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https://www.readbyqxmd.com/read/29234845/eanm-guideline-for-radionuclide-therapy-with-radium-223-of-metastatic-castration-resistant-prostate-cancer
#1
Thorsten D Poeppel, Daria Handkiewicz-Junak, Michael Andreeff, Alexander Becherer, Andreas Bockisch, Eva Fricke, Lilli Geworski, Alexander Heinzel, Bernd J Krause, Thomas Krause, Markus Mitterhauser, Wilfried Sonnenschein, Lisa Bodei, Roberto C Delgado-Bolton, Michael Gabriel
Radium Ra-223 dichloride (radium-223, Xofigo®) is a targeted alpha therapy approved for the treatment of castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. Radium-223 is the first targeted alpha therapy in this indication providing a new treatment option, with evidence of a significant survival benefit, both in overall survival and in the time to the first symptomatic skeletal-related event. The skeleton is the most common metastatic site in patients with advanced prostate cancer...
December 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29234738/redesigning-axial-axial-biaxial-cruciform-specimens-for-very-high-cycle-fatigue-ultrasonic-testing-machines
#2
Diogo Montalvão, Andrew Wren
The necessity to increase performances in terms of lifetime and security in mechanical components or structures is the motivation for intense research in fatigue. Applications range from aeronautics to medical devices. With the development of new materials, there is no longer a fatigue limit in the classical sense, where it was accepted that the fatigue limit is the stress level such that there is no fracture up to 1E7 cycles. The recent development of ultrasonic testing machines where frequencies can go as high as 20 kHz or over enabled tests to be extended to ranges larger than 1E9 in just a few days...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29234646/a-retrospective-analysis-of-surgically-treated-complex-proximal-femur-fractures-with-proximal-femoral-locking-compression-plate
#3
Syed Ibrahim, Jimmy Joseph Meleppuram
Objective: Analyze the outcomes of proximal femoral locking compression plate (PF-LCP) in these complex fractures. Methods: This study retrospectively analyzed 21 proximal femoral fractures treated with PF-LCP from June 2013 to February 2015. There were 15 females (71%) and six males (29%) with an average age of 61.4 years (range: 34-80 years). The peritrochanteric fractures constituted by intertrochanteric and subtrochanteric fractures were classified by the Boyd and Griffin classification and Seinshemier's classification, respectively...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234150/the-shallow-structure-of-solfatara-volcano-italy-revealed-by-dense-wide-aperture-seismic-profiling
#4
Pier Paolo G Bruno, Stefano Maraio, Gaetano Festa
Two active-source, high-resolution seismic profiles were acquired in the Solfatara tuff cone in May and November 2014, with dense, wide-aperture arrays. Common Receiver Surface processing was crucial in improving signal-to-noise ratio and reflector continuity. These surveys provide, for the first time, high-resolution seismic images of the Solfatara crater, depicting a ~400 m deep asymmetrical crater filled by volcanoclastic sediments and rocks and carved within an overall non-reflective pre-eruptive basement showing features consistent with the emplacement of shallow intrusive bodies...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233697/retrospective-analysis-of-471-surgically-treated-zygomaticomaxillary-complex-fractures
#5
Michael Blumer, Sabina Kumalic, Thomas Gander, Martin Lanzer, Claudio Rostetter, Martin Rücker, Heinz-Theo Lübbers
PURPOSE: Zygomaticomaxillary complex (ZMC) fractures are frequent in facial trauma; only fractures of the mandible are more common. Although the frequency of these fractures is geographically consistent, the aetiology differs widely among countries and even regions. Differences in socio-economic status and the ageing population seem to be two causes. This retrospective epidemiological study evaluates patients who were surgically treated for ZMC fractures at a Swiss university clinic. MATERIALS AND METHODS: This study included 471 patients who were surgically treated for ZMC fractures in an oral and maxillofacial surgery clinic at a Swiss university hospital between January 2004 and December 2012...
November 23, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29232486/an-essential-warning-editorial-on-vertebral-fractures-after-discontinuation-of-denosumab-a-post-hoc-analysis-of-the-randomized-placebo-controlled-freedom-trial-its-extension
#6
Benjamin Leder
Over the past two decades, osteoporosis treatment options have expanded greatly and physicians and patients are now able to choose among several classes of medications and numerous specific drugs. As these options have grown, however, the choice of which medication to prescribe and how to balance the risks and benefits in specific populations and individual patients has become increasingly complex. This complexity, in turn, combined with the proliferation of well-publicized reports of rare but serious side effects, is exacerbating the recent trend of declining rates of osteoporosis treatment...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29232164/effect-of-ct-on-management-plan-in-malleolar-ankle-fractures
#7
Ashwani Kumar, Puneet Mishra, Anupama Tandon, Rajesh Arora, Manish Chadha
BACKGROUND: Conventionally ankle fractures have been classified using plain radiographs. Because of complex 3-dimensional anatomy and complexity of injuries, plain radiographs may not always be able to clearly depict the complete fracture pattern. There is a paucity of studies regarding the utility of computed tomography (CT) scanning in malleolar ankle fractures (MAFs). Hence, we conducted this study to further understand the role of the CT scan in MAFs. METHODS: A prospective study of 56 consecutive malleolar ankle fractures was conducted...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29230427/biomechanical-comparison-of-single-versus-double-row-capsulolabral-repair-for-shoulder-instability-a-review
#8
REVIEW
Matthew John Yousif, James Bicos
Background: The glenohumeral joint is the most commonly dislocated joint in the body. Failure rates of capsulolabral repair have been reported to be approximately 8%. Recent focus has been on restoration of the capsulolabral complex by a double-row capsulolabral repair technique in an effort to decrease redislocation rates after arthroscopic capsulolabral repair. Purpose: To present a review of the biomechanical literature comparing single- versus double-row capsulolabral repairs and discuss the previous case series of double-row fixation...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29224693/musculoskeletal-health-and-frailty
#9
REVIEW
Fiona E McGuigan, Patrik Bartosch, Kristina E Åkesson
Frailty is a consequence of advanced aging, where the frailty phenotype tries to capture overall decline in health. Frailty involves multiple physiological systems that are intrinsically inter-related and with highly complex interactions. Frailty is closely linked to musculoskeletal health; musculoskeletal functioning is a key component in quantifying frailty, while at the same time, frailty is associated with the most common age-related musculoskeletal conditions: osteoporosis, fractures, falls, osteoarthritis, and spinal conditions...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29219052/adverse-events-of-proton-pump-inhibitors-potential-mechanisms
#10
Andrea Corsonello, Fabrizia Lattanzio, Silvia Bustacchini, Sabrina Garasto, Annalisa Cozza, Roberto Schepisi, Federica Lenci, Filippo Luciani, Marcello Giuseppe Maggio, Andrea Ticinesi, Valeria Butto, Sara Tagliaferri, Francesco Corica
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of proton pump inhibitors (PPIs). METHODS: A Pubmed search was performed, and 207 studies concerning the relationship between use of PPIs and cardiovascular diseases, kidney impairment, nutritional disorders, fractures, infections, functional decline, and mortality were selected and reviewed. RESULTS: PPIs may cause potentially harmful effects by several mechanisms, including endothelial dysfunction, hypomagnesemia, drug interactions, reduced absorption of selected nutrients, increased gastric microbiota and small intestine bacterial overgrowth, reduced immune response, tubular-interstitial inflammation, increased bone turnover, accumulation of amyloid in the brain...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29218382/restrictive-pulmonary-dysfunction-is-associated-with-vertebral-fractures-and-bone-loss-in-elderly-postmenopausal-women
#11
R Watanabe, M Shiraki, M Saito, R Okazaki, D Inoue
Association between lung function and bone metabolism remains controversial. We found that impaired lung function was associated with vertebral fractures and bone loss in Japanese postmenopausal women. While vertebral deformities would impair lung function, respiratory dysfunction might in turn increase fracture risk, suggesting a complex bidirectional interaction. INTRODUCTION: Association between bone metabolism and pulmonary function in the general population is controversial. The aim of this study was to investigate relationship between lung and bone parameters in elderly postmenopausal women...
December 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29217280/photosome-membranes-merge-and-organize-tending-towards-rhombohedral-symmetry-when-light-is-emitted
#12
Malika Ouldali, Virginie Maury, Gisèle Nicolas, Jean Lepault
Polynoid worm elytra emit light when mechanically or electrically stimulated. Specialized cells, the photocytes, contain light emitting machineries, the photosomes. Successive stimulations induce light intensity variations and show a coupling within and between photosomes. Here, we describe, using electron tomography of cryo-substituted elytra and freeze-fracturing, the structural transition associated to light emission: undulating tubules come closer, organize and their number forming photosomes increases...
December 4, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29211029/generalized-fracture-toughness-and-compressive-strength-of-sustainable-concrete-including-low-calcium-fly-ash
#13
Grzegorz Ludwik Golewski
The paper presents the results of tests on the effect of the low calcium fly ash (LCFA) addition, in the amounts of: 0% (LCFA-00), 20% (LCFA-20) and 30% (LCFA-30) by weight of cement, on fracture processes in structural concretes. In the course of the experiments, compressive strength of concrete and fracture toughness for: I (tensile), II (in-plane shear) and III (anti-plane shear) models of cracking were measured. The tests determined the effect of age of concretes modified with LCFA on the analyzed parameters...
December 6, 2017: Materials
https://www.readbyqxmd.com/read/29209809/reduction-and-temporary-stabilization-of-tile-c-pelvic-ring-injuries-using-a-posteriorly-based-external-fixation-system
#14
Murphy P Martin, David Rojas, Cyril Mauffrey
Tile C pelvic ring injuries are challenging to manage even in the most experienced hands. The majority of such injuries can be managed using percutaneous reduction techniques, and the posterior ring can be stabilized using percutaneous transiliac-transsacral screw fixation. However, a subgroup of patients present with inadequate bony corridors, significant sacral zone 2 comminution or significant lateral/vertical displacement of the hemipelvis through a complete sacral fracture. Percutaneous strategies in such circumstances can be dangerous...
December 5, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29207845/two-episodes-of-trigeminocardiac-reflex-during-a-pan-facial-fracture-surgery-a-rare-phenomenon-case-report-and-review-of-literature
#15
Abhishek Bhattacharjee, Prashanth Rajaram, Abhishek Khatua, K B Rudresh, Pallavi B Krishnamurthy
Trigeminocardiac reflex is a sudden physiologic response due to mechanical manipulation of any of the branches of trigeminal nerve. Trigeminocardiac reflex occurs due to pressure effect or stretching of trigeminal nerve which causes fall in blood pressure and decrease in heart rate. In this reflex arc, the trigeminal nerve serves as afferent pathway and vagus nerve, which is cardio inhibitory in nature, serves as efferent pathway. Two episodes of trigeminocardiac reflex during maxillofacial trauma surgery is not a common phenomenon...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207793/posterior-dislocation-of-subtalar-joint-without-associated-fracture-a-case-report-and-review-of-literature
#16
Sahil Gaba, Arvind Kumar, Vivek Trikha, Saubhik Das, Prabhat Agrawal
Posterior subtalar dislocation is an exceedingly rare entity. Clinically, the appearance of the foot can simulate a complex fracture dislocation. It is important to recognize that not all posterior subtalar dislocations are true posterior dislocations. We report a true posterior subtalar dislocation in a 34-year-old female, managed promptly with closed reduction and resulting in an excellent functional outcome. A chronic dislocation or an irreducible dislocation may need open reduction.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207307/systemic-sclerosis-clinical-manifestations-anesthetic-and-orthopedic-considerations-in-a-patient
#17
Obada Hasan, Muneeba Jessar, Muhammad Ashar, Shahryar Noordin, Tashfeen Ahmad
INTRODUCTION: Systemic sclerosis is a rare and progressive multisystem autoimmune disorder that is characterized pathologically by vascular abnormalities, connective tissue sclerosis and atrophy of skin and various internal organs (e.g., alimentary tract, lungs, heart, kidney, CNS), and autoantibodies. With an unknown etiology, Scleroderma is a complex polygenetic disease. A recent Genome Wide Association Study (GWAS) confirmed a strong association with the Major Histocompatibility Complex (MHC) and autoimmunity...
December 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29207216/the-roles-of-cellular-and-molecular-components-of-a-hematoma-at-early-stage-of-bone-healing
#18
REVIEW
Hoi Ting Shiu, Ping Chung Leung, Chun Hay Ko
Bone healing is a complex repair process which commences with formation of a blood clot at the injured bone, termed hematoma. It has evidenced that a lack of a stable hematoma causes delayed bone healing or non-union. The hematoma at the injured bone constitutes the early healing microenvironment. It appears to dictate healing pathways which ends in a regenerative bone. However, the hematoma is often clinically removed from the damaged site. Conversely, blood-derived products have been used in bone tissue engineering for treating critical sized defects (CSDs), including fibrin gels and platelet rich plasma...
December 5, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29205071/impact-of-helmet-use-in-equestrian-related-traumatic-brain-injury-a-matched-pairs-analysis
#19
Georg Bier, Malte N Bongers, Ahmed Othman, Johann-Martin Hempel, Volker Vieth, Walter Heindel, Ulrike Ernemann, Matthias C Burg
PURPOSE: Traumatic brain injury is an important health concern in equestrian sports. Nevertheless, the use of safety helmets, especially in recreational riding, is reported to be rare. The purpose of this study was to perform the first matched-pairs analysis of traumatic brain injury with regard to the use of helmets. MATERIALS AND METHODS: In a multicenter retrospective database analysis 40 patients (mean age: 35 ± 17.13 years; 34 female & 6 male) were combined in 20 matched pairs based on age group, gender and trauma mechanism...
December 5, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29204486/fracture-of-the-femoral-adapter-bolt-and-taper-adapter-in-a-modern-rotating-platform-knee-arthroplasty
#20
Elexis C Baral, Alexander S McLawhorn, Timothy M Wright, Edwin P Su
A 58-year-old woman presented with onset of pain associated with a popping sound after a twisting motion 4 years after left total knee revision arthroplasty. She had a complex medical history, including a reported bone cement allergy, and presented to the hospital unable to bear weight. Plain radiographs revealed a broken femoral component, with the femoral metaphyseal sleeve separated from the distal articular component. During surgery, it was observed that the femoral adapter bolt and taper adapter had both fractured...
December 2017: Arthroplasty Today
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