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https://www.readbyqxmd.com/read/29035150/enhancement-of-carotenoids-and-lipids-production-by-oleaginous-red-yeast-sporidiobolus-pararoseus-km281507
#1
Thanongsak Chaiyaso, Atchara Manowattana
Bioconversion of biodiesel-derived crude glycerol into carotenoids and lipids was investigated by a microbial conversion of an oleaginous red yeast Sporidiobolus pararoseus KM281507. The methanol content in crude glycerol (0.5% w/v) did not show a significant effect on biomass production by strain KM281507. However, demethanolized crude glycerol significantly supported the production of biomass (8.64 ± 0.13 g/L), lipids (2.92 ± 0.03 g/L), β-carotene (15.76 ± 0.85 mg/L) and total carotenoids (33...
October 16, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29021813/effect-of-a-short-term-dietary-supplementation-with-phytosterols-red-yeast-rice-or-both-on-lipid-pattern-in-moderately-hypercholesterolemic-subjects-a-three-arm-double-blind-randomized-clinical-trial
#2
Arrigo F G Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D'Addato, Claudio Borghi
BACKGROUND: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. METHODS: We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from Monascus purpureus (group 2), or both combined nutraceuticals (group 3)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28944737/alginate-gelatin-formulation-to-modify-lovastatin-release-profile-from-red-yeast-rice-for-hypercholesterolemia-therapy
#3
Gemma Leone, Marco Consumi, Simone Pepi, Stefania Lamponi, Claudia Bonechi, Gabriella Tamasi, Alessandro Donati, Claudio Rossi, Agnese Magnani
AIM: The preparation of a delivery system able to guarantee a delayed release of lovastatin from red yeast rice (RYR) is mandatory to counteract cholesterol biosynthesis effectively. MATERIALS & METHODS: Polymeric formulations were prepared mixing alginate and gelatin, in different ratios, with RYR. The effect of different composition on stiffness, viscosity, swelling behavior and mesostructure of matrices was analyzed. RESULTS: Formulations obtained combining polymers in comparable amount (i...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28934253/xuezhikang-contributes-to-greater-triglyceride-reduction-than-simvastatin-in-hypertriglyceridemia-rats-by-up-regulating-apolipoprotein-a5-via-the-ppar%C3%AE-signaling-pathway
#4
Shui-Ping Zhao, Rong Li, Wen Dai, Bi-Lian Yu, Lu-Zhu Chen, Xian-Sheng Huang
Xuezhikang (XZK), an extract of Chinese red yeast rice, is recommended as an optimal choice for patients with coronary heart disease (CHD) with markedly elevated triglyceride (TG) levels. This study was designed to compare the hypotriglyceridemic effects between XZK and simvastatin. The role of apolipoprotein A5 (apoA5), a key regulator of TG metabolism and a target gene of peroxisome proliferator-activated receptor α (PPARα), was to be identified in XZK-related hypotriglyceridemic actions. For these goals, hypertriglyceridemia of rats was induced by a high-fructose diet...
2017: PloS One
https://www.readbyqxmd.com/read/28861889/red-yeast-rice-prevents-atherosclerosis-through-regulating-inflammatory-signaling-pathways
#5
Min Wu, Wen-Gao Zhang, Long-Tao Liu
OBJECTIVE: To observe the effects of red yeast rice (RYR) on blood lipid levels, aortic atherosclerosis (AS), and plaque stability in apolipoprotein E gene knockout (ApoE-/-) mice. METHODS: Twenty-four ApoE-/- mice were fed with a high-fat diet starting from 6 weeks of age. Mice were randomized into three groups (n = 8 in each group): model group (ApoE-/- group), RYR group (ApoE-/- + RYR group), and simvastatin group (ApoE-/- + simvastatin group). Eight 6-week-old C57BL/6 mice were assigned as the control group and fed with a basic diet...
September 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28858885/recent-perspectives-on-the-role-of-nutraceuticals-as-cholesterol-lowering-agents
#6
Natalie Ward, Amirhossein Sahebkar, Maciej Banach, Gerald Watts
PURPOSE OF REVIEW: Reduction in circulating cholesterol is an important step in lowering cardiovascular risk. Although statins are the most frequently prescribed cholesterol-lowering medication, there remains a significant portion of patients who require alternative treatment options. Nutraceuticals are increasingly popular as cholesterol-lowering agents. Despite the lack of long-term trials evaluating their use on cardiovascular endpoints and mortality, several studies have demonstrated their potential cholesterol-lowering effects...
December 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28827048/bioconversion-of-biodiesel-derived-crude-glycerol-into-lipids-and-carotenoids-by-an-oleaginous-red-yeast-sporidiobolus-pararoseus-km281507-in-an-airlift-bioreactor
#7
Atchara Manowattana, Charin Techapun, Masanori Watanabe, Thanongsak Chaiyaso
Here we tested the bioconversion of biodiesel-derived crude glycerol by the oleaginous red yeast Sporidiobolus pararoseus KM281507 in two bioreactors types (stirred-tank and airlift). High production yields (biomass, 10.62 ± 0.21 g/L; lipids, 3.26 ± 0.13 g/L; β-carotene, 30.64 ± 0.05 mg/L; total carotenoids, 46.59 ± 0.07 mg/L) were achieved in a 3.0 L airlift bioreactor under uncontrolled pH regimes (initial pH 5.63). Under optimized conditions (6.0 vvm aeration rate; 60 ± 5% constant dissolved oxygen [DO] maintained by flushing pure oxygen [O2] into the vessel; 10,000 Lux light irradiation) volumetric production in the airlift bioreactor was further increased (biomass, 19...
August 18, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28781026/comparison-of-low-dose-statin-versus-low-dose-statin%C3%A2-%C3%A2-armolipid-plus-in-high-intensity-statin-intolerant-patients-with-a-previous-coronary-event-and-percutaneous-coronary-intervention-adherence-trial
#8
RANDOMIZED CONTROLLED TRIAL
Giuseppe Marazzi, Giuseppe Campolongo, Francesco Pelliccia, Silvia Quattrino, Cristiana Vitale, Luca Cacciotti, Rosalba Massaro, Maurizio Volterrani, Giuseppe Rosano
Low-density lipoprotein cholesterol (LDL-C) reduction is associated with a significant decrease in mortality, and statins represent the most effective drugs to achieve this. However, side effects of statins are very common and may lead to treatment discontinuation. Nutraceuticals are a combination of natural components that have shown efficacy in lowering LDL-C concentration when used alone or in association with other agents in patients who are intolerant to high-dose statins. Our aim was to compare the efficacy and tolerability of low-dose statin (LDS) therapy versus combined therapy of LDS plus a nutraceutical combination containing red yeast rice, policosanol, berberine, folic acid, coenzyme Q10 and astaxanthin (Armolipid Plus) in high-risk patients...
September 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28763948/increased-torulene-accumulation-in-red-yeast-sporidiobolus-pararoseus-ngr-as-stress-response-to-high-salt-conditions
#9
Chunji Li, Ning Zhang, Bingxue Li, Qiong Xu, Jia Song, Na Wei, Wenjing Wang, Hongtao Zou
Carotenoids represent a class of molecules valuable for food, chemical and pharmaceutical industries. As a microbial carotenoid, torulene possesses potential health-promoting effects in human. However, few studies have been conducted to investigate optimal condition for its large-scale commercial production to date. Sporidiobolus pararoseus NGR, a pigmented yeast, was shown previously to accumulate considerable amounts of torulene, β-carotene, and torularhodin. In this study, the effect of salt stress on the production of carotenoids in S...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28749884/original-research-the-effects-of-red-yeast-rice-supplementation-on-cholesterol-levels-in-adults
#10
REVIEW
Diane Peng, Amy Fong, Amanda van Pelt
: Purpose: Red yeast rice (RYR) supplementation has become a popular alternative to statin therapy in treating hypercholesterolemia. This state-of-the-science review seeks to explore the most recent evidence on the effectiveness and safety of RYR supplementation in treating dyslipidemic adults. METHODS: This review extends the time frame of a meta-analysis performed by Li and colleagues in 2014; specifically, we looked at the literature published between September 2013 and April 2016...
August 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28738573/stable-isotope-ratio-analysis-for-authentication-of-red-yeast-rice
#11
Matteo Perini, Gianfranco Carbone, Federica Camin
Red yeast rice (RYR) is a dietary supplement obtained from rice fermented with the mould Monascus purpureus. It contains Monacolin K which is a hypocholesterolemic statin used to prevent cardiovascular diseases. The homologous prescription biosynthetic statin, lovastatin, is not chemically distinguishable from monacolin K. In this work we investigated whether δ(13)C and δ(2)H can distinguish monacolin K from lovastatin and can detect the presence of lovastatin in RYR. 18 samples of red yeast rice powder and 18 samples of lovastatin were collected...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28704936/effects-of-a-new-nutraceutical-formulation-berberine-red-yeast-rice-and-chitosan-on-non-hdl-cholesterol-levels-in-individuals-with-dyslipidemia-results-from-a-randomized-double-blind-placebo-controlled-study
#12
Valentina Spigoni, Raffaella Aldigeri, Monica Antonini, Maria Maddalena Micheli, Federica Fantuzzi, Andrea Fratter, Marzia Pellizzato, Eleonora Derlindati, Ivana Zavaroni, Riccardo C Bonadonna, Alessandra Dei Cas
Increased non high-density lipoprotein (HDL)/low-density lipoprotein (LDL) cholesterol levels are independent risk factors for cardiovascular (CV) mortality with no documented threshold. A new combination of nutraceuticals (berberine 200 mg, monacolin K 3 mg, chitosan 10 mg and coenzyme Q 10 mg) with additive lipid-lowering properties has become available. The aim of the study is to test the efficacy of the nutraceutical formulation (one daily) in lowering non-HDL cholesterol vs. placebo at 12 weeks in individuals with non-HDL-cholesterol levels ≥160 mg/dL...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28687937/short-term-effects-of-a-combined-nutraceutical-on-lipid-level-fatty-liver-biomarkers-hemodynamic-parameters-and-estimated-cardiovascular-disease-risk-a-double-blind-placebo-controlled-randomized-clinical-trial
#13
Arrigo F G Cicero, Federica Fogacci, Marilisa Bove, Maddalena Veronesi, Manfredi Rizzo, Marina Giovannini, Claudio Borghi
INTRODUCTION: There is a growing interest in nutraceuticals improving cardiovascular risk factor levels and related organ damage. METHODS: This double-blind, placebo-controlled randomized clinical trial aims to compare the effect of a combined nutraceutical containing red yeast rice (10 mg), phytosterols (800 mg), and L-tyrosol (5 mg) on lipid profile, blood pressure, endothelial function, and arterial stiffness in a group of 60 patients with polygenic hypercholesterolemia resistant to Mediterranean diet...
August 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28673363/a-red-yeast-rice-olive-extract-supplement-reduces-biomarkers-of-oxidative-stress-oxldl-and-lp-pla2-in-subjects-with-metabolic-syndrome-a-randomised-double-blind-placebo-controlled-trial
#14
Nina Hermans, Anastasia Van der Auwera, Annelies Breynaert, Annelies Verlaet, Tess De Bruyne, Luc Van Gaal, Luc Pieters, Veronique Verhoeven
BACKGROUND: Metabolic syndrome (MetS) refers to clustered cardiovascular risk factors (abdominal obesity, pre-diabetes, high blood pressure, dyslipidaemia). Therapies targeting oxidative stress may delay progression to atherosclerosis and diabetes. We investigated the anti-oxidative effect of a supplement combining red yeast rice and olive extract in patients with MetS. METHODS: A double-blind, placebo-controlled, randomised trial was conducted with 50 patients with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III criteria...
July 3, 2017: Trials
https://www.readbyqxmd.com/read/28641460/variability-in-strength-of-red-yeast-rice-supplements-purchased-from-mainstream-retailers
#15
Pieter A Cohen, Bharathi Avula, Ikhlas A Khan
The United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supplements, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient identical to prescription lovastatin. We examined whether FDA's manufacturing standards led to standard concentrations of the statin monacolin K in red yeast rice supplements. We analyzed 28 brands of red yeast rice supplements by ultra-high performance liquid chromatography-diode array detector-quadrupole time-of-flight mass spectrometry for monacolin K content...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28617172/food-supplements-with-red-yeast-rice-more-regulations-are-needed
#16
Guy G De Backer
No abstract text is available yet for this article.
September 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28608538/effects-of-dietary-red-yeast-sporidiobolus-pararoseus-on-production-performance-and-egg-quality-of-laying-hens
#17
W Tapingkae, K Panyachai, M Yachai, H V Doan
The purpose of this study was to evaluate the effect of dietary red yeast (Sporidiobolus pararoseus) on production performance and egg quality of laying hens. A total of 200 Esa Brown laying hens (23 weeks of age) were allocated equally to negative control group (no yeast supplement); positive control group (2 g/kg of Saccharomyces cerevisiae); 0.5, 1, 2 g/kg red yeast respectively. The experiment was lasted for 12 weeks. Feed intake, hen-day egg production and egg weight were not different between control and supplemented groups...
June 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28601545/red-yeast-rice-preparations-are-they-suitable-substitutions-for-statins
#18
REVIEW
Carlos A Dujovne
Red yeast rice, a commercially available food supplement known to reduce serum cholesterol, has been repeatedly advocated as alternative therapy for hypercholesterolemic patients that refuse statins, cannot tolerate statin therapy's side effects, or request a "naturopathic" medicine. Red yeast rice contains a fungus (Monascus purpureus), which was utilized in the original production of lovastatin (MEVACOR, Merck & Co, Whitehouse Station, NJ), the first marketed pharmaceutical statin, and is chemically identical to such product...
October 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28579756/effect-of-a-food-supplement-containing-berberine-monacolin-k-hydroxytyrosol-and-coenzyme-q10-on-lipid-levels-a-randomized-double-blind-placebo-controlled-study
#19
Sergio D'Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli, Giuseppe Derosa
PURPOSE: To evaluate the ability of the new food supplement, Body Lipid (BL), containing red yeast rice, berberine, coenzyme Q10 and hydroxytyrosol, to lower the LDL-C in patients with mild-to-moderate hypercholesterolemia and to assess the overall safety profile of the product. METHODS: In this multicenter, randomized, double-blind, placebo and active comparator (the marketed Armolipid Plus(®) [AM]) controlled study, 158 hypercholesterolemic patients were randomized following a 4-week dietary run-in period...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28560168/genome-sequence-of-the-oleaginous-yeast-rhodotorula-toruloides-strain-cgmcc-2-1609
#20
Christine Sambles, Sabine Middelhaufe, Darren Soanes, Dagmara Kolak, Thomas Lux, Karen Moore, Petra Matoušková, David Parker, Rob Lee, John Love, Stephen J Aves
Most eukaryotic oleaginous species are yeasts and among them the basidiomycete red yeast, Rhodotorula (Rhodosporidium) toruloides (Pucciniomycotina) is known to produce high quantities of lipids when grown in nitrogen-limiting media, and has potential for biodiesel production. The genome of the CGMCC 2.1609 strain of this oleaginous red yeast was sequenced using a hybrid of Roche 454 and Illumina technology generating 13 × coverage. The de novo assembly was carried out using MIRA and scaffolded using MAQ and BAMBUS...
September 2017: Genomics Data
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