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https://www.readbyqxmd.com/read/28202344/testosterone-replacement-therapy-and-components-of-the-metabolic-syndrome
#1
REVIEW
James Anaissie, Natalie H Roberts, Ping Wang, Faysal A Yafi
INTRODUCTION: The prevalence of metabolic syndrome (MetS) is rapidly increasing in the United States and, because of its strong association with male hypogonadism, has become a significant topic of interest in the sexual medicine community. At the center of this conversation is the efficacy and safety of testosterone replacement therapy (TRT) as a therapeutic option for HG and MetS. AIM: To provide a review of the current literature pertaining to TRT and MetS. METHODS: A thorough literature review was performed to review the relation between TRT and MetS using the PubMed online database from 1976 through 2016 with the keywords testosterone, hypogonadism, metabolic syndrome, and testosterone therapy...
February 12, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28201827/hypogonadotropic-hypogonadism-in-non-functioning-pituitary-adenomas-impact-of-intervention
#2
Diana Margarida Monteiro, Paula Freitas, Romana Vieira, Davide Carvalho
To determine the prevalence of hypogonadotropic hypogonadism (HH) among patients with non-functioning pituitary adenomas (NFPA) and the post-surgery outcome on pituitary gonadotropins secretion (PGS); to determine the prevalence of erectile dysfunction (ED) on male patients with NFPA, to evaluate the impact of testosterone replacement therapy (TRT) in those with HH. Retrospective evaluation of gonadal function in 109 NFPA patients (45 males), with a mean age of 51.8 years, diagnosed on the last 10 years. ED questionnaire applied to 34 male patients...
February 15, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28196668/effects-of-sex-hormone-treatment-on-white-matter-microstructure-in-individuals-with-gender-dysphoria
#3
Georg S Kranz, Rene Seiger, Ulrike Kaufmann, Allan Hummer, Andreas Hahn, Sebastian Ganger, Martin Tik, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Sex steroid hormones such as estradiol and testosterone are known to have organizing, as well as activating effects on neural tissue in animals and humans. This study investigated the effects of transgender hormone replacement therapy on white matter microstructure using diffusion tensor imaging. Female-to-male and male-to-female transgender participants were measured at baseline, four weeks and four months past treatment start and compared to female and male controls. We observed androgenization-related reductions in mean diffusivity and increases in fractional anisotropy...
February 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28195993/subcutaneous-testosterone-letrozole-therapy-before-and-concurrent-with-neoadjuvant-breast-chemotherapy-clinical-response-and-therapeutic-implications
#4
Rebecca L Glaser, Anne E York, Constantine Dimitrakakis
OBJECTIVE: Hormone receptor-positive breast cancers respond favorably to subcutaneous testosterone combined with an aromatase inhibitor. However, the effect of testosterone combined with an aromatase inhibitor on tumor response to chemotherapy was unknown. This study investigated the effect of testosterone-letrozole implants on breast cancer tumor response before and during neoadjuvant chemotherapy. METHODS: A 51-year-old woman on testosterone replacement therapy was diagnosed with hormone receptor-positive invasive breast cancer...
February 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28168203/microvesicles-correlated-with-components-of-metabolic-syndrome-in-men-with-type-2-diabetes-mellitus-and-lowered-testosterone-levels-but-were-unaltered-by-testosterone-therapy
#5
Jaco Botha, Line Velling Magnussen, Morten Hjuler Nielsen, Tine Bo Nielsen, Kurt Højlund, Marianne Skovsager Andersen, Aase Handberg
Aims. To investigate how circulating microvesicle phenotypes correlate with insulin sensitivity, body composition, plasma lipids, and hepatic fat accumulation. We hypothesized that changes elicited by testosterone replacement therapy are reflected in levels of microvesicles. Methods. Thirty-nine type 2 diabetic males with lowered testosterone levels were assigned to either testosterone replacement therapy or placebo and evaluated at baseline and after 24 weeks. Microvesicles were analysed by flow cytometry and defined as lactadherin-binding particles within the 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28150363/blood-donation-and-testosterone-replacement-therapy
#6
Benjamin Chin-Yee, Alejandro Lazo-Langner, Terrie Butler-Foster, Cyrus Hsia, Ian Chin-Yee
BACKGROUND: Polycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events. Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). This threshold has been interpreted by some physicians and patients to indicate the need for phlebotomy or blood donation while on TRT. STUDY DESIGN AND METHODS: We reviewed all male blood donors in Southwestern Ontario at Canadian Blood Services from December 2013 to March 2016 who self-identified or were found on donor screening to be on TRT...
February 1, 2017: Transfusion
https://www.readbyqxmd.com/read/28149971/does-your-patient-really-need-testosterone-replacement
#7
REVIEW
J Andrew Hoover, Jeffrey T Kirchner
Or has he been made to think so by direct-to-consumer advertising? Here's how to properly screen patients and when to recommend treatment.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28127501/hippocampal-serotonin-2a-receptor-immunoreactive-neurons-density-increases-after-testosterone-therapy-in-the-gonadectomized-male-mice
#8
Emsehgol Nikmahzar, Mehrdad Jahanshahi, Amir Ghaemi, Gholam Reza Naseri, Ali Reza Moharreri, Ahmad Ali Lotfinia
The change of steroid levels may also exert different modulatory effects on the number and class of serotonin receptors present in the plasma membrane. The effects of chronic treatment of testosterone for anxiety were examined and expression of 5-HT2A serotonergic receptor, neuron, astrocyte, and dark neuron density in the hippocampus of gonadectomized male mice was determined. Thirty-six adult male NMRI mice were randomly divided into six groups: intact-no testosterone treatment (No T), gonadectomy (GDX)-No T, GDX-Vehicle, GDX-6...
December 2016: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28122810/testosterone-prevents-protein-loss-via-the-hepatic-urea-cycle-in-human
#9
Teresa Lam, Anne Poljak, Mark McLean, Neha Bahl, Ken K Y Ho, Vita Birzniece
CONTEXT: The urea cycle is a rate limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE: To determine whether testosterone reduces hepatic urea production. DESIGN: an open label study Patients and Intervention: Eight hypogonadal men were studied at baseline, and after two weeks of transdermal testosterone replacement (Testogel, 100 mg/day)...
January 25, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28118875/testosterone-deficiency-and-sleep-apnea
#10
REVIEW
Omar Burschtin, Jing Wang
Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction...
December 2016: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#11
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28078224/impact-of-recent-fda-ruling-on-testosterone-replacement-therapy-trt
#12
Sarita O Metzger, Arthur L Burnett
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078222/testosterone-replacement-therapy-and-the-heart-friend-foe-or-bystander
#13
REVIEW
David S Lopez, Steven Canfield, Run Wang
The role of testosterone therapy (TTh) in cardiovascular disease (CVD) outcomes is still controversial, and it seems will remain inconclusive for the moment. An extensive body of literature has investigated the association of endogenous testosterone and use of TTh with CVD events including several meta-analyses. In some instances, a number of studies reported beneficial effects of TTh on CVD events and in other instances the body of literature reported detrimental effects or no effects at all. Yet, no review article has scrutinized this body of literature using the magnitude of associations and statistical significance reported from this relationship...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078221/testosterone-replacement-therapy-and-voiding-dysfunction
#14
REVIEW
Wesley Baas, Tobias S Köhler
Testosterone replacement therapy (TRT) represents an increasing popular treatment option for men with late-onset hypogonadism (LOH). Because of unsubstantiated beliefs of testosterone's effect on the prostate, the FDA has recently placed a warning on testosterone products, stating that TRT may worsen benign prostatic hyperplasia (BPH). Within this review article we have demonstrated the current understanding of the physiology of testosterone and its relationship with prostatic and lower urinary tract physiology...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078220/hypogonadism-and-testosterone-replacement-therapy-in-end-stage-renal-disease-esrd-and-transplant-patients
#15
REVIEW
Grace Snyder, Daniel A Shoskes
Hypogonadism is a common problem in the end-stage renal disease (ESRD) and renal transplant population. It has widespread systemic effects and has been linked with mortality in dialysis patients and at the time of renal transplant. The etiology is likely multifactorial and most patients are afflicted by various comorbidities that can contribute to hypogonadism. Clinical manifestations are mostly nonspecific. We review the approach to the diagnosis of hypogonadism, focusing on both laboratory values and clinical signs and symptoms...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078217/testosterone-replacement-in-the-infertile-man
#16
REVIEW
Ahmad Majzoub, Edmund Sabanegh
Hypogonadism is a common clinical condition affecting men of different age groups. In addition to its sexual consequences, it has several implications posing significant concerns for a man's health and well-being. Recent advances in testosterone (T) supplementation have facilitated hypogonadism treatment. Despite that, patients complaining of infertility or seeking conception are still hindered by the unfavorable effects supplemental T has on testicular function. Consequently, alternative approaches that can stimulate endogenous T production are favored...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078216/testosterone-replacement-therapy-role-of-pituitary-and-thyroid-in-diagnosis-and-treatment
#17
REVIEW
Megan Crawford, Laurence Kennedy
Crosstalk among hormones characterizes endocrine function, and assessment of the hypogonadal man should take that into consideration. In men for whom testosterone deficiency is a concern, initial evaluation should include a thorough history and physical exam in which other endocrinopathies are being considered. Hypogonadism can be associated with both pituitary and thyroid dysfunction, for which appropriate biochemical evaluation should be undertaken in certain clinical scenarios. If low serum testosterone is confirmed measurement of luteinizing and follicle stimulating hormones (LH and FSH respectively) is essential to establish whether the hypogonadism is primary or secondary...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078215/off-label-therapies-for-testosterone-replacement
#18
REVIEW
Lorenzo DiGiorgio, Hossein Sadeghi-Nejad
The incidence of hypogonadism has been steadily increasing over the last few years. Exogenous testosterone has been the standard treatment for hypogonadal men, but is associated with suppression of spermatogenesis as well as other possible adverse effects. There are other medications, currently considered "off label" for androgen replenishment, that exert their effect through modulation of the hypothalamic-gonadal axis. These medications increase endogenous testosterone levels and offer a different therapeutic approach...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078214/pharmacology-of-testosterone-replacement-therapy-preparations
#19
REVIEW
Jennifer J Shoskes, Meghan K Wilson, Michael L Spinner
The goal of testosterone replacement therapy (TRT) is to return serum testosterone levels to within physiologic range and improve symptoms in hypogonadal men. Some of the symptoms aimed to improve upon include decreased libido, erectile dysfunction, infertility, hot flashes, depressed mood, and loss of muscle mass or hair. Clinical use of testosterone for replacement therapy began approximately 70 years ago. Over the decades, numerous preparations and formulations have been developed primarily focusing on different routes of delivery and thus pharmacokinetics (PKs)...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078213/adult-onset-hypogonadism-evaluation-and-role-of-testosterone-replacement-therapy
#20
REVIEW
Andrew J Davidiuk, Gregory A Broderick
Testosterone deficiency (TD) has become a growing concern in the field of men's sexual health, with an increasing number of men presenting for evaluation of this condition. Given the increasing demand for testosterone replacement therapy (TRT), a panel of experts met in August of 2015 to discuss the treatment of men who present for evaluation in the setting of low or normal gonadotropin levels and the associated signs and symptoms of hypogonadism. This constellation of factors can be associated with elements of both primary and secondary hypogonadism...
December 2016: Translational Andrology and Urology
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