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https://www.readbyqxmd.com/read/27805995/rapid-thrombelastography-r-teg-thresholds-for-goal-directed-resuscitation-of-patients-at-risk-for-massive-transfusion
#1
Peter M Einersen, Ernest E Moore, Michael P Chapman, Hunter B Moore, Eduardo Gonzalez, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Uncontrolled hemorrhage is a leading cause of mortality following trauma accounting for up to 40% of deaths. Massive transfusion protocols (MTPs) offer a proven benefit in resuscitation of these patients. Recently, the superiority of thrombelastography (TEG)-guided resuscitation over strategies guided by conventional clotting assays (CCA) has been established. We seek to determine optimal thresholds for r-TEG driven resuscitation. METHODS: R-TEG data were reviewed for 190 patients presenting to our Level 1 Trauma Center from 2010 to 2015...
October 31, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27789243/proteomic-and-transcriptomic-investigation-of-acne-vulgaris-microcystic-and-papular-lesions-insights-in-the-understanding-of-its-pathophysiology
#2
Jusal Quanico, Jean-Pascal Gimeno, Florence Nadal-Wollbold, Christiane Casas, Sandrine Alvarez-Georges, Daniel Redoulès, Anne-Marie Schmitt, Isabelle Fournier, Michel Salzet
BACKGROUND: The pathogenesis of acne vulgaris involves several phases including androgen-dependent hyper-seborrhea, colonization by Propionibacterium acnes, and inflammation. Recent investigations have shown that in fact P. acnes provokes the activation of the inflammasome present in macrophages and dendritic cells. This signaling pathway leads to excessive production of interleukin IL-1β, a proinflammatory cytokine. Nevertheless, these well-studied phenomena in acne fail to elucidate the mechanisms responsible for the appearance of different lesions...
October 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27783497/the-classification-of-gunshot-residue-using-laser-electrospray-mass-spectrometry-and-offline-multivariate-statistical-analysis
#3
Johnny J Perez, David A Watson, Robert J Levis
Nonresonant laser vaporization combined with high resolution time-of-flight mass spectrometry enables analysis of a casing after discharge of a firearm revealing organic signature molecules including methyl centralite (MC), diphenylamine (DPA), N-nitrosodiphenylamine (N-NO-DPA), 4-nitrodiphenylamine (4-NDPA), a DPA adduct and multiple unidentified features not observed in previous mass spectral measurements. Collision-induced dissociation measurements of unknown GSR signature ions reveals inorganic barium and derivatives BaOH, BaOHCH3, BaCH3COO remaining from the primer...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27752640/near-complete-optic-nerve-transection-by-high-pressure-air
#4
Soo Won Ko, Jong Seok Lee, Han Sung Choi, Young Gwan Ko, Hoon Pyo Hong
The use of high-pressure air instruments has become more common. Consequently, there have been a number of cases of orbital emphysema caused by contact with high-pressure air. In this case, a 62-year-old male patient visited an emergency medical center after his left eye was shot by an air compressor gun that was used to wash cars. Lacerations were observed in the upper and lower eyelids of his left eye. Radiological examinations revealed orbital emphysema, optic nerve transection, pneumocephalus, and subcutaneous emphysema in the face, neck, shoulder, and mediastinum...
September 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27744527/bullet-fragmentation-preceding-a-contour-shot-case-study-and-experimental-simulation
#5
V Sterzik, B P Kneubuehl, M Bohnert, F Riva, M Glardon
In medico-legal literature, only a small number of publications deal with lethal injuries caused by shots with modified guns. This might lead to the conclusion that such cases are extremely rare. However, there are cases again and yet again. During the investigation process, the modified gun is of particular importance since it can show an unusual ballistic behaviour. The present paper reports on a suicide of a 60-year-old man, committed with a modified revolver and a lead bullet. The man had a single gunshot wound with entrance at the right temporal bone...
October 15, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27721003/quadriparesis-caused-by-lead-poisoning-nine-years-after-a-gunshot-wound-with-retained-bullet-fragments-a-case-report
#6
Emma Nally, James Jelinek, Robert D Bunning
: Lead toxicity in adults is characterized by nonspecific symptoms of abdominal pain, vomiting, constipation, fatigue, and weight loss. We present a case of severe lead toxicity that developed subacutely, causing quadriparesis 9 years after a gunshot wound with retained bullet fragments. The onset of symptoms may have been related to the development of a pseudocyst. The long interval between the gunshot wound and the onset of symptoms contributed to a delay in suspecting that the retained bullet was a source of lead toxicity...
October 6, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27720822/genetic-basis-for-high-population-diversity-in-protea-associated-knoxdaviesia
#7
Janneke Aylward, Emma T Steenkamp, Léanne L Dreyer, Francois Roets, Michael J Wingfield, Brenda D Wingfield
Sexual reproduction is necessary to generate genetic diversity and, in ascomycete fungi, this process is controlled by a mating type (MAT) locus with two complementary idiomorphs. Knoxdaviesia capensis and K. proteae (Sordariomycetes; Microascales; Gondwanamycetaceae) are host-specific saprophytic fungi that show high population diversity within their Protea plant hosts in the Cape Floristic Region of South Africa. We hypothesise that this diversity is the result of outcrossing driven by a heterothallic mating system and sought to describe the MAT1 loci of both species...
October 5, 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27715652/the-effect-of-body-armor-on-saving-officers-lives-an-analysis-using-leoka-data
#8
Weiwei Liu, Bruce Taylor
Using the Law Enforcement Officers Killed and Assaulted (LEOKA; 2002-2011) database, we examined the life-saving effectiveness of body armor while adjusting for a range of confounders not assessed in previous studies. Among the 637 officers who were shot by a firearm at the torso, those who wore body armor were 76% less likely to be killed than those who did not wear armor, controlling for an array of individual and incident characteristics. A number of factors influenced officers' armor wearing behavior include age, BMI, rank, geographic region, and type of assignment...
February 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27673104/poster-350-persistent-pneumocephalus-after-gun-shot-wound-to-the-head
#9
Kunj G Patel, Lauren E Brandes, Srikanth Kurapati, Emily Boyd, Andrew C Dennison
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27663479/using-reverse-phase-protein-arrays-as-pharmacodynamic-assays-for-functional-proteomics-biomarker-discovery-and-drug-development-in-cancer
#10
REVIEW
Yiling Lu, Shiyun Ling, Apurva M Hegde, Lauren A Byers, Kevin Coombes, Gordon B Mills, Rehan Akbani
The majority of the targeted therapeutic agents in clinical use target proteins and protein function. Although DNA and RNA analyses have been used extensively to identify novel targets and patients likely to benefit from targeted therapies, these are indirect measures of the levels and functions of most therapeutic targets. More importantly, DNA and RNA analysis is ill-suited for determining the pharmacodynamic effects of target inhibition. Assessing changes in protein levels and function is the most efficient way to evaluate the mechanisms underlying sensitivity and resistance to targeted agents...
August 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27630138/nonfatal-gun-use-in-intimate-partner-violence-a-systematic-review-of-the-literature
#11
Susan B Sorenson, Rebecca A Schut
Guns figure prominently in the homicide of women by an intimate partner. Less is known, however, about their nonfatal use against an intimate partner. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched eight electronic databases and identified 10 original research articles that reported the prevalence of the nonfatal use of firearms against an intimate partner. Results indicate that (1) there is relatively little research on the subject of intimate partners' nonfatal gun use against women...
September 14, 2016: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/27622112/pediatric-arm-reconstruction-after-shot-gun-injury-using-peroneal-free-flap-and-pedicled-latissimus-dorsi-muscle-flap-late-follow-up
#12
Carlos Olvera-Caballero, Abel Ortiz-Dominguez
A 15-year-old patient harmed himself upon firing a shotgun that he was carrying when he slipped and fell, causing a destructive wound in the right arm with a medial entry hole and a posterolateral exit hole. The biceps, coracobrachialis, triceps, deltoids, skin cover, and humerus were injured; however, the blood vessels and major nerves of the area were surprisingly not affected. The residual skin muscle defect after debridements was 16 × 5 cm medially and posteriorly, and the bone loss was 7 cm. The wound was reconstructed during a single surgery with a free fibula flap and a pedicled flap of latissimus dorsi...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27598599/air-gun-pellet-cardiac-penetration-and-peripheral-embolization
#13
Onur Işık, Çağatay Engin, Ahmet Daylan, Cengiz Şahutoğlu
Use of high-velocity air guns can to lead to serious injuries. Management options of cardiac pellet gun injuries are based on patient stability, and course and location of the pellet. Presently reported is the case of a boy who was shot with an air gun pellet. Following right ventricular entry, the pellet lodged in the left atrium and embolized to the right iliac and femoral artery. Following pellet localization, right ventricular injury was repaired, and the pellet was removed successfully.
May 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27595912/bal31-ngs-approach-for-identification-of-telomeres-de-novo-in-large-genomes
#14
Vratislav Peška, Zdeňka Sitová, Petr Fajkus, Jiří Fajkus
This article describes a novel method to identify as yet undiscovered telomere sequences, which combines next generation sequencing (NGS) with BAL31 digestion of high molecular weight DNA. The method was applied to two groups of plants: i) dicots, genus Cestrum, and ii) monocots, Allium species (e.g. A. ursinum and A. cepa). Both groups consist of species with large genomes (tens of Gb) and a low number of chromosomes (2n=14-16), full of repeat elements. Both genera lack typical telomeric repeats and multiple studies have attempted to characterize alternative telomeric sequences...
September 2, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27593715/acquired-spinal-arteriovenous-fistula-presenting-as-brown-s%C3%A3-quard-syndrome-and-endovascular-treatment-outcome
#15
Rizvi Humaira, Chiu Yuen To, Shyam Moudgil, Richard Fessler
BACKGROUND: Brown-Séquard syndrome is typically caused by penetrating trauma to the cervical spinal cord; however, other compressive and vascular occlusive etiologies have been previously described. It is extremely uncommon to have a delayed presentation as an extramedullary compressive lesion from the venous varix of an acquired spinal arteriovenous fistula. CASE DESCRIPTION: We present a case of a patient in the fifth decade of life, with a remote history of gunshot wound to the left thorax with progressive left-sided weakness and contralateral pain and temperature sensory loss secondary to cord compression from an acquired spinal arteriovenous fistula...
September 2, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27591065/airgun-shot-wound-to-the-orbit-with-retention-of-pellet-case-report-and-review-of-the-literature
#16
Paweł Daszkiewicz, Dariusz Dziedzic, Piotr Daszkiewicz
Shot wounds become a growing clinical concern in the civilian setting, due to increasing popularity of air guns among minors. We present a pediatric case of a shot wound to the orbit with sparing of the eyeball and retention of airgun pellet in the retrobulbar space. The pellet was removed 3 months after injury via lateral orbitotomy. Pathophysiology and ballistics of shot wounds are briefly reviewed and current views on the management strategy of shot wounds with retained projectile are discussed.
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27546337/surgical-resection-for-epilepsy-following-cerebral-gun-shot-wounds
#17
Yoshua Esquenazi, Giridhar P Kalamangalam, Omotola A Hope, Sonia N Krish, Jeremy Slater, Nitin Tandon
OBJECTIVE: The surgical management of epilepsy following penetrating gunshot wounds (GSWs) to the head has not been described in the modern; era. Given the extensive damage to the cranium and cortex from such; injuries, the safety and efficacy of surgical intervention is unclear. We; report the surgical strategy and outcomes following resections for; medically refractory epilepsy following GSWs in four patients. METHODS: A prospectively compiled database of 325 epilepsy patients was used to identify patients undergoing epilepsy surgery for medically; refractory epilepsy following a GSW to the brain...
August 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27448569/influence-of-pellet-seating-on-the-external-ballistic-parameters-of-spring-piston-air-guns
#18
Ronald Werner, Benno Schultz, Matthias Frank
In firearm examiners' and forensic specialists' casework as well as in air gun proof testing, reliable measurement of the weapon's muzzle velocity is indispensable. While there are standardized and generally accepted procedures for testing the performance of air guns, the method of seating the diabolo pellets deeper into the breech of break barrel spring-piston air guns has not found its way into standardized test procedures. The influence of pellet seating on the external ballistic parameters was investigated using ten different break barrel spring-piston air guns...
September 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27444998/-pest-control-in-your-garden-a-case-series-of-severe-hand-injuries-caused-by-privately-used-explosives-and-shot-traps
#19
S Könneker, N Krezdorn, P M Vogt, M A Altintas, M T Hiller, R Ipaktchi, C Radtke
Booby traps and gun-like devices for vole control can lead to complex trauma requiring emergency medical care. We present a case series of patients who suffered severe hand and facial trauma through detonation of booby traps and paraphernalia (n = 9, Ø 60 years of age). All patients were admitted to the emergency department of Hannover Medical School for primary care. Between 2011 and 2015 we treated six patients with hand trauma due to gun-like devices, two patients with hand trauma due to booby traps, and one patient with injury to the face including eyes due to a gas cartridge explosion...
October 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27434956/-characteristics-of-antibioticoresistance-of-microflora-in-a-combat-the-gun-shot-ano-the-mine-explosion-wounds-of-the-extremities
#20
V M Kondratyuk
Abstract Results of bacteriological investigations of a gun-shot and a mine-explosion woundings of the extremities were analyzed in Military-Medical Clinical Centres (MMCC) of Kyiv, Lviv and Vinnytsya. Spectrum of the allotted microorganisms and profile of their antibioticoresistance were disclosed. The patterns of resistance were determined in accordance to offering of international experts of European Committee on Antimicrobial Susceptibility Testing (EUCAST). Dominating microflora in a Chief MMCC (Kyiv) and MMCC of a Western Region (Lviv) were various species of the Enterobacteriaceae and P...
April 2016: Klinichna Khirurhiia
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