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https://www.readbyqxmd.com/read/28818268/-metformin-resistant-folic-acid-producing-probiotics-or-folic-acid-against-metformin-s-adverse-effects-like-diarrhea
#1
Abdullah Olgun
Metformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28818264/the-potential-management-of-oral-candidiasis-using-anti-biofilm-therapies
#2
Warren Chanda, Thomson P Joseph, Wendong Wang, Arshad A Padhiar, Mintao Zhong
Candida albicans is a minor component of the oral microbiota and an opportunistic pathogen that takes advantage of the immunocompromised host and causes oral mucositis and oral candidiasis. This organism is able to undergo phenotypic modification from a yeast to hyphae growth phase, one of the key arsenals for immune cell evasion, tissue invasion and biofilm formation. The latter property coupled with overgrowth and immune compromising factors such as HIV/AIDS, cancer treatments, organ transplantation, diabetes, corticosteroid use, dentures, and broad-spectrum antibiotic use have modified the fungus from a normal component of the microflora to a foe of an oral cavity and resulting in reduced sensitivity towards commonly utilised antifungal agents...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28782784/lactobacillus-casei-ccfm419-attenuates-type-2-diabetes-via-a-gut-microbiota-dependent-mechanism
#3
Gang Wang, Xiangfei Li, Jianxin Zhao, Hao Zhang, Wei Chen
Probiotics, as dietary supplements, transmit their major effects through the regulation of gut microbiota. According to a previous study, one possible mechanism of Lactobacillus casei CCFM419 protection against diabetes may involve gut flora. To test this hypothesis, high fat and streptozotocin-induced C57BL/6J mice were fed L. casei CCFM419 at 10(8), 10(9), and 10(10) colony forming units (CFU). Compared to untreated mice, 10(9) CFU of L. casei CCFM419 attenuated several symptoms of diabetes, including fasting blood glucose, postprandial blood glucose, glucose intolerance, and insulin resistance...
August 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28770903/probiotic-yogurt-effect-on-macronutrients-ingredients-blood-glucose-and-lipid-profile-in-type-2-diabetes
#4
Zahra Tazakori, Maryam Zare, Mohammad Asghari Jafarabadi
No abstract text is available yet for this article.
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28765642/anti-diabetic-effects-of-clostridium-butyricum-cgmcc0313-1-through-promoting-the-growth-of-gut-butyrate-producing-bacteria-in-type-2-diabetic-mice
#5
Lingling Jia, Dongyao Li, Ninghan Feng, Muhammad Shamoon, Zhenghua Sun, Lei Ding, Hao Zhang, Wei Chen, Jia Sun, Yong Q Chen
Patients with type 2 diabetes (T2D) have decreased butyrate-producing bacteria. We hypothesized that supplementation with butyrate-producing bacteria may exert beneficial effects on T2D. The current study investigated the effects of well-characterized butyrate-producing bacteria Clostridium butyricum CGMCC0313.1 (CB0313.1) on hyperglycemia and associated metabolic dysfunction in two diabetic mouse models. CB0313.1 was administered daily by oral gavage to leptin (db/db) mice for 5 weeks starting from 3 weeks of age, and to HF diabetic mice induced by high fat diet (HFD) plus streptozotocin (STZ) in C57BL/6J mice for 13 weeks starting from 4 weeks of age...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28736228/dbz-is-a-putative-ppar%C3%AE-agonist-that-prevents-high-fat-diet-induced-obesity-insulin-resistance-and-gut-dysbiosis
#6
Pengfei Xu, Fan Hong, Jialin Wang, Jing Wang, Xia Zhao, Sheng Wang, Tingting Xue, Jingwei Xu, Xiaohui Zheng, Yonggong Zhai
BACKGROUND: The nuclear receptor PPARγ is an effective pharmacological target for some types of metabolic syndrome, including obesity, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. However, the current PPARγ-targeting thiazolidinedione drugs have undesirable side effects. Danshensu Bingpian Zhi (DBZ), also known as tanshinol borneol ester derived from Salvia miltiorrhiza, is a synthetic derivative of natural compounds used in traditional Chinese medicine for its anti-inflammatory activity...
July 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28720399/prenatal-and-postnatal-administration-of-prebiotics-and-probiotics
#7
REVIEW
Kristin Sohn, Mark A Underwood
Colonization of the neonatal gut by beneficial bacteria is important for the establishment and maintenance of the mucosal barrier, thus protecting the neonate from enteric pathogens and local and systemic inflammation. The neonatal microbiome is influenced by infant diet, environment, and the maternal microbiome. Dysbiosis in pregnancy increases the risk of pre-eclampsia, diabetes, infection, preterm labor, and later childhood atopy. Dysbiosis of the neonatal gut plays an important role in colic in the term infant, in the disease processes which plague preterm infants, including necrotizing enterocolitis and sepsis, and in the long-term outcomes of neonates...
July 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28691473/oral-probiotics-in-the-management-of-gingivitis-in-diabetic-patients-a-double-blinded-randomized-controlled-study
#8
S Sabatini, D Lauritano, V Candotto, F J Silvestre, G M Nardi
Diabetic patients are more prone to develop infections such as periodontal diseases. Bacteriotherapy with the concept of using good bacterial strains to replace the pathogenic ones emerged as a fascinating field due to the increasing incidence of antibiotic resistance. The aim of this study was to evaluate if a particular combination of probiotics (Lactobacillus Reuteri DSM 17938 and Lactobaciullus Reuteri ATCC PTA 5289) is useful in treating gingivitis in diabetic patients. Eighty adult patients with diagnosis of controlled diabetes type II and gingivitis were enrolled for this study and randomized in two groups...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28678744/gut-microbial-profile-analysis-by-miseq-sequencing-of-pancreatic-carcinoma-patients-in-china
#9
Zhigang Ren, Jianwen Jiang, Haiyang Xie, Ang Li, Haifeng Lu, Shaoyan Xu, Lin Zhou, Hua Zhang, Guangying Cui, Xinhua Chen, Yuanxing Liu, Liming Wu, Nan Qin, Ranran Sun, Wei Wang, Lanjuan Li, Weilin Wang, Shusen Zheng
Pancreatic carcinoma (PC) is a lethal cancer. Gut microbiota is associated with some risk factors of PC, e.g. obesity and types II diabetes. However, the specific gut microbial profile in clinical PC in China has never been reported. This prospective study collected 85 PC and 57 matched healthy controls (HC) to analyze microbial characteristics by MiSeq sequencing. The results showed that gut microbial diversity was decreased in PC with an unique microbial profile, which partly attributed to its decrease of alpha diversity...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28659913/lactobacillus-johnsonii-n6-2-modulates-the-host-immune-responses-a-double-blind-randomized-trial-in-healthy-adults
#10
Guillermo E Marcial, Amanda L Ford, Michael J Haller, Salvador A Gezan, Natalie A Harrison, Dan Cai, Julie L Meyer, Daniel J Perry, Mark A Atkinson, Clive H Wasserfall, Timothy Garrett, Claudio F Gonzalez, Todd M Brusko, Wendy J Dahl, Graciela L Lorca
Lactobacillus johnsonii N6.2 mitigates the onset of type 1 diabetes (T1D) in biobreeding diabetes-prone rats, in part, through changes in kynurenine:tryptophan (K:T) ratios. The goal of this pilot study was to determine the safety, tolerance, and general immunological response of L. johnsonii N6.2 in healthy subjects. A double-blind, randomized clinical trial in 42 healthy individuals with no known risk factors for T1D was undertaken to evaluate subject responses to the consumption of L. johnsonii N6.2. Participants received 1 capsule/day containing 10(8) colony-forming units of L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28659729/some-current-applications-limitations-and-future-perspectives-of-lactic-acid-bacteria-as-probiotics
#11
REVIEW
Smith Etareri Evivie, Gui-Cheng Huo, John Oamen Igene, Xin Bian
Several mechanism and non-mechanism-based studies supporting the claim that lactic acid bacteria (LAB) strains confer health benefits and play immune-modulatory roles were examined in this review. Probiotic applications of LAB on global burdens such as obesity and type-2 diabetes were discussed as well as the use of yoghurt and ice cream as important vehicles to convey several beneficial LAB strains. Probiotic and symbiotic dairy products may be used in the nearest future to treat a variety of health disorders...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28646072/genetic-and-environmental-interactions-modify-the-risk-of-diabetes-related-autoimmunity-by-6-years-of-age-the-teddy-study
#12
Jeffrey P Krischer, Kristian F Lynch, Åke Lernmark, William A Hagopian, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Beena Akolkar
OBJECTIVE: We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes. RESEARCH DESIGN AND METHODS: Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. SNPs came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years. RESULTS: Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children)...
June 23, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28643167/microbiome-probiotics-and-neurodegenerative-diseases-deciphering-the-gut-brain-axis
#13
REVIEW
Susan Westfall, Nikita Lomis, Imen Kahouli, Si Yuan Dia, Surya Pratap Singh, Satya Prakash
The gut microbiota is essential to health and has recently become a target for live bacterial cell biotherapies for various chronic diseases including metabolic syndrome, diabetes, obesity and neurodegenerative disease. Probiotic biotherapies are known to create a healthy gut environment by balancing bacterial populations and promoting their favorable metabolic action. The microbiota and its respective metabolites communicate to the host through a series of biochemical and functional links thereby affecting host homeostasis and health...
June 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28638006/effect-of-probiotics-on-glucose-and-lipid-metabolism-in-type-2-diabetes-mellitus-a-meta-analysis-of-12-randomized-controlled-trials
#14
Kecheng Yao, Linghai Zeng, Qian He, Wei Wang, Jiao Lei, Xiulan Zou
BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level...
June 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28615384/yogurt-and-diabetes-overview-of-recent-observational-studies
#15
REVIEW
Jordi Salas-Salvadó, Marta Guasch-Ferré, Andrés Díaz-López, Nancy Babio
The effects of dairy consumption on the prevention of type 2 diabetes remain controversial and depend on the dairy subtype. Yogurt intake has received special attention because its association with health benefits is more consistent than that of other types of dairy products. In the present article, we review those observational studies that evaluated the association between yogurt consumption and type 2 diabetes. We also discuss the possible mechanisms involved in these associations. We found that 13 prospective studies evaluated the association between yogurt intake and type 2 diabetes, most of which showed an inverse association between the frequency of yogurt consumption and the risk of diabetes...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28615382/factors-influencing-the-gut-microbiota-inflammation-and-type-2-diabetes
#16
REVIEW
Li Wen, Andrew Duffy
The gut microbiota is a complex community of bacteria residing in the intestine. Animal models have demonstrated that several factors contribute to and can significantly alter the composition of the gut microbiota, including genetics; the mode of delivery at birth; the method of infant feeding; the use of medications, especially antibiotics; and the diet. There may exist a gut microbiota signature that promotes intestinal inflammation and subsequent systemic low-grade inflammation, which in turn promotes the development of type 2 diabetes...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28608654/comparative-evaluation-of-probiotics-effects-on-plasma-glucose-lipid-and-insulin-levels-in-streptozotocin-induced-diabetic-rats
#17
Faeghe Memarrast, Soudeh Ghafouri-Fard, Sedighe Kolivand, Saeedeh Jafary-Nodooshan, Nadia Neyazi, Esmaeil Sadroddiny, Elahe Motevaseli
BACKGROUND: Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both of them. Daily consumption of probiotics, particularly Lactobacilli has been proposed as a new strategy for prevention or control of diabetes. METHODS: In the current study, the effects of various probiotics including Lactobacillus reuteri (L.reuteri), Lactobacillus crispatus (L.crispatus) and Bacillus subtilis on the levels of blood glucose, lipid and insulin as well as HbA1c were investigated in rat models of streptozotocin (STZ)-induced diabetes and compared with metformin...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28599375/multiple-effects-of-probiotics-on-different-types-of-diabetes-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#18
REVIEW
Xia Wang, Qi-Fang Juan, Yu-Wei He, Li Zhuang, Yuan-Yuan Fang, Yong-Hong Wang
BACKGROUND: A systematic review and meta-analysis was designed to evaluate the effect of probiotics on diabetes and its associated risk factors. METHODS: We systematically searched the Cochrane Library, PubMed, EMBASE and Web of Science to June 2016. We also hand-searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Our primary outcome variables included glucose, glycated hemoglobin (HbA1c) and insulin...
May 24, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28589103/effect-of-symbiotic-supplementation-on-glycemic-control-lipid-profiles-and-microalbuminuria-in-patients-with-non-obese-type-2-diabetes-a-randomized-double-blind-clinical-trial
#19
Zarin Sadat Ebrahimi, Ensieh Nasli-Esfahani, Azadeh Nadjarzade, Hassan Mozaffari-Khosravi
BACKGROUND: The prevalent raise of type 2 diabetes (T2D) around the globe, are creating higher risk for cardiovascular diseases (CVDs) and increasing strain on each country's health care budget in the world. Microalbuminuria has appeared as a key parameter in diabetic patients. Microalbuminuria is also related to increased cardiovascular morbidity in people who are non-obese diabetic. Some studies have suggested that consumption of symbiotic foods might help improve the metabolic profile, inflammatory factors and biomarkers of oxidative stress...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28579313/the-impact-of-probiotic-soy-milk-consumption-on-oxidative-stress-among-type-2-diabetic-kidney-disease-patients-a-randomized-controlled-clinical-trial
#20
Maryam Miraghajani, Nafiseh Zaghian, Maryam Mirlohi, Awat Feizi, Reza Ghiasvand
OBJECTIVE: Diabetic kidney disease (DKD) is one the most important complications of diabetes leading to end-stage renal disease. This study aimed to determine the effects of probiotic soy milk consumption on oxidative stress biomarkers in type 2 DKD patients. METHODS: Forty-eight patients were randomly assigned to consume a diet containing 200 mL/day probiotic soy milk in the intervention group or soy milk in the control condition. As determinants of oxidative stress, malondialdehyde, 8-iso-prostaglandin F2α, oxidized glutathione, total antioxidant capacity, reduced glutathione (GSH), glutathione peroxidase, and glutathione reductase were measured after 8 weeks of intervention according to the standard protocol...
May 31, 2017: Journal of Renal Nutrition
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