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Mild Hypothermia treatment

Yauk K Lee, Alex Penn, Mahesh Patel, Rajul Pandit, Dongli Song, Bo Yoon Ha
To determine the optimal time window for MR imaging with quantitative ADC measurement in neonatal HIE after hypothermia treatment, a retrospective review was performed on consecutive hypothermia-treated term neonates with HIE, with an initial and follow-up MR imaging within the first two weeks of life. Three neuroradiologists categorized each set of MR imaging as normal, mild, moderate or severe HIE based on a consensus review of the serial imaging. The lowest ADC values from the white matter, corpus callosum, and basal ganglia/thalamus were measured...
November 23, 2016: Neuroradiology Journal
Byoung-Joon Oh, Yong-Gyun Im, Eunjung Park, Young-Gi Min, Sang-Cheon Choi
OBJECTIVE: The effect of induced hypothermia on severe acute carbon monoxide (CO) poisoning remains to be addressed further. We investigated the effect of induced hypothermia on severe acute CO poisoning. METHODS: Retrospective chart review was conducted for patients who diagnosed as severe acute CO poisoning in emergency department and underwent induced hypothermia from May 2013 to May 2014. Hospital courses with critical medication and major laboratory results were investigated through the chart review...
June 2016: Clinical and Experimental Emergency Medicine
Yan Wang, Jian Song, Yuhong Liu, Yaqiang Li, Zhengxin Liu
BACKGROUND The purpose of this study was to determine the effect of mild hypothermia therapy on gastric mucosa after cardiopulmonary resuscitation (CPR) and the underlying mechanism. MATERIAL AND METHODS Ventricular fibrillation was induced in pigs. After CPR, the surviving pigs were divided into mild hypothermia-treated and control groups. The changes in vital signs and hemodynamic parameters were monitored before cardiac arrest and at intervals of 0.5, 1, 2, 4, 6, 12, and 24 h after restoration of spontaneous circulation...
October 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Andreas Zierer, Ali El-Sayed Ahmad, Nestoras Papadopoulos, Faisal Detho, Petar Risteski, Anton Moritz, Anno Diegeler, Paul P Urbanski
OBJECTIVE: Surgery for acute type A aortic dissection remains a surgical challenge because of prolonged operative times, bleeding complications, and a considerable risk of neurological morbidity and mortality. The following study investigates the clinical results after surgical treatment for acute type A aortic dissection using selective antegrade cerebral perfusion and moderate-to-mild systemic hypothermia (≥28 °C). METHODS: Between January 2000 and January 2015, 453 consecutive patients underwent surgical treatment for acute type A aortic dissection at two aortic referral centres in Germany...
October 2, 2016: European Journal of Cardio-thoracic Surgery
Hongtao Sun, Maohua Zheng, Yanmin Wang, Yunfeng Diao, Wanyong Zhao, Zhengjun Wei
OBJECTIVE: The aim of this study was to investigate the clinical significance and changes of brain tissue partial pressure of oxygen (PbtO2) in the course of mild hypothermia treatment (MHT) for treating severe traumatic brain injury (sTBI). METHODS: There were 68 cases with sTBI undergoing MHT. PbtO2, intracranial pressure (ICP), jugular venous oxygen saturation (SjvO2), and cerebral perfusion pressure (CPP) were continuously monitored, and clinical outcomes were evaluated using the Glasgow Outcome Scale score...
2016: Neuropsychiatric Disease and Treatment
Christopher E D Saunderson, Amrit Chowdhary, Richard A Brogan, Phillip D Batin, Christopher P Gale
Mild hypothermia has been shown to improve neurological outcome and reduce mortality following out of hospital cardiac arrest. In animal models the application of hypothermia with induced coronary occlusion has demonstrated a reduction in infarct size. Consequently, hypothermia has been proposed as a treatment, in addition to Primary Percutaneous Coronary Intervention (PPCI) for ST segment elevation myocardial infarction (STEMI). However, there is incomplete understanding of the mechanism and magnitude of the protective effect of hypothermia on the myocardium, and limited outcome data...
November 15, 2016: International Journal of Cardiology
Chong Chen, Tie-Zhu Ma, Li-Na Wang, Jing-Jing Wang, Yue Tu, Ming-Liang Zhao, Sai Zhang, Hong-Tao Sun, Xiao-Hong Li
Although previous research has demonstrated that traumatic brain injury (TBI) accelerates the proliferation of neural stem cells in dentate gyrus of the hippocampus, most of these newborn cells undergo apoptosis in a traumatic microenvironment. Thus, promoting the long-term survival of newborn cells during neurogenesis is a compelling goal for the treatment of TBI. In this study, we investigated whether mild hypothermia (MHT) therapy, which mitigates the multiple secondary injury cascades of TBI, enhances the survival of newborn cells...
October 29, 2016: Neuroscience
Yue Tu, Xiao-Mei Miao, Tai-Long Yi, Xu-Yi Chen, Hong-Tao Sun, Shi-Xiang Cheng, Sai Zhang
Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and blood-brain barrier dysfunction...
June 2016: Neural Regeneration Research
Hong-Tao Sun, Maohua Zheng, Yanmin Wang, Yunfeng Diao, Wanyong Zhao, Zhengjun Wei
The aim of the study was to evaluate the clinical value of multiple brain parameters on monitoring intracranial pressure (ICP) procedures in the therapy of severe traumatic brain injury (sTBI) utilizing mild hypothermia treatment (MHT) alone or a combination strategy with other therapeutic techniques. A total of 62 patients with sTBI (Glasgow Coma Scale score <8) were treated using mild hypothermia alone or mild hypothermia combined with conventional ICP procedures such as dehydration using mannitol, hyperventilation, and decompressive craniectomy...
2016: Neuropsychiatric Disease and Treatment
J C Zhang, W Lu, X M Xie, H Pan, Z Q Wu, G T Yang
Although therapeutic hypothermia is an effective treatment for post-resuscitation brain injury after cardiac arrest (CA), the underlying mechanism remains unclear. Vacuolar H(+)-ATPase (V-ATPase) plays a key role in cellular adaption to a hypoxic environment. This study sought to evaluate the effect of mild hypothermia on V-ATPase and its involvement in neuroprotection after CA. Male Sprague-Dawley rats were subjected to a 6-min CA, resuscitated successfully, and then assigned to either the normothermia (NT) group or the hypothermia (HT) group...
2016: Genetics and Molecular Research: GMR
Kaiyin Liu, Hajra Khan, Xiaokun Geng, Jun Zhang, Yuchuan Ding
Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of systems including cannabinoid, opioid, transient receptor potential vanilloid 1 (TRPV1), neurotensin, thyroxine derivatives, dopamine, gas, and adenosine derivatives...
June 2016: Neurological Research
Jin Hwan Lee, Ling Wei, Xiaohuan Gu, Soonmi Won, Zheng Zachory Wei, Thomas A Dix, Shan Ping Yu
BACKGROUND AND PURPOSE: Therapeutic hypothermia is a promising strategy for treatment of acute stroke. Clinical translation of therapeutic hypothermia, however, has been hindered because of the lack of efficiency and adverse effects. We sought to enhance the clinical potential of therapeutic hypothermia by combining physical cooling (PC) with pharmacologically induced hypothermia after ischemic stroke. METHODS: Wistar rats were subjected to 90-minute middle cerebral artery occlusion by insertion of an intraluminal filament...
July 2016: Stroke; a Journal of Cerebral Circulation
Matthias C Dufner, Florian Andre, Jan Stiepak, Thomas Zelniker, Emmanuel Chorianopoulos, Michael Preusch, Hugo A Katus, Florian Leuschner
BACKGROUND: Patients admitted to the hospital after primarily successful cardiopulmonary resuscitation (CPR) are at a very high risk for neurologic deficits and death. Targeted temperature management (TTM) for mild therapeutic hypothermia has been shown to improve survival compared to standard treatment. Acute cardiovascular events, such as myocardial infarction (MI), are a major cause for cardiac arrest (CA) in patients who undergo CPR. Recent findings have demonstrated the importance and impact of the leukocyte response following acute MI...
June 2016: Cardiovascular Diagnosis and Therapy
Michael A Hawk, Glenn D Ritchie, Kim A Henderson, Katherine A B Knostman, Brian M Roche, Zhenxu J Ma, Claire M Matthews, Carol L Sabourin, Edward J Wakayama, Patrick J Sabourin
The Food and Drug Administration Animal Rule requires evaluation of cardiovascular and central nervous system (CNS) effects of new therapeutics. To characterize an adult and juvenile mouse model, neurobehavioral and cardiovascular effects and pathology of a single sublethal but toxic, 8 mg/kg, oral dose of potassium cyanide (KCN) for up to 41 days postdosing were investigated. This study describes the short- and long-term sensory, motor, cognitive, and behavioral changes associated with oral dosing of a sublethal but toxic dose of KCN utilizing functional observation battery and Tier II CNS testing in adult and juvenile mice of both sexes...
September 2016: International Journal of Toxicology
Filippo Benassi, Enrico Giuliani, Davide Corticelli, Roberto Parravicni
UNLABELLED:  Abstract  PURPOSE: several therapeutic options are used in emergency situations, when heart and/or lung functions acutely fail. Because of the poor results of conventional treatments, the use of an extra-corporeal life support (ECLS) systems able to completely assume the heart and lung functions in emergency situations is becoming a viable alternative. We have developed a unique ECLS system for patients needing extended respiratory and/or circulatory support and controlled hypothermia...
2016: Acta Bio-medica: Atenei Parmensis
Alexandre Mendibil, Daniel Jost, Aurélien Thiry, Delphine Garcia, Julie Trichereau, Benoit Frattini, Pascal Dang-Minh, Olga Maurin, Sylvie Margerin, Laurent Domanski, Jean-Pierre Tourtier
OBJECTIVES: In case of mild therapeutic hypothermia after an out-of-hospital cardiac arrest, several techniques could limit the cold fluid rewarming during its perfusion. We aimed to evaluate cold fluid temperature evolution and to identify the factors responsible for rewarming in order to suggest a prediction model of temperature evolution. EQUIPMENT AND METHODS: This was a laboratory experimental study. We measured temperature at the end of the infusion line tubes (ILT)...
May 6, 2016: Anaesthesia, Critical Care & Pain Medicine
Ireneusz Haponiuk, Maciej Chojnicki, Konrad Paczkowski, Wojciech Kosiak, Radosław Jaworski, Mariusz Steffens, Aneta Szofer-Sendrowska, Katarzyna Gierat-Haponiuk, Marek Tomaszewski
The presence of a pathologic mass in the right ventricle (RV) may lead to hemodynamic consequences and to a life-threatening incident of pulmonary embolism. The diagnosis of an unstable thrombus in the right heart chamber usually necessitates intensive treatment to dissolve or remove the pathology. We present a report of an unusual complication of severe ketoacidosis: thrombus in the right ventricle, removed from the tricuspid valve (TV) apparatus. A four-year-old boy was diagnosed with diabetes mellitus (DM) type I de novo...
2016: Heart Surgery Forum
Emre Aruğaslan, Mehmet Karaca, Kazım Serhan Özcan, Ahmet Zengin, Mustafa Adem Tatlısu, Emrah Bozbeyoğlu, Seçkin Satılmış, Özlem Yıldırımtürk, İbrahim Yekeler, Zekeriya Nurkalem
OBJECTIVE: Therapeutic hypothermia improves neurologic prognosis after cardiac arrest. The aim of this study was to report clinical experience with intravascular method of cooling in patients with cardiac arrest resulting from ST-segment elevation myocardial infarction (STEMI). METHODS: Thirteen patients (11 male, 2 famele; mean age was 39.6±9.4 years) who had undergone mild therapeutic hypothermia (MTH) by intravascular cooling after cardiac arrest due to STEMI were included...
March 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Jarosław Szczygieł, Justyna Mazurek, Andrzej Świątkowski, Katarzyna Broniec-Siekaniec, Marta Czapnik, Beata Średniawa, Józef Opara, Krystian Oleszczyk
The use of mild therapeutic hypothermia (MTH) in adult patients remaining in a coma following cardiac arrest, regardless of its mechanism and location, is recommended by the European Resuscitation Council. The study presents a case of a 52-year-old man in whom MTH was used following successfully resuscitated out-of- hospital sudden cardiac arrest caused by ventricular fibrillation. On the basis of this case it was indicated that the use of low temperatures may be an effective method of neuroprotective treatment since such activity is compatible with later observed great possibility of the brain to compensate and with the maintenance of brain plasticity which is crucial for neuropsychological rehabilitation...
March 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Dávid Pilecky, Gábor Szudi, Enikő Kovács, Zsigmond Jenei, László Gellér, Krisztina Heltai, Levente Molnár, György Bárczi, Dávid Becker, Béla Merkely, Endre Zima
In the last fifteen years mild therapeutic hypothermia became an accepted and widespread therapeutic method in the treatment of successfully resuscitated patients due to sudden cardiac death. Based on the available evidence therapeutic hypothermia is part of the resuscitation guidelines, however, many aspects of its therapeutic use are based on empirical facts. In particular, the subjects of intense debate are the ideal target temperature and the benefit of hypothermia in patients found with non-shockable rhythm...
April 17, 2016: Orvosi Hetilap
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