keyword
https://read.qxmd.com/read/38380687/long-term-post-transplantation-outcomes-in-patients-with-hypertrophic-cardiomyopathy-single-center-35-year-experience
#21
JOURNAL ARTICLE
Matylda Mazur, Geetha Bhat, Eric Popjes, Robert Dowling, Howard J Eisen
BACKGROUND: Heart transplantation (HT) is the only option for most patients with end-stage heart failure and hypertrophic cardiomyopathy (HCM) who fail medical therapy. Data on the long-term outcomes post-transplant in HCM individuals remain scarce. METHODS: We analyzed data of 319 adult patients who underwent HT between 1984 and 2019. Patients were followed for cardiac allograft rejection, cardiac allograft vasculopathy (CAV), death, or re-transplantation. RESULTS: Outcomes of 24 patients with HCM, 160 with ischemic, and 135 with dilated cardiomyopathy were compared...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38380175/a-gentler-approach-to-monitor-for-heart-transplant-rejection
#22
REVIEW
Jason F Goldberg, Aditya Mehta, Rupinder K Bahniwal, Sean Agbor-Enoh, Palak Shah
Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy. Increasing evidence shows the utility of molecular evaluations, such as donor-specific antibodies and donor-derived cell-free DNA, as well as advanced imaging techniques, such as cardiac magnetic resonance imaging, in the assessment of rejection, resulting in the elimination of many surveillance endomyocardial biopsies...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38369851/using-hcv-viremic-organs-for-lung-transplantation-does-not-confer-higher-rejection-rates-compared-to-hcv-negative-organs
#23
JOURNAL ARTICLE
Kamyar Afshar, Elizabeth Schonhoft, Jade Kozuch, Aarya Kafi, Gordon Yung, Travis Pollema, Eugene Golts, Saima Aslam
BACKGROUND: National data demonstrate that hepatitis C virus (HCV)-infected organ donors are increasingly being used in the US, including for lung transplantation. We aimed to assess whether there were any differences in the acute or chronic rejection rates at 1 year following lung transplantation from HCV-viremic versus uninfected donors. METHODS: We retrospectively reviewed all lung transplant recipients at our institution from April 1, 2017 to October 1, 2020 and then assessed various outcomes between those who received a transplant from HCV-viremic donors versus HCV-negative donors...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38340315/advances-in-injectable-hydrogels-for-radiation-induced-heart-disease
#24
JOURNAL ARTICLE
Lu-Yao Zhao, Xin-Yue Wang, Mei-Ling Wen, Ning-Ning Pan, Xing-Qi Yin, Mei-Wen An, Li Wang, Yang Liu, Jian-Bo Song
Radiological heart damage (RIHD) is damage caused by unavoidable irradiation of the heart during chest radiotherapy, with a long latency period and a progressively increasing proportion of delayed cardiac damage due to conventional doses of chest radiotherapy. There is a risk of inducing diseases such as acute/chronic pericarditis, myocarditis, delayed myocardial fibrosis and damage to the cardiac conduction system in humans, which can lead to myocardial infarction or even death in severe cases. This paper details the pathogenesis of RIHD and gives potential targets for treatment at the molecular and cellular level, avoiding the drawbacks of high invasiveness and immune rejection due to drug therapy, medical device implantation and heart transplantation...
February 10, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38338013/treatment-of-equine-tarsus-long-medial-collateral-ligament-desmitis-with-allogenic-synovial-membrane-mesenchymal-stem-stromal-cells-enhanced-by-umbilical-cord-mesenchymal-stem-stromal-cell-derived-conditioned-medium-proof-of-concept
#25
JOURNAL ARTICLE
Inês Leal Reis, Bruna Lopes, Patrícia Sousa, Ana Catarina Sousa, Mariana V Branquinho, Ana Rita Caseiro, Alexandra Rêma, Inês Briote, Carla M Mendonça, Jorge Miguel Santos, Luís M Atayde, Rui D Alvites, Ana Colette Maurício
Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used to develop therapeutic products, as they secrete a variety of bioactive molecules that play a pivotal role in tissue regeneration...
January 24, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38325525/three-year-outcomes-of-de-novo-tacrolimus-extended-release-tablets-lcpt-compared-to-twice-daily-tacrolimus-in-adult-heart-transplantation
#26
JOURNAL ARTICLE
Amit Alam, Johanna S van Zyl, Raksha Patel, Aayla K Jamil, Joost Felius, Sandra A Carey, Robert L Gottlieb, Cesar Y Guerrero-Miranda, Parag Kale, Shelley A Hall, Teena Sam
BACKGROUND: Extended-release tacrolimus for prophylaxis of allograft rejection in heart transplant (HT) recipients is currently not FDA-approved. One such extended-release formulation of tacrolimus known as LCPT allows once-daily dosing and improves bioavailability compared to immediate-release (IR-) tacrolimus. We compared long-term efficacy and safety of LCPT to IR-tacrolimus applied de novo in adult OHT recipients. METHODS: 25 prospective recipients on LCPT at our center from 2017 to 2019 were matched 1:2 with historical control recipients treated with IR-tacrolimus based on age, gender, and baseline creatinine...
February 5, 2024: Transplant Immunology
https://read.qxmd.com/read/38311391/-kidney-transplantation-for-end-stage-renal-disease-after-third-allogeneic-hematopoietic-stem-cell-transplantation-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#27
JOURNAL ARTICLE
Akihiko Nishijima, Naoki Shingai, Akihito Ohta, Kiyoko Suda, Kazuya Omoto, Shinya Ishida, Kosuke Yoshioka, Shuhei Kurosawa, Yutaro Hino, Yasushi Senoo, Aiko Igarashi, Gaku Oshikawa, Atsushi Hamamura, Takashi Toya, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Kyoko Haraguchi, Yoshiki Okuyama, Kazuteru Ohashi, Noriko Doki
An 18-year-old man underwent allogenic bone marrow transplantation (BMT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). Ph+ALL relapsed 3 months after the first BMT, and the patient underwent a second BMT. However, Ph+ALL relapsed 4 months after the second BMT, and he received a haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) from his father. Molecular complete remission was confirmed 29 days after haplo-PBSCT. However, the patient needed dialysis for end-stage renal disease due to thrombotic microangiopathy 3 years and 2 months after haplo-PBSCT...
2024: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/38304826/qualification-of-a-flow-cytometry-based-method-for-the-evaluation-of-in-vitro-cytotoxicity-of-gta002-natural-killer-cell-therapy
#28
JOURNAL ARTICLE
Monica Raimo, Alexandra G Zavoianu, Wilma Meijs, Pascal Scholten, Jan Spanholtz
BACKGROUND: Natural Killer (NK) cell-based therapies represent a ground-breaking opportunity for the treatment of solid tumors and hematological malignancies. NK cell manufacturing under good manufacturing practice (GMP) is complex and requires attentive assessment the product's safety and efficacy through quality control (QC). Release testing includes monitoring of in vitro cell expansion, differentiation, purity, phenotype, and cytotoxicity. As NK cells are biologically active products, the establishment of potency methods is particularly relevant; surrogate or improper assays can lead to rejection of qualifiable batches or to release of products that falsely meet potency specifications, potentially causing low efficacy during clinical trials...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38294834/a-biomimetic-multifunctional-nanoframework-for-symptom-relief-and-restorative-treatment-of-acute-liver-failure
#29
JOURNAL ARTICLE
Ruibing Feng, Yu Fan, Xinya Zhang, Lanmei Chen, Zhang-Feng Zhong, Yitao Wang, Hua Yu, Qing-Wen Zhang, Guodong Li
Acute liver failure (ALF) is a rare and serious condition characterized by major hepatocyte death and liver dysfunction. Owing to the limited therapeutic options, this disease generally has a poor prognosis and a high mortality rate. When ALF cannot be reversed by medications, liver transplantation is often needed. However, transplant rejection and the shortage of donor organs still remain major challenges. Most recently, stem cell therapy has emerged as a promising alternative for the treatment of liver diseases...
January 31, 2024: ACS Nano
https://read.qxmd.com/read/38288651/reaching-new-heights-a-comprehensive-study-of-hand-transplantations-in-korea-after-institutionalization-of-hand-transplantation-law
#30
JOURNAL ARTICLE
Yo Han Kim, Yun Rak Choi, Dong Jin Joo, Woo Yeol Baek, Young Chul Suh, Won Taek Oh, Jae Yong Cho, Sang Chul Lee, Sang Kyum Kim, Hyang Joo Ryu, Kyung Ock Jeon, Won Jai Lee, Jong Won Hong
PURPOSE: With the revision of the Organ and Transplantation Act in 2018, the hand has become legal as an area of transplantable organs in Korea. In January 2021, the first hand allotransplantation since legalization was successfully performed, and we have performed a total of three successful hand transplantation since then. By comparing and incorporating our experiences, this study aimed to provide a comprehensive reconstructive solution for hand amputation in Korea. MATERIALS AND METHODS: Recipients were selected through a structured preoperative evaluation, and hand transplantations were performed at the distal forearm level...
February 2024: Yonsei Medical Journal
https://read.qxmd.com/read/38283705/abo-incompatible-living-donor-liver-transplantation-in-children-a-single-centre-experience-from-india
#31
JOURNAL ARTICLE
Vipul Gautam, Vikram Kumar, Shaleen Agarwal, Subhash Gupta
BACKGROUND: In recent years, paediatric ABO incompatible (ABOi) living donor liver transplant (LT) has shown promising outcomes and can potentially eliminate organ shortage. This study aims to report paediatric ABOi LT experience, including short- and long-term outcomes. METHODS: It is a single-centre retrospective study. Out of 108 LTs, 20 were done in children. We compared the outcomes between ABOi (n = 20) and non-ABOi (n = 220) paediatric living donor liver transplantation (LDLT) performed during the study period...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38279485/galectin-9-contributes-to-the-survival-of-fully-allogeneic-skin-grafts-by-modulating-effector-t-cells-and-tregs-imbalance
#32
JOURNAL ARTICLE
Yu Luo, Bingyi Shi, Yeyong Qian, Hongwei Bai, Feng Liu
Allogeneic skin transplantation is an important clinical treatment for many diseases. Although Galectin-9 demonstrates multifaceted roles in modulating immune cell homeostasis and inflammation, its precise impact on balancing effector T cells and Tregs during allogeneic skin transplantation remains uncertain. This work was performed to evaluate the modulation of the survival time of allogeneic skin grafts by Gal-9 and to explore the critical mechanism involved in this process. Skin graft transplantation was conducted using C57BL/6 and BALB/c mice...
December 31, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38271682/experience-with-pembrolizumab-in-a-renal-transplant-patient-with-advanced-lung-cancer-a-case-report-and-review
#33
JOURNAL ARTICLE
Laura Fernández Madrigal, Victoria García Samblásand, Laura Sánchez Escudero
The treatment of non-small cell lung cancer (NSCLC) has undergone a change due to the advancement of new therapies, like immune checkpoint inhibitors (ICIs), including pembrolizumab. A 64-year-old woman received a kidney transplant in 2012 due to chronic kidney disease secondary to glomerulosclerosis, diagnosed in 2020 with stage IV NSCLC due to metastasis in the contralateral lung, with PD-L1 expression of 98%, starting treatment with ICIs, despite presenting a graft rejection risk around 40%. After 3 ICI cycles, the patient presented a partial response, with good tolerance to treatment and no signs of graft failure...
January 23, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38269612/kidney-transplantation-in-patients-on-anti-tubercular-therapy-a-single-centre-observational-study
#34
JOURNAL ARTICLE
Pallavi Prasad, Sahil Bagai, Vandana Prasad, Rahul Grover, Gagandeep Chhabra, Dinesh Khullar
BACKGROUND: Tuberculosis (TB) is a common infection in chronic kidney disease. The prolonged therapy of TB can delay kidney transplantation in patients on antitubercular therapy (ATT). METHODS: This was a retrospective single-center study to analyze the safety of kidney transplantation and its outcomes in patients undergoing transplantation while on the continuation phase of ATT. RESULTS: Between 2013 and 2022, 30 patients underwent kidney transplantation while on ATT...
January 25, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/38256691/heart-transplantation
#35
REVIEW
Nikolaos Chrysakis, Dimitrios E Magouliotis, Kyriakos Spiliopoulos, Thanos Athanasiou, Alexandros Briasoulis, Filippos Triposkiadis, John Skoularigis, Andrew Xanthopoulos
Heart transplantation (HTx) remains the last therapeutic resort for patients with advanced heart failure. The present work is a clinically focused review discussing current issues in heart transplantation. Several factors have been associated with the outcome of HTx, such as ABO and HLA compatibility, graft size, ischemic time, age, infections, and the cause of death, as well as imaging and laboratory tests. In 2018, UNOS changed the organ allocation policy for HTx. The aim of this change was to prioritize patients with a more severe clinical condition resulting in a reduction in mortality of people on the waiting list...
January 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38256619/interpretation-of-ldh-values-after-kidney-transplantation
#36
JOURNAL ARTICLE
Zoltán Sándor, Dorottya Katics, Ádám Varga, Károly Kalmár Nagy, Péter Szakály
Kidney transplantation is the gold-standard therapy for end-stage renal disease. However, in the early postoperative period following allograft kidney transplantation, insufficient graft function presents a diagnostic challenge to clinicians. Ischemic damage to the graft and/or an early autoimmune rejection may cause a decrease in function. Ischemic damage is a benign and transient condition, while acute immune rejection requires immediate therapy. A kidney graft ultrasound may produce a false negative result, and graft biopsy is invasive and slow to return results...
January 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38248753/rejection-requiring-treatment-within-the-first-year-following-heart-transplantation-the-unos-insight
#37
JOURNAL ARTICLE
Marco Gemelli, Ilias P Doulamis, Aspasia Tzani, Athanasios Rempakos, Polydoros Kampaktsis, Paulino Alvarez, Alvise Guariento, Andrew Xanthopoulos, Grigorios Giamouzis, Kyriakos Spiliopoulos, Rabea Asleh, Ernesto Ruiz Duque, Alexandros Briasoulis
(1) Background: Heart failure is an extremely impactful health issue from both a social and quality-of-life point of view and the rate of patients with this condition is destined to rise in the next few years. Transplantation remains the mainstay of treatment for end-stage heart failure, but a shortage of organs represents a significant problem that prolongs time spent on the waiting list. In view of this, the selection of donor and recipient must be extremely meticulous, considering all factors that could predispose to organ failure...
December 29, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38248320/recent-advances-in-liver-tissue-engineering-as-an-alternative-and-complementary-approach-for-liver-transplantation
#38
REVIEW
Dileep G Nair, Ralf Weiskirchen
Acute and chronic liver diseases cause significant morbidity and mortality worldwide, affecting millions of people. Liver transplantation is the primary intervention method, replacing a non-functional liver with a functional one. However, the field of liver transplantation faces challenges such as donor shortage, postoperative complications, immune rejection, and ethical problems. Consequently, there is an urgent need for alternative therapies that can complement traditional transplantation or serve as an alternative method...
December 29, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/38247571/immune-responses-to-anti-hepatitis-c-virus-antibodies-during-pre-liver-transplantation-direct-acting-antiviral-therapy-in-hepatitis-c-virus-infected-recipients-associated-with-post-liver-transplantation-allograft-injury
#39
JOURNAL ARTICLE
Shu-Hsien Lin, Kun-Ta Wu, Chih-Chi Wang, Kuang-Tzu Huang, Li-Wen Hsu, Hock-Liew Eng, King-Wah Chiu
BACKGROUND AND AIMS: The impact of antibody responses following direct-acting antiviral (DAA) therapy in hepatitis C virus (HCV)-infected recipients before and after liver transplantation (LT) is still undetermined. METHODS: In this observational cohort study, we aimed to explore the association between changes in anti-HCV antibody titers following pre-LT DAA therapy and allograft injury, including biliary complications (BCs) and acute cellular rejection (ACR). RESULTS: A total of 153 cases were enrolled from January 2015 to February 2021...
January 16, 2024: Antibodies
https://read.qxmd.com/read/38237243/mirna-as-potential-biomarkers-after-liver-transplantation-a-systematic-review
#40
REVIEW
Pia F Koch, Kristina Ludwig, Felix Krenzien, Karl H Hillebrandt, Wenzel Schöning, Johann Pratschke, Nathanael Raschzok, Igor M Sauer, Simon Moosburner
BACKGROUND: Liver transplantation is a life-saving therapy for end-stage liver disease patients, but acute cellular rejection (ACR) and graft complications remain significant postoperative challenges. Early and accurate diagnosis is crucial for timely intervention and improved patient outcomes, but their diagnosis rely currently on invasive biopsy sampling, thus prompting the search for non-invasive Biomarkers. MicroRNA (miRNA) have emerged as promising biomarkers in various pathological conditions, and their potential utility in diagnosing acute cellular rejection after liver transplantation has gained significant interest...
January 14, 2024: Transplantation Reviews
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