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https://www.readbyqxmd.com/read/29932814/infant-cortisol-stress-response-is-associated-with-thymic-function-and-vaccine-response
#1
M Nazmul Huda, Shaikh M Ahmad, Md Jahangir Alam, Afsana Khanam, Md Nure Alam Afsar, Yukiko Wagatsuma, Rubhana Raqib, Charles B Stephensen, Kevin D Laugero
Stress can impair T cell-mediated immunity. To determine if infants with high stress responses had deficits in T-cell mediated immunity, we examined the association of pain-induced cortisol responsiveness with thymic function and vaccine responses in infants. This study was performed among 306 (male = 153 and female = 153) participants of a randomized, controlled trial examining the effect of neonatal vitamin A supplementation on immune function in Bangladesh (NCT01583972). Salivary cortisol was measured before and 20 min after a needle stick (vaccination) at 6 weeks of age...
June 22, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29932357/lifetime-exposure-to-ultraviolet-radiation-and-the-risk-of-multiple-sclerosis-in-the-us-radiologic-technologists-cohort-study
#2
Lisa G Gallagher, Sindana Ilango, Annette Wundes, Gary A Stobbe, Katherine W Turk, Gary M Franklin, Martha S Linet, D Michal Freedman, Bruce H Alexander, Harvey Checkoway
BACKGROUND: Low exposure to ultraviolet radiation (UVR) from sunlight may be a risk factor for developing multiple sclerosis (MS). Possible pathways may be related to effects on immune system function or vitamin D insufficiency, as UVR plays a role in the production of the active form of vitamin D in the body. OBJECTIVE: This study examined whether lower levels of residential UVR exposure from sunlight were associated with increased MS risk in a cohort of radiologic technologists...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29932341/a-framework-for-measurement-and-harmonization-of-pediatric-multiple-sclerosis-etiologic-research-studies-the-pediatric-ms-tool-kit
#3
Sandra Magalhaes, Brenda Banwell, Amit Bar-Or, Isabel Fortier, Heather E Hanwell, Ming Lim, Georg E Matt, Rinze F Neuteboom, David L O'Riordan, Paul K Schneider, Maura Pugliatti, Bryna Shatenstein, Catherine M Tansey, Evangeline Wassmer, Christina Wolfson
BACKGROUND: While studying the etiology of multiple sclerosis (MS) in children has several methodological advantages over studying etiology in adults, studies are limited by small sample sizes. OBJECTIVE: Using a rigorous methodological process, we developed the Pediatric MS Tool-Kit, a measurement framework that includes a minimal set of core variables to assess etiological risk factors. METHODS: We solicited input from the International Pediatric MS Study Group to select three risk factors: environmental tobacco smoke (ETS) exposure, sun exposure, and vitamin D intake...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29931664/calcium-and-vitamin-d-in-bone-fracture-healing-and-post-traumatic-bone-turnover
#4
V Fischer, M Haffner-Luntzer, M Amling, A Ignatius
Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in calcium and vitamin D are major risk factors for osteoporosis development. Because sufficient amounts of calcium are also required for fracture-callus mineralisation, compromised bone repair that is frequently observed in osteoporotic patients might be attributed to calcium and vitamin D deficiencies. Consequently, calcium and vitamin D supplementation represents a potential strategy for treating compromised fracture healing in osteoporotic patients...
June 22, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29931657/vitamin-d-supplementation-to-persistent-carriers-of-mrsa-a-randomized-and-placebo-controlled-clinical-trial
#5
Linda Björkhem-Bergman, Catharina Missailidis, John Karlsson-Valik, Ann Tammelin, Lena Ekström, Matteo Bottai, Ulf Hammar, Gudrun Lindh, Peter Bergman
Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to all beta-lactam antibiotics and can cause severe infections that are difficult to treat. Eradication strategies with conventional antibiotics are not always effective and alternative approaches are warranted. Here, we tested the hypothesis that daily supplementation with vitamin D for 12 months would reduce MRSA carriage rates among a group of persistent carriers. This was a double-blind, placebo-controlled randomized trial with n = 65 persistent MRSA carriers with 25-hydroxy vitamin D3 (25OHD) < 75 nmol/L, who were followed up with bacterial cultures at baseline and every 3 months for 1 year...
June 21, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29931459/effects-of-vitamin-d3-supplementation-on-muscle-strength-mass-and-physical-performance-in-women-with-vitamin-d-insufficiency-a-randomized-placebo-controlled-trial
#6
Lise Sofie Bislev, Lene Langagergaard Rødbro, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
Vitamin D insufficiency and hyperparathyroidism have been associated with reduced muscle strength, physical performance, postural stability, well-being, and quality of life. In a double-blinded, randomized placebo-controlled trial, we aimed to investigate effects of vitamin D3 supplementation on above-mentioned outcomes in healthy community-dwelling postmenopausal women with plasma levels of 25-hydroxyvitamin D (25(OH)D) below < 50 nmol/l and high parathyroid hormone (PTH) levels. Participants (N = 81) were 1:1 treated with vitamin D3, 70 µg (2800 IU)/day or identical placebo for three months during wintertime (56°N)...
June 21, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29931419/genetic-variants-of-major-genes-contributing-to-phosphate-and-calcium-homeostasis-and-their-association-with-serum-parameters-in-pigs
#7
Franziska Just, Henry Reyer, Eduard Muráni, Siriluck Ponsuksili, Michael Oster, Klaus Wimmers
Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal health. Indeed, bone serves as reservoir for calcium and phosphorus, whose formation and resorption follow specific molecular routes including hormones, receptors, and transcription factors. The objective of the study was to analyze the genetic variation of major components driving mineral utilization such as calcitonin receptor, calcium sensing receptor, fibroblast growth factor 23 (FGF23), parathyroid hormone receptor, osteopontin, stanniocalcin 1, RAF-type zinc finger domain containing 1 (TRAFD1), and vitamin D receptor...
June 22, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29931358/associations-between-change-in-total-and-free-25-hydroxyvitamin-d-with-24-25-dihydroxyvitamin-d-and-parathyroid-hormone
#8
Albert Shieh, Christina Ma, Rene F Chun, Jonas Wittwer-Schegg, Leon Swinkels, Tonnie Huijs, Jeffrey Wang, Ines Donangelo, Martin Hewison, John S Adams
Context: The physiologic role of free 25-hydroxyvitamin D (25(OH)D) in humans is unclear. Objective: To assess whether rise in total versus free 25(OH)D is associated with change in downstream biomarkers of 25(OH)D entry into target cells in kidney (24,25-dihyroxyvitamin D [24,25(OH) 2D ]) and parathyroid (parathyroid hormone [PTH]). Design: 16-week randomized controlled trial. Intervention: 60 mcg (2,400 IU)/day of D3 or 20 mcg/day of 25(OH)D3...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29931068/serum-25-hydroxyvitamin-d-concentrations-are-associated-with-computed-tomography-markers-of-subclinical-interstitial-lung-disease-among-community-dwelling-adults-in-the-multi-ethnic-study-of-atherosclerosis-mesa
#9
Samuel M Kim, Di Zhao, Anna J Podolanczuk, Pamela L Lutsey, Eliseo Guallar, Steven M Kawut, R Graham Barr, Ian H de Boer, Bryan R Kestenbaum, David J Lederer, Erin D Michos
Background: Activated vitamin D has anti-inflammatory properties. 25-Hydroxyvitamin D [25(OH)D] deficiency might contribute to subclinical interstitial lung disease (ILD). Objective: We examined associations between serum 25(OH)D concentrations and subclinical ILD among middle-aged to older adults who were free of cardiovascular disease at baseline. Methods: We studied 6302 Multi-Ethnic Study of Atherosclerosis (MESA) participants who had baseline serum 25(OH)D concentrations and computed tomography (CT) imaging spanning ≤ 10 y...
June 19, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29930537/vitamin-d-3-modulates-impaired-crosstalk-between-rank-and-glucocorticoid-receptor-signaling-in-bone-marrow-cells-after-chronic-prednisolone-administration
#10
Ihor Shymanskyi, Olha Lisakovska, Anna Mazanova, Dmytro Labudzynskyi, Mykola Veliky
The effectiveness of vitamin D3 (cholecalciferol) in counteracting the side effects of glucocorticoid (GC) therapy has been demonstrated previously. Abnormalities in systemic hormonal and local (cytokine) regulation of bone marrow (BM) cells may underlie GC-induced imbalance between osteosynthesis and bone resorption. The cytokine system receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) is considered as an integrating link in the NF-κB-mediated interaction of various cells involved in maintaining osteoblastic-osteoclastic balance, which makes it a pharmacological target for regulation and correction of the bone remodeling process...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29930018/calcium-and-vitamin-d-do-not-prevent-fractures-in-community-dwelling-adults
#11
REVIEW
Ian R Reid
No abstract text is available yet for this article.
June 21, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29929906/outcomes-in-patients-with-renal-hyperparathyroidism-requiring-cinacalcet-pre-operatively-followed-by-parathyroidectomy
#12
Dustin Baker, Shruti Sevak, Rose E Callahan, Peter F Czako, Larry R Lloyd, Sapna Nagar
BACKGROUND: Cinacalcet is an effective treatment for renal hyperthyroidism when traditional medical therapy has failed. We studied the impact of pre-operative cinacalcet administration on post-surgical outcomes. METHODS: A retrospective analysis was performed of patients from 2002 to 2017 diagnosed with renal hyperparathyroidism requiring parathyroidectomy to evaluate the need for post-operative supplementation and outcomes. RESULTS: 102 patients were identified; 34 patients were treated with cinacalcet prior to undergoing parathyroidectomy...
June 19, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29929873/effects-of-vitamin-supplementation-on-inflammatory-markers-and-psychological-wellbeing-among-distressed-women-a-randomized-controlled-trial
#13
J M Oliver-Baxter, H S Whitford, D A Turnbull, M J Bond
BACKGROUND: Multivitamins are a popular supplement taken to promote physical and mental health. During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed. OBJECTIVE: To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivitamins or placebo...
June 7, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29928831/family-history-of-mi-smoking-and-risk-of-periodontal-disease
#14
Y H Yu, L Doucette-Stamm, J Rogus, K Moss, R Y L Zee, B Steffensen, P M Ridker, J E Buring, S Offenbacher, K Kornman, D I Chasman
Periodontal disease (PD) shares common risk factors with cardiovascular disease. Our hypothesis was that having a family history of myocardial infarction (FamHxMI) may be a novel risk factor for PD. Risk assessment based on FamHxMI, conditional on smoking status, was examined given the strong influence of smoking on PD. Exploratory analysis with inflammatory biomarkers and genetic determinants was conducted to understand potential mechanistic links. The Women's Genome Health Study (WGHS) is a prospective cohort of US female health care professionals who provided blood samples at baseline in the Women's Health Study, a 2 × 2 factorial clinical trial investigating vitamin E and aspirin in the prevention of cardiovascular disease and cancer...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29928318/predictors-of-25-hydroxyvitamin-d-status-among-individuals-with-metabolic-syndrome-a-cross-sectional-study
#15
Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Erika Paula Silva Freitas, Ana Paula Trussardi Fayh, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista, Lucia Fátima Campos Pedrosa
Background: The risk of metabolic syndrome can be influenced by inadequate vitamin D levels, and exposure to sunlight is the main external source of vitamin D. The present study assessed the influence of environmental, biological, and nutritional factors in relation to seasonal 25-hydroxyvitamin D (25OHD) concentration in individuals with metabolic syndrome. Methods: This cross-sectional study enrolled 180 individuals with metabolic syndrome aged between 18 and 80 years...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29928126/the-association-between-the-serum-level-of-vitamin-d-and-ischemic-heart-disease-a-study-from-jordan
#16
Mohamad I Jarrah, Nizar M Mhaidat, Karem H Alzoubi, Nasr Alrabadi, Enas Alsatari, Yousef Khader, Moath F Bataineh
Background: Decreased levels of vitamin D were associated with increased risk of multiple diseases, including cardiovascular diseases. However, there seem to be some discrepancies among the results obtained from different studies. The aim of the present study was to explore the importance of having sufficient serum levels of vitamin D in reducing the incidence and the progression of coronary artery stenosis and ischemic heart disease (IHD). Methods: Serum levels of vitamin D were measured using radioimmunoassay in 186 Jordanian patients who underwent investigative coronary catheterization...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29927841/association-between-sex-hormones-and-ambulatory-blood-pressure
#17
Monik C Jiménez, Lu Wang, Julie E Burnig, JoAnn E Manson, John P Forman, Howard D Sesso
INTRODUCTION: Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been associated with increased blood pressure (BP) in women with an inverse association between total testosterone and BP among men. Fewer studies have examined associations with 24-h ambulatory blood pressure (ABP), blunted nocturnal BP decline or the role of dehydroepiandrosterone sulfate (DHEAS), a precursor to androgens. METHODS: Baseline blood samples were assayed for 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL...
June 20, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29926935/bacteria-bones-and-stones-managing-complications-of-short-bowel-syndrome
#18
REVIEW
Erika Johnson, Long Vu, Laura E Matarese
Short bowel syndrome (SBS) occurs in patients who have had extensive resection. The primary physiologic consequence is malabsorption, resulting in fluid and electrolyte abnormalities and malnutrition. Nutrient digestion, absorption, and assimilation may also be diminished by disturbances in the production of bile acids and digestive enzymes. Small bowel dilation, dysmotility, loss of ileocecal valve, and anatomical changes combined with acid suppression and antimotility drugs increase the risk of small intestinal bacterial overgrowth, further contributing to malabsorption...
June 21, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29926136/association-between-vitamin-d-receptor-gene-polymorphisms-and-idiopathic-hypocitraturia-in-a-chinese-bai-population
#19
Kangjian Li, Yuhui Luo, Yin Mo, Jihong Shen, Xiaodong Liu, Hao Li
Idiopathic hypocitraturia (IH) is a risk factor for urolithiasis. IH is associated with vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in a Chinese Han population. However, this association between VDR SNPs and IH has not been recapitulated in a Chinese Bai population. The aim of this study is to investigate the association between VDR SNPs and IH in a Chinese Bai population. A total of 320 participants comprising of 200 Chinese Bai patients with IH and 120 Chinese Bai control participants with normal urinary citrate level were enrolled for this study...
June 20, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29926091/dietary-recommendations-for-adults-with-psoriasis-or-psoriatic-arthritis-from-the-medical-board-of-the-national-psoriasis-foundation-a-systematic-review
#20
Adam R Ford, Michael Siegel, Jerry Bagel, Kelly M Cordoro, Amit Garg, Alice Gottlieb, Lawrence J Green, Johann E Gudjonsson, John Koo, Mark Lebwohl, Wilson Liao, Arthur M Mandelin, Joseph A Markenson, Nehal Mehta, Joseph F Merola, Ronald Prussick, Caitriona Ryan, Sergio Schwartzman, Evan L Siegel, Abby S Van Voorhees, Jashin J Wu, April W Armstrong
Importance: Psoriasis is a chronic, inflammatory skin disease and has significant associated morbidity and effect on quality of life. It is important to determine whether dietary interventions help reduce disease severity in patients with psoriatic diseases. Objective: To make evidence-based dietary recommendations for adults with psoriasis and/or psoriatic arthritis from the Medical Board of the National Psoriasis Foundation. Evidence Review: We used literature from prior systematic reviews as well as additional primary literature from the MEDLINE database from January 1, 2014, to August 31, 2017, that evaluated the impact of diet on psoriasis...
June 20, 2018: JAMA Dermatology
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