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Y C Nie, L J Yu, H Guan, Y Zhao, H B Rong, B W Jiang, T Zhang
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields. In forensic science, because of the relative stable, heritable, abundant, and age-related characteristics, DNA methylation is considered to be a useful complement to the classic genetic markers for age-prediction, tissue-identification, and monozygotic twins' discrimination. Various methods for DNA methylation detection have been validated based on methylation sensitive restriction endonuclease, bisulfite modification and methylation-CpG binding protein...
June 2017: Fa Yi Xue za Zhi
M A Hardisky, R J Reimold
Measurement of individual culms of several salt-marsh plants demonstrates seasonal community change in terms of height increments and live and dead leaves. Tissue production and its ultimate transition from live to dead components and culm mortality all suggest a continuum of geratologic processes contributing to the estuarine ecosystem.
November 11, 1977: Science
N A Wong, H W Jones
Renal impairment is common amongst elderly patients and increases the risk of drug toxicity. Analysis of the discharge summaries of patients discharged from the geratology wards of an Oxfordshire hospital, showed that renal impairment was not referred to in 42% of patients with calculated creatinine clearances of 10-20 ml/min. A fifth of these patients, and 67% of patients with calculated creatinine clearances < 10 ml/min, had discharge drug prescriptions that contradicted the British National Formulary guidelines for prescribing in the presence of renal impairment...
July 1998: Postgraduate Medical Journal
M K Thompson
Disease classes have hitherto been based on anatomical pathology and structural lesions belonging to an earlier ecological medical model involving classification. The diseases of ageing now coming to dominate clinical practice evolve across the clinical threshold in middle age parallel to changes occurring in the internal environment. The concept 'multiple pathology' used to describe the plural features of biological changes now requires new intellectual tools by which to understand overlap phenomena. Boolean algebra and Set Theory are proposed as the relevant enabling concepts, and their application to modern clinical practice is discussed...
March 1996: Age and Ageing
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