keyword
https://read.qxmd.com/read/38504996/the-frequency-and-timing-of-sepsis-associated-coagulopathy-in-the-neonatal-intensive-care-unit
#1
JOURNAL ARTICLE
Khyzer B Aziz, Matthew Saxonhouse, Divya Mahesh, Kathryn E Wheeler, James L Wynn
INTRODUCTION: Sepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated coagulopathy as well as its relationship to illness severity are unclear. METHODS: We performed a single-center, retrospective, observational cohort study of all infants admitted to the University of Florida Health (UF Health), level IV NICU between January 1st 2012 to March 1st 2020 to measure the frequency of sepsis-associated coagulopathy as well as its temporal relationship to critical illness in the NICU population...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38503661/vaccine-value-profile-for-klebsiella-pneumoniae
#2
JOURNAL ARTICLE
Ziyaad Dangor, Nicole Benson, James A Berkley, Julia Bielicki, Merijn W Bijsma, Jonathan Broad, Ed T Buurman, Alan Cross, Erin M Duffy, Kathryn E Holt, Pui-Ying Iroh Tam, Mark Jit, Konstantinos Karampatsas, Michael Katwere, Gaurav Kwatra, Ramanan Laxminarayan, Kirsty Le Doare, Robert Mboizi, Francesca Micoli, Catrin E Moore, Eve Nakabembe, Nichola R Naylor, Seamus O'Brien, Courtney Olwagen, Denasha Reddy, Charlene Rodrigues, David A Rosen, Manish Sadarangani, Padmini Srikantiah, Sharon M Tennant, Mateusz Hasso-Agopsowicz, Shabir A Madhi
Klebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infections is a concern for neonates and infants who are at high risk for invasive bacterial disease...
March 18, 2024: Vaccine
https://read.qxmd.com/read/38496060/transient-abnormal-myelopoiesis-an-abnormal-course-and-the-efficacy-of-delayed-treatment
#3
Purbasha Mishra, Mohamed Fajrudheen, Tanushree Sahoo, Tapas Kumar Som, Sandhya Biswal, Gaurav Chhabra
Transient abnormal myelopoiesis (TAM) is observed in a few neonates with Down syndrome. While a large proportion undergo complete remission without any treatment, some of them can develop myeloid leukemia of Down syndrome (ML-DS) in the future. Without proper treatment, mortality can be high. Here we have described an interesting and difficult-to-treat case of a neonatal with Down syndrome who presented with anemia, thrombocytopenia, and 75% blasts. We came across multiple challenges in treatment due to severe pneumonia...
February 2024: Curēus
https://read.qxmd.com/read/38477083/neonatal-diagnosis-of-congenital-dyserythropoietic-anemia-type-ii
#4
Apolline Lelard, Baptiste Le Calvez, Simon Bouzy, Marie Laure Couec, Marion Eveillard
No abstract text is available yet for this article.
March 13, 2024: International Journal of Laboratory Hematology
https://read.qxmd.com/read/38469773/a-case-report-of-neonatal-lupus-erythematosus-with-liver-function-damage-and-cytomegalovirus-colonization
#5
Fang Lan, Chengzhi Rong, Chunyun Fu, Yubing Wei, Weijun Yan, Xuehua Hu
BACKGROUND: Neonatal lupus erythematosus (NLE) is an acquired autoimmune disease. NLE with liver function damage and cytomegalovirus colonization is rarely reported. METHODS: This case describes a newborn male's laboratory testing found sustained liver function damage when he came to see the doctor due to oral candidiasis. The cause was identified through clinical symptoms, laboratory tests, auxiliary examinations, and family history of the patient. RESULTS: The final diagnosis of the child was NLE with liver function damage and cytomegalovirus colonization according to comprehensive analysis and follow-up observation...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38469760/role-of-systemic-immune-inflammatory-index-to-predict-intrahepatic-cholestasis-of-pregnancy
#6
JOURNAL ARTICLE
Seval Y Ergani, Sevki Celen
BACKGROUND: The goal was to investigate the change of systemic immune inflammation index (SII) in high-risk pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP). METHODS: Between May 2018 and April 2020, we retrospectively enrolled 218 pregnant women who were followed in our hospital from the first trimester to delivery. We looked at the sociodemographics, laboratory data, SII values, Apgar ratings, and newborn birth weights of pregnant women with ICP...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38459988/protective-effect-of-alpha%C3%A2-lipoic-acid-against-in-utero-cytarabine-exposure-induced-hepatotoxicity-in-rat-female-neonates
#7
JOURNAL ARTICLE
Ramanachary Namoju, Kavitha N Chilaka
Cytarabine, an anti-metabolite drug, remains the mainstay of treatment for hematological malignancies. It causes various toxic effects including teratogenicity. Alpha lipoic acid (ALA) is a natural antioxidant reported to offer protection against hepatotoxicity induced by various pathological conditions, drugs, or chemicals. We investigated the protective effect of ALA against prenatal cytarabine exposure-induced hepatotoxicity in rat female neonates. A total of 30 dams were randomly assigned to five groups and received normal saline, ALA 200 mg/kg, cytarabine 12...
March 9, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38451648/dental-caries-in-the-permanent-dentition-and-health-related-quality-of-life-among-children-and-adolescents-with-sickle-cell-disease
#8
JOURNAL ARTICLE
Vera Lúcia Duarte da Costa Mendes, Patrícia A Risso, Marcia Pereira Alves Dos Santos
The aim was to associate living, health and oral health conditions with the quality of life (QL) of children and adolescents (CA) with sickle cell disease (SCD). Of the 120 eligible users of a public hematological service, 106 CA with SCD from 6 to 18 years of age, and their caregivers, answered semi-structured questions about socio-demographic, health and oral health conditions. For QL, we used the validated instrument PedsQLSCD™. The oral clinical examination occurred according to the guidelines of WHO and SB Brazil 2010...
March 2024: Ciência & Saúde Coletiva
https://read.qxmd.com/read/38432651/a-career-in-solving-clinical-pathological-conundrums-heyde-syndrome-anti-platelet-factor-4-disorders-and-microvascular-limb-ischemic-necrosis
#9
REVIEW
Theodore E Warkentin
Hematology is a clinical specialty with strong roots in the laboratory; accordingly, the lab can help solve perplexing clinical problems. This review highlights clinical-pathological conundrums addressed during my 35-year hematology career at McMaster University. Heyde syndrome is the association between aortic stenosis and bleeding gastrointestinal (GI) angiodysplasia where the bleeding is usually cured by aortic valve replacement; the chance reading of a neonatal study showing reversible deficiency of high-molecular-weight (HMW) multimers of von Willebrand factor (vWF) following surgical correction of congenital heart disease provided the key insight that a subtle deficiency of HMW multimers of vWF explains Heyde syndrome...
March 3, 2024: International Journal of Laboratory Hematology
https://read.qxmd.com/read/38432308/circulating-nucleated-red-blood-cells-an-updated-reference-interval
#10
JOURNAL ARTICLE
Amy A Meredith, Neil R Meredith, Lynelle Smith, Julie Rosser
CONTEXT.—: Nucleated red blood cells (nRBCs) are not identified in the peripheral blood in healthy individuals beyond the neonatal period. Their presence in children and adults is traditionally considered pathologic. Contemporary hematology analyzers measure nRBCs at very low levels compared to traditional manual morphometric methods. The original launch of the Sysmex XN analyzer in this study's clinical laboratory verified the previously used nRBC reference interval of 0.00 to 0...
March 4, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38432196/neonatal-extracorporeal-membrane-oxygenation-associations-between-continuous-renal-replacement-therapy-thrombocytopenia-and-outcomes
#11
JOURNAL ARTICLE
Lauren R Walker, Laura E Hollinger, W Michael Southgate, David T Selewski, Jeffrey E Korte, Mathew Gregoski, Heidi J Steflik
INTRODUCTION: The incidence of thrombocytopenia in neonates receiving extracorporeal membrane oxygenation (ECMO) with and without concurrent continuous renal replacement therapy (CRRT) and associated complications have not been well described. The primary aims of the current study were to (1) characterize thrombocytopenia in neonates receiving ECMO (including treated concurrently with CRRT) and (2) evaluate risk factors (including CRRT utilization) associated with severe thrombocytopenia...
March 1, 2024: Blood Purification
https://read.qxmd.com/read/38419273/evaluation-of-the-impact-of-diagnostic-blood-loss-and-red-blood-cell-transfusion-in-very-low-birth-weight-anaemic-neonates-during-hospitalization-a-multi-centre-retrospective-clinical-study
#12
JOURNAL ARTICLE
Ting Ma, Jiangcun Yang, Yang Sun, Aowei Song, Jin Zhang, Yuan Shen, Kai Hua, Wenjing Wu, Wei Chen
BACKGROUND AND OBJECTIVES: Diagnostic blood loss is a significant factor in the development of anaemia in neonates with very low birth weight. This study aimed to assess the clinical efficacy of intervention approaches involving varying diagnostic blood loss and red blood cell transfusion volumes in neonates with very low birth weights experiencing anaemia during hospitalization. MATERIALS AND METHODS: A total of 785 newborns with anaemia weighing less than 1500 g were enrolled from 32 hospitals in China...
February 28, 2024: Vox Sanguinis
https://read.qxmd.com/read/38411864/prevalence-of-thalassemia-carrier-couples-and-fertility-risk-assessment
#13
JOURNAL ARTICLE
Liu-Song Wu, Xi Luo, Mei Tan, Li-Jun Zhang, Hong-Fang Luo, Ge Huang, Pei Huang, Jindong Chen, Yan Chen
Thalassemia is a highly prevalent hematologic disease in Guizhou, China. This study aimed to determine the epidemiological characteristics of thalassemia in couples at childbearing age and assess the neonatal risk of thalassemia in this subpopulation. A cohort of 4481 couples at childbearing age were recruited for thalassemia carrier screening by both traditional hematological tests and next-generation sequencing. Of them, 1314 (14.66%) thalassemia carriers were identified, including 857 (9.76%) α-thalassemia, 391 (4...
February 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38407610/natural-history-of-human-platelet-antigen-1a-alloimmunised-pregnancies-a-prospective-observational-cohort-study
#14
JOURNAL ARTICLE
Thijs W de Vos, Dian Winkelhorst, Leendert Porcelijn, Mila Beaufort, Gonda Oldert, Johanna G van der Bom, Enrico Lopriore, Dick Oepkes, Masja de Haas, Ellen van der Schoot
BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that untreated can lead to intracranial haemorrhage or death. The natural history of FNAIT is still unclear; therefore, the benefits of screening cannot be estimated and no routine screening is yet in place. We aimed to assess the incidence of clinically detectable FNAIT among pregnancies in human platelet antigen-1a (HPA-1a)-immunised women. METHODS: We did a prospective observational cohort study of pregnant women negative for rhesus D (RhD) and rhesus c (Rhc) antigens, without age limits, who underwent routine antenatal screening for red cell antibodies at 27 weeks' gestation and were typed for HPA-1a between March 1, 2017, and May 1, 2020...
December 2023: Lancet Haematology
https://read.qxmd.com/read/38406995/in-premature-rupture-of-membranes-maternal-serum-delta-neutrophil-index-may-be-a-predictive-factor-for-histological-chorioamnionitis-and-affect-fetal-inflammatory-markers-a-retrospective-cross-sectional-study
#15
JOURNAL ARTICLE
Yusuf Dal, Şebnem Karagün, Fatih Akkuş, Hatun Çolak, Hakan Aytan, Ayhan Coşkun
PROBLEM: We aimed to investigate the predictive value of delta neutrophil index (DNI) for histological choriomanionitis (HCAM) and the effect of maternal inflammatory markers on neonatal outcomes and fetal inflammatory parameters. METHOD OF STUDY: In this retrospective cross-sectional study, 68 pregnant women without HCAM (group 1) and 46 pregnant women diagnosed with HCAM (group 2) were divided into two groups. Demographic stories of the groups; maternal hematological parameters; maternal DNI and systemic inflammatory index (SII) values; outcomes of newborns; fetal inflammatory markers were recorded and compared between groups...
February 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38405245/comparison-of-the-surgical-outcomes-in-neonates-with-left-sided-congenital-diaphragmatic-hernia-with-only-skin-closure-versus-abdominal-muscle-closure
#16
JOURNAL ARTICLE
Sravanthi Vutukuru, Prema Menon, Shailesh Solanki
AIM: This study aims to compare the outcome of neonatal left congenital diaphragmatic hernia (CDH, Bochdalek type) repair through laparotomy with and without abdominal muscle closure. MATERIALS AND METHODS: This retrospective study was conducted between January 2012 and May 2021 at a neonatal surgical unit of a Tertiary Care Center. Demographic details, preoperative management, Two-dimensional-echo, intra-operative findings, postoperative course, and follow-up data were collected and analyzed...
2024: Journal of Indian Association of Pediatric Surgeons
https://read.qxmd.com/read/38400657/generation-of-human-antibodies-targeting-human-platelet-antigen-hpa-1a
#17
JOURNAL ARTICLE
Janita J Oosterhoff, Federica Linty, Remco Visser, Thijs de Vos, Suzanne Hofstede-van Egmond, Miranda van de Weerd, Leendert Porcelijn, Masja de Haas, Ellen van der Schoot, Gestur Vidarsson
BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition during pregnancy, which can lead to thrombocytopenia and a bleeding tendency with intracranial hemorrhage (ICH) being the most concerning complication in the fetus or neonate. An incompatibility between human platelet antigen (HPA)-1a accounts for the majority of FNAIT cases. Binding of HPA-1a-specific alloantibodies to their target on fetal platelets and endothelial cells can induce apoptosis of megakaryocytes, disrupt platelet function, and impair angiogenesis...
February 24, 2024: Transfusion
https://read.qxmd.com/read/38396839/current-understanding-of-immune-thrombocytopenia-a-review-of-pathogenesis-and-treatment-options
#18
REVIEW
Alina Mititelu, Minodora-Cezarina Onisâi, Adrian Roșca, Ana Maria Vlădăreanu
The management of immune thrombocytopenia (ITP) and the prediction of patient response to therapy still represent a significant and constant challenge in hematology. ITP is a heterogeneous disease with an unpredictable evolution. Although the pathogenesis of ITP is currently better known and its etiology has been extensively studied, up to 75% of adult patients with ITP may develop chronicity, which represents a significant burden on patients' quality of life. A major risk of ITP is bleeding, but knowledge on the exact relationship between the degree of thrombocytopenia and bleeding symptoms, especially at a lower platelet count, is lacking...
February 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38389107/impact-of-litter-size-on-the-hematological-and-iron-status-of-gilts-sows-and-newborn-piglets-a-comparative-study-of-domestic-pigs-and-wild-boars
#19
JOURNAL ARTICLE
Zuzanna Kopeć, Rafał Mazgaj, Rafał Radosław Starzyński, Xiuying Wang, Jolanta Opiela, Zdzisław Smorąg, Barbara Gajda, Jakub Nicpoń, Małgorzata Lenartowicz, Magdalena Ogłuszka, Mikołaj Antoni Gralak, Paweł Lipiński
BACKGROUND: The critically low hepatic iron stores of newborn piglets are considered to be a major cause of neonatal iron deficiency in modern breeds of domestic pig (Sus domestica). The main factor believed to contribute to this phenomenon is large litter size, which has been an objective of selective breeding of pigs for decades. As consequence, iron transferred from the pregnant sow has to be distributed among a greater number of fetuses. RESULTS: Here, we investigated whether litter size influences red blood cell (RBC) indices and iron parameters in Polish Large White (PLW) piglets and gilts...
February 23, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38388746/transfusion-of-blood-components-in-pediatric-age-groups-an-evidence-based-clinical-practice-guideline-adapted-for-the-use-in-egypt-using-adapted-adapte
#20
JOURNAL ARTICLE
Galila Mokhtar, Amira Adly, Ashraf Abdel Baky, Dina Ezzat, Gehan Abdel Hakeem, Hoda Hassab, Ilham Youssry, Iman Ragab, Ivan Florez, Laila M Sherief, Magdy El-Ekiaby, Marwa Zakaria, Mervat Hesham, Naglaa Shaheen, Niveen Salama, Nouran Salah, Rasha A A Afifi, Rasha El-Ashry, Salwa Youssef, Seham Ragab, Sonia A Habib, Tarek Omar, Yasser Amer, Yasser Wali, Sara Makkeyah
Pediatric transfusion is a complex area of medicine covering a wide age range, from neonates to young adults. Compared to adult practice, there is a relative lack of high-quality research to inform evidence-based guidelines. We aimed to adapt the pre-existing high-quality practice guidelines for the transfusion of blood components in different pediatric age groups to be available for national use by general practitioners, pediatricians, and other health care professionals. The guideline panel included 17 key leaders from different Egyptian institutions...
February 22, 2024: Annals of Hematology
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