keyword
MENU ▼
Read by QxMD icon Read
search

Testosterone replacement

keyword
https://www.readbyqxmd.com/read/29777228/effects-of-clomiphene-citrate-on-male-obesity-associated-hypogonadism-a-randomized-double-blind-placebo-controlled-study
#1
Andressa Heimbecher Soares, Nidia Celeste Horie, Lucas Augusto Piccinin Chiang, Bruno Caramelli, Mariana Gomes Matheus, Alexandre Holthausen Campos, Luciana Cavalheiro Marti, Fernanda Agostini Rocha, Marcio C Mancini, Elaine Maria Frade Costa, Cintia Cercato
BACKGROUND: Obesity causes secondary hypogonadism (HG) in men. Standard testosterone (T) replacement therapy improves metabolic parameters but leads to infertility. OBJECTIVE: To evaluate clomiphene citrate (CC) treatment of adult men with male obesity-associated secondary hypogonadism (MOSH). DESIGN: Single-center, randomized, double-blind, placebo-controlled trial. PARTICIPANTS: Seventy-eight men aged 36.5 ± 7...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29774669/obstructive-sleep-apnea-and-testosterone-deficiency
#2
REVIEW
Sung Dong Kim, Kyu Sup Cho
Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA in middle-aged men is often associated with decreased testosterone secretion, together with obesity and aging. Although OSA treatment does not reliably increase testosterone levels in most studies, OSA treatment with testosterone replacement therapy (TRT) may not only improve hypogonadism, but can also alleviate erectile/sexual dysfunction. However, because TRT may exacerbate OSA in some patients, patients should be asked about OSA symptoms before and after starting TRT...
May 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29770127/temporal-expression-patterns-of-genes-related-to-sex-steroid-action-in-sexually-dimorphic-nuclei-during-puberty
#3
Moeko Kanaya, Masahiro Morishita, Shinji Tsukahara
Sex steroids play a major role in sexually dimorphic brain development during not only the perinatal period but also the pubertal period. We previously showed that, in male mice, the estrogen receptor-α ( Esr1 ) and aromatase ( Cyp19a1 ) genes are essential to the sexually dimorphic formation of the anteroventral periventricular nucleus (AVPV) and the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), but the estrogen receptor-β ( Esr2 ) gene is not necessary. We also showed that the androgen receptor ( Ar ) gene is essential to the sexually dimorphic formation of the BNSTp...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29765521/long-term-deficiency-of-vitamin-d-in-germ-cell-testicular-cancer-survivors
#4
Lucia Nappi, Margaret Ottaviano, Pasquale Rescigno, Ladan Fazli, Martin E Gleave, Vincenzo Damiano, Sabino De Placido, Giovannella Palmieri
Background: Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated. Materials and Methods: 25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29750970/bdnf-infusion-into-the-mpn-mag-is-sufficient-to-restore-copulatory-behavior-in-the-castrated-syrian-hamster
#5
Joe C Brague, Christine N Lenchur, Julia M Hayden, Rachel H Davidson, Kelly Corrigan, Garrett T Santini, Jennifer M Swann
Testosterone plays a key role in the expression of male sex behavior by influencing cellular activity and synapses within the magnocellular medial preoptic nucleus (MPN mag), a sub-nucleus of the medial preoptic area (MPOA) in the Syrian hamster. Although the mechanisms underlying hormonally-induced synaptic plasticity in this region remain elusive, the data suggests that an increase in synaptic density may mediate testosterone's effects on copulation. As brain derived neurotrophic factor (BDNF) plays an integral role in regulating synaptic plasticity and gonadal steroids regulate the levels of BDNF, we hypothesize that BDNF may mediate the effects of gonadal hormones on copulatory behavior...
May 8, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29745000/impacts-of-serum-25-oh-vitamin-d-level-on-lower-urinary-tract-symptoms-in-male-a-step-forward-to-decrease-overactive-bladder
#6
Sangjun Yoo, Sohee Oh, Hyung Suk Kim, Han Seok Choi, Juhyun Park, Sung Yong Cho, Hwancheol Son, Hyeon Jeong, Hae Won Lee, Min Chul Cho
OBJECTIVES: To evaluate the impacts of serum vitamin D level on male lower urinary tract symptoms (LUTS). MATERIALS AND METHODS: From 2014 to 2017, 434 male patients with LUTS were included. The impacts of vitamin D on LUTS were evaluated using multivariate analysis to adjust for age, body mass index, prostate specific antigen, testosterone, Hemoglobin A1c, physical activity, and prostate volume. To exclude the effect of seasons, we also analyzed the impacts during each season...
May 9, 2018: BJU International
https://www.readbyqxmd.com/read/29727002/hormone-replacement-therapy-and-opioid-tapering-for-opioid-induced-hypogonadism-among-patients-with-chronic-noncancer-pain-a-systematic-review
#7
Mahmood AminiLari, Priya Manjoo, Samantha Craigie, Rachel Couban, Li Wang, Jason W Busse
Objective: To systematically review evidence addressing the efficacy of testosterone replacement therapy (TRT) and opioid tapering for opioid-induced hypogonadism among patients with chronic noncancer pain. Study Design: Systematic review of randomized controlled trials (RCTs) and observational studies. Methods: We searched MEDLINE, CINAHL, AMED, CENTRAL, CINAHL, DARE, EMBASE, and PsycINFO through August 2017. Eligible studies enrolled ≥10 patients with chronic noncancer pain and opioid-induced hypogonadism and reported the effect of TRT or opioid tapering on a patient-important outcome collected ≥14 days after treatment...
May 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29726651/-testosterone-supplementary-therapy-for-type-2-diabetes-mellitus-males-with-hypogonadism-controversy-and-analysis
#8
REVIEW
Zhen Cheng, Lu-Yao Zhang, Guan-Ming Chen, Wei He, Ke Cai, Zhi-Hong Liao
As more and more studies suggest that type 2 diabetes mellitus (T2DM) is closely related to male hypogonadism, people begin to pay more attention to the role of testosterone in the development of T2DM and the effect and safety of testosterone supplementary therapy. There is some controversy in randomized controlled studies and meta-analyses about the effects of testosterone supplementation on the blood glucose level, androgen deficiency symptoms, and cardiovascular diseases. This review focuses on the diagnosis of hypogonadism in T2DM males, differences in the therapeutic effects and safety of testosterone replacement among different studies, and rational use of testosterone supplementation for T2DM patients...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29725076/the-effects-of-testosterone-replacement-on-penile-structure-and-erectile-function-after-long-term-castration-in-adult-male-rats
#9
Jung Sik Huh, Byung Ha Chung, Chang Hee Hong, Ji Kan Ryu, Jang Hwan Kim, Woong Kyu Han, Kyung Kgi Park
Short periods of testosterone suppression have been shown to reduce trabecular smooth muscle content and increase interstitial connective tissue accumulation in animal models. However, the long-term effects of testosterone suppression remain unclear. The aim of this study was to evaluate the long-term effects of testosterone suppression on penile structure and erectile function in rats. Subjects were divided into two groups by observation period (short-period group (group I), 12 weeks; long-period group (group II), 20 weeks)...
May 4, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29720027/efficacy-of-testosterone-treatment-in-hemodialysis-patients-as-assessed-by-aging-males-symptoms-scores-a-pilot-study
#10
Yasuyuki Inoue, Kenzo Nakamura, Yoshitaka Kuwahara, Yan Lu, Nanako Masuda, Shigeo Horie, Hiroshi Okada, Hisamitsu Ide
Numerous reports point to the beneficial effects of testosterone replacement therapy for patients with late-onset hypogonadism (LOH) syndrome. The aim of this study was to evaluate the effect of intramuscular injection of testosterone enantholactam acid ester on Aging Males' Symptoms (AMS) scores in hemodialysis patients with LOH. A total of 24 male patients with LOH (total AMS scores ≥27) were randomized into groups receiving intramuscular injections of either placebo or testosterone enantholactam acid ester at the dose of 250 mg for 6 months...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29713545/systematic-review-of-hormone-replacement-therapy-in-the-infertile-man
#11
REVIEW
Amr El Meliegy, Ahmad Motawi, Mohamed Ahmed Abd El Salam
Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age. Materials and methods: We performed a comprehensive literature review for the years 1978-2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29708829/the-impact-of-testosterone-replacement-therapy-on-glycemic-control-vascular-function-and-components-of-the-metabolic-syndrome-in-obese-hypogonadal-men-with-type-2-diabetes
#12
Kristina Groti, Ivan Žuran, Blaž Antonič, Lidija Foršnarič, Marija Pfeifer
OBJECTIVE: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2). STUDY DESIGN: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i...
April 30, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29707681/hershberger-assays-for-di-2-ethylhexyl-phthalate-and-its-substitute-candidates
#13
Hee-Su Kim, Yong-Pil Cheon, Sung-Ho Lee
In the present study, we employed Hershberger assay to determine possible androgenic or antiandrogenic activities of three di-2-ethylhexyl phthalate (DEHP) substitute candidates. The assay was carried out using immature castrated Sprague-Dawley male rats. After 7 days of the surgery, testosterone propionate (TP, 0.4 mg/kg/day) and test materials (low dose, 40 mg/kg/day; high dose, 400 mg/kg/day) were administered for 10 consecutive days by subcutaneous (s.c.) injection and oral gavage, respectively. Test materials were DEHP, 2-ethylhexyl oleate (IOO), 2-ethylhexyl stearate (IOS) and triethyl 2-acetylcitrate (ATEC)...
March 2018: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29706034/emerging-evidences-in-the-long-standing-controversy-regarding-testosterone-replacement-therapy-and-cardiovascular-events
#14
REVIEW
Jonathan Clavell-Hernández, Run Wang
The increasing rate of late-onset hypogonadism has led to an exceptional growth in the use of testosterone therapy (TTh). Even though TTh has been used for more than 70 years, there has been an emerging controversy in the past several years regarding its safety due to a suggested increased risk of cardiovascular (CV) disease among its users. Given the growing prevalence of testosterone deficiency in our population and the increased use of TTh, the goal of this review is to present the history and emerging evidence in regards to this controversy...
May 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29703008/effectiveness-of-testosterone-therapy-in-obese-men-with-low-testosterone-levels-for-losing-weight-controlling-obesity-complications-and-preventing-cardiovascular-events-protocol-of-a-systematic-review-of-randomized-controlled-trials
#15
REVIEW
Amanda S Mangolim, Leonardo A R Brito, Vania S Nunes-Nogueira
BACKGROUND: The use of testosterone replacement therapy in obese men with low testosterone levels has been controversial. This review aims to analyze the effectiveness of testosterone therapy for weight loss and preventing cardiovascular complications in obese men with low testosterone levels. METHODS: We will perform a systematic review according to Cochrane Methodology of randomized studies, including crossover studies, wherein patients are allocated into one of the two groups: testosterone therapy and control (no treatment or placebo)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696556/long-term-effect-of-testosterone-replacement-therapy-on-bone-in-hypogonadal-men-with-klinefelter-syndrome
#16
N Tahani, L Nieddu, G Prossomariti, M Spaziani, S Granato, F Carlomagno, A Anzuini, A Lenzi, A F Radicioni, E Romagnoli
PURPOSE: To assess different aspects of bone damage in untreated adult patients with Klinefelter Syndrome (KS) before and during testosterone replacement therapy (TRT). METHODS: Fifteen untreated hypogonadal men with KS and 26 control subjects (C) matched for age and BMI were recruited. Sex hormone levels were measured in all subjects. Lumbar spine (LS) and femoral (neck: FN and total hip: TH) bone mineral density (BMD), trabecular bone score (TBS), hip structure analysis (HSA) and fat measures (percentage of fat mass, android/gynoid ratio and visceral adipose tissue) were evaluated by DEXA...
April 25, 2018: Endocrine
https://www.readbyqxmd.com/read/29683499/the-role-of-androgens-on-periodontal-repair-in-female-rats
#17
João Paulo Steffens, Luis Carlos Leal Santana, Jonleno Coutinho Paiva Pitombo, Daniel Olivio Ribeiro, Maria Carolina Costa Albaricci, Stephanie von Stein Cubas Warnavin, Alpdogan Kantarci, Luis Carlos Spolidorio
BACKGROUND: Testosterone replacement enhances cognitive function and musculoskeletal health in postmenopausal women. However, the biological role of testosterone on inflammation and bone metabolism in females is not well understood. Our objective was to measure the impact of androgens and their receptors on periodontal tissues during periodontal repair in female rats. METHODS: Seventy female Holtzman rats were divided into seven groups (n = 10/group): negative control; repair control; androgen receptor antagonist (flutamide, 50 mg/kg, every other day); estrogen receptor antagonist (fulvestrant, 1...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29683497/long-term-testosterone-depletion-attenuates-inflammatory-bone-resorption-in-the-ligature-induced-periodontal-disease-model
#18
Vinícius de Paiva Gonçalves, Adriana Alicia C Ortega, João Paulo Steffens, Denise Madalena Palomari Spolidorio, Carlos Rossa, Luis C Spolidorio
BACKGROUND: Testosterone is known to affect bone in physiological and pathological conditions. The purpose of this study is to evaluate the role of testosterone in experimental periodontal disease in rats. METHODS: In this study we used a ligature model of periodontal disease in rats submitted to orchiectomy (OCX, testosterone depletion) with and without testosterone replacement therapy (TR). Control animals were sham-operated and retained physiological testosterone levels...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29683475/pharmacological-interventions-for-the-prevention-of-insufficiency-fractures-and-avascular-necrosis-associated-with-pelvic-radiotherapy-in-adults
#19
REVIEW
Qurrat U van den Blink, Kate Garcez, Caroline C Henson, Susan E Davidson, Claire E Higham
BACKGROUND: Pelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0...
April 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29675480/pituitary-dysfunction-from-an-unruptured-ophthalmic-internal-carotid-artery-aneurysm-with-improved-2-year-follow-up-results-a-case-report
#20
Meng Qi, Ming Ye, Meng Li, Peng Zhang
Internal carotid artery (ICA) supraclinoid segment aneurysms extending into the sellar region and leading to pituitary dysfunction are a rare occurrence. To date, long-term follow up of pituitary function 2 years post-treatment has never been reported. Herein, we present a case of pituitary dysfunction due to an unruptured ophthalmic segment internal carotid artery aneurysm and report improved 2-year follow-up results. A 76-year-old male presented with disturbed consciousness due to hyponatremia, which was caused by hypoadrenocorticism resulting from pituitary dysfunction complicated by hypogonadism and hypothyroidism...
2018: Open Medicine (Warsaw, Poland)
keyword
keyword
115794
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"