Syed Ali Raza Naqvi, Tania Jabbar, Maha A Alharbi, Asma Noureen, Nada K Alharbi, Tauqir A Sherazi, Anum Shahzadi, Ahmed Ezzat Ahmed, M Shahzad Afzal, M Babar Imran
Ertapenem is a member of carbapenem antibiotics used for the treatment of moderate-to-severe intra-abdominal, urinary tract, acute pelvic, and post-surgical gynecologic infections. The antibacterial activity of ertapenem is mediated through binding to penicillin-binding proteins which results in inhibiting the cross-linking of the peptidoglycan layer of the bacterial cell wall. Therefore, ertapenem can be labeled with technetium-99m (99m Tc), a gamma emitter radionuclide, for the diagnosis of deep-seated bacterial infections, such as urinary tract, intra-abdominal, osteomyelitis, and post-surgical gynecologic infections...
2022: Frontiers in Chemistry