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isolated hypothyroxinemia

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https://www.readbyqxmd.com/read/27760478/prevalence-of-hypothyroidism-during-pregnancy-in-a-highly-specialised-referral-centre-in-mexico
#1
Eunice López-Muñoz, Jorge Antonio Ibarra-Avalos, Rosario Guadalupe Chan-Verdugo, Leovigildo Mateos-Sánchez, Olivia Sánchez-Rodríguez
In order to determine the prevalence of overt and subclinical hypothyroidism, and isolated hypothyroxinemia during pregnancy, thyroid hormone reference values established by UMAE HGO4, IMSS in Mexico City and those suggested by the American Thyroid Association (ATA) were used. All pregnant patients, whose thyroid function was measured and whose pregnancy was monitored and resolved in UMAE HGO4, IMSS from 1 January to 31 December 2013, were included. Significant differences (p = .00419) were observed in the frequency of subclinical hypothyroidism, being higher when using ATA criteria (18...
October 20, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27528503/management-of-endocrine-disease-isolated-maternal-hypothyroxinemia-during-pregnancy-knowns-and-unknowns
#2
Chrysoula Dosiou, Marco Medici
Isolated maternal hypothyroxinemia (IMH) during pregnancy is defined as a low maternal T4 in the absence of TSH elevation. As IMH is common, with a prevalence of 1-2% in iodine-sufficient populations, and early research has suggested adverse effects on fetal neurodevelopment, it has been the focus of many studies in the last decade. In the current review, we first discuss the significance of IMH based on data from animal models and recent discoveries regarding the role of thyroid hormone on neurodevelopment...
August 15, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27175703/the-effect-of-subclinical-maternal-thyroid-dysfunction-and-autoimmunity-on-intrauterine-growth-restriction-a-systematic-review-and-meta-analysis
#3
Zhao Tong, Zhang Xiaowen, Chen Baomin, Liu Aihua, Zhou Yingying, Teng Weiping, Shan Zhongyan
The objective of this study was to evaluate the association between maternal subclinical thyroid dysfunction and autoimmunity with the risk for intrauterine growth restriction (IUGR).Design is a systematic review and meta-analysis.A literature search was conducted using PubMed, Embase, and Cochrane database. A combination of 2 key words was used to search for the eligible studies: one indexed thyroid dysfunction or antithyroid antibodies; and the other one indexed the adverse neonatal outcomes of pregnancy, such as IUGR, small for gestational age, fetal growth restriction, or low birth weight...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27114049/thyroid-function-in-patients-with-cystic-fibrosis-no-longer-a-concern
#4
Sun Y Lee, Supavit Chesdachai, Moon J Lee, Xue-Mei He, Vin Tangpricha, Lewis E Braverman
BACKGROUND: Development of goiter and hypothyroidism has been reported in patients with cystic fibrosis (CF) since the 1970s, especially when treated with iodine-based expectorants. With iodine-containing expectorants no longer in routine use, the prevalence of thyroid dysfunction in CF patients is unknown. This cross-sectional study assessed thyroid function status in a large cohort of CF patients. METHODS: Sera from ambulatory subjects were obtained from an Institutional Review Board (IRB)-approved biorepository of patients seen at the Emory CF Center between January 1, 2011, and December 31, 2014...
July 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26383905/maternal-thyroid-disease-and-preterm-birth-systematic-review-and-meta-analysis
#5
REVIEW
Penelope M Sheehan, Alison Nankervis, Edward Araujo Júnior, Fabricio Da Silva Costa
CONTEXT: Thyroid disease in pregnancy is increasing with rising average maternal ages in developed countries. The evidence for an association between preterm birth and thyroid disease has been confounded by small studies with varying outcomes and methodology. OBJECTIVE: The aim of this meta-analysis is to review the literature regarding thyroid disease including subclinical and overt hypothyroidism, hyperthyroidism, and isolated hypothyroxinemia and the specific outcome of preterm birth...
November 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26273610/high-body-mass-index-is-an-indicator-of-maternal-hypothyroidism-hypothyroxinemia-and-thyroid-peroxidase-antibody-positivity-during-early-pregnancy
#6
Cheng Han, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Xiaomei Zhang, Liu Yang, Chenling Fan, Weiping Teng, Zhongyan Shan
BACKGROUND: Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the American Thyroid Association recommended screening thyroid function in obese pregnant women; however, the evidence for this is weak. For this purpose, our study investigated the relationship between high BMI and thyroid functions during early pregnancy in Liaoning province, an iodine-sufficient region of China...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26204137/placental-angiogenic-factors-are-associated-with-maternal-thyroid-function-and-modify-hcg-mediated-ft4-stimulation
#7
Tim I M Korevaar, Eric A P Steegers, Yolanda B de Rijke, W Edward Visser, Vincent W V Jaddoe, Theo J Visser, Marco Medici, Robin P Peeters
CONTEXT: The thyroid has a high vascular density and this vascularity may be influenced by pregnancy-specific angiogenic factors. Proangiogenic placental growth factor (PlGF) and antiangiogenic soluble FMS-like tyrosine kinase-1 (sFlt1; a vascular endothelial growth factor [VEGF] and PlGF antagonist) are important pregnancy-specific angiogenesis regulators. We previously showed that fetal levels of sFlt1 and PlGF are associated with newborn thyroid function. However, the maternal thyroid may also be affected as PlGF and VEGF are secreted into the maternal circulation and cause a concomitant increase of sFlt1 to overcome adverse effects of angiogenesis overstimulation...
October 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26190538/frequency-of-isolated-maternal-hypothyroxinemia-in-women-with-gestational-diabetes-mellitus-in-a-moderately-iodine-deficient-area
#8
Ayten Oguz, Dilek Tuzun, Murat Sahin, Alper Celil Usluogullari, Betül Usluogullari, Ahmet Celik, Kamile Gul
AIM: To investigate frequency of isolated maternal hypothyroxinemia (IMH) in women with gestational diabetes mellitus (GDM) using both the method specific trimester range (MSTR) and the standard reference range (SRR). METHODS: Our study included 50 GDM patients (case group) and 60 non-GDM pregnant (control group). Glucose, insulin, HOMA-IR, fT4 and TSH values were measured when pregnancy was confirmed in all participants. Thyroid function tests were measured in each trimester using the SRR and the MSTR...
October 2015: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26004887/normal-intellectual-development-in-children-born-from-women-with-hypothyroxinemia-during-their-pregnancy
#9
Gema Grau, Anibal Aguayo, Amaia Vela, Angeles Aniel-Quiroga, Mercedes Espada, Gorka Miranda, Lorea Martinez-Indart, Pedro Martul, Luis Castaño, Itxaso Rica
Proper maternal thyroid function is known to be essential for neural differentiation and migration in the fetus during the first half of pregnancy. The objectives of this study were to assess the relationship between thyroxin levels, in pregnant women with no thyroid disease and the intellectual development of their offspring in a non-iodine-deficient area, and to know specifically whether or not isolated hypothyroxinemia during pregnancy was associated with a lower intelligence in the offspring. Previously we had publicated values TSH, FT4, free T3 (FT3), anti-thyroid peroxidase antibodies (TPO Abs) and urinary iodine concentration (UIC) in 1322 pregnant women in our hospital area...
2015: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/25885104/thyroid-diseases-during-pregnancy-a-number-of-important-issues
#10
REVIEW
Gerasimos Krassas, Spyridon N Karras, Nikolaos Pontikides
The most common thyroid diseases during pregnancy are hyper- and hypothyroidism and their variants including isolated hypothyroxinemia (hypo-T4), autoimmune thyroid disease (AITD) and different types of goiter. AITD represents the main cause of hypothyroidism during pregnancy ranging in prevalence between 5 and 20% with an average of 7.8%. The incidence of isolated hypo-T4 is about 150 times higher compared to congenital hypothyroidism. Prevalence of Graves' disease (GD) ranges between 0.1% and 1% and the Transient Gestational Hyperthyroidism Syndrome between 1 and 3%...
January 2015: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25745488/thyroid-function-in-pregnancy-and-its-influences-on-maternal-and-fetal-outcomes
#11
Forough Saki, Mohammad Hossein Dabbaghmanesh, Seyede Zahra Ghaemi, Sedighe Forouhari, Gholamhossein Ranjbar Omrani, Marzieh Bakhshayeshkaram
BACKGROUND: Maternal thyroid function alters during pregnancy. Inadequate adaptation to these changes results in thyroid dysfunction and pregnancy complications. OBJECTIVES: This prospective study aimed to evaluate the prevalence of thyroid diseases in pregnancy and its outcomes in south of Iran. MATERIALS AND METHODS: This prospective study was conducted on 600 healthy singleton pregnant women who aged 18 to 35 years old at 15 to 28 weeks of gestation...
October 2014: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25629356/optimal-and-safe-upper-limits-of-iodine-intake-for-early-pregnancy-in-iodine-sufficient-regions-a-cross-sectional-study-of-7190-pregnant-women-in-china
#12
Xiaoguang Shi, Cheng Han, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Chenyang Li, Bin Xu, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Xiaomei Zhang, Chenling Fan, Zhongyan Shan, Weiping Teng
CONTEXT: The WHO Technical Consultation recommends urinary iodine concentrations (UIC) from 250 to 499 μg/L as more-than-adequate iodine intake and UIC ≥ 500 μg/L as excessive iodine for pregnant and lactating women, but scientific evidence for this is weak. OBJECTIVE: We investigated optimal and safe ranges of iodine intake during early pregnancy in an iodine-sufficient region of China. METHOD: Seven thousand one hundred ninety pregnant women at 4-8 weeks gestation were investigated and their UIC, serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and thyroglobulin (Tg) were measured...
April 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25599388/iron-deficiency-an-independent-risk-factor-for-isolated-hypothyroxinemia-in-pregnant-and-nonpregnant-women-of-childbearing-age-in-china
#13
Xiaohui Yu, Zhongyan Shan, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Aihua Liu, Xiaochun Teng, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Xiaomei Zhang, Liu Yang, Chenling Fan, Weiping Teng
CONTEXT: Isolated hypothyroxinemia during early pregnancy may irreversibly damage the neurodevelopment of offspring. However, the causes are not well clarified. OBJECTIVE: To explore the association of iron deficiency (ID) with hypothyroid function of women in early pregnancy and nonpregnant women. DESIGN: A total of 7953 pregnant women of ≤ 12 weeks gestation and 2000 childbearing-aged women were recruited. A subpopulation including 3340 pregnant women and 1052 nonpregnant women with sufficient iodine intake and negative thyroid peroxidase antibody were studied...
April 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25433782/-thyroid-dysfunction-during-pregnancy
#14
REVIEW
Juan J Díez, Pedro Iglesias, Sergio Donnay
Recent clinical practice guidelines on thyroid dysfunction and pregnancy have changed health care provided to pregnant women, although their recommendations are under constant revision. Trimester- and area-specific reference ranges for serum thyroid-stimulating hormone are required for proper diagnosis of hypothyroidism and hyperthyroidism. There is no doubt on the need of therapy for overt hypothyroidism, while therapy for subclinical hypothyroidism is controversial. Further research is needed to settle adverse effects of isolated hypothyroxinemia and thyroid autoimmunity...
October 21, 2015: Medicina Clínica
https://www.readbyqxmd.com/read/25370910/update-on-a-new-controversy-in-endocrinology-isolated-maternal-hypothyroxinemia
#15
REVIEW
R M Furnica, J H Lazarus, D Gruson, C Daumerie
Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH. The etiology of IH remains unknown. This review aims to evaluate the biochemical criteria used to define IH in different published studies and to discuss potential maternal as well as fetal outcomes and whether treatment during early pregnancy can prevent the eventual adverse effects. For the current literature a better standardization of free thyroxine assays is needed, as well as the use of appropriated trimester-specific reference intervals for thyroid function tests...
February 2015: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/24240022/failure-of-thyroid-hormone-treatment-to-prevent-inflammation-induced-white-matter-injury-in-the-immature-brain
#16
Anne-Laure Schang, Juliette Van Steenwinckel, Didier Chevenne, Marten Alkmark, Henrik Hagberg, Pierre Gressens, Bobbi Fleiss
Preterm birth is very strongly associated with maternal/foetal inflammation and leads to permanent neurological deficits. These deficits correlate with the severity of white matter injury, including maturational arrest of oligodendrocytes and hypomyelination. Preterm birth and exposure to inflammation causes hypothyroxinemia. As such, supplementation with thyroxine (T4) seems a good candidate therapy for reducing white matter damage in preterm infants as oligodendrocyte maturation and myelination is regulated by thyroid hormones...
March 2014: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/24217906/five-year-follow-up-for-women-with-subclinical-hypothyroidism-in-pregnancy
#17
Beverley M Shields, Bridget A Knight, Anita V Hill, Andrew T Hattersley, Bijay Vaidya
CONTEXT: Increasing numbers of women are being treated with l-thyroxine in pregnancy for mild thyroid dysfunction because of its association with impaired neuropsychological development in their offspring and other adverse obstetric outcomes. However, there are limited data to indicate whether treatment should be continued outside of pregnancy. OBJECTIVES: We aimed to determine whether subclinical hypothyroidism and maternal hypothyroxinemia resolve postdelivery...
December 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23957235/high-prevalence-of-thyroid-dysfunction-among-pregnant-women-in-lubumbashi-democratic-republic-of-congo
#18
Laurence Habimana, Kabange E Twite, Chantal Daumerie, Pierre Wallemacq, Philippe Donnen, Muenze K Kalenga, Annie Robert
BACKGROUND: Despite notable progress in the fight against iodine deficiency disorders in the Democratic Republic of Congo, a recent study has shown that pregnant women in Lubumbashi were still iodine deficient. Our objective was to assess thyroid function in this population. METHODS: In a cross-sectional study conducted in maternity units from three different socioeconomic areas in Lubumbashi, serum thyrotropin, free thyroxine, thyroglobulin, and thyroperoxidase antibodies were measured in 225 pregnant women attending antenatal visits, in 75 women who recently delivered, and in 75 nonpregnant controls...
March 2014: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/23762776/screening-for-maternal-thyroid-dysfunction-in-pregnancy-a-review-of-the-clinical-evidence-and-current-guidelines
#19
Donny L F Chang, Elizabeth N Pearce
Observational studies have demonstrated that maternal thyroid dysfunction and thyroid autoimmunity in pregnancy may be associated with adverse obstetric and fetal outcomes. Treatment of overt maternal hyperthyroidism and overt hypothyroidism clearly improves outcomes. To date there is limited evidence that levothyroxine treatment of pregnant women with subclinical hypothyroidism, isolated hypothyroxinemia, or thyroid autoimmunity is beneficial. Therefore, there is ongoing debate regarding the need for universal screening for thyroid dysfunction during pregnancy...
2013: Journal of Thyroid Research
https://www.readbyqxmd.com/read/23095459/high-prevalence-of-thyroid-dysfunction-in-pregnant-women
#20
M Altomare, S La Vignera, P Asero, D Recupero, R A Condorelli, P Scollo, A Gulisano, E Magro, D Tumino, S Tumino, E Vicari, V Leanza, R D'Agata, A E Calogero
BACKGROUND/AIM: Maternal thyroid dysfunction during pregnancy has been associated with adverse obstetric and neonatal outcomes. This prospective study evaluates the prevalence of these disorders in pregnant women. SUBJECTS AND METHODS: Serum levels of TSH, free T4 (fT4), and thyroperoxidase antibodies (TPO-Ab) were measured in 951 women at different gestational ages of pregnancy. Trimester-specific reference ranges for TSH were used to classify pregnant women into five groups: 1) Overt hypothyroidism (OH); 2) Subclinical hypothyroidism (SCH); 3) Isolated hypothyroxinemia (IH); 4) Low TSH (isolated or associated with high fT4); and 5) Normal...
June 2013: Journal of Endocrinological Investigation
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