patients-with-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#1
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: This study was carried out to evaluate the effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in diabetic people with coronary heart disease (CHD). METHODS: This randomized, double-blind, placebo-controlled trial was carried out among 60 diabetic people with CHD, aged 45-85 years old. Subjects were randomly allocated into two groups to receive either 50,000 IU vitamin D every 2 weeks plus 8 × 10 9 CFU/g probiotic of Lactocare Zisttakhmir Co (n = 30) or placebo (n = 30) for 12 weeks...
February 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29410236/gut-microbiota-and-probiotics-intervention-a-potential-therapeutic-target-for-management-of-cardiometabolic-disorders-and-chronic-kidney-disease
#2
REVIEW
Marinaldo Pacífico Cavalcanti Neto, Jailane de Souza Aquino, Larissa de Fátima Romão da Silva, Ruanniere de Oliveira Silva, Keyth Sulamitta de Lima Guimarães, Yohana de Oliveira, Evandro Leite de Souza, Marciane Magnani, Hubert Vidal, José Luiz de Brito Alves
The gut microbiota plays an important role in host metabolism and its dysregulation have been related to cardiometabolic disorders (CMD), such as type 2 diabetes mellitus (T2D), dyslipidemia and arterial hypertension, as well as to chronic kidney diseases (CKD). The implication of the gut microbiota on systemic disorders has been associated with changes in its composition (dysbiosis) as a result of the oxidative unbalance in the body. This alteration may be the result of the adoption of unhealthy lifestyle behavior, including lack of physical activity and fat- or sugar-rich diets, which are largely associated with increased incidence of CMD and CKD...
February 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29390450/effect-of-probiotics-on-lipid-profiles-and-blood-pressure-in-patients-with-type-2-diabetes-a-meta-analysis-of-rcts
#3
Jun He, Fan Zhang, Yan Han
BACKGROUND: This meta-analysis aimed to systematically evaluate the effects of probiotics on blood lipid and blood pressure among patients with type 2 diabetes mellitus (T2DM) based on the randomized controlled studies. METHODS: PubMed, Cochrane, Embase, Wanfang, China National Knowledge Infrastructure, and VIP database were searched by the index words to identify the qualified randomized control trial. The latest research was done in the January 2017. Mean difference (MD) along with 95% confidence interval (CI) was used to analyze the included outcomes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384067/interplay-of-gut-microbiota-probiotics-in-obesity-a-review
#4
Ramesh Pothuraju, Raj Kumar Sharma
Excess caloric intake and less energy expenditure (eg. physical inactivity) are associated with acquired metabolic disorders due to sedentary life style. Pharmacological treatments are less effective in preventing obesity. Type of diet influence the gut microbiome alteration and it is interrelated with obesity, insulin resistance and type 2 diabetes. Modified gut microbiota by the harmful bacterial components (eg: lipopolysaccharides) is linked with the metabolic endotoxemia (low-grade inflammation) which results in damage to the gut barrier function...
January 30, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29382113/association-of-dietary-patterns-with-components-of-metabolic-syndrome-and-inflammation-among-middle-aged-and-older-adults-with-metabolic-syndrome-in-taiwan
#5
Ahmad Syauqy, Chien-Yeh Hsu, Hsiao-Hsien Rau, Jane C-J Chao
This study examined the correlation of dietary patterns with components of metabolic syndrome (MetS) and inflammation among middle-aged and older adults with MetS in Taiwan. This cross-sectional study used data from the Mei Jau International Health Management Institution in Taiwan between 2004 and 2013. A total of 26,016 subjects aged 35 years and above were selected for analysis. MetS was defined according to the International Diabetes Federation. Three dietary patterns were identified by principal component analysis...
January 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29380310/pregnancy-and-lactation-a-window-of-opportunity-to-improve-individual-health
#6
Guadalupe L Rodríguez-González, Diana C Castro-Rodríguez, Elena Zambrano
Human and animal studies indicate that obesity during pregnancy adversely impacts both maternal health and offspring phenotype predisposing them to chronic diseases later in life including obesity, dyslipidemia, type 2 diabetes mellitus, and hypertension. Effective interventions during human pregnancy and/or lactation are needed to improve both maternal and offspring health. This review addresses the relationship between adverse perinatal insults and its negative impact on offspring development and presents some maternal intervention studies such as diet modification, probiotic consumption, or maternal exercise, to prevent or alleviate the negative outcomes in both the mother and her child...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29373989/effectiveness-and-safety-of-bifidobacteria-and-berberine-in-people-with-hyperglycemia-study-protocol-for-a-randomized-controlled-trial
#7
Jie Ming, Shaoyong Xu, Chun Liu, Xiangyang Liu, Aihua Jia, Qiuhe Ji
BACKGROUND: Berberine is one of the most important examples of a Chinese traditional medicine that has hypoglycemic effects but there have been no randomized controlled trials of the drug in a larger sample. In addition, the use of probiotic biotherapy to maintain an appropriate intestinal flora may represent an effective early intervention for hyperglycemia. Unfortunately, there has been a shortage of relevant research on this possibility at the population level. This study was designed to determine the hypoglycemic effect and safety of both bifidobacteria and berberine administration to newly diagnosed patients with pre-diabetes or diabetes mellitus...
January 26, 2018: Trials
https://www.readbyqxmd.com/read/29343517/early-infant-diet-and-islet-autoimmunity-in-the-teddy-study
#8
Ulla Uusitalo, Hye-Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Katherine Silvis, Åke Lernmark, Marian Rewers, William Hagopian, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey Krischer, Suvi M Virtanen, Jill M Norris
OBJECTIVE: To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes (T1D) in the U.S., Finland, Germany, and Sweden. This study included 7,563 children with at least 9 months of follow-up. Blood samples were collected every 3 months from birth to evaluate IA, defined as persistent, confirmed positive insulin autoantibodies (IAAs), glutamic acid decarboxylase, or insulinoma antigen-2...
January 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29336891/cupua%C3%A3-u-extract-reduces-nitrosative-stress-and-modulates-inflammatory-mediators-in-the-kidneys-of-experimental-diabetes
#9
Giovana R Punaro, Deyse Y Lima, Adelson M Rodrigues, Samuel Pugliero, Margaret G Mouro, Marcelo M Rogero, Elisa M S Higa
BACKGROUND & AIMS: We have previously reported an increased nitrosative stress in the kidneys of diabetic animals, which was reduced by an antioxidant probiotic. The present study evaluated whether the extract of cupuaçu (EC), an antioxidant compound rich in polyphenols and theograndins, when administered at a dose that can be reasonably obtained through daily consumption, could delay the onset of diabetic complications in the kidney. METHODS: Mouse immortalized mesangial cells (MiMC) were placed in medium normal glucose (NG) or high glucose (HG), with or without EC (500, 100, 50 or 10 μg/mL) during 24, 48 or 72 h for analysis of viability, proliferation, nitric oxide (NO) levels and reactive oxygen species or nitrogen (ROS/RNS)...
December 26, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29334718/-diet-and-nutrition-interventions-prevent-gestational-diabetes-mellitus
#10
Z Y Yang
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, with rising trend over the years. Dietary nutrient intake (protein, fat and fatty acids, carbohydrate, vitamin D, vitamin E, iron, zinc, selenium and inositol et al.), dietary pattern and probiotics may be related to GDM occurrence. Dietary factors are modifiable factors for preventing GDM. The study reviewed the roles of these dietary factors in preventing GDM. Results showed that plant-based dietary pattern may lower the risk of GDM and dietary pattern characterized with high animal protein, high fat and low carbohydrate may increase the risk of GDM...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29316320/human-microbiota-blood-group-antigens-and-disease
#11
REVIEW
D Rose Ewald, Susan C J Sumner
Far from being just "bugs in our guts," the microbiota interacts with the body in previously unimagined ways. Research into the genome and the microbiome has revealed that the human body and the microbiota have a long-established but only recently recognized symbiotic relationship; homeostatic balance between them regulates body function. That balance is fragile, easily disturbed, and plays a fundamental role in human health-our very survival depends on the healthy functioning of these microorganisms. Increasing rates of cardiovascular, autoimmune, and inflammatory diseases, as well as epidemics in obesity and diabetes in recent decades are believed to be explained, in part, by unintended effects on the microbiota from vaccinations, poor diets, environmental chemicals, indiscriminate antibiotic use, and "germophobia...
January 9, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29310610/pregnancy-outcomes-in-women-taking-probiotics-or-prebiotics-a-systematic-review-and-meta-analysis
#12
Alexander Jarde, Anne-Mary Lewis-Mikhael, Paul Moayyedi, Jennifer C Stearns, Stephen M Collins, Joseph Beyene, Sarah D McDonald
BACKGROUND: Probiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics. METHODS: We searched six electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Web of Science's Core collection and BIOSIS Preview) up to September 2016 and contacted authors for additional data...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29298969/-dietetary-recommendation-for-non-alcoholic-fatty-liver-disease
#13
REVIEW
Anna Jeznach-Steinhagen, Joanna Ostrowska, Aneta Czerwonogrodzka-Senczyna, Iwona Boniecka, Wioletta Gronostajska
Non-alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the developed world. Nowadays, in the adult population of Europe it is estimated at 14% to 21%. Its most important risk factors are obesity and metabolic syndrome. Introducing lifestyle changes such as: dietary intervention and increased physical activity are the first-line treatment and are intended to support not only NAFLD but also associated diseases such as obesity, insulin resistance, diabetes and dyslipidemia...
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29286343/microbial-regulation-of-glucose-metabolism-and-insulin-resistance
#14
REVIEW
Silke Crommen, Marie-Christine Simon
Type 2 diabetes is a combined disease, resulting from a hyperglycemia and peripheral and hepatic insulin resistance. Recent data suggest that the gut microbiota is involved in diabetes development, altering metabolic processes including glucose and fatty acid metabolism. Thus, type 2 diabetes patients show a microbial dysbiosis, with reduced butyrate-producing bacteria and elevated potential pathogens compared to metabolically healthy individuals. Furthermore, probiotics are a known tool to modulate the microbiota, having a therapeutic potential...
December 29, 2017: Genes
https://www.readbyqxmd.com/read/29222051/long-term-fermented-soybean-paste-improves-metabolic-parameters-associated-with-non-alcoholic-fatty-liver-disease-and-insulin-resistance-in-high-fat-diet-induced-obese-mice
#15
Min-Seok Kim, Bobae Kim, Haryung Park, Yosep Ji, Wilhelm Holzapfel, Do-Young Kim, Chang-Kee Hyun
Recently, Korean traditional fermented soybean paste, called Doenjang, has attracted attention for its protective effect against diet-related chronic diseases such as obesity and type 2 diabetes. Long-term fermented soybean pastes (LFSPs) are made by fermentation with naturally-occurring microorganisms for several months, whereas short-term fermented soybean pastes (SFSPs) are produced by shorter-time fermentation inoculated with a starter culture. Here, we demonstrate that administration of LFSP, but not SFSP, protects high-fat diet (HFD)-fed obese mice against non-alcohol fatty liver disease (NAFLD) and insulin resistance...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29221120/gut-microbial-profile-analysis-by-miseq-sequencing-of-pancreatic-carcinoma-patients-in-china
#16
Zhigang Ren, Jianwen Jiang, Haiyang Xie, Ang Li, Haifeng Lu, Shaoyan Xu, Lin Zhou, Hua Zhang, Guangying Cui, Xinhua Chen, Yuanxing Liu, Liming Wu, Nan Qin, Ranran Sun, Wei Wang, Lanjuan Li, Weilin Wang, Shusen Zheng
Pancreatic carcinoma (PC) is a lethal cancer. Gut microbiota is associated with some risk factors of PC, e.g. obesity and types II diabetes. However, the specific gut microbial profile in clinical PC in China has never been reported. This prospective study collected 85 PC and 57 matched healthy controls (HC) to analyze microbial characteristics by MiSeq sequencing. The results showed that gut microbial diversity was decreased in PC with an unique microbial profile, which partly attributed to its decrease of alpha diversity...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206649/the-importance-of-the-microbiome-in-pediatrics-and-pediatric-infectious-diseases
#17
Thaidra Gaufin, Nicole H Tobin, Grace M Aldrovandi
PURPOSE OF REVIEW: Emerging research on the pediatric microbiome implicates the importance of the microbiome on the development of the immune system, nervous system, and growth. Changes to the microbiome during infancy are associated with the development of chronic illnesses such as asthma and inflammatory bowel disease. Additionally, the microbiome provides protection against certain pathogens, affects vaccine responses, and alters drug metabolism. This review highlights what is known about the microbiome, the establishment of a healthy microbiome and the significance that changes to the microbiome composition have on growth and health of children and adolescents...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29193662/the-effects-of-probiotic-administration-on-wound-healing-and-metabolic-status-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#18
Sima Mohseni, Masomeh Bayani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Mohammad Ali Bayani, Parvaneh Jafari, Zatollah Asemi
BACKGROUND: This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU). METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85 years old) with grade 3 DFU. Individuals were randomly divided into two groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks. RESULTS: After the 12-week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (-1...
November 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29179878/oxidative-stress-and-diabetes-glucose-response-in-the-crossfire
#19
EDITORIAL
Emma Louise Walton
In this issue of the Biomedical Journal, we discuss the emerging role of reactive oxygen species (ROS) in the development of insulin resistance and ultimately type 2 diabetes. We focus also on research investigating the outcome of in vitro fertilization after laproscopic surgery for ovarian endometriosis. Finally, we learn the results of a study on the hunt for new probiotic bacteria.
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29171288/featured-article-structure-moderation-of-gut-microbiota-in-liraglutide-treated-diabetic-male-rats
#20
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
The change of gut microbiome is associated with a serious of metabolic disorders, such as diabetes. As a glucagon-like peptide 1 analogue, liraglutide is a potent antidiabetic drug in clinical practice. However, the effect of liraglutide on the community of gut microbiota is still unknown. We aimed to determine the influence of liraglutide on fecal microbiota in diabetic male rats. Five-week-old male Sprague-Dawley rats were fed with a control diet or a high-fat diet for four weeks. By injecting streptozotocin, the diabetic rat model was performed...
January 2018: Experimental Biology and Medicine
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