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https://www.readbyqxmd.com/read/29052469/vitamin-d-and-l-isoleucine-promote-antimicrobial-peptide-hbd-2-production-in-peripheral-blood-mononuclear-cells-from-elderly-individuals
#1
Julio E Castañeda-Delgado, Zajda Araujo, Irma Gonzalez-Curiel, Carmen J Serrano, Cesar Rivas Santiago, Jose A Enciso-Moreno, Bruno Rivas-Santiago
Elderly individuals are susceptible to develop infectious diseases; promoting innate immunity to prevent infections is a key issue. Human β-defensin-2 (hBD-2) is an antimicrobial peptide with antimicrobial and immunomodulatory properties. L-isoleucine and vitamin D are important molecules that induce hBD-2. The Aim of this study was to determine the use L-isoleucine and Vitamin D to induce hBD-2 in cells from healthy elderly individuals and elderly individuals with recurrent infections. We explored three groups: young adults (n = 20) used as control group, elderly adults (n = 18) and elderly with recurrent infections (n = 11)...
October 20, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/29052001/quail-coturnix-japonica-egg-yolk-bioactive-components-attenuate-streptozotocin-induced-testicular-damage-and-oxidative-stress-in-diabetic-rats
#2
Gideon Oludare Oladipo, Chidinma Martha Nlekerem, Emmanuel Oluwafemi Ibukun, Ayodele Oluseyi Kolawole
INTRODUCTION: The testicular milieu is the machinery for the metabolism of testosterone in the male reproductive system. PURPOSE: The dysfunction of this highly regenerating system is inevitable in the condition of glucose imbalance as a result of insulin machinery impairment. Therefore, it is imperative to recommend dietary intervention for attenuating the testicular dysfunction and oxidative stress resulting from STZ-induction of diabetes. METHODS: STZ-induced diabetes (65 mg/kg, ip) was treated with QEYEM (50, 100 and 200 mg/kg/day) and quercetin (50 mg/kg/day) for 7weeks...
October 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29051042/bone-disease-in-primary-hyperparathyroidism
#3
Polyzois Makras, Athanasios D Anastasilakis
Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted in milder forms of bone involvement. New methods of imaging and validation such as high resolution peripheral quantitative computed tomography and trabecular bone score provide evidence of disturbed bone microarchitecture and explain further the increased risk of fractures at both cortical and trabecular skeletal sites...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29050970/polyphenolic-profile-and-biological-activities-of-black-carrot-crude-extract-daucus-carota-l-ssp-sativus-var-atrorubens-alef
#4
A Smeriglio, M Denaro, D Barreca, V D'Angelo, M P Germanò, D Trombetta
Black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) is a valuable source of carbohydrates, minerals and vitamins and contains also high amounts of anthocyanins giving the characteristic deep-purple color. These latter compounds are known as natural dyes used in the food and pharmaceutical industry that have recently attracted much attention for their healthful properties. The aim of this work was to investigate for the first time the polyphenolic profile and biological properties of a black carrot crude extract (BCCE) through an in-depth analysis of the main polyphenolic classes evaluating its antioxidant, cytoprotective and anti-angiogenic properties...
October 16, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29050900/bone-and-mineral-disorders-in-chronic-kidney-disease-implications-for-cardiovascular-health-and-ageing-in-the-general-population
#5
REVIEW
Adrian Covic, Marc Vervloet, Ziad A Massy, Pablo Ureña Torres, David Goldsmith, Vincent Brandenburg, Sandro Mazzaferro, Pieter Evenepoel, Jordi Bover, Mugurel Apetrii, Mario Cozzolino
The patient with chronic kidney disease (CKD) represents an extreme model for arteriosclerosis, vascular calcification, and bone disorders, all of which are also associated with ageing in the general population. These pathological features are also relevant to other common chronic health disorders such as diabetes, and chronic inflammatory and cardiovascular diseases. Although management and interventions for these major risk factors are now incorporated into most public health guidelines (eg, smoking cessation and control of bodyweight and blood pressure, as well as glucose and cholesterol concentrations), some residual cardiovascular risk is not reduced by implementation of these interventions...
October 16, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29050711/prevalence-of-vitamin-d-deficiency-in-pediatric-patients-with-scoliosis-preparing-for-spinal-surgery
#6
Theresa Mayes, Jennifer M Anadio, Peter F Sturm
BACKGROUND: Establishing prevalence of vitamin D deficiency in elective scoliosis surgery may impact clinical outcomes. The objectives of this study were to document vitamin D status of patients with scoliosis preparing for surgical intervention in order to establish frequency of deficiency and determine characteristics influencing levels. METHODS: Records were queried for patients with scoliosis diagnosis who underwent posterior spinal fusion or initial growing rod placement and had serum vitamin 25 hydroxyvitamin D (D25) recorded in the preoperative period...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29050663/vitamin-d-deficiency-induces-eosinophil-spontaneous-activation
#7
Huiying Lu, Rui-Di Xie, Ritian Lin, Cuicui Zhang, Xiao-Jun Xiao, Lin-Jing Li, Zhi-Qiang Liu, Li-Tao Yang, Bai-Sui Feng, Zhan-Ju Liu, Ping-Chang Yang
Eosinophils (Eo) play a critical role in immunity and immune inflammation. The maintenance of Eo homeostasis is not fully understood yet. Vitamin D (VitD) is involved in the regulation of a large number of biochemical reactions. This study tests a hypothesis that VitD receptor (VDR) contributes to the homeostasis of Eos. In this study, EoL-1 cells (an Eo cell line) were cultured in the presence or absence of calcitriol. The Eo-mediators, including major basic protein (MBP), Eo peroxidase (EPX), Eo cationic protein (ECP) and Eo-derived neurotoxin (EDN), were assessed in the culture supernatant and in EoL-1 cells...
October 12, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29050423/effect-of-sodium-selenite-and-selenium-yeast-on-performance-egg-quality-antioxidant-capacity-and-selenium-deposition-of-laying-hens
#8
X J Han, P Qin, W X Li, Q G Ma, C Ji, J Y Zhang, L H Zhao
This study compared the effects of sodium selenite and selenium yeast and their combination on laying performance, egg quality, antioxidant capacity, and selenium (Se) contents in tissues and eggs. Two-hundred-eighty-eight Jing Hong layers that were similar in laying rate (87.5 ± 0.38%) and body weight (1.70 ± 0.02 kg) were randomly distributed into 4 treatments for 11 wk (from 203 d old to 279 d old) with 9 replicates of 8 hens per replicate. The diets (corn-soybean meal diet) were supplemented with 0 [blank control (BC)], 0...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050286/a-prospective-study-of-serum-metabolites-and-glioma-risk
#9
Jiaqi Huang, Stephanie J Weinstein, Cari M Kitahara, Edward D Karoly, Joshua N Sampson, Demetrius Albanes
Malignant glioma is one of the most lethal adult cancers, yet its etiology remains largely unknown. We conducted a prospective serum metabolomic analysis of glioma based on 64 cases and 64 matched controls selected from Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from collection of baseline fasting serum to diagnosis was nine years (inter-decile range 3-20 years). LC/MS-MS identified 730 known metabolites, and conditional logistic regression models estimated odds ratios for one-standard deviation differences in log-metabolite signals...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050147/-association-of-vitamin-d-receptor-gene-polymorphisms-with-idiopathic-hypoparathyroidism-phenotypes
#10
T T Quan, M Nie, Y P Li, Y Jiang, M Li, W B Xia, X W Meng, X P Xing, O Wang
Objective: To explore the association of vitamin D receptor (VDR) gene polymorphisms with idiopathic hypoparathyroidism (IHP). Methods: Two hundred and three patients with IHP and 209 healthy age- and sex-matched subjects were recruited at Peking Union Medical College Hospital between December 1987 and December 2015 as case group and control group, respectively. The VDR gene polymorphisms including rs739837, rs3847987 and rs2228570 were analyzed by Sequenom Mass Array. The frequency of different genotypes and alleles was detected, then their association with pathogenesis of IHP was analyzed...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29048387/vitamin-d-as-a-novel-regulator-of-tumor-metabolism-insights-on-potential-mechanisms-and-implications-for-anti-cancer-therapy
#11
REVIEW
Mohamed A Abu El Maaty, Stefan Wölfl
1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], the bioactive form of vitamin D, has been shown to possess significant anti-tumor potential. While most studies so far have focused on the ability of this molecule to influence the proliferation and apoptosis of cancer cells, more recent data indicate that 1,25(OH)₂D₃ also impacts energy utilization in tumor cells. In this article, we summarize and review the evidence that demonstrates the targeting of metabolic aberrations in cancers by 1,25(OH)₂D₃, and highlight potential mechanisms through which these effects may be executed...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29046816/vitamin-d-binding-protein-is-lower-in-infertile-patients-compared-to-fertile-controls-a-case-control-study
#12
Jason Franasiak, Sue Shapses, Wei Sun, Richard Scott, Xiangbing Wang
BACKGROUND: The importance of vitamin D in general health as well as in human reproductive success has been an area of focus. A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship. METHODS: This case control trial seeks to characterize vitamin D metabolism in infertile patients undergoing natural cycle IVF as compared to normally cycling premenopausal women with proven fertility matched for age and body mass index (BMI)...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/29046405/potato-consumption-does-not-increase-blood-pressure-or-incident-hypertension-in-2-cohorts-of-spanish-adults
#13
Emily A Hu, Miguel A Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Antonio Garcia-Rodriguez, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Cristina Razquin, Mònica Bulló, José V Sorlí, Helmut Schröder, Casey M Rebholz, Estefania Toledo
Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension.Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations.Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means ± SDs) of 42...
October 18, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29046301/bone-mineral-density-during-pregnancy-in-women-participating-in-a-randomized-controlled-trial-of-vitamin-d-supplementation
#14
Wei Wei, Judith R Shary, Elizabeth Garrett-Mayer, Betsy Anderson, Nina E Forestieri, Bruce W Hollis, Carol L Wagner
Background: Little is known about bone mineral density (BMD) during pregnancy. Advances in technology with lower radiation emissions by dual-energy X-ray absorptiometry instruments now permit the safe measurement of BMD during pregnancy.Objective: We evaluated maternal BMD during pregnancy as a function of vitamin D status in women of diverse racial/ethnic backgrounds.Design: A total of 301 women who underwent BMD measurements at 12-20 wk of gestation and again at 0-14 wk postpartum were included in this analysis...
October 18, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29046199/-association-between-serum-25-oh-d-levels-at-birth-and-bronchopulmonary-dysplasia-in-preterm-infants
#15
Ren-Qiang Yu, Dao-Zhen Chen, Qin Zhou, Min Wang, Ying-Zi Mei, Shan-Yu Jiang
OBJECTIVE: To assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were classified into two groups: BPD and control. The association between serum 25(OH)D levels at birth and BPD was analyzed. RESULTS: Serum 25(OH)D levels in the BPD group was significantly lower than those in the control group [(37±17 nmol/L vs 47±20 nmol/L; P<0...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29046037/vitamin-d-and-asthma-in-clinical-practice-the-impact-on-asthma-control
#16
Giorgio Ciprandi, Fabio Gallo
No abstract text is available yet for this article.
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29046026/-influence-of-lifestyle-diet-and-vitamin-d-on-atopy-in-a-population-of-afro-descendant-colombian-children
#17
Luis Carlos Fang-Mercado, Juan Ricardo Urrego-Álvarez, Andrés Ernesto Merlano-Barón, Catherine Meza-Torres, Luz Hernández-Bonfante, Liliana López-Kleine, Javier Marrugo-Cano
BACKGROUND: Allergic conditions have shown an increase in the past few decades. Hygiene, changes in lifestyle, diet and vitamin D have been blamed for this increase. OBJECTIVE: To determine the role of environment, diet and vitamin D in atopic diseases in a population of Colombian Afro-descendant children. METHODS: Cross-sectional, descriptive, observational study in 200 Afro-descendant children of rural and urban areas from northern Colombia...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045466/factors-predicting-cardiovascular-events-in-chronic-kidney-disease-patients-role-of-subclinical-atheromatosis-extent-assessed-by-vascular-ultrasound
#18
José M Valdivielso, Angels Betriu, Montserrat Martinez-Alonso, David Arroyo, Marcelino Bermudez-Lopez, Elvira Fernandez
Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been investigated. In this paper, we examine the prognostic value of subclinical atheromatosis extent, assessed as the number of arterial territories with plaque, in predicting the incidence of major and minor CVE. The NEFRONA is a multicenter, prospective cohorts study that recruited 2445 CKD subjects and 559 controls, free from previous cardiovascular disease, in 81 medical centers across Spain...
2017: PloS One
https://www.readbyqxmd.com/read/29045254/nutritional-interventions-in-sarcopenia-where-do-we-stand
#19
Jean Woo
PURPOSE OF REVIEW: To document recent evidence regarding the role of nutrition as an intervention for sarcopenia. RECENT FINDINGS: A review of seven randomized controlled trials (RCTs) on beta-hydroxy-beta-methylbutyrate (HMB) alone on muscle loss in 147 adults showed greater muscle mass gain in the intervention group, but no benefit in muscle strength and physical performance measures. Three other review articles examined nutrition and exercise as combined intervention, and suggest enhancement of benefits of exercise by nutrition supplements (energy, protein, vitamin D)...
October 17, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29045002/sufficient-vitamin-k-status-combined-with-sufficient-vitamin-d-status-is-associated-with-better-lower-extremity-function-a-prospective-analysis-of-two-knee-osteoarthritis-cohorts
#20
M Kyla Shea, Richard F Loeser, Timothy E McAlindon, Denise K Houston, Stephen B Kritchevsky, Sarah L Booth
OBJECTIVE: Vitamins K and D are important for the function of vitamin K-dependent proteins in joint tissues. It is unclear if these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower-extremity function in the Health, Aging Body Composition Knee OA Sub-study (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI). METHODS: In Health ABC (60% female, 75±3 years) baseline nutrient status was measured using circulating vitamin K and 25(OH)D...
October 17, 2017: Arthritis Care & Research
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